https://ntp.niehs.nih.gov/go/3960

TDMS Study 93029-04 Pathology Tables

NTP Experiment-Test: 93029-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/19/03
Route: DOSED FEED                                            LEUKOMALACHITE GREEN                                 Time: 07:13:27
       Facility:  National Center for Toxicological Research
       Chemical CAS #:  129-73-7
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
                                                              Page   1
NTP Experiment-Test: 93029-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/19/03    
Route: DOSED FEED                                            LEUKOMALACHITE GREEN                                 Time: 07:13:27    
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE            0 PPM        91 PPM       204 PPM      408 PPM                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          48           48           48           48                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            2            2            5                                     
    Moribund                                           4            5            7            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           41           39           39                                     
  Animals Examined Microscopically                    47           48           47           47                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Gallbladder                                        (44)         (47)         (44)         (46)                                   
      Infiltration Cellular, Lymphocytic                            1 [2.0]                                                         
      Inflammation, Acute                                                                     1 [2.0]                               
      Polyarteritis                                    1 [1.0]                                                                      
      Mucosa, Hyperplasia, Focal                                                              2 [1.0]                               
   Intestine Large                                    (46)         (48)         (47)         (46)                                   
      Cecum, Polyarteritis                                                       1 [2.0]                                            
      Colon, Angiectasis                                                         1 [2.0]                                            
      Colon, Proliferation Connective Tissue                                                  1 [2.0]                               
      Rectum, Inflammation, Chronic                    1 [3.0]      1 [2.0]                                                         
      Rectum, Polyarteritis                                                      1 [2.0]                                            
   Intestine Small                                    (44)         (47)         (47)         (46)                                   
      Ileum, Hyperplasia, Lymphoid                     1 [2.0]      1 [1.0]      3 [1.7]      1 [4.0]                               
      Jejunum, Hyperplasia, Lymphoid                                             2 [2.0]      1 [2.0]                               
   Liver                                              (47)         (48)         (47)         (47)                                   
      Basophilic Focus                                 1            2                         2                                     
      Basophilic Focus, Two                                                                   1                                     
      Clear Cell Focus                                              1            1                                                  
      Eosinophilic Focus, Single                                                 1            1                                     
      Hematopoietic Cell Proliferation                 2 [1.5]      2 [3.0]      3 [2.3]      3 [2.0]                               
      Infarct                                                                    1 [4.0]                                            
      Infiltration Cellular, Lymphocytic               8 [1.5]      2 [1.5]      2 [2.0]      8 [1.3]                               
      Inflammation, Chronic Active, Focal             15 [1.4]     13 [1.3]     16 [1.1]     11 [1.3]                               
      Leukocytosis                                                                            1 [2.0]                               
      Mineralization, Focal                            1 [1.0]                                                                      
      Necrosis                                         1 [2.0]                                                                      
      Tension Lipidosis                               10 [1.6]     12 [1.1]      9 [1.3]      9 [1.2]                               
      Vacuolization Cytoplasmic                        2 [2.0]      1 [1.0]                                                         
      Bile Duct, Cyst                                  3 [2.3]      1 [2.0]      1 [2.0]      1 [2.0]                               
      Oval Cell, Hyperplasia                           1 [2.0]                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    2                                                              
NTP Experiment-Test: 93029-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/19/03    
Route: DOSED FEED                                            LEUKOMALACHITE GREEN                                 Time: 07:13:27    
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE            0 PPM        91 PPM       204 PPM      408 PPM                                
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT                                                                                                            
      Serosa, Fibrosis                                                                        1 [2.0]                               
   Mesentery                                          (1)          (2)          (1)          (3)                                    
      Fat, Necrosis, Focal                             1 [2.0]      2 [2.0]      1 [1.0]      3 [2.0]                               
   Pancreas                                           (45)         (48)         (47)         (45)                                   
      Cyst                                                          2 [2.0]                                                         
      Cytoplasmic Alteration                           1 [1.0]      1 [1.0]      1 [1.0]      2 [1.5]                               
      Infiltration Cellular, Lymphocytic               7 [1.4]      9 [1.1]      4 [1.0]      6 [1.2]                               
      Polyarteritis                                                              1 [3.0]                                            
      Acinus, Atrophy                                  1 [1.0]      2 [2.0]      1 [1.0]      2 [3.0]                               
   Salivary Glands                                    (47)         (48)         (47)         (47)                                   
      Acinus, Parotid Gland, Atrophy                   1 [1.0]      3 [2.7]                   1 [3.0]                               
      Acinus, Parotid Gland, Necrosis, Focal                                     3 [1.3]      2 [1.0]                               
      Acinus, Submandibular Gland, Atrophy             1 [2.0]      1 [3.0]                   1 [3.0]                               
      Parotid Gland, Infiltration Cellular,                                                                                         
        Lymphocytic                                    9 [1.2]      9 [1.1]      8 [1.5]     11 [1.4]                               
      Parotid Gland, Vacuolization Cytoplasmic         2 [2.0]                   1 [2.0]                                            
      Sublingual Gland, Infiltration Cellular,                                                                                      
         Lymphocytic                                                             2 [1.0]      1 [1.0]                               
      Submandibular Gland, Infiltration Cellular,                                                                                   
         Lymphocytic                                  33 [1.6]     30 [1.5]     35 [1.6]     31 [1.5]                               
   Stomach                                            (46)         (48)         (47)         (46)                                   
      Forestomach, Foreign Body                                                  1 [2.0]                                            
      Forestomach, Hyperkeratosis, Focal               1 [1.0]                                                                      
      Forestomach, Infiltration Cellular,                                                                                           
        Lymphocytic                                    1 [2.0]                                                                      
      Forestomach, Inflammation, Chronic Active                                  2 [2.0]                                            
      Forestomach, Epithelium, Hyperplasia, Diffuse    1 [3.0]                                                                      
      Forestomach, Epithelium, Hyperplasia, Focal      3 [2.0]      4 [1.5]      8 [2.3]      6 [1.5]                               
      Glandular, Infiltration Cellular, Lymphocytic    1 [2.0]      2 [2.0]      1 [1.0]                                            
      Glandular, Polyarteritis                                                   1 [2.0]                                            
      Glandular, Ulcer                                 1 [2.0]                                                                      
   Tongue                                             (47)         (48)         (47)         (47)                                   
      Foreign Body                                                  3 [1.0]      1 [1.0]      3 [1.0]                               
      Artery, Inflammation, Chronic                    1 [2.0]      2 [2.0]      2 [2.0]                                            
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Blood Vessel                                       (47)         (48)         (46)         (46)                                   
      Aorta, Embolus Bacterial                                      1 [4.0]                                                         
   Heart                                              (47)         (48)         (47)         (47)                                   
      Cardiomyopathy                                                1 [1.0]                                                         
      Inflammation, Acute, Focal                                    1 [2.0]                   1 [1.0]                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    3                                                              
NTP Experiment-Test: 93029-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/19/03    
Route: DOSED FEED                                            LEUKOMALACHITE GREEN                                 Time: 07:13:27    
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE            0 PPM        91 PPM       204 PPM      408 PPM                                
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Mineralization                                                                          1 [1.0]                               
      Polyarteritis                                    1 [3.0]                                                                      
      Atrium Left, Thrombosis                          1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Gland                                      (46)         (48)         (47)         (47)                                   
      Bilateral, Cortex, Hypertrophy, Focal                                      1 [2.0]                                            
      Cortex, Accessory Adrenal Cortical Nodule        3            1            1            1                                     
      Cortex, Cyst                                     1                                                                            
      Cortex, Hematopoietic Cell Proliferation                                   1 [1.0]      1 [3.0]                               
      Cortex, Hyperplasia, Focal                       2 [1.0]                   2 [2.0]                                            
      Cortex, Hypertrophy, Focal                       2 [1.5]      2 [2.0]      1 [3.0]                                            
      Cortex, Polyarteritis                                                      1 [3.0]                                            
      Cortex, Subcapsular, Hyperplasia                42 [1.9]     47 [1.9]     46 [1.8]     47 [1.9]                               
      Medulla, Hyperplasia, Focal                                   1 [1.0]                                                         
   Parathyroid Gland                                  (42)         (42)         (41)         (44)                                   
      Infiltration Cellular, Lymphocytic                            1 [3.0]                                                         
   Pituitary Gland                                    (41)         (45)         (44)         (46)                                   
      Pars Distalis, Hyperplasia, Focal                3 [1.3]      1 [1.0]      3 [1.3]      2 [2.5]                               
   Thyroid Gland                                      (46)         (48)         (47)         (47)                                   
      Ectopic Thymus                                                                          1                                     
      Polyarteritis                                                              1 [3.0]                                            
      Ultimobranchial Cyst                                          2            2                                                  
      Follicular Cell, Cyst                            7 [1.7]     10 [1.5]      6 [1.0]      9 [1.3]                               
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (45)         (46)         (44)         (45)                                   
      Inflammation, Chronic                                         1 [2.0]                                                         
      Inflammation, Subacute                                                     1 [2.0]                                            
      Duct, Cyst                                      44 [1.9]     46 [1.9]     41 [1.9]     45 [1.8]                               
   Ovary                                              (46)         (48)         (47)         (44)                                   
      Abscess                                                       1                                                               
      Angiectasis                                      1 [2.0]      1 [2.0]      2 [2.0]                                            
      Atrophy                                         42 [1.9]     45 [1.7]     44 [1.9]     41 [2.0]                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    4                                                              
NTP Experiment-Test: 93029-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/19/03    
Route: DOSED FEED                                            LEUKOMALACHITE GREEN                                 Time: 07:13:27    
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE            0 PPM        91 PPM       204 PPM      408 PPM                                
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                            14           16           17           10                                     
      Hemorrhage                                       4 [1.8]      2 [2.0]      2 [1.0]      2 [1.0]                               
      Mineralization                                                             1 [1.0]                                            
      Thrombosis                                       3 [3.0]                                                                      
      Bilateral, Cyst                                  7            3            2            3                                     
   Uterus                                             (46)         (48)         (47)         (46)                                   
      Adenomyosis, Focal                               1 [3.0]                                                                      
      Angiectasis                                                   4 [1.8]      3 [1.3]      1 [1.0]                               
      Hyperplasia, Cystic                             42 [2.4]     46 [2.6]     47 [2.4]     43 [2.5]                               
      Inflammation, Acute                                                                     1 [3.0]                               
      Polyarteritis                                                              1 [2.0]                                            
      Thrombosis                                                    1 [4.0]      3 [2.3]                                            
      Endometrium, Metaplasia                                       1 [2.0]                                                         
      Stroma, Fibrosis                                                           1 [3.0]                                            
      Stroma, Hyperplasia                                                        1 [3.0]                                            
   Vagina                                             (45)         (47)         (47)         (46)                                   
      Epithelium, Hyperplasia                          1 [2.0]                                3 [1.7]                               
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (46)         (48)         (47)         (46)                                   
      Angiectasis, Focal                               1 [2.0]                                                                      
      Fibrosis                                                      1 [3.0]      1 [3.0]                                            
      Femoral, Infarct                                 1 [2.0]                                                                      
      Myeloid Cell, Hyperplasia                        4 [2.3]      1 [2.0]      4 [3.0]      6 [2.2]                               
   Lymph Node                                         (47)         (48)         (47)         (47)                                   
      Inguinal, Hyperplasia, Lymphoid                               1 [1.0]                                                         
      Lumbar, Cyst                                     1                                                                            
      Lumbar, Hematopoietic Cell Proliferation         1 [3.0]                                                                      
      Lumbar, Hyperplasia, Lymphoid                    1 [3.0]                                                                      
      Lumbar, Hyperplasia, Plasma Cell                                                        1 [3.0]                               
      Mandibular, Hyperplasia, Lymphoid                1 [2.0]      3 [2.7]      8 [2.6]      2 [2.0]                               
      Mediastinal, Hyperplasia, Lymphoid               1 [2.0]                                                                      
      Mesenteric, Hematopoietic Cell Proliferation     1 [2.0]                   1 [2.0]                                            
      Mesenteric, Hemorrhage                           1 [1.0]      1 [2.0]      1 [2.0]      1 [1.0]                               
      Mesenteric, Hyperplasia, Lymphoid                5 [2.2]      2 [2.0]      3 [2.7]      6 [2.7]                               
      Mesenteric, Infiltration Cellular, Plasma                                                                                     
        Cell                                                                     2 [3.0]      1 [4.0]                               
      Renal, Hyperplasia, Lymphoid                     2 [2.5]                                                                      
      Thoracic, Hyperplasia, Plasma Cell                                                      1 [3.0]                               
   Spleen                                             (45)         (48)         (47)         (45)                                   
      Angiectasis                                                   1 [2.0]                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    5                                                              
NTP Experiment-Test: 93029-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/19/03    
Route: DOSED FEED                                            LEUKOMALACHITE GREEN                                 Time: 07:13:27    
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE            0 PPM        91 PPM       204 PPM      408 PPM                                
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                11 [2.5]      9 [2.6]     17 [2.1]     17 [2.2]                               
      Hyperplasia, Lymphoid                           14 [2.1]      4 [1.8]      8 [2.1]      9 [2.1]                               
      Infiltration Cellular, Plasma Cell                            1 [4.0]                   1 [4.0]                               
      Proliferation Connective Tissue, Focal           1 [1.0]                                                                      
   Thymus                                             (43)         (45)         (45)         (43)                                   
      Atrophy                                          2 [2.0]      2 [2.5]      1 [2.0]                                            
      Cyst                                             2            1            2            2                                     
      Ectopic Parathyroid Gland                        4            7            4            7                                     
      Hyperplasia, Lymphoid                            2 [1.5]      3 [1.3]      5 [2.0]      6 [1.8]                               
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (46)         (48)         (47)         (45)                                   
      Infiltration Cellular, Lymphocytic                                                      1 [2.0]                               
   Skin                                               (46)         (48)         (45)         (45)                                   
      Face, Ulcer                                      1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (47)         (48)         (47)         (47)                                   
      Femur, Fibrous Osteodystrophy                    8 [1.4]      2 [1.0]      5 [1.6]      3 [1.0]                               
      Sternum, Degeneration, Cystic                    1 [1.0]      3 [1.0]      1 [1.0]      5 [1.0]                               
      Sternum, Fibrous Osteodystrophy                 26 [1.4]     21 [1.4]     19 [1.4]     21 [1.2]                               
   Skeletal Muscle                                    (47)         (48)         (47)         (46)                                   
      Mineralization                                                                          2 [2.0]                               
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (47)         (48)         (47)         (47)                                   
      Cerebellum, Infiltration Cellular,                                                                                            
        Lymphocytic                                                                           1 [2.0]                               
      Cerebrum, Mineralization                        15 [1.0]     18 [1.0]     21 [1.0]     21 [1.0]                               
      Cerebrum, Polyarteritis                                                    1 [1.0]                                            
   Spinal Cord                                        (47)         (48)         (47)         (47)                                   
      Thoracic, Infiltration Cellular, Lymphocytic                                            1 [1.0]                               
      Thoracic, Axon, Degeneration                    12 [1.0]     11 [1.2]      9 [1.0]     14 [1.2]                               
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    6                                                              
NTP Experiment-Test: 93029-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/19/03    
Route: DOSED FEED                                            LEUKOMALACHITE GREEN                                 Time: 07:13:27    
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE            0 PPM        91 PPM       204 PPM      408 PPM                                
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT                                                                                                           
   Lung                                               (47)         (48)         (47)         (47)                                   
      Crystals                                                      1 [2.0]                   1 [3.0]                               
      Hemorrhage, Focal                                1 [2.0]                                                                      
      Infarct                                                                                 1 [2.0]                               
      Infiltration Cellular, Histiocytic               1 [1.0]      2 [1.0]                   2 [1.0]                               
      Infiltration Cellular, Lymphocytic              13 [1.8]      7 [1.7]      9 [1.8]     12 [1.5]                               
      Inflammation, Chronic, Focal                     1 [1.0]      1 [1.0]                   1 [1.0]                               
      Inflammation, Granulomatous                                                             1 [2.0]                               
      Leukocytosis                                                  2 [2.0]                   1 [4.0]                               
      Alveolar Epithelium, Hyperplasia                 1 [1.0]      1 [1.0]      1 [1.0]      1 [1.0]                               
      Artery, Mineralization                                                                  1 [1.0]                               
      Vein, Thrombosis                                 1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Eye                                                (47)         (48)         (47)         (47)                                   
      Phthisis Bulbi                                                                          1                                     
      Bilateral, Lens, Cataract                        4 [3.3]      5 [2.0]      3 [2.3]      7 [2.4]                               
      Conjunctiva, Polyarteritis                                                              1 [2.0]                               
      Cornea, Inflammation, Chronic                    1 [2.0]                                                                      
      Lens, Cataract                                   5 [1.8]      4 [1.8]      4 [2.0]      4 [1.8]                               
   Harderian Gland                                    (47)         (48)         (47)         (47)                                   
      Atrophy                                                       1 [1.0]                                                         
      Hyperplasia                                                   1 [2.0]      1 [2.0]      3 [1.7]                               
      Infiltration Cellular, Lymphocytic               4 [1.3]      9 [1.6]      8 [1.1]      5 [1.0]                               
      Acinus, Dilatation                                            1 [2.0]                                                         
   Zymbal's Gland                                     (47)         (47)         (46)         (47)                                   
      Atrophy                                                       1 [2.0]                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (47)         (48)         (47)         (47)                                   
      Glomerulosclerosis                               1 [1.0]                                1 [1.0]                               
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
      Infarct                                          2 [1.0]                   1 [1.0]      1 [1.0]                               
      Infiltration Cellular, Lymphocytic               9 [1.4]      5 [1.0]     15 [1.1]     11 [1.3]                               
      Nephropathy                                      1 [3.0]      2 [1.0]      3 [1.0]      1 [1.0]                               
      Polyarteritis                                                              1 [3.0]                                            
      Glomerulus, Casts Protein                                     1 [2.0]                   1 [3.0]                               
      Papilla, Casts Protein                           1 [1.0]                                                                      
      Pelvis, Dilatation                               2 [3.5]      1 [3.0]                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    7                                                              
NTP Experiment-Test: 93029-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/19/03    
Route: DOSED FEED                                            LEUKOMALACHITE GREEN                                 Time: 07:13:27    
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE            0 PPM        91 PPM       204 PPM      408 PPM                                
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Accumulation, Hyaline Droplet      1 [3.0]      2 [2.5]      1 [2.0]      3 [2.3]                               
      Renal Tubule, Hyperplasia                                     1 [2.0]                                                         
      Renal Tubule, Hypertrophy                                     1 [1.0]                                                         
      Renal Tubule, Necrosis                                                     1 [2.0]                                            
      Renal Tubule, Pigmentation                                                 1 [2.0]                                            
   Urinary Bladder                                    (46)         (48)         (47)         (44)                                   
      Inclusion Body Intracytoplasmic                 14 [1.0]     33 [1.2]     44 [1.9]     44 [2.9]                               
      Infiltration Cellular, Lymphocytic              29 [1.4]     22 [1.1]     24 [1.2]     26 [1.3]                               
      Polyarteritis                                                              1 [1.0]                                            
      Submucosa, Edema                                                           1 [3.0]                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    8                                                              
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