TDMS Study 93026-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DECALIN DATE: 04/11/02
EXPERIMENT: 93026 TEST: 06 TIME: 09:30:52
TEST TYPE: CHRONIC PAGE: 1
CONT: N01-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C93026
PATHOLOGIST: grumbein, sondra CAS: 91-17-8
------------------------------------------------------------------------------------------------------------------------------------
Final#1, Revision#2
REASONS FOR REMOVAL: 25022 Accidently Killed
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DECALIN DATE: 04/11/02
EXPERIMENT: 93026 TEST: 06 TIME: 09:30:52
TEST TYPE: CHRONIC
CONT: N01-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C93026
PATHOLOGIST: grumbein, sondra CAS: 91-17-8
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 384 421 476 588 606 635 642 649 665 674 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 203 495 497 532 539 561 575 658 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 448 468 561 596 596 602 612 623 654 699 |
| 700 703 715 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 467 469 530 552 593 602 605 616 622 634 |
| 634 692 718 723 723 731 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 96.0 94.0 94.0 92.0 82.0 80.0 |
| | |
| | |
|25 PPM | 100.0 100.0 98.0 98.0 98.0 98.0 90.0 86.0 84.0 82.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 96.0 88.0 82.0 72.0 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 86.0 78.0 68.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 25 PPM 100 PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 82.0% 72.0% 68.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.161 P=1.000N P=0.521 P=0.271 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 574.0 530.9 621.8 619.4 |
|NATURAL DEATHS (C) | (33.8) (47.7) (23.3) (21.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 701.2 696.6 701.9 696.7 |
|(STANDARD ERROR) | (11.2) (13.8) ( 9.6) (10.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 363 568 599 610 616 638 659 659 672 700 |
| 703 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 305 488 527 532 571 588 588 601 616 624 |
| 644 658 658 673 692 692 700 714 722 728 |
| 731 733 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 1 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 3 356 511 612 652 652 672 686 700 700 |
| 710 714 723 734 |
| CENSORED DEATHS |
| 594 |
| |
==================================================================================
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 309 344 432 624 636 644 674 686 710 714 |
| 714 714 721 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 93.9 83.7 75.5 |
| | |
| | |
|25 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 92.0 84.0 74.0 56.0 |
| | |
| | |
|100 PPM | 98.0 98.0 98.0 96.0 96.0 96.0 94.0 94.0 87.9 71.5 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 96.0 96.0 94.0 94.0 94.0 88.0 72.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 25 PPM 100 PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 75.5% 56.0% 71.5% 72.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.570N P=0.068 P=0.868 P=0.926 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 625.1 626.6 601.8 617.8 |
|NATURAL DEATHS (C) | (27.1) (21.6) (53.5) (38.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 708.1 687.3 694.9 702.2 |
|(STANDARD ERROR) | ( 9.4) (12.1) (17.0) (13.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DECALIN
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
25 PPM = 2
100 PPM = 3
400 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3 4
|
| 2 1 1 3 3 2
|
96 + 1 31 4 3
|
| 1 2 2 4 3 1 3
|
P 92 + 22 4 1 4 1
E |
R | 2 2 441 1
C |
E 88 + 2 2 343 11
N |
T | 2 433 112
|
S 84 + 43 12 1 2
U |
R | 4 4 3 1 1 3 2 2
V |
I 80 + 1 1
V |
A | 4 433
L |
76 + 4 3 3
|
| 33
|
72 + 3 3
|
| 4 4
|
68 + 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.
DECALIN
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
25 PPM = 2
100 PPM = 3
400 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 13 2 4 1
|
| 3 2 4 431 2 1
| 43 4 2 3 2 1 1
95 +
| 4 3 1 1 4
| 2 2 3 44 3
|
90 + 2 2 1 41
|
P | 1 3 134
E | 2 2 343
R 85 +
C | 2 2 11 3 3 4
E | 2 2
N | 1 1
T 80 + 2 2 113
|
S | 2 2 11
U | 44
R 75 + 1 3 1
V | 2 2 43 3
I | 2 2 4 4
V | 3
A 70 +
L |
| 22
| 2 2
65 +
| 2 2
|
|
60 + 2 2
|
|
| 2
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.