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TDMS Study 93026-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 04/11/02       
EXPERIMENT: 93026 TEST: 06                                                                                     TIME: 09:23:58       
TEST TYPE:  CHRONIC                                                                                            PAGE:       1        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: grumbein, sondra                                                                                  CAS: 91-17-8         
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                                                        Final#1, Revision#2                                                         
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 04/11/02       
EXPERIMENT: 93026 TEST: 06                                                                                     TIME: 09:23:58       
TEST TYPE:  CHRONIC                                                                                                                 
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: grumbein, sondra                                                                                  CAS: 91-17-8         
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 04/11/02       
EXPERIMENT: 93026 TEST: 06                                                                                     TIME: 09:23:58       
TEST TYPE:  CHRONIC                                                                                                                 
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: grumbein, sondra                                                                                  CAS: 91-17-8         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     DECALIN                                                                                      
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
Testes                                 Adenoma                                                                                      
All Organs                             Benign Tumors                                                                                
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Uterus                                 Polyp Stromal                                                                                
                                       Sarcoma Stromal or Polyp Stromal                                                             
All Organs                             Benign Tumors                                                                                
===============================================================                                                                     
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                      DECALIN                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    1/50 (2%)    0/50 (0%)    4/50 (8%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/44.56      1/45.02      0/45.00      4/44.52     |1/44.80      0/42.57      0/45.02      0/45.26      | 
|POLY-3 PERCENT (g) |     4.5%         2.2%         0.0%         9.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/40 (5%)    1/41 (2%)    0/36 (0%)    3/34 (9%)   |1/37 (3%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          634         |735 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.062      P=0.491N     P=0.262N     P=0.271     |P=0.532N     P=0.556N     P=0.511N     P=0.505N     | 
|POLY 3             |     P=0.088      P=0.496N     P=0.235N     P=0.337     |P=0.538N     P=0.510N     P=0.499N     P=0.498N     | 
|POLY 1.5           |     P=0.090      P=0.496N     P=0.233N     P=0.342     |P=0.542N     P=0.504N     P=0.500N     P=0.500N     | 
|POLY 6             |     P=0.085      P=0.496N     P=0.238N     P=0.327     |P=0.533N     P=0.518N     P=0.498N     P=0.495N     | 
|LOGISTIC REGRESSION|     P=0.085      P=0.491N     (e)          P=0.332     |P=0.532N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.092      P=0.492N     P=0.242N     P=0.349     |P=0.549N     P=0.495N     P=0.495N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/48 (4%)    0/50 (0%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/44.56      0/45.02      0/45.00      0/44.16     |2/43.80      0/42.57      2/45.02      1/45.58      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         0.0%         4.4%         2.2%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |2/36 (6%)    0/28 (0%)    2/35 (6%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      ---          735 (T)      644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.570N     P=0.295N     P=0.685      P=0.495N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.578N     P=0.243N     P=0.684N     P=0.486N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.591N     P=0.237N     P=0.685N     P=0.491N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.560N     P=0.252N     P=0.682N     P=0.479N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.592N     (e)          P=0.685      P=0.493N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.605N     P=0.237N     P=0.676N     P=0.492N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    2/50 (4%)    0/50 (0%)   |0/40 (0%)    0/42 (0%)    0/44 (0%)    0/44 (0%)    | 
|POLY-3 RATE (b)    |     0/44.58      0/44.53      2/45.00      0/44.16     |0/37.16      0/35.32      0/40.55      0/40.61      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    2/36 (6%)    0/34 (0%)   |0/31 (0%)    0/23 (0%)    0/33 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          733 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.690N     (e)          P=0.215      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.658N     (e)          P=0.239      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.652N     (e)          P=0.241      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.668N     (e)          P=0.236      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.215      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.647N     (e)          P=0.253      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    4/50 (8%)    3/50 (6%)   |3/49 (6%)    4/50 (8%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/45.71      4/45.08      4/45.00      3/44.90     |3/45.15      4/43.34      2/45.21      2/45.81      | 
|POLY-3 PERCENT (g) |     13.1%        8.9%         8.9%         6.7%        |6.7%         9.2%         4.4%         4.4%         | 
|TERMINAL (d)       |     5/40 (13%)   3/41 (7%)    4/36 (11%)   2/34 (6%)   |2/37 (5%)    2/28 (7%)    1/35 (3%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     588          718          733 (T)      467         |638          588          686          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.354N     P=0.362N     P=0.430N     P=0.309N    |P=0.320N     P=0.398      P=0.509N     P=0.501N     | 
|POLY 3             |     P=0.277N     P=0.378N     P=0.379N     P=0.251N    |P=0.342N     P=0.478      P=0.499N     P=0.493N     | 
|POLY 1.5           |     P=0.272N     P=0.377N     P=0.373N     P=0.245N    |P=0.346N     P=0.491      P=0.500N     P=0.495N     | 
|POLY 6             |     P=0.288N     P=0.377N     P=0.390N     P=0.261N    |P=0.333N     P=0.461      P=0.498N     P=0.488N     | 
|LOGISTIC REGRESSION|     P=0.276N     P=0.372N     P=0.374N     P=0.239N    |P=0.349N     P=0.527      P=0.493N     P=0.486N     | 
|COCH-ARM / FISHERS |     P=0.272N     P=0.370N     P=0.370N     P=0.243N    |P=0.348N     P=0.511      P=0.490N     P=0.490N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |1/49 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/45.45      1/45.02      1/45.00      1/44.16     |1/44.80      0/42.57      3/45.02      0/45.46      | 
|POLY-3 PERCENT (g) |     6.6%         2.2%         2.2%         2.3%        |2.2%         0.0%         6.7%         0.0%         | 
|TERMINAL (d)       |     2/40 (5%)    1/41 (2%)    1/36 (3%)    1/34 (3%)   |1/37 (3%)    0/28 (0%)    3/35 (9%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     674          733 (T)      733 (T)      733 (T)     |735 (T)      ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.441N     P=0.298N     P=0.335N     P=0.355N    |P=0.381N     P=0.556N     P=0.285      P=0.505N     | 
|POLY 3             |     P=0.392N     P=0.309N     P=0.309N     P=0.316N    |P=0.386N     P=0.510N     P=0.307      P=0.497N     | 
|POLY 1.5           |     P=0.387N     P=0.309N     P=0.306N     P=0.310N    |P=0.395N     P=0.504N     P=0.306      P=0.498N     | 
|POLY 6             |     P=0.399N     P=0.308N     P=0.314N     P=0.325N    |P=0.371N     P=0.518N     P=0.308      P=0.495N     | 
|LOGISTIC REGRESSION|     P=0.400N     P=0.306N     P=0.307N     P=0.315N    |P=0.381N     (e)          P=0.285      (e)          | 
|COCH-ARM / FISHERS |     P=0.385N     P=0.309N     P=0.309N     P=0.309N    |P=0.403N     P=0.495N     P=0.316      P=0.495N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   5/50 (10%)   5/50 (10%)   4/50 (8%)   |4/49 (8%)    4/50 (8%)    5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     9/45.94      5/45.08      5/45.00      4/44.90     |4/45.15      4/43.34      5/45.21      2/45.81      | 
|POLY-3 PERCENT (g) |     19.6%        11.1%        11.1%        8.9%        |8.9%         9.2%         11.1%        4.4%         | 
|TERMINAL (d)       |     7/40 (18%)   4/41 (10%)   5/36 (14%)   3/34 (9%)   |3/37 (8%)    2/28 (7%)    4/35 (11%)   1/36 (3%)    | 
|FIRST INCIDENCE    |     588          718          733 (T)      467         |638          588          686          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.268N     P=0.189N     P=0.249N     P=0.177N    |P=0.209N     P=0.527      P=0.478      P=0.343N     | 
|POLY 3             |     P=0.189N     P=0.202N     P=0.203N     P=0.123N    |P=0.225N     P=0.621      P=0.501      P=0.330N     | 
|POLY 1.5           |     P=0.184N     P=0.201N     P=0.197N     P=0.118N    |P=0.232N     P=0.634      P=0.500      P=0.332N     | 
|POLY 6             |     P=0.200N     P=0.203N     P=0.215N     P=0.133N    |P=0.213N     P=0.604      P=0.502      P=0.325N     | 
|LOGISTIC REGRESSION|     P=0.191N     P=0.195N     P=0.196N     P=0.116N    |P=0.234N     P=0.629N     P=0.503      P=0.326N     | 
|COCH-ARM / FISHERS |     P=0.185N     P=0.194N     P=0.194N     P=0.117N    |P=0.235N     P=0.631N     P=0.513      P=0.329N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.23      1/45.02      2/45.13      0/44.16     |0/44.80      0/42.57      0/45.02      0/45.46      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    1/41 (2%)    1/36 (3%)    0/34 (0%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      699          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.511N     P=0.505      P=0.231      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.481N     P=0.499      P=0.237      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.476N     P=0.499      P=0.238      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.489N     P=0.500      P=0.235      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.483N     P=0.505      P=0.236      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.473N     P=0.500      P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    2/50 (4%)    2/49 (4%)   |1/49 (2%)    0/47 (0%)    1/50 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/44.56      0/45.02      2/45.71      2/43.64     |1/45.08      0/40.98      1/45.11      0/45.26      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.4%         4.6%        |2.2%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    0/41 (0%)    0/36 (0%)    1/34 (3%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          612          731         |659          ---          714          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.254      P=0.495N     P=0.485      P=0.447     |P=0.454N     P=0.530N     P=0.760      P=0.495N     | 
|POLY 3             |     P=0.282      P=0.498N     P=0.509      P=0.493     |P=0.463N     P=0.519N     P=0.760N     P=0.499N     | 
|POLY 1.5           |     P=0.286      P=0.498N     P=0.509      P=0.497     |P=0.469N     P=0.515N     P=0.760      P=0.500N     | 
|POLY 6             |     P=0.273      P=0.497N     P=0.507      P=0.486     |P=0.456N     P=0.525N     P=0.760N     P=0.497N     | 
|LOGISTIC REGRESSION|     P=0.287      (e)          P=0.499      P=0.471     |P=0.476N     P=0.489N     P=0.754N     P=0.489N     | 
|COCH-ARM / FISHERS |     P=0.287      P=0.495N     P=0.508      P=0.500     |P=0.474N     P=0.510N     P=0.747N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.23      3/45.02      0/45.00      2/44.16     |0/44.80      0/42.57      0/45.02      1/45.46      | 
|POLY-3 PERCENT (g) |     2.2%         6.7%         0.0%         4.5%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/40 (3%)    3/41 (7%)    0/36 (0%)    2/34 (6%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          733 (T)     |---          ---          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.499      P=0.314      P=0.521N     P=0.443     |P=0.243      (e)          (e)          P=0.495      | 
|POLY 3             |     P=0.556      P=0.304      P=0.501N     P=0.492     |P=0.234      (e)          (e)          P=0.503      | 
|POLY 1.5           |     P=0.561      P=0.303      P=0.500N     P=0.496     |P=0.231      (e)          (e)          P=0.502      | 
|POLY 6             |     P=0.550      P=0.306      P=0.503N     P=0.484     |P=0.239      (e)          (e)          P=0.505      | 
|LOGISTIC REGRESSION|     P=0.499      P=0.314      (e)          P=0.443     |(e)          (e)          (e)          P=0.495      | 
|COCH-ARM / FISHERS |     P=0.565      P=0.309      P=0.500N     P=0.500     |P=0.229      (e)          (e)          P=0.505      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  22/50 (44%)  14/50 (28%)  27/50 (54%) |7/49 (14%)   13/50 (26%)  8/50 (16%)   17/50 (34%)  | 
|POLY-3 RATE (b)    |     22/47.09     22/46.93     14/47.39     27/45.45    |7/44.80      13/43.76     8/45.41      17/45.68     | 
|POLY-3 PERCENT (g) |     46.7%        46.9%        29.5%        59.4%       |15.6%        29.7%        17.6%        37.2%        | 
|TERMINAL (d)       |     18/40 (45%)  19/41 (46%)  8/36 (22%)   21/34 (62%) |7/37 (19%)   9/28 (32%)   6/35 (17%)   14/36 (39%)  | 
|FIRST INCIDENCE    |     476          495          448          605         |735 (T)      532          652          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.030 *    P=0.545N     P=0.143N     P=0.079     |P=0.047 *    P=0.032 *    P=0.462      P=0.015 *    | 
|POLY 3             |     P=0.062      P=0.576      P=0.063N     P=0.151     |P=0.024 *    P=0.089      P=0.511      P=0.016 *    | 
|POLY 1.5           |     P=0.076      P=0.572      P=0.064N     P=0.177     |P=0.023 *    P=0.099      P=0.506      P=0.016 *    | 
|POLY 6             |     P=0.048 *    P=0.581      P=0.066N     P=0.122     |P=0.026 *    P=0.079      P=0.521      P=0.017 *    | 
|LOGISTIC REGRESSION|     P=0.094      P=0.574      P=0.072N     P=0.183     |P=0.033 *    P=0.078      P=0.509      P=0.019 *    | 
|COCH-ARM / FISHERS |     P=0.098      P=0.580N     P=0.072N     P=0.212     |P=0.025 *    P=0.115      P=0.517      P=0.019 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  7/50 (14%)   10/50 (20%)  11/50 (22%) |4/49 (8%)    16/50 (32%)  6/50 (12%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     10/47.33     7/47.13      10/46.98     11/46.68    |4/44.92      16/45.09     6/45.89      5/45.87      | 
|POLY-3 PERCENT (g) |     21.1%        14.9%        21.3%        23.6%       |8.9%         35.5%        13.1%        10.9%        | 
|TERMINAL (d)       |     6/40 (15%)   3/41 (7%)    5/36 (14%)   4/34 (12%)  |3/37 (8%)    7/28 (25%)   3/35 (9%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     384          497          561          552         |703          488          594          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.242      P=0.309N     P=0.534      P=0.408     |P=0.108N     P<0.001 **   P=0.357      P=0.499      | 
|POLY 3             |     P=0.298      P=0.300N     P=0.592      P=0.486     |P=0.115N     P=0.002 **   P=0.383      P=0.513      | 
|POLY 1.5           |     P=0.306      P=0.303N     P=0.595      P=0.492     |P=0.119N     P=0.002 **   P=0.377      P=0.509      | 
|POLY 6             |     P=0.288      P=0.294N     P=0.587      P=0.479     |P=0.107N     P=0.002 **   P=0.392      P=0.523      | 
|LOGISTIC REGRESSION|     P=0.312      P=0.265N     P=0.589      P=0.521     |P=0.125N     P=0.003 **   P=0.377      P=0.509      | 
|COCH-ARM / FISHERS |     P=0.310      P=0.298N     P=0.598N     P=0.500     |P=0.125N     P=0.003 **   P=0.383      P=0.513      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  8/50 (16%)   10/50 (20%)  12/50 (24%) |4/49 (8%)    16/50 (32%)  6/50 (12%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     10/47.33     8/47.13      10/46.98     12/46.74    |4/44.92      16/45.09     6/45.89      6/45.90      | 
|POLY-3 PERCENT (g) |     21.1%        17.0%        21.3%        25.7%       |8.9%         35.5%        13.1%        13.1%        | 
|TERMINAL (d)       |     6/40 (15%)   4/41 (10%)   5/36 (14%)   4/34 (12%)  |3/37 (8%)    7/28 (25%)   3/35 (9%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     384          497          561          552         |703          488          594          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.193      P=0.403N     P=0.534      P=0.325     |P=0.178N     P<0.001 **   P=0.357      P=0.372      | 
|POLY 3             |     P=0.243      P=0.401N     P=0.592      P=0.391     |P=0.198N     P=0.002 **   P=0.383      P=0.383      | 
|POLY 1.5           |     P=0.249      P=0.404N     P=0.595      P=0.397     |P=0.203N     P=0.002 **   P=0.377      P=0.379      | 
|POLY 6             |     P=0.234      P=0.394N     P=0.587      P=0.386     |P=0.187N     P=0.002 **   P=0.392      P=0.393      | 
|LOGISTIC REGRESSION|     P=0.254      P=0.366N     P=0.589      P=0.422     |P=0.208N     P=0.003 **   P=0.377      P=0.379      | 
|COCH-ARM / FISHERS |     P=0.253      P=0.398N     P=0.598N     P=0.405     |P=0.209N     P=0.003 **   P=0.383      P=0.383      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/50 (56%)  26/50 (52%)  22/50 (44%)  34/50 (68%) |11/49 (22%)  27/50 (54%)  14/50 (28%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     28/48.71     26/48.44     22/48.98     34/47.10    |11/44.92     27/46.25     14/46.28     20/46.03     | 
|POLY-3 PERCENT (g) |     57.5%        53.7%        44.9%        72.2%       |24.5%        58.4%        30.3%        43.5%        | 
|TERMINAL (d)       |     21/40 (53%)  20/41 (49%)  12/36 (33%)  24/34 (71%) |10/37 (27%)  15/28 (54%)  9/35 (26%)   16/36 (44%)  | 
|FIRST INCIDENCE    |     384          495          448          552         |703          488          594          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.018 *    P=0.404N     P=0.298N     P=0.061     |P=0.473      P<0.001 **   P=0.291      P=0.040 *    | 
|POLY 3             |     P=0.026 *    P=0.431N     P=0.148N     P=0.094     |P=0.339      P<0.001 **   P=0.351      P=0.043 *    | 
|POLY 1.5           |     P=0.034 *    P=0.436N     P=0.150N     P=0.114     |P=0.333      P<0.001 **   P=0.337      P=0.042 *    | 
|POLY 6             |     P=0.020 *    P=0.423N     P=0.149N     P=0.076     |P=0.360      P<0.001 **   P=0.374      P=0.048 *    | 
|LOGISTIC REGRESSION|     P=0.050      P=0.412N     P=0.146N     P=0.149     |P=0.363      P<0.001 **   P=0.326      P=0.048 *    | 
|COCH-ARM / FISHERS |     P=0.048 *    P=0.421N     P=0.159N     P=0.151     |P=0.346      P<0.001 **   P=0.343      P=0.047 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/50 (56%)  27/50 (54%)  22/50 (44%)  34/50 (68%) |11/49 (22%)  27/50 (54%)  14/50 (28%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     28/48.71     27/48.44     22/48.98     34/47.10    |11/44.92     27/46.25     14/46.28     21/46.07     | 
|POLY-3 PERCENT (g) |     57.5%        55.7%        44.9%        72.2%       |24.5%        58.4%        30.3%        45.6%        | 
|TERMINAL (d)       |     21/40 (53%)  21/41 (51%)  12/36 (33%)  24/34 (71%) |10/37 (27%)  15/28 (54%)  9/35 (26%)   16/36 (44%)  | 
|FIRST INCIDENCE    |     384          495          448          552         |703          488          594          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.022 *    P=0.471N     P=0.298N     P=0.061     |P=0.387      P<0.001 **   P=0.291      P=0.027 *    | 
|POLY 3             |     P=0.033 *    P=0.512N     P=0.148N     P=0.094     |P=0.250      P<0.001 **   P=0.351      P=0.027 *    | 
|POLY 1.5           |     P=0.042 *    P=0.517N     P=0.150N     P=0.114     |P=0.245      P<0.001 **   P=0.337      P=0.026 *    | 
|POLY 6             |     P=0.025 *    P=0.504N     P=0.149N     P=0.076     |P=0.269      P<0.001 **   P=0.374      P=0.030 *    | 
|LOGISTIC REGRESSION|     P=0.060      P=0.492N     P=0.146N     P=0.149     |P=0.276      P<0.001 **   P=0.326      P=0.031 *    | 
|COCH-ARM / FISHERS |     P=0.059      P=0.500N     P=0.159N     P=0.151     |P=0.261      P<0.001 **   P=0.343      P=0.031 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/50 (10%)   4/50 (8%)    2/50 (4%)   |1/49 (2%)    4/50 (8%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     8/45.54      5/45.02      4/45.13      2/44.55     |1/44.80      4/42.98      0/45.02      4/45.58      | 
|POLY-3 PERCENT (g) |     17.6%        11.1%        8.9%         4.5%        |2.2%         9.3%         0.0%         8.8%         | 
|TERMINAL (d)       |     7/40 (18%)   5/41 (12%)   3/36 (8%)    1/34 (3%)   |1/37 (3%)    3/28 (11%)   0/35 (0%)    2/36 (6%)    | 
|FIRST INCIDENCE    |     649          733 (T)      699          622         |735 (T)      616          ---          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.099N     P=0.262N     P=0.225N     P=0.079N    |P=0.255      P=0.117      P=0.511N     P=0.183      | 
|POLY 3             |     P=0.063N     P=0.283N     P=0.180N     P=0.048N*   |P=0.217      P=0.166      P=0.499N     P=0.184      | 
|POLY 1.5           |     P=0.061N     P=0.282N     P=0.178N     P=0.047N*   |P=0.216      P=0.174      P=0.500N     P=0.183      | 
|POLY 6             |     P=0.067N     P=0.281N     P=0.186N     P=0.051N    |P=0.221      P=0.157      P=0.498N     P=0.188      | 
|LOGISTIC REGRESSION|     P=0.067N     P=0.272N     P=0.183N     P=0.050N    |P=0.230      P=0.168      (e)          P=0.188      | 
|COCH-ARM / FISHERS |     P=0.062N     P=0.277N     P=0.178N     P=0.046N*   |P=0.219      P=0.187      P=0.495N     P=0.187      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   8/50 (16%)   6/50 (12%)   12/50 (24%) |6/49 (12%)   3/50 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     8/45.54      8/45.70      6/45.39      12/46.70    |6/45.36      3/42.57      1/45.26      1/45.46      | 
|POLY-3 PERCENT (g) |     17.6%        17.5%        13.2%        25.7%       |13.2%        7.1%         2.2%         2.2%         | 
|TERMINAL (d)       |     7/40 (18%)   7/41 (17%)   5/36 (14%)   7/34 (21%)  |4/37 (11%)   3/28 (11%)   0/35 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     649          497          623          469         |610          735 (T)      672          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.066      P=0.587N     P=0.462N     P=0.153     |P=0.069N     P=0.376N     P=0.067N     P=0.063N     | 
|POLY 3             |     P=0.133      P=0.605N     P=0.389N     P=0.244     |P=0.071N     P=0.274N     P=0.056N     P=0.055N     | 
|POLY 1.5           |     P=0.130      P=0.607      P=0.386N     P=0.240     |P=0.074N     P=0.256N     P=0.056N     P=0.055N     | 
|POLY 6             |     P=0.133      P=0.599N     P=0.396N     P=0.245     |P=0.066N     P=0.298N     P=0.056N     P=0.055N     | 
|LOGISTIC REGRESSION|     P=0.122      P=0.604      P=0.392N     P=0.231     |P=0.076N     P=0.271N     P=0.055N     P=0.056N     | 
|COCH-ARM / FISHERS |     P=0.122      P=0.607N     P=0.387N     P=0.227     |P=0.079N     P=0.233N     P=0.053N     P=0.053N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  13/50 (26%)  10/50 (20%)  13/50 (26%) |7/49 (14%)   7/50 (14%)   1/50 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     15/45.54     13/45.70     10/45.52     13/46.70    |7/45.36      7/42.98      1/45.26      5/45.58      | 
|POLY-3 PERCENT (g) |     32.9%        28.4%        22.0%        27.8%       |15.4%        16.3%        2.2%         11.0%        | 
|TERMINAL (d)       |     14/40 (35%)  12/41 (29%)  8/36 (22%)   8/34 (24%)  |5/37 (14%)   6/28 (21%)   0/35 (0%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     649          497          623          469         |610          616          672          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.441      P=0.383N     P=0.258N     P=0.578N    |P=0.327N     P=0.422      P=0.039N*    P=0.387N     | 
|POLY 3             |     P=0.460N     P=0.406N     P=0.173N     P=0.380N    |P=0.367N     P=0.572      P=0.030N*    P=0.376N     | 
|POLY 1.5           |     P=0.468N     P=0.412N     P=0.173N     P=0.389N    |P=0.372N     P=0.595      P=0.030N*    P=0.375N     | 
|POLY 6             |     P=0.458N     P=0.396N     P=0.177N     P=0.375N    |P=0.357N     P=0.540      P=0.030N*    P=0.372N     | 
|LOGISTIC REGRESSION|     P=0.502N     P=0.415N     P=0.185N     P=0.414N    |P=0.361N     P=0.575      P=0.031N*    P=0.368N     | 
|COCH-ARM / FISHERS |     P=0.492N     P=0.412N     P=0.178N     P=0.412N    |P=0.376N     P=0.597N     P=0.028N*    P=0.365N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/49 (2%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.23      0/45.02      0/45.00      0/44.16     |1/45.08      2/43.19      2/45.21      0/45.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         4.6%         4.4%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |0/37 (0%)    1/28 (4%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |659          532          700          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.220N     P=0.448      P=0.503      P=0.495N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.230N     P=0.485      P=0.501      P=0.498N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.232N     P=0.494      P=0.500      P=0.498N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.226N     P=0.473      P=0.502      P=0.497N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.230N     P=0.565      P=0.511      P=0.480N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.231N     P=0.508      P=0.508      P=0.495N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/49 (2%)    0/49 (0%)    3/49 (6%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.80      0/41.57      3/44.32      2/44.36      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         0.0%         6.8%         4.5%         | 
|TERMINAL (d)       |                                                        |1/37 (3%)    0/27 (0%)    3/35 (9%)    1/35 (3%)    | 
|FIRST INCIDENCE    |                                                        |735 (T)      ---          735 (T)      710          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.370      P=0.563N     P=0.285      P=0.499      | 
|POLY 3             |                                                        |P=0.353      P=0.515N     P=0.301      P=0.497      | 
|POLY 1.5           |                                                        |P=0.340      P=0.509N     P=0.300      P=0.493      | 
|POLY 6             |                                                        |P=0.373      P=0.523N     P=0.304      P=0.502      | 
|LOGISTIC REGRESSION|                                                        |P=0.366      (e)          P=0.285      P=0.500      | 
|COCH-ARM / FISHERS |                                                        |P=0.328      P=0.500N     P=0.309      P=0.492      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor: Benign, Malignant, NOS                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/49 (2%)    0/49 (0%)    1/49 (2%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.80      0/41.57      1/44.32      2/44.58      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         0.0%         2.3%         4.5%         | 
|TERMINAL (d)       |                                                        |1/37 (3%)    0/27 (0%)    1/35 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |                                                        |735 (T)      ---          735 (T)      644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.259      P=0.563N     P=0.749      P=0.492      | 
|POLY 3             |                                                        |P=0.251      P=0.515N     P=0.758      P=0.498      | 
|POLY 1.5           |                                                        |P=0.242      P=0.509N     P=0.757      P=0.494      | 
|POLY 6             |                                                        |P=0.263      P=0.523N     P=0.760      P=0.505      | 
|LOGISTIC REGRESSION|                                                        |P=0.238      (e)          P=0.749      P=0.493      | 
|COCH-ARM / FISHERS |                                                        |P=0.232      P=0.500N     P=0.753N     P=0.492      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    1/50 (2%)    0/50 (0%)    0/49 (0%)   |13/49 (27%)  8/49 (16%)   10/49 (20%)  17/50 (34%)  | 
|POLY-3 RATE (b)    |     1/43.23      1/45.02      0/45.00      0/43.63     |13/45.36     8/43.79      10/44.82     17/45.66     | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         0.0%         0.0%        |28.7%        18.3%        22.3%        37.2%        | 
|TERMINAL (d)       |     1/38 (3%)    1/41 (2%)    0/36 (0%)    0/34 (0%)   |11/37 (30%)  4/28 (14%)   8/34 (24%)   14/36 (39%)  | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          ---         |659          532          511          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.375N     P=0.745N     P=0.511N     P=0.522N    |P=0.100      P=0.351N     P=0.388N     P=0.243      | 
|POLY 3             |     P=0.350N     P=0.752N     P=0.492N     P=0.498N    |P=0.059      P=0.181N     P=0.326N     P=0.258      | 
|POLY 1.5           |     P=0.349N     P=0.752N     P=0.491N     P=0.497N    |P=0.058      P=0.173N     P=0.331N     P=0.260      | 
|POLY 6             |     P=0.351N     P=0.750N     P=0.494N     P=0.501N    |P=0.064      P=0.195N     P=0.323N     P=0.262      | 
|LOGISTIC REGRESSION|     P=0.375N     P=0.745N     (e)          (e)         |P=0.067      P=0.173N     P=0.333N     P=0.286      | 
|COCH-ARM / FISHERS |     P=0.348N     P=0.742N     P=0.490N     P=0.495N    |P=0.062      P=0.162N     P=0.317N     P=0.278      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |1/49 (2%)    1/49 (2%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.23      0/45.02      0/45.00      0/43.63     |1/44.80      1/42.30      2/44.37      2/45.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         2.4%         4.5%         4.4%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |1/37 (3%)    0/28 (0%)    0/34 (0%)    2/36 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      731          652          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.441      P=0.705      P=0.496      P=0.490      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.428      P=0.748      P=0.497      P=0.505      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.422      P=0.753      P=0.495      P=0.504      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.439      P=0.740      P=0.500      P=0.509      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.427      P=0.728      P=0.499      P=0.490      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.419      P=0.753N     P=0.500      P=0.508      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/49 (4%)    3/50 (6%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.23      0/45.02      0/45.00      0/44.16     |2/44.88      3/43.42      3/45.91      2/45.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         6.9%         6.5%         4.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |1/37 (3%)    0/28 (0%)    1/35 (3%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |714          588          356          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.473N     P=0.437      P=0.488      P=0.684N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.499N     P=0.485      P=0.510      P=0.689N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.504N     P=0.494      P=0.507      P=0.690N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.490N     P=0.473      P=0.513      P=0.685N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.507N     P=0.533      P=0.550      P=0.688N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.505N     P=0.510      P=0.510      P=0.684N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/49 (4%)    3/50 (6%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.23      0/45.02      0/45.00      0/44.16     |2/44.88      3/43.42      3/45.91      2/45.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         6.9%         6.5%         4.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |1/37 (3%)    0/28 (0%)    1/35 (3%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |714          588          356          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.473N     P=0.437      P=0.488      P=0.684N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.499N     P=0.485      P=0.510      P=0.689N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.504N     P=0.494      P=0.507      P=0.690N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.490N     P=0.473      P=0.513      P=0.685N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.507N     P=0.533      P=0.550      P=0.688N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.505N     P=0.510      P=0.510      P=0.684N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/49 (4%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.23      0/45.02      0/45.00      0/44.16     |2/44.88      2/43.09      2/45.91      1/45.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         4.6%         4.4%         2.2%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |1/37 (3%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |714          588          356          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.363N     P=0.634      P=0.684      P=0.486N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.377N     P=0.679      P=0.686N     P=0.495N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.382N     P=0.688      P=0.688N     P=0.496N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.368N     P=0.668      P=0.684N     P=0.491N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.383N     P=0.682N     P=0.643N     P=0.494N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.383N     P=0.684N     P=0.684N     P=0.492N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    3/50 (6%)    0/50 (0%)    2/49 (4%)   |1/49 (2%)    1/47 (2%)    1/50 (2%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     0/44.56      3/45.08      0/45.00      2/43.69     |1/44.88      1/41.11      1/45.16      2/44.36      | 
|POLY-3 PERCENT (g) |     0.0%         6.7%         0.0%         4.6%        |2.2%         2.4%         2.2%         4.5%         | 
|TERMINAL (d)       |     0/40 (0%)    2/41 (5%)    0/36 (0%)    1/34 (3%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    2/36 (6%)    | 
|FIRST INCIDENCE    |     ---          718          ---          718         |714          700          700          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.377      P=0.129      (e)          P=0.217     |P=0.408      P=0.726      P=0.758N     P=0.502      | 
|POLY 3             |     P=0.411      P=0.121      (e)          P=0.233     |P=0.376      P=0.741      P=0.759N     P=0.496      | 
|POLY 1.5           |     P=0.415      P=0.121      (e)          P=0.235     |P=0.371      P=0.745      P=0.760N     P=0.493      | 
|POLY 6             |     P=0.406      P=0.121      (e)          P=0.229     |P=0.385      P=0.736      P=0.758N     P=0.501      | 
|LOGISTIC REGRESSION|     P=0.401      P=0.123      (e)          P=0.227     |P=0.374      P=0.751      P=0.760N     P=0.503      | 
|COCH-ARM / FISHERS |     P=0.418      P=0.125      (e)          P=0.247     |P=0.365      P=0.742      P=0.747N     P=0.492      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     0/45.23      0/45.02      0/45.00      3/44.61     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         6.7%        |                                                    | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    2/34 (6%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          602         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   (e)          (e)          P=0.103     |                                                    | 
|POLY 3             |     P=0.007 **   (e)          (e)          P=0.116     |                                                    | 
|POLY 1.5           |     P=0.008 **   (e)          (e)          P=0.118     |                                                    | 
|POLY 6             |     P=0.007 **   (e)          (e)          P=0.113     |                                                    | 
|LOGISTIC REGRESSION|     P=0.008 **   (e)          (e)          P=0.121     |                                                    | 
|COCH-ARM / FISHERS |     P=0.008 **   (e)          (e)          P=0.121     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/49 (0%)    0/50 (0%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |0/44.80      0/42.57      2/45.11      3/45.46      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         4.4%         6.6%         | 
|TERMINAL (d)       |                                                        |0/37 (0%)    0/28 (0%)    1/35 (3%)    3/36 (8%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          714          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.059      (e)          P=0.234      P=0.116      | 
|POLY 3             |                                                        |P=0.049 *    (e)          P=0.239      P=0.121      | 
|POLY 1.5           |                                                        |P=0.047 *    (e)          P=0.238      P=0.121      | 
|POLY 6             |                                                        |P=0.053      (e)          P=0.240      P=0.123      | 
|LOGISTIC REGRESSION|                                                        |P=0.057      (e)          P=0.239      P=0.116      | 
|COCH-ARM / FISHERS |                                                        |P=0.047 *    (e)          P=0.253      P=0.125      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/49 (0%)    0/50 (0%)    2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |0/44.80      0/42.57      2/45.11      4/45.46      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         4.4%         8.8%         | 
|TERMINAL (d)       |                                                        |0/37 (0%)    0/28 (0%)    1/35 (3%)    4/36 (11%)   | 
|FIRST INCIDENCE    |                                                        |---          ---          714          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.018 *    (e)          P=0.234      P=0.059      | 
|POLY 3             |                                                        |P=0.013 *    (e)          P=0.239      P=0.062      | 
|POLY 1.5           |                                                        |P=0.013 *    (e)          P=0.238      P=0.062      | 
|POLY 6             |                                                        |P=0.014 *    (e)          P=0.240      P=0.063      | 
|LOGISTIC REGRESSION|                                                        |P=0.017 *    (e)          P=0.239      P=0.059      | 
|COCH-ARM / FISHERS |                                                        |P=0.013 *    (e)          P=0.253      P=0.061      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   2/50 (4%)    3/50 (6%)   |1/49 (2%)    2/50 (4%)    3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/45.23      6/45.08      2/45.00      3/44.22     |1/44.88      2/42.71      3/45.16      4/45.46      | 
|POLY-3 PERCENT (g) |     2.2%         13.3%        4.4%         6.8%        |2.2%         4.7%         6.6%         8.8%         | 
|TERMINAL (d)       |     1/40 (3%)    5/41 (12%)   2/36 (6%)    2/34 (6%)   |0/37 (0%)    1/28 (4%)    2/35 (6%)    4/36 (11%)   | 
|FIRST INCIDENCE    |     733 (T)      718          733 (T)      718         |714          700          700          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.546      P=0.065      P=0.463      P=0.260     |P=0.200      P=0.433      P=0.300      P=0.179      | 
|POLY 3             |     P=0.605N     P=0.055      P=0.498      P=0.297     |P=0.171      P=0.483      P=0.307      P=0.182      | 
|POLY 1.5           |     P=0.598N     P=0.055      P=0.500      P=0.302     |P=0.167      P=0.493      P=0.306      P=0.182      | 
|POLY 6             |     P=0.606      P=0.056      P=0.494      P=0.290     |P=0.178      P=0.470      P=0.309      P=0.185      | 
|LOGISTIC REGRESSION|     P=0.588      P=0.060      P=0.463      P=0.282     |P=0.184      P=0.480      P=0.307      P=0.189      | 
|COCH-ARM / FISHERS |     P=0.592N     P=0.056      P=0.500      P=0.309     |P=0.164      P=0.508      P=0.316      P=0.187      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   3/50 (6%)    3/50 (6%)   |2/49 (4%)    2/50 (4%)    3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/45.23      6/45.08      3/45.46      3/44.22     |2/44.88      2/42.71      3/45.16      4/45.46      | 
|POLY-3 PERCENT (g) |     2.2%         13.3%        6.6%         6.8%        |4.5%         4.7%         6.6%         8.8%         | 
|TERMINAL (d)       |     1/40 (3%)    5/41 (12%)   2/36 (6%)    2/34 (6%)   |1/37 (3%)    1/28 (4%)    2/35 (6%)    4/36 (11%)   | 
|FIRST INCIDENCE    |     733 (T)      718          596          718         |714          700          700          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.567      P=0.065      P=0.281      P=0.260     |P=0.292      P=0.614      P=0.487      P=0.333      | 
|POLY 3             |     P=0.582N     P=0.055      P=0.307      P=0.297     |P=0.260      P=0.676      P=0.503      P=0.343      | 
|POLY 1.5           |     P=0.574N     P=0.055      P=0.307      P=0.302     |P=0.254      P=0.686      P=0.501      P=0.342      | 
|POLY 6             |     P=0.593N     P=0.056      P=0.305      P=0.290     |P=0.271      P=0.663      P=0.505      P=0.347      | 
|LOGISTIC REGRESSION|     P=0.586N     P=0.060      P=0.305      P=0.282     |P=0.277      P=0.667      P=0.503      P=0.353      | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.056      P=0.309      P=0.309     |P=0.249      P=0.684N     P=0.510      P=0.349      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    4/50 (8%)    4/50 (8%)   |11/49 (22%)  8/50 (16%)   13/50 (26%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |     3/45.58      3/45.02      4/45.91      4/45.17     |11/46.93     8/43.98      13/45.73     14/46.77     | 
|POLY-3 PERCENT (g) |     6.6%         6.7%         8.7%         8.9%        |23.4%        18.2%        28.4%        29.9%        | 
|TERMINAL (d)       |     2/40 (5%)    3/41 (7%)    2/36 (6%)    1/34 (3%)   |6/37 (16%)   4/28 (14%)   10/35 (29%)  9/36 (25%)   | 
|FIRST INCIDENCE    |     635          733 (T)      596          552         |363          588          612          624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.373      P=0.656N     P=0.463      P=0.441     |P=0.255      P=0.479N     P=0.378      P=0.332      | 
|POLY 3             |     P=0.437      P=0.657      P=0.504      P=0.495     |P=0.190      P=0.361N     P=0.378      P=0.317      | 
|POLY 1.5           |     P=0.441      P=0.657      P=0.504      P=0.499     |P=0.179      P=0.333N     P=0.387      P=0.319      | 
|POLY 6             |     P=0.428      P=0.657      P=0.502      P=0.488     |P=0.215      P=0.395N     P=0.372      P=0.328      | 
|LOGISTIC REGRESSION|     P=0.440      P=0.661      P=0.494      P=0.504     |P=0.176      P=0.223N     P=0.438      P=0.359      | 
|COCH-ARM / FISHERS |     P=0.440      P=0.661N     P=0.500      P=0.500     |P=0.176      P=0.288N     P=0.430      P=0.343      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     32/50 (64%)  27/50 (54%)  22/50 (44%)  32/50 (64%) |28/49 (57%)  25/50 (50%)  27/50 (54%)  34/50 (68%)  | 
|POLY-3 RATE (b)    |     32/47.09     27/46.99     22/48.40     32/46.64    |28/46.33     25/45.83     27/46.74     34/46.58     | 
|POLY-3 PERCENT (g) |     68.0%        57.5%        45.5%        68.6%       |60.4%        54.6%        57.8%        73.0%        | 
|TERMINAL (d)       |     28/40 (70%)  23/41 (56%)  13/36 (36%)  24/34 (71%) |23/37 (62%)  15/28 (54%)  20/35 (57%)  26/36 (72%)  | 
|FIRST INCIDENCE    |     476          495          448          467         |568          532          511          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.085      P=0.188N     P=0.115N     P=0.248     |P=0.174      P=0.357      P=0.565      P=0.159      | 
|POLY 3             |     P=0.227      P=0.198N     P=0.019N*    P=0.562     |P=0.046 *    P=0.357N     P=0.479N     P=0.138      | 
|POLY 1.5           |     P=0.249      P=0.206N     P=0.023N*    P=0.578     |P=0.047 *    P=0.337N     P=0.489N     P=0.144      | 
|POLY 6             |     P=0.197      P=0.187N     P=0.016N*    P=0.533     |P=0.052      P=0.381N     P=0.464N     P=0.145      | 
|LOGISTIC REGRESSION|     P=0.259      P=0.215N     P=0.035N*    P=0.551     |P=0.065      P=0.380N     P=0.492N     P=0.161      | 
|COCH-ARM / FISHERS |     P=0.267      P=0.208N     P=0.035N*    P=0.582N    |P=0.059      P=0.305N     P=0.455N     P=0.182      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  20/50 (40%)  23/50 (46%)  23/50 (46%) |22/49 (45%)  28/50 (56%)  29/50 (58%)  26/50 (52%)  | 
|POLY-3 RATE (b)    |     23/48.21     20/47.19     23/47.56     23/48.45    |22/47.89     28/47.21     29/47.95     26/46.89     | 
|POLY-3 PERCENT (g) |     47.7%        42.4%        48.4%        47.5%       |45.9%        59.3%        60.5%        55.5%        | 
|TERMINAL (d)       |     16/40 (40%)  15/41 (37%)  16/36 (44%)  12/34 (35%) |13/37 (35%)  12/28 (43%)  18/35 (51%)  19/36 (53%)  | 
|FIRST INCIDENCE    |     384          497          561          469         |363          488          356          624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.251      P=0.342N     P=0.446      P=0.388     |P=0.451N     P=0.062      P=0.136      P=0.295      | 
|POLY 3             |     P=0.473      P=0.376N     P=0.556      P=0.571N    |P=0.427      P=0.133      P=0.109      P=0.235      | 
|POLY 1.5           |     P=0.467      P=0.369N     P=0.567      P=0.571N    |P=0.443      P=0.148      P=0.110      P=0.251      | 
|POLY 6             |     P=0.471      P=0.382N     P=0.537      P=0.578N    |P=0.428      P=0.123      P=0.111      P=0.230      | 
|LOGISTIC REGRESSION|     P=0.448      P=0.339N     P=0.579      P=0.551N    |P=0.502      P=0.234      P=0.141      P=0.305      | 
|COCH-ARM / FISHERS |     P=0.440      P=0.343N     P=0.579N     P=0.579N    |P=0.500      P=0.183      P=0.135      P=0.307      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DECALIN                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     43/50 (86%)  39/50 (78%)  37/50 (74%)  42/50 (84%) |39/49 (80%)  40/50 (80%)  43/50 (86%)  41/50 (82%)  | 
|POLY-3 RATE (b)    |     43/48.94     39/48.50     37/49.98     42/49.20    |39/47.89     40/47.74     43/49.00     41/47.15     | 
|POLY-3 PERCENT (g) |     87.9%        80.4%        74.0%        85.4%       |81.4%        83.8%        87.8%        87.0%        | 
|TERMINAL (d)       |     35/40 (88%)  32/41 (78%)  24/36 (67%)  29/34 (85%) |30/37 (81%)  22/28 (79%)  29/35 (83%)  31/36 (86%)  | 
|FIRST INCIDENCE    |     384          495          448          467         |363          488          356          624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113      P=0.233N     P=0.380N     P=0.251     |P=0.380N     P=0.079      P=0.219      P=0.396      | 
|POLY 3             |     P=0.440      P=0.230N     P=0.065N     P=0.472N    |P=0.327      P=0.486      P=0.278      P=0.320      | 
|POLY 1.5           |     P=0.446      P=0.235N     P=0.077N     P=0.474N    |P=0.358      P=0.508      P=0.244      P=0.350      | 
|POLY 6             |     P=0.416      P=0.221N     P=0.055N     P=0.489N    |P=0.334      P=0.484      P=0.333      P=0.329      | 
|LOGISTIC REGRESSION|     P=0.414      P=0.229N     P=0.104N     P=0.504N    |P=0.482      P=0.510      P=0.244      P=0.422      | 
|COCH-ARM / FISHERS |     P=0.414      P=0.218N     P=0.105N     P=0.500N    |P=0.478      P=0.579      P=0.282      P=0.480      | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).