National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3995

TDMS Study 93026-07 Pathology Tables

NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26

                                                           FINAL/RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  91-17-8

       Lock Date:  05/31/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           10           10           17                                     
    Natural Death                                      2            5                         5                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Moribund Sacrifice                                                           1                                                  
    Terminal Sacrifice                                32           35           38           28                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (48)         (46)         (49)         (45)                                   
      Muscularis, Inflammation, Chronic                1 (2%)                                                                       
   Liver                                              (50)         (48)         (49)         (50)                                   
      Angiectasis                                      1 (2%)       2 (4%)                    1 (2%)                                
      Basophilic Focus                                              2 (4%)       1 (2%)                                             
      Clear Cell Focus                                 7 (14%)      5 (10%)      4 (8%)       2 (4%)                                
      Congestion                                       1 (2%)                    1 (2%)                                             
      Hepatodiaphragmatic Nodule                       9 (18%)      6 (13%)      6 (12%)      7 (14%)                               
      Inflammation, Granulomatous                                                1 (2%)                                             
      Necrosis                                         2 (4%)       2 (4%)                                                          
      Vacuolization Cytoplasmic                        3 (6%)                    2 (4%)                                             
      Bile Duct, Hyperplasia                           1 (2%)                                                                       
      Hepatocyte, Regeneration                                      1 (2%)                                                          
      Periportal, Pigmentation                                                   1 (2%)                                             
      Serosa, Hemorrhage                                            1 (2%)                                                          
   Mesentery                                          (26)         (20)         (20)         (17)                                   
      Necrosis                                        26 (100%)    20 (100%)    20 (100%)    16 (94%)                               
   Oral Mucosa                                        (1)                                    (2)                                    
      Inflammation, Chronic                            1 (100%)                                                                     
      Pharyngeal, Hyperplasia, Squamous                                                       2 (100%)                              
   Pancreas                                           (50)         (47)         (49)         (49)                                   
      Acinus, Atrophy                                  1 (2%)                                 1 (2%)                                
   Stomach, Forestomach                               (50)         (47)         (49)         (49)                                   
      Erosion                                                                                 1 (2%)                                
      Hyperplasia, Squamous                            1 (2%)                    1 (2%)       1 (2%)                                
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            2 (4%)       2 (4%)       1 (2%)                                             
   Stomach, Glandular                                 (50)         (47)         (49)         (49)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mineralization                                   1 (2%)                                                                       
   Tongue                                             (2)                                    (1)                                    
      Epithelium, Hyperplasia                                                                 1 (100%)                              
   Tooth                                              (1)                                                                           
      Pulp, Inflammation, Suppurative                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)                                   
      Cardiomyopathy                                   1 (2%)                    1 (2%)                                             
      Artery, Mineralization                           1 (2%)                                                                       
      Atrium, Thrombosis                               2 (4%)       2 (4%)       1 (2%)                                             
      Ventricle, Angiectasis                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (48)         (49)         (49)                                   
      Hyperplasia                                      3 (6%)                    2 (4%)       2 (4%)                                
      Hypertrophy                                      1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
      Vacuolization Cytoplasmic                        7 (14%)      7 (15%)     11 (22%)      8 (16%)                               
   Adrenal Medulla                                    (50)         (48)         (49)         (49)                                   
      Hyperplasia                                      3 (6%)       2 (4%)                                                          
   Islets, Pancreatic                                 (50)         (47)         (49)         (49)                                   
      Hyperplasia                                                                1 (2%)                                             
   Parathyroid Gland                                  (49)         (48)         (48)         (47)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (50)         (49)         (49)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             1 (2%)       4 (8%)       3 (6%)                                             
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Pars Distalis, Angiectasis                       2 (4%)                                                                       
      Pars Distalis, Hyperplasia                       7 (14%)      9 (18%)      8 (16%)      5 (10%)                               
   Thyroid Gland                                      (50)         (49)         (49)         (50)                                   
      C-Cell, Hyperplasia                             15 (30%)      7 (14%)      6 (12%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (49)         (50)                                   
      Cyst                                             2 (4%)       3 (6%)       2 (4%)       1 (2%)                                
      Hyperplasia                                      3 (6%)       3 (6%)       1 (2%)       3 (6%)                                
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
   Ovary                                              (50)         (50)         (49)         (50)                                   
      Cyst                                             3 (6%)       4 (8%)       6 (12%)      3 (6%)                                
   Uterus                                             (50)         (49)         (49)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Endometrium, Hyperplasia                                      3 (6%)                    1 (2%)                                
      Endometrium, Inflammation, Suppurative                                     1 (2%)                                             
      Endometrium, Metaplasia, Squamous                             1 (2%)                                                          
   Vagina                                             (1)                                    (2)                                    
      Epithelium, Hyperplasia                                                                 1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (6)                       (4)          (2)                                    
      Hyperplasia, Lymphoid                            1 (17%)                                                                      
      Deep Cervical, Ectasia                           1 (17%)                                1 (50%)                               
      Deep Cervical, Hyperplasia, Lymphoid                                       1 (25%)                                            
      Deep Cervical, Infiltration Cellular,                                                                                         
          Histiocyte                                   1 (17%)                                                                      
      Deep Cervical, Pigmentation                      1 (17%)                                                                      
      Pancreatic, Pigmentation                                                   1 (25%)                                            
      Thoracic, Hyperplasia, Plasma Cell                                                      1 (50%)                               
   Lymph Node, Bronchial                              (2)          (10)         (7)          (5)                                    
      Ectasia                                          1 (50%)      1 (10%)                                                         
      Infiltration Cellular, Histiocyte                                          1 (14%)                                            
      Inflammation, Suppurative                        1 (50%)                                                                      
      Pigmentation                                                  2 (20%)                   1 (20%)                               
   Lymph Node, Mediastinal                            (45)         (46)         (49)         (44)                                   
      Angiectasis                                      1 (2%)       2 (4%)                    1 (2%)                                
      Hyperplasia, Plasma Cell                                                                1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Pigmentation                                                  1 (2%)                                                          
   Spleen                                             (50)         (49)         (49)         (50)                                   
      Accessory Spleen                                 1 (2%)       1 (2%)                    1 (2%)                                
      Fibrosis                                         1 (2%)                                 3 (6%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)       2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                       3 (6%)                                                                       
      Necrosis                                                      1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Galactocele                                      3 (6%)       1 (2%)       5 (10%)      1 (2%)                                
   Skin                                               (50)         (50)         (49)         (50)                                   
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Erosion                                                                                 1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fracture                                                                   1 (2%)                                             
      Cranium, Hemorrhage                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (49)         (50)                                   
      Compression                                      6 (12%)      5 (10%)      6 (12%)      3 (6%)                                
      Hemorrhage                                       1 (2%)       1 (2%)       3 (6%)       6 (12%)                               
      Thrombosis                                                                 1 (2%)                                             
      Cerebrum, Gliosis                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (49)         (48)                                   
      Foreign Body                                                  1 (2%)                    3 (6%)                                
      Inflammation, Chronic                            2 (4%)       4 (8%)       2 (4%)       2 (4%)                                
      Inflammation, Suppurative                                     2 (4%)                    4 (8%)                                
      Epiglottis, Metaplasia, Squamous                              1 (2%)       1 (2%)                                             
      Respiratory Epithelium, Hyperplasia                           1 (2%)                                                          
      Respiratory Epithelium, Metaplasia, Squamous                                            1 (2%)                                
      Respiratory Epithelium, Epiglottis,                                                                                           
          Degeneration                                              1 (2%)       1 (2%)                                             
      Squamous Epithelium, Hyperplasia                                                        1 (2%)                                
   Lung                                               (50)         (50)         (49)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Congestion                                                                              1 (2%)                                
      Foreign Body                                                                            1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 9 (18%)     14 (28%)      8 (16%)     14 (28%)                               
      Alveolar Epithelium, Metaplasia, Squamous                                  1 (2%)       2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte     21 (42%)     26 (52%)     29 (59%)     29 (58%)                               
      Alveolus, Pigmentation                                                                  1 (2%)                                
      Alveolus, Proteinosis                           11 (22%)     16 (32%)     15 (31%)     23 (46%)                               
      Bronchiole, Mineralization                       1 (2%)                                                                       
      Interstitium, Fibrosis                          16 (32%)     24 (48%)     23 (47%)     28 (56%)                               
      Interstitium, Inflammation, Chronic              1 (2%)       6 (12%)      6 (12%)      4 (8%)                                
      Mediastinum, Hyperplasia, Histiocytic                                                   1 (2%)                                
      Mediastinum, Pigmentation                                                               1 (2%)                                
      Perivascular, Pigmentation                       1 (2%)                                                                       
   Nose                                               (50)         (48)         (49)         (49)                                   
      Foreign Body                                     1 (2%)       4 (8%)       3 (6%)       1 (2%)                                
      Inflammation, Suppurative                        3 (6%)       5 (10%)      7 (14%)      3 (6%)                                
      Goblet Cell, Hyperplasia                         1 (2%)       1 (2%)       5 (10%)      2 (4%)                                
      Nasolacrimal Duct, Inflammation, Suppurative     3 (6%)       1 (2%)       1 (2%)       3 (6%)                                
      Olfactory Epithelium, Degeneration, Hyaline                                             1 (2%)                                
      Respiratory Epithelium, Hyperplasia                           1 (2%)       1 (2%)       2 (4%)                                
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
   Pleura                                             (20)         (25)         (25)         (28)                                   
      Inflammation, Chronic                           15 (75%)     17 (68%)     23 (92%)     27 (96%)                               
      Mesothelium, Hyperplasia                         2 (10%)      7 (28%)      8 (32%)      2 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (5)          (4)                                    
      Atrophy                                                       2 (100%)                                                        
      Anterior Chamber, Hemorrhage                                                            1 (25%)                               
      Choroid, Sclera, Mineralization                                            1 (20%)                                            
      Cornea, Hyperplasia                                                                     1 (25%)                               
      Cornea, Inflammation, Suppurative                             1 (50%)                                                         
      Lens, Cataract                                   1 (100%)                  3 (60%)      2 (50%)                               
   Harderian Gland                                    (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (46)         (49)         (50)                                   
      Cyst                                             1 (2%)       2 (4%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cytoplasmic Alteration                           1 (2%)                                 1 (2%)                                
      Nephropathy, Chronic                            44 (88%)     45 (98%)     48 (98%)     48 (96%)                               
      Cortex, Renal Tubule, Hyperplasia                1 (2%)       4 (9%)       4 (8%)       2 (4%)                                
      Papilla, Mineralization                          3 (6%)       2 (4%)       4 (8%)       4 (8%)                                
      Pelvis, Dilatation                               1 (2%)                    1 (2%)       1 (2%)                                
      Pelvis, Mineralization                          11 (22%)     16 (35%)     19 (39%)     18 (36%)                               
      Pelvis, Transitional Epithelium, Hyperplasia                  2 (4%)       2 (4%)       2 (4%)                                
      Renal Tubule, Mineralization                     1 (2%)                                                                       
      Renal Tubule, Pigmentation                                                              1 (2%)                                
   Ureter                                             (1)                                                                           
      Mineralization                                   1 (100%)                                                                     
      Necrosis                                         1 (100%)                                                                     
   Urinary Bladder                                    (50)         (47)         (49)         (50)                                   
      Degeneration                                                  1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)       1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50           20                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           21           23           23            6                        
    Natural Death                                      5            6            3            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           23           23           20           14                        
  Other                                                                          1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           49           50           20                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (47)         (48)         (49)         (20)                      
      Ulcer                                                                      1 (2%)                                             
   Liver                                              (50)         (50)         (49)         (50)         (20)                      
      Angiectasis                                                                             1 (2%)       1 (5%)                   
      Clear Cell Focus                                 2 (4%)       1 (2%)       3 (6%)       3 (6%)                                
      Congestion                                                                 1 (2%)                                             
      Cyst                                             1 (2%)                    1 (2%)                                             
      Degeneration, Cystic                             1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       7 (14%)      5 (10%)      7 (14%)      4 (8%)       4 (20%)                  
      Infiltration Cellular, Lymphohistiocytic                                                             2 (10%)                  
      Mixed Cell Focus                                 3 (6%)                    1 (2%)                                             
      Necrosis                                         1 (2%)       1 (2%)       2 (4%)                                             
      Thrombosis                                                    1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic                                     2 (4%)       1 (2%)       1 (2%)                                
      Bile Duct, Hyperplasia                                                     2 (4%)       1 (2%)       3 (15%)                  
      Hepatocyte, Regeneration                         2 (4%)       1 (2%)       4 (8%)       2 (4%)       1 (5%)                   
   Mesentery                                          (16)         (19)         (20)         (13)         (10)                      
      Necrosis                                         7 (44%)      9 (47%)     12 (60%)      4 (31%)      2 (20%)                  
      Artery, Inflammation                                                                                 1 (10%)                  
      Fat, Hemorrhage                                                            2 (10%)                   2 (20%)                  
      Fat, Necrosis                                    9 (56%)      6 (32%)      6 (30%)      6 (46%)      5 (50%)                  
   Oral Mucosa                                                     (2)          (2)          (1)                                    
      Inflammation, Chronic                                                                   1 (100%)                              
      Pharyngeal, Hyperplasia, Squamous                             1 (50%)                                                         
   Pancreas                                           (50)         (50)         (49)         (50)         (20)                      
      Acinus, Atrophy                                  1 (2%)       2 (4%)       3 (6%)       2 (4%)       2 (10%)                  
      Acinus, Hyperplasia                                                                     1 (2%)                                
   Salivary Glands                                    (50)         (50)         (49)         (50)         (20)                      
      Inflammation, Suppurative                                                  1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (50)         (50)         (49)         (50)         (20)                      
      Erosion                                          1 (2%)                                                                       
      Hyperplasia, Squamous                                                                   1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)       1 (5%)                   
      Ulcer                                                         5 (10%)      4 (8%)       3 (6%)       1 (5%)                   
   Stomach, Glandular                                 (50)         (50)         (49)         (50)         (20)                      
      Erosion                                                       1 (2%)       1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
      Ulcer                                                         1 (2%)       2 (4%)                                             
   Tongue                                                          (1)          (2)          (1)                                    
      Inflammation                                                               1 (50%)                                            
   Tooth                                              (1)                       (1)                       (1)                       
      Inflammation                                                               1 (100%)                                           
      Peridontal Tissue, Inflammation                  1 (100%)                                            1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (44)         (50)         (49)         (45)         (11)                      
      Thrombosis                                                                                           1 (9%)                   
      Pulmonary Artery, Inflammation                                                                       1 (9%)                   
   Heart                                              (50)         (50)         (49)         (50)         (20)                      
      Cardiomyopathy                                   5 (10%)      5 (10%)      4 (8%)       9 (18%)      3 (15%)                  
      Atrium, Thrombosis                               2 (4%)       2 (4%)       5 (10%)      2 (4%)       1 (5%)                   
      Valve, Thrombosis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)         (20)                      
      Hyperplasia                                      1 (2%)       1 (2%)       3 (6%)                                             
      Necrosis                                                                   1 (2%)       2 (4%)                                
      Vacuolization Cytoplasmic                        2 (4%)       6 (12%)      5 (10%)      2 (4%)       1 (5%)                   
   Adrenal Medulla                                    (49)         (49)         (49)         (49)         (20)                      
      Hyperplasia                                     10 (20%)     13 (27%)     26 (53%)     17 (35%)      4 (20%)                  
      Necrosis                                                      1 (2%)                    1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)         (20)                      
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
   Parathyroid Gland                                  (49)         (48)         (49)         (49)         (20)                      
      Hyperplasia                                                                             1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (49)         (49)         (20)                      
      Cyst                                             1 (2%)       1 (2%)       1 (2%)                    1 (5%)                   
      Hemorrhage                                       1 (2%)                                 2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia                       7 (14%)      4 (8%)       5 (10%)      6 (12%)      1 (5%)                   
      Pars Intermedia, Hyperplasia                                                            1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (49)         (49)         (20)                      
      C-Cell, Hyperplasia                              6 (12%)      6 (12%)      6 (12%)                   7 (35%)                  
      Follicular Cell, Hyperplasia                                  1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)         (20)                      
      Spermatocele                                                                            1 (2%)                                
   Preputial Gland                                    (50)         (49)         (49)         (50)         (20)                      
      Hyperplasia                                      1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                    1 (2%)                                
   Prostate, NOS                                      (50)         (50)         (49)         (50)         (20)                      
      Hyperplasia                                      1 (2%)       3 (6%)                                                          
      Hypertrophy                                                                             1 (2%)                                
      Inflammation                                                                                         2 (10%)                  
      Inflammation, Suppurative                       18 (36%)     21 (42%)     14 (29%)     24 (48%)      9 (45%)                  
      Epithelium, Dorsal, Hyperplasia                                                                      1 (5%)                   
      Epithelium, Ventral, Hyperplasia                                           1 (2%)       1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (49)         (50)         (20)                      
      Dilatation                                                                              1 (2%)                                
   Testes                                             (50)         (50)         (49)         (50)         (20)                      
      Artery, Inflammation                                                                    1 (2%)                                
      Germinal Epithelium, Atrophy                     6 (12%)      4 (8%)       8 (16%)      7 (14%)      4 (20%)                  
      Interstitial Cell, Hyperplasia                   9 (18%)     17 (34%)      7 (14%)     16 (32%)      1 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)         (20)                      
      Hyperplasia, Reticulum Cell                                                             1 (2%)                                
      Myelofibrosis                                                              1 (2%)                    1 (5%)                   
   Lymph Node                                         (8)          (10)         (14)         (11)         (1)                       
      Ectasia                                                                    1 (7%)                                             
      Deep Cervical, Infiltration Cellular,                                                                                         
          Histiocyte                                                             1 (7%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Deep Cervical, Inflammation, Suppurative                                                1 (9%)                                
      Pancreatic, Ectasia                              1 (13%)                                1 (9%)                                
      Pancreatic, Pigmentation                                                   1 (7%)                                             
   Lymph Node, Bronchial                              (7)          (8)          (18)         (17)         (7)                       
      Ectasia                                                                    1 (6%)                    1 (14%)                  
      Inflammation, Chronic                                                                                1 (14%)                  
      Pigmentation                                                                            1 (6%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (49)         (20)                      
      Ectasia                                                                    1 (2%)       1 (2%)                                
      Hyperplasia, Lymphohistiocytic                                             1 (2%)                                             
   Lymph Node, Mediastinal                            (48)         (45)         (44)         (48)         (16)                      
      Angiectasis                                                   3 (7%)       1 (2%)       2 (4%)       1 (6%)                   
      Inflammation                                     1 (2%)                                                                       
      Inflammation, Chronic                                                                   1 (2%)                                
      Pigmentation                                                                            1 (2%)                                
   Spleen                                             (50)         (50)         (49)         (50)         (20)                      
      Accessory Spleen                                 1 (2%)                                 2 (4%)       2 (10%)                  
      Congestion                                                                 4 (8%)                                             
      Fibrosis                                         3 (6%)       3 (6%)       4 (8%)       5 (10%)      2 (10%)                  
      Hematopoietic Cell Proliferation                              1 (2%)                    3 (6%)                                
      Hemorrhage                                                    5 (10%)      2 (4%)       2 (4%)       1 (5%)                   
      Hyperplasia, Lymphoid                                                                                1 (5%)                   
      Hyperplasia, Lymphohistiocytic                                             1 (2%)                    1 (5%)                   
      Necrosis                                         1 (2%)       1 (2%)       2 (4%)       2 (4%)       1 (5%)                   
   Thymus                                             (50)         (48)         (47)         (50)         (20)                      
      Cyst                                                          1 (2%)                    1 (2%)                                
      Metaplasia, Squamous                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)         (20)                      
      Galactocele                                                   2 (4%)                                 1 (5%)                   
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Skin                                               (50)         (50)         (49)         (50)         (20)                      
      Cyst                                             3 (6%)       1 (2%)                                                          
      Cyst Epithelial Inclusion                        2 (4%)       2 (4%)       5 (10%)                                            
      Hyperkeratosis                                   2 (4%)       1 (2%)                    1 (2%)       1 (5%)                   
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                                                                1 (5%)                   
      Ulcer                                                         1 (2%)                    2 (4%)                                
      Subcutaneous Tissue, Fibrosis                                 1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Hemorrhage                                                         1 (2%)                                
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)         (20)                      
      Femur, Degeneration                                                        1 (2%)                                             
      Joint, Femur, Tibia, Fracture                                              1 (2%)                                             
      Vertebra, Fracture                               1 (2%)                                                                       
   Skeletal Muscle                                                 (1)                       (5)                                    
      Inflammation, Chronic                                                                   1 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)         (20)                      
      Compression                                      2 (4%)       2 (4%)       5 (10%)      5 (10%)      1 (5%)                   
      Hemorrhage                                       2 (4%)       1 (2%)       2 (4%)       3 (6%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (49)         (49)         (20)                      
      Foreign Body                                     2 (4%)       1 (2%)       3 (6%)       2 (4%)                                
      Inflammation, Chronic                            2 (4%)                    3 (6%)       2 (4%)       1 (5%)                   
      Inflammation, Suppurative                        1 (2%)       1 (2%)       1 (2%)       1 (2%)       1 (5%)                   
      Metaplasia, Squamous                             1 (2%)                                                                       
      Epiglottis, Hyperplasia                                                    1 (2%)                    1 (5%)                   
      Epiglottis, Metaplasia, Squamous                                                                     1 (5%)                   
      Glands, Degeneration                                          1 (2%)                                                          
      Squamous Epithelium, Hyperplasia                                           1 (2%)                                             
   Lung                                               (50)         (50)         (49)         (50)         (20)                      
      Hemorrhage                                       1 (2%)                    4 (8%)       3 (6%)                                
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       2 (4%)                                
      Mineralization                                                             1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                10 (20%)      8 (16%)      6 (12%)      9 (18%)      4 (20%)                  
      Alveolar Epithelium, Metaplasia, Squamous        1 (2%)       1 (2%)       1 (2%)                    1 (5%)                   
      Alveolus, Infiltration Cellular, Histiocyte     14 (28%)     15 (30%)      6 (12%)     11 (22%)     10 (50%)                  
      Alveolus, Pigmentation                           1 (2%)                                                                       
      Alveolus, Proteinosis                            6 (12%)      7 (14%)      2 (4%)       4 (8%)       2 (10%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Bronchiole, Hyperplasia                          1 (2%)                                                                       
      Bronchiole, Metaplasia, Squamous                              1 (2%)                                                          
      Goblet Cell, Hyperplasia                                                                1 (2%)                                
      Interstitium, Fibrosis                           9 (18%)     10 (20%)      7 (14%)      6 (12%)      4 (20%)                  
      Interstitium, Inflammation, Chronic              5 (10%)      2 (4%)       2 (4%)       1 (2%)       1 (5%)                   
   Nose                                               (49)         (49)         (49)         (50)         (20)                      
      Foreign Body                                     1 (2%)       4 (8%)       2 (4%)                    1 (5%)                   
      Inflammation, Suppurative                        2 (4%)       4 (8%)       8 (16%)      4 (8%)                                
      Goblet Cell, Hyperplasia                                      1 (2%)       2 (4%)       2 (4%)       1 (5%)                   
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                                                                       
      Respiratory Epithelium, Hyperplasia              1 (2%)                                 1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous                               1 (2%)                                             
      Respiratory Epithelium, Necrosis                 1 (2%)                                                                       
   Pleura                                             (9)          (8)          (8)          (5)          (6)                       
      Inflammation, Chronic                            9 (100%)     7 (88%)      6 (75%)      4 (80%)      5 (83%)                  
      Mesothelium, Hyperplasia                                      1 (13%)      3 (38%)                   1 (17%)                  
   Trachea                                            (50)         (50)         (49)         (49)         (20)                      
      Inflammation, Suppurative                                                               1 (2%)                                
      Metaplasia, Squamous                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (2)          (2)          (2)          (1)                       
      Atrophy                                                                                 1 (50%)                               
      Inflammation, Suppurative                                     1 (50%)                                                         
      Anterior Chamber, Hemorrhage                                  1 (50%)                                                         
      Lens, Cataract                                                1 (50%)      1 (50%)      2 (100%)     1 (100%)                 
   Harderian Gland                                    (1)                                    (2)                                    
      Inflammation, Chronic                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)         (20)                      
      Cyst                                                                       2 (4%)       1 (2%)                                
      Glomerulosclerosis                                                         1 (2%)                                             
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          1 (2%)       1 (2%)       1 (2%)                    1 (5%)                   
      Inflammation, Suppurative                                                               1 (2%)                                
      Nephropathy, Chronic                            48 (96%)     48 (96%)     49 (100%)    50 (100%)    20 (100%)                 
      Cortex, Renal Tubule, Accumulation, Hyaline                                                                                   
          Droplet                                      2 (4%)       9 (18%)      7 (14%)     11 (22%)      2 (10%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 93026-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                              DECALIN                                          Date: 09/26/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cortex, Renal Tubule, Atypia Cellular            1 (2%)                                                                       
      Cortex, Renal Tubule, Hyperplasia                            11 (22%)     11 (22%)     15 (30%)      5 (25%)                  
      Cortex, Renal Tubule, Mineralization                                                    1 (2%)                                
      Medulla, Casts Granular                                                                              1 (5%)                   
      Papilla, Mineralization                          1 (2%)      34 (68%)     41 (84%)     43 (86%)     17 (85%)                  
      Pelvis, Inflammation, Suppurative                1 (2%)                                                                       
      Pelvis, Transitional Epithelium, Hyperplasia     1 (2%)       8 (16%)      8 (16%)     10 (20%)      5 (25%)                  
   Urinary Bladder                                    (50)         (49)         (49)         (49)         (20)                      
      Calculus Micro Observation Only                                                         1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Muscularis, Hyperplasia                                                                              1 (5%)                   
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.