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TDMS Study 93026-07 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 08/28/01       
EXPERIMENT: 93026 TEST: 07                                                                                     TIME: 09:21:58       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 91-17-8         
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                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 002    CONTROL                                                                       
                                       INCLUDE 004    25 PPM                                                                        
                                       INCLUDE 007    100 PPM                                                                       
                                       INCLUDE 009    400 PPM                                                                       
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 08/28/01       
EXPERIMENT: 93026 TEST: 07                                                                                     TIME: 09:21:58       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 91-17-8         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     DECALIN                                                                                      
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Brain                                  Hemorrhage                                                                                   
Eye                                    Atrophy                                                                                      
Eye: Lens                              Cataract                                                                                     
Kidney                                 Nephropathy Chronic                                                                          
Kidney: Pelvis                         Mineralization                                                                               
Larynx                                 Foreign Body                                                                                 
                                       Inflammation                                                                                 
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
                                       Proteinosis                                                                                  
Lung: Interstitium                     Fibrosis                                                                                     
Pleura                                 Inflammation Chronic                                                                         
Spleen                                 Fibrosis                                                                                     
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                      DECALIN     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                0/48 (0%)                2/49 (4%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  3/44.73                  0/45.50                  2/46.14                  2/40.74         | 
|POLY-3 PERCENT (g) |                  6.7%                     0.0%                     4.3%                     4.9%            | 
|TERMINAL (d)       |                  2/32 (6%)                0/35 (0%)                2/39 (5%)                2/28 (7%)       | 
|FIRST INCIDENCE    |                  680                      ---                      734 (T)                  734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.486                  P=0.107N                 P=0.420N                 P=0.558N        | 
|POLY 3             |                  P=0.510                  P=0.116N                 P=0.486N                 P=0.543N        | 
|POLY 1.5           |                  P=0.533                  P=0.120N                 P=0.496N                 P=0.527N        | 
|POLY 6             |                  P=0.480                  P=0.110N                 P=0.472N                 P=0.563N        | 
|LOGISTIC REGRESSION|                  P=0.486                  P=0.118N                 P=0.472N                 P=0.566N        | 
|COCH-ARM / FISHERS |                  P=0.565                  P=0.129N                 P=0.510N                 P=0.510N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/50 (14%)               7/48 (15%)               11/49 (22%)              8/49 (16%)      | 
|POLY-3 RATE (b)    |                  7/44.73                  7/45.91                  11/46.14                 8/41.55         | 
|POLY-3 PERCENT (g) |                  15.7%                    15.3%                    23.8%                    19.3%           | 
|TERMINAL (d)       |                  6/32 (19%)               4/35 (11%)               11/39 (28%)              5/28 (18%)      | 
|FIRST INCIDENCE    |                  680                      638                      734 (T)                  634             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.309                  P=0.536N                 P=0.367                  P=0.389         | 
|POLY 3             |                  P=0.405                  P=0.593N                 P=0.237                  P=0.438         | 
|POLY 1.5           |                  P=0.446                  P=0.613                  P=0.222                  P=0.458         | 
|POLY 6             |                  P=0.357                  P=0.566N                 P=0.258                  P=0.415         | 
|LOGISTIC REGRESSION|                  P=0.348                  P=0.585N                 P=0.309                  P=0.403         | 
|COCH-ARM / FISHERS |                  P=0.501                  P=0.581                  P=0.204                  P=0.483         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                2/48 (4%)                0/49 (0%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  3/44.85                  2/45.50                  0/46.14                  0/40.74         | 
|POLY-3 PERCENT (g) |                  6.7%                     4.4%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                2/35 (6%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  666                      734 (T)                  ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.121N                 P=0.464N                 P=0.103N                 P=0.160N        | 
|POLY 3             |                  P=0.109N                 P=0.493N                 P=0.114N                 P=0.136N        | 
|POLY 1.5           |                  P=0.104N                 P=0.503N                 P=0.117N                 P=0.130N        | 
|POLY 6             |                  P=0.115N                 P=0.482N                 P=0.109N                 P=0.146N        | 
|LOGISTIC REGRESSION|                  P=0.105N                 P=0.498N                 P=0.124N                 P=0.132N        | 
|COCH-ARM / FISHERS |                  P=0.098N                 P=0.520N                 P=0.125N                 P=0.125N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               5/49 (10%)               6/49 (12%)               3/50 (6%)       | 
|POLY-3 RATE (b)    |                  6/46.18                  5/45.84                  6/46.58                  3/42.76         | 
|POLY-3 PERCENT (g) |                  13.0%                    10.9%                    12.9%                    7.0%            | 
|TERMINAL (d)       |                  2/32 (6%)                4/35 (11%)               4/39 (10%)               0/28 (0%)       | 
|FIRST INCIDENCE    |                  525                      728                      665                      538             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.309N                 P=0.448N                 P=0.527N                 P=0.311N        | 
|POLY 3             |                  P=0.254N                 P=0.505N                 P=0.615N                 P=0.281N        | 
|POLY 1.5           |                  P=0.232N                 P=0.508N                 P=0.617                  P=0.264N        | 
|POLY 6             |                  P=0.283N                 P=0.500N                 P=0.600N                 P=0.304N        | 
|LOGISTIC REGRESSION|                  P=0.156N                 P=0.570N                 P=0.554                  P=0.175N        | 
|COCH-ARM / FISHERS |                  P=0.203N                 P=0.514N                 P=0.606                  P=0.243N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                1/49 (2%)                3/49 (6%)                6/50 (12%)      | 
|POLY-3 RATE (b)    |                  1/44.52                  1/46.08                  3/47.21                  6/43.72         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.2%                     6.4%                     13.7%           | 
|TERMINAL (d)       |                  1/32 (3%)                0/35 (0%)                1/39 (3%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  663                      349                      492             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.008 **               P=0.745N                 P=0.351                  P=0.048 *       | 
|POLY 3             |                  P=0.011 *                P=0.753N                 P=0.327                  P=0.052         | 
|POLY 1.5           |                  P=0.013 *                P=0.758N                 P=0.315                  P=0.054         | 
|POLY 6             |                  P=0.010 *                P=0.746N                 P=0.341                  P=0.051         | 
|LOGISTIC REGRESSION|                  P=0.040 *                P=0.753                  P=0.237                  P=0.073         | 
|COCH-ARM / FISHERS |                  P=0.015 *                P=0.747                  P=0.301                  P=0.056         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/48 (4%)                3/49 (6%)                2/49 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/43.41                  3/45.92                  2/46.14                  1/41.60         | 
|POLY-3 PERCENT (g) |                  4.6%                     6.5%                     4.3%                     2.4%            | 
|TERMINAL (d)       |                  2/31 (7%)                2/35 (6%)                2/39 (5%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  734 (T)                  708                      734 (T)                  734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.376N                 P=0.558                  P=0.610N                 P=0.536N        | 
|POLY 3             |                  P=0.334N                 P=0.526                  P=0.672N                 P=0.515N        | 
|POLY 1.5           |                  P=0.317N                 P=0.518                  P=0.679N                 P=0.503N        | 
|POLY 6             |                  P=0.354N                 P=0.539                  P=0.660N                 P=0.529N        | 
|LOGISTIC REGRESSION|                  P=0.379N                 P=0.555                  P=0.610N                 P=0.536N        | 
|COCH-ARM / FISHERS |                  P=0.293N                 P=0.510                  P=0.684N                 P=0.485N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/48 (6%)                3/49 (6%)                1/49 (2%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  3/43.66                  3/45.84                  1/46.14                  3/41.60         | 
|POLY-3 PERCENT (g) |                  6.9%                     6.6%                     2.2%                     7.2%            | 
|TERMINAL (d)       |                  2/31 (7%)                2/35 (6%)                1/39 (3%)                3/28 (11%)      | 
|FIRST INCIDENCE    |                  666                      728                      734 (T)                  734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.476                  P=0.610N                 P=0.242N                 P=0.609         | 
|POLY 3             |                  P=0.537                  P=0.640N                 P=0.286N                 P=0.640         | 
|POLY 1.5           |                  P=0.557                  P=0.646N                 P=0.292N                 P=0.657         | 
|POLY 6             |                  P=0.511                  P=0.629N                 P=0.276N                 P=0.619         | 
|LOGISTIC REGRESSION|                  P=0.487                  P=0.632N                 P=0.288N                 P=0.617         | 
|COCH-ARM / FISHERS |                  P=0.586                  P=0.651N                 P=0.301N                 P=0.641N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/1 (0%)                 2/2 (100%)               0/5 (0%)                 0/4 (0%)        | 
|POLY-3 RATE (b)    |                  0/1.00                   2/2.00                   0/4.75                   0/3.46          | 
|POLY-3 PERCENT (g) |                  0.0%                     100.0%                   0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/1 (0%)                 0/0 (0%)                 0/4 (0%)                 0/3 (0%)        | 
|FIRST INCIDENCE    |                  ---                      638                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.434N                 P=0.253                  (e)                      (e)             | 
|POLY 3             |                  P<0.001N**               P=1.000N                 (e)                      (e)             | 
|POLY 1.5           |                  P<0.001N**               P=1.000N                 (e)                      (e)             | 
|POLY 6             |                  P<0.001N**               P=1.000N                 (e)                      (e)             | 
|LOGISTIC REGRESSION|                  P=0.129N                 (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.221N                 P=0.333                  (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Lens                                                                                                                        | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/1 (100%)               0/2 (0%)                 3/5 (60%)                2/4 (50%)       | 
|POLY-3 RATE (b)    |                  1/1.00                   0/1.39                   3/5.00                   2/3.46          | 
|POLY-3 PERCENT (g) |                  100.0%                   0.0%                     60.0%                    57.8%           | 
|TERMINAL (d)       |                  1/1 (100%)               0/0 (0%)                 2/4 (50%)                2/3 (67%)       | 
|FIRST INCIDENCE    |                  734 (T)                  ---                      666                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.683N                 P=1.000N                 P=0.743                  P=0.718N        | 
|POLY 3             |                  P=0.710                  P<0.001N**               P=0.631N                 P=0.652N        | 
|POLY 1.5           |                  P=0.690                  P<0.001N**               P=0.631N                 P=0.618N        | 
|POLY 6             |                  P=0.700N                 P=0.574N                 P=0.631N                 P=0.691N        | 
|LOGISTIC REGRESSION|                  P=0.732                  (e)                      (e)                      P=0.718N        | 
|COCH-ARM / FISHERS |                  P=0.674                  P=0.333N                 P=0.667N                 P=0.600N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)                1/49 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.52                  2/46.62                  1/46.35                  0/41.60         | 
|POLY-3 PERCENT (g) |                  4.5%                     4.3%                     2.2%                     0.0%            | 
|TERMINAL (d)       |                  2/32 (6%)                0/35 (0%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  722                      680                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.192N                 P=0.642N                 P=0.443N                 P=0.268N        | 
|POLY 3             |                  P=0.175N                 P=0.677N                 P=0.486N                 P=0.252N        | 
|POLY 1.5           |                  P=0.167N                 P=0.684N                 P=0.495N                 P=0.245N        | 
|POLY 6             |                  P=0.185N                 P=0.668N                 P=0.473N                 P=0.262N        | 
|LOGISTIC REGRESSION|                  P=0.171N                 P=0.661N                 P=0.494N                 (e)             | 
|COCH-ARM / FISHERS |                  P=0.156N                 P=0.691N                 P=0.508N                 P=0.247N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/46 (4%)                1/49 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/44.52                  2/43.79                  1/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  2.3%                     4.6%                     2.2%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                2/35 (6%)                1/39 (3%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  734 (T)                  734 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.275N                 P=0.531                  P=0.717N                 P=0.527N        | 
|POLY 3             |                  P=0.251N                 P=0.494                  P=0.753N                 P=0.514N        | 
|POLY 1.5           |                  P=0.242N                 P=0.485                  P=0.758N                 P=0.507N        | 
|POLY 6             |                  P=0.262N                 P=0.507                  P=0.745N                 P=0.522N        | 
|LOGISTIC REGRESSION|                  P=0.275N                 P=0.531                  P=0.717N                 (e)             | 
|COCH-ARM / FISHERS |                  P=0.231N                 P=0.468                  P=0.747                  P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy Chronic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  43/50 (86%)              45/46 (98%)              48/49 (98%)              48/50 (96%)     | 
|POLY-3 RATE (b)    |                  43/47.48                 45/46.00                 48/48.11                 48/49.14        | 
|POLY-3 PERCENT (g) |                  90.6%                    97.8%                    99.8%                    97.7%           | 
|TERMINAL (d)       |                  31/32 (97%)              34/35 (97%)              39/39 (100%)             28/28 (100%)    | 
|FIRST INCIDENCE    |                  561                      533                      617                      492             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.004 **               P=0.421N                 P=0.343N                 P=0.042 *       | 
|POLY 3             |                  P=0.245                  P=0.122                  P=0.029 *                P=0.114         | 
|POLY 1.5           |                  P=0.231                  P=0.076                  P=0.024 *                P=0.094         | 
|POLY 6             |                  P=0.273                  P=0.218                  P=0.052                  P=0.156         | 
|LOGISTIC REGRESSION|                  P=0.057                  P=0.110                  P=0.068                  P=0.027 *       | 
|COCH-ARM / FISHERS |                  P=0.223                  P=0.039 *                P=0.032 *                P=0.080         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex, Renal Tubule                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                4/46 (9%)                4/49 (8%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/44.52                  4/43.79                  4/46.19                  2/41.60         | 
|POLY-3 PERCENT (g) |                  2.3%                     9.1%                     8.7%                     4.8%            | 
|TERMINAL (d)       |                  1/32 (3%)                4/35 (11%)               3/39 (8%)                2/28 (7%)       | 
|FIRST INCIDENCE    |                  734 (T)                  734 (T)                  722                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.617N                 P=0.206                  P=0.245                  P=0.453         | 
|POLY 3             |                  P=0.537N                 P=0.173                  P=0.190                  P=0.476         | 
|POLY 1.5           |                  P=0.514N                 P=0.166                  P=0.182                  P=0.487         | 
|POLY 6             |                  P=0.567N                 P=0.184                  P=0.201                  P=0.462         | 
|LOGISTIC REGRESSION|                  P=0.621                  P=0.206                  P=0.220                  P=0.453         | 
|COCH-ARM / FISHERS |                  P=0.485N                 P=0.156                  P=0.175                  P=0.500         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                2/46 (4%)                4/49 (8%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  3/44.95                  2/43.79                  4/46.14                  4/41.92         | 
|POLY-3 PERCENT (g) |                  6.7%                     4.6%                     8.7%                     9.5%            | 
|TERMINAL (d)       |                  1/32 (3%)                2/35 (6%)                4/39 (10%)               3/28 (11%)      | 
|FIRST INCIDENCE    |                  666                      734 (T)                  734 (T)                  644             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.254                  P=0.463N                 P=0.588                  P=0.426         | 
|POLY 3             |                  P=0.324                  P=0.512N                 P=0.514                  P=0.462         | 
|POLY 1.5           |                  P=0.351                  P=0.522N                 P=0.503                  P=0.479         | 
|POLY 6             |                  P=0.291                  P=0.499N                 P=0.528                  P=0.439         | 
|LOGISTIC REGRESSION|                  P=0.315                  P=0.534N                 P=0.514                  P=0.472         | 
|COCH-ARM / FISHERS |                  P=0.385                  P=0.540N                 P=0.489                  P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  11/50 (22%)              16/46 (35%)              19/49 (39%)              18/50 (36%)     | 
|POLY-3 RATE (b)    |                  11/46.35                 16/43.97                 19/46.19                 18/43.66        | 
|POLY-3 PERCENT (g) |                  23.7%                    36.4%                    41.1%                    41.2%           | 
|TERMINAL (d)       |                  5/32 (16%)               13/35 (37%)              18/39 (46%)              14/28 (50%)     | 
|FIRST INCIDENCE    |                  525                      706                      722                      478             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.048 *                P=0.279                  P=0.176                  P=0.053         | 
|POLY 3             |                  P=0.135                  P=0.138                  P=0.056                  P=0.057         | 
|POLY 1.5           |                  P=0.173                  P=0.132                  P=0.055                  P=0.072         | 
|POLY 6             |                  P=0.092                  P=0.145                  P=0.057                  P=0.039 *       | 
|LOGISTIC REGRESSION|                  P=0.138                  P=0.130                  P=0.066                  P=0.091         | 
|COCH-ARM / FISHERS |                  P=0.224                  P=0.122                  P=0.055                  P=0.093         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis, Transitional Epithelium                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/46 (4%)                2/49 (4%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  2/43.86                  2/46.14                  2/41.60         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.6%                     4.3%                     4.8%            | 
|TERMINAL (d)       |                  0/32 (0%)                0/35 (0%)                2/39 (5%)                2/28 (7%)       | 
|FIRST INCIDENCE    |                  ---                      722                      734 (T)                  734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.300                  P=0.274                  P=0.283                  P=0.209         | 
|POLY 3             |                  P=0.361                  P=0.234                  P=0.245                  P=0.222         | 
|POLY 1.5           |                  P=0.378                  P=0.228                  P=0.240                  P=0.229         | 
|POLY 6             |                  P=0.339                  P=0.242                  P=0.253                  P=0.213         | 
|LOGISTIC REGRESSION|                  P=0.302                  P=0.241                  P=0.283                  P=0.209         | 
|COCH-ARM / FISHERS |                  P=0.400                  P=0.227                  P=0.242                  P=0.247         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                1/49 (2%)                0/49 (0%)                3/48 (6%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  1/45.86                  0/46.14                  3/41.05         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.2%                     0.0%                     7.3%            | 
|TERMINAL (d)       |                  0/32 (0%)                0/35 (0%)                0/39 (0%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  ---                      722                      ---                      580             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.027 *                P=0.538                  (e)                      P=0.110         | 
|POLY 3             |                  P=0.033 *                P=0.506                  (e)                      P=0.104         | 
|POLY 1.5           |                  P=0.035 *                P=0.502                  (e)                      P=0.108         | 
|POLY 6             |                  P=0.031 *                P=0.512                  (e)                      P=0.101         | 
|LOGISTIC REGRESSION|                  P=0.057                  P=0.509                  (e)                      P=0.128         | 
|COCH-ARM / FISHERS |                  P=0.038 *                P=0.495                  (e)                      P=0.114         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/49 (4%)                0/49 (0%)                4/48 (8%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  2/45.86                  0/46.14                  4/41.05         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.4%                     0.0%                     9.7%            | 
|TERMINAL (d)       |                  0/32 (0%)                1/35 (3%)                0/39 (0%)                2/28 (7%)       | 
|FIRST INCIDENCE    |                  ---                      722                      ---                      580             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.018 *                P=0.271                  (e)                      P=0.054         | 
|POLY 3             |                  P=0.024 *                P=0.244                  (e)                      P=0.050         | 
|POLY 1.5           |                  P=0.026 *                P=0.239                  (e)                      P=0.052         | 
|POLY 6             |                  P=0.023 *                P=0.250                  (e)                      P=0.048 *       | 
|LOGISTIC REGRESSION|                  P=0.039 *                P=0.256                  (e)                      P=0.066         | 
|COCH-ARM / FISHERS |                  P=0.029 *                P=0.242                  (e)                      P=0.054         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                4/49 (8%)                2/49 (4%)                2/48 (4%)       | 
|POLY-3 RATE (b)    |                  2/44.70                  4/45.81                  2/46.14                  2/40.17         | 
|POLY-3 PERCENT (g) |                  4.5%                     8.7%                     4.3%                     5.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                4/35 (11%)               2/39 (5%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  688                      734 (T)                  734 (T)                  706             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.550N                 P=0.382                  P=0.630N                 P=0.647         | 
|POLY 3             |                  P=0.506N                 P=0.349                  P=0.682N                 P=0.655         | 
|POLY 1.5           |                  P=0.488N                 P=0.340                  P=0.690N                 P=0.666         | 
|POLY 6             |                  P=0.526N                 P=0.360                  P=0.672N                 P=0.642         | 
|LOGISTIC REGRESSION|                  P=0.553N                 P=0.370                  P=0.676N                 P=0.650         | 
|COCH-ARM / FISHERS |                  P=0.466N                 P=0.329                  P=0.684                  P=0.676         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/48 (4%)                0/49 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  1/44.52                  2/45.08                  0/46.14                  1/41.60         | 
|POLY-3 PERCENT (g) |                  2.3%                     4.4%                     0.0%                     2.4%            | 
|TERMINAL (d)       |                  1/32 (3%)                2/35 (6%)                0/39 (0%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  734 (T)                  734 (T)                  ---                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.662N                 P=0.531                  P=0.461N                 P=0.732         | 
|POLY 3             |                  P=0.605N                 P=0.504                  P=0.493N                 P=0.746         | 
|POLY 1.5           |                  P=0.598N                 P=0.497                  P=0.498N                 P=0.752         | 
|POLY 6             |                  P=0.614N                 P=0.515                  P=0.486N                 P=0.736         | 
|LOGISTIC REGRESSION|                  P=0.662N                 P=0.531                  (e)                      P=0.732         | 
|COCH-ARM / FISHERS |                  P=0.587N                 P=0.485                  P=0.505N                 P=0.753N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/48 (4%)                1/49 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  2/45.08                  1/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.4%                     2.2%                     0.0%            | 
|TERMINAL (d)       |                  0/32 (0%)                2/35 (6%)                1/39 (3%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  ---                      734 (T)                  734 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.411N                 P=0.258                  P=0.539                  (e)             | 
|POLY 3             |                  P=0.379N                 P=0.240                  P=0.507                  (e)             | 
|POLY 1.5           |                  P=0.371N                 P=0.235                  P=0.502                  (e)             | 
|POLY 6             |                  P=0.390N                 P=0.247                  P=0.514                  (e)             | 
|LOGISTIC REGRESSION|                  (e)                      P=0.258                  P=0.539                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.362N                 P=0.237                  P=0.495                  (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/50 (14%)               5/48 (10%)               4/49 (8%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  7/44.52                  5/45.49                  4/46.14                  2/42.27         | 
|POLY-3 PERCENT (g) |                  15.7%                    11.0%                    8.7%                     4.7%            | 
|TERMINAL (d)       |                  7/32 (22%)               4/35 (11%)               4/39 (10%)               0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  613                      734 (T)                  566             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.132N                 P=0.317N                 P=0.156N                 P=0.115N        | 
|POLY 3             |                  P=0.104N                 P=0.364N                 P=0.240N                 P=0.091N        | 
|POLY 1.5           |                  P=0.093N                 P=0.382N                 P=0.255N                 P=0.085N        | 
|POLY 6             |                  P=0.119N                 P=0.337N                 P=0.221N                 P=0.097N        | 
|LOGISTIC REGRESSION|                  P=0.099N                 P=0.348N                 P=0.156N                 P=0.099N        | 
|COCH-ARM / FISHERS |                  P=0.080N                 P=0.409N                 P=0.274N                 P=0.080N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  9/50 (18%)               6/48 (13%)               6/49 (12%)               7/50 (14%)      | 
|POLY-3 RATE (b)    |                  9/45.08                  6/45.21                  6/46.40                  7/42.53         | 
|POLY-3 PERCENT (g) |                  20.0%                    13.3%                    12.9%                    16.5%           | 
|TERMINAL (d)       |                  7/32 (22%)               4/35 (11%)               5/39 (13%)               5/28 (18%)      | 
|FIRST INCIDENCE    |                  652                      706                      665                      538             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.469                  P=0.233N                 P=0.180N                 P=0.510N        | 
|POLY 3             |                  P=0.570N                 P=0.284N                 P=0.266N                 P=0.441N        | 
|POLY 1.5           |                  P=0.537N                 P=0.298N                 P=0.282N                 P=0.419N        | 
|POLY 6             |                  P=0.536                  P=0.266N                 P=0.246N                 P=0.473N        | 
|LOGISTIC REGRESSION|                  P=0.572N                 P=0.266N                 P=0.261N                 P=0.441N        | 
|COCH-ARM / FISHERS |                  P=0.495N                 P=0.318N                 P=0.303N                 P=0.393N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                2/48 (4%)                0/49 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.52                  2/45.12                  0/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  4.5%                     4.4%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/32 (6%)                1/35 (3%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  722                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.178N                 P=0.652N                 P=0.196N                 P=0.268N        | 
|POLY 3             |                  P=0.161N                 P=0.689N                 P=0.229N                 P=0.252N        | 
|POLY 1.5           |                  P=0.156N                 P=0.690                  P=0.235N                 P=0.245N        | 
|POLY 6             |                  P=0.168N                 P=0.677N                 P=0.222N                 P=0.262N        | 
|LOGISTIC REGRESSION|                  P=0.178N                 P=0.656N                 (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.149N                 P=0.676                  P=0.253N                 P=0.247N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                0/48 (0%)                2/49 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/45.23                  0/45.08                  2/47.04                  0/41.60         | 
|POLY-3 PERCENT (g) |                  6.6%                     0.0%                     4.3%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                0/35 (0%)                1/39 (3%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  525                      ---                      349                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.220N                 P=0.110N                 P=0.454N                 P=0.145N        | 
|POLY 3             |                  P=0.218N                 P=0.119N                 P=0.482N                 P=0.134N        | 
|POLY 1.5           |                  P=0.205N                 P=0.122N                 P=0.493N                 P=0.127N        | 
|POLY 6             |                  P=0.237N                 P=0.115N                 P=0.469N                 P=0.144N        | 
|LOGISTIC REGRESSION|                  P=0.137N                 P=0.157N                 P=0.600N                 P=0.106N        | 
|COCH-ARM / FISHERS |                  P=0.189N                 P=0.129N                 P=0.510N                 P=0.121N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  9/50 (18%)               14/50 (28%)              8/49 (16%)               14/50 (28%)     | 
|POLY-3 RATE (b)    |                  9/45.38                  14/47.00                 8/46.40                  14/42.17        | 
|POLY-3 PERCENT (g) |                  19.8%                    29.8%                    17.2%                    33.2%           | 
|TERMINAL (d)       |                  6/32 (19%)               11/35 (31%)              7/39 (18%)               11/28 (39%)     | 
|FIRST INCIDENCE    |                  561                      638                      666                      634             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.083                  P=0.247                  P=0.353N                 P=0.096         | 
|POLY 3             |                  P=0.154                  P=0.193                  P=0.480N                 P=0.117         | 
|POLY 1.5           |                  P=0.186                  P=0.184                  P=0.497N                 P=0.139         | 
|POLY 6             |                  P=0.120                  P=0.206                  P=0.456N                 P=0.092         | 
|LOGISTIC REGRESSION|                  P=0.118                  P=0.198                  P=0.490N                 P=0.105         | 
|COCH-ARM / FISHERS |                  P=0.233                  P=0.171                  P=0.518N                 P=0.171         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                1/49 (2%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  0/46.53                  1/46.14                  2/41.70         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     2.2%                     4.8%            | 
|TERMINAL (d)       |                  0/32 (0%)                0/35 (0%)                1/39 (3%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      734 (T)                  708             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.062                  (e)                      P=0.539                  P=0.206         | 
|POLY 3             |                  P=0.085                  (e)                      P=0.507                  P=0.223         | 
|POLY 1.5           |                  P=0.090                  (e)                      P=0.502                  P=0.229         | 
|POLY 6             |                  P=0.078                  (e)                      P=0.514                  P=0.214         | 
|LOGISTIC REGRESSION|                  P=0.068                  (e)                      P=0.539                  P=0.211         | 
|COCH-ARM / FISHERS |                  P=0.098                  (e)                      P=0.495                  P=0.247         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  21/50 (42%)              26/50 (52%)              29/49 (59%)              29/50 (58%)     | 
|POLY-3 RATE (b)    |                  21/46.95                 26/47.15                 29/46.85                 29/45.24        | 
|POLY-3 PERCENT (g) |                  44.7%                    55.2%                    61.9%                    64.1%           | 
|TERMINAL (d)       |                  13/32 (41%)              21/35 (60%)              26/39 (67%)              18/28 (64%)     | 
|FIRST INCIDENCE    |                  359                      638                      617                      492             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.017 *                P=0.365                  P=0.308                  P=0.039 *       | 
|POLY 3             |                  P=0.078                  P=0.207                  P=0.068                  P=0.043 *       | 
|POLY 1.5           |                  P=0.102                  P=0.208                  P=0.064                  P=0.056         | 
|POLY 6             |                  P=0.057                  P=0.212                  P=0.075                  P=0.032 *       | 
|LOGISTIC REGRESSION|                  P=0.070                  P=0.243                  P=0.080                  P=0.069         | 
|COCH-ARM / FISHERS |                  P=0.143                  P=0.212                  P=0.065                  P=0.081         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Proteinosis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  11/50 (22%)              16/50 (32%)              15/49 (31%)              23/50 (46%)     | 
|POLY-3 RATE (b)    |                  11/45.13                 16/46.76                 15/46.19                 23/43.02        | 
|POLY-3 PERCENT (g) |                  24.4%                    34.2%                    32.5%                    53.5%           | 
|TERMINAL (d)       |                  9/32 (28%)               13/35 (37%)              14/39 (36%)              18/28 (64%)     | 
|FIRST INCIDENCE    |                  561                      708                      722                      590             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P=0.273                  P=0.450                  P=0.002 **      | 
|POLY 3             |                  P=0.004 **               P=0.209                  P=0.265                  P=0.003 **      | 
|POLY 1.5           |                  P=0.006 **               P=0.199                  P=0.248                  P=0.005 **      | 
|POLY 6             |                  P=0.002 **               P=0.225                  P=0.291                  P=0.002 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.245                  P=0.330                  P=0.003 **      | 
|COCH-ARM / FISHERS |                  P=0.011 *                P=0.184                  P=0.228                  P=0.010 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  16/50 (32%)              24/50 (48%)              23/49 (47%)              28/50 (56%)     | 
|POLY-3 RATE (b)    |                  16/45.52                 24/47.12                 23/46.85                 28/44.51        | 
|POLY-3 PERCENT (g) |                  35.2%                    50.9%                    49.1%                    62.9%           | 
|TERMINAL (d)       |                  10/32 (31%)              20/35 (57%)              20/39 (51%)              19/28 (68%)     | 
|FIRST INCIDENCE    |                  652                      638                      617                      492             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.003 **               P=0.160                  P=0.310                  P=0.005 **      | 
|POLY 3             |                  P=0.017 *                P=0.089                  P=0.123                  P=0.005 **      | 
|POLY 1.5           |                  P=0.024 *                P=0.084                  P=0.109                  P=0.008 **      | 
|POLY 6             |                  P=0.011 *                P=0.096                  P=0.143                  P=0.003 **      | 
|LOGISTIC REGRESSION|                  P=0.008 **               P=0.115                  P=0.146                  P=0.005 **      | 
|COCH-ARM / FISHERS |                  P=0.038 *                P=0.076                  P=0.094                  P=0.013 *       | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                6/50 (12%)               6/49 (12%)               4/50 (8%)       | 
|POLY-3 RATE (b)    |                  1/44.57                  6/46.65                  6/46.19                  4/41.71         | 
|POLY-3 PERCENT (g) |                  2.2%                     12.9%                    13.0%                    9.6%            | 
|TERMINAL (d)       |                  0/32 (0%)                4/35 (11%)               5/39 (13%)               3/28 (11%)      | 
|FIRST INCIDENCE    |                  722                      708                      722                      706             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.375                  P=0.085                  P=0.099                  P=0.143         | 
|POLY 3             |                  P=0.456                  P=0.063                  P=0.062                  P=0.158         | 
|POLY 1.5           |                  P=0.485                  P=0.061                  P=0.058                  P=0.168         | 
|POLY 6             |                  P=0.418                  P=0.068                  P=0.067                  P=0.147         | 
|LOGISTIC REGRESSION|                  P=0.380                  P=0.073                  P=0.078                  P=0.139         | 
|COCH-ARM / FISHERS |                  P=0.521                  P=0.056                  P=0.053                  P=0.181         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Bronchial                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/2 (0%)                 2/10 (20%)               0/7 (0%)                 1/5 (20%)       | 
|POLY-3 RATE (b)    |                  0/1.88                   2/8.95                   0/6.49                   1/4.29          | 
|POLY-3 PERCENT (g) |                  0.0%                     22.4%                    0.0%                     23.3%           | 
|TERMINAL (d)       |                  0/0 (0%)                 1/5 (20%)                0/4 (0%)                 1/3 (33%)       | 
|FIRST INCIDENCE    |                  ---                      728                      ---                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.663                  P=0.523                  (e)                      P=1.000         | 
|POLY 3             |                  P=0.594                  P=0.618                  (e)                      P=0.662         | 
|POLY 1.5           |                  P=0.600                  P=0.621                  (e)                      P=0.666         | 
|POLY 6             |                  P=0.591                  P=0.618                  (e)                      P=0.660         | 
|LOGISTIC REGRESSION|                  P=0.649                  P=0.842                  (e)                      P=1.000         | 
|COCH-ARM / FISHERS |                  P=0.614                  P=0.682                  (e)                      P=0.714         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/45 (2%)                2/46 (4%)                0/49 (0%)                1/44 (2%)       | 
|POLY-3 RATE (b)    |                  1/41.74                  2/43.54                  0/46.14                  1/36.55         | 
|POLY-3 PERCENT (g) |                  2.4%                     4.6%                     0.0%                     2.7%            | 
|TERMINAL (d)       |                  0/31 (0%)                1/33 (3%)                0/39 (0%)                0/25 (0%)       | 
|FIRST INCIDENCE    |                  561                      533                      ---                      700             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.635N                 P=0.510                  P=0.500N                 P=0.743         | 
|POLY 3             |                  P=0.631N                 P=0.515                  P=0.480N                 P=0.730         | 
|POLY 1.5           |                  P=0.622N                 P=0.512                  P=0.481N                 P=0.741         | 
|POLY 6             |                  P=0.640N                 P=0.519                  P=0.478N                 P=0.717         | 
|LOGISTIC REGRESSION|                  P=0.511N                 P=0.414                  P=0.498N                 P=0.728N        | 
|COCH-ARM / FISHERS |                  P=0.609N                 P=0.508                  P=0.479N                 P=0.747         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)                5/49 (10%)               1/50 (2%)       | 
|POLY-3 RATE (b)    |                  3/44.52                  1/46.57                  5/46.14                  1/41.73         | 
|POLY-3 PERCENT (g) |                  6.7%                     2.2%                     10.8%                    2.4%            | 
|TERMINAL (d)       |                  3/32 (9%)                0/35 (0%)                5/39 (13%)               0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  722                      734 (T)                  700             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.403N                 P=0.267N                 P=0.468                  P=0.353N        | 
|POLY 3             |                  P=0.366N                 P=0.289N                 P=0.376                  P=0.329N        | 
|POLY 1.5           |                  P=0.342N                 P=0.296N                 P=0.363                  P=0.318N        | 
|POLY 6             |                  P=0.397N                 P=0.280N                 P=0.395                  P=0.342N        | 
|LOGISTIC REGRESSION|                  P=0.404N                 P=0.263N                 P=0.468                  P=0.354N        | 
|COCH-ARM / FISHERS |                  P=0.314N                 P=0.309N                 P=0.346                  P=0.309N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  26/26 (100%)             20/20 (100%)             20/20 (100%)             16/17 (94%)     | 
|POLY-3 RATE (b)    |                  26/26.00                 20/20.00                 20/20.00                 16/17.00        | 
|POLY-3 PERCENT (g) |                  100.0%                   100.0%                   100.0%                   94.1%           | 
|TERMINAL (d)       |                  18/18 (100%)             14/14 (100%)             17/17 (100%)             10/11 (91%)     | 
|FIRST INCIDENCE    |                  525                      706                      349                      478             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.467N                 (e)                      (e)                      P=0.361N        | 
|POLY 3             |                  P=0.179N                 (e)                      (e)                      P=0.415N        | 
|POLY 1.5           |                  P=0.179N                 (e)                      (e)                      P=0.415N        | 
|POLY 6             |                  P=0.179N                 (e)                      (e)                      P=0.415N        | 
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.179N                 (e)                      (e)                      P=0.395N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                4/48 (8%)                3/49 (6%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  1/44.57                  4/45.08                  3/46.14                  1/41.09         | 
|POLY-3 PERCENT (g) |                  2.2%                     8.9%                     6.5%                     2.4%            | 
|TERMINAL (d)       |                  0/32 (0%)                4/35 (11%)               3/39 (8%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  722                      734 (T)                  734 (T)                  634             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.394N                 P=0.216                  P=0.379                  P=0.723         | 
|POLY 3             |                  P=0.346N                 P=0.182                  P=0.318                  P=0.742         | 
|POLY 1.5           |                  P=0.331N                 P=0.176                  P=0.309                  P=0.749         | 
|POLY 6             |                  P=0.366N                 P=0.191                  P=0.330                  P=0.735         | 
|LOGISTIC REGRESSION|                  P=0.367N                 P=0.214                  P=0.351                  P=0.760N        | 
|COCH-ARM / FISHERS |                  P=0.311N                 P=0.168                  P=0.301                  P=0.747         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                5/48 (10%)               7/49 (14%)               3/49 (6%)       | 
|POLY-3 RATE (b)    |                  3/44.64                  5/45.08                  7/46.30                  3/41.85         | 
|POLY-3 PERCENT (g) |                  6.7%                     11.1%                    15.1%                    7.2%            | 
|TERMINAL (d)       |                  1/32 (3%)                5/35 (14%)               6/39 (15%)               0/28 (0%)       | 
|FIRST INCIDENCE    |                  716                      734 (T)                  694                      538             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.516N                 P=0.416                  P=0.245                  P=0.597         | 
|POLY 3             |                  P=0.438N                 P=0.362                  P=0.172                  P=0.633         | 
|POLY 1.5           |                  P=0.416N                 P=0.351                  P=0.162                  P=0.642         | 
|POLY 6             |                  P=0.467N                 P=0.377                  P=0.187                  P=0.622         | 
|LOGISTIC REGRESSION|                  P=0.424N                 P=0.411                  P=0.195                  P=0.650N        | 
|COCH-ARM / FISHERS |                  P=0.387N                 P=0.335                  P=0.151                  P=0.651         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Goblet Cell                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                1/48 (2%)                5/49 (10%)               2/49 (4%)       | 
|POLY-3 RATE (b)    |                  1/44.52                  1/45.08                  5/46.30                  2/41.34         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.2%                     10.8%                    4.8%            | 
|TERMINAL (d)       |                  1/32 (3%)                1/35 (3%)                4/39 (10%)               1/28 (4%)       | 
|FIRST INCIDENCE    |                  734 (T)                  734 (T)                  694                      538             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.421                  P=0.742N                 P=0.151                  P=0.469         | 
|POLY 3             |                  P=0.452                  P=0.758N                 P=0.111                  P=0.474         | 
|POLY 1.5           |                  P=0.475                  P=0.758                  P=0.105                  P=0.483         | 
|POLY 6             |                  P=0.420                  P=0.751N                 P=0.119                  P=0.463         | 
|LOGISTIC REGRESSION|                  P=0.490                  P=0.742N                 P=0.124                  P=0.514         | 
|COCH-ARM / FISHERS |                  P=0.504                  P=0.742                  P=0.098                  P=0.492         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/48 (2%)                1/49 (2%)                3/49 (6%)       | 
|POLY-3 RATE (b)    |                  3/44.82                  1/45.08                  1/46.19                  3/40.74         | 
|POLY-3 PERCENT (g) |                  6.7%                     2.2%                     2.2%                     7.4%            | 
|TERMINAL (d)       |                  2/32 (6%)                1/35 (3%)                0/39 (0%)                3/28 (11%)      | 
|FIRST INCIDENCE    |                  652                      734 (T)                  722                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.292                  P=0.285N                 P=0.252N                 P=0.592         | 
|POLY 3             |                  P=0.343                  P=0.303N                 P=0.295N                 P=0.618         | 
|POLY 1.5           |                  P=0.363                  P=0.310N                 P=0.303N                 P=0.634         | 
|POLY 6             |                  P=0.320                  P=0.294N                 P=0.284N                 P=0.596         | 
|LOGISTIC REGRESSION|                  P=0.318                  P=0.309N                 P=0.307N                 P=0.600         | 
|COCH-ARM / FISHERS |                  P=0.388                  P=0.324N                 P=0.316N                 P=0.651         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                1/48 (2%)                1/49 (2%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  1/45.08                  1/46.14                  2/41.22         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.2%                     2.2%                     4.9%            | 
|TERMINAL (d)       |                  0/32 (0%)                1/35 (3%)                1/39 (3%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  ---                      734 (T)                  734 (T)                  590             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.164                  P=0.518                  P=0.539                  P=0.215         | 
|POLY 3             |                  P=0.195                  P=0.502                  P=0.507                  P=0.220         | 
|POLY 1.5           |                  P=0.203                  P=0.498                  P=0.502                  P=0.226         | 
|POLY 6             |                  P=0.184                  P=0.509                  P=0.514                  P=0.213         | 
|LOGISTIC REGRESSION|                  P=0.220                  P=0.518                  P=0.539                  P=0.248         | 
|COCH-ARM / FISHERS |                  P=0.214                  P=0.490                  P=0.495                  P=0.242         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/48 (4%)                2/49 (4%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  1/44.60                  2/45.08                  2/46.14                  1/40.89         | 
|POLY-3 PERCENT (g) |                  2.2%                     4.4%                     4.3%                     2.5%            | 
|TERMINAL (d)       |                  0/32 (0%)                2/35 (6%)                2/39 (5%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  716                      734 (T)                  734 (T)                  694             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.597N                 P=0.533                  P=0.558                  P=0.723         | 
|POLY 3             |                  P=0.549N                 P=0.504                  P=0.512                  P=0.741         | 
|POLY 1.5           |                  P=0.533N                 P=0.496                  P=0.504                  P=0.748         | 
|POLY 6             |                  P=0.568N                 P=0.514                  P=0.523                  P=0.733         | 
|LOGISTIC REGRESSION|                  P=0.582N                 P=0.527                  P=0.535                  P=0.748         | 
|COCH-ARM / FISHERS |                  P=0.514N                 P=0.485                  P=0.492                  P=0.747         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Pharyngeal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/1 (0%)                 0/0 (0%)                 0/0 (0%)                 2/2 (100%)      | 
|POLY-3 RATE (b)    |                  0/0.93                   0/0.00                   0/0.00                   2/2.00          | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     100.0%          | 
|TERMINAL (d)       |                  0/0 (0%)                 0/0 (0%)                 0/0 (0%)                 1/1 (100%)      | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      492             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.183                  (e)                      (e)                      P=0.468         | 
|POLY 3             |                  (e)                      (e)                      (e)                      P=1.000         | 
|POLY 1.5           |                  (e)                      (e)                      (e)                      P=1.000         | 
|POLY 6             |                  (e)                      (e)                      (e)                      P=1.000         | 
|LOGISTIC REGRESSION|                  P=0.317                  (e)                      (e)                      P=0.448         | 
|COCH-ARM / FISHERS |                  P=0.224                  (e)                      (e)                      P=0.333         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                4/50 (8%)                6/49 (12%)               3/50 (6%)       | 
|POLY-3 RATE (b)    |                  3/44.52                  4/46.53                  6/46.40                  3/42.69         | 
|POLY-3 PERCENT (g) |                  6.7%                     8.6%                     12.9%                    7.0%            | 
|TERMINAL (d)       |                  3/32 (9%)                4/35 (11%)               5/39 (13%)               1/28 (4%)       | 
|FIRST INCIDENCE    |                  734 (T)                  734 (T)                  665                      561             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.586N                 P=0.549                  P=0.343                  P=0.613         | 
|POLY 3             |                  P=0.513N                 P=0.524                  P=0.263                  P=0.643         | 
|POLY 1.5           |                  P=0.492N                 P=0.514                  P=0.249                  P=0.652         | 
|POLY 6             |                  P=0.540N                 P=0.537                  P=0.282                  P=0.632         | 
|LOGISTIC REGRESSION|                  P=0.490N                 P=0.549                  P=0.284                  P=0.645N        | 
|COCH-ARM / FISHERS |                  P=0.466N                 P=0.500                  P=0.233                  P=0.661N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                4/49 (8%)                3/49 (6%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/44.57                  4/45.81                  3/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  2.2%                     8.7%                     6.5%                     0.0%            | 
|TERMINAL (d)       |                  0/32 (0%)                4/35 (11%)               3/39 (8%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  722                      734 (T)                  734 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.167N                 P=0.216                  P=0.379                  P=0.533N        | 
|POLY 3             |                  P=0.149N                 P=0.187                  P=0.318                  P=0.514N        | 
|POLY 1.5           |                  P=0.138N                 P=0.181                  P=0.309                  P=0.507N        | 
|POLY 6             |                  P=0.163N                 P=0.195                  P=0.330                  P=0.522N        | 
|LOGISTIC REGRESSION|                  P=0.171N                 P=0.215                  P=0.351                  P=0.525N        | 
|COCH-ARM / FISHERS |                  P=0.127N                 P=0.175                  P=0.301                  P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/49 (0%)                0/49 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.57                  0/45.81                  0/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  4.5%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                0/35 (0%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  722                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.344N                 P=0.209N                 P=0.198N                 P=0.273N        | 
|POLY 3             |                  P=0.323N                 P=0.231N                 P=0.230N                 P=0.253N        | 
|POLY 1.5           |                  P=0.316N                 P=0.235N                 P=0.235N                 P=0.246N        | 
|POLY 6             |                  P=0.331N                 P=0.225N                 P=0.222N                 P=0.262N        | 
|LOGISTIC REGRESSION|                  P=0.337N                 P=0.218N                 P=0.214N                 P=0.269N        | 
|COCH-ARM / FISHERS |                  P=0.307N                 P=0.253N                 P=0.253N                 P=0.247N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/50 (14%)               9/49 (18%)               8/49 (16%)               5/50 (10%)      | 
|POLY-3 RATE (b)    |                  7/45.03                  9/45.97                  8/46.80                  5/42.08         | 
|POLY-3 PERCENT (g) |                  15.6%                    19.6%                    17.1%                    11.9%           | 
|TERMINAL (d)       |                  5/32 (16%)               7/35 (20%)               6/39 (15%)               4/28 (14%)      | 
|FIRST INCIDENCE    |                  666                      706                      617                      590             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.356N                 P=0.473                  P=0.585N                 P=0.479N        | 
|POLY 3             |                  P=0.271N                 P=0.409                  P=0.532                  P=0.427N        | 
|POLY 1.5           |                  P=0.242N                 P=0.396                  P=0.511                  P=0.405N        | 
|POLY 6             |                  P=0.313N                 P=0.428                  P=0.561                  P=0.458N        | 
|LOGISTIC REGRESSION|                  P=0.269N                 P=0.435                  P=0.500                  P=0.432N        | 
|COCH-ARM / FISHERS |                  P=0.207N                 P=0.376                  P=0.483                  P=0.380N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  15/20 (75%)              17/25 (68%)              23/25 (92%)              27/28 (96%)     | 
|POLY-3 RATE (b)    |                  15/18.82                 17/24.66                 23/25.00                 27/27.30        | 
|POLY-3 PERCENT (g) |                  79.7%                    69.0%                    92.0%                    98.9%           | 
|TERMINAL (d)       |                  11/13 (85%)              13/20 (65%)              20/22 (91%)              19/19 (100%)    | 
|FIRST INCIDENCE    |                  561                      708                      617                      589             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.002 **               P=0.252N                 P=0.582N                 P=0.044 *       | 
|POLY 3             |                  P=0.005 **               P=0.326N                 P=0.227                  P=0.028 *       | 
|POLY 1.5           |                  P=0.006 **               P=0.355N                 P=0.186                  P=0.029 *       | 
|POLY 6             |                  P=0.005 **               P=0.305N                 P=0.271                  P=0.029 *       | 
|LOGISTIC REGRESSION|                  P=0.006 **               P=0.278N                 P=0.223                  P=0.039 *       | 
|COCH-ARM / FISHERS |                  P=0.011 *                P=0.429N                 P=0.126                  P=0.039 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura: Mesothelium                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/20 (10%)               7/25 (28%)               8/25 (32%)               2/28 (7%)       | 
|POLY-3 RATE (b)    |                  2/18.17                  7/24.38                  8/24.34                  2/25.65         | 
|POLY-3 PERCENT (g) |                  11.0%                    28.7%                    32.9%                    7.8%            | 
|TERMINAL (d)       |                  0/13 (0%)                7/20 (35%)               7/22 (32%)               0/19 (0%)       | 
|FIRST INCIDENCE    |                  652                      734 (T)                  722                      634             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.166N                 P=0.185                  P=0.151                  P=0.629         | 
|POLY 3             |                  P=0.095N                 P=0.154                  P=0.096                  P=0.566N        | 
|POLY 1.5           |                  P=0.090N                 P=0.146                  P=0.089                  P=0.564N        | 
|POLY 6             |                  P=0.102N                 P=0.161                  P=0.101                  P=0.571N        | 
|LOGISTIC REGRESSION|                  P=0.102N                 P=0.156                  P=0.098                  P=0.590N        | 
|COCH-ARM / FISHERS |                  P=0.093N                 P=0.130                  P=0.078                  P=0.558N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                0/49 (0%)                0/49 (0%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  1/44.52                  0/45.79                  0/46.14                  3/42.51         | 
|POLY-3 PERCENT (g) |                  2.3%                     0.0%                     0.0%                     7.1%            | 
|TERMINAL (d)       |                  1/32 (3%)                0/35 (0%)                0/39 (0%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  734 (T)                  ---                      ---                      561             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.032 *                P=0.482N                 P=0.461N                 P=0.267         | 
|POLY 3             |                  P=0.042 *                P=0.494N                 P=0.493N                 P=0.288         | 
|POLY 1.5           |                  P=0.045 *                P=0.498N                 P=0.498N                 P=0.296         | 
|POLY 6             |                  P=0.039 *                P=0.489N                 P=0.486N                 P=0.279         | 
|LOGISTIC REGRESSION|                  P=0.070                  (e)                      (e)                      P=0.327         | 
|COCH-ARM / FISHERS |                  P=0.050                  P=0.505N                 P=0.505N                 P=0.309         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                0/49 (0%)                1/49 (2%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/44.78                  0/45.79                  1/46.19                  2/42.08         | 
|POLY-3 PERCENT (g) |                  2.2%                     0.0%                     2.2%                     4.8%            | 
|TERMINAL (d)       |                  0/32 (0%)                0/35 (0%)                0/39 (0%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  666                      ---                      722                      589             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.184                  P=0.495N                 P=0.731N                 P=0.456         | 
|POLY 3             |                  P=0.217                  P=0.496N                 P=0.754N                 P=0.478         | 
|POLY 1.5           |                  P=0.228                  P=0.499N                 P=0.759N                 P=0.488         | 
|POLY 6             |                  P=0.203                  P=0.491N                 P=0.747N                 P=0.465         | 
|LOGISTIC REGRESSION|                  P=0.276                  P=0.537N                 P=0.750                  P=0.524         | 
|COCH-ARM / FISHERS |                  P=0.242                  P=0.505N                 P=0.747                  P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                0/49 (0%)                0/49 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/44.91                  0/45.79                  0/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  6.7%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                0/35 (0%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  639                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.216N                 P=0.108N                 P=0.100N                 P=0.155N        | 
|POLY 3             |                  P=0.198N                 P=0.115N                 P=0.114N                 P=0.133N        | 
|POLY 1.5           |                  P=0.192N                 P=0.118N                 P=0.118N                 P=0.126N        | 
|POLY 6             |                  P=0.206N                 P=0.111N                 P=0.109N                 P=0.142N        | 
|LOGISTIC REGRESSION|                  P=0.179N                 P=0.128N                 P=0.128N                 P=0.123N        | 
|COCH-ARM / FISHERS |                  P=0.186N                 P=0.125N                 P=0.125N                 P=0.121N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                2/47 (4%)                1/49 (2%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.95                  2/44.79                  1/47.04                  0/40.74         | 
|POLY-3 PERCENT (g) |                  4.5%                     4.5%                     2.1%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                1/35 (3%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  609                      728                      349                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.183N                 P=0.659N                 P=0.475N                 P=0.273N        | 
|POLY 3             |                  P=0.177N                 P=0.693                  P=0.484N                 P=0.260N        | 
|POLY 1.5           |                  P=0.168N                 P=0.684                  P=0.493N                 P=0.251N        | 
|POLY 6             |                  P=0.188N                 P=0.684N                 P=0.474N                 P=0.270N        | 
|LOGISTIC REGRESSION|                  P=0.109N                 P=0.657                  P=0.585N                 P=0.229N        | 
|COCH-ARM / FISHERS |                  P=0.155N                 P=0.668                  P=0.508N                 P=0.253N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  15/50 (30%)              7/49 (14%)               6/49 (12%)               6/50 (12%)      | 
|POLY-3 RATE (b)    |                  15/44.90                 7/46.33                  6/46.30                  6/41.60         | 
|POLY-3 PERCENT (g) |                  33.4%                    15.1%                    13.0%                    14.4%           | 
|TERMINAL (d)       |                  12/32 (38%)              5/35 (14%)               5/39 (13%)               6/28 (21%)      | 
|FIRST INCIDENCE    |                  666                      613                      694                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.183N                 P=0.029N*                P=0.008N**               P=0.051N        | 
|POLY 3             |                  P=0.128N                 P=0.034N*                P=0.017N*                P=0.032N*       | 
|POLY 1.5           |                  P=0.107N                 P=0.039N*                P=0.020N*                P=0.027N*       | 
|POLY 6             |                  P=0.161N                 P=0.027N*                P=0.013N*                P=0.041N*       | 
|LOGISTIC REGRESSION|                  P=0.162N                 P=0.032N*                P=0.012N*                P=0.047N*       | 
|COCH-ARM / FISHERS |                  P=0.086N                 P=0.050N                 P=0.027N*                P=0.024N*       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                3/49 (6%)                0/49 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  3/45.81                  0/46.14                  1/41.70         | 
|POLY-3 PERCENT (g) |                  0.0%                     6.6%                     0.0%                     2.4%            | 
|TERMINAL (d)       |                  0/32 (0%)                3/35 (9%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  ---                      734 (T)                  ---                      708             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.691                  P=0.137                  (e)                      P=0.464         | 
|POLY 3             |                  P=0.634N                 P=0.124                  (e)                      P=0.487         | 
|POLY 1.5           |                  P=0.629N                 P=0.120                  (e)                      P=0.493         | 
|POLY 6             |                  P=0.640N                 P=0.129                  (e)                      P=0.479         | 
|LOGISTIC REGRESSION|                  P=0.687N                 P=0.137                  (e)                      P=0.487         | 
|COCH-ARM / FISHERS |                  P=0.620N                 P=0.117                  (e)                      P=0.500         | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
                                                                                                                                   
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).