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TDMS Study 93023-07 Pathology Tables

NTP Experiment-Test: 93023-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01
Route: GAVAGE                                                                                                     Time: 11:18:55

                                                         FINAL #1/MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  142-83-6

       Lock Date:  02/24/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 93023-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01    
Route: GAVAGE                                                                                                     Time: 11:18:55    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 4| 4| 4| 4| 4| 8| 5| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Squamous    |                                                                          |             
                                           |__________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                         3                                                |             
      Hyperplasia, Focal, Lymphoid         |                      2                                                   |             
      Hyperplasia, Lymphoid                |                                           2  1                           |             
      Infiltration Cellular, Mixed Cell    | 1     1  2  2  1  1        2     1  2  2     1  1  1  1  1  1  1     1   |             
      Mixed Cell Focus, Multiple           |                                                                          |             
      Bile Duct, Cyst                      |                      4                                                   |             
      Bile Duct, Hyperplasia, Cystic       |                      2                                                   |             
      Bile Duct, Hyperplasia               |                         3                                                |             
      Hepatocyte, Basophilic Focus         |                                                                          |             
      Hepatocyte, Depletion Glycogen,      |                                                                          |             
          Diffuse                          |                                                                          |             
      Hepatocyte, Necrosis, Focal          |                               4                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                3  2  2  3                                                |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |    2                                                                 2   |             
      Hepatocyte, Periportal,              |                                                                          |             
          Vacuolization Cytoplasmic        |       2                             2  3              2     2            |             
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01    
Route: GAVAGE                                                                                                     Time: 11:18:55    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 4| 4| 4| 4| 4| 8| 5| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |    2        3                 3              2  2              2     2   |             
      Oval Cell, Hyperplasia               |                                                                          |             
      Portal, Infiltration Cellular, Focal,|                                                                          |             
           Lymphocyte                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +     +  +     +        +  +  +        +     +     +           +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Angiectasis                          |          2                                                               |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        |    3     3  3     3        3  3  3        3     3     2           3  3   |             
                                           |__________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Infiltration Cellular, Focal, Mixed  |                                                                          |             
          Cell                             |                   1                                                      |             
      Duct, Cyst                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                         2|             
      Epithelium, Hyperplasia, Squamous    |          2                          1                                   2|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Glands, Degeneration, Cystic, Focal  |                                                 1                        |             
      Muscularis, Mineralization           |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
      Pulmonary Artery, Mineralization     |                                                                          |             
      Pulmonary Vein, Mineralization       |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                               1                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01    
Route: GAVAGE                                                                                                     Time: 11:18:55    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 4| 4| 4| 4| 4| 8| 5| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |             1                             1                              |             
      Cytoplasmic Alteration, Focal        |                                                                2         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  M  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Angiectasis                          |                                  1                    3                  |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                2         |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                      2  2                                                |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          |          1                       1                             1     1  3|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01    
Route: GAVAGE                                                                                                     Time: 11:18:55    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 4| 4| 4| 4| 4| 8| 5| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Cyst                                 |                3           3           2                    3            |             
      Cyst, Multiple                       |                                     3                                    |             
      Hyperplasia, Cystic                  |             2                                                            |             
      Hyperplasia, Tubular                 |          2                                                               |             
      Bilateral, Cyst                      |                                                                         3|             
                                           |__________________________________________________________________________|             
   Oviduct                                 |             +                                                            |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 4                        |             
      Cyst                                 |                                                                          |             
      Edema                                |                                              3                           |             
      Hydrometra                           | 3  4     3  4     3  3           2  3  3  2     2  3  3  2  3     3     3|             
      Endometrium, Hyperplasia, Cystic     |       3  3  3  2  3  2  3  3     3  3  3  3  3  3  3  3  3  2  3     2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                            2                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +     +     +                    +                    +|             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Iliac, Pigmentation                  |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                    3                     |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                   3                                                      |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Lymphoid                |                                           3                              |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             3            |             
      Hematopoietic Cell Proliferation     | 3                          2     2  2           3     2              2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01    
Route: GAVAGE                                                                                                     Time: 11:18:55    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 4| 4| 4| 4| 4| 8| 5| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hemorrhage                           |                                                                         4|             
      Hyperplasia, Histiocytic             |             3                                                            |             
      Hyperplasia, Lymphoid                |                   3  2                 2  3  3              2            |             
      Necrosis, Focal                      |                                                                         4|             
                                           |__________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  I  A  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                2                                                         |             
      Hyperplasia                          |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                  3                                       |             
      Hair Follicle, Atrophy, Focal        |                                                    3                     |             
      Subcutaneous Tissue, Fibrosis, Focal |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +              +     +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
      Inflammation, Chronic                |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                                          |             
      Ventricle, Hydrocephalus             |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01    
Route: GAVAGE                                                                                                     Time: 11:18:55    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 4| 4| 4| 4| 4| 8| 5| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Thrombosis                           |    2                                                                     |             
      Artery, Mineralization               |                                                                          |             
      Vein, Mineralization                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2     1              2        2     2  2  2  2  2            |             
      Mucosa, Glands, Dilatation, Focal    |                                                 2        2               |             
      Nasolacrimal Duct, Inflammation      |                                           2                              |             
      Nasolacrimal Duct, Mineralization    |                                                                          |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |                3     2     3        2  2  2  2  2  1  2  1  2  2     2   |             
      Respiratory Epithelium, Cytoplasmic  |                                                                          |             
          Alteration                       | 1  3  3  3  3  1  3  3  2  3  2  3  2  2  2  2  2  2  2  2  2  3  3  2  3|             
                                           |__________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Hyperplasia, Focal, Squamous |                                                                          |             
      Cornea, Inflammation, Focal          |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                  +        +        +                     |             
      Hyperplasia, Focal                   |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Infarct, Focal                       |                                                                          |             
      Infarct                              |                                                                          |             
      Metaplasia, Focal, Osseous           |       1                                                                  |             
      Nephropathy                          | 1                          3           1        1        1     1         |             
      Artery, Mineralization               |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01    
Route: GAVAGE                                                                                                     Time: 11:18:55    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 3| 9| 3| 3| 3| 4| 4| 4| 4| 4| 8| 5| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
          Droplet                          |                               3                                         3|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________