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TDMS Study 96001-05 Pathology Tables

NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32

                                                           FINAL/RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  64742-88-7

       Lock Date:  09/24/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12           19           15           23                                     
    Natural Death                                      2            1            3            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           30           32           25                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (49)         (49)         (47)         (48)                                   
      Leiomyoma                                                                  1 (2%)                                             
   Liver                                              (49)         (50)         (50)         (50)                                   
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Carcinoma                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                          2 (4%)       4 (8%)       2 (4%)       2 (4%)                                
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          27 (55%)     34 (68%)     33 (66%)     28 (56%)                               
      Pars Distalis, Carcinoma                                      1 (2%)                    1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  3 (6%)       5 (10%)      2 (4%)       4 (8%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Carcinoma                                1 (2%)       2 (4%)                    1 (2%)                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                                       3 (6%)       5 (10%)      6 (12%)                               
      Carcinoma                                        1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
   Uterus                                             (49)         (50)         (50)         (50)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                   10 (20%)      9 (18%)     10 (20%)      9 (18%)                               
      Sarcoma Stromal                                               1 (2%)                    1 (2%)                                
      Cervix, Sarcoma Stromal                          1 (2%)                                                                       
   Vagina                                                                       (1)                                                 
      Sarcoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (5)          (5)          (5)          (4)                                    
   Lymph Node, Bronchial                              (12)         (7)          (8)          (11)                                   
   Lymph Node, Mandibular                             (3)                       (2)                                                 
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
   Lymph Node, Mediastinal                            (45)         (39)         (42)         (45)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Thymus                                             (47)         (47)         (46)         (48)                                   
      Thymoma Malignant                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                        3 (6%)       2 (4%)       9 (18%)      7 (14%)                               
      Carcinoma, Multiple                              1 (2%)                    1 (2%)       1 (2%)                                
      Fibroadenoma                                    14 (28%)     13 (26%)     10 (20%)     16 (32%)                               
      Fibroadenoma, Multiple                           5 (10%)     13 (26%)     12 (24%)      8 (16%)                               
      Fibroma                                                                    1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Keratoacanthoma                                  1 (2%)                                                                       
      Sarcoma                                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                                            2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          2 (4%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Benign           1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
      Glioma Malignant                                                                        1 (2%)                                
      Cerebellum, Glioma Malignant                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                                            1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                    2 (4%)       1 (2%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
   Pleura                                             (48)         (50)         (50)         (50)                                   
      Mesothelium, Carcinoma, Metastatic, Lung                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            26 (52%)     28 (56%)     26 (52%)     29 (58%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44          50          50          48                                       
     Total Primary Neoplasms                          102         118         127         123                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37          47          42          43                                       
     Total Benign Neoplasms                            65          81          79          78                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          30          36          37                                       
     Total Malignant Neoplasms                         37          37          48          45                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           4           2                                       
     Total Metastatic Neoplasm                          2           1           4           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           27           21           27                                     
    Natural Death                                      3            4            8            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           19           21           16                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (49)         (48)         (48)                                   
   Intestine Small, Ileum                             (49)         (48)         (46)         (46)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma                                                         1 (2%)                                             
      Hepatocellular Adenoma                                        1 (2%)                    1 (2%)                                
   Mesentery                                          (7)          (11)         (11)         (13)                                   
   Oral Mucosa                                                                               (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Atrium, Carcinoma, Metastatic, Kidney                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                 2 (4%)                                
      Pheochromocytoma Benign                          5 (10%)      8 (16%)     12 (24%)     13 (26%)                               
      Bilateral, Pheochromocytoma Benign                            1 (2%)       1 (2%)       4 (8%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          3 (6%)       2 (4%)       1 (2%)       3 (6%)                                
      Carcinoma                                        1 (2%)                    3 (6%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          38 (76%)     36 (72%)     35 (70%)     31 (62%)                               
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)       1 (2%)                                             
      C-Cell, Adenoma                                  7 (14%)      5 (10%)      5 (10%)      4 (8%)                                
      C-Cell, Carcinoma                                2 (4%)       3 (6%)       2 (4%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (14)         (41)         (41)         (32)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)       2 (4%)       1 (2%)                                
      Carcinoma                                                     1 (2%)       3 (6%)                                             
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           26 (52%)     22 (44%)     28 (56%)     30 (60%)                               
      Interstitial Cell, Adenoma                      15 (30%)     17 (34%)     10 (20%)     12 (24%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (7)          (16)         (11)         (17)                                   
   Lymph Node, Bronchial                              (15)         (12)         (16)         (13)                                   
      Carcinoma, Metastatic, Kidney                                              1 (6%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
   Lymph Node, Mediastinal                            (42)         (44)         (43)         (40)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (3%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
   Thymus                                             (49)         (49)         (47)         (50)                                   
      Thymoma Malignant                                1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)       2 (4%)                                             
      Fibroadenoma                                     3 (6%)       1 (2%)       2 (4%)       4 (8%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Carcinoma                                          1 (2%)       1 (2%)       3 (6%)                                
      Squamous Cell Papilloma                          1 (2%)       2 (4%)                    2 (4%)                                
      Sebaceous Gland, Adenoma                         3 (6%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)       4 (8%)       2 (4%)       2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
      Subcutaneous Tissue, Lipoma                      2 (4%)                                 1 (2%)                                
      Subcutaneous Tissue, Schwannoma Benign                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Cranium, Osteosarcoma                            1 (2%)                                                                       
      Femur, Osteosarcoma                              1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (1)          (1)          (1)                                    
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                            1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                    2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (2%)                                             
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
      Thymoma Malignant, Metastatic, Thymus                                                   1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Oral Mucosa                                                      1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Respiratory Epithelium, Adenoma                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Lipoma                                                        1 (2%)                                                          
      Liposarcoma                                                                             1 (2%)                                
      Cortex, Renal Tubule, Adenoma                                              1 (2%)                                             
      Pelvis, Transitional Epithelium, Carcinoma                                 1 (2%)                                             
      Renal Tubule, Carcinoma                          1 (2%)                                 1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            25 (50%)     29 (58%)     30 (60%)     30 (60%)                               
      Lymphoma Malignant                                            1 (2%)                                                          
      Mesothelioma Malignant                                        1 (2%)                    2 (4%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 96001-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:10:32  
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         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          50                                       
     Total Primary Neoplasms                          145         143         149         153                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          50          49          48                                       
     Total Benign Neoplasms                           107         104         104         109                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          33          35          35                                       
     Total Malignant Neoplasms                         38          39          45          44                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       2           4                                       
     Total Metastatic Neoplasm                          2                       4           5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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