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TDMS Study 93029-04 Pathology Tables

NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03
Route: DOSED FEED                                                                                                 Time: 07:07:49




       Facility:  National Center for Toxicological Research

       Chemical CAS #:  129-73-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1


NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|             
                                           | 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A     A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large                         | +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rectum, Inflammation, Chronic        |                            3                                             |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A     A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  A     A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         | +  A     A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Hyperplasia, Lymphoid         |                               2                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A     A  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A     A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A     A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X                                                |             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
      Infiltration Cellular, Lymphocytic   |                1                                2                 2      |             
      Inflammation, Chronic Active, Focal  |                               2        1  1  2        2  1  1        2   |             
      Mineralization, Focal                |                                              1                           |             
      Necrosis                             |                2                                                         |             
      Tension Lipidosis                    |                                  2     1              2              1   |             
      Vacuolization Cytoplasmic            |                                  2                             2         |             
      Bile Duct, Cyst                      |                                              3           3               |             
      Oval Cell, Hyperplasia               |                         2                                                |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|             
                                           | 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  A     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                        1                                 |             
      Infiltration Cellular, Lymphocytic   |                1                 1                    2                  |             
      Acinus, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Parotid Gland, Atrophy       |                1                                                         |             
      Acinus, Submandibular Gland, Atrophy |                      2                                                   |             
      Parotid Gland, Infiltration Cellular,|                                                                          |             
           Lymphocytic                     |                1                 1        1           1  1               |             
      Parotid Gland, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                         2|             
      Submandibular Gland, Infiltration    |                                                                          |             
          Cellular, Lymphocytic            |                2  1        2  2  1     2  1     2     1  2        1  2   |             
                                           |__________________________________________________________________________|             
   Stomach                                 | +  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Hyperkeratosis, Focal   |                                                    1                     |             
      Forestomach, Infiltration Cellular,  |                                                                          |             
           Lymphocytic                     |                                                                          |             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Diffuse                         |                                                                          |             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                    2                     |             
      Glandular, Infiltration Cellular,    |                                                                          |             
           Lymphocytic                     |                                                                2         |             
      Glandular, Ulcer                     |                                                                2         |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +     A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|             
                                           | 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                                                          |             
      Atrium Left, Thrombosis              |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Accessory Adrenal Cortical   |                                                                          |             
          Nodule                           |             X                                      X                     |             
      Cortex, Cyst                         |                                                                      X   |             
      Cortex, Hyperplasia, Focal           |                                                       1                  |             
      Cortex, Hypertrophy, Focal           |                                                       1                  |             
      Cortex, Subcapsular, Hyperplasia     |          2     2  2  2  2  2  2  2     2  2  1  2  2  2  2  2  2  2     2|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  A     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                         2                          1                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Cyst                |                2     2                                2                 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           | 1        2  1  2  2  2  1  2  2  2  2  2     2  2  2  2  2  2  2  1  2  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|             
                                           | 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Angiectasis                          |                                                                          |             
      Atrophy                              |             2  2  2     2     1  2  2  2  2  2  2  2  2  1  1  1  1  2  2|             
      Cyst                                 |                         X        X  X              X        X  X  X     X|             
      Hemorrhage                           |                2                                                         |             
      Thrombosis                           |                         3                                                |             
      Bilateral, Cyst                      |                X                                X                        |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis, Focal                   |                                                    3                     |             
      Hyperplasia, Cystic                  |          2  1  4  2  1  4     2  1  2  2  4  2  3     2  4  3  3  2  3  3|             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  A     +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                              2                           |             
      Femoral, Infarct                     |          2                                                               |             
      Myeloid Cell, Hyperplasia            |                      2  2                                                |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Cyst                         |                                                                          |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                3                                                         |             
      Mandibular, Hyperplasia, Lymphoid    |                2                                                         |             
      Mediastinal, Hyperplasia, Lymphoid   |                                     2                                    |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hemorrhage               |                               1                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                1                    3                                    |             
      Renal, Hyperplasia, Lymphoid         |                3                    2                                    |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  A     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|             
                                           | 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Spleen                                  | +  +     A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             3  2     4  3           4                    1     2         |             
      Hyperplasia, Lymphoid                |                3  2              3  3           2     3                  |             
      Proliferation Connective Tissue,     |                                                                          |             
           Focal                           |                                           1                              |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  A     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                                                   |             
      Cyst                                 |                      X                                                   |             
      Ectopic Parathyroid Gland            |                                                       X           X      |             
      Hyperplasia, Lymphoid                |                1                    2                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Face, Ulcer                          |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                   1                                                  1  2|             
      Sternum, Degeneration, Cystic        |                                                                          |             
      Sternum, Fibrous Osteodystrophy      |                      1           1           2        1  1  2  1  1  1  2|             
                                           |__________________________________________________________________________|             
   Bone, Femur                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Mineralization             |          1     1              1        1        1           1  1         |             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|             
                                           | 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thoracic, Axon, Degeneration         |                1                 1                    1                  |             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |          2                                                               |             
      Infiltration Cellular, Histiocytic   |                                                                          |             
      Infiltration Cellular, Lymphocytic   |             2     2  2                       2  2  1  3  2               |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Vein, Thrombosis                     |          3                                                               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Lens, Cataract            |    3        3     3        4                                             |             
      Cornea, Inflammation, Chronic        |                      2                                                   |             
      Lens, Cataract                       | 2        3           1        2                    1                     |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocytic   |                                           1              2               |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|             
                                           | 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                               1                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocytic   |                               3                 2     1  1        1      |             
      Nephropathy                          |                                                    3                     |             
      Papilla, Casts Protein               |                                                 1                        |             
      Pelvis, Dilatation                   |                      4        3                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                            3                                             |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inclusion Body Intracytoplasmic      | 1              1     1              1  1              1           1  1  1|             
      Infiltration Cellular, Lymphocytic   |          1        3     2     1  1     1  1           2  2  1     1  1  1|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
      Polyarteritis                        |                                                          1               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Rectum, Inflammation, Chronic        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
      Ileum, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Basophilic Focus                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                   2      |      2  1.5|
      Infiltration Cellular, Lymphocytic   | 1           2                                            1     1  2      |      8  1.5|
      Inflammation, Chronic Active, Focal  |       2                       1  1     1     2  1     1                  |     15  1.4|
      Mineralization, Focal                |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Tension Lipidosis                    |                2     2        1     2     2     1                        |     10  1.6|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.0|
      Bile Duct, Cyst                      |                                                 1                        |      3  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Oval Cell, Hyperplasia               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   1        |
      Fat, Necrosis, Focal                 |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocytic   |             1     2  1           2                                       |      7  1.4|
      Acinus, Atrophy                      |                                                       1                  |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Acinus, Parotid Gland, Atrophy       |                                                                          |      1  1.0|
      Acinus, Submandibular Gland, Atrophy |                                                                          |      1  2.0|
      Parotid Gland, Infiltration Cellular,|                                                                          |            |
           Lymphocytic                     |             2     1                       1                       2      |      9  1.2|
      Parotid Gland, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                   2      |      2  2.0|
      Submandibular Gland, Infiltration    |                                                                          |            |
          Cellular, Lymphocytic            | 1  1  1  1  2     2  1  2  2  2  2  1  2  1  2  1  2     1  2  2  3      |     33  1.6|
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Forestomach, Hyperkeratosis, Focal   |                                                                          |      1  1.0|
      Forestomach, Infiltration Cellular,  |                                                                          |            |
           Lymphocytic                     |                                                                   2      |      1  2.0|
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Diffuse                         |                                                                3         |      1  3.0|
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                              2           2               |      3  2.0|
      Glandular, Infiltration Cellular,    |                                                                          |            |
           Lymphocytic                     |                                                                          |      1  2.0|
      Glandular, Ulcer                     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Artery, Inflammation, Chronic        |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Polyarteritis                        |                                     3                                    |      1  3.0|
      Atrium Left, Thrombosis              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Cortex, Accessory Adrenal Cortical   |                                                                          |            |
          Nodule                           | X                                                                        |      3     |
      Cortex, Cyst                         |                                                                          |      1     |
      Cortex, Hyperplasia, Focal           |                                                                1         |      2  1.0|
      Cortex, Hypertrophy, Focal           |       2                                                                  |      2  1.5|
      Cortex, Subcapsular, Hyperplasia     | 1  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2      |     42  1.9|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +      |  45        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M      |  42        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  M  M  +  +  +      |  41        |
      Pars Distalis, Hyperplasia, Focal    |                            1                                             |      3  1.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +      |  46        |
      Follicular Cell, Cyst                |                   1                 2                             2      |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Duct, Cyst                           | 1  3  2  1  1  2  2  2  2  2  3     2  2  2  2  2  2  2  2  2  2  2      |     44  1.9|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Angiectasis                          |                         2                                                |      1  2.0|
      Atrophy                              | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2      |     42  1.9|
      Cyst                                 |                   X     X              X  X  X                    X      |     14     |
      Hemorrhage                           |    3                                         1           1               |      4  1.8|
      Thrombosis                           |       3                       3                                          |      3  3.0|
      Bilateral, Cyst                      |    X  X     X              X                                   X         |      7     |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Adenomyosis, Focal                   |                                                                          |      1  3.0|
      Hyperplasia, Cystic                  | 2  2  1  1  1  4  2  3  3  3  2  1  3  2  4  2  2  4  2  3  3     1      |     42  2.4|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Epithelium, Hyperplasia              | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Femoral, Infarct                     |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                2  3      |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Lumbar, Cyst                         |             X                                                            |      1     |
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                                                                   3      |      1  3.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                   2      |      1  2.0|
      Mesenteric, Hemorrhage               |                                                                          |      1  1.0|
      Mesenteric, Hyperplasia, Lymphoid    |             2                             2                       3      |      5  2.2|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Hematopoietic Cell Proliferation     |             1                                   2              3  2      |     11  2.5|
      Hyperplasia, Lymphoid                | 1     2  2        1           2                          2     2  2      |     14  2.1|
      Proliferation Connective Tissue,     |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +      |  43        |
      Atrophy                              |             2                                                            |      2  2.0|
      Cyst                                 |                                     X                                    |      2     |
      Ectopic Parathyroid Gland            |                                           X              X               |      4     |
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Face, Ulcer                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Femur, Fibrous Osteodystrophy        |                   1     3     1        1  1                              |      8  1.4|
      Sternum, Degeneration, Cystic        |                                                                1         |      1  1.0|
      Sternum, Fibrous Osteodystrophy      | 1        1     1  1  1  3  1  1  1     1  1  3  2  2  1  2               |     26  1.4|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cerebrum, Mineralization             |             1        1           1     1  1  1     1              1      |     15  1.0|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Thoracic, Axon, Degeneration         |    1  1              1     1           1     1        1  1  1            |     12  1.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocytic   |                                                       1                  |      1  1.0|
      Infiltration Cellular, Lymphocytic   | 1        2  1                                            2     2         |     13  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Inflammation, Chronic, Focal         |       1                                                                  |      1  1.0|
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |      1  1.0|
      Vein, Thrombosis                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Bilateral, Lens, Cataract            |                                                                          |      4  3.3|
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
      Lens, Cataract                       |                                                                          |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infiltration Cellular, Lymphocytic   |                      1                                   1               |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Glomerulosclerosis                   |                                                                          |      1  1.0|
      Infarct                              |       1                                                        1         |      2  1.0|
      Infiltration Cellular, Lymphocytic   | 1        2  1                    1                                       |      9  1.4|
      Nephropathy                          |                                                                          |      1  3.0|
      Papilla, Casts Protein               |                                                                          |      1  1.0|
      Pelvis, Dilatation                   |                                                                          |      2  3.5|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Inclusion Body Intracytoplasmic      | 1  1        1  1                       1                                 |     14  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    0 PPM                                  | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Infiltration Cellular, Lymphocytic   |    1  1  2     2  1  1  2  1           2  1  1  1  1     1  2     2      |     29  1.4|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    91 PPM                                 | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|             
                                           | 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocytic   |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rectum, Inflammation, Chronic        |                                                          2               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Hyperplasia, Lymphoid         |                         1                                                |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X              X                                          |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |       3     3                                                            |             
      Infiltration Cellular, Lymphocytic   |                                                                          |             
      Inflammation, Chronic Active, Focal  |                   1                 1  1  1  2     1              2      |             
      Tension Lipidosis                    | 1                 1     1  1     1  1  1                                1|             
      Vacuolization Cytoplasmic            |             1                                                            |             
      Bile Duct, Cyst                      |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +                 +                                          |             
      Fat, Necrosis, Focal                 |             2                 2                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    91 PPM                                 | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|             
                                           | 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                       1                  |             
      Infiltration Cellular, Lymphocytic   |          2                    1                                          |             
      Acinus, Atrophy                      |       2     2                                                            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Parotid Gland, Atrophy       |       2     4                                                            |             
      Acinus, Submandibular Gland, Atrophy |             3                                                            |             
      Parotid Gland, Infiltration Cellular,|                                                                          |             
           Lymphocytic                     |    1  2              1  1     1                                          |             
      Submandibular Gland, Infiltration    |                                                                          |             
          Cellular, Lymphocytic            | 2  1  2  1        2     2  2  2     1  1  1  1     2        1  2     2  2|             
                                           |__________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                      2   |             
      Glandular, Infiltration Cellular,    |                                                                          |             
           Lymphocytic                     |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    1                                                  1                  |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Embolus Bacterial             |    4                                                                     |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Acute, Focal           |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    91 PPM                                 | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|             
                                           | 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Accessory Adrenal Cortical   |                                                                          |             
          Nodule                           |                                                          X               |             
      Cortex, Hypertrophy, Focal           |                                                                          |             
      Cortex, Subcapsular, Hyperplasia     | 2     2  1  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2|             
      Medulla, Hyperplasia, Focal          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocytic   |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                 X                        |             
      Follicular Cell, Cyst                |          2     1                    1     2              2  2  1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Duct, Cyst                           |    2  1  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Angiectasis                          |                                                                          |             
      Atrophy                              | 2     2  2  3  1  2  2  2  2  2  2  2  1  2  2  2  3  2     1  2  2  2  1|             
      Cyst                                 | X        X  X                       X  X  X                 X     X  X  X|             
      Hemorrhage                           |                                                    1                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    91 PPM                                 | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|             
                                           | 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Bilateral, Cyst                      |                                              X                 X         |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                           2         |             
      Hyperplasia, Cystic                  | 3     1  4  2  4  4  4  4  2  3  2  2  3  2  2  2  3  3  3  2  2  2  3  4|             
      Thrombosis                           |    4                                                                     |             
      Endometrium, Metaplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   3      |             
      Myeloid Cell, Hyperplasia            |             2                                                            |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                         3|             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    | 2                                                                 2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |    3  4  3  3        2                                   2               |             
      Hyperplasia, Lymphoid                |                                                             2     2      |             
      Infiltration Cellular, Plasma Cell   |             4                                                            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                                                               |             
      Cyst                                 |                                                 X                        |             
      Ectopic Parathyroid Gland            |                                                 X  X        X            |             
      Hyperplasia, Lymphoid                |                                                                      1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    91 PPM                                 | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|             
                                           | 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                                 1                 1      |             
      Sternum, Degeneration, Cystic        |                      1           1           1                           |             
      Sternum, Fibrous Osteodystrophy      |                            1     1     2  1  1     2                     |             
                                           |__________________________________________________________________________|             
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Mineralization             | 1  1           1     1  1        1                                   1  1|             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thoracic, Axon, Degeneration         |             1                                      1                     |             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Crystals                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    91 PPM                                 | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|             
                                           | 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Infiltration Cellular, Histiocytic   |                                                          1               |             
      Infiltration Cellular, Lymphocytic   |             1     2        1                       1                     |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Leukocytosis                         |    3  1                                                                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Lens, Cataract            |    3                                                  1  2     1         |             
      Lens, Cataract                       |                                           3  1                           |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                                                                2         |             
      Infiltration Cellular, Lymphocytic   |       2  2                 1  1     1                    1               |             
      Acinus, Dilatation                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Infiltration Cellular, Lymphocytic   |             1           1                 1                       1      |             
      Nephropathy                          |                         1                          1                     |             
      Glomerulus, Casts Protein            |                                                                          |             
      Pelvis, Dilatation                   |          3                                                               |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |          3                                               2               |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Hypertrophy            |                                                                         1|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    91 PPM                                 | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|             
                                           | 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inclusion Body Intracytoplasmic      | 1                 1     1     1  1  1  2  1  1        1  1  1  1  2  1  2|             
      Infiltration Cellular, Lymphocytic   |    1        2     1                 1     1     1     1           1      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    91 PPM                                 | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |      L     |
                                           | 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infiltration Cellular, Lymphocytic   |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Rectum, Inflammation, Chronic        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +      |  47        |
      Ileum, Hyperplasia, Lymphoid         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Basophilic Focus                     |                                                                          |      2     |
      Clear Cell Focus                     |                                              X                           |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Infiltration Cellular, Lymphocytic   |                         1                                         2      |      2  1.5|
      Inflammation, Chronic Active, Focal  | 1           1  1           2                    1           2            |     13  1.3|
      Tension Lipidosis                    |    1           1                          1                    2         |     12  1.1|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Bile Duct, Cyst                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    91 PPM                                 | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |      L     |
                                           | 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis, Focal                 |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cyst                                 |                   2                                      2               |      2  2.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocytic   | 1     1           1                    1  1           1     1            |      9  1.1|
      Acinus, Atrophy                      |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Acinus, Parotid Gland, Atrophy       |                                                                2         |      3  2.7|
      Acinus, Submandibular Gland, Atrophy |                                                                          |      1  3.0|
      Parotid Gland, Infiltration Cellular,|                                                                          |            |
           Lymphocytic                     |                1           1     1     1                                 |      9  1.1|
      Submandibular Gland, Infiltration    |                                                                          |            |
          Cellular, Lymphocytic            | 2     2  1  2     1        1           1  1  2     2  1  2  1            |     30  1.5|
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           | 2           1                                1                           |      4  1.5|
      Glandular, Infiltration Cellular,    |                                                                          |            |
           Lymphocytic                     |       2                                                                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Foreign Body                         |                                              1                           |      3  1.0|
      Artery, Inflammation, Chronic        |             2                       2                                    |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    91 PPM                                 | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |      L     |
                                           | 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Aorta, Embolus Bacterial             |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       |             1                                                            |      1  1.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cortex, Accessory Adrenal Cortical   |                                                                          |            |
          Nodule                           |                                                                          |      1     |
      Cortex, Hypertrophy, Focal           |                                     1                             3      |      2  2.0|
      Cortex, Subcapsular, Hyperplasia     | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2      |     47  1.9|
      Medulla, Hyperplasia, Focal          |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  M  +  +  +  +  +  +      |  42        |
      Infiltration Cellular, Lymphocytic   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +      |  45        |
      Pars Distalis, Hyperplasia, Focal    |                                              1                           |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ultimobranchial Cyst                 |    X                                                                     |      2     |
      Follicular Cell, Cyst                |          2                                   1              1            |     10  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    91 PPM                                 | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |      L     |
                                           | 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |  46        |
      Inflammation, Chronic                |                            2                                             |      1  2.0|
      Duct, Cyst                           | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2         |     46  1.9|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Abscess                              |                                           X                              |      1     |
      Angiectasis                          |                                                 2                        |      1  2.0|
      Atrophy                              | 1     2  1  1  2  1  1  2  2  2  2  2  2  2  1  2  1  1  2  1  2  1      |     45  1.7|
      Cyst                                 |             X        X  X                                   X  X  X      |     16     |
      Hemorrhage                           |             3                                                            |      2  2.0|
      Bilateral, Cyst                      |    X                                                                     |      3     |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |                            2                 1                           |      4  1.8|
      Hyperplasia, Cystic                  | 2  2  3  3  1  1  3  2  2  3  3  2  1  4  2     3  2  3  2  4  2  2      |     46  2.6|
      Thrombosis                           |                                                                          |      1  4.0|
      Endometrium, Metaplasia              |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Fibrosis                             |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inguinal, Hyperplasia, Lymphoid      |             1                                                            |      1  1.0|
      Mandibular, Hyperplasia, Lymphoid    |             3                                            2               |      3  2.7|
      Mesenteric, Hemorrhage               |                                  2                                       |      1  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    91 PPM                                 | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |      L     |
                                           | 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |                                              2                           |      1  2.0|
      Hematopoietic Cell Proliferation     |    1                                3                             2      |      9  2.6|
      Hyperplasia, Lymphoid                |       1     2                                                            |      4  1.8|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Atrophy                              |                                     2                                    |      2  2.5|
      Cyst                                 |                                                                          |      1     |
      Ectopic Parathyroid Gland            | X                    X                          X  X                     |      7     |
      Hyperplasia, Lymphoid                |             1                                                     2      |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Femur, Fibrous Osteodystrophy        |                                                                          |      2  1.0|
      Sternum, Degeneration, Cystic        |                                                                          |      3  1.0|
      Sternum, Fibrous Osteodystrophy      | 1     1  1     2  1  2  1  1  2     1     2  1     2  2     1            |     21  1.4|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    91 PPM                                 | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |      L     |
                                           | 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cerebrum, Mineralization             | 1        1  1        1     1           1        1  1  1  1               |     18  1.0|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Thoracic, Axon, Degeneration         |             1  1  3           1  1        1  1  1        1               |     11  1.2|
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Crystals                             |                   2                                                      |      1  2.0|
      Infiltration Cellular, Histiocytic   | 1                                                                        |      2  1.0|
      Infiltration Cellular, Lymphocytic   |    3  3  1                                                               |      7  1.7|
      Inflammation, Chronic, Focal         |                      1                                                   |      1  1.0|
      Leukocytosis                         |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                      1                                                   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Bilateral, Lens, Cataract            |                                     3                                    |      5  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    91 PPM                                 | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     |      L     |
                                           | 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|     |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Lens, Cataract                       |          2                                                        1      |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                   1                                                      |      1  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocytic   |       2           2                          2                           |      9  1.6|
      Acinus, Dilatation                   |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +      |  47        |
      Atrophy                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocytic   |                                                                1         |      5  1.0|
      Nephropathy                          |                                                                          |      2  1.0|
      Glomerulus, Casts Protein            | 2                                                                        |      1  2.0|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      2  2.5|
      Renal Tubule, Hyperplasia            |                                     2                                    |      1  2.0|
      Renal Tubule, Hypertrophy            |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inclusion Body Intracytoplasmic      | 1  1     2        1  1  1  1  1        1  1  1  1  2  1  1  2  1         |     33  1.2|
      Infiltration Cellular, Lymphocytic   |    2     1  1     1     1     1        1  1        1  1  1  1  1  1      |     22  1.1|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    204 PPM                                | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Polyarteritis                 |          2                                                               |             
      Colon, Angiectasis                   |                                                 2                        |             
      Rectum, Polyarteritis                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Hyperplasia, Lymphoid         |                                                                   2      |             
      Jejunum, Hyperplasia, Lymphoid       |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus, Single           |                                                                          |             
      Hematopoietic Cell Proliferation     |          1        2                                      4               |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocytic   |                         2        2                                       |             
      Inflammation, Chronic Active, Focal  |                         1  1                 1  1     1           1  1   |             
      Tension Lipidosis                    |                         2  2                                         1   |             
      Bile Duct, Cyst                      |                               2                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    204 PPM                                | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                    1                     |             
      Infiltration Cellular, Lymphocytic   |                                                    1                 1   |             
      Polyarteritis                        |          3                                                               |             
      Acinus, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Parotid Gland, Necrosis,     |                                                                          |             
           Focal                           |                                  2                 1                     |             
      Parotid Gland, Infiltration Cellular,|                                                                          |             
           Lymphocytic                     |                         1     1  1           2     2                     |             
      Parotid Gland, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                         2|             
      Sublingual Gland, Infiltration       |                                                                          |             
          Cellular, Lymphocytic            |                               1                                          |             
      Submandibular Gland, Infiltration    |                                                                          |             
          Cellular, Lymphocytic            |    1     2  1     1  2  1  1  1  2  1  1  2  1  1  2     1  1     1  2   |             
                                           |__________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Foreign Body            |                                                                          |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                      2   |             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |             2                          3           1                 3   |             
      Glandular, Infiltration Cellular,    |                                                                          |             
           Lymphocytic                     |                                                    1                     |             
      Glandular, Polyarteritis             |          2                                                               |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                1         |             
      Artery, Inflammation, Chronic        |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    204 PPM                                | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Cortex, Hypertrophy, Focal|                                                                          |             
      Cortex, Accessory Adrenal Cortical   |                                                                          |             
          Nodule                           |                                                                          |             
      Cortex, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                1                                                         |             
      Cortex, Hyperplasia, Focal           |                                                 2                        |             
      Cortex, Hypertrophy, Focal           |                                                                         3|             
      Cortex, Polyarteritis                |          3                                                               |             
      Cortex, Subcapsular, Hyperplasia     | 1  1     2  2  3  2  2  2  2  1  2  2  2  2  2  2  2  2  2  1  2  2  2  2|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |          3                                                               |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Cyst                |                                                 1     1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    204 PPM                                | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |             2                                                            |             
      Duct, Cyst                           |          2  3  2  2  2     2  2  2  2  1  1  2  2  2  2  2  2     2  2  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |    1     2     2  3  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2   |             
      Cyst                                 |          X     X        X        X        X        X              X     X|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                              1                           |             
      Bilateral, Cyst                      |                                                             X            |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   1      |             
      Hyperplasia, Cystic                  | 1  1     1  1  2  1  2  3  2  3  3  2  2  2  2  2  3  3  2  3  3  2  4  1|             
      Polyarteritis                        |          2                                                               |             
      Thrombosis                           |                                                                          |             
      Stroma, Fibrosis                     |                                                                         3|             
      Stroma, Hyperplasia                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                       3                  |             
      Myeloid Cell, Hyperplasia            |    3           3  4                                                  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hyperplasia, Lymphoid    |                            3                          2        4         |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                       4           2      |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    204 PPM                                | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4  3     1     3  3                                   2  3  2  2  2      |             
      Hyperplasia, Lymphoid                |                         2        3                    2                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                                                               |             
      Cyst                                 |                                                          X               |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    |    +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                                             2     1      |             
      Sternum, Degeneration, Cystic        |                                                                          |             
      Sternum, Fibrous Osteodystrophy      |                                  1        1        1  1     3  2  1      |             
                                           |__________________________________________________________________________|             
   Bone, Femur                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Mineralization             |                1     1  1  1  1  1     1        1  1  1  1               |             
      Cerebrum, Polyarteritis              |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    204 PPM                                | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thoracic, Axon, Degeneration         |                                        1                       1         |             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocytic   |          2        2     3        2           1     2     2               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Lens, Cataract            |                      3     2                             2               |             
      Lens, Cataract                       |                   3                       3                              |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
      Infiltration Cellular, Lymphocytic   |          1     1  1  1        1                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                 1                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    204 PPM                                | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
                                           | 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Infiltration Cellular, Lymphocytic   |    1              1     1     2              1        1  1     1     1   |             
      Nephropathy                          |                                                                          |             
      Polyarteritis                        |          3                                                               |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                      2                                                   |             
      Renal Tubule, Necrosis               | 2                                                                        |             
      Renal Tubule, Pigmentation           |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inclusion Body Intracytoplasmic      |    2     1  2     3     2  1  1  1  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Infiltration Cellular, Lymphocytic   |                      1  1  1  1  2     1           1     1               |             
      Polyarteritis                        |          1                                                               |             
      Submucosa, Edema                     |          3                                                               |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    204 PPM                                | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M      |  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cecum, Polyarteritis                 |                                                                          |      1  2.0|
      Colon, Angiectasis                   |                                                                          |      1  2.0|
      Rectum, Polyarteritis                |                                                    2                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Ileum, Hyperplasia, Lymphoid         |    2                             1                                       |      3  1.7|
      Jejunum, Hyperplasia, Lymphoid       |                                  1                                       |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Clear Cell Focus                     |                X                                                         |      1     |
      Eosinophilic Focus, Single           |                                                          X               |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Infarct                              |             4                                                            |      1  4.0|
      Infiltration Cellular, Lymphocytic   |                                                                          |      2  2.0|
      Inflammation, Chronic Active, Focal  |    1     1     1        1           1     1        2     1  1            |     16  1.1|
      Tension Lipidosis                    |                         1     1  2     1     1                 1         |      9  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    204 PPM                                | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Cyst                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   1        |
      Fat, Necrosis, Focal                 |                                                          1               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocytic   |    1                       1                                             |      4  1.0|
      Polyarteritis                        |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Acinus, Parotid Gland, Necrosis,     |                                                                          |            |
           Focal                           |          1                                                               |      3  1.3|
      Parotid Gland, Infiltration Cellular,|                                                                          |            |
           Lymphocytic                     |             2  2                                               1         |      8  1.5|
      Parotid Gland, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
      Sublingual Gland, Infiltration       |                                                                          |            |
          Cellular, Lymphocytic            |          1                                                               |      2  1.0|
      Submandibular Gland, Infiltration    |                                                                          |            |
          Cellular, Lymphocytic            |    2  2  2  2  3  2     2  1  2  2  2        1  1  2        2  2         |     35  1.6|
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Forestomach, Foreign Body            |                                                       2                  |      1  2.0|
      Forestomach, Inflammation, Chronic   |                                                                          |            |
          Active                           |             2                                                            |      2  2.0|
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |    2        2                                2        3                  |      8  2.3|
      Glandular, Infiltration Cellular,    |                                                                          |            |
           Lymphocytic                     |                                                                          |      1  1.0|
      Glandular, Polyarteritis             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    204 PPM                                | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Foreign Body                         |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic        |    1                                                                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Bilateral, Cortex, Hypertrophy, Focal|             2                                                            |      1  2.0|
      Cortex, Accessory Adrenal Cortical   |                                                                          |            |
          Nodule                           |                                              X                           |      1     |
      Cortex, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                                                                          |      1  1.0|
      Cortex, Hyperplasia, Focal           |                      2                                                   |      2  2.0|
      Cortex, Hypertrophy, Focal           |                                                                          |      1  3.0|
      Cortex, Polyarteritis                |                                                                          |      1  3.0|
      Cortex, Subcapsular, Hyperplasia     | 2  2  2  1  2  2  2  1  2  1  2  2  2  2  2     1  2  2  1  2  2  2      |     46  1.8|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +      |  41        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    204 PPM                                | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +      |  44        |
      Pars Distalis, Hyperplasia, Focal    |    1                                1              2                     |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Polyarteritis                        |                                                                          |      1  3.0|
      Ultimobranchial Cyst                 |                X           X                                             |      2     |
      Follicular Cell, Cyst                |    1                                            1  1           1         |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +      |  44        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Duct, Cyst                           | 2  2  2  2  2  2  1  2  2  2  2  2  1  2  2  1  2     2  2  2     2      |     41  1.9|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Angiectasis                          |                2                                      2                  |      2  2.0|
      Atrophy                              | 2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  1  2  2      |     44  1.9|
      Cyst                                 |    X  X                                X  X  X  X     X  X  X            |     17     |
      Hemorrhage                           |                         1           1                                    |      2  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Bilateral, Cyst                      |             X                                                            |      2     |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Angiectasis                          | 1                                                           2            |      3  1.3|
      Hyperplasia, Cystic                  | 3  2  3  3  2  1  2  4  4  2  3  2  2  4  2  4  2  3  3  1  2  4  3      |     47  2.4|
      Polyarteritis                        |                                                                          |      1  2.0|
      Thrombosis                           |                         3        2                          2            |      3  2.3|
      Stroma, Fibrosis                     |                                                                          |      1  3.0|
      Stroma, Hyperplasia                  |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    204 PPM                                | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Fibrosis                             |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Mandibular, Hyperplasia, Lymphoid    |       3        2           3              2        2                     |      8  2.6|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                       2                  |      1  2.0|
      Mesenteric, Hemorrhage               |                                                       2                  |      1  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                    2                     |      3  2.7|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |          3                                   3                           |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +      |  45        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hematopoietic Cell Proliferation     |    2              1              1     1  2        2  2                  |     17  2.1|
      Hyperplasia, Lymphoid                |                1                       1  2        3        3            |      8  2.1|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |  45        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                      X                                                   |      2     |
      Ectopic Parathyroid Gland            |    X              X     X                    X                           |      4     |
      Hyperplasia, Lymphoid                |       2        1              2                    3                     |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    204 PPM                                | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Femur, Fibrous Osteodystrophy        |                                           3     1  1                     |      5  1.6|
      Sternum, Degeneration, Cystic        |                      1                                                   |      1  1.0|
      Sternum, Fibrous Osteodystrophy      |          1     2  1  1        1  1  1     2  1     2  2           1      |     19  1.4|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cerebrum, Mineralization             |       1  1        1           1           1     1  1  1  1     1         |     21  1.0|
      Cerebrum, Polyarteritis              |    1                                                                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Thoracic, Axon, Degeneration         |    1                    1     1  1        1     1           1            |      9  1.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infiltration Cellular, Lymphocytic   |          1                                                     1         |      9  1.8|
      Alveolar Epithelium, Hyperplasia     |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    204 PPM                                | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Bilateral, Lens, Cataract            |                                                                          |      3  2.3|
      Lens, Cataract                       |             1  1                                                         |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocytic   |    1           2                                      1                  |      8  1.1|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infarct                              |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocytic   |    1        1     1     1           1              2                     |     15  1.1|
      Nephropathy                          | 1           1                                         1                  |      3  1.0|
      Polyarteritis                        |                                                                          |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      1  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Inclusion Body Intracytoplasmic      | 2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2      |     44  1.9|
      Infiltration Cellular, Lymphocytic   |    1  1  2  1  1  1     1  1  1  1     1  2  1  1  3     1               |     24  1.2|
      Polyarteritis                        |                                                                          |      1  1.0|
      Submucosa, Edema                     |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    408 PPM                                | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 2                                                                        |             
      Mucosa, Hyperplasia, Focal           |                                                          1  1            |             
                                           |__________________________________________________________________________|             
   Intestine Large                         | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Colon, Proliferation Connective      |                                                                          |             
          Tissue                           |                                                             2            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | A     +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | A     A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Hyperplasia, Lymphoid         |                                                                          |             
      Jejunum, Hyperplasia, Lymphoid       |                                           2                              |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | A     +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A     +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                          X               |             
      Basophilic Focus, Two                |                                                    X                     |             
      Eosinophilic Focus, Single           |                                                                          |             
      Hematopoietic Cell Proliferation     |          1  1  4                                                         |             
      Infiltration Cellular, Lymphocytic   |                                        2  1           1     1            |             
      Inflammation, Chronic Active, Focal  |             1           1  1  1  2              1                        |             
      Leukocytosis                         |          2                                                               |             
      Tension Lipidosis                    |                         1                       1        1               |             
      Bile Duct, Cyst                      |                                                                          |             
      Serosa, Fibrosis                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    408 PPM                                | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Fat, Necrosis, Focal                 |                                           2                              |             
                                           |__________________________________________________________________________|             
   Pancreas                                | A     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Infiltration Cellular, Lymphocytic   |                1                                   2                     |             
      Acinus, Atrophy                      |             2                                                            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Parotid Gland, Atrophy       |                                                                          |             
      Acinus, Parotid Gland, Necrosis,     |                                                                          |             
           Focal                           |                               1     1                                    |             
      Acinus, Submandibular Gland, Atrophy |                                                                          |             
      Parotid Gland, Infiltration Cellular,|                                                                          |             
           Lymphocytic                     |          1     1        1                                   2            |             
      Sublingual Gland, Infiltration       |                                                                          |             
          Cellular, Lymphocytic            |                                                                          |             
      Submandibular Gland, Infiltration    |                                                                          |             
          Cellular, Lymphocytic            |          1  2  3        1  2  1        1  2  1  1  1  2     2  2  1  1   |             
                                           |__________________________________________________________________________|             
   Stomach                                 | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                               2     2  2              1                  |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                     1                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    408 PPM                                | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Mineralization                       | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Accessory Adrenal Cortical   |                                                                          |             
          Nodule                           |                                                                X         |             
      Cortex, Hematopoietic Cell           |                                                                          |             
          Proliferation                    | 3                                                                        |             
      Cortex, Subcapsular, Hyperplasia     | 2     2  1  2  2  1  2  2  2  2  2  2  2  1  2  2  2  1  1  3  1  2  2  2|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | A     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                           2                              |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Thymus                       |                                     X                                    |             
      Follicular Cell, Cyst                |                   2              1                                2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Duct, Cyst                           |       2  1  2  2  2  2  2  2  2  2  2  2  1  2  2  2  1  2  2  1     2  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | M     I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2  2  2  3  2  2  2  2  2  2     2  2     2  2  3  2  2  3  2|             
      Cyst                                 |                                     X     X              X        X      |             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    408 PPM                                | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Bilateral, Cyst                      |                         X     X                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1                                                            |             
      Hyperplasia, Cystic                  |       2     4  2  1  1  2  3  2  3  2  2  3  2  1  4  2  3  1  3  2  4  2|             
      Inflammation, Acute                  |             3                                                            |             
                                           |__________________________________________________________________________|             
   Vagina                                  | M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                 2              2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |          2  2  3  2                                         2            |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Hyperplasia, Plasma Cell     |             3                                                            |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                           3  3                    2      |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                  4                                       |             
      Thoracic, Hyperplasia, Plasma Cell   |             3                                                            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | A     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          3  3  4  3           1  3  2              1  1     2     3      |             
      Hyperplasia, Lymphoid                |                                           2  2        3                  |             
      Infiltration Cellular, Plasma Cell   |                                  4                                       |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +     M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        X                                 |             
      Ectopic Parathyroid Gland            |             X                    X           X                           |             
      Hyperplasia, Lymphoid                |                                              2     2                 2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    408 PPM                                | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | A     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocytic   |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | A     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
      Sternum, Degeneration, Cystic        |                   1           1              1                           |             
      Sternum, Fibrous Osteodystrophy      |                                  2  1  1  1        1     1     1        2|             
                                           |__________________________________________________________________________|             
   Bone, Femur                             | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Infiltration Cellular,   |                                                                          |             
           Lymphocytic                     |                                                       2                  |             
      Cerebrum, Mineralization             | 1              1              1        1                 1  1  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thoracic, Infiltration Cellular,     |                                                                          |             
           Lymphocytic                     |                                                       1                  |             
      Thoracic, Axon, Degeneration         |                      1                 1     1           1  1           1|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    408 PPM                                | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Spinal Cord, Thoracic                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Crystals                             |             3                                                            |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Histiocytic   |                                                       1           1      |             
      Infiltration Cellular, Lymphocytic   |             2  3           1     2                 1  1     1  2         |             
      Inflammation, Chronic, Focal         |                            1                                             |             
      Inflammation, Granulomatous          |             2                                                            |             
      Leukocytosis                         |          4                                                               |             
      Alveolar Epithelium, Hyperplasia     |                                              1                           |             
      Artery, Mineralization               |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Phthisis Bulbi                       |                                                                          |             
      Bilateral, Lens, Cataract            | 3     4  3           3                       2                 1  1      |             
      Conjunctiva, Polyarteritis           |                                                                          |             
      Lens, Cataract                       |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1        2                          2                              |             
      Infiltration Cellular, Lymphocytic   |                            1                       1        1            |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                                                             1            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    408 PPM                                | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|             
                                           | 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocytic   |                               1  1     1     1        2        1         |             
      Nephropathy                          |                                                 1                        |             
      Glomerulus, Casts Protein            |                3                                                         |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          | 3              2                                                         |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | A     A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inclusion Body Intracytoplasmic      |          2  2  2  3     3  3  2  3  3  3  3  3  3  3  3  3  3  3  3  3  3|             
      Infiltration Cellular, Lymphocytic   |                1  1        1           2  1     1     3  1  1        1  1|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    408 PPM                                | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mucosa, Hyperplasia, Focal           |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Colon, Proliferation Connective      |                                                                          |            |
          Tissue                           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Ileum, Hyperplasia, Lymphoid         |                               4                                          |      1  4.0|
      Jejunum, Hyperplasia, Lymphoid       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Basophilic Focus                     |                                           X                              |      2     |
      Basophilic Focus, Two                |                                                                          |      1     |
      Eosinophilic Focus, Single           |                                           X                              |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.0|
      Infiltration Cellular, Lymphocytic   |                      1           1     2        1                        |      8  1.3|
      Inflammation, Chronic Active, Focal  |          1  2           1           1     2                              |     11  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    408 PPM                                | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Leukocytosis                         |                                                                          |      1  2.0|
      Tension Lipidosis                    | 1     1                    2        1  2                    1            |      9  1.2|
      Bile Duct, Cyst                      |                                                                2         |      1  2.0|
      Serosa, Fibrosis                     |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                      +  +                                                |   3        |
      Fat, Necrosis, Focal                 |                      2  2                                                |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Cytoplasmic Alteration               |                                           2        1                     |      2  1.5|
      Infiltration Cellular, Lymphocytic   |       1     1                          1              1                  |      6  1.2|
      Acinus, Atrophy                      |    4                                                                     |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Acinus, Parotid Gland, Atrophy       |    3                                                                     |      1  3.0|
      Acinus, Parotid Gland, Necrosis,     |                                                                          |            |
           Focal                           |                                                                          |      2  1.0|
      Acinus, Submandibular Gland, Atrophy |    3                                                                     |      1  3.0|
      Parotid Gland, Infiltration Cellular,|                                                                          |            |
           Lymphocytic                     |             2                    1     1  1           2  1  2            |     11  1.4|
      Sublingual Gland, Infiltration       |                                                                          |            |
          Cellular, Lymphocytic            |             1                                                            |      1  1.0|
      Submandibular Gland, Infiltration    |                                                                          |            |
          Cellular, Lymphocytic            | 1     2  1  2     2     1        1  1  3  1  1  1  1     2  1            |     31  1.5|
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Forestomach, Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                               1  1                                       |      6  1.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    408 PPM                                | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Foreign Body                         |          1                                         1        1            |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Inflammation, Acute, Focal           |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cortex, Accessory Adrenal Cortical   |                                                                          |            |
          Nodule                           |                                                                          |      1     |
      Cortex, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Cortex, Subcapsular, Hyperplasia     | 2  1  2  2  2  2  2  2  2  1  2  2  2  3  1  2  2  2  2  2  2  2  2      |     47  1.9|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Pars Distalis, Hyperplasia, Focal    |                                        3                                 |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Ectopic Thymus                       |                                                                          |      1     |
      Follicular Cell, Cyst                |    1                             1        1        1           1  2      |      9  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    408 PPM                                | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Duct, Cyst                           | 2  1  2  2  2  2  2  2  1  1  2  2  1  2  1  2  2  2  2  2  2  2  2      |     45  1.8|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
      Atrophy                              | 2     2  2  3  2  2  2  3  2  2  1  2  2  2  1  1  2  2  2  2  2  2      |     41  2.0|
      Cyst                                 |    X        X     X              X     X                 X               |     10     |
      Hemorrhage                           |                1     1                                                   |      2  1.0|
      Bilateral, Cyst                      |                               X                                          |      3     |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hyperplasia, Cystic                  | 2     2  3  4  3  3  3  3  3  2  3  2  2     3  4  2  2  2  3  3  3      |     43  2.5|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Epithelium, Hyperplasia              |    1                                                                     |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Myeloid Cell, Hyperplasia            |                               2                                          |      6  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                   2                    2                                 |      2  2.0|
      Mesenteric, Hemorrhage               |                                           1                              |      1  1.0|
      Mesenteric, Hyperplasia, Lymphoid    |                               3        3                    2            |      6  2.7|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  4.0|
      Thoracic, Hyperplasia, Plasma Cell   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    408 PPM                                | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Hematopoietic Cell Proliferation     |                                        2  3  3     1     1        2      |     17  2.2|
      Hyperplasia, Lymphoid                |       1              2        3        3        2        1               |      9  2.1|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Cyst                                 |                                                             X            |      2     |
      Ectopic Parathyroid Gland            |                         X                    X  X  X                     |      7     |
      Hyperplasia, Lymphoid                |             1                          3        1                        |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Infiltration Cellular, Lymphocytic   |                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Femur, Fibrous Osteodystrophy        |                         1           1        1                           |      3  1.0|
      Sternum, Degeneration, Cystic        |                1                                            1            |      5  1.0|
      Sternum, Fibrous Osteodystrophy      | 1     1  2  1  1              2  1           2  1     1  1  1  1         |     21  1.2|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Mineralization                       |    2                                                                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    408 PPM                                | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
      Cerebellum, Infiltration Cellular,   |                                                                          |            |
           Lymphocytic                     |                                                                          |      1  2.0|
      Cerebrum, Mineralization             |             1  1  1              1  1     1  1  1        1  1  1         |     21  1.0|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Thoracic, Infiltration Cellular,     |                                                                          |            |
           Lymphocytic                     |                                                                          |      1  1.0|
      Thoracic, Axon, Degeneration         |       2  1     1  1     1        1     3                          1      |     14  1.2|
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Crystals                             |                                                                          |      1  3.0|
      Infarct                              |                                                          2               |      1  2.0|
      Infiltration Cellular, Histiocytic   |                                                                          |      2  1.0|
      Infiltration Cellular, Lymphocytic   |             1     1     2                                   1            |     12  1.5|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Leukocytosis                         |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Artery, Mineralization               |                                                 1                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03    
Route: DOSED FEED                                                                                                 Time: 07:07:49    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   C57BL/6N XC3H/HEN MTN-NCTR FEMALE       | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    408 PPM                                | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Phthisis Bulbi                       |                   X                                                      |      1     |
      Bilateral, Lens, Cataract            |                                                                          |      7  2.4|
      Conjunctiva, Polyarteritis           |                                        2                                 |      1  2.0|
      Lens, Cataract                       | 2                                                  2        2            |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                                                                          |      3  1.7|
      Infiltration Cellular, Lymphocytic   |                                                    1        1            |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Glomerulosclerosis                   |                                                                          |      1  1.0|
      Infarct                              |                                                    1                     |      1  1.0|
      Infiltration Cellular, Lymphocytic   |             1        2        1        2                       1         |     11  1.3|
      Nephropathy                          |                                                                          |      1  1.0|
      Glomerulus, Casts Protein            |                                                                          |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |    2                                                                     |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
      Inclusion Body Intracytoplasmic      | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3      |     44  2.9|
      Infiltration Cellular, Lymphocytic   | 1  1  1     2     2  1     2     1     1  2  1     1     1  1  1         |     26  1.3|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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