https://ntp.niehs.nih.gov/go/3696

TDMS Study 93026-07 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 08/28/01       
EXPERIMENT: 93026 TEST: 07                                                                                     TIME: 09:21:58       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 91-17-8         
------------------------------------------------------------------------------------------------------------------------------------
                                                            FINAL#1/RATS                                                            
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE 002    CONTROL                                                                       
                                       INCLUDE 004    25 PPM                                                                        
                                       INCLUDE 007    100 PPM                                                                       
                                       INCLUDE 009    400 PPM                                                                       
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                         DECALIN                                        DATE: 08/28/01       
EXPERIMENT: 93026 TEST: 07                                                                                     TIME: 09:21:58       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C93026       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 91-17-8         
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     DECALIN                                                                                      
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Brain                                  Hemorrhage                                                                                   
Eye                                    Atrophy                                                                                      
Eye: Lens                              Cataract                                                                                     
Kidney                                 Nephropathy Chronic                                                                          
Kidney: Pelvis                         Mineralization                                                                               
Larynx                                 Foreign Body                                                                                 
                                       Inflammation                                                                                 
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
                                       Proteinosis                                                                                  
Lung: Interstitium                     Fibrosis                                                                                     
Pleura                                 Inflammation Chronic                                                                         
Spleen                                 Fibrosis                                                                                     
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                      DECALIN     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                0/48 (0%)                2/49 (4%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  3/44.73                  0/45.50                  2/46.14                  2/40.74         | 
|POLY-3 PERCENT (g) |                  6.7%                     0.0%                     4.3%                     4.9%            | 
|TERMINAL (d)       |                  2/32 (6%)                0/35 (0%)                2/39 (5%)                2/28 (7%)       | 
|FIRST INCIDENCE    |                  680                      ---                      734 (T)                  734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.486                  P=0.107N                 P=0.420N                 P=0.558N        | 
|POLY 3             |                  P=0.510                  P=0.116N                 P=0.486N                 P=0.543N        | 
|POLY 1.5           |                  P=0.533                  P=0.120N                 P=0.496N                 P=0.527N        | 
|POLY 6             |                  P=0.480                  P=0.110N                 P=0.472N                 P=0.563N        | 
|LOGISTIC REGRESSION|                  P=0.486                  P=0.118N                 P=0.472N                 P=0.566N        | 
|COCH-ARM / FISHERS |                  P=0.565                  P=0.129N                 P=0.510N                 P=0.510N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/50 (14%)               7/48 (15%)               11/49 (22%)              8/49 (16%)      | 
|POLY-3 RATE (b)    |                  7/44.73                  7/45.91                  11/46.14                 8/41.55         | 
|POLY-3 PERCENT (g) |                  15.7%                    15.3%                    23.8%                    19.3%           | 
|TERMINAL (d)       |                  6/32 (19%)               4/35 (11%)               11/39 (28%)              5/28 (18%)      | 
|FIRST INCIDENCE    |                  680                      638                      734 (T)                  634             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.309                  P=0.536N                 P=0.367                  P=0.389         | 
|POLY 3             |                  P=0.405                  P=0.593N                 P=0.237                  P=0.438         | 
|POLY 1.5           |                  P=0.446                  P=0.613                  P=0.222                  P=0.458         | 
|POLY 6             |                  P=0.357                  P=0.566N                 P=0.258                  P=0.415         | 
|LOGISTIC REGRESSION|                  P=0.348                  P=0.585N                 P=0.309                  P=0.403         | 
|COCH-ARM / FISHERS |                  P=0.501                  P=0.581                  P=0.204                  P=0.483         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                2/48 (4%)                0/49 (0%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  3/44.85                  2/45.50                  0/46.14                  0/40.74         | 
|POLY-3 PERCENT (g) |                  6.7%                     4.4%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                2/35 (6%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  666                      734 (T)                  ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.121N                 P=0.464N                 P=0.103N                 P=0.160N        | 
|POLY 3             |                  P=0.109N                 P=0.493N                 P=0.114N                 P=0.136N        | 
|POLY 1.5           |                  P=0.104N                 P=0.503N                 P=0.117N                 P=0.130N        | 
|POLY 6             |                  P=0.115N                 P=0.482N                 P=0.109N                 P=0.146N        | 
|LOGISTIC REGRESSION|                  P=0.105N                 P=0.498N                 P=0.124N                 P=0.132N        | 
|COCH-ARM / FISHERS |                  P=0.098N                 P=0.520N                 P=0.125N                 P=0.125N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               5/49 (10%)               6/49 (12%)               3/50 (6%)       | 
|POLY-3 RATE (b)    |                  6/46.18                  5/45.84                  6/46.58                  3/42.76         | 
|POLY-3 PERCENT (g) |                  13.0%                    10.9%                    12.9%                    7.0%            | 
|TERMINAL (d)       |                  2/32 (6%)                4/35 (11%)               4/39 (10%)               0/28 (0%)       | 
|FIRST INCIDENCE    |                  525                      728                      665                      538             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.309N                 P=0.448N                 P=0.527N                 P=0.311N        | 
|POLY 3             |                  P=0.254N                 P=0.505N                 P=0.615N                 P=0.281N        | 
|POLY 1.5           |                  P=0.232N                 P=0.508N                 P=0.617                  P=0.264N        | 
|POLY 6             |                  P=0.283N                 P=0.500N                 P=0.600N                 P=0.304N        | 
|LOGISTIC REGRESSION|                  P=0.156N                 P=0.570N                 P=0.554                  P=0.175N        | 
|COCH-ARM / FISHERS |                  P=0.203N                 P=0.514N                 P=0.606                  P=0.243N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                1/49 (2%)                3/49 (6%)                6/50 (12%)      | 
|POLY-3 RATE (b)    |                  1/44.52                  1/46.08                  3/47.21                  6/43.72         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.2%                     6.4%                     13.7%           | 
|TERMINAL (d)       |                  1/32 (3%)                0/35 (0%)                1/39 (3%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  663                      349                      492             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.008 **               P=0.745N                 P=0.351                  P=0.048 *       | 
|POLY 3             |                  P=0.011 *                P=0.753N                 P=0.327                  P=0.052         | 
|POLY 1.5           |                  P=0.013 *                P=0.758N                 P=0.315                  P=0.054         | 
|POLY 6             |                  P=0.010 *                P=0.746N                 P=0.341                  P=0.051         | 
|LOGISTIC REGRESSION|                  P=0.040 *                P=0.753                  P=0.237                  P=0.073         | 
|COCH-ARM / FISHERS |                  P=0.015 *                P=0.747                  P=0.301                  P=0.056         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/48 (4%)                3/49 (6%)                2/49 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/43.41                  3/45.92                  2/46.14                  1/41.60         | 
|POLY-3 PERCENT (g) |                  4.6%                     6.5%                     4.3%                     2.4%            | 
|TERMINAL (d)       |                  2/31 (7%)                2/35 (6%)                2/39 (5%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  734 (T)                  708                      734 (T)                  734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.376N                 P=0.558                  P=0.610N                 P=0.536N        | 
|POLY 3             |                  P=0.334N                 P=0.526                  P=0.672N                 P=0.515N        | 
|POLY 1.5           |                  P=0.317N                 P=0.518                  P=0.679N                 P=0.503N        | 
|POLY 6             |                  P=0.354N                 P=0.539                  P=0.660N                 P=0.529N        | 
|LOGISTIC REGRESSION|                  P=0.379N                 P=0.555                  P=0.610N                 P=0.536N        | 
|COCH-ARM / FISHERS |                  P=0.293N                 P=0.510                  P=0.684N                 P=0.485N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/48 (6%)                3/49 (6%)                1/49 (2%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  3/43.66                  3/45.84                  1/46.14                  3/41.60         | 
|POLY-3 PERCENT (g) |                  6.9%                     6.6%                     2.2%                     7.2%            | 
|TERMINAL (d)       |                  2/31 (7%)                2/35 (6%)                1/39 (3%)                3/28 (11%)      | 
|FIRST INCIDENCE    |                  666                      728                      734 (T)                  734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.476                  P=0.610N                 P=0.242N                 P=0.609         | 
|POLY 3             |                  P=0.537                  P=0.640N                 P=0.286N                 P=0.640         | 
|POLY 1.5           |                  P=0.557                  P=0.646N                 P=0.292N                 P=0.657         | 
|POLY 6             |                  P=0.511                  P=0.629N                 P=0.276N                 P=0.619         | 
|LOGISTIC REGRESSION|                  P=0.487                  P=0.632N                 P=0.288N                 P=0.617         | 
|COCH-ARM / FISHERS |                  P=0.586                  P=0.651N                 P=0.301N                 P=0.641N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/1 (0%)                 2/2 (100%)               0/5 (0%)                 0/4 (0%)        | 
|POLY-3 RATE (b)    |                  0/1.00                   2/2.00                   0/4.75                   0/3.46          | 
|POLY-3 PERCENT (g) |                  0.0%                     100.0%                   0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/1 (0%)                 0/0 (0%)                 0/4 (0%)                 0/3 (0%)        | 
|FIRST INCIDENCE    |                  ---                      638                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.434N                 P=0.253                  (e)                      (e)             | 
|POLY 3             |                  P<0.001N**               P=1.000N                 (e)                      (e)             | 
|POLY 1.5           |                  P<0.001N**               P=1.000N                 (e)                      (e)             | 
|POLY 6             |                  P<0.001N**               P=1.000N                 (e)                      (e)             | 
|LOGISTIC REGRESSION|                  P=0.129N                 (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.221N                 P=0.333                  (e)                      (e)             | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Lens                                                                                                                        | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/1 (100%)               0/2 (0%)                 3/5 (60%)                2/4 (50%)       | 
|POLY-3 RATE (b)    |                  1/1.00                   0/1.39                   3/5.00                   2/3.46          | 
|POLY-3 PERCENT (g) |                  100.0%                   0.0%                     60.0%                    57.8%           | 
|TERMINAL (d)       |                  1/1 (100%)               0/0 (0%)                 2/4 (50%)                2/3 (67%)       | 
|FIRST INCIDENCE    |                  734 (T)                  ---                      666                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.683N                 P=1.000N                 P=0.743                  P=0.718N        | 
|POLY 3             |                  P=0.710                  P<0.001N**               P=0.631N                 P=0.652N        | 
|POLY 1.5           |                  P=0.690                  P<0.001N**               P=0.631N                 P=0.618N        | 
|POLY 6             |                  P=0.700N                 P=0.574N                 P=0.631N                 P=0.691N        | 
|LOGISTIC REGRESSION|                  P=0.732                  (e)                      (e)                      P=0.718N        | 
|COCH-ARM / FISHERS |                  P=0.674                  P=0.333N                 P=0.667N                 P=0.600N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)                1/49 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.52                  2/46.62                  1/46.35                  0/41.60         | 
|POLY-3 PERCENT (g) |                  4.5%                     4.3%                     2.2%                     0.0%            | 
|TERMINAL (d)       |                  2/32 (6%)                0/35 (0%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  722                      680                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.192N                 P=0.642N                 P=0.443N                 P=0.268N        | 
|POLY 3             |                  P=0.175N                 P=0.677N                 P=0.486N                 P=0.252N        | 
|POLY 1.5           |                  P=0.167N                 P=0.684N                 P=0.495N                 P=0.245N        | 
|POLY 6             |                  P=0.185N                 P=0.668N                 P=0.473N                 P=0.262N        | 
|LOGISTIC REGRESSION|                  P=0.171N                 P=0.661N                 P=0.494N                 (e)             | 
|COCH-ARM / FISHERS |                  P=0.156N                 P=0.691N                 P=0.508N                 P=0.247N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/46 (4%)                1/49 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/44.52                  2/43.79                  1/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  2.3%                     4.6%                     2.2%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                2/35 (6%)                1/39 (3%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  734 (T)                  734 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.275N                 P=0.531                  P=0.717N                 P=0.527N        | 
|POLY 3             |                  P=0.251N                 P=0.494                  P=0.753N                 P=0.514N        | 
|POLY 1.5           |                  P=0.242N                 P=0.485                  P=0.758N                 P=0.507N        | 
|POLY 6             |                  P=0.262N                 P=0.507                  P=0.745N                 P=0.522N        | 
|LOGISTIC REGRESSION|                  P=0.275N                 P=0.531                  P=0.717N                 (e)             | 
|COCH-ARM / FISHERS |                  P=0.231N                 P=0.468                  P=0.747                  P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy Chronic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  43/50 (86%)              45/46 (98%)              48/49 (98%)              48/50 (96%)     | 
|POLY-3 RATE (b)    |                  43/47.48                 45/46.00                 48/48.11                 48/49.14        | 
|POLY-3 PERCENT (g) |                  90.6%                    97.8%                    99.8%                    97.7%           | 
|TERMINAL (d)       |                  31/32 (97%)              34/35 (97%)              39/39 (100%)             28/28 (100%)    | 
|FIRST INCIDENCE    |                  561                      533                      617                      492             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.004 **               P=0.421N                 P=0.343N                 P=0.042 *       | 
|POLY 3             |                  P=0.245                  P=0.122                  P=0.029 *                P=0.114         | 
|POLY 1.5           |                  P=0.231                  P=0.076                  P=0.024 *                P=0.094         | 
|POLY 6             |                  P=0.273                  P=0.218                  P=0.052                  P=0.156         | 
|LOGISTIC REGRESSION|                  P=0.057                  P=0.110                  P=0.068                  P=0.027 *       | 
|COCH-ARM / FISHERS |                  P=0.223                  P=0.039 *                P=0.032 *                P=0.080         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex, Renal Tubule                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                4/46 (9%)                4/49 (8%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/44.52                  4/43.79                  4/46.19                  2/41.60         | 
|POLY-3 PERCENT (g) |                  2.3%                     9.1%                     8.7%                     4.8%            | 
|TERMINAL (d)       |                  1/32 (3%)                4/35 (11%)               3/39 (8%)                2/28 (7%)       | 
|FIRST INCIDENCE    |                  734 (T)                  734 (T)                  722                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.617N                 P=0.206                  P=0.245                  P=0.453         | 
|POLY 3             |                  P=0.537N                 P=0.173                  P=0.190                  P=0.476         | 
|POLY 1.5           |                  P=0.514N                 P=0.166                  P=0.182                  P=0.487         | 
|POLY 6             |                  P=0.567N                 P=0.184                  P=0.201                  P=0.462         | 
|LOGISTIC REGRESSION|                  P=0.621                  P=0.206                  P=0.220                  P=0.453         | 
|COCH-ARM / FISHERS |                  P=0.485N                 P=0.156                  P=0.175                  P=0.500         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                2/46 (4%)                4/49 (8%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  3/44.95                  2/43.79                  4/46.14                  4/41.92         | 
|POLY-3 PERCENT (g) |                  6.7%                     4.6%                     8.7%                     9.5%            | 
|TERMINAL (d)       |                  1/32 (3%)                2/35 (6%)                4/39 (10%)               3/28 (11%)      | 
|FIRST INCIDENCE    |                  666                      734 (T)                  734 (T)                  644             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.254                  P=0.463N                 P=0.588                  P=0.426         | 
|POLY 3             |                  P=0.324                  P=0.512N                 P=0.514                  P=0.462         | 
|POLY 1.5           |                  P=0.351                  P=0.522N                 P=0.503                  P=0.479         | 
|POLY 6             |                  P=0.291                  P=0.499N                 P=0.528                  P=0.439         | 
|LOGISTIC REGRESSION|                  P=0.315                  P=0.534N                 P=0.514                  P=0.472         | 
|COCH-ARM / FISHERS |                  P=0.385                  P=0.540N                 P=0.489                  P=0.500         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  11/50 (22%)              16/46 (35%)              19/49 (39%)              18/50 (36%)     | 
|POLY-3 RATE (b)    |                  11/46.35                 16/43.97                 19/46.19                 18/43.66        | 
|POLY-3 PERCENT (g) |                  23.7%                    36.4%                    41.1%                    41.2%           | 
|TERMINAL (d)       |                  5/32 (16%)               13/35 (37%)              18/39 (46%)              14/28 (50%)     | 
|FIRST INCIDENCE    |                  525                      706                      722                      478             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.048 *                P=0.279                  P=0.176                  P=0.053         | 
|POLY 3             |                  P=0.135                  P=0.138                  P=0.056                  P=0.057         | 
|POLY 1.5           |                  P=0.173                  P=0.132                  P=0.055                  P=0.072         | 
|POLY 6             |                  P=0.092                  P=0.145                  P=0.057                  P=0.039 *       | 
|LOGISTIC REGRESSION|                  P=0.138                  P=0.130                  P=0.066                  P=0.091         | 
|COCH-ARM / FISHERS |                  P=0.224                  P=0.122                  P=0.055                  P=0.093         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis, Transitional Epithelium                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/46 (4%)                2/49 (4%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  2/43.86                  2/46.14                  2/41.60         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.6%                     4.3%                     4.8%            | 
|TERMINAL (d)       |                  0/32 (0%)                0/35 (0%)                2/39 (5%)                2/28 (7%)       | 
|FIRST INCIDENCE    |                  ---                      722                      734 (T)                  734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.300                  P=0.274                  P=0.283                  P=0.209         | 
|POLY 3             |                  P=0.361                  P=0.234                  P=0.245                  P=0.222         | 
|POLY 1.5           |                  P=0.378                  P=0.228                  P=0.240                  P=0.229         | 
|POLY 6             |                  P=0.339                  P=0.242                  P=0.253                  P=0.213         | 
|LOGISTIC REGRESSION|                  P=0.302                  P=0.241                  P=0.283                  P=0.209         | 
|COCH-ARM / FISHERS |                  P=0.400                  P=0.227                  P=0.242                  P=0.247         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                1/49 (2%)                0/49 (0%)                3/48 (6%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  1/45.86                  0/46.14                  3/41.05         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.2%                     0.0%                     7.3%            | 
|TERMINAL (d)       |                  0/32 (0%)                0/35 (0%)                0/39 (0%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  ---                      722                      ---                      580             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.027 *                P=0.538                  (e)                      P=0.110         | 
|POLY 3             |                  P=0.033 *                P=0.506                  (e)                      P=0.104         | 
|POLY 1.5           |                  P=0.035 *                P=0.502                  (e)                      P=0.108         | 
|POLY 6             |                  P=0.031 *                P=0.512                  (e)                      P=0.101         | 
|LOGISTIC REGRESSION|                  P=0.057                  P=0.509                  (e)                      P=0.128         | 
|COCH-ARM / FISHERS |                  P=0.038 *                P=0.495                  (e)                      P=0.114         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/49 (4%)                0/49 (0%)                4/48 (8%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  2/45.86                  0/46.14                  4/41.05         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.4%                     0.0%                     9.7%            | 
|TERMINAL (d)       |                  0/32 (0%)                1/35 (3%)                0/39 (0%)                2/28 (7%)       | 
|FIRST INCIDENCE    |                  ---                      722                      ---                      580             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.018 *                P=0.271                  (e)                      P=0.054         | 
|POLY 3             |                  P=0.024 *                P=0.244                  (e)                      P=0.050         | 
|POLY 1.5           |                  P=0.026 *                P=0.239                  (e)                      P=0.052         | 
|POLY 6             |                  P=0.023 *                P=0.250                  (e)                      P=0.048 *       | 
|LOGISTIC REGRESSION|                  P=0.039 *                P=0.256                  (e)                      P=0.066         | 
|COCH-ARM / FISHERS |                  P=0.029 *                P=0.242                  (e)                      P=0.054         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                4/49 (8%)                2/49 (4%)                2/48 (4%)       | 
|POLY-3 RATE (b)    |                  2/44.70                  4/45.81                  2/46.14                  2/40.17         | 
|POLY-3 PERCENT (g) |                  4.5%                     8.7%                     4.3%                     5.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                4/35 (11%)               2/39 (5%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  688                      734 (T)                  734 (T)                  706             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.550N                 P=0.382                  P=0.630N                 P=0.647         | 
|POLY 3             |                  P=0.506N                 P=0.349                  P=0.682N                 P=0.655         | 
|POLY 1.5           |                  P=0.488N                 P=0.340                  P=0.690N                 P=0.666         | 
|POLY 6             |                  P=0.526N                 P=0.360                  P=0.672N                 P=0.642         | 
|LOGISTIC REGRESSION|                  P=0.553N                 P=0.370                  P=0.676N                 P=0.650         | 
|COCH-ARM / FISHERS |                  P=0.466N                 P=0.329                  P=0.684                  P=0.676         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/48 (4%)                0/49 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  1/44.52                  2/45.08                  0/46.14                  1/41.60         | 
|POLY-3 PERCENT (g) |                  2.3%                     4.4%                     0.0%                     2.4%            | 
|TERMINAL (d)       |                  1/32 (3%)                2/35 (6%)                0/39 (0%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  734 (T)                  734 (T)                  ---                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.662N                 P=0.531                  P=0.461N                 P=0.732         | 
|POLY 3             |                  P=0.605N                 P=0.504                  P=0.493N                 P=0.746         | 
|POLY 1.5           |                  P=0.598N                 P=0.497                  P=0.498N                 P=0.752         | 
|POLY 6             |                  P=0.614N                 P=0.515                  P=0.486N                 P=0.736         | 
|LOGISTIC REGRESSION|                  P=0.662N                 P=0.531                  (e)                      P=0.732         | 
|COCH-ARM / FISHERS |                  P=0.587N                 P=0.485                  P=0.505N                 P=0.753N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/48 (4%)                1/49 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  2/45.08                  1/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.4%                     2.2%                     0.0%            | 
|TERMINAL (d)       |                  0/32 (0%)                2/35 (6%)                1/39 (3%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  ---                      734 (T)                  734 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.411N                 P=0.258                  P=0.539                  (e)             | 
|POLY 3             |                  P=0.379N                 P=0.240                  P=0.507                  (e)             | 
|POLY 1.5           |                  P=0.371N                 P=0.235                  P=0.502                  (e)             | 
|POLY 6             |                  P=0.390N                 P=0.247                  P=0.514                  (e)             | 
|LOGISTIC REGRESSION|                  (e)                      P=0.258                  P=0.539                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.362N                 P=0.237                  P=0.495                  (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/50 (14%)               5/48 (10%)               4/49 (8%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  7/44.52                  5/45.49                  4/46.14                  2/42.27         | 
|POLY-3 PERCENT (g) |                  15.7%                    11.0%                    8.7%                     4.7%            | 
|TERMINAL (d)       |                  7/32 (22%)               4/35 (11%)               4/39 (10%)               0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  613                      734 (T)                  566             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.132N                 P=0.317N                 P=0.156N                 P=0.115N        | 
|POLY 3             |                  P=0.104N                 P=0.364N                 P=0.240N                 P=0.091N        | 
|POLY 1.5           |                  P=0.093N                 P=0.382N                 P=0.255N                 P=0.085N        | 
|POLY 6             |                  P=0.119N                 P=0.337N                 P=0.221N                 P=0.097N        | 
|LOGISTIC REGRESSION|                  P=0.099N                 P=0.348N                 P=0.156N                 P=0.099N        | 
|COCH-ARM / FISHERS |                  P=0.080N                 P=0.409N                 P=0.274N                 P=0.080N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  9/50 (18%)               6/48 (13%)               6/49 (12%)               7/50 (14%)      | 
|POLY-3 RATE (b)    |                  9/45.08                  6/45.21                  6/46.40                  7/42.53         | 
|POLY-3 PERCENT (g) |                  20.0%                    13.3%                    12.9%                    16.5%           | 
|TERMINAL (d)       |                  7/32 (22%)               4/35 (11%)               5/39 (13%)               5/28 (18%)      | 
|FIRST INCIDENCE    |                  652                      706                      665                      538             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.469                  P=0.233N                 P=0.180N                 P=0.510N        | 
|POLY 3             |                  P=0.570N                 P=0.284N                 P=0.266N                 P=0.441N        | 
|POLY 1.5           |                  P=0.537N                 P=0.298N                 P=0.282N                 P=0.419N        | 
|POLY 6             |                  P=0.536                  P=0.266N                 P=0.246N                 P=0.473N        | 
|LOGISTIC REGRESSION|                  P=0.572N                 P=0.266N                 P=0.261N                 P=0.441N        | 
|COCH-ARM / FISHERS |                  P=0.495N                 P=0.318N                 P=0.303N                 P=0.393N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                2/48 (4%)                0/49 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.52                  2/45.12                  0/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  4.5%                     4.4%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/32 (6%)                1/35 (3%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  722                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.178N                 P=0.652N                 P=0.196N                 P=0.268N        | 
|POLY 3             |                  P=0.161N                 P=0.689N                 P=0.229N                 P=0.252N        | 
|POLY 1.5           |                  P=0.156N                 P=0.690                  P=0.235N                 P=0.245N        | 
|POLY 6             |                  P=0.168N                 P=0.677N                 P=0.222N                 P=0.262N        | 
|LOGISTIC REGRESSION|                  P=0.178N                 P=0.656N                 (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.149N                 P=0.676                  P=0.253N                 P=0.247N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                0/48 (0%)                2/49 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/45.23                  0/45.08                  2/47.04                  0/41.60         | 
|POLY-3 PERCENT (g) |                  6.6%                     0.0%                     4.3%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                0/35 (0%)                1/39 (3%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  525                      ---                      349                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.220N                 P=0.110N                 P=0.454N                 P=0.145N        | 
|POLY 3             |                  P=0.218N                 P=0.119N                 P=0.482N                 P=0.134N        | 
|POLY 1.5           |                  P=0.205N                 P=0.122N                 P=0.493N                 P=0.127N        | 
|POLY 6             |                  P=0.237N                 P=0.115N                 P=0.469N                 P=0.144N        | 
|LOGISTIC REGRESSION|                  P=0.137N                 P=0.157N                 P=0.600N                 P=0.106N        | 
|COCH-ARM / FISHERS |                  P=0.189N                 P=0.129N                 P=0.510N                 P=0.121N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  9/50 (18%)               14/50 (28%)              8/49 (16%)               14/50 (28%)     | 
|POLY-3 RATE (b)    |                  9/45.38                  14/47.00                 8/46.40                  14/42.17        | 
|POLY-3 PERCENT (g) |                  19.8%                    29.8%                    17.2%                    33.2%           | 
|TERMINAL (d)       |                  6/32 (19%)               11/35 (31%)              7/39 (18%)               11/28 (39%)     | 
|FIRST INCIDENCE    |                  561                      638                      666                      634             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.083                  P=0.247                  P=0.353N                 P=0.096         | 
|POLY 3             |                  P=0.154                  P=0.193                  P=0.480N                 P=0.117         | 
|POLY 1.5           |                  P=0.186                  P=0.184                  P=0.497N                 P=0.139         | 
|POLY 6             |                  P=0.120                  P=0.206                  P=0.456N                 P=0.092         | 
|LOGISTIC REGRESSION|                  P=0.118                  P=0.198                  P=0.490N                 P=0.105         | 
|COCH-ARM / FISHERS |                  P=0.233                  P=0.171                  P=0.518N                 P=0.171         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                1/49 (2%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  0/46.53                  1/46.14                  2/41.70         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     2.2%                     4.8%            | 
|TERMINAL (d)       |                  0/32 (0%)                0/35 (0%)                1/39 (3%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      734 (T)                  708             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.062                  (e)                      P=0.539                  P=0.206         | 
|POLY 3             |                  P=0.085                  (e)                      P=0.507                  P=0.223         | 
|POLY 1.5           |                  P=0.090                  (e)                      P=0.502                  P=0.229         | 
|POLY 6             |                  P=0.078                  (e)                      P=0.514                  P=0.214         | 
|LOGISTIC REGRESSION|                  P=0.068                  (e)                      P=0.539                  P=0.211         | 
|COCH-ARM / FISHERS |                  P=0.098                  (e)                      P=0.495                  P=0.247         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  21/50 (42%)              26/50 (52%)              29/49 (59%)              29/50 (58%)     | 
|POLY-3 RATE (b)    |                  21/46.95                 26/47.15                 29/46.85                 29/45.24        | 
|POLY-3 PERCENT (g) |                  44.7%                    55.2%                    61.9%                    64.1%           | 
|TERMINAL (d)       |                  13/32 (41%)              21/35 (60%)              26/39 (67%)              18/28 (64%)     | 
|FIRST INCIDENCE    |                  359                      638                      617                      492             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.017 *                P=0.365                  P=0.308                  P=0.039 *       | 
|POLY 3             |                  P=0.078                  P=0.207                  P=0.068                  P=0.043 *       | 
|POLY 1.5           |                  P=0.102                  P=0.208                  P=0.064                  P=0.056         | 
|POLY 6             |                  P=0.057                  P=0.212                  P=0.075                  P=0.032 *       | 
|LOGISTIC REGRESSION|                  P=0.070                  P=0.243                  P=0.080                  P=0.069         | 
|COCH-ARM / FISHERS |                  P=0.143                  P=0.212                  P=0.065                  P=0.081         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Proteinosis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  11/50 (22%)              16/50 (32%)              15/49 (31%)              23/50 (46%)     | 
|POLY-3 RATE (b)    |                  11/45.13                 16/46.76                 15/46.19                 23/43.02        | 
|POLY-3 PERCENT (g) |                  24.4%                    34.2%                    32.5%                    53.5%           | 
|TERMINAL (d)       |                  9/32 (28%)               13/35 (37%)              14/39 (36%)              18/28 (64%)     | 
|FIRST INCIDENCE    |                  561                      708                      722                      590             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001 **               P=0.273                  P=0.450                  P=0.002 **      | 
|POLY 3             |                  P=0.004 **               P=0.209                  P=0.265                  P=0.003 **      | 
|POLY 1.5           |                  P=0.006 **               P=0.199                  P=0.248                  P=0.005 **      | 
|POLY 6             |                  P=0.002 **               P=0.225                  P=0.291                  P=0.002 **      | 
|LOGISTIC REGRESSION|                  P<0.001 **               P=0.245                  P=0.330                  P=0.003 **      | 
|COCH-ARM / FISHERS |                  P=0.011 *                P=0.184                  P=0.228                  P=0.010 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  16/50 (32%)              24/50 (48%)              23/49 (47%)              28/50 (56%)     | 
|POLY-3 RATE (b)    |                  16/45.52                 24/47.12                 23/46.85                 28/44.51        | 
|POLY-3 PERCENT (g) |                  35.2%                    50.9%                    49.1%                    62.9%           | 
|TERMINAL (d)       |                  10/32 (31%)              20/35 (57%)              20/39 (51%)              19/28 (68%)     | 
|FIRST INCIDENCE    |                  652                      638                      617                      492             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.003 **               P=0.160                  P=0.310                  P=0.005 **      | 
|POLY 3             |                  P=0.017 *                P=0.089                  P=0.123                  P=0.005 **      | 
|POLY 1.5           |                  P=0.024 *                P=0.084                  P=0.109                  P=0.008 **      | 
|POLY 6             |                  P=0.011 *                P=0.096                  P=0.143                  P=0.003 **      | 
|LOGISTIC REGRESSION|                  P=0.008 **               P=0.115                  P=0.146                  P=0.005 **      | 
|COCH-ARM / FISHERS |                  P=0.038 *                P=0.076                  P=0.094                  P=0.013 *       | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                6/50 (12%)               6/49 (12%)               4/50 (8%)       | 
|POLY-3 RATE (b)    |                  1/44.57                  6/46.65                  6/46.19                  4/41.71         | 
|POLY-3 PERCENT (g) |                  2.2%                     12.9%                    13.0%                    9.6%            | 
|TERMINAL (d)       |                  0/32 (0%)                4/35 (11%)               5/39 (13%)               3/28 (11%)      | 
|FIRST INCIDENCE    |                  722                      708                      722                      706             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.375                  P=0.085                  P=0.099                  P=0.143         | 
|POLY 3             |                  P=0.456                  P=0.063                  P=0.062                  P=0.158         | 
|POLY 1.5           |                  P=0.485                  P=0.061                  P=0.058                  P=0.168         | 
|POLY 6             |                  P=0.418                  P=0.068                  P=0.067                  P=0.147         | 
|LOGISTIC REGRESSION|                  P=0.380                  P=0.073                  P=0.078                  P=0.139         | 
|COCH-ARM / FISHERS |                  P=0.521                  P=0.056                  P=0.053                  P=0.181         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Bronchial                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/2 (0%)                 2/10 (20%)               0/7 (0%)                 1/5 (20%)       | 
|POLY-3 RATE (b)    |                  0/1.88                   2/8.95                   0/6.49                   1/4.29          | 
|POLY-3 PERCENT (g) |                  0.0%                     22.4%                    0.0%                     23.3%           | 
|TERMINAL (d)       |                  0/0 (0%)                 1/5 (20%)                0/4 (0%)                 1/3 (33%)       | 
|FIRST INCIDENCE    |                  ---                      728                      ---                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.663                  P=0.523                  (e)                      P=1.000         | 
|POLY 3             |                  P=0.594                  P=0.618                  (e)                      P=0.662         | 
|POLY 1.5           |                  P=0.600                  P=0.621                  (e)                      P=0.666         | 
|POLY 6             |                  P=0.591                  P=0.618                  (e)                      P=0.660         | 
|LOGISTIC REGRESSION|                  P=0.649                  P=0.842                  (e)                      P=1.000         | 
|COCH-ARM / FISHERS |                  P=0.614                  P=0.682                  (e)                      P=0.714         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/45 (2%)                2/46 (4%)                0/49 (0%)                1/44 (2%)       | 
|POLY-3 RATE (b)    |                  1/41.74                  2/43.54                  0/46.14                  1/36.55         | 
|POLY-3 PERCENT (g) |                  2.4%                     4.6%                     0.0%                     2.7%            | 
|TERMINAL (d)       |                  0/31 (0%)                1/33 (3%)                0/39 (0%)                0/25 (0%)       | 
|FIRST INCIDENCE    |                  561                      533                      ---                      700             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.635N                 P=0.510                  P=0.500N                 P=0.743         | 
|POLY 3             |                  P=0.631N                 P=0.515                  P=0.480N                 P=0.730         | 
|POLY 1.5           |                  P=0.622N                 P=0.512                  P=0.481N                 P=0.741         | 
|POLY 6             |                  P=0.640N                 P=0.519                  P=0.478N                 P=0.717         | 
|LOGISTIC REGRESSION|                  P=0.511N                 P=0.414                  P=0.498N                 P=0.728N        | 
|COCH-ARM / FISHERS |                  P=0.609N                 P=0.508                  P=0.479N                 P=0.747         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)                5/49 (10%)               1/50 (2%)       | 
|POLY-3 RATE (b)    |                  3/44.52                  1/46.57                  5/46.14                  1/41.73         | 
|POLY-3 PERCENT (g) |                  6.7%                     2.2%                     10.8%                    2.4%            | 
|TERMINAL (d)       |                  3/32 (9%)                0/35 (0%)                5/39 (13%)               0/28 (0%)       | 
|FIRST INCIDENCE    |                  734 (T)                  722                      734 (T)                  700             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.403N                 P=0.267N                 P=0.468                  P=0.353N        | 
|POLY 3             |                  P=0.366N                 P=0.289N                 P=0.376                  P=0.329N        | 
|POLY 1.5           |                  P=0.342N                 P=0.296N                 P=0.363                  P=0.318N        | 
|POLY 6             |                  P=0.397N                 P=0.280N                 P=0.395                  P=0.342N        | 
|LOGISTIC REGRESSION|                  P=0.404N                 P=0.263N                 P=0.468                  P=0.354N        | 
|COCH-ARM / FISHERS |                  P=0.314N                 P=0.309N                 P=0.346                  P=0.309N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  26/26 (100%)             20/20 (100%)             20/20 (100%)             16/17 (94%)     | 
|POLY-3 RATE (b)    |                  26/26.00                 20/20.00                 20/20.00                 16/17.00        | 
|POLY-3 PERCENT (g) |                  100.0%                   100.0%                   100.0%                   94.1%           | 
|TERMINAL (d)       |                  18/18 (100%)             14/14 (100%)             17/17 (100%)             10/11 (91%)     | 
|FIRST INCIDENCE    |                  525                      706                      349                      478             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.467N                 (e)                      (e)                      P=0.361N        | 
|POLY 3             |                  P=0.179N                 (e)                      (e)                      P=0.415N        | 
|POLY 1.5           |                  P=0.179N                 (e)                      (e)                      P=0.415N        | 
|POLY 6             |                  P=0.179N                 (e)                      (e)                      P=0.415N        | 
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.179N                 (e)                      (e)                      P=0.395N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                4/48 (8%)                3/49 (6%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  1/44.57                  4/45.08                  3/46.14                  1/41.09         | 
|POLY-3 PERCENT (g) |                  2.2%                     8.9%                     6.5%                     2.4%            | 
|TERMINAL (d)       |                  0/32 (0%)                4/35 (11%)               3/39 (8%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  722                      734 (T)                  734 (T)                  634             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.394N                 P=0.216                  P=0.379                  P=0.723         | 
|POLY 3             |                  P=0.346N                 P=0.182                  P=0.318                  P=0.742         | 
|POLY 1.5           |                  P=0.331N                 P=0.176                  P=0.309                  P=0.749         | 
|POLY 6             |                  P=0.366N                 P=0.191                  P=0.330                  P=0.735         | 
|LOGISTIC REGRESSION|                  P=0.367N                 P=0.214                  P=0.351                  P=0.760N        | 
|COCH-ARM / FISHERS |                  P=0.311N                 P=0.168                  P=0.301                  P=0.747         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                5/48 (10%)               7/49 (14%)               3/49 (6%)       | 
|POLY-3 RATE (b)    |                  3/44.64                  5/45.08                  7/46.30                  3/41.85         | 
|POLY-3 PERCENT (g) |                  6.7%                     11.1%                    15.1%                    7.2%            | 
|TERMINAL (d)       |                  1/32 (3%)                5/35 (14%)               6/39 (15%)               0/28 (0%)       | 
|FIRST INCIDENCE    |                  716                      734 (T)                  694                      538             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.516N                 P=0.416                  P=0.245                  P=0.597         | 
|POLY 3             |                  P=0.438N                 P=0.362                  P=0.172                  P=0.633         | 
|POLY 1.5           |                  P=0.416N                 P=0.351                  P=0.162                  P=0.642         | 
|POLY 6             |                  P=0.467N                 P=0.377                  P=0.187                  P=0.622         | 
|LOGISTIC REGRESSION|                  P=0.424N                 P=0.411                  P=0.195                  P=0.650N        | 
|COCH-ARM / FISHERS |                  P=0.387N                 P=0.335                  P=0.151                  P=0.651         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Goblet Cell                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                1/48 (2%)                5/49 (10%)               2/49 (4%)       | 
|POLY-3 RATE (b)    |                  1/44.52                  1/45.08                  5/46.30                  2/41.34         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.2%                     10.8%                    4.8%            | 
|TERMINAL (d)       |                  1/32 (3%)                1/35 (3%)                4/39 (10%)               1/28 (4%)       | 
|FIRST INCIDENCE    |                  734 (T)                  734 (T)                  694                      538             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.421                  P=0.742N                 P=0.151                  P=0.469         | 
|POLY 3             |                  P=0.452                  P=0.758N                 P=0.111                  P=0.474         | 
|POLY 1.5           |                  P=0.475                  P=0.758                  P=0.105                  P=0.483         | 
|POLY 6             |                  P=0.420                  P=0.751N                 P=0.119                  P=0.463         | 
|LOGISTIC REGRESSION|                  P=0.490                  P=0.742N                 P=0.124                  P=0.514         | 
|COCH-ARM / FISHERS |                  P=0.504                  P=0.742                  P=0.098                  P=0.492         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/48 (2%)                1/49 (2%)                3/49 (6%)       | 
|POLY-3 RATE (b)    |                  3/44.82                  1/45.08                  1/46.19                  3/40.74         | 
|POLY-3 PERCENT (g) |                  6.7%                     2.2%                     2.2%                     7.4%            | 
|TERMINAL (d)       |                  2/32 (6%)                1/35 (3%)                0/39 (0%)                3/28 (11%)      | 
|FIRST INCIDENCE    |                  652                      734 (T)                  722                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.292                  P=0.285N                 P=0.252N                 P=0.592         | 
|POLY 3             |                  P=0.343                  P=0.303N                 P=0.295N                 P=0.618         | 
|POLY 1.5           |                  P=0.363                  P=0.310N                 P=0.303N                 P=0.634         | 
|POLY 6             |                  P=0.320                  P=0.294N                 P=0.284N                 P=0.596         | 
|LOGISTIC REGRESSION|                  P=0.318                  P=0.309N                 P=0.307N                 P=0.600         | 
|COCH-ARM / FISHERS |                  P=0.388                  P=0.324N                 P=0.316N                 P=0.651         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                1/48 (2%)                1/49 (2%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  1/45.08                  1/46.14                  2/41.22         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.2%                     2.2%                     4.9%            | 
|TERMINAL (d)       |                  0/32 (0%)                1/35 (3%)                1/39 (3%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  ---                      734 (T)                  734 (T)                  590             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.164                  P=0.518                  P=0.539                  P=0.215         | 
|POLY 3             |                  P=0.195                  P=0.502                  P=0.507                  P=0.220         | 
|POLY 1.5           |                  P=0.203                  P=0.498                  P=0.502                  P=0.226         | 
|POLY 6             |                  P=0.184                  P=0.509                  P=0.514                  P=0.213         | 
|LOGISTIC REGRESSION|                  P=0.220                  P=0.518                  P=0.539                  P=0.248         | 
|COCH-ARM / FISHERS |                  P=0.214                  P=0.490                  P=0.495                  P=0.242         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/48 (4%)                2/49 (4%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  1/44.60                  2/45.08                  2/46.14                  1/40.89         | 
|POLY-3 PERCENT (g) |                  2.2%                     4.4%                     4.3%                     2.5%            | 
|TERMINAL (d)       |                  0/32 (0%)                2/35 (6%)                2/39 (5%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  716                      734 (T)                  734 (T)                  694             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.597N                 P=0.533                  P=0.558                  P=0.723         | 
|POLY 3             |                  P=0.549N                 P=0.504                  P=0.512                  P=0.741         | 
|POLY 1.5           |                  P=0.533N                 P=0.496                  P=0.504                  P=0.748         | 
|POLY 6             |                  P=0.568N                 P=0.514                  P=0.523                  P=0.733         | 
|LOGISTIC REGRESSION|                  P=0.582N                 P=0.527                  P=0.535                  P=0.748         | 
|COCH-ARM / FISHERS |                  P=0.514N                 P=0.485                  P=0.492                  P=0.747         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Pharyngeal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/1 (0%)                 0/0 (0%)                 0/0 (0%)                 2/2 (100%)      | 
|POLY-3 RATE (b)    |                  0/0.93                   0/0.00                   0/0.00                   2/2.00          | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     100.0%          | 
|TERMINAL (d)       |                  0/0 (0%)                 0/0 (0%)                 0/0 (0%)                 1/1 (100%)      | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      492             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.183                  (e)                      (e)                      P=0.468         | 
|POLY 3             |                  (e)                      (e)                      (e)                      P=1.000         | 
|POLY 1.5           |                  (e)                      (e)                      (e)                      P=1.000         | 
|POLY 6             |                  (e)                      (e)                      (e)                      P=1.000         | 
|LOGISTIC REGRESSION|                  P=0.317                  (e)                      (e)                      P=0.448         | 
|COCH-ARM / FISHERS |                  P=0.224                  (e)                      (e)                      P=0.333         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                4/50 (8%)                6/49 (12%)               3/50 (6%)       | 
|POLY-3 RATE (b)    |                  3/44.52                  4/46.53                  6/46.40                  3/42.69         | 
|POLY-3 PERCENT (g) |                  6.7%                     8.6%                     12.9%                    7.0%            | 
|TERMINAL (d)       |                  3/32 (9%)                4/35 (11%)               5/39 (13%)               1/28 (4%)       | 
|FIRST INCIDENCE    |                  734 (T)                  734 (T)                  665                      561             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.586N                 P=0.549                  P=0.343                  P=0.613         | 
|POLY 3             |                  P=0.513N                 P=0.524                  P=0.263                  P=0.643         | 
|POLY 1.5           |                  P=0.492N                 P=0.514                  P=0.249                  P=0.652         | 
|POLY 6             |                  P=0.540N                 P=0.537                  P=0.282                  P=0.632         | 
|LOGISTIC REGRESSION|                  P=0.490N                 P=0.549                  P=0.284                  P=0.645N        | 
|COCH-ARM / FISHERS |                  P=0.466N                 P=0.500                  P=0.233                  P=0.661N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                4/49 (8%)                3/49 (6%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/44.57                  4/45.81                  3/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  2.2%                     8.7%                     6.5%                     0.0%            | 
|TERMINAL (d)       |                  0/32 (0%)                4/35 (11%)               3/39 (8%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  722                      734 (T)                  734 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.167N                 P=0.216                  P=0.379                  P=0.533N        | 
|POLY 3             |                  P=0.149N                 P=0.187                  P=0.318                  P=0.514N        | 
|POLY 1.5           |                  P=0.138N                 P=0.181                  P=0.309                  P=0.507N        | 
|POLY 6             |                  P=0.163N                 P=0.195                  P=0.330                  P=0.522N        | 
|LOGISTIC REGRESSION|                  P=0.171N                 P=0.215                  P=0.351                  P=0.525N        | 
|COCH-ARM / FISHERS |                  P=0.127N                 P=0.175                  P=0.301                  P=0.500N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/49 (0%)                0/49 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.57                  0/45.81                  0/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  4.5%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                0/35 (0%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  722                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.344N                 P=0.209N                 P=0.198N                 P=0.273N        | 
|POLY 3             |                  P=0.323N                 P=0.231N                 P=0.230N                 P=0.253N        | 
|POLY 1.5           |                  P=0.316N                 P=0.235N                 P=0.235N                 P=0.246N        | 
|POLY 6             |                  P=0.331N                 P=0.225N                 P=0.222N                 P=0.262N        | 
|LOGISTIC REGRESSION|                  P=0.337N                 P=0.218N                 P=0.214N                 P=0.269N        | 
|COCH-ARM / FISHERS |                  P=0.307N                 P=0.253N                 P=0.253N                 P=0.247N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/50 (14%)               9/49 (18%)               8/49 (16%)               5/50 (10%)      | 
|POLY-3 RATE (b)    |                  7/45.03                  9/45.97                  8/46.80                  5/42.08         | 
|POLY-3 PERCENT (g) |                  15.6%                    19.6%                    17.1%                    11.9%           | 
|TERMINAL (d)       |                  5/32 (16%)               7/35 (20%)               6/39 (15%)               4/28 (14%)      | 
|FIRST INCIDENCE    |                  666                      706                      617                      590             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.356N                 P=0.473                  P=0.585N                 P=0.479N        | 
|POLY 3             |                  P=0.271N                 P=0.409                  P=0.532                  P=0.427N        | 
|POLY 1.5           |                  P=0.242N                 P=0.396                  P=0.511                  P=0.405N        | 
|POLY 6             |                  P=0.313N                 P=0.428                  P=0.561                  P=0.458N        | 
|LOGISTIC REGRESSION|                  P=0.269N                 P=0.435                  P=0.500                  P=0.432N        | 
|COCH-ARM / FISHERS |                  P=0.207N                 P=0.376                  P=0.483                  P=0.380N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  15/20 (75%)              17/25 (68%)              23/25 (92%)              27/28 (96%)     | 
|POLY-3 RATE (b)    |                  15/18.82                 17/24.66                 23/25.00                 27/27.30        | 
|POLY-3 PERCENT (g) |                  79.7%                    69.0%                    92.0%                    98.9%           | 
|TERMINAL (d)       |                  11/13 (85%)              13/20 (65%)              20/22 (91%)              19/19 (100%)    | 
|FIRST INCIDENCE    |                  561                      708                      617                      589             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.002 **               P=0.252N                 P=0.582N                 P=0.044 *       | 
|POLY 3             |                  P=0.005 **               P=0.326N                 P=0.227                  P=0.028 *       | 
|POLY 1.5           |                  P=0.006 **               P=0.355N                 P=0.186                  P=0.029 *       | 
|POLY 6             |                  P=0.005 **               P=0.305N                 P=0.271                  P=0.029 *       | 
|LOGISTIC REGRESSION|                  P=0.006 **               P=0.278N                 P=0.223                  P=0.039 *       | 
|COCH-ARM / FISHERS |                  P=0.011 *                P=0.429N                 P=0.126                  P=0.039 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura: Mesothelium                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/20 (10%)               7/25 (28%)               8/25 (32%)               2/28 (7%)       | 
|POLY-3 RATE (b)    |                  2/18.17                  7/24.38                  8/24.34                  2/25.65         | 
|POLY-3 PERCENT (g) |                  11.0%                    28.7%                    32.9%                    7.8%            | 
|TERMINAL (d)       |                  0/13 (0%)                7/20 (35%)               7/22 (32%)               0/19 (0%)       | 
|FIRST INCIDENCE    |                  652                      734 (T)                  722                      634             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.166N                 P=0.185                  P=0.151                  P=0.629         | 
|POLY 3             |                  P=0.095N                 P=0.154                  P=0.096                  P=0.566N        | 
|POLY 1.5           |                  P=0.090N                 P=0.146                  P=0.089                  P=0.564N        | 
|POLY 6             |                  P=0.102N                 P=0.161                  P=0.101                  P=0.571N        | 
|LOGISTIC REGRESSION|                  P=0.102N                 P=0.156                  P=0.098                  P=0.590N        | 
|COCH-ARM / FISHERS |                  P=0.093N                 P=0.130                  P=0.078                  P=0.558N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                0/49 (0%)                0/49 (0%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  1/44.52                  0/45.79                  0/46.14                  3/42.51         | 
|POLY-3 PERCENT (g) |                  2.3%                     0.0%                     0.0%                     7.1%            | 
|TERMINAL (d)       |                  1/32 (3%)                0/35 (0%)                0/39 (0%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  734 (T)                  ---                      ---                      561             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.032 *                P=0.482N                 P=0.461N                 P=0.267         | 
|POLY 3             |                  P=0.042 *                P=0.494N                 P=0.493N                 P=0.288         | 
|POLY 1.5           |                  P=0.045 *                P=0.498N                 P=0.498N                 P=0.296         | 
|POLY 6             |                  P=0.039 *                P=0.489N                 P=0.486N                 P=0.279         | 
|LOGISTIC REGRESSION|                  P=0.070                  (e)                      (e)                      P=0.327         | 
|COCH-ARM / FISHERS |                  P=0.050                  P=0.505N                 P=0.505N                 P=0.309         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                0/49 (0%)                1/49 (2%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/44.78                  0/45.79                  1/46.19                  2/42.08         | 
|POLY-3 PERCENT (g) |                  2.2%                     0.0%                     2.2%                     4.8%            | 
|TERMINAL (d)       |                  0/32 (0%)                0/35 (0%)                0/39 (0%)                1/28 (4%)       | 
|FIRST INCIDENCE    |                  666                      ---                      722                      589             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.184                  P=0.495N                 P=0.731N                 P=0.456         | 
|POLY 3             |                  P=0.217                  P=0.496N                 P=0.754N                 P=0.478         | 
|POLY 1.5           |                  P=0.228                  P=0.499N                 P=0.759N                 P=0.488         | 
|POLY 6             |                  P=0.203                  P=0.491N                 P=0.747N                 P=0.465         | 
|LOGISTIC REGRESSION|                  P=0.276                  P=0.537N                 P=0.750                  P=0.524         | 
|COCH-ARM / FISHERS |                  P=0.242                  P=0.505N                 P=0.747                  P=0.500         | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                0/49 (0%)                0/49 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/44.91                  0/45.79                  0/46.14                  0/41.60         | 
|POLY-3 PERCENT (g) |                  6.7%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                0/35 (0%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  639                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.216N                 P=0.108N                 P=0.100N                 P=0.155N        | 
|POLY 3             |                  P=0.198N                 P=0.115N                 P=0.114N                 P=0.133N        | 
|POLY 1.5           |                  P=0.192N                 P=0.118N                 P=0.118N                 P=0.126N        | 
|POLY 6             |                  P=0.206N                 P=0.111N                 P=0.109N                 P=0.142N        | 
|LOGISTIC REGRESSION|                  P=0.179N                 P=0.128N                 P=0.128N                 P=0.123N        | 
|COCH-ARM / FISHERS |                  P=0.186N                 P=0.125N                 P=0.125N                 P=0.121N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                2/47 (4%)                1/49 (2%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.95                  2/44.79                  1/47.04                  0/40.74         | 
|POLY-3 PERCENT (g) |                  4.5%                     4.5%                     2.1%                     0.0%            | 
|TERMINAL (d)       |                  1/32 (3%)                1/35 (3%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  609                      728                      349                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.183N                 P=0.659N                 P=0.475N                 P=0.273N        | 
|POLY 3             |                  P=0.177N                 P=0.693                  P=0.484N                 P=0.260N        | 
|POLY 1.5           |                  P=0.168N                 P=0.684                  P=0.493N                 P=0.251N        | 
|POLY 6             |                  P=0.188N                 P=0.684N                 P=0.474N                 P=0.270N        | 
|LOGISTIC REGRESSION|                  P=0.109N                 P=0.657                  P=0.585N                 P=0.229N        | 
|COCH-ARM / FISHERS |                  P=0.155N                 P=0.668                  P=0.508N                 P=0.253N        | 
|=================================================================================================================================| 
       Date:  08/28/01                           EXPERIMENT: 93026 TEST: 07                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DECALIN      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  15/50 (30%)              7/49 (14%)               6/49 (12%)               6/50 (12%)      | 
|POLY-3 RATE (b)    |                  15/44.90                 7/46.33                  6/46.30                  6/41.60         | 
|POLY-3 PERCENT (g) |                  33.4%                    15.1%                    13.0%                    14.4%           | 
|TERMINAL (d)       |                  12/32 (38%)              5/35 (14%)               5/39 (13%)               6/28 (21%)      | 
|FIRST INCIDENCE    |                  666                      613                      694                      734 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.183N                 P=0.029N*                P=0.008N**               P=0.051N        | 
|POLY 3             |                  P=0.128N                 P=0.034N*                P=0.017N*                P=0.032N*       | 
|POLY 1.5           |                  P=0.107N                 P=0.039N*                P=0.020N*                P=0.027N*       | 
|POLY 6             |                  P=0.161N                 P=0.027N*                P=0.013N*                P=0.041N*       | 
|LOGISTIC REGRESSION|                  P=0.162N                 P=0.032N*                P=0.012N*                P=0.047N*       | 
|COCH-ARM / FISHERS |                  P=0.086N                 P=0.050N                 P=0.027N*                P=0.024N*       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  CONTROL                  25 PPM                   100 PPM                  400 PPM         | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                3/49 (6%)                0/49 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/44.52                  3/45.81                  0/46.14                  1/41.70         | 
|POLY-3 PERCENT (g) |                  0.0%                     6.6%                     0.0%                     2.4%            | 
|TERMINAL (d)       |                  0/32 (0%)                3/35 (9%)                0/39 (0%)                0/28 (0%)       | 
|FIRST INCIDENCE    |                  ---                      734 (T)                  ---                      708             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.691                  P=0.137                  (e)                      P=0.464         | 
|POLY 3             |                  P=0.634N                 P=0.124                  (e)                      P=0.487         | 
|POLY 1.5           |                  P=0.629N                 P=0.120                  (e)                      P=0.493         | 
|POLY 6             |                  P=0.640N                 P=0.129                  (e)                      P=0.479         | 
|LOGISTIC REGRESSION|                  P=0.687N                 P=0.137                  (e)                      P=0.487         | 
|COCH-ARM / FISHERS |                  P=0.620N                 P=0.117                  (e)                      P=0.500         | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).