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TDMS Study 93026-06 Pathology Tables

NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02

                                                      Final#1, Revision#2




       Facility:  Battelle Northwest

       Chemical CAS #:  91-17-8

       Lock Date:  01/04/01

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            7            3            6                                     
    Moribund Sacrifice                                10           15           11            8                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Moribund Sacrifice                                                                        1                                     
    Terminal Sacrifice                                37           28           35           35                                     
                                                                                                                                    
  Animals Examined Microscopically                    49           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                                                                       
   Intestine Large, Rectum                            (49)         (47)         (49)         (48)                                   
      Necrosis                                                      1 (2%)                                                          
   Intestine Small, Duodenum                          (48)         (43)         (47)         (47)                                   
      Inflammation, Acute                                                                     1 (2%)                                
      Necrosis                                                                   1 (2%)       1 (2%)                                
   Intestine Small, Jejunum                           (48)         (45)         (48)         (45)                                   
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
   Intestine Small, Ileum                             (47)         (45)         (49)         (47)                                   
      Infiltration Cellular, Mixed Cell                             2 (4%)                                                          
      Inflammation, Granulomatous                                                             1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
   Liver                                              (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                    1 (2%)       1 (2%)                                
      Basophilic Focus                                 8 (16%)      7 (14%)      6 (12%)      3 (6%)                                
      Clear Cell Focus                                 2 (4%)       2 (4%)       4 (8%)       1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Eosinophilic Focus                               8 (16%)      6 (12%)     11 (22%)     11 (22%)                               
      Fatty Change                                     2 (4%)                    2 (4%)       2 (4%)                                
      Hematopoietic Cell Proliferation                              2 (4%)                    3 (6%)                                
      Infarct                                          1 (2%)       2 (4%)                                                          
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Granulomatous                     16 (33%)     11 (22%)     16 (32%)     16 (32%)                               
      Mitotic Alteration                                            1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mixed Cell Focus                                              1 (2%)                                                          
      Necrosis                                                                   1 (2%)       1 (2%)                                
      Tension Lipidosis                                             3 (6%)                    4 (8%)                                
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic                                     1 (2%)                    1 (2%)                                
      Bile Duct, Cyst                                               1 (2%)                                                          
      Centrilobular, Degeneration                      1 (2%)                                                                       
      Centrilobular, Necrosis                                       1 (2%)                    2 (4%)                                
      Oval Cell, Hyperplasia                                                     1 (2%)                                             
   Mesentery                                          (17)         (18)         (12)         (18)                                   
      Inflammation, Granulomatous                      2 (12%)                                2 (11%)                               
      Thrombosis                                                    1 (6%)                                                          
      Fat, Hemorrhage                                               1 (6%)                                                          
      Fat, Necrosis                                   16 (94%)     16 (89%)     11 (92%)     16 (89%)                               
   Pancreas                                           (49)         (47)         (50)         (49)                                   
      Angiectasis                                                                             1 (2%)                                
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Basophilic Focus                                 1 (2%)                    1 (2%)                                             
      Lipomatosis                                      1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Degeneration                                     1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (49)         (50)         (47)                                   
      Hyperplasia, Squamous                            5 (10%)      1 (2%)       6 (12%)      2 (4%)                                
      Inflammation, Acute                              1 (2%)                    1 (2%)       2 (4%)                                
   Stomach, Glandular                                 (48)         (47)         (50)         (47)                                   
      Infiltration Cellular, Mixed Cell                1 (2%)                                                                       
      Mineralization                                                2 (4%)       3 (6%)       1 (2%)                                
      Necrosis                                         1 (2%)                    1 (2%)                                             
   Tooth                                              (4)          (2)          (1)          (1)                                    
      Inflammation, Chronic Active                                  1 (50%)                                                         
      Malformation                                     3 (75%)      1 (50%)      1 (100%)     1 (100%)                              
      Dentine, Incisor, Dysplasia                      1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (2)                                                 
      Aorta, Mineralization                                                      1 (50%)                                            
   Heart                                              (49)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   8 (16%)     10 (20%)     13 (26%)      8 (16%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                                             1 (2%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Atrium, Inflammation, Acute                                   1 (2%)                                                          
      Atrium, Thrombosis                                                                      1 (2%)                                
      Capillary, Hyperplasia                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (49)                                   
      Hyperplasia                                      6 (12%)      7 (14%)      5 (10%)      5 (10%)                               
      Hypertrophy                                      3 (6%)       8 (16%)      2 (4%)       6 (12%)                               
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
      Subcapsular, Hyperplasia                         1 (2%)       1 (2%)                                                          
   Adrenal Medulla                                    (48)         (50)         (50)         (49)                                   
      Hyperplasia                                      1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
   Islets, Pancreatic                                 (49)         (47)         (50)         (49)                                   
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (49)         (49)         (49)         (50)                                   
      Pars Distalis, Angiectasis                       1 (2%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia                      20 (41%)     20 (41%)     20 (41%)     12 (24%)                               
      Pars Intermedia, Hyperplasia                     2 (4%)                                                                       
      Pars Intermedia, Hypertrophy                                               1 (2%)       1 (2%)                                
   Thyroid Gland                                      (49)         (49)         (50)         (47)                                   
      Cyst                                             1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (49)         (49)         (48)                                   
      Angiectasis                                                   2 (4%)       1 (2%)       1 (2%)                                
      Cyst                                            16 (33%)     11 (22%)      8 (16%)     10 (21%)                               
      Hyperplasia, Tubular                             1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
   Uterus                                             (49)         (49)         (50)         (49)                                   
      Angiectasis                                      1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hyperplasia, Cystic                              3 (6%)       3 (6%)       5 (10%)                                            
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
      Endometrium, Hyperplasia, Cystic                 7 (14%)      5 (10%)      4 (8%)       8 (16%)                               
      Lymphatic, Cyst                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (5)          (2)          (4)          (1)                                    
      Lumbar, Angiectasis                                                        1 (25%)                                            
      Renal, Angiectasis                               2 (40%)                                                                      
   Lymph Node, Bronchial                              (41)         (45)         (47)         (44)                                   
      Infiltration Cellular, Plasma Cell                            1 (2%)       1 (2%)                                             
   Lymph Node, Mandibular                             (36)         (40)         (37)         (41)                                   
      Hyperplasia, Lymphoid                                         1 (3%)                                                          
      Infiltration Cellular, Mast Cell                 1 (3%)                                                                       
   Lymph Node, Mesenteric                             (47)         (47)         (50)         (47)                                   
      Angiectasis                                                   1 (2%)       2 (4%)       2 (4%)                                
      Ectasia                                                       1 (2%)                                                          
      Infiltration Cellular, Plasma Cell               1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                                   1 (2%)                    1 (2%)                                
   Lymph Node, Mediastinal                            (43)         (42)         (43)         (46)                                   
      Congestion                                                                              1 (2%)                                
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
   Spleen                                             (49)         (47)         (50)         (48)                                   
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)                    1 (2%)                                
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
   Thymus                                             (48)         (48)         (48)         (47)                                   
      Necrosis                                                      1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       1 (2%)       1 (2%)                                             
   Skin                                               (49)         (50)         (50)         (50)                                   
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
      Infiltration Cellular, Mixed Cell                1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Granulomatous                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           3 (6%)       3 (6%)       2 (4%)       2 (4%)                                
   Skeletal Muscle                                                 (2)                                                              
      Necrosis, Fatty                                               1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                                                   1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (50)         (50)         (49)                                   
      Inflammation, Acute                                                        1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
   Lung                                               (49)         (50)         (50)         (50)                                   
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                                                3 (6%)                                             
      Mineralization                                                             1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 4 (8%)       2 (4%)       3 (6%)       4 (8%)                                
      Alveolus, Infiltration Cellular, Histiocyte      3 (6%)                    1 (2%)       3 (6%)                                
      Artery, Inflammation, Chronic                                                           1 (2%)                                
      Bronchiole, Hyperplasia                                       1 (2%)                    1 (2%)                                
   Nose                                               (49)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                        3 (6%)       1 (2%)                    1 (2%)                                
      Glands, Dilatation                                                         1 (2%)       5 (10%)                               
      Olfactory Epithelium, Atrophy                                              1 (2%)       2 (4%)                                
      Respiratory Epithelium, Metaplasia, Squamous                                            1 (2%)                                
      Sinus, Foreign Body                                           1 (2%)                    1 (2%)                                
   Trachea                                            (49)         (49)         (50)         (49)                                   
      Inflammation, Acute                                                        1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)                                                 
      Cornea, Inflammation, Chronic Active             1 (50%)      1 (100%)     1 (50%)                                            
   Harderian Gland                                    (4)          (4)          (5)          (3)                                    
      Hyperplasia                                                                             1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Amyloid Deposition                                            1 (2%)                    1 (2%)                                
      Infarct                                          4 (8%)       2 (4%)                                                          
      Metaplasia, Osseous                              4 (8%)       1 (2%)       1 (2%)       3 (6%)                                
      Nephropathy                                     45 (92%)     40 (80%)     40 (80%)     41 (82%)                               
      Pelvis, Dilatation                               1 (2%)                                                                       
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
      Renal Tubule, Necrosis                                                                  1 (2%)                                
      Renal Tubule, Vacuolization Cytoplasmic                                    1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            7            7            5                                     
    Natural Death                                      3            2            7           11                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           41           35           33                                     
    Moribund Sacrifice                                                                        1                                     
    Natural Death                                      1                         1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (40)         (41)         (40)                                   
      Degeneration, Hyaline                            1 (2%)                                 3 (8%)                                
      Hyperplasia                                                   1 (3%)                    1 (3%)                                
   Intestine Large, Colon                             (49)         (48)         (49)         (49)                                   
      Hemorrhage                                                                              1 (2%)                                
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
      Serosa, Inflammation, Chronic                                              1 (2%)                                             
   Intestine Large, Cecum                             (48)         (48)         (49)         (46)                                   
      Hemorrhage                                                                              1 (2%)                                
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Serosa, Inflammation, Granulomatous              1 (2%)                                                                       
   Intestine Small, Duodenum                          (47)         (48)         (47)         (43)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Intestine Small, Jejunum                           (46)         (48)         (47)         (43)                                   
      Infiltration Cellular, Mixed Cell                1 (2%)                                 1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
   Intestine Small, Ileum                             (46)         (48)         (47)         (46)                                   
      Hyperplasia                                                                             1 (2%)                                
      Infiltration Cellular, Mixed Cell                             1 (2%)                    1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Basophilic Focus                                 9 (18%)      6 (12%)     13 (26%)     13 (26%)                               
      Clear Cell Focus                                17 (34%)     21 (42%)     16 (32%)     21 (42%)                               
      Eosinophilic Focus                              10 (20%)      9 (18%)      7 (14%)     19 (38%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Erythrophagocytosis                                                                     9 (18%)                               
      Fatty Change                                     1 (2%)                    3 (6%)       3 (6%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Infarct                                                       1 (2%)                                                          
      Inflammation, Granulomatous                      5 (10%)      6 (12%)      9 (18%)      3 (6%)                                
      Mixed Cell Focus                                                                        1 (2%)                                
      Necrosis                                                      1 (2%)       3 (6%)      19 (38%)                               
      Syncytial Alteration                            26 (52%)     28 (56%)     36 (72%)     44 (88%)                               
      Tension Lipidosis                                2 (4%)       5 (10%)                   1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
      Bile Duct, Degeneration, Hyaline                                                        1 (2%)                                
      Centrilobular, Hypertrophy                       2 (4%)                    4 (8%)      36 (72%)                               
      Centrilobular, Necrosis                                                    4 (8%)       2 (4%)                                
   Mesentery                                          (14)         (11)         (10)         (15)                                   
      Inflammation, Granulomatous                      3 (21%)      1 (9%)       2 (20%)      3 (20%)                               
      Artery, Inflammation, Chronic Active                          1 (9%)                                                          
      Fat, Necrosis                                   12 (86%)      9 (82%)      9 (90%)     12 (80%)                               
   Pancreas                                           (49)         (50)         (50)         (49)                                   
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Basophilic Focus                                              1 (2%)       1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Lipomatosis                                      1 (2%)       1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)         (49)         (50)                                   
      Hyperplasia, Squamous                            4 (8%)       4 (8%)       1 (2%)       9 (18%)                               
      Inflammation, Acute                              2 (4%)       1 (2%)       1 (2%)       4 (8%)                                
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Necrosis                                         1 (2%)       1 (2%)                    4 (8%)                                
   Stomach, Glandular                                 (49)         (49)         (48)         (48)                                   
      Hyperplasia                                                   1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Necrosis                                                                   2 (4%)                                             
   Tooth                                              (23)         (26)         (22)         (21)                                   
      Inflammation, Chronic Active                     1 (4%)                                                                       
      Malformation                                    21 (91%)     26 (100%)    22 (100%)    20 (95%)                               
      Dentine, Incisor, Dysplasia                      1 (4%)                                 1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (3)                       (1)                                    
      Inflammation, Chronic Active                     1 (100%)     1 (33%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Cardiomyopathy                                   9 (18%)      8 (16%)      7 (14%)      7 (14%)                               
      Mineralization                                                             1 (2%)       1 (2%)                                
      Artery, Inflammation, Chronic Active             1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Hyperplasia                                     23 (47%)     16 (32%)     13 (26%)     14 (28%)                               
      Hypertrophy                                     37 (76%)     42 (84%)     30 (60%)     26 (52%)                               
      Subcapsular, Hyperplasia                                                                1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      3 (6%)                                 3 (6%)                                
   Islets, Pancreatic                                 (49)         (50)         (50)         (49)                                   
      Hypertrophy                                                   2 (4%)                                                          
   Pituitary Gland                                    (48)         (50)         (50)         (49)                                   
      Cyst                                                          1 (2%)                    1 (2%)                                
      Pars Distalis, Hyperplasia                       2 (4%)       1 (2%)       3 (6%)       3 (6%)                                
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
      Pars Intermedia, Hypertrophy                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 (2%)       2 (4%)       1 (2%)       3 (6%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
   Preputial Gland                                    (49)         (49)         (50)         (50)                                   
      Ectasia                                         28 (57%)     24 (49%)     21 (42%)     22 (44%)                               
      Hyperplasia, Squamous                                                                   1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
   Prostate                                           (48)         (50)         (50)         (50)                                   
      Hyperplasia                                                   2 (4%)                                                          
      Inflammation, Chronic Active                                               2 (4%)                                             
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Seminal Vesicle                                    (49)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                                         1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Mineralization                                   1 (2%)       1 (2%)                                                          
      Interstitial Cell, Hyperplasia                   2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (48)                                   
      Angiectasis                                                                             1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
   Lymph Node                                         (1)                       (3)          (1)                                    
      Iliac, Infiltration Cellular, Plasma Cell                                  1 (33%)      1 (100%)                              
   Lymph Node, Mesenteric                             (49)         (48)         (50)         (47)                                   
      Angiectasis                                      2 (4%)                                                                       
      Infiltration Cellular, Plasma Cell                            2 (4%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Mixed Cell                2 (4%)                                 1 (2%)                                
   Lymph Node, Mediastinal                            (41)         (36)         (42)         (35)                                   
      Inflammation, Granulomatous                      1 (2%)                                                                       
   Spleen                                             (49)         (50)         (50)         (49)                                   
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
   Thymus                                             (44)         (44)         (42)         (40)                                   
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Inflammation, Acute                                                        1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       2 (4%)       4 (8%)                                
      Lymphatic, Angiectasis                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Degeneration, Hyaline                                                                   1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                      3 (6%)                    2 (4%)       1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 5 (10%)      2 (4%)       2 (4%)       6 (12%)                               
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)       2 (4%)                                                          
   Nose                                               (50)         (50)         (50)         (48)                                   
      Inflammation, Suppurative                        1 (2%)       2 (4%)       4 (8%)       2 (4%)                                
      Polyp, Inflammatory                                           1 (2%)                                                          
      Thrombosis                                                    2 (4%)                                                          
      Glands, Dilatation                               2 (4%)       2 (4%)       1 (2%)       3 (6%)                                
      Olfactory Epithelium, Atrophy                    1 (2%)       1 (2%)       3 (6%)                                             
      Sinus, Foreign Body                              1 (2%)                                                                       
   Trachea                                            (49)         (50)         (49)         (48)                                   
      Degeneration, Hyaline                                                                   1 (2%)                                
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (3)          (2)          (1)                                    
      Cataract                                         2 (67%)                                                                      
      Degeneration                                                  1 (33%)                                                         
      Cornea, Inflammation, Chronic Active                          1 (33%)                                                         
   Harderian Gland                                    (9)          (5)          (5)          (5)                                    
      Hyperplasia                                      1 (11%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (49)                                   
      Cyst                                                          1 (2%)                                                          
      Infarct                                          3 (6%)       2 (4%)       5 (10%)      1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 04/11/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Metaplasia, Osseous                              3 (6%)       3 (6%)       5 (10%)      2 (4%)                                
      Mineralization                                                             1 (2%)                                             
      Nephropathy                                     47 (96%)     46 (92%)     47 (94%)     41 (84%)                               
      Renal Tubule, Hyperplasia                        1 (2%)                                 2 (4%)                                
      Renal Tubule, Karyomegaly                                     1 (2%)       1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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