National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4396

TDMS Study 93026-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 04/11/02       
EXPERIMENT: 93026 TEST: 06                                                                                     TIME: 09:30:52       
TEST TYPE:  CHRONIC                                                                                            PAGE:       1        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: grumbein, sondra                                                                                  CAS: 91-17-8         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                        Final#1, Revision#2                                                         
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 04/11/02       
EXPERIMENT: 93026 TEST: 06                                                                                     TIME: 09:30:52       
TEST TYPE:  CHRONIC                                                                                                                 
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: grumbein, sondra                                                                                  CAS: 91-17-8         
                                                                                                                                   
                                      DECALIN                                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 733 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = CONTROL                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      384   421   476   588   606   635   642   649   665   674                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 25 PPM                                   |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 9      CENSORED DEATHS 0    TERMINAL 41        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      203   495   497   532   539   561   575   658   718                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 100 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      448   468   561   596   596   602   612   623   654   699                 |                                                 
 |      700   703   715   728                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                      DECALIN                                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 733 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 400 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      467   469   530   552   593   602   605   616   622   634                 |                                                 
 |      634   692   718   723   723   731                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                      DECALIN                                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 733 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |CONTROL    |   100.0 100.0 100.0 100.0  96.0  94.0  94.0  92.0  82.0  80.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |25 PPM     |   100.0 100.0  98.0  98.0  98.0  98.0  90.0  86.0  84.0  82.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |100 PPM    |   100.0 100.0 100.0 100.0 100.0  96.0  96.0  88.0  82.0  72.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |400 PPM    |   100.0 100.0 100.0 100.0 100.0  96.0  94.0  86.0  78.0  68.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                CONTROL      25 PPM       100 PPM      400 PPM  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       80.0%        82.0%        72.0%        68.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.161      P=1.000N     P=0.521      P=0.271  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       574.0        530.9        621.8        619.4    |                                                 
 |NATURAL DEATHS (C)      |       (33.8)       (47.7)       (23.3)       (21.3)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       701.2        696.6        701.9        696.7    |                                                 
 |(STANDARD ERROR)        |       (11.2)       (13.8)       ( 9.6)       (10.1)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                      DECALIN                                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 735 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = CONTROL                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 49     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 37        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      363   568   599   610   616   638   659   659   672   700                 |                                                 
 |      703   714                                                                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 25 PPM                                   |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      305   488   527   532   571   588   588   601   616   624                 |                                                 
 |      644   658   658   673   692   692   700   714   722   728                 |                                                 
 |      731   733                                                                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 100 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 1    TERMINAL 35        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      3     356   511   612   652   652   672   686   700   700                 |                                                 
 |      710   714   723   734                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      594                                                                       |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                      DECALIN                                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 735 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 400 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      309   344   432   624   636   644   674   686   710   714                 |                                                 
 |      714   714   721   727                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                      DECALIN                                                                                       
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 735 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |CONTROL    |   100.0 100.0 100.0  98.0  98.0  98.0  98.0  93.9  83.7  75.5      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |25 PPM     |   100.0 100.0 100.0  98.0  98.0  98.0  92.0  84.0  74.0  56.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |100 PPM    |    98.0  98.0  98.0  96.0  96.0  96.0  94.0  94.0  87.9  71.5      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |400 PPM    |   100.0 100.0 100.0  96.0  96.0  94.0  94.0  94.0  88.0  72.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                CONTROL      25 PPM       100 PPM      400 PPM  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       75.5%        56.0%        71.5%        72.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.570N     P=0.068      P=0.868      P=0.926  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       625.1        626.6        601.8        617.8    |                                                 
 |NATURAL DEATHS (C)      |       (27.1)       (21.6)       (53.5)       (38.7)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       708.1        687.3        694.9        702.2    |                                                 
 |(STANDARD ERROR)        |       ( 9.4)       (12.1)       (17.0)       (13.0)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                                              DECALIN                                                               
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        CONTROL          = 1                                                        
                                                        25 PPM           = 2                                                        
                                                        100 PPM          = 3                                                        
                                                        400 PPM          = 4                                                        
                                                                                                                                    
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 + 1                               2                            1        3   4                                                 
      |                                                                                                                             
      |                                 2                            1     1  3   3   2                                             
      |                                                                                                                             
   96 +                                                                    1      31        4    3                                  
      |                                                                                                                             
      |                                                                            1  2     2  4 3  1  3                            
      |                                                                                                                             
P  92 +                                                                                     22 4    1 4 1                           
E     |                                                                                                                             
R     |                                                                                      2   2    441   1                       
C     |                                                                                                                             
E  88 +                                                                                          2 2   343  11                      
N     |                                                                                                                             
T     |                                                                                            2    433  112                    
      |                                                                                                                             
S  84 +                                                                                                  43   12 1       2          
U     |                                                                                                                             
R     |                                                                                                   4 4  3 1 1  3  2  2       
V     |                                                                                                                             
I  80 +                                                                                                            1        1       
V     |                                                                                                                             
A     |                                                                                                     4        433            
L     |                                                                                                                             
   76 +                                                                                                              4 3 3          
      |                                                                                                                             
      |                                                                                                                  33         
      |                                                                                                                             
   72 +                                                                                                                   3 3       
      |                                                                                                                             
      |                                                                                                                   4 4       
      |                                                                                                                             
   68 +                                                                                                                     4       
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 12 obs hidden.                                                                                                                
                                                                                                                                   
                                                              DECALIN                                                               
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        CONTROL          = 1                                                        
                                                        25 PPM           = 2                                                        
                                                        100 PPM          = 3                                                        
                                                        400 PPM          = 4                                                        
                                                                                                                                    
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 + 13                                              2 4      1                                                                  
      |                                                                                                                             
      |  3                                              2 4    431                   2            1                                 
      |                                                        43           4        2  3   2     1    1                            
   95 +                                                                                                                             
      |                                                                     4           3              1 1 4                        
      |                                                                                     2     2      3 44  3                    
      |                                                                                                                             
   90 +                                                                                           2 2    1  41                      
      |                                                                                                                             
P     |                                                                                                      1 3 134                
E     |                                                                                             2  2          343               
R  85 +                                                                                                                             
C     |                                                                                                2 2       11 3 3 4           
E     |                                                                                                  2 2                        
N     |                                                                                                           1   1             
T  80 +                                                                                                    2 2        113           
      |                                                                                                                             
S     |                                                                                                      2 2       11           
U     |                                                                                                                 44          
R  75 +                                                                                                                 1 3 1       
V     |                                                                                                        2   2     43 3       
I     |                                                                                                            2 2    4 4       
V     |                                                                                                                     3       
A  70 +                                                                                                                             
L     |                                                                                                                             
      |                                                                                                              22             
      |                                                                                                               2 2           
   65 +                                                                                                                             
      |                                                                                                                 2 2         
      |                                                                                                                             
      |                                                                                                                             
   60 +                                                                                                                   2 2       
      |                                                                                                                             
      |                                                                                                                             
      |                                                                                                                     2       
   55 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 11 obs hidden.                                                                                                                
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.