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TDMS Study 93026-07 Pathology Tables

NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28

                                                            FINAL#1




       Facility:  Battelle Northwest

       Chemical CAS #:  91-17-8

       Lock Date:  05/31/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           10           10           17                                     
    Natural Death                                      2            5                         5                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Moribund Sacrifice                                                           1                                                  
    Terminal Sacrifice                                32           35           38           28                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (48)         (49)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Mesentery                                          (26)         (20)         (20)         (17)                                   
   Oral Mucosa                                        (1)                                    (2)                                    
      Gingival, Squamous Cell Carcinoma                1 (100%)                                                                     
   Stomach, Glandular                                 (50)         (47)         (49)         (49)                                   
      Adenoma                                                       1 (2%)                                                          
   Tongue                                             (2)                                    (1)                                    
      Squamous Cell Carcinoma                          1 (50%)                                                                      
      Squamous Cell Papilloma                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                    (50)         (48)         (49)         (49)                                   
      Pheochromocytoma Malignant                                    2 (4%)       1 (2%)                                             
      Pheochromocytoma Benign                          1 (2%)       1 (2%)       3 (6%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (47)         (49)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (49)         (49)         (50)                                   
      Pars Distalis, Adenoma                          34 (68%)     27 (55%)     29 (59%)     30 (60%)                               
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Carcinoma                                      1 (2%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (49)         (49)         (50)                                   
      C-Cell, Adenoma                                  5 (10%)      3 (6%)       2 (4%)       3 (6%)                                
      C-Cell, Carcinoma                                3 (6%)                    1 (2%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (49)         (50)                                   
      Adenoma                                          8 (17%)      2 (4%)       1 (2%)                                             
      Carcinoma                                        1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
   Ovary                                              (50)         (50)         (49)         (50)                                   
      Granulosa Cell Tumor Malignant                                1 (2%)                                                          
      Granulosa Cell Tumor Benign                                   2 (4%)                                                          
      Thecoma Malignant                                1 (2%)                                                                       
   Uterus                                             (50)         (49)         (49)         (50)                                   
      Polyp Stromal                                    6 (12%)      8 (16%)     14 (29%)     12 (24%)                               
      Sarcoma Stromal                                                                         1 (2%)                                
      Bilateral, Polyp Stromal                         1 (2%)                                                                       
      Endometrium, Carcinoma                                                     2 (4%)       1 (2%)                                
   Vagina                                             (1)                                    (2)                                    
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)         (50)                                   
   Lymph Node                                         (6)                       (4)          (2)                                    
   Lymph Node, Bronchial                              (2)          (10)         (7)          (5)                                    
      Carcinoma, Metastatic, Uterus                                              1 (14%)                                            
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (49)                                   
   Lymph Node, Mediastinal                            (45)         (46)         (49)         (44)                                   
   Spleen                                             (50)         (49)         (49)         (50)                                   
      Sarcoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Carcinoma                                        5 (10%)      3 (6%)       6 (12%)      3 (6%)                                
      Fibroadenoma                                    17 (34%)     14 (28%)     17 (35%)     18 (36%)                               
      Fibroadenoma, Multiple                           8 (16%)      8 (16%)      3 (6%)       5 (10%)                               
   Skin                                               (50)         (50)         (49)         (50)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Basal Cell Carcinoma                             1 (2%)                    1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                               1 (2%)       2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Neural Crest Tumor          1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Humerus, Osteosarcoma                                         1 (2%)       1 (2%)                                             
   Skeletal Muscle                                    (1)          (2)          (1)                                                 
      Carcinoma, Metastatic, Uterus                                              1 (100%)                                           
      Carcinoma, Metastatic, Zymbal's Gland                         1 (50%)                                                         
      Osteosarcoma, Metastatic, Bone                                1 (50%)                                                         
      Rhabdomyosarcoma                                 1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Uterus                                              1 (2%)       1 (2%)                                
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                                    1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                           1 (2%)                                                          
   Pleura                                             (20)         (25)         (25)         (28)                                   
      Carcinoma, Metastatic, Uterus                                              1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (46)         (49)         (50)                                   
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                                    1 (2%)                                                          
      Pelvis, Transitional Epithelium, Carcinoma                                              1 (2%)                                
   Urinary Bladder                                    (50)         (47)         (49)         (50)                                   
      Sarcoma, Metastatic, Vagina                      1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leukemia Mononuclear                            11 (22%)     15 (30%)     12 (24%)     14 (28%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      25 PPM       100 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          44          46          48                                       
     Total Primary Neoplasms                          114          96         103          95                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          41          44          44                                       
     Total Benign Neoplasms                            83          66          72          72                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          22          25          18                                       
     Total Malignant Neoplasms                         30          30          31          22                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4           2           2                                       
     Total Metastatic Neoplasm                          1           6           5           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                   1                                       
     Total Uncertain Neoplasms                          1                                   1                                       
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50           20                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           21           23           23            6                        
    Natural Death                                      5            6            3            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           23           23           20           14                        
  Other                                                                          1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           49           50           20                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (47)         (48)         (49)         (20)                      
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (47)         (45)         (46)         (47)         (20)                      
   Intestine Small, Ileum                             (46)         (45)         (46)         (48)         (20)                      
      Leiomyoma                                                                               1 (2%)                                
   Liver                                              (50)         (50)         (49)         (50)         (20)                      
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                    1 (2%)                                                          
   Mesentery                                          (16)         (19)         (20)         (13)         (10)                      
      Carcinoma, Metastatic, Urinary Bladder                        1 (5%)                                                          
      Schwannoma Malignant                                                                    1 (8%)                                
   Oral Mucosa                                                     (2)          (2)          (1)                                    
      Pharyngeal, Squamous Cell Carcinoma                                                     1 (100%)                              
      Pharyngeal, Squamous Cell Papilloma                           1 (50%)      2 (100%)                                           
   Pancreas                                           (50)         (50)         (49)         (50)         (20)                      
      Carcinoma                                                                  1 (2%)                                             
      Carcinoma, Metastatic, Kidney                                 1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (49)         (50)         (20)                      
      Sarcoma                                                                    1 (2%)                                             
      Schwannoma Malignant                                                                    1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (49)         (50)         (20)                      
   Tongue                                                          (1)          (2)          (1)                                    
      Squamous Cell Papilloma                                       1 (100%)     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)         (20)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                    (49)         (49)         (49)         (49)         (20)                      
      Pheochromocytoma Malignant                       2 (4%)                    2 (4%)       7 (14%)      3 (15%)                  
      Pheochromocytoma Benign                          7 (14%)      8 (16%)     10 (20%)      9 (18%)      4 (20%)                  
      Bilateral, Pheochromocytoma Benign                            1 (2%)       1 (2%)       1 (2%)       2 (10%)                  
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)         (20)                      
      Adenoma                                          3 (6%)       3 (6%)       3 (6%)       2 (4%)       1 (5%)                   
      Carcinoma                                        4 (8%)       1 (2%)                    4 (8%)                                
   Pituitary Gland                                    (50)         (50)         (49)         (49)         (20)                      
      Craniopharyngeal Duct, Craniopharyngioma                      1 (2%)                                                          
      Pars Distalis, Adenoma                          27 (54%)     33 (66%)     25 (51%)     25 (51%)      9 (45%)                  
      Pars Distalis, Carcinoma                                                   1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (49)         (49)         (20)                      
      C-Cell, Adenoma                                  7 (14%)      4 (8%)       4 (8%)       3 (6%)       2 (10%)                  
      C-Cell, Carcinoma                                             2 (4%)       1 (2%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (2)          (2)          (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)         (20)                      
   Preputial Gland                                    (50)         (49)         (49)         (50)         (20)                      
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Carcinoma                                                     1 (2%)       1 (2%)       3 (6%)       2 (10%)                  
   Prostate, NOS                                      (50)         (50)         (49)         (50)         (20)                      
      Carcinoma, Metastatic, Urinary Bladder                        1 (2%)                                                          
      Ventral, Adenoma                                              1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (49)         (50)         (20)                      
      Carcinoma, Metastatic, Kidney                                 1 (2%)                                                          
   Testes                                             (50)         (50)         (49)         (50)         (20)                      
      Bilateral, Interstitial Cell, Adenoma           34 (68%)     31 (62%)     39 (80%)     29 (58%)     16 (80%)                  
      Interstitial Cell, Adenoma                       6 (12%)     10 (20%)      8 (16%)     15 (30%)      4 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)         (20)                      
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (8)          (10)         (14)         (11)         (1)                       
      Deep Cervical, Carcinoma, Metastatic, Kidney                  1 (10%)                                                         
      Pancreatic, Histiocytic Sarcoma                               1 (10%)                                                         
   Lymph Node, Bronchial                              (7)          (8)          (18)         (17)         (7)                       
   Lymph Node, Mandibular                             (3)          (2)                       (3)          (1)                       
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (49)         (20)                      
      Carcinoma, Metastatic, Urinary Bladder                        1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                    1 (2%)                                                          
   Lymph Node, Mediastinal                            (48)         (45)         (44)         (48)         (16)                      
      Carcinoma, Metastatic, Kidney                                 1 (2%)                                                          
   Spleen                                             (50)         (50)         (49)         (50)         (20)                      
      Capsule, Carcinoma, Metastatic, Kidney                        1 (2%)                                                          
   Thymus                                             (50)         (48)         (47)         (50)         (20)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)         (20)                      
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)       1 (2%)                    1 (2%)                                
      Fibroadenoma                                     2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
   Skin                                               (50)         (50)         (49)         (50)         (20)                      
      Basal Cell Adenoma                               1 (2%)       2 (4%)                                 1 (5%)                   
      Keratoacanthoma                                  1 (2%)       2 (4%)                    1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
      Trichoepithelioma                                                                       1 (2%)                                
      Pinna, Neural Crest Tumor                        1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)       5 (10%)      3 (6%)       2 (4%)       1 (5%)                   
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                                 1 (2%)                                
      Subcutaneous Tissue, Lipoma                                   1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Benign                                     1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)         (20)                      
      Osteosarcoma                                                                            1 (2%)                                
      Cranium, Osteoma                                                                        1 (2%)                                
      Cranium, Squamous Cell Carcinoma, Metastatic,                                                                                 
           Oral Mucosa                                                                        1 (2%)                                
   Skeletal Muscle                                                 (1)                       (5)                                    
      Histiocytic Sarcoma                                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)         (20)                      
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)         (20)                      
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (2%)                    1 (5%)                   
      Carcinoma, Metastatic, Kidney                                 1 (2%)                    1 (2%)                                
      Carcinoma, Metastatic, Urinary Bladder                        1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Liver                        1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                    1 (2%)                                                          
      Neural Crest Tumor, Metastatic, Skin                                       1 (2%)                                             
   Pleura                                             (9)          (8)          (8)          (5)          (6)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (2)          (2)          (2)          (1)                       
      Carcinoma, Metastatic, Pituitary Gland                        1 (50%)                                                         
   Harderian Gland                                    (1)                                    (2)                                    
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                              1 (50%)                               
   Zymbal's Gland                                                               (2)          (2)                                    
      Carcinoma                                                                  2 (100%)     2 (100%)                              
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                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)         (20)                      
      Histiocytic Sarcoma, Metastatic, Liver                        1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                    1 (2%)                                                          
      Bilateral, Renal Tubule, Carcinoma                            1 (2%)                                                          
      Cortex, Renal Tubule, Adenoma                    1 (2%)       2 (4%)       6 (12%)      9 (18%)      3 (15%)                  
      Cortex, Renal Tubule, Adenoma, Multiple                                                              1 (5%)                   
      Cortex, Renal Tubule, Carcinoma                                            1 (2%)       4 (8%)       1 (5%)                   
      Pelvis, Transitional Epithelium, Carcinoma       1 (2%)                                                                       
      Pelvis, Transitional Epithelium, Papilloma                    1 (2%)                                                          
      Renal Tubule, Adenoma                                                                                1 (5%)                   
   Urinary Bladder                                    (50)         (49)         (49)         (49)         (20)                      
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
      Transitional Epithelium, Papilloma                                                      1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(49)        *(50)        *(20)                      
      Histiocytic Sarcoma                                           2 (4%)                                                          
      Leukemia Mononuclear                            19 (38%)     23 (46%)     27 (55%)     25 (50%)     10 (50%)                  
      Lymphoma Malignant                                                         1 (2%)       1 (2%)                                
      Mesothelioma Malignant                           1 (2%)       2 (4%)       2 (4%)       5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 93026-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              DECALIN                                          Date: 08/24/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:30:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      25 PPM       50 PPM       100 PPM      400 PPM                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          49          50          20                           
     Total Primary Neoplasms                          127         145         154         161          62                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          49          49          48          20                           
     Total Benign Neoplasms                            94         111         111         102          45                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          28          32          42          13                           
     Total Malignant Neoplasms                         32          34          42          59          17                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          5           2           4                                       
     Total Metastatic Neoplasm                                     18           2          16                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       1                                                   
     Total Uncertain Neoplasms                          1                       1                                                   
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
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