National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4394

TDMS Study 93026-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 04/11/02       
EXPERIMENT: 93026 TEST: 06                                                                                     TIME: 09:27:48       
TEST TYPE:  CHRONIC                                                                                            PAGE:       1        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: grumbein, sondra                                                                                  CAS: 91-17-8         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                        Final#1, Revision#2                                                         
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 04/11/02       
EXPERIMENT: 93026 TEST: 06                                                                                     TIME: 09:27:48       
TEST TYPE:  CHRONIC                                                                                                                 
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: grumbein, sondra                                                                                  CAS: 91-17-8         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     DECALIN                                                                                      
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
Gallbladder                            Degeneration Hyaline                                                                         
Kidney                                 Nephropathy                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Erythrophagocytosis                                                                          
                                       Necrosis                                                                                     
                                       Syncytial Alteration                                                                         
Liver: Centrilobular                   Hypertrophy                                                                                  
                                       Necrosis                                                                                     
Stomach, Forestomach                   Hyperplasia                                                                                  
                                       Necrosis                                                                                     
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Nose: Glands                           Dilatation                                                                                   
Ovary                                  Cyst                                                                                         
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                      DECALIN          
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/49 (47%)  16/50 (32%)  13/50 (26%)  14/50 (28%) |6/49 (12%)   7/50 (14%)   5/50 (10%)   5/49 (10%)   | 
|POLY-3 RATE (b)    |     23/45.57     16/45.02     13/45.43     14/45.04    |6/45.51      7/43.56      5/45.07      5/45.44      | 
|POLY-3 PERCENT (g) |     50.5%        35.5%        28.6%        31.1%       |13.2%        16.1%        11.1%        11.0%        | 
|TERMINAL (d)       |     20/40 (50%)  16/41 (39%)  10/36 (28%)  10/34 (29%) |4/37 (11%)   5/28 (18%)   4/35 (11%)   4/36 (11%)   | 
|FIRST INCIDENCE    |     588          733 (T)      654          605         |610          488          723          686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292N     P=0.092N     P=0.068N     P=0.143N    |P=0.338N     P=0.341      P=0.528N     P=0.506N     | 
|POLY 3             |     P=0.118N     P=0.108N     P=0.025N*    P=0.045N*   |P=0.383N     P=0.466      P=0.507N     P=0.501N     | 
|POLY 1.5           |     P=0.113N     P=0.102N     P=0.023N*    P=0.040N*   |P=0.393N     P=0.487      P=0.504N     P=0.503N     | 
|POLY 6             |     P=0.131N     P=0.116N     P=0.029N*    P=0.054N    |P=0.367N     P=0.438      P=0.511N     P=0.496N     | 
|LOGISTIC REGRESSION|     P=0.147N     P=0.094N     P=0.026N*    P=0.049N*   |P=0.390N     P=0.524      P=0.496N     P=0.500N     | 
|COCH-ARM / FISHERS |     P=0.118N     P=0.094N     P=0.025N*    P=0.041N*   |P=0.402N     P=0.516      P=0.486N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     37/49 (76%)  42/50 (84%)  30/50 (60%)  26/50 (52%) |3/49 (6%)    8/50 (16%)   2/50 (4%)    6/49 (12%)   | 
|POLY-3 RATE (b)    |     37/47.99     42/47.18     30/46.85     26/45.66    |3/45.34      8/44.76      2/45.02      6/45.61      | 
|POLY-3 PERCENT (g) |     77.1%        89.0%        64.0%        56.9%       |6.6%         17.9%        4.4%         13.2%        | 
|TERMINAL (d)       |     31/40 (78%)  37/41 (90%)  24/36 (67%)  23/34 (68%) |2/37 (5%)    2/28 (7%)    2/35 (6%)    5/36 (14%)   | 
|FIRST INCIDENCE    |     384          495          596          467         |568          527          735 (T)      636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.042N*    P=0.249      P=0.285N     P=0.131N    |P=0.459      P=0.072      P=0.522N     P=0.236      | 
|POLY 3             |     P<0.001N**   P=0.092      P=0.115N     P=0.026N*   |P=0.408      P=0.094      P=0.503N     P=0.245      | 
|POLY 1.5           |     P<0.001N**   P=0.117      P=0.097N     P=0.018N*   |P=0.402      P=0.098      P=0.502N     P=0.242      | 
|POLY 6             |     P=0.003N**   P=0.082      P=0.134N     P=0.041N*   |P=0.419      P=0.089      P=0.504N     P=0.251      | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.185      P=0.075N     P=0.014N*   |P=0.389      P=0.143      P=0.491N     P=0.242      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.212      P=0.075N     P=0.013N*   |P=0.398      P=0.106      P=0.490N     P=0.243      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |1/48 (2%)    2/50 (4%)    2/50 (4%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     3/44.56      0/45.02      0/45.00      3/44.32     |1/43.88      2/42.88      2/45.16      2/45.26      | 
|POLY-3 PERCENT (g) |     6.7%         0.0%         0.0%         6.8%        |2.3%         4.7%         4.4%         4.4%         | 
|TERMINAL (d)       |     3/40 (8%)    0/41 (0%)    0/36 (0%)    2/34 (6%)   |0/36 (0%)    0/28 (0%)    1/35 (3%)    2/36 (6%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          ---          692         |714          658          700          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.199      P=0.117N     P=0.140N     P=0.596     |P=0.557      P=0.452      P=0.500      P=0.509      | 
|POLY 3             |     P=0.245      P=0.117N     P=0.117N     P=0.660     |P=0.533      P=0.492      P=0.510      P=0.511      | 
|POLY 1.5           |     P=0.249      P=0.117N     P=0.116N     P=0.658N    |P=0.525      P=0.501      P=0.509      P=0.508      | 
|POLY 6             |     P=0.240      P=0.116N     P=0.119N     P=0.650     |P=0.544      P=0.481      P=0.512      P=0.516      | 
|LOGISTIC REGRESSION|     P=0.230      (e)          (e)          P=0.644     |P=0.531      P=0.511      P=0.510      P=0.519      | 
|COCH-ARM / FISHERS |     P=0.251      P=0.117N     P=0.117N     P=0.651N    |P=0.518      P=0.515      P=0.515      P=0.508      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Fibrous Osteodystrophy                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/49 (6%)    3/50 (6%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.23      0/45.02      0/45.00      0/44.16     |3/45.26      3/42.66      2/45.02      2/45.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.6%         7.0%         4.4%         4.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |2/37 (5%)    2/28 (7%)    2/35 (6%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |599          714          735 (T)      714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.386N     P=0.555      P=0.522N     P=0.501N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.416N     P=0.635      P=0.502N     P=0.497N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.421N     P=0.650      P=0.502N     P=0.497N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.406N     P=0.615      P=0.503N     P=0.494N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.412N     P=0.654      P=0.494N     P=0.490N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.424N     P=0.651N     P=0.490N     P=0.490N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     1/45.45      2/45.02      1/45.00      3/44.16     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         4.4%         2.2%         6.8%        |                                                    | 
|TERMINAL (d)       |     0/40 (0%)    2/41 (5%)    1/36 (3%)    3/34 (9%)   |                                                    | 
|FIRST INCIDENCE    |     674          733 (T)      733 (T)      733 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.195      P=0.508      P=0.749      P=0.260     |                                                    | 
|POLY 3             |     P=0.241      P=0.497      P=0.758      P=0.295     |                                                    | 
|POLY 1.5           |     P=0.246      P=0.497      P=0.760      P=0.301     |                                                    | 
|POLY 6             |     P=0.232      P=0.498      P=0.755      P=0.286     |                                                    | 
|LOGISTIC REGRESSION|     P=0.230      P=0.498      P=0.762N     P=0.294     |                                                    | 
|COCH-ARM / FISHERS |     P=0.249      P=0.500      P=0.753N     P=0.309     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus                                                                                                                        | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/49 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.23      0/45.02      0/45.00      0/44.16     |2/45.23      0/42.57      0/45.02      0/45.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |1/37 (3%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |610          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.297N     P=0.281N     P=0.246N     P=0.240N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.290N     P=0.251N     P=0.238N     P=0.236N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.243N     P=0.238N     P=0.236N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.281N     P=0.261N     P=0.238N     P=0.235N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.306N     P=0.213N     P=0.219N     P=0.220N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.306N     P=0.242N     P=0.242N     P=0.242N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/3 (67%)    0/3 (0%)     0/2 (0%)     0/1 (0%)    |0/2 (0%)     0/1 (0%)     0/2 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     2/2.78       0/3.00       0/2.00       0/1.00      |0/1.76       0/0.51       0/2.00       0/0.00       | 
|POLY-3 PERCENT (g) |     72.0%        0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/2 (100%)   0/3 (0%)     0/2 (0%)     0/1 (0%)    |0/1 (0%)     0/0 (0%)     0/2 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     733 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.454N     P=0.122N     P=0.193N     P=0.362N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.513N     P=0.122N     P=0.236N     P=0.473N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.507N     P=0.139N     P=0.258N     P=0.487N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.527N     P=0.093N     P=0.195N     P=0.444N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.454N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.200N     P=0.300N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/42 (2%)    0/40 (0%)    0/41 (0%)    3/40 (8%)   |0/41 (0%)    0/40 (0%)    0/40 (0%)    0/38 (0%)    | 
|POLY-3 RATE (b)    |     1/38.85      0/35.68      0/37.23      3/38.03     |0/37.38      0/35.21      0/37.62      0/34.95      | 
|POLY-3 PERCENT (g) |     2.6%         0.0%         0.0%         7.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    0/33 (0%)    0/31 (0%)    1/33 (3%)   |0/31 (0%)    0/26 (0%)    0/31 (0%)    0/29 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          ---          552         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.047 *    P=0.512N     P=0.524N     P=0.287     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.047 *    P=0.517N     P=0.509N     P=0.297     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.046 *    P=0.515N     P=0.507N     P=0.293     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.049 *    P=0.518N     P=0.510N     P=0.303     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.037 *    (e)          (e)          P=0.282     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.045 *    P=0.512N     P=0.506N     P=0.289     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   8/50 (16%)   7/50 (14%)   7/50 (14%)  |8/49 (16%)   10/50 (20%)  13/50 (26%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |     9/47.00      8/45.02      7/45.77      7/45.83     |8/45.15      10/42.57     13/46.18     8/46.58      | 
|POLY-3 PERCENT (g) |     19.2%        17.8%        15.3%        15.3%       |17.7%        23.5%        28.2%        17.2%        | 
|TERMINAL (d)       |     5/40 (13%)   8/41 (20%)   6/36 (17%)   4/34 (12%)  |7/37 (19%)   10/28 (36%)  7/35 (20%)   6/36 (17%)   | 
|FIRST INCIDENCE    |     421          733 (T)      448          469         |638          735 (T)      612          432          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.515N     P=0.487N     P=0.454N     P=0.482N    |P=0.324N     P=0.177      P=0.156      P=0.591      | 
|POLY 3             |     P=0.398N     P=0.539N     P=0.415N     P=0.414N    |P=0.344N     P=0.343      P=0.174      P=0.581N     | 
|POLY 1.5           |     P=0.393N     P=0.527N     P=0.403N     P=0.403N    |P=0.368N     P=0.373      P=0.168      P=0.588N     | 
|POLY 6             |     P=0.411N     P=0.549N     P=0.436N     P=0.432N    |P=0.312N     P=0.304      P=0.185      P=0.568N     | 
|LOGISTIC REGRESSION|     P=0.392N     P=0.500N     P=0.400N     P=0.379N    |P=0.375N     P=0.281      P=0.166      P=0.590N     | 
|COCH-ARM / FISHERS |     P=0.394N     P=0.500N     P=0.393N     P=0.393N    |P=0.392N     P=0.416      P=0.176      P=0.590N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Ileum                                                                                                           | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    1/48 (2%)    0/47 (0%)    1/46 (2%)   |0/47 (0%)    2/45 (4%)    0/49 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     0/42.85      1/43.68      0/42.80      1/41.48     |0/43.38      2/40.27      0/45.02      0/43.41      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         2.4%        |0.0%         5.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/41 (2%)    0/35 (0%)    1/34 (3%)   |0/37 (0%)    1/28 (4%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      ---          733 (T)     |---          700          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443      P=0.510      (e)          P=0.473     |P=0.371N     P=0.193      (e)          (e)          | 
|POLY 3             |     P=0.466      P=0.504      (e)          P=0.494     |P=0.392N     P=0.221      (e)          (e)          | 
|POLY 1.5           |     P=0.469      P=0.505      (e)          P=0.496     |P=0.390N     P=0.224      (e)          (e)          | 
|POLY 6             |     P=0.462      P=0.504      (e)          P=0.490     |P=0.395N     P=0.215      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.510      (e)          P=0.473     |P=0.386N     P=0.220      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.473      P=0.511      (e)          P=0.500     |P=0.387N     P=0.237      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |0/49 (0%)    0/47 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/44.56      2/45.02      0/45.00      0/43.63     |0/44.80      0/40.98      0/45.02      0/45.26      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    2/41 (5%)    0/36 (0%)    0/34 (0%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.425N     P=0.244      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.396N     P=0.239      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.394N     P=0.240      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.397N     P=0.240      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.244      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.392N     P=0.253      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    2/50 (4%)    5/50 (10%)   1/49 (2%)   |4/49 (8%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.56      2/45.02      5/45.00      1/43.63     |4/44.94      2/42.61      0/45.02      0/45.46      | 
|POLY-3 PERCENT (g) |     6.7%         4.4%         11.1%        2.3%        |8.9%         4.7%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/40 (8%)    2/41 (5%)    5/36 (14%)   1/34 (3%)   |3/37 (8%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |700          728          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.323N     P=0.489N     P=0.299      P=0.365N    |P=0.059N     P=0.451N     P=0.069N     P=0.066N     | 
|POLY 3             |     P=0.263N     P=0.495N     P=0.362      P=0.313N    |P=0.056N     P=0.362N     P=0.060N     P=0.059N     | 
|POLY 1.5           |     P=0.258N     P=0.495N     P=0.366      P=0.308N    |P=0.058N     P=0.348N     P=0.060N     P=0.059N     | 
|POLY 6             |     P=0.274N     P=0.494N     P=0.353      P=0.320N    |P=0.054N     P=0.381N     P=0.059N     P=0.057N     | 
|LOGISTIC REGRESSION|     P=0.323N     P=0.489N     P=0.299      P=0.365N    |P=0.056N     P=0.391N     P=0.061N     P=0.059N     | 
|COCH-ARM / FISHERS |     P=0.256N     P=0.490N     P=0.369      P=0.309N    |P=0.062N     P=0.329N     P=0.056N     P=0.056N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    3/50 (6%)    5/50 (10%)   2/49 (4%)   |4/49 (8%)    1/50 (2%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     3/44.56      3/45.02      5/45.55      2/43.63     |4/44.88      1/42.57      1/45.02      3/45.46      | 
|POLY-3 PERCENT (g) |     6.7%         6.7%         11.0%        4.6%        |8.9%         2.4%         2.2%         6.6%         | 
|TERMINAL (d)       |     3/40 (8%)    3/41 (7%)    4/36 (11%)   2/34 (6%)   |3/37 (8%)    1/28 (4%)    1/35 (3%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      561          733 (T)     |714          735 (T)      735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.460N     P=0.652N     P=0.309      P=0.574N    |P=0.550      P=0.264N     P=0.195N     P=0.507N     | 
|POLY 3             |     P=0.389N     P=0.658N     P=0.369      P=0.510N    |P=0.531      P=0.195N     P=0.178N     P=0.493N     | 
|POLY 1.5           |     P=0.382N     P=0.657N     P=0.370      P=0.504N    |P=0.521      P=0.186N     P=0.178N     P=0.494N     | 
|POLY 6             |     P=0.402N     P=0.657N     P=0.363      P=0.519N    |P=0.547      P=0.207N     P=0.176N     P=0.488N     | 
|LOGISTIC REGRESSION|     P=0.390N     P=0.652N     P=0.365      P=0.574N    |P=0.552      P=0.221N     P=0.175N     P=0.480N     | 
|COCH-ARM / FISHERS |     P=0.378N     P=0.651N     P=0.369      P=0.500N    |P=0.510      P=0.175N     P=0.175N     P=0.489N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     47/49 (96%)  46/50 (92%)  47/50 (94%)  41/49 (84%) |45/49 (92%)  40/50 (80%)  40/50 (80%)  41/50 (82%)  | 
|POLY-3 RATE (b)    |     47/49.00     46/48.42     47/49.88     41/47.43    |45/49.00     40/47.40     40/48.70     41/47.86     | 
|POLY-3 PERCENT (g) |     95.9%        95.0%        94.2%        86.5%       |91.8%        84.4%        82.1%        85.7%        | 
|TERMINAL (d)       |     38/40 (95%)  39/41 (95%)  34/36 (94%)  30/34 (88%) |33/37 (89%)  25/28 (89%)  27/35 (77%)  31/36 (86%)  | 
|FIRST INCIDENCE    |     384          495          448          467         |363          527          356          309          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527      P=0.421N     P=0.285      P=0.577N    |P=0.197N     P=0.281      P=0.339N     P=0.317N     | 
|POLY 3             |     P=0.033N*    P=0.608N     P=0.530N     P=0.088N    |P=0.424N     P=0.200N     P=0.129N     P=0.257N     | 
|POLY 1.5           |     P=0.023N*    P=0.541N     P=0.520N     P=0.065N    |P=0.392N     P=0.145N     P=0.123N     P=0.204N     | 
|POLY 6             |     P=0.060N     P=0.658N     P=0.549N     P=0.134N    |P=0.444N     P=0.273N     P=0.139N     P=0.309N     | 
|LOGISTIC REGRESSION|     P=0.021N*    P=0.389N     P=0.494N     P=0.048N*   |P=0.331N     P=0.109N     P=0.091N     P=0.140N     | 
|COCH-ARM / FISHERS |     P=0.025N*    P=0.349N     P=0.510N     P=0.046N*   |P=0.339N     P=0.080N     P=0.080N     P=0.125N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    0/50 (0%)    2/49 (4%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.56      0/45.02      0/45.00      2/43.67     |1/45.08      0/42.57      0/45.02      0/45.46      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         4.6%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    0/41 (0%)    0/36 (0%)    1/34 (3%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          ---          723         |659          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.147      P=0.495N     P=0.521N     P=0.453     |P=0.533N     P=0.530N     P=0.500N     P=0.495N     | 
|POLY 3             |     P=0.170      P=0.498N     P=0.498N     P=0.493     |P=0.534N     P=0.511N     P=0.500N     P=0.498N     | 
|POLY 1.5           |     P=0.172      P=0.498N     P=0.496N     P=0.497     |P=0.538N     P=0.505N     P=0.500N     P=0.498N     | 
|POLY 6             |     P=0.167      P=0.497N     P=0.501N     P=0.486     |P=0.529N     P=0.520N     P=0.500N     P=0.497N     | 
|LOGISTIC REGRESSION|     P=0.159      (e)          (e)          P=0.478     |P=0.546N     P=0.472N     P=0.479N     P=0.480N     | 
|COCH-ARM / FISHERS |     P=0.172      P=0.495N     P=0.495N     P=0.500     |P=0.545N     P=0.495N     P=0.495N     P=0.495N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   6/50 (12%)   13/50 (26%)  13/50 (26%) |8/49 (16%)   7/50 (14%)   6/50 (12%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     9/45.23      6/45.02      13/45.42     13/44.72    |8/45.74      7/43.10      6/45.16      3/45.54      | 
|POLY-3 PERCENT (g) |     19.9%        13.3%        28.6%        29.1%       |17.5%        16.2%        13.3%        6.6%         | 
|TERMINAL (d)       |     9/40 (23%)   6/41 (15%)   11/36 (31%)  9/34 (27%)  |5/37 (14%)   6/28 (21%)   5/35 (14%)   2/36 (6%)    | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      654          634         |599          571          700          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.044 *    P=0.267N     P=0.162      P=0.136     |P=0.063N     P=0.532      P=0.417N     P=0.109N     | 
|POLY 3             |     P=0.099      P=0.290N     P=0.234      P=0.221     |P=0.073N     P=0.550N     P=0.396N     P=0.099N     | 
|POLY 1.5           |     P=0.105      P=0.292N     P=0.236      P=0.229     |P=0.076N     P=0.522N     P=0.393N     P=0.098N     | 
|POLY 6             |     P=0.090      P=0.284N     P=0.230      P=0.211     |P=0.067N     P=0.588N     P=0.401N     P=0.099N     | 
|LOGISTIC REGRESSION|     P=0.077      P=0.267N     P=0.210      P=0.189     |P=0.073N     P=0.510N     P=0.381N     P=0.095N     | 
|COCH-ARM / FISHERS |     P=0.110      P=0.288N     P=0.235      P=0.235     |P=0.078N     P=0.483N     P=0.371N     P=0.094N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  21/50 (42%)  16/50 (32%)  21/50 (42%) |2/49 (4%)    2/50 (4%)    4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     17/45.23     21/45.71     16/45.00     21/45.29    |2/44.80      2/42.90      4/45.43      1/45.46      | 
|POLY-3 PERCENT (g) |     37.6%        45.9%        35.6%        46.4%       |4.5%         4.7%         8.8%         2.2%         | 
|TERMINAL (d)       |     17/40 (43%)  20/41 (49%)  16/36 (44%)  19/34 (56%) |2/37 (5%)    1/28 (4%)    1/35 (3%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     733 (T)      495          733 (T)      467         |735 (T)      644          686          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.097      P=0.293      P=0.524      P=0.096     |P=0.312N     P=0.610      P=0.333      P=0.510N     | 
|POLY 3             |     P=0.303      P=0.274      P=0.507N     P=0.261     |P=0.334N     P=0.678      P=0.344      P=0.495N     | 
|POLY 1.5           |     P=0.315      P=0.267      P=0.500N     P=0.269     |P=0.341N     P=0.687      P=0.340      P=0.496N     | 
|POLY 6             |     P=0.280      P=0.289      P=0.524N     P=0.245     |P=0.322N     P=0.667      P=0.349      P=0.491N     | 
|LOGISTIC REGRESSION|     P=0.237      P=0.262      P=0.524      P=0.208     |P=0.338N     P=0.683      P=0.339      P=0.510N     | 
|COCH-ARM / FISHERS |     P=0.313      P=0.268      P=0.500N     P=0.268     |P=0.345N     P=0.684N     P=0.349      P=0.492N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  9/50 (18%)   7/50 (14%)   19/50 (38%) |8/49 (16%)   6/50 (12%)   11/50 (22%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |     10/45.45     9/45.57      7/45.46      19/44.90    |8/45.64      6/42.86      11/45.88     11/45.54     | 
|POLY-3 PERCENT (g) |     22.0%        19.8%        15.4%        42.3%       |17.5%        14.0%        24.0%        24.2%        | 
|TERMINAL (d)       |     9/40 (23%)   8/41 (20%)   6/36 (17%)   18/34 (53%) |6/37 (16%)   5/28 (18%)   8/35 (23%)   10/36 (28%)  | 
|FIRST INCIDENCE    |     674          561          596          467         |610          658          612          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.480N     P=0.373N     P=0.010 *   |P=0.258      P=0.574N     P=0.282      P=0.294      | 
|POLY 3             |     P=0.003 **   P=0.498N     P=0.295N     P=0.030 *   |P=0.203      P=0.436N     P=0.308      P=0.302      | 
|POLY 1.5           |     P=0.003 **   P=0.502N     P=0.294N     P=0.034 *   |P=0.196      P=0.409N     P=0.306      P=0.306      | 
|POLY 6             |     P=0.002 **   P=0.489N     P=0.302N     P=0.024 *   |P=0.218      P=0.471N     P=0.313      P=0.301      | 
|LOGISTIC REGRESSION|     P=0.003 **   P=0.503N     P=0.304N     P=0.027 *   |P=0.213      P=0.414N     P=0.313      P=0.318      | 
|COCH-ARM / FISHERS |     P=0.004 **   P=0.500N     P=0.298N     P=0.038 *   |P=0.193      P=0.371N     P=0.323      P=0.323      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Erythrophagocytosis                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    9/50 (18%)  |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.23      0/45.02      0/45.00      9/44.52     |0/44.80      0/42.57      0/45.02      0/45.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         20.2%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    8/34 (24%)  |0/37 (0%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          634         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          (e)          P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          (e)          P=0.002 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          (e)          P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          (e)          P=0.002 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          (e)          P<0.001 **  |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    3/50 (6%)   |2/49 (4%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.23      0/45.02      3/45.42      3/44.16     |2/45.21      0/42.57      2/45.12      2/45.46      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         6.6%         6.8%        |4.4%         0.0%         4.4%         4.4%         | 
|TERMINAL (d)       |     1/40 (3%)    0/41 (0%)    2/36 (6%)    3/34 (9%)   |1/37 (3%)    0/28 (0%)    1/35 (3%)    2/36 (6%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          612          733 (T)     |616          ---          710          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.111      P=0.495N     P=0.277      P=0.249     |P=0.474      P=0.278N     P=0.685      P=0.690      | 
|POLY 3             |     P=0.142      P=0.501N     P=0.307      P=0.297     |P=0.458      P=0.251N     P=0.693      P=0.692N     | 
|POLY 1.5           |     P=0.146      P=0.501N     P=0.307      P=0.302     |P=0.449      P=0.243N     P=0.693      P=0.691N     | 
|POLY 6             |     P=0.134      P=0.500N     P=0.305      P=0.289     |P=0.474      P=0.261N     P=0.694      P=0.690N     | 
|LOGISTIC REGRESSION|     P=0.143      (e)          P=0.305      P=0.249     |P=0.444      P=0.215N     P=0.687N     P=0.688N     | 
|COCH-ARM / FISHERS |     P=0.149      P=0.500N     P=0.309      P=0.309     |P=0.440      P=0.242N     P=0.684N     P=0.684N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    2/50 (4%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/45.23      0/45.02      1/45.00      0/44.16     |0/44.80      2/42.99      0/45.02      3/45.58      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.2%         0.0%        |0.0%         4.7%         0.0%         6.6%         | 
|TERMINAL (d)       |     1/40 (3%)    0/41 (0%)    1/36 (3%)    0/34 (0%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          733 (T)      ---         |---          658          ---          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.516N     P=0.495N     P=0.738      P=0.532N    |P=0.127      P=0.212      (e)          P=0.127      | 
|POLY 3             |     P=0.482N     P=0.501N     P=0.760      P=0.505N    |P=0.104      P=0.228      (e)          P=0.122      | 
|POLY 1.5           |     P=0.479N     P=0.501N     P=0.760N     P=0.502N    |P=0.104      P=0.233      (e)          P=0.121      | 
|POLY 6             |     P=0.488N     P=0.500N     P=0.757      P=0.509N    |P=0.106      P=0.222      (e)          P=0.124      | 
|LOGISTIC REGRESSION|     P=0.516N     (e)          P=0.738      (e)         |P=0.107      P=0.253      (e)          P=0.124      | 
|COCH-ARM / FISHERS |     P=0.478N     P=0.500N     P=0.753N     P=0.500N    |P=0.106      P=0.253      (e)          P=0.125      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/49 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.23      1/45.02      0/45.00      0/44.16     |1/44.80      2/42.86      0/45.02      0/45.46      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |2.2%         4.7%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    1/41 (2%)    0/36 (0%)    0/34 (0%)   |1/37 (3%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |735 (T)      658          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.637N     P=0.505      (e)          (e)         |P=0.229N     P=0.429      P=0.511N     P=0.505N     | 
|POLY 3             |     P=0.610N     P=0.499      (e)          (e)         |P=0.240N     P=0.485      P=0.499N     P=0.497N     | 
|POLY 1.5           |     P=0.610N     P=0.499      (e)          (e)         |P=0.239N     P=0.494      P=0.500N     P=0.498N     | 
|POLY 6             |     P=0.610N     P=0.500      (e)          (e)         |P=0.240N     P=0.474      P=0.498N     P=0.495N     | 
|LOGISTIC REGRESSION|     (e)          P=0.505      (e)          (e)         |P=0.236N     P=0.492      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.608N     P=0.500      (e)          (e)         |P=0.238N     P=0.508      P=0.495N     P=0.495N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   6/50 (12%)   9/50 (18%)   3/50 (6%)   |16/49 (33%)  11/50 (22%)  16/50 (32%)  16/50 (32%)  | 
|POLY-3 RATE (b)    |     5/46.04      6/45.02      9/45.00      3/44.16     |16/45.63     11/44.37     16/45.44     16/45.69     | 
|POLY-3 PERCENT (g) |     10.9%        13.3%        20.0%        6.8%        |35.1%        24.8%        35.2%        35.0%        | 
|TERMINAL (d)       |     4/40 (10%)   6/41 (15%)   9/36 (25%)   3/34 (9%)   |13/37 (35%)  6/28 (21%)   13/35 (37%)  15/36 (42%)  | 
|FIRST INCIDENCE    |     421          733 (T)      733 (T)      733 (T)     |616          532          672          674          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.288N     P=0.516      P=0.143      P=0.435N    |P=0.477      P=0.416N     P=0.527      P=0.562      | 
|POLY 3             |     P=0.214N     P=0.484      P=0.179      P=0.379N    |P=0.376      P=0.201N     P=0.581      P=0.585N     | 
|POLY 1.5           |     P=0.203N     P=0.487      P=0.186      P=0.369N    |P=0.368      P=0.187N     P=0.582      P=0.581N     | 
|POLY 6             |     P=0.231N     P=0.486      P=0.170      P=0.393N    |P=0.394      P=0.220N     P=0.581      P=0.583N     | 
|LOGISTIC REGRESSION|     P=0.209N     P=0.498      P=0.193      P=0.354N    |P=0.407      P=0.192N     P=0.575N     P=0.554N     | 
|COCH-ARM / FISHERS |     P=0.195N     P=0.500      P=0.194      P=0.357N    |P=0.370      P=0.168N     P=0.558N     P=0.558N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    19/50 (38%) |0/49 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.23      1/45.08      3/45.68      19/44.99    |0/44.80      0/42.57      1/45.02      1/45.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         6.6%         42.2%       |0.0%         0.0%         2.2%         2.2%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    1/36 (3%)    15/34 (44%) |0/37 (0%)    0/28 (0%)    1/35 (3%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          718          623          530         |---          ---          735 (T)      714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.510      P=0.115      P<0.001 **  |P=0.376      (e)          P=0.489      P=0.515      | 
|POLY 3             |     P<0.001 **   P=0.499      P=0.120      P<0.001 **  |P=0.361      (e)          P=0.501      P=0.503      | 
|POLY 1.5           |     P<0.001 **   P=0.499      P=0.120      P<0.001 **  |P=0.355      (e)          P=0.500      P=0.502      | 
|POLY 6             |     P<0.001 **   P=0.501      P=0.120      P<0.001 **  |P=0.371      (e)          P=0.502      P=0.506      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.499      P=0.115      P<0.001 **  |P=0.362      (e)          P=0.489      P=0.503      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.121      P<0.001 **  |P=0.351      (e)          P=0.505      P=0.505      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Syncytial Alteration                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/50 (52%)  28/50 (56%)  36/50 (72%)  44/50 (88%) |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     26/47.18     28/47.26     36/47.17     44/48.70    |0/44.80      0/42.57      0/45.02      0/45.46      | 
|POLY-3 PERCENT (g) |     55.1%        59.2%        76.3%        90.4%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     22/40 (55%)  24/41 (59%)  28/36 (78%)  33/34 (97%) |0/37 (0%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     384          203          468          467         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.463      P=0.015 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.421      P=0.021 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.422      P=0.024 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.422      P=0.018 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.415      P=0.030 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.421      P=0.032 *    P<0.001 **  |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   0/50 (0%)    1/50 (2%)   |0/49 (0%)    3/50 (6%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/45.23      5/45.71      0/45.00      1/44.17     |0/44.80      3/42.57      0/45.02      4/46.12      | 
|POLY-3 PERCENT (g) |     4.4%         10.9%        0.0%         2.3%        |0.0%         7.1%         0.0%         8.7%         | 
|TERMINAL (d)       |     2/40 (5%)    4/41 (10%)   0/36 (0%)    0/34 (0%)   |0/37 (0%)    3/28 (11%)   0/35 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     733 (T)      495          ---          731         |---          735 (T)      ---          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.243N     P=0.230      P=0.262N     P=0.553N    |P=0.095      P=0.076      (e)          P=0.073      | 
|POLY 3             |     P=0.201N     P=0.220      P=0.238N     P=0.508N    |P=0.072      P=0.110      (e)          P=0.064      | 
|POLY 1.5           |     P=0.198N     P=0.217      P=0.237N     P=0.504N    |P=0.071      P=0.115      (e)          P=0.063      | 
|POLY 6             |     P=0.204N     P=0.225      P=0.241N     P=0.515N    |P=0.075      P=0.103      (e)          P=0.067      | 
|LOGISTIC REGRESSION|     P=0.199N     P=0.216      (e)          P=0.529N    |P=0.075      P=0.076      (e)          P=0.067      | 
|COCH-ARM / FISHERS |     P=0.198N     P=0.218      P=0.247N     P=0.500N    |P=0.073      P=0.125      (e)          P=0.061      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    4/50 (8%)    36/50 (72%) |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.23      0/45.02      4/45.29      36/47.11    |0/44.80      0/42.57      0/45.02      0/45.46      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         8.8%         76.4%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/40 (5%)    0/41 (0%)    3/36 (8%)    28/34 (82%) |0/37 (0%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          654          467         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.233N     P=0.299      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.238N     P=0.338      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.239N     P=0.339      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.237N     P=0.335      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.332      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.247N     P=0.339      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    4/50 (8%)    2/50 (4%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.23      0/45.02      4/46.44      2/44.61     |0/44.80      1/42.59      0/45.02      2/46.58      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         8.6%         4.5%        |0.0%         2.4%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    1/34 (3%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          448          602         |---          731          ---          432          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.233      (e)          P=0.067      P=0.220     |P=0.162      P=0.458      (e)          P=0.245      | 
|POLY 3             |     P=0.240      (e)          P=0.064      P=0.234     |P=0.159      P=0.490      (e)          P=0.246      | 
|POLY 1.5           |     P=0.245      (e)          P=0.063      P=0.236     |P=0.157      P=0.496      (e)          P=0.243      | 
|POLY 6             |     P=0.232      (e)          P=0.064      P=0.231     |P=0.163      P=0.482      (e)          P=0.251      | 
|LOGISTIC REGRESSION|     P=0.225      (e)          P=0.044 *    P=0.237     |P=0.148      P=0.472      (e)          P=0.318      | 
|COCH-ARM / FISHERS |     P=0.248      (e)          P=0.059      P=0.247     |P=0.154      P=0.505      (e)          P=0.253      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/45.23      0/45.02      2/45.00      1/44.74     |0/44.80      0/42.57      3/45.02      0/45.46      | 
|POLY-3 PERCENT (g) |     6.6%         0.0%         4.4%         2.2%        |0.0%         0.0%         6.7%         0.0%         | 
|TERMINAL (d)       |     3/40 (8%)    0/41 (0%)    2/36 (6%)    0/34 (0%)   |0/37 (0%)    0/28 (0%)    3/35 (9%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          733 (T)      552         |---          ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.515N     P=0.117N     P=0.548N     P=0.351N    |P=0.557N     (e)          P=0.111      (e)          | 
|POLY 3             |     P=0.464N     P=0.119N     P=0.502N     P=0.309N    |P=0.567N     (e)          P=0.119      (e)          | 
|POLY 1.5           |     P=0.460N     P=0.120N     P=0.500N     P=0.307N    |P=0.575N     (e)          P=0.119      (e)          | 
|POLY 6             |     P=0.471N     P=0.118N     P=0.507N     P=0.314N    |P=0.554N     (e)          P=0.120      (e)          | 
|LOGISTIC REGRESSION|     P=0.462N     (e)          P=0.548N     P=0.303N    |(e)          (e)          P=0.111      (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.121N     P=0.500N     P=0.309N    |P=0.578N     (e)          P=0.125      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    2/50 (4%)    6/50 (12%)  |4/49 (8%)    2/50 (4%)    3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     5/45.54      2/45.02      2/45.00      6/44.61     |4/45.21      2/42.57      3/45.02      4/45.46      | 
|POLY-3 PERCENT (g) |     11.0%        4.4%         4.4%         13.5%       |8.9%         4.7%         6.7%         8.8%         | 
|TERMINAL (d)       |     4/40 (10%)   2/41 (5%)    2/36 (6%)    5/34 (15%)  |3/37 (8%)    2/28 (7%)    3/35 (9%)    4/36 (11%)   | 
|FIRST INCIDENCE    |     649          733 (T)      733 (T)      602         |616          735 (T)      735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123      P=0.210N     P=0.257N     P=0.401     |P=0.484      P=0.454N     P=0.526N     P=0.633      | 
|POLY 3             |     P=0.179      P=0.221N     P=0.221N     P=0.486     |P=0.458      P=0.365N     P=0.502N     P=0.640N     | 
|POLY 1.5           |     P=0.184      P=0.221N     P=0.218N     P=0.494     |P=0.448      P=0.350N     P=0.502N     P=0.640N     | 
|POLY 6             |     P=0.172      P=0.220N     P=0.227N     P=0.472     |P=0.474      P=0.386N     P=0.503N     P=0.638N     | 
|LOGISTIC REGRESSION|     P=0.172      P=0.217N     P=0.220N     P=0.487     |P=0.473      P=0.359N     P=0.497N     P=0.635N     | 
|COCH-ARM / FISHERS |     P=0.186      P=0.218N     P=0.218N     P=0.500     |P=0.439      P=0.329N     P=0.489N     P=0.631N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |3/49 (6%)    0/50 (0%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/45.23      2/45.02      0/45.00      0/44.16     |3/44.80      0/42.57      1/45.16      3/45.46      | 
|POLY-3 PERCENT (g) |     2.2%         4.4%         0.0%         0.0%        |6.7%         0.0%         2.2%         6.6%         | 
|TERMINAL (d)       |     1/40 (3%)    2/41 (5%)    0/36 (0%)    0/34 (0%)   |3/37 (8%)    0/28 (0%)    0/35 (0%)    3/36 (8%)    | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          ---         |735 (T)      ---          700          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.272N     P=0.509      P=0.521N     P=0.532N    |P=0.326      P=0.174N     P=0.319N     P=0.651      | 
|POLY 3             |     P=0.243N     P=0.498      P=0.501N     P=0.505N    |P=0.311      P=0.128N     P=0.302N     P=0.656N     | 
|POLY 1.5           |     P=0.242N     P=0.498      P=0.500N     P=0.502N    |P=0.302      P=0.123N     P=0.304N     P=0.657N     | 
|POLY 6             |     P=0.245N     P=0.501      P=0.503N     P=0.509N    |P=0.325      P=0.135N     P=0.299N     P=0.651N     | 
|LOGISTIC REGRESSION|     P=0.272N     P=0.509      (e)          (e)         |P=0.323      (e)          P=0.301N     P=0.651      | 
|COCH-ARM / FISHERS |     P=0.240N     P=0.500      P=0.500N     P=0.500N    |P=0.292      P=0.117N     P=0.301N     P=0.651N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/48 (0%)    0/50 (0%)    0/47 (0%)   |0/47 (0%)    1/47 (2%)    2/50 (4%)    2/47 (4%)    | 
|POLY-3 RATE (b)    |     2/44.99      0/43.08      0/45.00      0/42.05     |0/43.26      1/40.27      2/45.26      2/43.36      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |0.0%         2.5%         4.4%         4.6%         | 
|TERMINAL (d)       |     1/40 (3%)    0/40 (0%)    0/36 (0%)    0/34 (0%)   |0/36 (0%)    1/27 (4%)    1/35 (3%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     606          ---          ---          ---         |---          735 (T)      672          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.326N     P=0.247N     P=0.256N     P=0.265N    |P=0.298      P=0.443      P=0.242      P=0.232      | 
|POLY 3             |     P=0.309N     P=0.247N     P=0.237N     P=0.252N    |P=0.273      P=0.486      P=0.247      P=0.238      | 
|POLY 1.5           |     P=0.310N     P=0.246N     P=0.234N     P=0.249N    |P=0.268      P=0.492      P=0.247      P=0.236      | 
|POLY 6             |     P=0.309N     P=0.248N     P=0.242N     P=0.257N    |P=0.281      P=0.478      P=0.248      P=0.240      | 
|LOGISTIC REGRESSION|     P=0.317N     P=0.233N     P=0.237N     P=0.247N    |P=0.279      P=0.443      P=0.250      P=0.232      | 
|COCH-ARM / FISHERS |     P=0.314N     P=0.253N     P=0.242N     P=0.258N    |P=0.263      P=0.500      P=0.263      P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/48 (0%)    0/50 (0%)    1/47 (2%)   |0/47 (0%)    0/47 (0%)    0/50 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     2/44.56      0/43.08      0/45.00      1/42.79     |0/43.26      0/40.27      0/45.02      0/43.36      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         2.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/40 (5%)    0/40 (0%)    0/36 (0%)    0/34 (0%)   |0/36 (0%)    0/27 (0%)    0/35 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          ---          467         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.679      P=0.238N     P=0.262N     P=0.533N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.696      P=0.245N     P=0.235N     P=0.514N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.696      P=0.244N     P=0.233N     P=0.513N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.695      P=0.244N     P=0.238N     P=0.517N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.680      (e)          (e)          P=0.525N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.693      P=0.253N     P=0.242N     P=0.516N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/48 (4%)    1/50 (2%)    2/47 (4%)   |1/47 (2%)    1/47 (2%)    0/50 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     0/44.56      2/43.08      1/45.00      2/42.05     |1/43.26      1/40.27      0/45.02      0/43.36      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         2.2%         4.8%        |2.3%         2.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    2/40 (5%)    1/36 (3%)    2/34 (6%)   |1/36 (3%)    1/27 (4%)    0/35 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      733 (T)     |735 (T)      735 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.286      P=0.238      P=0.479      P=0.203     |P=0.333N     P=0.697      P=0.506N     P=0.506N     | 
|POLY 3             |     P=0.322      P=0.230      P=0.502      P=0.224     |P=0.347N     P=0.745      P=0.492N     P=0.500N     | 
|POLY 1.5           |     P=0.326      P=0.230      P=0.504      P=0.226     |P=0.348N     P=0.751      P=0.492N     P=0.501N     | 
|POLY 6             |     P=0.317      P=0.230      P=0.499      P=0.221     |P=0.345N     P=0.736      P=0.492N     P=0.497N     | 
|LOGISTIC REGRESSION|     (e)          P=0.238      P=0.479      P=0.203     |P=0.333N     P=0.697      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.327      P=0.242      P=0.505      P=0.237     |P=0.349N     P=0.753N     P=0.485N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/0 (0%)     0/3 (0%)     0/1 (0%)    |2/5 (40%)    0/2 (0%)     0/4 (0%)     0/1 (0%)     | 
|POLY-3 RATE (b)    |     0/0.65       0/0.00       0/2.43       0/0.43      |2/4.12       0/1.50       0/3.44       0/0.65       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |48.5%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/1 (0%)     0/0 (0%)    |0/2 (0%)     0/0 (0%)     0/2 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |599          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.301N     P=0.276N     P=0.246N     P=0.243N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.460N     P=0.476N     P=0.240N     P=0.690N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.499N     P=0.454N     P=0.239N     P=0.656N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.355N     P=0.522N     P=0.263N     P=0.748N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.524N     P=0.438N     P=0.259N     P=0.652N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.524N     P=0.476N     P=0.278N     P=0.667N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     0/1 (0%)     0/1 (0%)    |2/48 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/0.00       0/0.00       0/1.00       0/1.00      |2/43.88      1/43.06      1/45.03      0/45.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         2.3%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/1 (0%)     0/1 (0%)    |2/37 (5%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      588          734          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.204N     P=0.569N     P=0.516N     P=0.244N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.204N     P=0.507N     P=0.491N     P=0.229N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.207N     P=0.498N     P=0.492N     P=0.230N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.198N     P=0.517N     P=0.490N     P=0.227N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.210N     P=0.472N     P=0.503N     (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.210N     P=0.485N     P=0.485N     P=0.237N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/14 (21%)   1/11 (9%)    2/10 (20%)   3/15 (20%)  |2/17 (12%)   0/18 (0%)    0/12 (0%)    2/18 (11%)   | 
|POLY-3 RATE (b)    |     3/12.72      1/9.69       2/9.87       3/14.17     |2/16.38      0/16.36      0/11.33      2/17.37      | 
|POLY-3 PERCENT (g) |     23.6%        10.3%        20.3%        21.2%       |12.2%        0.0%         0.0%         11.5%        | 
|TERMINAL (d)       |     3/11 (27%)   1/9 (11%)    2/9 (22%)    3/11 (27%)  |1/14 (7%)    0/12 (0%)    0/10 (0%)    2/14 (14%)   | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |659          ---          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.471      P=0.371N     P=0.600N     P=0.680     |P=0.380      P=0.271N     P=0.276N     P=0.694N     | 
|POLY 3             |     P=0.557      P=0.401N     P=0.622N     P=0.619N    |P=0.389      P=0.232N     P=0.319N     P=0.676N     | 
|POLY 1.5           |     P=0.547      P=0.398N     P=0.637N     P=0.627N    |P=0.383      P=0.227N     P=0.318N     P=0.676N     | 
|POLY 6             |     P=0.566      P=0.401N     P=0.605N     P=0.610N    |P=0.397      P=0.241N     P=0.319N     P=0.679N     | 
|LOGISTIC REGRESSION|     P=0.471      P=0.371N     P=0.600N     P=0.680     |P=0.369      P=0.201N     P=0.297N     P=0.697N     | 
|COCH-ARM / FISHERS |     P=0.530      P=0.396N     P=0.668N     P=0.639N    |P=0.372      P=0.229N     P=0.335N     P=0.677N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/14 (86%)  9/11 (82%)   9/10 (90%)   12/15 (80%) |16/17 (94%)  16/18 (89%)  11/12 (92%)  16/18 (89%)  | 
|POLY-3 RATE (b)    |     12/14.00     9/10.38      9/10.00      12/14.80    |16/16.72     16/17.35     11/12.00     16/18.00     | 
|POLY-3 PERCENT (g) |     85.7%        86.7%        90.0%        81.1%       |95.7%        92.2%        91.7%        88.9%        | 
|TERMINAL (d)       |     9/11 (82%)   8/9 (89%)    8/9 (89%)    10/11 (91%) |14/14 (100%) 12/12 (100%) 9/10 (90%)   12/14 (86%)  | 
|FIRST INCIDENCE    |     476          495          700          530         |568          588          511          624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.468      P=0.450N     P=0.461N     P=0.623     |P=0.454N     P=0.293      P=0.477N     P=0.625N     | 
|POLY 3             |     P=0.448N     P=0.697      P=0.618      P=0.565N    |P=0.407N     P=0.626N     P=0.640N     P=0.454N     | 
|POLY 1.5           |     P=0.452N     P=0.692N     P=0.618      P=0.549N    |P=0.455N     P=0.583N     P=0.661N     P=0.486N     | 
|POLY 6             |     P=0.461N     P=0.650      P=0.618      P=0.594N    |P=0.344N     P=0.662N     P=0.599N     P=0.401N     | 
|LOGISTIC REGRESSION|     P=0.451N     P=0.626N     (e)          P=0.555N    |P=0.444N     P=0.656N     P=0.703N     P=0.493N     | 
|COCH-ARM / FISHERS |     P=0.467N     P=0.604N     P=0.629      P=0.535N    |P=0.517N     P=0.522N     P=0.665N     P=0.522N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    4/50 (8%)    2/48 (4%)   |3/49 (6%)    1/50 (2%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/45.66      2/45.99      4/45.73      2/43.27     |3/44.80      1/42.58      0/45.02      1/44.56      | 
|POLY-3 PERCENT (g) |     2.2%         4.4%         8.8%         4.6%        |6.7%         2.4%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/40 (0%)    1/41 (2%)    1/36 (3%)    1/34 (3%)   |3/37 (8%)    0/28 (0%)    0/35 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     606          203          612          552         |735 (T)      733          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527      P=0.495      P=0.171      P=0.474     |P=0.382N     P=0.406N     P=0.131N     P=0.315N     | 
|POLY 3             |     P=0.539      P=0.503      P=0.179      P=0.481     |P=0.399N     P=0.324N     P=0.118N     P=0.307N     | 
|POLY 1.5           |     P=0.544      P=0.502      P=0.180      P=0.484     |P=0.405N     P=0.313N     P=0.118N     P=0.309N     | 
|POLY 6             |     P=0.529      P=0.503      P=0.177      P=0.476     |P=0.390N     P=0.337N     P=0.117N     P=0.302N     | 
|LOGISTIC REGRESSION|     P=0.508      P=0.600      P=0.170      P=0.469     |P=0.382N     P=0.373N     (e)          P=0.315N     | 
|COCH-ARM / FISHERS |     P=0.549      P=0.500      P=0.181      P=0.485     |P=0.412N     P=0.301N     P=0.117N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/48 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/45.23      2/45.99      0/45.00      0/42.69     |0/44.80      0/42.57      0/45.02      0/44.56      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    1/41 (2%)    0/36 (0%)    0/34 (0%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          203          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.408N     P=0.242      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.398N     P=0.241      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.397N     P=0.240      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.398N     P=0.243      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.520N     P=0.311      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.399N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Glands                                                                                                                     | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    3/48 (6%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    5/49 (10%)   | 
|POLY-3 RATE (b)    |     2/45.23      2/45.02      1/45.00      3/42.69     |0/44.80      0/42.57      1/45.02      5/44.56      | 
|POLY-3 PERCENT (g) |     4.4%         4.4%         2.2%         7.0%        |0.0%         0.0%         2.2%         11.2%        | 
|TERMINAL (d)       |     2/40 (5%)    2/41 (5%)    1/36 (3%)    3/34 (9%)   |0/37 (0%)    0/28 (0%)    1/35 (3%)    5/36 (14%)   | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |---          ---          735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292      P=0.686N     P=0.537N     P=0.426     |P=0.002 **   (e)          P=0.489      P=0.031 *    | 
|POLY 3             |     P=0.342      P=0.692      P=0.502N     P=0.474     |P<0.001 **   (e)          P=0.501      P=0.030 *    | 
|POLY 1.5           |     P=0.346      P=0.691      P=0.500N     P=0.478     |P<0.001 **   (e)          P=0.500      P=0.030 *    | 
|POLY 6             |     P=0.335      P=0.693N     P=0.506N     P=0.467     |P<0.001 **   (e)          P=0.502      P=0.031 *    | 
|LOGISTIC REGRESSION|     P=0.292      P=0.686N     P=0.537N     P=0.426     |(e)          (e)          P=0.489      P=0.031 *    | 
|COCH-ARM / FISHERS |     P=0.347      P=0.691N     P=0.500N     P=0.480     |P<0.001 **   (e)          P=0.505      P=0.028 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    0/48 (0%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     1/45.23      1/45.99      3/45.73      0/42.69     |0/44.80      0/42.57      1/45.02      2/44.64      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         6.6%         0.0%        |0.0%         0.0%         2.2%         4.5%         | 
|TERMINAL (d)       |     1/40 (3%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |0/37 (0%)    0/28 (0%)    1/35 (3%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     733 (T)      203          612          ---         |---          ---          735 (T)      714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.330N     P=0.758N     P=0.291      P=0.532N    |P=0.116      (e)          P=0.489      P=0.245      | 
|POLY 3             |     P=0.325N     P=0.757N     P=0.309      P=0.512N    |P=0.099      (e)          P=0.501      P=0.236      | 
|POLY 1.5           |     P=0.320N     P=0.758N     P=0.309      P=0.510N    |P=0.096      (e)          P=0.500      P=0.235      | 
|POLY 6             |     P=0.333N     P=0.755N     P=0.309      P=0.515N    |P=0.104      (e)          P=0.502      P=0.239      | 
|LOGISTIC REGRESSION|     P=0.362N     P=0.689N     P=0.301      (e)         |P=0.106      (e)          P=0.489      P=0.238      | 
|COCH-ARM / FISHERS |     P=0.315N     P=0.753N     P=0.309      P=0.510N    |P=0.095      (e)          P=0.505      P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/49 (0%)    2/49 (4%)    1/49 (2%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |                                                        |0/44.80      2/41.74      1/44.32      1/44.44      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         4.8%         2.3%         2.3%         | 
|TERMINAL (d)       |                                                        |0/37 (0%)    1/27 (4%)    1/35 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          692          735 (T)      686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.675      P=0.195      P=0.489      P=0.514      | 
|POLY 3             |                                                        |P=0.653      P=0.222      P=0.498      P=0.498      | 
|POLY 1.5           |                                                        |P=0.649      P=0.228      P=0.497      P=0.496      | 
|POLY 6             |                                                        |P=0.659      P=0.214      P=0.500      P=0.502      | 
|LOGISTIC REGRESSION|                                                        |P=0.654      P=0.221      P=0.489      P=0.499      | 
|COCH-ARM / FISHERS |                                                        |P=0.648      P=0.247      P=0.500      P=0.495      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |16/49 (33%)  11/49 (22%)  8/49 (16%)   10/48 (21%)  | 
|POLY-3 RATE (b)    |                                                        |16/45.83     11/42.77     8/44.67      10/44.29     | 
|POLY-3 PERCENT (g) |                                                        |34.9%        25.7%        17.9%        22.6%        | 
|TERMINAL (d)       |                                                        |12/37 (32%)  7/27 (26%)   6/35 (17%)   9/35 (26%)   | 
|FIRST INCIDENCE    |                                                        |568          601          652          727          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.183N     P=0.448N     P=0.070N     P=0.157N     | 
|POLY 3             |                                                        |P=0.229N     P=0.238N     P=0.053N     P=0.144N     | 
|POLY 1.5           |                                                        |P=0.240N     P=0.215N     P=0.054N     P=0.144N     | 
|POLY 6             |                                                        |P=0.215N     P=0.271N     P=0.052N     P=0.142N     | 
|LOGISTIC REGRESSION|                                                        |P=0.216N     P=0.229N     P=0.053N     P=0.129N     | 
|COCH-ARM / FISHERS |                                                        |P=0.254N     P=0.183N     P=0.049N*    P=0.139N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/50 (2%)    3/50 (6%)    3/49 (6%)   |20/49 (41%)  20/49 (41%)  20/49 (41%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |     2/43.48      1/45.57      3/45.00      3/43.63     |20/46.77     20/43.53     20/44.85     12/45.73     | 
|POLY-3 PERCENT (g) |     4.6%         2.2%         6.7%         6.9%        |42.8%        45.9%        44.6%        26.2%        | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    3/36 (8%)    3/34 (9%)   |15/37 (41%)  15/28 (54%)  15/34 (44%)  10/36 (28%)  | 
|FIRST INCIDENCE    |     665          561          733 (T)      733 (T)     |363          588          652          686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.285      P=0.496N     P=0.478      P=0.453     |P=0.017N*    P=0.238      P=0.483      P=0.081N     | 
|POLY 3             |     P=0.329      P=0.484N     P=0.516      P=0.502     |P=0.025N*    P=0.463      P=0.513      P=0.071N     | 
|POLY 1.5           |     P=0.336      P=0.486N     P=0.518      P=0.506     |P=0.026N*    P=0.508      P=0.522      P=0.068N     | 
|POLY 6             |     P=0.316      P=0.480N     P=0.509      P=0.493     |P=0.021N*    P=0.412      P=0.513      P=0.070N     | 
|LOGISTIC REGRESSION|     P=0.338      P=0.471N     P=0.517      P=0.502     |P=0.022N*    P=0.533      P=0.558      P=0.059N     | 
|COCH-ARM / FISHERS |     P=0.339      P=0.485N     P=0.520      P=0.510     |P=0.026N*    P=0.581N     P=0.581N     P=0.057N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |2/49 (4%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.23      0/45.02      0/45.00      0/43.63     |2/45.49      0/42.28      0/44.02      0/45.46      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |0/37 (0%)    0/28 (0%)    0/34 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          ---          ---         |616          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.571N     P=0.485N     P=0.511N     P=0.522N    |P=0.296N     P=0.264N     P=0.240N     P=0.232N     | 
|POLY 3             |     P=0.547N     P=0.492N     P=0.492N     P=0.498N    |P=0.290N     P=0.254N     P=0.245N     P=0.237N     | 
|POLY 1.5           |     P=0.547N     P=0.493N     P=0.491N     P=0.497N    |P=0.295N     P=0.247N     P=0.243N     P=0.237N     | 
|POLY 6             |     P=0.548N     P=0.490N     P=0.494N     P=0.501N    |P=0.281N     P=0.264N     P=0.246N     P=0.237N     | 
|LOGISTIC REGRESSION|     P=0.571N     (e)          (e)          (e)         |P=0.301N     P=0.201N     P=0.202N     P=0.201N     | 
|COCH-ARM / FISHERS |     P=0.547N     P=0.490N     P=0.490N     P=0.495N    |P=0.305N     P=0.247N     P=0.247N     P=0.242N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/49 (57%)  24/49 (49%)  21/50 (42%)  22/50 (44%) |                                                    | 
|POLY-3 RATE (b)    |     28/46.50     24/47.27     21/47.14     22/47.01    |                                                    | 
|POLY-3 PERCENT (g) |     60.2%        50.8%        44.5%        46.8%       |                                                    | 
|TERMINAL (d)       |     23/40 (58%)  19/41 (46%)  15/36 (42%)  14/34 (41%) |                                                    | 
|FIRST INCIDENCE    |     421          497          468          467         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.496N     P=0.263N     P=0.236N     P=0.382N    |                                                    | 
|POLY 3             |     P=0.220N     P=0.238N     P=0.092N     P=0.134N    |                                                    | 
|POLY 1.5           |     P=0.205N     P=0.257N     P=0.090N     P=0.129N    |                                                    | 
|POLY 6             |     P=0.253N     P=0.218N     P=0.099N     P=0.150N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.204N     P=0.274N     P=0.096N     P=0.137N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.203N     P=0.272N     P=0.096N     P=0.134N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    2/50 (4%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/44.58      1/44.53      2/45.00      2/44.16     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         4.4%         4.5%        |                                                    | 
|TERMINAL (d)       |     1/40 (3%)    1/41 (2%)    2/36 (6%)    2/34 (6%)   |                                                    | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.343      P=0.756N     P=0.463      P=0.443     |                                                    | 
|POLY 3             |     P=0.405      P=0.760      P=0.503      P=0.497     |                                                    | 
|POLY 1.5           |     P=0.413      P=0.759      P=0.506      P=0.502     |                                                    | 
|POLY 6             |     P=0.391      P=0.759N     P=0.498      P=0.488     |                                                    | 
|LOGISTIC REGRESSION|     P=0.343      P=0.756N     P=0.463      P=0.443     |                                                    | 
|COCH-ARM / FISHERS |     P=0.417      P=0.753N     P=0.508      P=0.508     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/43.56      2/45.02      0/45.00      0/44.16     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/39 (0%)    2/41 (5%)    0/36 (0%)    0/34 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.422N     P=0.249      (e)          (e)         |                                                    | 
|POLY 3             |     P=0.390N     P=0.244      (e)          (e)         |                                                    | 
|POLY 1.5           |     P=0.388N     P=0.244      (e)          (e)         |                                                    | 
|POLY 6             |     P=0.392N     P=0.245      (e)          (e)         |                                                    | 
|LOGISTIC REGRESSION|     (e)          P=0.249      (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.386N     P=0.258      (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/43.56      0/45.02      2/45.20      0/44.16     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/39 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          700          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.668N     (e)          P=0.234      (e)         |                                                    | 
|POLY 3             |     P=0.656N     (e)          P=0.245      (e)         |                                                    | 
|POLY 1.5           |     P=0.650N     (e)          P=0.247      (e)         |                                                    | 
|POLY 6             |     P=0.664N     (e)          P=0.243      (e)         |                                                    | 
|LOGISTIC REGRESSION|     P=0.649N     (e)          P=0.246      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.647N     (e)          P=0.258      (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/49 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.23      0/45.02      0/45.00      1/44.16     |1/44.80      2/43.03      1/45.02      1/45.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |2.2%         4.7%         2.2%         2.2%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    1/34 (3%)   |1/37 (3%)    1/28 (4%)    1/35 (3%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |735 (T)      601          735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.202      (e)          (e)          P=0.468     |P=0.521N     P=0.428      P=0.749      P=0.756      | 
|POLY 3             |     P=0.225      (e)          (e)          P=0.495     |P=0.543N     P=0.486      P=0.760N     P=0.757N     | 
|POLY 1.5           |     P=0.227      (e)          (e)          P=0.498     |P=0.545N     P=0.494      P=0.760N     P=0.758N     | 
|POLY 6             |     P=0.221      (e)          (e)          P=0.491     |P=0.539N     P=0.475      P=0.759N     P=0.755N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.468     |P=0.543N     P=0.516      P=0.749      P=0.756      | 
|COCH-ARM / FISHERS |     P=0.228      (e)          (e)          P=0.500     |P=0.546N     P=0.508      P=0.747N     P=0.747N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    4/50 (8%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.54      2/46.15      2/45.20      4/45.14     |0/44.80      0/42.57      0/45.02      1/45.46      | 
|POLY-3 PERCENT (g) |     2.2%         4.3%         4.4%         8.9%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    2/34 (6%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     649          532          700          552         |---          ---          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.120      P=0.492      P=0.491      P=0.158     |P=0.243      (e)          (e)          P=0.495      | 
|POLY 3             |     P=0.130      P=0.505      P=0.497      P=0.176     |P=0.234      (e)          (e)          P=0.503      | 
|POLY 1.5           |     P=0.133      P=0.501      P=0.500      P=0.178     |P=0.231      (e)          (e)          P=0.502      | 
|POLY 6             |     P=0.125      P=0.509      P=0.493      P=0.172     |P=0.239      (e)          (e)          P=0.505      | 
|LOGISTIC REGRESSION|     P=0.121      P=0.557      P=0.498      P=0.176     |(e)          (e)          (e)          P=0.495      | 
|COCH-ARM / FISHERS |     P=0.134      P=0.500      P=0.500      P=0.181     |P=0.229      (e)          (e)          P=0.505      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    2/50 (4%)    2/49 (4%)   |1/49 (2%)    2/47 (4%)    2/50 (4%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     1/44.56      1/45.02      2/45.00      2/43.69     |1/44.80      2/41.01      2/45.91      3/44.39      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         4.4%         4.6%        |2.2%         4.9%         4.4%         6.8%         | 
|TERMINAL (d)       |     1/40 (3%)    1/41 (2%)    2/36 (6%)    1/34 (3%)   |1/37 (3%)    1/28 (4%)    1/35 (3%)    2/36 (6%)    | 
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      718         |735 (T)      728          356          727          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.351      P=0.756N     P=0.463      P=0.457     |P=0.317      P=0.415      P=0.487      P=0.299      | 
|POLY 3             |     P=0.399      P=0.758N     P=0.503      P=0.493     |P=0.294      P=0.469      P=0.509      P=0.302      | 
|POLY 1.5           |     P=0.404      P=0.758N     P=0.506      P=0.497     |P=0.288      P=0.476      P=0.506      P=0.299      | 
|POLY 6             |     P=0.390      P=0.758N     P=0.498      P=0.487     |P=0.304      P=0.460      P=0.511      P=0.308      | 
|LOGISTIC REGRESSION|     P=0.380      P=0.756N     P=0.463      P=0.481     |P=0.278      P=0.443      P=0.578      P=0.312      | 
|COCH-ARM / FISHERS |     P=0.405      P=0.747N     P=0.508      P=0.500     |P=0.282      P=0.484      P=0.508      P=0.301      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)   |1/49 (2%)    2/47 (4%)    0/50 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     0/44.56      0/45.02      0/45.00      1/43.67     |1/44.80      2/41.43      0/45.02      1/44.36      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |2.2%         4.8%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |1/37 (3%)    1/28 (4%)    0/35 (0%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          723         |735 (T)      601          ---          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.216      (e)          (e)          P=0.484     |P=0.568N     P=0.428      P=0.511N     P=0.756      | 
|POLY 3             |     P=0.223      (e)          (e)          P=0.496     |P=0.593N     P=0.473      P=0.499N     P=0.758      | 
|POLY 1.5           |     P=0.225      (e)          (e)          P=0.498     |P=0.595N     P=0.478      P=0.500N     P=0.756      | 
|POLY 6             |     P=0.220      (e)          (e)          P=0.492     |P=0.590N     P=0.466      P=0.498N     P=0.759N     | 
|LOGISTIC REGRESSION|     P=0.220      (e)          (e)          P=0.493     |P=0.596N     P=0.495      (e)          P=0.756      | 
|COCH-ARM / FISHERS |     P=0.225      (e)          (e)          P=0.500     |P=0.597N     P=0.484      P=0.495N     P=0.747      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    4/50 (8%)    1/49 (2%)    9/50 (18%)  |5/49 (10%)   1/49 (2%)    6/50 (12%)   2/47 (4%)    | 
|POLY-3 RATE (b)    |     4/44.99      4/46.55      1/44.55      9/44.95     |5/45.91      1/42.28      6/45.63      2/44.34      | 
|POLY-3 PERCENT (g) |     8.9%         8.6%         2.2%         20.0%       |10.9%        2.4%         13.2%        4.5%         | 
|TERMINAL (d)       |     3/40 (8%)    2/41 (5%)    1/36 (3%)    5/34 (15%)  |3/37 (8%)    1/28 (4%)    4/35 (11%)   1/36 (3%)    | 
|FIRST INCIDENCE    |     606          203          733 (T)      622         |363          735 (T)      612          309          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.014 *    P=0.639N     P=0.211N     P=0.081     |P=0.289N     P=0.160N     P=0.482      P=0.226N     | 
|POLY 3             |     P=0.021 *    P=0.624N     P=0.181N     P=0.114     |P=0.309N     P=0.121N     P=0.496      P=0.230N     | 
|POLY 1.5           |     P=0.022 *    P=0.626N     P=0.179N     P=0.119     |P=0.325N     P=0.113N     P=0.495      P=0.233N     | 
|POLY 6             |     P=0.019 *    P=0.622N     P=0.186N     P=0.106     |P=0.287N     P=0.132N     P=0.500      P=0.225N     | 
|LOGISTIC REGRESSION|     P=0.024 *    P=0.594N     P=0.179N     P=0.121     |P=0.356N     P=0.079N     P=0.540      P=0.172N     | 
|COCH-ARM / FISHERS |     P=0.025 *    P=0.631N     P=0.181N     P=0.125     |P=0.348N     P=0.102N     P=0.514      P=0.235N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Acute                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    1/50 (2%)    1/49 (2%)    4/50 (8%)   |1/49 (2%)    0/49 (0%)    1/50 (2%)    2/47 (4%)    | 
|POLY-3 RATE (b)    |     2/45.37      1/45.99      1/44.55      4/44.63     |1/44.80      0/42.28      1/45.02      2/44.52      | 
|POLY-3 PERCENT (g) |     4.4%         2.2%         2.2%         9.0%        |2.2%         0.0%         2.2%         4.5%         | 
|TERMINAL (d)       |     1/40 (3%)    0/41 (0%)    1/36 (3%)    1/34 (3%)   |1/37 (3%)    0/28 (0%)    1/35 (3%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     421          203          733 (T)      622         |735 (T)      ---          735 (T)      309          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.100      P=0.497N     P=0.522N     P=0.302     |P=0.262      P=0.556N     P=0.749      P=0.507      | 
|POLY 3             |     P=0.114      P=0.495N     P=0.506N     P=0.330     |P=0.245      P=0.512N     P=0.760N     P=0.498      | 
|POLY 1.5           |     P=0.117      P=0.494N     P=0.503N     P=0.337     |P=0.236      P=0.507N     P=0.760N     P=0.492      | 
|POLY 6             |     P=0.110      P=0.495N     P=0.511N     P=0.320     |P=0.258      P=0.518N     P=0.759N     P=0.506      | 
|LOGISTIC REGRESSION|     P=0.095      P=0.372N     P=0.540N     P=0.347     |P=0.212      (e)          P=0.749      P=0.565      | 
|COCH-ARM / FISHERS |     P=0.121      P=0.492N     P=0.500N     P=0.349     |P=0.224      P=0.500N     P=0.747N     P=0.484      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/49 (0%)    4/50 (8%)   |0/49 (0%)    0/49 (0%)    0/50 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     1/44.86      1/45.71      0/44.55      4/45.30     |0/44.80      0/42.28      0/45.02      0/43.41      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         0.0%         8.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |0/37 (0%)    0/28 (0%)    0/35 (0%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     649          495          ---          530         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    P=0.756N     P=0.505N     P=0.166     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.037 *    P=0.756N     P=0.501N     P=0.182     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.037 *    P=0.757N     P=0.500N     P=0.184     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.036 *    P=0.756N     P=0.505N     P=0.177     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.030 *    P=0.721N     P=0.515N     P=0.180     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.038 *    P=0.747N     P=0.500N     P=0.187     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/49 (0%)    1/48 (2%)    0/48 (0%)   |0/48 (0%)    2/47 (4%)    3/50 (6%)    1/47 (2%)    | 
|POLY-3 RATE (b)    |     1/44.56      0/44.62      1/44.71      0/42.69     |0/44.15      2/41.09      3/45.44      1/43.41      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.2%         0.0%        |0.0%         4.9%         6.6%         2.3%         | 
|TERMINAL (d)       |     1/40 (3%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |0/37 (0%)    2/28 (7%)    2/35 (6%)    1/36 (3%)    | 
|FIRST INCIDENCE    |     733 (T)      ---          468          ---         |---          735 (T)      612          735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.495N     P=0.495N     P=0.751      P=0.532N    |P=0.581N     P=0.179      P=0.118      P=0.495      | 
|POLY 3             |     P=0.488N     P=0.500N     P=0.760N     P=0.509N    |P=0.617N     P=0.221      P=0.124      P=0.497      | 
|POLY 1.5           |     P=0.484N     P=0.501N     P=0.760      P=0.506N    |P=0.621N     P=0.226      P=0.123      P=0.495      | 
|POLY 6             |     P=0.494N     P=0.498N     P=0.760N     P=0.513N    |P=0.609N     P=0.215      P=0.125      P=0.499      | 
|LOGISTIC REGRESSION|     P=0.513N     (e)          P=0.720      (e)         |P=0.617N     P=0.179      P=0.129      P=0.495      | 
|COCH-ARM / FISHERS |     P=0.482N     P=0.500N     P=0.747      P=0.505N    |P=0.623N     P=0.242      P=0.129      P=0.495      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    2/48 (4%)    0/48 (0%)   |1/48 (2%)    0/47 (0%)    1/50 (2%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     0/44.56      0/44.62      2/44.11      0/42.69     |1/44.15      0/41.09      1/45.02      0/43.41      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |2.3%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |1/37 (3%)    0/28 (0%)    1/35 (3%)    0/36 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          703          ---         |735 (T)      ---          735 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.676N     (e)          P=0.228      (e)         |P=0.459N     P=0.556N     P=0.749      P=0.505N     | 
|POLY 3             |     P=0.664N     (e)          P=0.235      (e)         |P=0.471N     P=0.514N     P=0.756N     P=0.503N     | 
|POLY 1.5           |     P=0.659N     (e)          P=0.235      (e)         |P=0.476N     P=0.510N     P=0.756N     P=0.505N     | 
|POLY 6             |     P=0.672N     (e)          P=0.234      (e)         |P=0.463N     P=0.520N     P=0.756N     P=0.501N     | 
|LOGISTIC REGRESSION|     P=0.661N     (e)          P=0.234      (e)         |P=0.459N     (e)          P=0.749      (e)          | 
|COCH-ARM / FISHERS |     P=0.656N     (e)          P=0.242      (e)         |P=0.482N     P=0.505N     P=0.742N     P=0.505N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/45.23      0/45.02      0/45.00      0/44.16     |                                                    | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     2/40 (5%)    0/41 (0%)    0/36 (0%)    0/34 (0%)   |                                                    | 
|FIRST INCIDENCE    |     733 (T)      ---          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.338N     P=0.233N     P=0.262N     P=0.275N    |                                                    | 
|POLY 3             |     P=0.308N     P=0.238N     P=0.238N     P=0.242N    |                                                    | 
|POLY 1.5           |     P=0.307N     P=0.239N     P=0.237N     P=0.240N    |                                                    | 
|POLY 6             |     P=0.310N     P=0.237N     P=0.241N     P=0.247N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.338N     (e)          (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.308N     P=0.247N     P=0.247N     P=0.247N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/44 (0%)    1/44 (2%)    0/42 (0%)    0/40 (0%)   |0/48 (0%)    1/48 (2%)    0/48 (0%)    2/47 (4%)    | 
|POLY-3 RATE (b)    |     0/39.23      1/40.67      0/38.84      0/35.25     |0/43.80      1/41.67      0/43.12      2/44.47      | 
|POLY-3 PERCENT (g) |     0.0%         2.5%         0.0%         0.0%        |0.0%         2.4%         0.0%         4.5%         | 
|TERMINAL (d)       |     0/34 (0%)    0/37 (0%)    0/34 (0%)    0/27 (0%)   |0/36 (0%)    0/27 (0%)    0/34 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          495          ---          ---         |---          305          ---          309          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.606N     P=0.504      (e)          (e)         |P=0.169      P=0.504      (e)          P=0.253      | 
|POLY 3             |     P=0.623N     P=0.507      (e)          (e)         |P=0.155      P=0.490      (e)          P=0.240      | 
|POLY 1.5           |     P=0.624N     P=0.503      (e)          (e)         |P=0.152      P=0.495      (e)          P=0.237      | 
|POLY 6             |     P=0.621N     P=0.512      (e)          (e)         |P=0.159      P=0.483      (e)          P=0.246      | 
|LOGISTIC REGRESSION|     P=0.712N     P=0.572      (e)          (e)         |P=0.115      (e)          (e)          P=0.300      | 
|COCH-ARM / FISHERS |     P=0.625N     P=0.500      (e)          (e)         |P=0.148      P=0.500      (e)          P=0.242      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)   |1/49 (2%)    2/49 (4%)    1/50 (2%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     0/43.56      0/43.02      0/44.00      0/43.63     |1/44.80      2/42.39      1/45.69      0/43.26      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         4.7%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    0/28 (0%)    0/35 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      532          511          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.238N     P=0.445      P=0.754      P=0.517N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.245N     P=0.481      P=0.756N     P=0.507N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.247N     P=0.488      P=0.758N     P=0.508N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.242N     P=0.471      P=0.754N     P=0.504N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.247N     P=0.536      P=0.729N     (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.247N     P=0.500      P=0.747N     P=0.510N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     21/23 (91%)  26/26 (100%) 22/22 (100%) 20/21 (95%) |3/4 (75%)    1/2 (50%)    1/1 (100%)   1/1 (100%)   | 
|POLY-3 RATE (b)    |     21/23.00     26/26.00     22/22.00     20/21.00    |3/4.00       1/1.99       1/1.00       1/1.00       | 
|POLY-3 PERCENT (g) |     91.3%        100.0%       100.0%       95.2%       |75.0%        50.2%        100.0%       100.0%       | 
|TERMINAL (d)       |     20/22 (91%)  25/25 (100%) 19/19 (100%) 19/20 (95%) |3/4 (75%)    1/1 (100%)   1/1 (100%)   1/1 (100%)   | 
|FIRST INCIDENCE    |     635          575          596          731         |735 (T)      735 (T)      735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.577N     P=0.283      P=0.114      P=0.507     |P=0.708      P=0.773      P=0.773      P=0.773      | 
|POLY 3             |     P=0.670N     P=0.208      P=0.245      P=0.532     |P=0.574      P=0.604N     P=0.749      P=0.749      | 
|POLY 1.5           |     P=0.670N     P=0.208      P=0.245      P=0.532     |P=0.573      P=0.603N     P=0.749      P=0.749      | 
|POLY 6             |     P=0.670N     P=0.208      P=0.245      P=0.532     |P=0.575      P=0.607N     P=0.749      P=0.749      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.708      P=0.773      P=0.773      P=0.773      | 
|COCH-ARM / FISHERS |     P=0.671N     P=0.215      P=0.256      P=0.535     |P=0.594      P=0.600N     P=0.800      P=0.800      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/49 (2%)    2/49 (4%)    2/50 (4%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.80      2/42.56      2/45.02      3/45.26      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         4.7%         4.4%         6.6%         | 
|TERMINAL (d)       |                                                        |1/37 (3%)    1/28 (4%)    2/35 (6%)    3/36 (8%)    | 
|FIRST INCIDENCE    |                                                        |735 (T)      658          735 (T)      735 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.322      P=0.425      P=0.481      P=0.295      | 
|POLY 3             |                                                        |P=0.297      P=0.482      P=0.502      P=0.309      | 
|POLY 1.5           |                                                        |P=0.291      P=0.489      P=0.501      P=0.306      | 
|POLY 6             |                                                        |P=0.307      P=0.473      P=0.503      P=0.314      | 
|LOGISTIC REGRESSION|                                                        |P=0.312      P=0.489      P=0.481      P=0.295      | 
|COCH-ARM / FISHERS |                                                        |P=0.284      P=0.500      P=0.508      P=0.309      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/11/02                           EXPERIMENT: 93026 TEST: 06                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DECALIN           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/49 (6%)    3/49 (6%)    5/50 (10%)   0/49 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/45.96      3/42.30      5/45.21      0/45.26      | 
|POLY-3 PERCENT (g) |                                                        |6.5%         7.1%         11.1%        0.0%         | 
|TERMINAL (d)       |                                                        |1/37 (3%)    2/28 (7%)    4/35 (11%)   0/36 (0%)    | 
|FIRST INCIDENCE    |                                                        |363          731          686          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.072N     P=0.565      P=0.343      P=0.127N     | 
|POLY 3             |                                                        |P=0.075N     P=0.624      P=0.347      P=0.121N     | 
|POLY 1.5           |                                                        |P=0.078N     P=0.639      P=0.350      P=0.122N     | 
|POLY 6             |                                                        |P=0.070N     P=0.604      P=0.347      P=0.120N     | 
|LOGISTIC REGRESSION|                                                        |P=0.082N     P=0.617N     P=0.394      P=0.077N     | 
|COCH-ARM / FISHERS |                                                        |P=0.081N     P=0.661N     P=0.369      P=0.121N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      25 PPM       100 PPM      400 PPM     |CONTROL      25 PPM       100 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |7/49 (14%)   5/49 (10%)   4/50 (8%)    8/49 (16%)   | 
|POLY-3 RATE (b)    |                                                        |7/44.92      5/42.81      4/45.02      8/45.52      | 
|POLY-3 PERCENT (g) |                                                        |15.6%        11.7%        8.9%         17.6%        | 
|TERMINAL (d)       |                                                        |6/37 (16%)   4/28 (14%)   4/35 (11%)   6/36 (17%)   | 
|FIRST INCIDENCE    |                                                        |703          571          735 (T)      674          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.348      P=0.559N     P=0.290N     P=0.491      | 
|POLY 3             |                                                        |P=0.304      P=0.413N     P=0.259N     P=0.511      | 
|POLY 1.5           |                                                        |P=0.291      P=0.399N     P=0.261N     P=0.503      | 
|POLY 6             |                                                        |P=0.325      P=0.433N     P=0.257N     P=0.526      | 
|LOGISTIC REGRESSION|                                                        |P=0.322      P=0.428N     P=0.253N     P=0.525      | 
|COCH-ARM / FISHERS |                                                        |P=0.279      P=0.380N     P=0.251N     P=0.500      | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
                                                                                                                                   
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.