TDMS Study 93026-07 Pathology Tables
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 FINAL#1 Facility: Battelle Northwest Chemical CAS #: 91-17-8 Lock Date: 05/31/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Moribund Sacrifice 16 10 10 17 Natural Death 2 5 5 Accidently Killed 1 Survivors Moribund Sacrifice 1 Terminal Sacrifice 32 35 38 28 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (50) (48) (49) (50) Histiocytic Sarcoma 1 (2%) Mesentery (26) (20) (20) (17) Oral Mucosa (1) (2) Gingival, Squamous Cell Carcinoma 1 (100%) Stomach, Glandular (50) (47) (49) (49) Adenoma 1 (2%) Tongue (2) (1) Squamous Cell Carcinoma 1 (50%) Squamous Cell Papilloma 1 (50%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Medulla (50) (48) (49) (49) Pheochromocytoma Malignant 2 (4%) 1 (2%) Pheochromocytoma Benign 1 (2%) 1 (2%) 3 (6%) 1 (2%) Islets, Pancreatic (50) (47) (49) (49) Adenoma 1 (2%) Carcinoma 1 (2%) 1 (2%) 1 (2%) Pituitary Gland (50) (49) (49) (50) Pars Distalis, Adenoma 34 (68%) 27 (55%) 29 (59%) 30 (60%) Page 2 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Pars Distalis, Carcinoma 1 (2%) 1 (2%) 1 (2%) Thyroid Gland (50) (49) (49) (50) C-Cell, Adenoma 5 (10%) 3 (6%) 2 (4%) 3 (6%) C-Cell, Carcinoma 3 (6%) 1 (2%) Follicular Cell, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (48) (49) (49) (50) Adenoma 8 (17%) 2 (4%) 1 (2%) Carcinoma 1 (2%) 3 (6%) 1 (2%) 1 (2%) Ovary (50) (50) (49) (50) Granulosa Cell Tumor Malignant 1 (2%) Granulosa Cell Tumor Benign 2 (4%) Thecoma Malignant 1 (2%) Uterus (50) (49) (49) (50) Polyp Stromal 6 (12%) 8 (16%) 14 (29%) 12 (24%) Sarcoma Stromal 1 (2%) Bilateral, Polyp Stromal 1 (2%) Endometrium, Carcinoma 2 (4%) 1 (2%) Vagina (1) (2) Sarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (49) (49) (50) Lymph Node (6) (4) (2) Lymph Node, Bronchial (2) (10) (7) (5) Carcinoma, Metastatic, Uterus 1 (14%) Lymph Node, Mesenteric (50) (50) (49) (49) Lymph Node, Mediastinal (45) (46) (49) (44) Spleen (50) (49) (49) (50) Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (49) (50) Carcinoma 5 (10%) 3 (6%) 6 (12%) 3 (6%) Fibroadenoma 17 (34%) 14 (28%) 17 (35%) 18 (36%) Fibroadenoma, Multiple 8 (16%) 8 (16%) 3 (6%) 5 (10%) Skin (50) (50) (49) (50) Basal Cell Adenoma 1 (2%) Basal Cell Carcinoma 1 (2%) 1 (2%) Sarcoma 1 (2%) Squamous Cell Carcinoma 1 (2%) Squamous Cell Papilloma 1 (2%) Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%) Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%) Subcutaneous Tissue, Neural Crest Tumor 1 (2%) 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) Subcutaneous Tissue, Schwannoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Humerus, Osteosarcoma 1 (2%) 1 (2%) Skeletal Muscle (1) (2) (1) Carcinoma, Metastatic, Uterus 1 (100%) Carcinoma, Metastatic, Zymbal's Gland 1 (50%) Osteosarcoma, Metastatic, Bone 1 (50%) Rhabdomyosarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (49) (49) (50) Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (49) (50) Alveolar/Bronchiolar Adenoma 1 (2%) Alveolar/Bronchiolar Carcinoma 1 (2%) Carcinoma, Metastatic, Uterus 1 (2%) 1 (2%) Granulosa Cell Tumor Malignant, Metastatic, Ovary 1 (2%) Page 4 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont Osteosarcoma, Metastatic, Bone 1 (2%) Pheochromocytoma Malignant, Metastatic, Adrenal Medulla 1 (2%) Pleura (20) (25) (25) (28) Carcinoma, Metastatic, Uterus 1 (4%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (46) (49) (50) Granulosa Cell Tumor Malignant, Metastatic, Ovary 1 (2%) Pelvis, Transitional Epithelium, Carcinoma 1 (2%) Urinary Bladder (50) (47) (49) (50) Sarcoma, Metastatic, Vagina 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) Leukemia Mononuclear 11 (22%) 15 (30%) 12 (24%) 14 (28%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 49 44 46 48 Total Primary Neoplasms 114 96 103 95 Total Animals with Benign Neoplasms 46 41 44 44 Total Benign Neoplasms 83 66 72 72 Total Animals with Malignant Neoplasms 25 22 25 18 Total Malignant Neoplasms 30 30 31 22 Total Animals with Metastatic Neoplasms 1 4 2 2 Total Metastatic Neoplasm 1 6 5 2 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 1 1 Total Uncertain Neoplasms 1 1 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 20 Early Deaths Moribund Sacrifice 17 21 23 23 6 Natural Death 5 6 3 7 Survivors Terminal Sacrifice 28 23 23 20 14 Other 1 Animals Examined Microscopically 50 50 49 50 20 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (48) (47) (48) (49) (20) Polyp Adenomatous 1 (2%) Intestine Small, Jejunum (47) (45) (46) (47) (20) Intestine Small, Ileum (46) (45) (46) (48) (20) Leiomyoma 1 (2%) Liver (50) (50) (49) (50) (20) Histiocytic Sarcoma 1 (2%) Histiocytic Sarcoma, Metastatic, Skeletal Muscle 1 (2%) Mesentery (16) (19) (20) (13) (10) Carcinoma, Metastatic, Urinary Bladder 1 (5%) Schwannoma Malignant 1 (8%) Oral Mucosa (2) (2) (1) Pharyngeal, Squamous Cell Carcinoma 1 (100%) Pharyngeal, Squamous Cell Papilloma 1 (50%) 2 (100%) Pancreas (50) (50) (49) (50) (20) Carcinoma 1 (2%) Carcinoma, Metastatic, Kidney 1 (2%) Salivary Glands (50) (50) (49) (50) (20) Sarcoma 1 (2%) Schwannoma Malignant 1 (2%) Stomach, Glandular (50) (50) (49) (50) (20) Tongue (1) (2) (1) Squamous Cell Papilloma 1 (100%) 1 (50%) ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (49) (50) (20) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Medulla (49) (49) (49) (49) (20) Pheochromocytoma Malignant 2 (4%) 2 (4%) 7 (14%) 3 (15%) Pheochromocytoma Benign 7 (14%) 8 (16%) 10 (20%) 9 (18%) 4 (20%) Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%) 1 (2%) 2 (10%) Islets, Pancreatic (50) (50) (49) (50) (20) Adenoma 3 (6%) 3 (6%) 3 (6%) 2 (4%) 1 (5%) Carcinoma 4 (8%) 1 (2%) 4 (8%) Pituitary Gland (50) (50) (49) (49) (20) Craniopharyngeal Duct, Craniopharyngioma 1 (2%) Pars Distalis, Adenoma 27 (54%) 33 (66%) 25 (51%) 25 (51%) 9 (45%) Pars Distalis, Carcinoma 1 (2%) 1 (2%) Thyroid Gland (50) (50) (49) (49) (20) C-Cell, Adenoma 7 (14%) 4 (8%) 4 (8%) 3 (6%) 2 (10%) C-Cell, Carcinoma 2 (4%) 1 (2%) Follicular Cell, Carcinoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Peritoneum (2) (2) (2) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (49) (50) (20) Preputial Gland (50) (49) (49) (50) (20) Adenoma 1 (2%) 1 (2%) Carcinoma 1 (2%) 1 (2%) 3 (6%) 2 (10%) Prostate, NOS (50) (50) (49) (50) (20) Carcinoma, Metastatic, Urinary Bladder 1 (2%) Ventral, Adenoma 1 (2%) Seminal Vesicle (50) (50) (49) (50) (20) Carcinoma, Metastatic, Kidney 1 (2%) Testes (50) (50) (49) (50) (20) Bilateral, Interstitial Cell, Adenoma 34 (68%) 31 (62%) 39 (80%) 29 (58%) 16 (80%) Interstitial Cell, Adenoma 6 (12%) 10 (20%) 8 (16%) 15 (30%) 4 (20%) ____________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (49) (50) (20) Histiocytic Sarcoma 1 (2%) Lymph Node (8) (10) (14) (11) (1) Deep Cervical, Carcinoma, Metastatic, Kidney 1 (10%) Pancreatic, Histiocytic Sarcoma 1 (10%) Lymph Node, Bronchial (7) (8) (18) (17) (7) Lymph Node, Mandibular (3) (2) (3) (1) Lymph Node, Mesenteric (50) (50) (49) (49) (20) Carcinoma, Metastatic, Urinary Bladder 1 (2%) Histiocytic Sarcoma, Metastatic, Skeletal Muscle 1 (2%) Lymph Node, Mediastinal (48) (45) (44) (48) (16) Carcinoma, Metastatic, Kidney 1 (2%) Spleen (50) (50) (49) (50) (20) Capsule, Carcinoma, Metastatic, Kidney 1 (2%) Thymus (50) (48) (47) (50) (20) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (49) (50) (20) Adenoma 1 (2%) Carcinoma 1 (2%) 1 (2%) 1 (2%) Fibroadenoma 2 (4%) 1 (2%) 3 (6%) 1 (2%) Skin (50) (50) (49) (50) (20) Basal Cell Adenoma 1 (2%) 2 (4%) 1 (5%) Keratoacanthoma 1 (2%) 2 (4%) 1 (2%) Squamous Cell Papilloma 1 (2%) 1 (2%) Trichoepithelioma 1 (2%) Pinna, Neural Crest Tumor 1 (2%) 1 (2%) Subcutaneous Tissue, Fibroma 2 (4%) 5 (10%) 3 (6%) 2 (4%) 1 (5%) Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%) Subcutaneous Tissue, Schwannoma Benign 1 (2%) Subcutaneous Tissue, Schwannoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ Page 9 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (49) (50) (20) Osteosarcoma 1 (2%) Cranium, Osteoma 1 (2%) Cranium, Squamous Cell Carcinoma, Metastatic, Oral Mucosa 1 (2%) Skeletal Muscle (1) (5) Histiocytic Sarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (49) (50) (20) Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (49) (50) (20) Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 2 (4%) 1 (2%) Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (5%) Carcinoma, Metastatic, Kidney 1 (2%) 1 (2%) Carcinoma, Metastatic, Urinary Bladder 1 (2%) Histiocytic Sarcoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma, Metastatic, Skeletal Muscle 1 (2%) Neural Crest Tumor, Metastatic, Skin 1 (2%) Pleura (9) (8) (8) (5) (6) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (2) (2) (2) (1) Carcinoma, Metastatic, Pituitary Gland 1 (50%) Harderian Gland (1) (2) Squamous Cell Carcinoma, Metastatic, Oral Mucosa 1 (50%) Zymbal's Gland (2) (2) Carcinoma 2 (100%) 2 (100%) ____________________________________________________________________________________________________________________________________ Page 10 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (49) (50) (20) Histiocytic Sarcoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma, Metastatic, Skeletal Muscle 1 (2%) Bilateral, Renal Tubule, Carcinoma 1 (2%) Cortex, Renal Tubule, Adenoma 1 (2%) 2 (4%) 6 (12%) 9 (18%) 3 (15%) Cortex, Renal Tubule, Adenoma, Multiple 1 (5%) Cortex, Renal Tubule, Carcinoma 1 (2%) 4 (8%) 1 (5%) Pelvis, Transitional Epithelium, Carcinoma 1 (2%) Pelvis, Transitional Epithelium, Papilloma 1 (2%) Renal Tubule, Adenoma 1 (5%) Urinary Bladder (50) (49) (49) (49) (20) Transitional Epithelium, Carcinoma 1 (2%) Transitional Epithelium, Papilloma 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(49) *(50) *(20) Histiocytic Sarcoma 2 (4%) Leukemia Mononuclear 19 (38%) 23 (46%) 27 (55%) 25 (50%) 10 (50%) Lymphoma Malignant 1 (2%) 1 (2%) Mesothelioma Malignant 1 (2%) 2 (4%) 2 (4%) 5 (10%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 11 NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DECALIN Date: 08/24/01 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 49 50 49 50 20 Total Primary Neoplasms 127 145 154 161 62 Total Animals with Benign Neoplasms 47 49 49 48 20 Total Benign Neoplasms 94 111 111 102 45 Total Animals with Malignant Neoplasms 27 28 32 42 13 Total Malignant Neoplasms 32 34 42 59 17 Total Animals with Metastatic Neoplasms 5 2 4 Total Metastatic Neoplasm 18 2 16 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 1 1 Total Uncertain Neoplasms 1 1 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------