Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/4384

TDMS Study 93026-06 Pathology Tables

NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02

                                                      Final#1, Revision#2




       Facility:  Battelle Northwest

       Chemical CAS #:  91-17-8

       Lock Date:  01/04/01

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            7            3            6                                     
    Moribund Sacrifice                                10           15           11            8                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Moribund Sacrifice                                                                        1                                     
    Terminal Sacrifice                                37           28           35           35                                     
                                                                                                                                    
  Animals Examined Microscopically                    49           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                                                                       
   Intestine Large, Rectum                            (49)         (47)         (49)         (48)                                   
      Necrosis                                                      1 (2%)                                                          
   Intestine Small, Duodenum                          (48)         (43)         (47)         (47)                                   
      Inflammation, Acute                                                                     1 (2%)                                
      Necrosis                                                                   1 (2%)       1 (2%)                                
   Intestine Small, Jejunum                           (48)         (45)         (48)         (45)                                   
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
   Intestine Small, Ileum                             (47)         (45)         (49)         (47)                                   
      Infiltration Cellular, Mixed Cell                             2 (4%)                                                          
      Inflammation, Granulomatous                                                             1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
   Liver                                              (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                    1 (2%)       1 (2%)                                
      Basophilic Focus                                 8 (16%)      7 (14%)      6 (12%)      3 (6%)                                
      Clear Cell Focus                                 2 (4%)       2 (4%)       4 (8%)       1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Eosinophilic Focus                               8 (16%)      6 (12%)     11 (22%)     11 (22%)                               
      Fatty Change                                     2 (4%)                    2 (4%)       2 (4%)                                
      Hematopoietic Cell Proliferation                              2 (4%)                    3 (6%)                                
      Infarct                                          1 (2%)       2 (4%)                                                          
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Granulomatous                     16 (33%)     11 (22%)     16 (32%)     16 (32%)                               
      Mitotic Alteration                                            1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mixed Cell Focus                                              1 (2%)                                                          
      Necrosis                                                                   1 (2%)       1 (2%)                                
      Tension Lipidosis                                             3 (6%)                    4 (8%)                                
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic                                     1 (2%)                    1 (2%)                                
      Bile Duct, Cyst                                               1 (2%)                                                          
      Centrilobular, Degeneration                      1 (2%)                                                                       
      Centrilobular, Necrosis                                       1 (2%)                    2 (4%)                                
      Oval Cell, Hyperplasia                                                     1 (2%)                                             
   Mesentery                                          (17)         (18)         (12)         (18)                                   
      Inflammation, Granulomatous                      2 (12%)                                2 (11%)                               
      Thrombosis                                                    1 (6%)                                                          
      Fat, Hemorrhage                                               1 (6%)                                                          
      Fat, Necrosis                                   16 (94%)     16 (89%)     11 (92%)     16 (89%)                               
   Pancreas                                           (49)         (47)         (50)         (49)                                   
      Angiectasis                                                                             1 (2%)                                
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Basophilic Focus                                 1 (2%)                    1 (2%)                                             
      Lipomatosis                                      1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Degeneration                                     1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (49)         (50)         (47)                                   
      Hyperplasia, Squamous                            5 (10%)      1 (2%)       6 (12%)      2 (4%)                                
      Inflammation, Acute                              1 (2%)                    1 (2%)       2 (4%)                                
   Stomach, Glandular                                 (48)         (47)         (50)         (47)                                   
      Infiltration Cellular, Mixed Cell                1 (2%)                                                                       
      Mineralization                                                2 (4%)       3 (6%)       1 (2%)                                
      Necrosis                                         1 (2%)                    1 (2%)                                             
   Tooth                                              (4)          (2)          (1)          (1)                                    
      Inflammation, Chronic Active                                  1 (50%)                                                         
      Malformation                                     3 (75%)      1 (50%)      1 (100%)     1 (100%)                              
      Dentine, Incisor, Dysplasia                      1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (2)                                                 
      Aorta, Mineralization                                                      1 (50%)                                            
   Heart                                              (49)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   8 (16%)     10 (20%)     13 (26%)      8 (16%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                                             1 (2%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Atrium, Inflammation, Acute                                   1 (2%)                                                          
      Atrium, Thrombosis                                                                      1 (2%)                                
      Capillary, Hyperplasia                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (49)                                   
      Hyperplasia                                      6 (12%)      7 (14%)      5 (10%)      5 (10%)                               
      Hypertrophy                                      3 (6%)       8 (16%)      2 (4%)       6 (12%)                               
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
      Subcapsular, Hyperplasia                         1 (2%)       1 (2%)                                                          
   Adrenal Medulla                                    (48)         (50)         (50)         (49)                                   
      Hyperplasia                                      1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
   Islets, Pancreatic                                 (49)         (47)         (50)         (49)                                   
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (49)         (49)         (49)         (50)                                   
      Pars Distalis, Angiectasis                       1 (2%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia                      20 (41%)     20 (41%)     20 (41%)     12 (24%)                               
      Pars Intermedia, Hyperplasia                     2 (4%)                                                                       
      Pars Intermedia, Hypertrophy                                               1 (2%)       1 (2%)                                
   Thyroid Gland                                      (49)         (49)         (50)         (47)                                   
      Cyst                                             1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (49)         (49)         (48)                                   
      Angiectasis                                                   2 (4%)       1 (2%)       1 (2%)                                
      Cyst                                            16 (33%)     11 (22%)      8 (16%)     10 (21%)                               
      Hyperplasia, Tubular                             1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
   Uterus                                             (49)         (49)         (50)         (49)                                   
      Angiectasis                                      1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hyperplasia, Cystic                              3 (6%)       3 (6%)       5 (10%)                                            
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
      Endometrium, Hyperplasia, Cystic                 7 (14%)      5 (10%)      4 (8%)       8 (16%)                               
      Lymphatic, Cyst                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (5)          (2)          (4)          (1)                                    
      Lumbar, Angiectasis                                                        1 (25%)                                            
      Renal, Angiectasis                               2 (40%)                                                                      
   Lymph Node, Bronchial                              (41)         (45)         (47)         (44)                                   
      Infiltration Cellular, Plasma Cell                            1 (2%)       1 (2%)                                             
   Lymph Node, Mandibular                             (36)         (40)         (37)         (41)                                   
      Hyperplasia, Lymphoid                                         1 (3%)                                                          
      Infiltration Cellular, Mast Cell                 1 (3%)                                                                       
   Lymph Node, Mesenteric                             (47)         (47)         (50)         (47)                                   
      Angiectasis                                                   1 (2%)       2 (4%)       2 (4%)                                
      Ectasia                                                       1 (2%)                                                          
      Infiltration Cellular, Plasma Cell               1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                                   1 (2%)                    1 (2%)                                
   Lymph Node, Mediastinal                            (43)         (42)         (43)         (46)                                   
      Congestion                                                                              1 (2%)                                
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
   Spleen                                             (49)         (47)         (50)         (48)                                   
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)                    1 (2%)                                
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
   Thymus                                             (48)         (48)         (48)         (47)                                   
      Necrosis                                                      1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       1 (2%)       1 (2%)                                             
   Skin                                               (49)         (50)         (50)         (50)                                   
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
      Infiltration Cellular, Mixed Cell                1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Granulomatous                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           3 (6%)       3 (6%)       2 (4%)       2 (4%)                                
   Skeletal Muscle                                                 (2)                                                              
      Necrosis, Fatty                                               1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                                                   1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (50)         (50)         (49)                                   
      Inflammation, Acute                                                        1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
   Lung                                               (49)         (50)         (50)         (50)                                   
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                                                3 (6%)                                             
      Mineralization                                                             1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 4 (8%)       2 (4%)       3 (6%)       4 (8%)                                
      Alveolus, Infiltration Cellular, Histiocyte      3 (6%)                    1 (2%)       3 (6%)                                
      Artery, Inflammation, Chronic                                                           1 (2%)                                
      Bronchiole, Hyperplasia                                       1 (2%)                    1 (2%)                                
   Nose                                               (49)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                        3 (6%)       1 (2%)                    1 (2%)                                
      Glands, Dilatation                                                         1 (2%)       5 (10%)                               
      Olfactory Epithelium, Atrophy                                              1 (2%)       2 (4%)                                
      Respiratory Epithelium, Metaplasia, Squamous                                            1 (2%)                                
      Sinus, Foreign Body                                           1 (2%)                    1 (2%)                                
   Trachea                                            (49)         (49)         (50)         (49)                                   
      Inflammation, Acute                                                        1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)                                                 
      Cornea, Inflammation, Chronic Active             1 (50%)      1 (100%)     1 (50%)                                            
   Harderian Gland                                    (4)          (4)          (5)          (3)                                    
      Hyperplasia                                                                             1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Amyloid Deposition                                            1 (2%)                    1 (2%)                                
      Infarct                                          4 (8%)       2 (4%)                                                          
      Metaplasia, Osseous                              4 (8%)       1 (2%)       1 (2%)       3 (6%)                                
      Nephropathy                                     45 (92%)     40 (80%)     40 (80%)     41 (82%)                               
      Pelvis, Dilatation                               1 (2%)                                                                       
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
      Renal Tubule, Necrosis                                                                  1 (2%)                                
      Renal Tubule, Vacuolization Cytoplasmic                                    1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            7            7            5                                     
    Natural Death                                      3            2            7           11                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           41           35           33                                     
    Moribund Sacrifice                                                                        1                                     
    Natural Death                                      1                         1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (40)         (41)         (40)                                   
      Degeneration, Hyaline                            1 (2%)                                 3 (8%)                                
      Hyperplasia                                                   1 (3%)                    1 (3%)                                
   Intestine Large, Colon                             (49)         (48)         (49)         (49)                                   
      Hemorrhage                                                                              1 (2%)                                
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
      Serosa, Inflammation, Chronic                                              1 (2%)                                             
   Intestine Large, Cecum                             (48)         (48)         (49)         (46)                                   
      Hemorrhage                                                                              1 (2%)                                
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Serosa, Inflammation, Granulomatous              1 (2%)                                                                       
   Intestine Small, Duodenum                          (47)         (48)         (47)         (43)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Intestine Small, Jejunum                           (46)         (48)         (47)         (43)                                   
      Infiltration Cellular, Mixed Cell                1 (2%)                                 1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
   Intestine Small, Ileum                             (46)         (48)         (47)         (46)                                   
      Hyperplasia                                                                             1 (2%)                                
      Infiltration Cellular, Mixed Cell                             1 (2%)                    1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Basophilic Focus                                 9 (18%)      6 (12%)     13 (26%)     13 (26%)                               
      Clear Cell Focus                                17 (34%)     21 (42%)     16 (32%)     21 (42%)                               
      Eosinophilic Focus                              10 (20%)      9 (18%)      7 (14%)     19 (38%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Erythrophagocytosis                                                                     9 (18%)                               
      Fatty Change                                     1 (2%)                    3 (6%)       3 (6%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Infarct                                                       1 (2%)                                                          
      Inflammation, Granulomatous                      5 (10%)      6 (12%)      9 (18%)      3 (6%)                                
      Mixed Cell Focus                                                                        1 (2%)                                
      Necrosis                                                      1 (2%)       3 (6%)      19 (38%)                               
      Syncytial Alteration                            26 (52%)     28 (56%)     36 (72%)     44 (88%)                               
      Tension Lipidosis                                2 (4%)       5 (10%)                   1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
      Bile Duct, Degeneration, Hyaline                                                        1 (2%)                                
      Centrilobular, Hypertrophy                       2 (4%)                    4 (8%)      36 (72%)                               
      Centrilobular, Necrosis                                                    4 (8%)       2 (4%)                                
   Mesentery                                          (14)         (11)         (10)         (15)                                   
      Inflammation, Granulomatous                      3 (21%)      1 (9%)       2 (20%)      3 (20%)                               
      Artery, Inflammation, Chronic Active                          1 (9%)                                                          
      Fat, Necrosis                                   12 (86%)      9 (82%)      9 (90%)     12 (80%)                               
   Pancreas                                           (49)         (50)         (50)         (49)                                   
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Basophilic Focus                                              1 (2%)       1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Lipomatosis                                      1 (2%)       1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)         (49)         (50)                                   
      Hyperplasia, Squamous                            4 (8%)       4 (8%)       1 (2%)       9 (18%)                               
      Inflammation, Acute                              2 (4%)       1 (2%)       1 (2%)       4 (8%)                                
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Necrosis                                         1 (2%)       1 (2%)                    4 (8%)                                
   Stomach, Glandular                                 (49)         (49)         (48)         (48)                                   
      Hyperplasia                                                   1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Necrosis                                                                   2 (4%)                                             
   Tooth                                              (23)         (26)         (22)         (21)                                   
      Inflammation, Chronic Active                     1 (4%)                                                                       
      Malformation                                    21 (91%)     26 (100%)    22 (100%)    20 (95%)                               
      Dentine, Incisor, Dysplasia                      1 (4%)                                 1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (3)                       (1)                                    
      Inflammation, Chronic Active                     1 (100%)     1 (33%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Cardiomyopathy                                   9 (18%)      8 (16%)      7 (14%)      7 (14%)                               
      Mineralization                                                             1 (2%)       1 (2%)                                
      Artery, Inflammation, Chronic Active             1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Hyperplasia                                     23 (47%)     16 (32%)     13 (26%)     14 (28%)                               
      Hypertrophy                                     37 (76%)     42 (84%)     30 (60%)     26 (52%)                               
      Subcapsular, Hyperplasia                                                                1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      3 (6%)                                 3 (6%)                                
   Islets, Pancreatic                                 (49)         (50)         (50)         (49)                                   
      Hypertrophy                                                   2 (4%)                                                          
   Pituitary Gland                                    (48)         (50)         (50)         (49)                                   
      Cyst                                                          1 (2%)                    1 (2%)                                
      Pars Distalis, Hyperplasia                       2 (4%)       1 (2%)       3 (6%)       3 (6%)                                
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
      Pars Intermedia, Hypertrophy                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 (2%)       2 (4%)       1 (2%)       3 (6%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
   Preputial Gland                                    (49)         (49)         (50)         (50)                                   
      Ectasia                                         28 (57%)     24 (49%)     21 (42%)     22 (44%)                               
      Hyperplasia, Squamous                                                                   1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
   Prostate                                           (48)         (50)         (50)         (50)                                   
      Hyperplasia                                                   2 (4%)                                                          
      Inflammation, Chronic Active                                               2 (4%)                                             
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Seminal Vesicle                                    (49)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                                         1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Interstitial Cell, Hyperplasia                   2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (48)                                   
      Angiectasis                                                                             1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
   Lymph Node                                         (1)                       (3)          (1)                                    
      Iliac, Infiltration Cellular, Plasma Cell                                  1 (33%)      1 (100%)                              
   Lymph Node, Mesenteric                             (49)         (48)         (50)         (47)                                   
      Angiectasis                                      2 (4%)                                                                       
      Infiltration Cellular, Plasma Cell                            2 (4%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Mixed Cell                2 (4%)                                 1 (2%)                                
   Lymph Node, Mediastinal                            (41)         (36)         (42)         (35)                                   
      Inflammation, Granulomatous                      1 (2%)                                                                       
   Spleen                                             (49)         (50)         (50)         (49)                                   
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
   Thymus                                             (44)         (44)         (42)         (40)                                   
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Inflammation, Acute                                                        1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       2 (4%)       4 (8%)                                
      Lymphatic, Angiectasis                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Degeneration, Hyaline                                                                   1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                      3 (6%)                    2 (4%)       1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 5 (10%)      2 (4%)       2 (4%)       6 (12%)                               
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)       2 (4%)                                                          
   Nose                                               (50)         (50)         (50)         (48)                                   
      Inflammation, Suppurative                        1 (2%)       2 (4%)       4 (8%)       2 (4%)                                
      Polyp, Inflammatory                                           1 (2%)                                                          
      Thrombosis                                                    2 (4%)                                                          
      Glands, Dilatation                               2 (4%)       2 (4%)       1 (2%)       3 (6%)                                
      Olfactory Epithelium, Atrophy                    1 (2%)       1 (2%)       3 (6%)                                             
      Sinus, Foreign Body                              1 (2%)                                                                       
   Trachea                                            (49)         (50)         (49)         (48)                                   
      Degeneration, Hyaline                                                                   1 (2%)                                
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (3)          (2)          (1)                                    
      Cataract                                         2 (67%)                                                                      
      Degeneration                                                  1 (33%)                                                         
      Cornea, Inflammation, Chronic Active                          1 (33%)                                                         
   Harderian Gland                                    (9)          (5)          (5)          (5)                                    
      Hyperplasia                                      1 (11%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (49)                                   
      Cyst                                                          1 (2%)                                                          
      Infarct                                          3 (6%)       2 (4%)       5 (10%)      1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Metaplasia, Osseous                              3 (6%)       3 (6%)       5 (10%)      2 (4%)                                
      Mineralization                                                             1 (2%)                                             
      Nephropathy                                     47 (96%)     46 (92%)     47 (94%)     41 (84%)                               
      Renal Tubule, Hyperplasia                        1 (2%)                                 2 (4%)                                
      Renal Tubule, Karyomegaly                                     1 (2%)       1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------