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TDMS Study 93026-07 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 08/28/01       
EXPERIMENT: 93026 TEST: 07                                                                                     TIME: 09:20:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 91-17-8         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    CONTROL                                                                       
                                       INCLUDE 003    25 PPM                                                                        
                                       INCLUDE 005    50 PPM                                                                        
                                       INCLUDE 006    100 PPM                                                                       
                                       INCLUDE 008    400 PPM                                                                       
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 08/28/01       
EXPERIMENT: 93026 TEST: 07                                                                                     TIME: 09:20:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 91-17-8         
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Medulla                                                                    
                                                 Clitoral/Preputial Gland                                                           
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Lung                                                                               
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Prostate, NOS                                                                      
                                                 Salivary Glands                                                                    
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 08/28/01       
EXPERIMENT: 93026 TEST: 07                                                                                     TIME: 09:20:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 91-17-8         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     DECALIN                                                                                      
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Malignant                                                                   
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS                                            
Clitoral/Preputial Gland               Carcinoma                                                                                    
Kidney: Renal Tubule                   Adenoma                                                                                      
                                       Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
Testes                                 Adenoma                                                                                      
All Organs                             Malignant Tumors                                                                             
===============================================================                                                                     
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                      DECALIN              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/49 (14%)       9/49 (18%)       11/49 (22%)      10/49 (20%)      6/20 (30%)                       | 
|POLY-3 RATE (b)    |        7/41.92          9/40.83          11/43.99         10/40.30         6/18.88                          | 
|POLY-3 PERCENT (g) |        16.7%            22.0%            25.0%            24.8%            31.8%                            | 
|TERMINAL (d)       |        4/28 (14%)       8/23 (35%)       6/23 (26%)       6/20 (30%)       4/14 (29%)                       | 
|FIRST INCIDENCE    |        561              589              602              600              708                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.321          P=0.258          P=0.156          P=0.139          P=0.245                          | 
|POLY 3             |        P=0.173          P=0.368          P=0.247          P=0.261          P=0.155                          | 
|POLY 1.5           |        P=0.151          P=0.379          P=0.238          P=0.278          P=0.137                          | 
|POLY 6             |        P=0.215          P=0.351          P=0.250          P=0.237          P=0.185                          | 
|LOGISTIC REGRESSION|        P=0.206          P=0.363          P=0.234          P=0.245          P=0.173                          | 
|COCH-ARM / FISHERS |        P=0.129          P=0.393          P=0.217          P=0.297          P=0.121                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/49 (4%)        0/49 (0%)        2/49 (4%)        7/49 (14%)       3/20 (15%)                       | 
|POLY-3 RATE (b)    |        2/41.35          0/40.35          2/43.10          7/40.53          3/18.75                          | 
|POLY-3 PERCENT (g) |        4.8%             0.0%             4.6%             17.3%            16.0%                            | 
|TERMINAL (d)       |        1/28 (4%)        0/23 (0%)        0/23 (0%)        3/20 (15%)       2/14 (14%)                       | 
|FIRST INCIDENCE    |        706              ---              638              506              716                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.076          P=0.265N         P=0.673          P=0.044 *        P=0.227                          | 
|POLY 3             |        P=0.034 *        P=0.242N         P=0.679N         P=0.072          P=0.166                          | 
|POLY 1.5           |        P=0.028 *        P=0.240N         P=0.683N         P=0.075          P=0.154                          | 
|POLY 6             |        P=0.045 *        P=0.246N         P=0.680N         P=0.066          P=0.185                          | 
|LOGISTIC REGRESSION|        P=0.030 *        P=0.248N         P=0.692N         P=0.074          P=0.208                          | 
|COCH-ARM / FISHERS |        P=0.025 *        P=0.247N         P=0.691N         P=0.080          P=0.142                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/49 (16%)       9/49 (18%)       13/49 (27%)      16/49 (33%)      8/20 (40%)                       | 
|POLY-3 RATE (b)    |        8/41.92          9/40.83          13/44.46         16/41.43         8/18.95                          | 
|POLY-3 PERCENT (g) |        19.1%            22.0%            29.2%            38.6%            42.2%                            | 
|TERMINAL (d)       |        5/28 (18%)       8/23 (35%)       6/23 (26%)       8/20 (40%)       5/14 (36%)                       | 
|FIRST INCIDENCE    |        561              589              602              506              708                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.134          P=0.347          P=0.117          P=0.014 *        P=0.115                          | 
|POLY 3             |        P=0.038 *        P=0.476          P=0.196          P=0.038 *        P=0.049 *                        | 
|POLY 1.5           |        P=0.029 *        P=0.487          P=0.184          P=0.042 *        P=0.041 *                        | 
|POLY 6             |        P=0.056          P=0.458          P=0.205          P=0.032 *        P=0.065                          | 
|LOGISTIC REGRESSION|        P=0.044 *        P=0.468          P=0.176          P=0.036 *        P=0.067                          | 
|COCH-ARM / FISHERS |        P=0.023 *        P=0.500          P=0.162          P=0.049 *        P=0.039 *                        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/42.09          0/40.74          0/42.63          2/40.40          0/18.68                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.0%             0.0%                             | 
|TERMINAL (d)       |        0/28 (0%)        0/23 (0%)        0/23 (0%)        1/20 (5%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              688              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.758          (e)              (e)              P=0.184          (e)                              | 
|POLY 3             |        P=0.795          (e)              (e)              P=0.228          (e)                              | 
|POLY 1.5           |        P=0.776          (e)              (e)              P=0.232          (e)                              | 
|POLY 6             |        P=0.819          (e)              (e)              P=0.220          (e)                              | 
|LOGISTIC REGRESSION|        P=0.756          (e)              (e)              P=0.218          (e)                              | 
|COCH-ARM / FISHERS |        P=0.749          (e)              (e)              P=0.247          (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        1/49 (2%)        1/49 (2%)        3/50 (6%)        2/20 (10%)                       | 
|POLY-3 RATE (b)    |        0/42.09          1/40.12          1/42.97          3/41.09          2/18.68                          | 
|POLY-3 PERCENT (g) |        0.0%             2.5%             2.3%             7.3%             10.7%                            | 
|TERMINAL (d)       |        0/28 (0%)        0/23 (0%)        0/23 (0%)        2/20 (10%)       2/14 (14%)                       | 
|FIRST INCIDENCE    |        ---              638              638              379              733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.082          P=0.495          P=0.510          P=0.085          P=0.103                          | 
|POLY 3             |        P=0.053          P=0.490          P=0.504          P=0.114          P=0.075                          | 
|POLY 1.5           |        P=0.047 *        P=0.493          P=0.502          P=0.117          P=0.070                          | 
|POLY 6             |        P=0.062          P=0.488          P=0.504          P=0.108          P=0.082                          | 
|LOGISTIC REGRESSION|        P=0.029 *        P=0.507          P=0.441          P=0.131          P=0.103                          | 
|COCH-ARM / FISHERS |        P=0.042 *        P=0.495          P=0.495          P=0.121          P=0.079                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/49 (4%)        2/49 (4%)        3/50 (6%)        2/20 (10%)                       | 
|POLY-3 RATE (b)    |        0/42.09          2/40.12          2/42.97          3/41.09          2/18.68                          | 
|POLY-3 PERCENT (g) |        0.0%             5.0%             4.7%             7.3%             10.7%                            | 
|TERMINAL (d)       |        0/28 (0%)        1/23 (4%)        1/23 (4%)        2/20 (10%)       2/14 (14%)                       | 
|FIRST INCIDENCE    |        ---              638              638              379              733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.170          P=0.216          P=0.223          P=0.085          P=0.103                          | 
|POLY 3             |        P=0.122          P=0.226          P=0.241          P=0.114          P=0.075                          | 
|POLY 1.5           |        P=0.111          P=0.229          P=0.239          P=0.117          P=0.070                          | 
|POLY 6             |        P=0.140          P=0.223          P=0.241          P=0.108          P=0.082                          | 
|LOGISTIC REGRESSION|        P=0.087          P=0.230          P=0.228          P=0.131          P=0.103                          | 
|COCH-ARM / FISHERS |        P=0.099          P=0.242          P=0.242          P=0.121          P=0.079                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        3/49 (6%)        2/50 (4%)        1/20 (5%)                        | 
|POLY-3 RATE (b)    |        3/42.52          3/40.88          3/42.90          2/40.71          1/18.68                          | 
|POLY-3 PERCENT (g) |        7.1%             7.3%             7.0%             4.9%             5.4%                             | 
|TERMINAL (d)       |        1/28 (4%)        1/23 (4%)        1/23 (4%)        0/20 (0%)        1/14 (7%)                        | 
|FIRST INCIDENCE    |        658              708              680              649              733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.445N         P=0.609          P=0.628          P=0.574N         P=0.557N                         | 
|POLY 3             |        P=0.535N         P=0.645          P=0.659N         P=0.520N         P=0.624N                         | 
|POLY 1.5           |        P=0.549N         P=0.652          P=0.661N         P=0.510N         P=0.638N                         | 
|POLY 6             |        P=0.512N         P=0.634          P=0.663N         P=0.536N         P=0.603N                         | 
|LOGISTIC REGRESSION|        P=0.521N         P=0.644          P=0.661N         P=0.505N         P=0.634N                         | 
|COCH-ARM / FISHERS |        P=0.565N         P=0.661N         P=0.651          P=0.500N         P=0.749                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/50 (8%)        1/50 (2%)        0/49 (0%)        4/50 (8%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        4/43.31          1/40.74          0/42.63          4/40.40          0/18.68                          | 
|POLY-3 PERCENT (g) |        9.2%             2.5%             0.0%             9.9%             0.0%                             | 
|TERMINAL (d)       |        2/28 (7%)        1/23 (4%)        0/23 (0%)        3/20 (15%)       0/14 (0%)                        | 
|FIRST INCIDENCE    |        421              733 (T)          ---              688              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.301N         P=0.224N         P=0.077N         P=0.509          P=0.203N                         | 
|POLY 3             |        P=0.326N         P=0.197N         P=0.062N         P=0.605          P=0.209N                         | 
|POLY 1.5           |        P=0.343N         P=0.190N         P=0.062N         P=0.622          P=0.220N                         | 
|POLY 6             |        P=0.298N         P=0.207N         P=0.063N         P=0.580          P=0.194N                         | 
|LOGISTIC REGRESSION|        P=0.368N         P=0.166N         P=0.099N         P=0.640N         P=0.280N                         | 
|COCH-ARM / FISHERS |        P=0.364N         P=0.181N         P=0.061N         P=0.643N         P=0.251N                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/50 (14%)       4/50 (8%)        3/49 (6%)        6/50 (12%)       1/20 (5%)                        | 
|POLY-3 RATE (b)    |        7/43.74          4/40.88          3/42.90          6/40.88          1/18.68                          | 
|POLY-3 PERCENT (g) |        16.0%            9.8%             7.0%             14.7%            5.4%                             | 
|TERMINAL (d)       |        3/28 (11%)       2/23 (9%)        1/23 (4%)        3/20 (15%)       1/14 (7%)                        | 
|FIRST INCIDENCE    |        421              708              680              649              733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.236N         P=0.339N         P=0.200N         P=0.573          P=0.192N                         | 
|POLY 3             |        P=0.292N         P=0.299N         P=0.163N         P=0.553N         P=0.227N                         | 
|POLY 1.5           |        P=0.313N         P=0.284N         P=0.163N         P=0.530N         P=0.241N                         | 
|POLY 6             |        P=0.260N         P=0.321N         P=0.170N         P=0.586N         P=0.207N                         | 
|LOGISTIC REGRESSION|        P=0.315N         P=0.262N         P=0.193N         P=0.499N         P=0.298N                         | 
|COCH-ARM / FISHERS |        P=0.335N         P=0.262N         P=0.167N         P=0.500N         P=0.268N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        6/49 (12%)       9/50 (18%)       5/20 (25%)                       | 
|POLY-3 RATE (b)    |        1/42.09          2/41.09          6/42.90          9/41.34          5/18.75                          | 
|POLY-3 PERCENT (g) |        2.4%             4.9%             14.0%            21.8%            26.7%                            | 
|TERMINAL (d)       |        1/28 (4%)        0/23 (0%)        4/23 (17%)       5/20 (25%)       4/14 (29%)                       | 
|FIRST INCIDENCE    |        733 (T)          644              680              617              716                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.024 *        P=0.453          P=0.038 *        P=0.004 **       P=0.012 *                        | 
|POLY 3             |        P=0.005 **       P=0.492          P=0.058          P=0.007 **       P=0.004 **                       | 
|POLY 1.5           |        P=0.004 **       P=0.495          P=0.057          P=0.007 **       P=0.003 **                       | 
|POLY 6             |        P=0.007 **       P=0.488          P=0.057          P=0.006 **       P=0.005 **                       | 
|LOGISTIC REGRESSION|        P=0.009 **       P=0.489          P=0.051          P=0.007 **       P=0.012 *                        | 
|COCH-ARM / FISHERS |        P=0.003 **       P=0.500          P=0.053          P=0.008 **       P=0.006 **                       | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/49 (2%)        4/50 (8%)        1/20 (5%)                        | 
|POLY-3 RATE (b)    |        0/42.09          1/40.74          1/42.78          4/40.81          1/18.78                          | 
|POLY-3 PERCENT (g) |        0.0%             2.5%             2.3%             9.8%             5.3%                             | 
|TERMINAL (d)       |        0/28 (0%)        1/23 (4%)        0/23 (0%)        2/20 (10%)       0/14 (0%)                        | 
|FIRST INCIDENCE    |        ---              733 (T)          694              617              708                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.358          P=0.461          P=0.494          P=0.044 *        P=0.393                          | 
|POLY 3             |        P=0.303          P=0.493          P=0.503          P=0.056          P=0.334                          | 
|POLY 1.5           |        P=0.278          P=0.496          P=0.501          P=0.058          P=0.326                          | 
|POLY 6             |        P=0.343          P=0.490          P=0.503          P=0.052          P=0.347                          | 
|LOGISTIC REGRESSION|        P=0.277          P=0.461          P=0.498          P=0.059          P=0.332                          | 
|COCH-ARM / FISHERS |        P=0.249          P=0.500          P=0.495          P=0.059          P=0.286                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        7/49 (14%)       12/50 (24%)      6/20 (30%)                       | 
|POLY-3 RATE (b)    |        1/42.09          3/41.09          7/43.05          12/41.51         6/18.85                          | 
|POLY-3 PERCENT (g) |        2.4%             7.3%             16.3%            28.9%            31.8%                            | 
|TERMINAL (d)       |        1/28 (4%)        1/23 (4%)        4/23 (17%)       7/20 (35%)       4/14 (29%)                       | 
|FIRST INCIDENCE    |        733 (T)          644              680              617              708                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.015 *        P=0.255          P=0.022 *        P<0.001 **       P=0.005 **                       | 
|POLY 3             |        P=0.002 **       P=0.296          P=0.031 *        P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.300          P=0.031 *        P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P=0.003 **       P=0.291          P=0.031 *        P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P=0.004 **       P=0.289          P=0.029 *        P<0.001 **       P=0.004 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.309          P=0.028 *        P<0.001 **       P=0.002 **                       | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        2/49 (4%)        1/50 (2%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        1/42.29          1/40.74          2/42.78          1/40.22          0/18.68                          | 
|POLY-3 PERCENT (g) |        2.4%             2.5%             4.7%             2.5%             0.0%                             | 
|TERMINAL (d)       |        0/28 (0%)        1/23 (4%)        1/23 (4%)        1/20 (5%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        680              733 (T)          694              733 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.416N         P=0.729          P=0.474          P=0.706          P=0.627N                         | 
|POLY 3             |        P=0.466N         P=0.753          P=0.504          P=0.750          P=0.665N                         | 
|POLY 1.5           |        P=0.477N         P=0.756          P=0.501          P=0.755          P=0.673N                         | 
|POLY 6             |        P=0.448N         P=0.748          P=0.502          P=0.741          P=0.654N                         | 
|LOGISTIC REGRESSION|        P=0.444N         P=0.754          P=0.502          P=0.748          P=0.696N                         | 
|COCH-ARM / FISHERS |        P=0.490N         P=0.753N         P=0.492          P=0.753N         P=0.714N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        3/49 (6%)        1/50 (2%)        1/20 (5%)                        | 
|POLY-3 RATE (b)    |        2/42.29          1/40.74          3/42.93          1/40.22          1/18.68                          | 
|POLY-3 PERCENT (g) |        4.7%             2.5%             7.0%             2.5%             5.4%                             | 
|TERMINAL (d)       |        1/28 (4%)        1/23 (4%)        1/23 (4%)        1/20 (5%)        1/14 (7%)                        | 
|FIRST INCIDENCE    |        680              733 (T)          694              733 (T)          733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.643N         P=0.556N         P=0.459          P=0.595N         P=0.726N                         | 
|POLY 3             |        P=0.646          P=0.513N         P=0.507          P=0.517N         P=0.706                          | 
|POLY 1.5           |        P=0.630          P=0.507N         P=0.503          P=0.509N         P=0.693                          | 
|POLY 6             |        P=0.671          P=0.522N         P=0.506          P=0.532N         P=0.724                          | 
|LOGISTIC REGRESSION|        P=0.664          P=0.520N         P=0.504          P=0.537N         P=0.719                          | 
|COCH-ARM / FISHERS |        P=0.611          P=0.500N         P=0.490          P=0.500N         P=0.642                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)        1/50 (2%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        2/42.09          1/40.74          0/42.63          1/40.40          0/18.68                          | 
|POLY-3 PERCENT (g) |        4.8%             2.5%             0.0%             2.5%             0.0%                             | 
|TERMINAL (d)       |        2/28 (7%)        1/23 (4%)        0/23 (0%)        0/20 (0%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        733 (T)          733 (T)          ---              687              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.386N         P=0.569N         P=0.282N         P=0.588N         P=0.400N                         | 
|POLY 3             |        P=0.434N         P=0.511N         P=0.234N         P=0.514N         P=0.428N                         | 
|POLY 1.5           |        P=0.440N         P=0.507N         P=0.236N         P=0.508N         P=0.440N                         | 
|POLY 6             |        P=0.423N         P=0.518N         P=0.235N         P=0.526N         P=0.410N                         | 
|LOGISTIC REGRESSION|        P=0.397N         P=0.569N         (e)              P=0.542N         (e)                              | 
|COCH-ARM / FISHERS |        P=0.445N         P=0.500N         P=0.247N         P=0.500N         P=0.507N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        3/50 (6%)        1/50 (2%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        2/42.11          1/40.74          3/42.88          1/40.30          0/18.68                          | 
|POLY-3 PERCENT (g) |        4.8%             2.5%             7.0%             2.5%             0.0%                             | 
|TERMINAL (d)       |        1/28 (4%)        1/23 (4%)        2/23 (9%)        0/20 (0%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        728              733 (T)          666              715              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.295N         P=0.572N         P=0.429          P=0.602N         P=0.406N                         | 
|POLY 3             |        P=0.325N         P=0.512N         P=0.508          P=0.515N         P=0.428N                         | 
|POLY 1.5           |        P=0.337N         P=0.507N         P=0.503          P=0.508N         P=0.440N                         | 
|POLY 6             |        P=0.306N         P=0.519N         P=0.508          P=0.528N         P=0.411N                         | 
|LOGISTIC REGRESSION|        P=0.300N         P=0.543N         P=0.495          P=0.562N         P=0.390N                         | 
|COCH-ARM / FISHERS |        P=0.351N         P=0.500N         P=0.500          P=0.500N         P=0.507N                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/50 (6%)        1/50 (2%)        3/50 (6%)        1/50 (2%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        3/42.11          1/40.74          3/42.88          1/40.30          0/18.68                          | 
|POLY-3 PERCENT (g) |        7.1%             2.5%             7.0%             2.5%             0.0%                             | 
|TERMINAL (d)       |        2/28 (7%)        1/23 (4%)        2/23 (9%)        0/20 (0%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        728              733 (T)          666              715              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.226N         P=0.382N         P=0.584          P=0.422N         P=0.271N                         | 
|POLY 3             |        P=0.248N         P=0.317N         P=0.655N         P=0.321N         P=0.291N                         | 
|POLY 1.5           |        P=0.259N         P=0.312N         P=0.659N         P=0.313N         P=0.304N                         | 
|POLY 6             |        P=0.231N         P=0.323N         P=0.656N         P=0.333N         P=0.272N                         | 
|LOGISTIC REGRESSION|        P=0.225N         P=0.350N         P=0.655          P=0.375N         P=0.256N                         | 
|COCH-ARM / FISHERS |        P=0.270N         P=0.309N         P=0.661N         P=0.309N         P=0.358N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/50 (8%)        2/50 (4%)        3/50 (6%)        2/50 (4%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        4/42.11          2/40.74          3/42.88          2/40.47          0/18.68                          | 
|POLY-3 PERCENT (g) |        9.5%             4.9%             7.0%             4.9%             0.0%                             | 
|TERMINAL (d)       |        3/28 (11%)       2/23 (9%)        2/23 (9%)        0/20 (0%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        728              733 (T)          666              687              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.163N         P=0.433N         P=0.592N         P=0.471N         P=0.186N                         | 
|POLY 3             |        P=0.181N         P=0.352N         P=0.490N         P=0.355N         P=0.201N                         | 
|POLY 1.5           |        P=0.193N         P=0.346N         P=0.496N         P=0.347N         P=0.215N                         | 
|POLY 6             |        P=0.163N         P=0.360N         P=0.490N         P=0.369N         P=0.183N                         | 
|LOGISTIC REGRESSION|        P=0.164N         P=0.401N         P=0.517N         P=0.403N         P=0.172N                         | 
|COCH-ARM / FISHERS |        P=0.206N         P=0.339N         P=0.500N         P=0.339N         P=0.251N                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Papilloma Squamous or Papilloma                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        3/50 (6%)        0/50 (0%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/42.09          2/40.91          3/42.63          0/40.22          0/18.68                          | 
|POLY-3 PERCENT (g) |        0.0%             4.9%             7.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/28 (0%)        1/23 (4%)        3/23 (13%)       0/20 (0%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        ---              688              733 (T)          ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.382N         P=0.212          P=0.087          (e)              (e)                              | 
|POLY 3             |        P=0.430N         P=0.230          P=0.120          (e)              (e)                              | 
|POLY 1.5           |        P=0.439N         P=0.233          P=0.119          (e)              (e)                              | 
|POLY 6             |        P=0.416N         P=0.227          P=0.119          (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.389N         P=0.227          P=0.087          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.449N         P=0.247          P=0.121          (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        3/50 (6%)        1/50 (2%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/42.09          2/40.91          3/42.63          1/40.43          0/18.68                          | 
|POLY-3 PERCENT (g) |        0.0%             4.9%             7.0%             2.5%             0.0%                             | 
|TERMINAL (d)       |        0/28 (0%)        1/23 (4%)        3/23 (13%)       0/20 (0%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        ---              688              733 (T)          679              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.409N         P=0.212          P=0.087          P=0.477          (e)                              | 
|POLY 3             |        P=0.459N         P=0.230          P=0.120          P=0.492          (e)                              | 
|POLY 1.5           |        P=0.473N         P=0.233          P=0.119          P=0.496          (e)                              | 
|POLY 6             |        P=0.437N         P=0.227          P=0.119          P=0.486          (e)                              | 
|LOGISTIC REGRESSION|        P=0.434N         P=0.227          P=0.087          P=0.500          (e)                              | 
|COCH-ARM / FISHERS |        P=0.490N         P=0.247          P=0.121          P=0.500          (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa                                                                                                                      | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        2/50 (4%)        0/50 (0%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/42.09          1/40.91          2/42.63          0/40.22          0/18.68                          | 
|POLY-3 PERCENT (g) |        0.0%             2.4%             4.7%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/28 (0%)        0/23 (0%)        2/23 (9%)        0/20 (0%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        ---              688              733 (T)          ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.526N         P=0.488          P=0.195          (e)              (e)                              | 
|POLY 3             |        P=0.587N         P=0.494          P=0.240          (e)              (e)                              | 
|POLY 1.5           |        P=0.593N         P=0.497          P=0.238          (e)              (e)                              | 
|POLY 6             |        P=0.577N         P=0.491          P=0.238          (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.549N         P=0.498          P=0.195          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.599N         P=0.500          P=0.247          (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/50 (54%)      33/50 (66%)      25/49 (51%)      25/49 (51%)      9/20 (45%)                       | 
|POLY-3 RATE (b)    |        27/46.10         33/45.82         25/45.02         25/44.21         9/19.11                          | 
|POLY-3 PERCENT (g) |        58.6%            72.0%            55.5%            56.5%            47.1%                            | 
|TERMINAL (d)       |        14/28 (50%)      14/23 (61%)      14/23 (61%)      8/19 (42%)       5/14 (36%)                       | 
|FIRST INCIDENCE    |        561              509              574              506              694                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.061N         P=0.097          P=0.513          P=0.340          P=0.152N                         | 
|POLY 3             |        P=0.121N         P=0.120          P=0.467N         P=0.508N         P=0.280N                         | 
|POLY 1.5           |        P=0.146N         P=0.131          P=0.452N         P=0.488N         P=0.306N                         | 
|POLY 6             |        P=0.087N         P=0.109          P=0.521N         P=0.536N         P=0.243N                         | 
|LOGISTIC REGRESSION|        P=0.137N         P=0.135          P=0.415N         P=0.482N         P=0.297N                         | 
|COCH-ARM / FISHERS |        P=0.179N         P=0.154          P=0.462N         P=0.462N         P=0.339N                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/50 (54%)      33/50 (66%)      26/49 (53%)      26/49 (53%)      9/20 (45%)                       | 
|POLY-3 RATE (b)    |        27/46.10         33/45.82         26/45.42         26/44.21         9/19.11                          | 
|POLY-3 PERCENT (g) |        58.6%            72.0%            57.2%            58.8%            47.1%                            | 
|TERMINAL (d)       |        14/28 (50%)      14/23 (61%)      14/23 (61%)      9/19 (47%)       5/14 (36%)                       | 
|FIRST INCIDENCE    |        561              509              574              506              694                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.060N         P=0.097          P=0.450          P=0.275          P=0.152N                         | 
|POLY 3             |        P=0.121N         P=0.120          P=0.534N         P=0.577          P=0.280N                         | 
|POLY 1.5           |        P=0.146N         P=0.131          P=0.525N         P=0.573N         P=0.306N                         | 
|POLY 6             |        P=0.087N         P=0.109          P=0.576N         P=0.552          P=0.243N                         | 
|LOGISTIC REGRESSION|        P=0.137N         P=0.135          P=0.505N         P=0.568N         P=0.297N                         | 
|COCH-ARM / FISHERS |        P=0.177N         P=0.154          P=0.543N         P=0.543N         P=0.339N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        0/50 (0%)        0/50 (0%)        1/20 (5%)                        | 
|POLY-3 RATE (b)    |        1/42.50          2/40.97          0/42.63          0/40.22          1/18.68                          | 
|POLY-3 PERCENT (g) |        2.4%             4.9%             0.0%             0.0%             5.4%                             | 
|TERMINAL (d)       |        0/28 (0%)        1/23 (4%)        0/23 (0%)        0/20 (0%)        1/14 (7%)                        | 
|FIRST INCIDENCE    |        614              670              ---              ---              733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.563          P=0.466          P=0.491N         P=0.500N         P=0.587                          | 
|POLY 3             |        P=0.519          P=0.487          P=0.499N         P=0.511N         P=0.569                          | 
|POLY 1.5           |        P=0.514          P=0.493          P=0.500N         P=0.506N         P=0.558                          | 
|POLY 6             |        P=0.529          P=0.480          P=0.502N         P=0.520N         P=0.585                          | 
|LOGISTIC REGRESSION|        P=0.514          P=0.503          P=0.482N         P=0.485N         P=0.527                          | 
|COCH-ARM / FISHERS |        P=0.508          P=0.500          P=0.500N         P=0.500N         P=0.493                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           | 
|     Trichoepithelioma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        0/50 (0%)        1/50 (2%)        1/20 (5%)                        | 
|POLY-3 RATE (b)    |        1/42.50          2/40.97          0/42.63          1/40.22          1/18.68                          | 
|POLY-3 PERCENT (g) |        2.4%             4.9%             0.0%             2.5%             5.4%                             | 
|TERMINAL (d)       |        0/28 (0%)        1/23 (4%)        0/23 (0%)        1/20 (5%)        1/14 (7%)                        | 
|FIRST INCIDENCE    |        614              670              ---              733 (T)          733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.536          P=0.466          P=0.491N         P=0.724          P=0.587                          | 
|POLY 3             |        P=0.492          P=0.487          P=0.499N         P=0.749          P=0.569                          | 
|POLY 1.5           |        P=0.481          P=0.493          P=0.500N         P=0.754          P=0.558                          | 
|POLY 6             |        P=0.510          P=0.480          P=0.502N         P=0.739          P=0.585                          | 
|LOGISTIC REGRESSION|        P=0.486          P=0.503          P=0.482N         P=0.761N         P=0.527                          | 
|COCH-ARM / FISHERS |        P=0.468          P=0.500          P=0.500N         P=0.753N         P=0.493                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        0/50 (0%)        1/50 (2%)        1/20 (5%)                        | 
|POLY-3 RATE (b)    |        1/42.50          2/40.97          0/42.63          1/40.22          1/18.68                          | 
|POLY-3 PERCENT (g) |        2.4%             4.9%             0.0%             2.5%             5.4%                             | 
|TERMINAL (d)       |        0/28 (0%)        1/23 (4%)        0/23 (0%)        1/20 (5%)        1/14 (7%)                        | 
|FIRST INCIDENCE    |        614              670              ---              733 (T)          733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.536          P=0.466          P=0.491N         P=0.724          P=0.587                          | 
|POLY 3             |        P=0.492          P=0.487          P=0.499N         P=0.749          P=0.569                          | 
|POLY 1.5           |        P=0.481          P=0.493          P=0.500N         P=0.754          P=0.558                          | 
|POLY 6             |        P=0.510          P=0.480          P=0.502N         P=0.739          P=0.585                          | 
|LOGISTIC REGRESSION|        P=0.486          P=0.503          P=0.482N         P=0.761N         P=0.527                          | 
|COCH-ARM / FISHERS |        P=0.468          P=0.500          P=0.500N         P=0.753N         P=0.493                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        1/50 (2%)        2/50 (4%)        1/20 (5%)                        | 
|POLY-3 RATE (b)    |        3/42.70          3/41.61          1/42.63          2/40.22          1/18.68                          | 
|POLY-3 PERCENT (g) |        7.0%             7.2%             2.4%             5.0%             5.4%                             | 
|TERMINAL (d)       |        1/28 (4%)        1/23 (4%)        1/23 (4%)        2/20 (10%)       1/14 (7%)                        | 
|FIRST INCIDENCE    |        614              525              733 (T)          733 (T)          733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.531N         P=0.615          P=0.338N         P=0.604N         P=0.575N                         | 
|POLY 3             |        P=0.612N         P=0.651          P=0.305N         P=0.527N         P=0.625N                         | 
|POLY 1.5           |        P=0.621N         P=0.656          P=0.306N         P=0.514N         P=0.639N                         | 
|POLY 6             |        P=0.594N         P=0.643          P=0.311N         P=0.550N         P=0.605N                         | 
|LOGISTIC REGRESSION|        P=0.622N         P=0.652N         P=0.305N         P=0.520N         P=0.663N                         | 
|COCH-ARM / FISHERS |        P=0.633N         P=0.661N         P=0.309N         P=0.500N         P=0.749                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        5/50 (10%)       3/50 (6%)        2/50 (4%)        1/20 (5%)                        | 
|POLY-3 RATE (b)    |        2/42.09          5/41.68          3/42.63          2/40.90          1/18.68                          | 
|POLY-3 PERCENT (g) |        4.8%             12.0%            7.0%             4.9%             5.4%                             | 
|TERMINAL (d)       |        2/28 (7%)        2/23 (9%)        3/23 (13%)       1/20 (5%)        1/14 (7%)                        | 
|FIRST INCIDENCE    |        733 (T)          532              733 (T)          506              733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.428N         P=0.174          P=0.409          P=0.601          P=0.735                          | 
|POLY 3             |        P=0.503N         P=0.211          P=0.506          P=0.684          P=0.707                          | 
|POLY 1.5           |        P=0.519N         P=0.213          P=0.502          P=0.689          P=0.694                          | 
|POLY 6             |        P=0.477N         P=0.208          P=0.503          P=0.674          P=0.726                          | 
|LOGISTIC REGRESSION|        P=0.515N         P=0.209          P=0.409          P=0.694N         P=0.735                          | 
|COCH-ARM / FISHERS |        P=0.537N         P=0.218          P=0.500          P=0.691N         P=0.642                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/50 (8%)        5/50 (10%)       3/50 (6%)        3/50 (6%)        1/20 (5%)                        | 
|POLY-3 RATE (b)    |        4/42.94          5/41.68          3/42.63          3/40.90          1/18.68                          | 
|POLY-3 PERCENT (g) |        9.3%             12.0%            7.0%             7.3%             5.4%                             | 
|TERMINAL (d)       |        3/28 (11%)       2/23 (9%)        3/23 (13%)       2/20 (10%)       1/14 (7%)                        | 
|FIRST INCIDENCE    |        387              532              733 (T)          506              733 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.315N         P=0.427          P=0.594N         P=0.630N         P=0.453N                         | 
|POLY 3             |        P=0.379N         P=0.481          P=0.504N         P=0.527N         P=0.494N                         | 
|POLY 1.5           |        P=0.395N         P=0.487          P=0.505N         P=0.515N         P=0.511N                         | 
|POLY 6             |        P=0.352N         P=0.476          P=0.510N         P=0.546N         P=0.467N                         | 
|LOGISTIC REGRESSION|        P=0.415N         P=0.513          P=0.500N         P=0.479N         P=0.577N                         | 
|COCH-ARM / FISHERS |        P=0.412N         P=0.500          P=0.500N         P=0.500N         P=0.556N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        2/42.94          0/40.74          0/42.63          1/40.22          0/18.68                          | 
|POLY-3 PERCENT (g) |        4.7%             0.0%             0.0%             2.5%             0.0%                             | 
|TERMINAL (d)       |        1/28 (4%)        0/23 (0%)        0/23 (0%)        1/20 (5%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        387              ---              ---              733 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.502N         P=0.264N         P=0.264N         P=0.580N         P=0.428N                         | 
|POLY 3             |        P=0.533N         P=0.249N         P=0.238N         P=0.523N         P=0.433N                         | 
|POLY 1.5           |        P=0.539N         P=0.244N         P=0.239N         P=0.513N         P=0.444N                         | 
|POLY 6             |        P=0.522N         P=0.254N         P=0.240N         P=0.538N         P=0.417N                         | 
|LOGISTIC REGRESSION|        P=0.580N         P=0.198N         P=0.186N         P=0.475N         P=0.536N                         | 
|COCH-ARM / FISHERS |        P=0.546N         P=0.247N         P=0.247N         P=0.500N         P=0.507N                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        0/50 (0%)        1/50 (2%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        1/42.29          2/41.61          0/42.63          1/40.22          0/18.68                          | 
|POLY-3 PERCENT (g) |        2.4%             4.8%             0.0%             2.5%             0.0%                             | 
|TERMINAL (d)       |        0/28 (0%)        0/23 (0%)        0/23 (0%)        1/20 (5%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        680              525              ---              733 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.445N         P=0.487          P=0.500N         P=0.706          P=0.627N                         | 
|POLY 3             |        P=0.480N         P=0.494          P=0.498N         P=0.750          P=0.665N                         | 
|POLY 1.5           |        P=0.486N         P=0.497          P=0.500N         P=0.755          P=0.673N                         | 
|POLY 6             |        P=0.469N         P=0.491          P=0.500N         P=0.741          P=0.654N                         | 
|LOGISTIC REGRESSION|        P=0.511N         P=0.524          P=0.500N         P=0.748          P=0.696N                         | 
|COCH-ARM / FISHERS |        P=0.492N         P=0.500          P=0.500N         P=0.753N         P=0.714N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        1/50 (2%)        1/50 (2%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        2/42.29          2/41.61          1/42.63          1/40.22          0/18.68                          | 
|POLY-3 PERCENT (g) |        4.7%             4.8%             2.4%             2.5%             0.0%                             | 
|TERMINAL (d)       |        1/28 (4%)        0/23 (0%)        1/23 (4%)        1/20 (5%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        680              525              733 (T)          733 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.299N         P=0.664          P=0.546N         P=0.595N         P=0.395N                         | 
|POLY 3             |        P=0.328N         P=0.689          P=0.497N         P=0.517N         P=0.429N                         | 
|POLY 1.5           |        P=0.335N         P=0.691          P=0.499N         P=0.509N         P=0.441N                         | 
|POLY 6             |        P=0.315N         P=0.685          P=0.501N         P=0.532N         P=0.413N                         | 
|LOGISTIC REGRESSION|        P=0.343N         P=0.684N         P=0.500N         P=0.537N         P=0.434N                         | 
|COCH-ARM / FISHERS |        P=0.342N         P=0.691N         P=0.500N         P=0.500N         P=0.507N                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        1/50 (2%)        1/50 (2%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        2/42.29          2/41.61          1/42.63          1/40.22          0/18.68                          | 
|POLY-3 PERCENT (g) |        4.7%             4.8%             2.4%             2.5%             0.0%                             | 
|TERMINAL (d)       |        1/28 (4%)        0/23 (0%)        1/23 (4%)        1/20 (5%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        680              525              733 (T)          733 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.299N         P=0.664          P=0.546N         P=0.595N         P=0.395N                         | 
|POLY 3             |        P=0.328N         P=0.689          P=0.497N         P=0.517N         P=0.429N                         | 
|POLY 1.5           |        P=0.335N         P=0.691          P=0.499N         P=0.509N         P=0.441N                         | 
|POLY 6             |        P=0.315N         P=0.685          P=0.501N         P=0.532N         P=0.413N                         | 
|LOGISTIC REGRESSION|        P=0.343N         P=0.684N         P=0.500N         P=0.537N         P=0.434N                         | 
|COCH-ARM / FISHERS |        P=0.342N         P=0.691N         P=0.500N         P=0.500N         P=0.507N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        40/50 (80%)      41/50 (82%)      47/49 (96%)      44/50 (88%)      20/20 (100%)                     | 
|POLY-3 RATE (b)    |        40/45.00         41/46.57         47/48.20         44/48.10         20/20.00                         | 
|POLY-3 PERCENT (g) |        88.9%            88.0%            97.5%            91.5%            100.0%                           | 
|TERMINAL (d)       |        27/28 (96%)      21/23 (91%)      23/23 (100%)     19/20 (95%)      14/14 (100%)                     | 
|FIRST INCIDENCE    |        581              532              596              419              433                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.347N         P=0.175          P=0.037 *        P=0.022 *        P=0.550N                         | 
|POLY 3             |        P=0.089          P=0.591N         P=0.056          P=0.467          P=0.087                          | 
|POLY 1.5           |        P=0.053          P=0.598          P=0.030 *        P=0.325          P=0.052                          | 
|POLY 6             |        P=0.177          P=0.470N         P=0.145          P=0.688          P=0.210                          | 
|LOGISTIC REGRESSION|        P=0.029 *        P=0.341          P=0.060          P=0.111          P=0.049 *                        | 
|COCH-ARM / FISHERS |        P=0.031 *        P=0.500          P=0.015 *        P=0.207          P=0.026 *                        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/50 (14%)       4/50 (8%)        4/49 (8%)        3/49 (6%)        2/20 (10%)                       | 
|POLY-3 RATE (b)    |        7/42.70          4/40.97          4/43.27          3/39.85          2/18.78                          | 
|POLY-3 PERCENT (g) |        16.4%            9.8%             9.2%             7.5%             10.7%                            | 
|TERMINAL (d)       |        5/28 (18%)       1/23 (4%)        2/23 (9%)        1/20 (5%)        1/14 (7%)                        | 
|FIRST INCIDENCE    |        581              694              602              617              708                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.381N         P=0.352N         P=0.330N         P=0.270N         P=0.344N                         | 
|POLY 3             |        P=0.487N         P=0.283N         P=0.251N         P=0.184N         P=0.422N                         | 
|POLY 1.5           |        P=0.505N         P=0.274N         P=0.258N         P=0.176N         P=0.447N                         | 
|POLY 6             |        P=0.455N         P=0.295N         P=0.251N         P=0.199N         P=0.384N                         | 
|LOGISTIC REGRESSION|        P=0.471N         P=0.288N         P=0.259N         P=0.186N         P=0.415N                         | 
|COCH-ARM / FISHERS |        P=0.523N         P=0.262N         P=0.274N         P=0.167N         P=0.495N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        1/49 (2%)        0/49 (0%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/42.09          2/40.74          1/42.63          0/39.27          0/18.68                          | 
|POLY-3 PERCENT (g) |        0.0%             4.9%             2.4%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/28 (0%)        2/23 (9%)        1/23 (4%)        0/20 (0%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        ---              733 (T)          733 (T)          ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.483N         P=0.195          P=0.461          (e)              (e)                              | 
|POLY 3             |        P=0.543N         P=0.230          P=0.503          (e)              (e)                              | 
|POLY 1.5           |        P=0.545N         P=0.233          P=0.501          (e)              (e)                              | 
|POLY 6             |        P=0.537N         P=0.225          P=0.501          (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              P=0.195          P=0.461          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.546N         P=0.247          P=0.495          (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/50 (14%)       6/50 (12%)       5/49 (10%)       3/49 (6%)        2/20 (10%)                       | 
|POLY-3 RATE (b)    |        7/42.70          6/40.97          5/43.27          3/39.85          2/18.78                          | 
|POLY-3 PERCENT (g) |        16.4%            14.7%            11.6%            7.5%             10.7%                            | 
|TERMINAL (d)       |        5/28 (18%)       3/23 (13%)       3/23 (13%)       1/20 (5%)        1/14 (7%)                        | 
|FIRST INCIDENCE    |        581              694              602              617              708                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.287N         P=0.612N         P=0.464N         P=0.270N         P=0.344N                         | 
|POLY 3             |        P=0.381N         P=0.532N         P=0.368N         P=0.184N         P=0.422N                         | 
|POLY 1.5           |        P=0.400N         P=0.518N         P=0.375N         P=0.176N         P=0.447N                         | 
|POLY 6             |        P=0.348N         P=0.551N         P=0.370N         P=0.199N         P=0.384N                         | 
|LOGISTIC REGRESSION|        P=0.353N         P=0.543N         P=0.374N         P=0.186N         P=0.415N                         | 
|COCH-ARM / FISHERS |        P=0.419N         P=0.500N         P=0.394N         P=0.167N         P=0.495N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)        2/50 (4%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/42.09          0/40.74          2/42.76          2/40.40          0/18.68                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             4.7%             5.0%             0.0%                             | 
|TERMINAL (d)       |        0/28 (0%)        0/23 (0%)        1/23 (4%)        1/20 (5%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              699              688              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.655N         (e)              P=0.215          P=0.184          (e)                              | 
|POLY 3             |        P=0.716N         (e)              P=0.240          P=0.228          (e)                              | 
|POLY 1.5           |        P=0.732N         (e)              P=0.238          P=0.232          (e)                              | 
|POLY 6             |        P=0.692N         (e)              P=0.240          P=0.220          (e)                              | 
|LOGISTIC REGRESSION|        P=0.703N         (e)              P=0.236          P=0.218          (e)                              | 
|COCH-ARM / FISHERS |        P=0.751N         (e)              P=0.247          P=0.247          (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)        0/50 (0%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/42.09          2/41.72          0/42.63          0/40.22          0/18.68                          | 
|POLY-3 PERCENT (g) |        0.0%             4.8%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/28 (0%)        0/23 (0%)        0/23 (0%)        0/20 (0%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        ---              509              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.603N         P=0.239          (e)              (e)              (e)                              | 
|POLY 3             |        P=0.628N         P=0.235          (e)              (e)              (e)                              | 
|POLY 1.5           |        P=0.626N         P=0.236          (e)              (e)              (e)                              | 
|POLY 6             |        P=0.627N         P=0.233          (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.672N         P=0.261          (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.623N         P=0.247          (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        19/50 (38%)      23/50 (46%)      27/50 (54%)      25/50 (50%)      10/20 (50%)                      | 
|POLY-3 RATE (b)    |        19/44.35         23/45.99         27/47.39         25/44.76         10/19.93                         | 
|POLY-3 PERCENT (g) |        42.8%            50.0%            57.0%            55.9%            50.2%                            | 
|TERMINAL (d)       |        8/28 (29%)       8/23 (35%)       8/23 (35%)       9/20 (45%)       5/14 (36%)                       | 
|FIRST INCIDENCE    |        614              315              596              529              433                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.414N         P=0.192          P=0.092          P=0.062          P=0.566                          | 
|POLY 3             |        P=0.482          P=0.316          P=0.122          P=0.149          P=0.389                          | 
|POLY 1.5           |        P=0.418          P=0.300          P=0.097          P=0.152          P=0.333                          | 
|POLY 6             |        P=0.563          P=0.329          P=0.153          P=0.141          P=0.458                          | 
|LOGISTIC REGRESSION|        P=0.328          P=0.273          P=0.080          P=0.134          P=0.285                          | 
|COCH-ARM / FISHERS |        P=0.328          P=0.272          P=0.080          P=0.157          P=0.256                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        2/50 (4%)        5/50 (10%)       0/20 (0%)                        | 
|POLY-3 RATE (b)    |        1/42.09          2/41.01          2/42.63          5/41.28          0/18.68                          | 
|POLY-3 PERCENT (g) |        2.4%             4.9%             4.7%             12.1%            0.0%                             | 
|TERMINAL (d)       |        1/28 (4%)        0/23 (0%)        2/23 (9%)        2/20 (10%)       0/14 (0%)                        | 
|FIRST INCIDENCE    |        733 (T)          688              733 (T)          419              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.439N         P=0.470          P=0.431          P=0.064          P=0.638N                         | 
|POLY 3             |        P=0.485N         P=0.491          P=0.504          P=0.095          P=0.665N                         | 
|POLY 1.5           |        P=0.512N         P=0.495          P=0.502          P=0.099          P=0.672N                         | 
|POLY 6             |        P=0.445N         P=0.487          P=0.503          P=0.089          P=0.653N                         | 
|LOGISTIC REGRESSION|        P=0.536N         P=0.484          P=0.431          P=0.106          (e)                              | 
|COCH-ARM / FISHERS |        P=0.546N         P=0.500          P=0.500          P=0.102          P=0.714N                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        2/50 (4%)        5/50 (10%)       0/20 (0%)                        | 
|POLY-3 RATE (b)    |        1/42.09          2/41.01          2/42.63          5/41.28          0/18.68                          | 
|POLY-3 PERCENT (g) |        2.4%             4.9%             4.7%             12.1%            0.0%                             | 
|TERMINAL (d)       |        1/28 (4%)        0/23 (0%)        2/23 (9%)        2/20 (10%)       0/14 (0%)                        | 
|FIRST INCIDENCE    |        733 (T)          688              733 (T)          419              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.439N         P=0.470          P=0.431          P=0.064          P=0.638N                         | 
|POLY 3             |        P=0.485N         P=0.491          P=0.504          P=0.095          P=0.665N                         | 
|POLY 1.5           |        P=0.512N         P=0.495          P=0.502          P=0.099          P=0.672N                         | 
|POLY 6             |        P=0.445N         P=0.487          P=0.503          P=0.089          P=0.653N                         | 
|LOGISTIC REGRESSION|        P=0.536N         P=0.484          P=0.431          P=0.106          (e)                              | 
|COCH-ARM / FISHERS |        P=0.546N         P=0.500          P=0.500          P=0.102          P=0.714N                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/42.09          0/40.74          0/42.63          2/40.40          0/18.68                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.0%             0.0%                             | 
|TERMINAL (d)       |        0/28 (0%)        0/23 (0%)        0/23 (0%)        1/20 (5%)        0/14 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              688              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.758          (e)              (e)              P=0.184          (e)                              | 
|POLY 3             |        P=0.795          (e)              (e)              P=0.228          (e)                              | 
|POLY 1.5           |        P=0.776          (e)              (e)              P=0.232          (e)                              | 
|POLY 6             |        P=0.819          (e)              (e)              P=0.220          (e)                              | 
|LOGISTIC REGRESSION|        P=0.756          (e)              (e)              P=0.218          (e)                              | 
|COCH-ARM / FISHERS |        P=0.749          (e)              (e)              P=0.247          (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        47/50 (94%)      49/50 (98%)      49/50 (98%)      48/50 (96%)      20/20 (100%)                     | 
|POLY-3 RATE (b)    |        47/47.82         49/49.08         49/49.00         48/49.09         20/20.00                         | 
|POLY-3 PERCENT (g) |        98.3%            99.8%            100.0%           97.8%            100.0%                           | 
|TERMINAL (d)       |        28/28 (100%)     23/23 (100%)     23/23 (100%)     20/20 (100%)     14/14 (100%)                     | 
|FIRST INCIDENCE    |        561              509              574              419              433                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.114N         P=0.140          P=0.192          P=0.067          P=0.212N                         | 
|POLY 3             |        P=0.816          P=0.670          P=0.620          P=0.751N         P=0.849                          | 
|POLY 1.5           |        P=0.631          P=0.397          P=0.283          P=0.720          P=0.555                          | 
|POLY 6             |        P=0.926          P=0.998          P=0.998          P=0.657N         P=1.000                          | 
|LOGISTIC REGRESSION|        P=0.379          P=0.220          P=0.761          P=0.420          P=0.311                          | 
|COCH-ARM / FISHERS |        P=0.351          P=0.309          P=0.309          P=0.500          P=0.358                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DECALIN               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/50 (54%)      29/50 (58%)      32/50 (64%)      42/50 (84%)      13/20 (65%)                      | 
|POLY-3 RATE (b)    |        27/46.01         29/47.85         32/47.61         42/48.40         13/20.00                         | 
|POLY-3 PERCENT (g) |        58.7%            60.6%            67.2%            86.8%            65.0%                            | 
|TERMINAL (d)       |        14/28 (50%)      9/23 (39%)       11/23 (48%)      16/20 (80%)      7/14 (50%)                       | 
|FIRST INCIDENCE    |        387              315              596              379              433                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.425N         P=0.275          P=0.173          P<0.001 **       P=0.503N                         | 
|POLY 3             |        P=0.309          P=0.508          P=0.256          P<0.001 **       P=0.415                          | 
|POLY 1.5           |        P=0.250          P=0.468          P=0.218          P<0.001 **       P=0.354                          | 
|POLY 6             |        P=0.398          P=0.566          P=0.313          P<0.001 **       P=0.503                          | 
|LOGISTIC REGRESSION|        P=0.163          P=0.447          P=0.207          P<0.001 **       P=0.273                          | 
|COCH-ARM / FISHERS |        P=0.185          P=0.420          P=0.208          P<0.001 **       P=0.285                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          25 PPM           50 PPM           100 PPM          400 PPM                          | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        49/50 (98%)      50/50 (100%)     49/50 (98%)      50/50 (100%)     20/20 (100%)                     | 
|POLY-3 RATE (b)    |        49/49.49         50/50.00         49/49.00         50/50.00         20/20.00                         | 
|POLY-3 PERCENT (g) |        99.0%            100.0%           100.0%           100.0%           100.0%                           | 
|TERMINAL (d)       |        28/28 (100%)     23/23 (100%)     23/23 (100%)     20/20 (100%)     14/14 (100%)                     | 
|FIRST INCIDENCE    |        387              315              574              379              433                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.094N         P=0.184          P=0.288          P=0.072          P=0.156N                         | 
|POLY 3             |        P=0.984          P=0.851          P=0.853          P=0.851          P=0.947                          | 
|POLY 1.5           |        P=0.899          P=0.665          P=0.672          P=0.665          P=0.827                          | 
|POLY 6             |        P=1.000          P=0.999          P=0.999          P=0.999          P=1.000                          | 
|LOGISTIC REGRESSION|        P=0.790          P=0.473          P=0.685          P=0.480          P=0.746                          | 
|COCH-ARM / FISHERS |        P=0.623          P=0.500          P=0.753N         P=0.500          P=0.714                          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
                                                                                                                                   
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).