National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3976

TDMS Study 96001-05 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 01/08/03       
EXPERIMENT: 96001 TEST: 05                                                                                     TIME: 12:16:03       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 64742-88-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             FINAL/RATS                                                             
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 01/08/03       
EXPERIMENT: 96001 TEST: 05                                                                                     TIME: 12:16:03       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 64742-88-7      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF               STODDARD SOLVENT (TYPE IIC)                                                                        
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Vacuolization Cytoplasmic                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
                                       Necrosis                                                                                     
Heart                                  Cardiomyopathy                                                                               
Heart: Atrium                          Thrombosis                                                                                   
Kidney                                 Cyst                                                                                         
                                       Nephropathy Chronic                                                                          
Kidney: Cortex, Renal Tubule           Casts Granular                                                                               
                                       Hyperplasia                                                                                  
Kidney: Papilla                        Mineralization                                                                               
Kidney: Pelvis, Transitional Epithelium                                                                                             
                                       Hyperplasia                                                                                  
Lung                                   Inflammation                                                                                 
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
Nose: Goblet Cell                      Hyperplasia                                                                                  
Nose: Olfactory Epithelium             Degeneration Hyaline                                                                         
Pituitary Gland: Pars Distalis         Hemorrhage                                                                                   
Pleura                                 Fibrosis                                                                                     
                                       Inflammation Chronic                                                                         
Spleen                                 Fibrosis                                                                                     
                                       Necrosis                                                                                     
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Vacuolization Cytoplasmic                                                                    
Kidney                                 Nephropathy Chronic                                                                          
Kidney: Papilla                        Mineralization                                                                               
Kidney: Pelvis, Transitional Epithelium                                                                                             
                                       Mineralization                                                                               
Larynx                                 Inflammation Chronic                                                                         
Liver                                  Clear Cell Focus                                                                             
Liver: Hepatocyte                      Regeneration                                                                                 
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
Nose: Olfactory Epithelium             Degeneration Hyaline                                                                         
Pleura                                 Fibrosis                                                                                     
                                       Inflammation Chronic                                                                         
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Uterus                                 Necrosis                                                                                     
===============================================================                                                                     
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.09      1/38.81      1/41.36      0/39.41     |1/45.31      1/44.39      0/44.80      2/41.33      | 
|POLY-3 PERCENT (g) |     2.2%         2.6%         2.4%         0.0%        |2.2%         2.3%         0.0%         4.8%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     717          625          726          ---         |495          575          ---          625          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.380N     P=0.692      P=0.696      P=0.608N    |P=0.342      P=0.760N     P=0.504N     P=0.469      | 
|POLY 3             |     P=0.324N     P=0.726      P=0.741      P=0.527N    |P=0.349      P=0.756      P=0.502N     P=0.468      | 
|POLY 1.5           |     P=0.315N     P=0.742      P=0.749      P=0.515N    |P=0.356      P=0.758      P=0.502N     P=0.480      | 
|POLY 6             |     P=0.339N     P=0.703      P=0.731      P=0.544N    |P=0.342      P=0.753      P=0.504N     P=0.452      | 
|LOGISTIC REGRESSION|     P=0.315N     P=0.757N     P=0.722      P=0.568N    |P=0.520      P=0.774N     P=0.390N     P=0.631      | 
|COCH-ARM / FISHERS |     P=0.304N     P=0.753N     P=0.753N     P=0.500N    |P=0.366      P=0.753N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.325N     (e)          (e)          (e)         |P=0.240      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  5/50 (10%)   14/50 (28%)  10/50 (20%) |9/50 (18%)   4/50 (8%)    15/50 (30%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |     15/47.06     5/38.76      14/43.46     10/40.97    |9/45.39      4/44.30      15/45.22     12/42.40     | 
|POLY-3 PERCENT (g) |     31.9%        12.9%        32.2%        24.4%       |19.8%        9.0%         33.2%        28.3%        | 
|TERMINAL (d)       |     7/29 (24%)   4/19 (21%)   7/21 (33%)   4/16 (25%)  |7/36 (19%)   3/30 (10%)   12/32 (38%)  7/25 (28%)   | 
|FIRST INCIDENCE    |     476          642          546          522         |582          606          683          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.253      P=0.114N     P=0.390      P=0.546     |P=0.021 *    P=0.182N     P=0.080      P=0.114      | 
|POLY 3             |     P=0.535N     P=0.033N*    P=0.576      P=0.294N    |P=0.061      P=0.123N     P=0.113      P=0.248      | 
|POLY 1.5           |     P=0.516N     P=0.020N*    P=0.562N     P=0.239N    |P=0.072      P=0.120N     P=0.115      P=0.273      | 
|POLY 6             |     P=0.513      P=0.063N     P=0.528      P=0.385N    |P=0.050      P=0.131N     P=0.109      P=0.215      | 
|LOGISTIC REGRESSION|     P=0.530      P=0.022N*    P=0.487N     P=0.189N    |P=0.062      P=0.120N     P=0.121      P=0.271      | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.011N*    P=0.500N     P=0.178N    |P=0.094      P=0.117N     P=0.121      P=0.312      | 
|ORDER RESTRICTED   |     P=0.283N     (e)          (e)          (e)         |P=0.044 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  14/50 (28%)  23/50 (46%)  15/50 (30%) |4/50 (8%)    2/50 (4%)    7/50 (14%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     12/46.14     14/41.83     23/43.82     15/42.29    |4/44.90      2/44.19      7/45.55      4/41.89      | 
|POLY-3 PERCENT (g) |     26.0%        33.5%        52.5%        35.5%       |8.9%         4.5%         15.4%        9.6%         | 
|TERMINAL (d)       |     7/29 (24%)   6/19 (32%)   10/21 (48%)  6/16 (38%)  |3/36 (8%)    0/30 (0%)    3/32 (9%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     621          537          541          432         |656          656          610          549          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.046 *    P=0.128      P=0.004 **   P=0.056     |P=0.283      P=0.392N     P=0.237      P=0.508      | 
|POLY 3             |     P=0.138      P=0.296      P=0.007 **   P=0.230     |P=0.366      P=0.344N     P=0.269      P=0.605      | 
|POLY 1.5           |     P=0.171      P=0.344      P=0.010 *    P=0.271     |P=0.384      P=0.341N     P=0.265      P=0.620      | 
|POLY 6             |     P=0.097      P=0.233      P=0.005 **   P=0.177     |P=0.343      P=0.351N     P=0.273      P=0.584      | 
|LOGISTIC REGRESSION|     P=0.181      P=0.412      P=0.008 **   P=0.297     |P=0.420      P=0.341N     P=0.262      P=0.630N     | 
|COCH-ARM / FISHERS |     P=0.218      P=0.410      P=0.018 *    P=0.326     |P=0.415      P=0.339N     P=0.262      P=0.643N     | 
|ORDER RESTRICTED   |     P=0.047 *    (e)          (e)          (e)         |P=0.285      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      0/41.34      2/39.69     |0/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         5.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          673         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035 *    (e)          (e)          P=0.161     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.040 *    (e)          (e)          P=0.210     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.041 *    (e)          (e)          P=0.222     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.039 *    (e)          (e)          P=0.194     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.039 *    (e)          (e)          P=0.213     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.021 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  15/50 (30%)  10/50 (20%)  9/50 (18%)  |9/49 (18%)   8/50 (16%)   3/50 (6%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     13/47.02     15/43.98     10/42.92     9/42.20     |9/45.08      8/44.95      3/45.29      6/41.61      | 
|POLY-3 PERCENT (g) |     27.7%        34.1%        23.3%        21.3%       |20.0%        17.8%        6.6%         14.4%        | 
|TERMINAL (d)       |     4/29 (14%)   2/19 (11%)   4/21 (19%)   2/16 (13%)  |6/36 (17%)   3/30 (10%)   2/32 (6%)    2/25 (8%)    | 
|FIRST INCIDENCE    |     576          403          529          529         |509          481          581          506          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.281N     P=0.142      P=0.536N     P=0.569N    |P=0.341N     P=0.586      P=0.090N     P=0.517N     | 
|POLY 3             |     P=0.154N     P=0.329      P=0.409N     P=0.328N    |P=0.203N     P=0.503N     P=0.057N     P=0.346N     | 
|POLY 1.5           |     P=0.129N     P=0.366      P=0.369N     P=0.285N    |P=0.190N     P=0.493N     P=0.057N     P=0.316N     | 
|POLY 6             |     P=0.199N     P=0.277      P=0.467N     P=0.396N    |P=0.221N     P=0.519N     P=0.059N     P=0.388N     | 
|LOGISTIC REGRESSION|     P=0.062N     P=0.427N     P=0.291N     P=0.132N    |P=0.166N     P=0.479N     P=0.057N     P=0.295N     | 
|COCH-ARM / FISHERS |     P=0.102N     P=0.412      P=0.318N     P=0.235N    |P=0.169N     P=0.482N     P=0.056N     P=0.274N     | 
|ORDER RESTRICTED   |     P=0.244N     (e)          (e)          (e)         |P=0.162N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    5/50 (10%)   3/50 (6%)   |4/49 (8%)    3/50 (6%)    6/50 (12%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/46.29      4/40.21      5/42.41      3/40.67     |4/45.06      3/44.31      6/46.45      1/40.96      | 
|POLY-3 PERCENT (g) |     8.6%         10.0%        11.8%        7.4%        |8.9%         6.8%         12.9%        2.4%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |1/36 (3%)    1/30 (3%)    2/32 (6%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     476          403          556          465         |495          606          433          647          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527N     P=0.478      P=0.400      P=0.624N    |P=0.290N     P=0.557N     P=0.354      P=0.262N     | 
|POLY 3             |     P=0.490N     P=0.564      P=0.445      P=0.570N    |P=0.246N     P=0.509N     P=0.389      P=0.209N     | 
|POLY 1.5           |     P=0.464N     P=0.599      P=0.467      P=0.540N    |P=0.224N     P=0.500N     P=0.386      P=0.194N     | 
|POLY 6             |     P=0.528N     P=0.511      P=0.421      P=0.613N    |P=0.276N     P=0.523N     P=0.390      P=0.230N     | 
|LOGISTIC REGRESSION|     P=0.328N     P=0.306N     P=0.639      P=0.224N    |P=0.134N     P=0.473N     P=0.400      P=0.136N     | 
|COCH-ARM / FISHERS |     P=0.433N     P=0.643N     P=0.500      P=0.500N    |P=0.193N     P=0.489N     P=0.383      P=0.175N     | 
|ORDER RESTRICTED   |     P=0.523N     (e)          (e)          (e)         |P=0.177N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/49 (4%)    3/50 (6%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/43.62      3/43.87      3/44.88      1/40.65      | 
|POLY-3 PERCENT (g) |                                                        |4.6%         6.8%         6.7%         2.5%         | 
|TERMINAL (d)       |                                                        |2/35 (6%)    3/30 (10%)   2/32 (6%)    1/25 (4%)    | 
|FIRST INCIDENCE    |                                                        |730 (T)      730 (T)      710          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.469N     P=0.429      P=0.460      P=0.617N     | 
|POLY 3             |                                                        |P=0.378N     P=0.503      P=0.513      P=0.525N     | 
|POLY 1.5           |                                                        |P=0.362N     P=0.506      P=0.511      P=0.512N     | 
|POLY 6             |                                                        |P=0.400N     P=0.496      P=0.514      P=0.543N     | 
|LOGISTIC REGRESSION|                                                        |P=0.440N     P=0.429      P=0.504      P=0.617N     | 
|COCH-ARM / FISHERS |                                                        |P=0.336N     P=0.510      P=0.510      P=0.492N     | 
|ORDER RESTRICTED   |                                                        |P=0.371N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Lens                                                                                                                        | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   1/50 (2%)    3/49 (6%)    2/50 (4%)   |3/49 (6%)    2/50 (4%)    1/50 (2%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     6/45.25      1/38.44      3/40.62      2/39.59     |3/44.22      2/43.87      1/44.80      4/40.56      | 
|POLY-3 PERCENT (g) |     13.3%        2.6%         7.4%         5.1%        |6.8%         4.6%         2.2%         9.9%         | 
|TERMINAL (d)       |     5/29 (17%)   1/19 (5%)    2/21 (10%)   1/16 (6%)   |3/36 (8%)    2/30 (7%)    1/32 (3%)    2/25 (8%)    | 
|FIRST INCIDENCE    |     674          729 (T)      712          683         |730 (T)      730 (T)      730 (T)      611          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.391N     P=0.160N     P=0.402N     P=0.348N    |P=0.250      P=0.583N     P=0.348N     P=0.347      | 
|POLY 3             |     P=0.222N     P=0.086N     P=0.297N     P=0.179N    |P=0.345      P=0.504N     P=0.300N     P=0.453      | 
|POLY 1.5           |     P=0.221N     P=0.072N     P=0.279N     P=0.158N    |P=0.353      P=0.498N     P=0.300N     P=0.471      | 
|POLY 6             |     P=0.225N     P=0.113N     P=0.321N     P=0.214N    |P=0.335      P=0.514N     P=0.302N     P=0.430      | 
|LOGISTIC REGRESSION|     P=0.312N     P=0.153N     P=0.341N     P=0.254N    |P=0.320      P=0.583N     P=0.348N     P=0.458      | 
|COCH-ARM / FISHERS |     P=0.224N     P=0.056N     P=0.254N     P=0.134N    |P=0.368      P=0.490N     P=0.301N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.106N     (e)          (e)          (e)         |P=0.237      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  4/50 (8%)    5/50 (10%)   9/50 (18%)  |1/49 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     13/45.98     4/39.15      5/42.71      9/41.38     |1/44.71      0/43.87      1/44.90      2/41.13      | 
|POLY-3 PERCENT (g) |     28.3%        10.2%        11.7%        21.8%       |2.2%         0.0%         2.2%         4.9%         | 
|TERMINAL (d)       |     10/29 (35%)  2/19 (11%)   1/21 (5%)    2/16 (13%)  |0/36 (0%)    0/30 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     576          605          509          581         |582          ---          705          589          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.410      P=0.105N     P=0.112N     P=0.524     |P=0.206      P=0.500N     P=0.754      P=0.445      | 
|POLY 3             |     P=0.420N     P=0.033N*    P=0.044N*    P=0.324N    |P=0.232      P=0.504N     P=0.760N     P=0.471      | 
|POLY 1.5           |     P=0.424N     P=0.023N*    P=0.039N*    P=0.284N    |P=0.240      P=0.500N     P=0.758N     P=0.486      | 
|POLY 6             |     P=0.417N     P=0.053N     P=0.052N     P=0.382N    |P=0.224      P=0.509N     P=0.759      P=0.451      | 
|LOGISTIC REGRESSION|     P=0.455N     P=0.040N*    P=0.034N*    P=0.289N    |P=0.298      P=0.478N     P=0.748N     P=0.584      | 
|COCH-ARM / FISHERS |     P=0.431N     P=0.016N*    P=0.033N*    P=0.235N    |P=0.251      P=0.495N     P=0.747N     P=0.508      | 
|ORDER RESTRICTED   |     P=0.066N     (e)          (e)          (e)         |P=0.199      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    5/50 (10%)  |2/49 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.04      0/38.44      1/41.55      5/40.13     |2/45.18      1/44.16      2/44.81      1/40.79      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.4%         12.5%       |4.4%         2.3%         4.5%         2.5%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          675          667         |495          652          726          694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.005 **   P=0.584N     P=0.715      P=0.039 *   |P=0.516N     P=0.505N     P=0.674      P=0.549N     | 
|POLY 3             |     P=0.007 **   P=0.531N     P=0.743      P=0.076     |P=0.473N     P=0.508N     P=0.691      P=0.536N     | 
|POLY 1.5           |     P=0.008 **   P=0.518N     P=0.750      P=0.087     |P=0.460N     P=0.501N     P=0.693N     P=0.518N     | 
|POLY 6             |     P=0.007 **   P=0.552N     P=0.734      P=0.064     |P=0.490N     P=0.517N     P=0.685      P=0.558N     | 
|LOGISTIC REGRESSION|     P=0.007 **   (e)          P=0.748      P=0.071     |P=0.384N     P=0.464N     P=0.675N     P=0.388N     | 
|COCH-ARM / FISHERS |     P=0.009 **   P=0.500N     P=0.753N     P=0.102     |P=0.438N     P=0.492N     P=0.684N     P=0.492N     | 
|ORDER RESTRICTED   |     P=0.005 **   (e)          (e)          (e)         |P=0.490N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/49 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      0/41.34      2/39.73     |0/44.22      2/43.87      0/44.80      1/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         5.0%        |0.0%         4.6%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    1/16 (6%)   |0/36 (0%)    2/30 (7%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          642         |---          730 (T)      ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029 *    (e)          (e)          P=0.160     |P=0.457      P=0.199      (e)          P=0.427      | 
|POLY 3             |     P=0.040 *    (e)          (e)          P=0.210     |P=0.508      P=0.235      (e)          P=0.483      | 
|POLY 1.5           |     P=0.041 *    (e)          (e)          P=0.222     |P=0.522      P=0.238      (e)          P=0.492      | 
|POLY 6             |     P=0.039 *    (e)          (e)          P=0.194     |P=0.489      P=0.230      (e)          P=0.472      | 
|LOGISTIC REGRESSION|     P=0.041 *    (e)          (e)          P=0.225     |(e)          P=0.199      (e)          P=0.427      | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |P=0.543      P=0.253      (e)          P=0.505      | 
|ORDER RESTRICTED   |     P=0.021 *    (e)          (e)          (e)         |P=0.309      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy Chronic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 49/50 (98%)  50/50 (100%) 50/50 (100%)|42/49 (86%)  44/50 (88%)  46/50 (92%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     50/50.00     49/49.19     50/50.00     50/50.00    |42/45.91     44/46.62     46/47.66     44/45.98     | 
|POLY-3 PERCENT (g) |     100.0%       99.6%        100.0%       100.0%      |91.5%        94.4%        96.5%        95.7%        | 
|TERMINAL (d)       |     29/29 (100%) 19/19 (100%) 21/21 (100%) 16/16 (100%)|34/36 (94%)  30/30 (100%) 32/32 (100%) 25/25 (100%) | 
|FIRST INCIDENCE    |     476          403          396          432         |582          537          563          506          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.024 *    P=0.010 *    (e)          (e)         |P=0.003 **   P=0.063      P=0.073      P=0.004 **   | 
|POLY 3             |     P=0.996      P=1.000N     (e)          (e)         |P=0.201      P=0.434      P=0.239      P=0.310      | 
|POLY 1.5           |     P=0.772      P=0.897N     (e)          (e)         |P=0.275      P=0.463      P=0.227      P=0.374      | 
|POLY 6             |     P=1.000      P=1.000N     (e)          (e)         |P=0.140      P=0.372      P=0.286      P=0.256      | 
|LOGISTIC REGRESSION|     P=0.470      P=0.986N     (e)          (e)         |P=0.031 *    P=0.350      P=0.196      P=0.072      | 
|COCH-ARM / FISHERS |     P=0.468      P=0.500N     (e)          (e)         |P=0.414      P=0.484      P=0.251      P=0.484      | 
|ORDER RESTRICTED   |     P=0.379      (e)          (e)          (e)         |P=0.163      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex                                                                                                                   | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.45      1/39.25      1/41.90      2/39.91     |1/44.71      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     4.4%         2.6%         2.4%         5.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    0/21 (0%)    1/16 (6%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     611          421          556          581         |582          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.447      P=0.569N     P=0.565N     P=0.549     |P=0.313N     P=0.500N     P=0.500N     P=0.514N     | 
|POLY 3             |     P=0.507      P=0.551N     P=0.528N     P=0.646     |P=0.288N     P=0.504N     P=0.500N     P=0.519N     | 
|POLY 1.5           |     P=0.516      P=0.528N     P=0.517N     P=0.667     |P=0.295N     P=0.500N     P=0.498N     P=0.510N     | 
|POLY 6             |     P=0.492      P=0.586N     P=0.543N     P=0.615     |P=0.278N     P=0.509N     P=0.502N     P=0.532N     | 
|LOGISTIC REGRESSION|     P=0.604      P=0.252N     P=0.382N     P=0.643N    |P=0.226N     P=0.478N     P=0.457N     P=0.403N     | 
|COCH-ARM / FISHERS |     P=0.527      P=0.500N     P=0.500N     P=0.691N    |P=0.303N     P=0.495N     P=0.495N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.508      (e)          (e)          (e)         |P=0.138N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex, Renal Tubule                                                                                                     | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   3/50 (6%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.27      5/41.19      3/43.31      2/40.74     |0/44.22      0/43.87      0/44.80      1/41.23      | 
|POLY-3 PERCENT (g) |     4.3%         12.1%        6.9%         4.9%        |0.0%         0.0%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     476          403          396          432         |---          ---          ---          549          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381N     P=0.174      P=0.471      P=0.669     |P=0.190      (e)          (e)          P=0.491      | 
|POLY 3             |     P=0.413N     P=0.171      P=0.470      P=0.647     |P=0.190      (e)          (e)          P=0.486      | 
|POLY 1.5           |     P=0.385N     P=0.191      P=0.483      P=0.668     |P=0.194      (e)          (e)          P=0.493      | 
|POLY 6             |     P=0.455N     P=0.145      P=0.454      P=0.616     |P=0.185      (e)          (e)          P=0.476      | 
|LOGISTIC REGRESSION|     P=0.102N     P=0.659N     P=0.348N     P=0.199N    |P=0.291      (e)          (e)          P=0.631      | 
|COCH-ARM / FISHERS |     P=0.351N     P=0.218      P=0.500      P=0.691N    |P=0.200      (e)          (e)          P=0.505      | 
|ORDER RESTRICTED   |     P=0.398      (e)          (e)          (e)         |P=0.108      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex, Renal Tubule                                                                                                     | 
|     Casts Granular                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    3/50 (6%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      1/38.94      1/41.34      3/40.66     |0/44.22      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         2.4%         7.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    1/21 (5%)    1/16 (6%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          579          729 (T)      522         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.039 *    P=0.487      P=0.436      P=0.087     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.050      P=0.471      P=0.483      P=0.101     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.054      P=0.484      P=0.490      P=0.109     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.045 *    P=0.452      P=0.474      P=0.090     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.075      P=0.660      P=0.436      P=0.236     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.059      P=0.500      P=0.500      P=0.121     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex, Renal Tubule                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    8/50 (16%)   23/50 (46%) |0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      1/38.45      8/41.34      23/41.68    |0/44.22      0/43.87      1/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         19.4%        55.2%       |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    8/21 (38%)   10/16 (63%) |0/36 (0%)    0/30 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          726          729 (T)      563         |---          ---          730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.419      P<0.001 **   P<0.001 **  |P=0.657      (e)          P=0.477      (e)          | 
|POLY 3             |     P<0.001 **   P=0.469      P=0.002 **   P<0.001 **  |P=0.652      (e)          P=0.503      (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.482      P=0.003 **   P<0.001 **  |P=0.671      (e)          P=0.503      (e)          | 
|POLY 6             |     P<0.001 **   P=0.448      P=0.002 **   P<0.001 **  |P=0.626      (e)          P=0.501      (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.404      P<0.001 **   P<0.001 **  |(e)          (e)          P=0.477      (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.003 **   P<0.001 **  |P=0.697      (e)          P=0.505      (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.384      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Medulla                                                                                                                  | 
|     Casts Granular                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    1/50 (2%)    3/50 (6%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      3/39.78      1/41.82      3/39.87     |0/44.22      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         7.5%         2.4%         7.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    2/16 (13%)  |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          472          589          593         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.152      P=0.096      P=0.478      P=0.056     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.179      P=0.098      P=0.485      P=0.098     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.196      P=0.107      P=0.491      P=0.107     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.156      P=0.085      P=0.478      P=0.086     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.266      P=0.259      P=0.622      P=0.111     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.220      P=0.121      P=0.500      P=0.121     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.059      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    8/50 (16%)   30/50 (60%)  39/50 (78%) |3/49 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.04      8/39.96      30/46.16     39/48.11    |3/44.22      1/43.87      1/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         20.0%        65.0%        81.1%       |6.8%         2.3%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    3/19 (16%)   13/21 (62%)  12/16 (75%) |3/36 (8%)    1/30 (3%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      621          509          432         |730 (T)      730 (T)      730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **  |P=0.108N     P=0.372N     P=0.348N     P=0.192N     | 
|POLY 3             |     P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **  |P=0.076N     P=0.308N     P=0.300N     P=0.134N     | 
|POLY 1.5           |     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P=0.074N     P=0.303N     P=0.300N     P=0.126N     | 
|POLY 6             |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P=0.079N     P=0.316N     P=0.302N     P=0.146N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.013 *    P<0.001 **   P<0.001 **  |P=0.108N     P=0.372N     P=0.348N     (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.015 *    P<0.001 **   P<0.001 **  |P=0.071N     P=0.301N     P=0.301N     P=0.117N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.046N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis, Transitional Epithelium                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    8/50 (16%)   5/50 (10%)  |4/49 (8%)    3/50 (6%)    7/50 (14%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/45.04      2/38.72      8/42.46      5/39.88     |4/44.22      3/43.92      7/45.45      3/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         5.2%         18.8%        12.5%       |9.1%         6.8%         15.4%        7.4%         | 
|TERMINAL (d)       |     0/29 (0%)    1/19 (5%)    3/21 (14%)   2/16 (13%)  |4/36 (11%)   2/30 (7%)    5/32 (16%)   3/25 (12%)   | 
|FIRST INCIDENCE    |     ---          652          618          684         |730 (T)      719          563          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   P=0.157      P=0.003 **   P=0.010 *   |P=0.428      P=0.591N     P=0.212      P=0.617      | 
|POLY 3             |     P=0.012 *    P=0.205      P=0.003 **   P=0.021 *   |P=0.551      P=0.504N     P=0.276      P=0.546N     | 
|POLY 1.5           |     P=0.015 *    P=0.219      P=0.003 **   P=0.025 *   |P=0.550N     P=0.497N     P=0.275      P=0.523N     | 
|POLY 6             |     P=0.008 **   P=0.186      P=0.002 **   P=0.017 *   |P=0.509      P=0.515N     P=0.277      P=0.577N     | 
|LOGISTIC REGRESSION|     P=0.016 *    P=0.207      P=0.004 **   P=0.017 *   |P=0.534      P=0.553N     P=0.268      P=0.617      | 
|COCH-ARM / FISHERS |     P=0.022 *    P=0.247      P=0.003 **   P=0.028 *   |P=0.507N     P=0.489N     P=0.274      P=0.489N     | 
|ORDER RESTRICTED   |     P=0.006 **   (e)          (e)          (e)         |P=0.454      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis, Transitional Epithelium                                                                                          | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |25/49 (51%)  23/50 (46%)  27/50 (54%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      0/41.34      0/39.41     |25/44.69     23/44.62     27/45.21     27/42.53     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |55.9%        51.6%        59.7%        63.5%        | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |23/36 (64%)  17/30 (57%)  22/32 (69%)  18/25 (72%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |634          656          695          611          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.015 *    P=0.425      P=0.212      P=0.027 *    | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.192      P=0.417N     P=0.439      P=0.302      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.239      P=0.400N     P=0.448      P=0.362      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.148      P=0.446N     P=0.425      P=0.240      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.066      P=0.504N     P=0.412      P=0.145      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.329      P=0.383N     P=0.462      P=0.462      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.274      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    3/50 (6%)   |2/49 (4%)    1/50 (2%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/45.11      2/38.97      2/41.77      3/39.99     |2/44.88      1/43.87      2/44.83      1/39.65      | 
|POLY-3 PERCENT (g) |     2.2%         5.1%         4.8%         7.5%        |4.5%         2.3%         4.5%         2.5%         | 
|TERMINAL (d)       |     0/29 (0%)    1/19 (5%)    0/21 (0%)    0/16 (0%)   |1/36 (3%)    1/30 (3%)    1/32 (3%)    1/24 (4%)    | 
|FIRST INCIDENCE    |     712          565          647          645         |509          730 (T)      722          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.183      P=0.384      P=0.440      P=0.190     |P=0.552N     P=0.545N     P=0.664      P=0.595N     | 
|POLY 3             |     P=0.212      P=0.449      P=0.473      P=0.263     |P=0.480N     P=0.508N     P=0.694      P=0.543N     | 
|POLY 1.5           |     P=0.226      P=0.472      P=0.484      P=0.281     |P=0.467N     P=0.501N     P=0.691N     P=0.526N     | 
|POLY 6             |     P=0.192      P=0.416      P=0.461      P=0.239     |P=0.497N     P=0.518N     P=0.690      P=0.566N     | 
|LOGISTIC REGRESSION|     P=0.245      P=0.535      P=0.506      P=0.288     |P=0.450N     P=0.477N     P=0.682N     P=0.457N     | 
|COCH-ARM / FISHERS |     P=0.243      P=0.500      P=0.500      P=0.309     |P=0.446N     P=0.492N     P=0.684N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.198      (e)          (e)          (e)         |P=0.500N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      2/38.97      0/41.34      2/40.71     |0/44.22      0/43.87      0/44.80      0/39.65      | 
|POLY-3 PERCENT (g) |     0.0%         5.1%         0.0%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    1/19 (5%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          565          ---          432         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.271      P=0.188      (e)          P=0.228     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.279      P=0.206      (e)          P=0.215     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.294      P=0.220      (e)          P=0.225     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.256      P=0.188      (e)          P=0.201     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.379      P=0.285      (e)          P=0.528     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.313      P=0.247      (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.100      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |3/49 (6%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      2/41.80      0/39.41     |3/44.22      1/43.87      0/44.80      0/39.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         0.0%        |6.8%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    1/21 (5%)    0/16 (0%)   |3/36 (8%)    1/30 (3%)    0/32 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          593          ---         |730 (T)      730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.484      (e)          P=0.191      (e)         |P=0.066N     P=0.372N     P=0.142N     P=0.201N     | 
|POLY 3             |     P=0.500      (e)          P=0.221      (e)         |P=0.043N*    P=0.308N     P=0.116N     P=0.139N     | 
|POLY 1.5           |     P=0.522      (e)          P=0.227      (e)         |P=0.043N*    P=0.303N     P=0.116N     P=0.131N     | 
|POLY 6             |     P=0.465      (e)          P=0.213      (e)         |P=0.042N*    P=0.316N     P=0.117N     P=0.152N     | 
|LOGISTIC REGRESSION|     P=0.557      (e)          P=0.266      (e)         |P=0.066N     P=0.372N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.546      (e)          P=0.247      (e)         |P=0.043N*    P=0.301N     P=0.117N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.235      (e)          (e)          (e)         |P=0.028N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/49 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      1/41.44      0/39.41     |1/44.22      2/43.89      2/44.92      2/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         0.0%        |2.3%         4.6%         4.5%         4.9%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |1/36 (3%)    1/30 (3%)    1/32 (3%)    2/25 (8%)    | 
|FIRST INCIDENCE    |     ---          ---          705          ---         |730 (T)      726          698          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.622      (e)          P=0.462      (e)         |P=0.301      P=0.448      P=0.470      P=0.373      | 
|POLY 3             |     P=0.621      (e)          P=0.483      (e)         |P=0.382      P=0.497      P=0.506      P=0.471      | 
|POLY 1.5           |     P=0.638      (e)          P=0.490      (e)         |P=0.401      P=0.502      P=0.506      P=0.486      | 
|POLY 6             |     P=0.593      (e)          P=0.475      (e)         |P=0.357      P=0.490      P=0.504      P=0.450      | 
|LOGISTIC REGRESSION|     P=0.640      (e)          P=0.481      (e)         |P=0.340      P=0.465      P=0.502      P=0.373      | 
|COCH-ARM / FISHERS |     P=0.657      (e)          P=0.500      (e)         |P=0.429      P=0.508      P=0.508      P=0.508      | 
|ORDER RESTRICTED   |     P=0.367      (e)          (e)          (e)         |P=0.428      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/49 (4%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.14      0/38.44      0/41.34      0/39.41     |2/44.22      3/44.13      1/44.90      1/40.73      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |4.5%         6.8%         2.2%         2.5%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |2/36 (6%)    1/30 (3%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     705          ---          ---          ---         |730 (T)      691          703          712          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.378N     P=0.612N     P=0.538N     P=0.593N    |P=0.376N     P=0.437      P=0.530N     P=0.618N     | 
|POLY 3             |     P=0.318N     P=0.532N     P=0.517N     P=0.527N    |P=0.301N     P=0.499      P=0.495N     P=0.529N     | 
|POLY 1.5           |     P=0.329N     P=0.518N     P=0.510N     P=0.515N    |P=0.290N     P=0.504      P=0.494N     P=0.514N     | 
|POLY 6             |     P=0.302N     P=0.553N     P=0.527N     P=0.544N    |P=0.314N     P=0.492      P=0.496N     P=0.548N     | 
|LOGISTIC REGRESSION|     P=0.360N     P=0.552N     P=0.519N     P=0.540N    |P=0.313N     P=0.489      P=0.498N     P=0.576N     | 
|COCH-ARM / FISHERS |     P=0.343N     P=0.500N     P=0.500N     P=0.500N    |P=0.274N     P=0.510      P=0.492N     P=0.492N     | 
|ORDER RESTRICTED   |     P=0.146N     (e)          (e)          (e)         |P=0.354N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    3/50 (6%)    3/50 (6%)   |9/49 (18%)   7/50 (14%)   7/50 (14%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     6/45.04      4/38.76      3/41.34      3/39.80     |9/45.00      7/44.74      7/45.65      3/40.65      | 
|POLY-3 PERCENT (g) |     13.3%        10.3%        7.3%         7.5%        |20.0%        15.7%        15.3%        7.4%         | 
|TERMINAL (d)       |     6/29 (21%)   3/19 (16%)   3/21 (14%)   1/16 (6%)   |7/36 (19%)   4/30 (13%)   4/32 (13%)   3/25 (12%)   | 
|FIRST INCIDENCE    |     729 (T)      642          729 (T)      642         |509          481          563          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.414N     P=0.636N     P=0.418N     P=0.554N    |P=0.136N     P=0.515N     P=0.458N     P=0.172N     | 
|POLY 3             |     P=0.221N     P=0.467N     P=0.285N     P=0.306N    |P=0.072N     P=0.397N     P=0.380N     P=0.084N     | 
|POLY 1.5           |     P=0.212N     P=0.423N     P=0.267N     P=0.277N    |P=0.062N     P=0.387N     P=0.380N     P=0.071N     | 
|POLY 6             |     P=0.237N     P=0.531N     P=0.308N     P=0.349N    |P=0.088N     P=0.414N     P=0.381N     P=0.105N     | 
|LOGISTIC REGRESSION|     P=0.292N     P=0.620      P=0.418N     P=0.427N    |P=0.056N     P=0.376N     P=0.376N     P=0.083N     | 
|COCH-ARM / FISHERS |     P=0.201N     P=0.370N     P=0.243N     P=0.243N    |P=0.047N*    P=0.376N     P=0.376N     P=0.056N     | 
|ORDER RESTRICTED   |     P=0.280N     (e)          (e)          (e)         |P=0.078N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    5/50 (10%)   3/50 (6%)   |5/49 (10%)   9/50 (18%)   5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     7/45.81      3/39.31      5/42.36      3/39.60     |5/45.53      9/44.30      5/44.80      6/41.28      | 
|POLY-3 PERCENT (g) |     15.3%        7.6%         11.8%        7.6%        |11.0%        20.3%        11.2%        14.5%        | 
|TERMINAL (d)       |     4/29 (14%)   1/19 (5%)    2/21 (10%)   1/16 (6%)   |3/36 (8%)    8/30 (27%)   5/32 (16%)   2/25 (8%)    | 
|FIRST INCIDENCE    |     626          582          509          684         |481          606          730 (T)      647          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.393N     P=0.348N     P=0.547N     P=0.397N    |P=0.389      P=0.127      P=0.570      P=0.329      | 
|POLY 3             |     P=0.253N     P=0.226N     P=0.435N     P=0.222N    |P=0.519      P=0.176      P=0.620      P=0.431      | 
|POLY 1.5           |     P=0.239N     P=0.194N     P=0.411N     P=0.192N    |P=0.555      P=0.188      P=0.628      P=0.464      | 
|POLY 6             |     P=0.278N     P=0.278N     P=0.466N     P=0.271N    |P=0.476      P=0.161      P=0.609      P=0.393      | 
|LOGISTIC REGRESSION|     P=0.239N     P=0.158N     P=0.364N     P=0.233N    |P=0.545N     P=0.210      P=0.613N     P=0.544      | 
|COCH-ARM / FISHERS |     P=0.225N     P=0.159N     P=0.380N     P=0.159N    |P=0.502N     P=0.205      P=0.617N     P=0.514      | 
|ORDER RESTRICTED   |     P=0.193N     (e)          (e)          (e)         |P=0.446      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.04      0/38.44      0/41.34      1/39.59     |0/44.22      0/43.87      2/45.63      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         2.5%        |0.0%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          684         |---          ---          610          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.493      P=0.584N     P=0.564N     P=0.662     |P=0.583      (e)          P=0.249      (e)          | 
|POLY 3             |     P=0.548      P=0.531N     P=0.517N     P=0.731     |P=0.539      (e)          P=0.244      (e)          | 
|POLY 1.5           |     P=0.548      P=0.518N     P=0.510N     P=0.744     |P=0.564      (e)          P=0.243      (e)          | 
|POLY 6             |     P=0.548      P=0.552N     P=0.526N     P=0.712     |P=0.505      (e)          P=0.246      (e)          | 
|LOGISTIC REGRESSION|     P=0.517      (e)          (e)          P=0.720     |P=0.683      (e)          P=0.262      (e)          | 
|COCH-ARM / FISHERS |     P=0.546      P=0.500N     P=0.500N     P=0.753N    |P=0.598      (e)          P=0.253      (e)          | 
|ORDER RESTRICTED   |     P=0.371      (e)          (e)          (e)         |P=0.254      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |2/49 (4%)    5/50 (10%)   6/50 (12%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/45.77      3/39.52      1/41.69      2/39.74     |2/44.78      5/44.27      6/46.01      1/40.87      | 
|POLY-3 PERCENT (g) |     6.6%         7.6%         2.4%         5.0%        |4.5%         11.3%        13.0%        2.5%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    1/30 (3%)    2/32 (6%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     576          621          633          667         |582          670          565          674          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.393N     P=0.536      P=0.371N     P=0.652N    |P=0.439N     P=0.192      P=0.128      P=0.557N     | 
|POLY 3             |     P=0.352N     P=0.593      P=0.339N     P=0.564N    |P=0.390N     P=0.211      P=0.142      P=0.532N     | 
|POLY 1.5           |     P=0.338N     P=0.623      P=0.325N     P=0.536N    |P=0.357N     P=0.217      P=0.141      P=0.516N     | 
|POLY 6             |     P=0.373N     P=0.549      P=0.357N     P=0.603N    |P=0.434N     P=0.202      P=0.142      P=0.553N     | 
|LOGISTIC REGRESSION|     P=0.287N     P=0.525N     P=0.226N     P=0.450N    |P=0.289N     P=0.227      P=0.146      P=0.450N     | 
|COCH-ARM / FISHERS |     P=0.321N     P=0.661N     P=0.309N     P=0.500N    |P=0.311N     P=0.226      P=0.141      P=0.492N     | 
|ORDER RESTRICTED   |     P=0.391N     (e)          (e)          (e)         |P=0.174N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      3/42.04      2/39.71     |0/44.22      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         7.1%         5.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    1/21 (5%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          558          675         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.058      (e)          P=0.094      P=0.170     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.064      (e)          P=0.106      P=0.210     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.070      (e)          P=0.111      P=0.222     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.056      (e)          P=0.101      P=0.195     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.079      (e)          P=0.143      P=0.217     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.078      (e)          P=0.121      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.072      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Regeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      0/41.34      1/39.73     |0/44.22      0/43.87      0/44.80      3/41.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.5%        |0.0%         0.0%         0.0%         7.3%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          642         |---          ---          ---          606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.179      (e)          (e)          P=0.465     |P=0.007 **   (e)          (e)          P=0.083      | 
|POLY 3             |     P=0.180      (e)          (e)          P=0.475     |P=0.010 *    (e)          (e)          P=0.106      | 
|POLY 1.5           |     P=0.184      (e)          (e)          P=0.486     |P=0.011 *    (e)          (e)          P=0.112      | 
|POLY 6             |     P=0.175      (e)          (e)          P=0.460     |P=0.010 *    (e)          (e)          P=0.098      | 
|LOGISTIC REGRESSION|     P=0.198      (e)          (e)          P=0.564     |P=0.012 *    (e)          (e)          P=0.120      | 
|COCH-ARM / FISHERS |     P=0.188      (e)          (e)          P=0.500     |P=0.012 *    (e)          (e)          P=0.125      | 
|ORDER RESTRICTED   |     P=0.101      (e)          (e)          (e)         |P=0.006 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Periportal                                                                                                                | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.25      0/38.44      2/41.34      0/39.41     |0/44.22      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    2/21 (10%)   0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     674          ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.601N     P=0.628N     P=0.410      P=0.551N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.532N     P=0.532N     P=0.469      P=0.527N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.525N     P=0.518N     P=0.482      P=0.515N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.545N     P=0.553N     P=0.452      P=0.545N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.561N     P=0.489N     P=0.456      P=0.485N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.518N     P=0.500N     P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.321N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   6/50 (12%)   4/49 (8%)   |1/49 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/45.04      5/40.17      6/42.31      4/39.14     |1/44.71      2/43.87      1/44.80      1/40.65      | 
|POLY-3 PERCENT (g) |     11.1%        12.5%        14.2%        10.2%       |2.2%         4.6%         2.2%         2.5%         | 
|TERMINAL (d)       |     5/29 (17%)   1/19 (5%)    0/21 (0%)    1/16 (6%)   |0/36 (0%)    2/30 (7%)    1/32 (3%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      537          642          683         |582          730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.495      P=0.430      P=0.340      P=0.470     |P=0.621N     P=0.458      P=0.747      P=0.712      | 
|POLY 3             |     P=0.514N     P=0.557      P=0.456      P=0.587N    |P=0.556N     P=0.493      P=0.760N     P=0.739      | 
|POLY 1.5           |     P=0.488N     P=0.589      P=0.473      P=0.555N    |P=0.544N     P=0.500      P=0.758N     P=0.750      | 
|POLY 6             |     P=0.550N     P=0.511      P=0.440      P=0.631N    |P=0.572N     P=0.483      P=0.758      P=0.724      | 
|LOGISTIC REGRESSION|     P=0.478N     P=0.622N     P=0.431      P=0.579     |P=0.543N     P=0.514      P=0.751N     P=0.737N     | 
|COCH-ARM / FISHERS |     P=0.454N     P=0.630N     P=0.500      P=0.513N    |P=0.525N     P=0.508      P=0.747N     P=0.747N     | 
|ORDER RESTRICTED   |     P=0.581N     (e)          (e)          (e)         |P=0.605N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      0/41.34      2/39.18     |0/44.22      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         5.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          645         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.044 *    (e)          (e)          P=0.193     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.039 *    (e)          (e)          P=0.207     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.040 *    (e)          (e)          P=0.218     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.038 *    (e)          (e)          P=0.193     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.043 *    (e)          (e)          P=0.256     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.042 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.020 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  3/50 (6%)    6/50 (12%)   7/49 (14%)  |3/49 (6%)    1/50 (2%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     10/45.49     3/38.76      6/41.34      7/40.21     |3/44.95      1/44.34      1/44.80      3/40.65      | 
|POLY-3 PERCENT (g) |     22.0%        7.7%         14.5%        17.4%       |6.7%         2.3%         2.2%         7.4%         | 
|TERMINAL (d)       |     8/29 (28%)   2/19 (11%)   6/21 (29%)   3/16 (19%)  |1/36 (3%)    0/30 (0%)    1/32 (3%)    3/25 (12%)   | 
|FIRST INCIDENCE    |     670          642          729 (T)      522         |537          593          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.305      P=0.157N     P=0.433N     P=0.521     |P=0.394      P=0.330N     P=0.327N     P=0.516      | 
|POLY 3             |     P=0.532N     P=0.065N     P=0.267N     P=0.398N    |P=0.475      P=0.310N     P=0.306N     P=0.615      | 
|POLY 1.5           |     P=0.530N     P=0.050N     P=0.241N     P=0.360N    |P=0.488      P=0.305N     P=0.303N     P=0.639      | 
|POLY 6             |     P=0.541N     P=0.094N     P=0.306N     P=0.455N    |P=0.460      P=0.319N     P=0.311N     P=0.583      | 
|LOGISTIC REGRESSION|     P=0.486      P=0.118N     P=0.331N     P=0.389N    |P=0.517      P=0.274N     P=0.291N     P=0.658      | 
|COCH-ARM / FISHERS |     P=0.530N     P=0.036N*    P=0.207N     P=0.314N    |P=0.507      P=0.301N     P=0.301N     P=0.651N     | 
|ORDER RESTRICTED   |     P=0.203N     (e)          (e)          (e)         |P=0.339      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/49 (0%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      2/41.47      0/38.70     |0/44.22      1/44.34      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         0.0%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    1/21 (5%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          696          ---         |---          593          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.473      (e)          P=0.193      (e)         |P=0.579N     P=0.504      (e)          (e)          | 
|POLY 3             |     P=0.498      (e)          P=0.219      (e)         |P=0.570N     P=0.501      (e)          (e)          | 
|POLY 1.5           |     P=0.518      (e)          P=0.226      (e)         |P=0.568N     P=0.502      (e)          (e)          | 
|POLY 6             |     P=0.466      (e)          P=0.210      (e)         |P=0.572N     P=0.497      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.508      (e)          P=0.207      (e)         |P=0.486N     P=0.521      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.541      (e)          P=0.247      (e)         |P=0.565N     P=0.505      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.233      (e)          (e)          (e)         |P=0.396N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  11/50 (22%)  7/50 (14%)   5/49 (10%)  |22/49 (45%)  14/50 (28%)  13/50 (26%)  15/50 (30%)  | 
|POLY-3 RATE (b)    |     13/46.26     11/39.07     7/42.98      5/38.85     |22/45.12     14/45.47     13/45.06     15/43.99     | 
|POLY-3 PERCENT (g) |     28.1%        28.2%        16.3%        12.9%       |48.8%        30.8%        28.9%        34.1%        | 
|TERMINAL (d)       |     7/29 (24%)   9/19 (47%)   4/21 (19%)   4/16 (25%)  |18/36 (50%)  8/30 (27%)   11/32 (34%)  7/25 (28%)   | 
|FIRST INCIDENCE    |     576          642          509          691         |606          481          689          285          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.096N     P=0.322      P=0.265N     P=0.244N    |P=0.436N     P=0.195N     P=0.096N     P=0.453N     | 
|POLY 3             |     P=0.026N*    P=0.594      P=0.137N     P=0.072N    |P=0.136N     P=0.059N     P=0.039N*    P=0.113N     | 
|POLY 1.5           |     P=0.022N*    P=0.513N     P=0.123N     P=0.053N    |P=0.126N     P=0.058N     P=0.038N*    P=0.102N     | 
|POLY 6             |     P=0.034N*    P=0.468      P=0.160N     P=0.109N    |P=0.152N     P=0.064N     P=0.042N*    P=0.136N     | 
|LOGISTIC REGRESSION|     P=0.030N*    P=0.467      P=0.095N     P=0.091N    |P=0.149N     P=0.070N     P=0.038N*    P=0.111N     | 
|COCH-ARM / FISHERS |     P=0.018N*    P=0.408N     P=0.105N     P=0.037N*   |P=0.117N     P=0.062N     P=0.039N*    P=0.093N     | 
|ORDER RESTRICTED   |     P=0.060N     (e)          (e)          (e)         |P=0.058N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   2/50 (4%)    1/49 (2%)   |2/49 (4%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.05      5/40.23      2/41.34      1/38.77     |2/44.82      2/44.85      2/44.88      2/40.93      | 
|POLY-3 PERCENT (g) |     2.2%         12.4%        4.8%         2.6%        |4.5%         4.5%         4.5%         4.9%         | 
|TERMINAL (d)       |     0/29 (0%)    1/19 (5%)    2/21 (10%)   0/16 (0%)   |1/36 (3%)    0/30 (0%)    1/32 (3%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     726          421          729 (T)      712         |537          575          710          656          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.354N     P=0.055      P=0.390      P=0.626     |P=0.515      P=0.681      P=0.668      P=0.608      | 
|POLY 3             |     P=0.312N     P=0.077      P=0.470      P=0.726     |P=0.553      P=0.694N     P=0.693N     P=0.661      | 
|POLY 1.5           |     P=0.285N     P=0.087      P=0.482      P=0.740     |P=0.572      P=0.690N     P=0.691N     P=0.677      | 
|POLY 6             |     P=0.353N     P=0.063      P=0.455      P=0.707     |P=0.528      P=0.689      P=0.691      P=0.639      | 
|LOGISTIC REGRESSION|     P=0.235N     P=0.192      P=0.405      P=0.681     |P=0.523N     P=0.667N     P=0.683N     P=0.659N     | 
|COCH-ARM / FISHERS |     P=0.254N     P=0.102      P=0.500      P=0.747     |P=0.590N     P=0.684N     P=0.684N     P=0.684N     | 
|ORDER RESTRICTED   |     P=0.291N     (e)          (e)          (e)         |P=0.703      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Bronchial                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/15 (7%)    1/12 (8%)    0/16 (0%)    0/13 (0%)   |0/12 (0%)    0/7 (0%)     2/8 (25%)    0/11 (0%)    | 
|POLY-3 RATE (b)    |     1/13.77      1/10.20      0/12.55      0/11.23     |0/9.43       0/5.24       2/6.96       0/8.09       | 
|POLY-3 PERCENT (g) |     7.3%         9.8%         0.0%         0.0%        |0.0%         0.0%         28.7%        0.0%         | 
|TERMINAL (d)       |     0/7 (0%)     1/5 (20%)    0/4 (0%)     0/4 (0%)    |0/7 (0%)     0/3 (0%)     2/5 (40%)    0/3 (0%)     | 
|FIRST INCIDENCE    |     674          729 (T)      ---          ---         |---          ---          730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256N     P=0.648      P=0.527N     P=0.551N    |P=0.455      (e)          P=0.158      (e)          | 
|POLY 3             |     P=0.226N     P=0.693      P=0.518N     P=0.541N    |P=0.553      (e)          P=0.149      (e)          | 
|POLY 1.5           |     P=0.220N     P=0.701      P=0.505N     P=0.535N    |P=0.577      (e)          P=0.143      (e)          | 
|POLY 6             |     P=0.236N     P=0.680      P=0.537N     P=0.551N    |P=0.506      (e)          P=0.153      (e)          | 
|LOGISTIC REGRESSION|     P=0.223N     P=0.708      P=0.462N     P=0.480N    |(e)          (e)          P=0.158      (e)          | 
|COCH-ARM / FISHERS |     P=0.209N     P=0.701      P=0.484N     P=0.536N    |P=0.595      (e)          P=0.147      (e)          | 
|ORDER RESTRICTED   |     P=0.238N     (e)          (e)          (e)         |P=0.166      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/42 (0%)    0/44 (0%)    2/43 (5%)    0/40 (0%)   |0/45 (0%)    1/39 (3%)    0/42 (0%)    0/45 (0%)    | 
|POLY-3 RATE (b)    |     0/38.05      0/35.31      2/35.13      0/31.74     |0/40.22      1/33.18      0/37.39      0/37.14      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         5.7%         0.0%        |0.0%         3.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/19 (0%)    2/16 (13%)   0/14 (0%)   |0/32 (0%)    1/22 (5%)    0/28 (0%)    0/24 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.418      (e)          P=0.132      (e)         |P=0.596N     P=0.425      (e)          (e)          | 
|POLY 3             |     P=0.485      (e)          P=0.219      (e)         |P=0.569N     P=0.462      (e)          (e)          | 
|POLY 1.5           |     P=0.505      (e)          P=0.229      (e)         |P=0.565N     P=0.466      (e)          (e)          | 
|POLY 6             |     P=0.455      (e)          P=0.206      (e)         |P=0.573N     P=0.455      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.132      (e)         |(e)          P=0.425      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.532      (e)          P=0.253      (e)         |P=0.560N     P=0.464      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.235      (e)          (e)          (e)         |P=0.363N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      2/42.04      0/39.41     |0/44.62      0/43.87      0/44.80      1/40.30      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         0.0%        |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          558          ---         |---          ---          ---          549          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.524      (e)          P=0.216      (e)         |P=0.190      (e)          (e)          P=0.491      | 
|POLY 3             |     P=0.499      (e)          P=0.222      (e)         |P=0.186      (e)          (e)          P=0.480      | 
|POLY 1.5           |     P=0.521      (e)          P=0.228      (e)         |P=0.190      (e)          (e)          P=0.486      | 
|POLY 6             |     P=0.464      (e)          P=0.215      (e)         |P=0.182      (e)          (e)          P=0.471      | 
|LOGISTIC REGRESSION|     P=0.579      (e)          P=0.312      (e)         |P=0.284      (e)          (e)          P=0.614      | 
|COCH-ARM / FISHERS |     P=0.546      (e)          P=0.247      (e)         |P=0.195      (e)          (e)          P=0.495      | 
|ORDER RESTRICTED   |     P=0.236      (e)          (e)          (e)         |P=0.104      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/45.55      2/38.66      3/41.36      2/39.83     |1/44.62      0/43.87      2/44.81      2/40.65      | 
|POLY-3 PERCENT (g) |     6.6%         5.2%         7.3%         5.0%        |2.2%         0.0%         4.5%         4.9%         | 
|TERMINAL (d)       |     2/29 (7%)    1/19 (5%)    2/21 (10%)   1/16 (6%)   |1/36 (3%)    0/30 (0%)    1/32 (3%)    2/25 (8%)    | 
|FIRST INCIDENCE    |     576          670          726          610         |730 (T)      ---          726          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.512      P=0.667N     P=0.524      P=0.673     |P=0.161      P=0.536N     P=0.463      P=0.373      | 
|POLY 3             |     P=0.511N     P=0.574N     P=0.617      P=0.561N    |P=0.218      P=0.503N     P=0.501      P=0.468      | 
|POLY 1.5           |     P=0.496N     P=0.542N     P=0.636      P=0.534N    |P=0.229      P=0.502N     P=0.501      P=0.481      | 
|POLY 6             |     P=0.535N     P=0.620N     P=0.593      P=0.598N    |P=0.205      P=0.507N     P=0.501      P=0.449      | 
|LOGISTIC REGRESSION|     P=0.519N     P=0.529N     P=0.626      P=0.468N    |P=0.164      (e)          P=0.480      P=0.373      | 
|COCH-ARM / FISHERS |     P=0.479N     P=0.500N     P=0.661N     P=0.500N    |P=0.245      P=0.500N     P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.594N     (e)          (e)          (e)         |P=0.240      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/7 (100%)   11/11 (100%) 11/11 (100%) 12/13 (92%) |11/11 (100%) 15/15 (100%) 23/23 (100%) 13/14 (93%)  | 
|POLY-3 RATE (b)    |     7/7.00       11/11.00     11/11.00     12/12.46    |11/11.00     15/15.00     23/23.00     13/13.79     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       96.3%       |100.0%       100.0%       100.0%       94.3%        | 
|TERMINAL (d)       |     4/4 (100%)   5/5 (100%)   3/3 (100%)   5/5 (100%)  |8/8 (100%)   8/8 (100%)   15/15 (100%) 8/8 (100%)   | 
|FIRST INCIDENCE    |     621          565          509          465         |495          593          565          506          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.115      (e)          (e)          P=0.084     |P=0.278      (e)          (e)          P=0.272      | 
|POLY 3             |     P=0.501N     (e)          (e)          P=0.928N    |P=0.255N     (e)          (e)          P=0.648N     | 
|POLY 1.5           |     P=0.340N     (e)          (e)          P=0.781N    |P=0.223N     (e)          (e)          P=0.596N     | 
|POLY 6             |     P=0.933N     (e)          (e)          P=1.000N    |P=0.341N     (e)          (e)          P=0.762N     | 
|LOGISTIC REGRESSION|     P=0.361N     (e)          (e)          P=0.909N    |P=0.194N     (e)          (e)          P=0.537N     | 
|COCH-ARM / FISHERS |     P=0.239N     (e)          (e)          P=0.650N    |P=0.196N     (e)          (e)          P=0.560N     | 
|ORDER RESTRICTED   |     P=0.265N     (e)          (e)          (e)         |P=0.164N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |2/49 (4%)    2/50 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.41      3/39.28      1/41.47      2/39.51     |2/44.65      2/43.98      0/43.98      0/40.65      | 
|POLY-3 PERCENT (g) |     4.4%         7.6%         2.4%         5.1%        |4.5%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    0/21 (0%)    1/16 (6%)   |1/36 (3%)    1/30 (3%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     626          621          698          705         |606          703          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.553N     P=0.345      P=0.567N     P=0.523     |P=0.113N     P=0.652      P=0.250N     P=0.288N     | 
|POLY 3             |     P=0.494N     P=0.434      P=0.532N     P=0.643     |P=0.090N     P=0.689      P=0.240N     P=0.259N     | 
|POLY 1.5           |     P=0.476N     P=0.463      P=0.519N     P=0.666     |P=0.088N     P=0.693N     P=0.239N     P=0.248N     | 
|POLY 6             |     P=0.521N     P=0.395      P=0.548N     P=0.609     |P=0.093N     P=0.679      P=0.242N     P=0.274N     | 
|LOGISTIC REGRESSION|     P=0.462N     P=0.569      P=0.492N     P=0.655     |P=0.084N     P=0.686N     P=0.232N     P=0.213N     | 
|COCH-ARM / FISHERS |     P=0.454N     P=0.500      P=0.500N     P=0.691N    |P=0.085N     P=0.684N     P=0.247N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.501N     (e)          (e)          (e)         |P=0.131N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    2/50 (4%)    5/50 (10%)  |1/49 (2%)    5/50 (10%)   3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.41      4/39.06      2/41.94      5/40.45     |1/44.22      5/43.98      3/43.98      0/40.65      | 
|POLY-3 PERCENT (g) |     8.8%         10.2%        4.8%         12.4%       |2.3%         11.4%        6.8%         0.0%         | 
|TERMINAL (d)       |     3/29 (10%)   2/19 (11%)   0/21 (0%)    1/16 (6%)   |1/36 (3%)    4/30 (13%)   3/32 (9%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     626          621          589          581         |730 (T)      703          730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.305      P=0.435      P=0.445N     P=0.264     |P=0.297N     P=0.071      P=0.263      P=0.573N     | 
|POLY 3             |     P=0.422      P=0.558      P=0.374N     P=0.428     |P=0.235N     P=0.100      P=0.303      P=0.517N     | 
|POLY 1.5           |     P=0.438      P=0.596      P=0.359N     P=0.459     |P=0.215N     P=0.103      P=0.304      P=0.508N     | 
|POLY 6             |     P=0.398      P=0.503      P=0.393N     P=0.385     |P=0.263N     P=0.095      P=0.302      P=0.528N     | 
|LOGISTIC REGRESSION|     P=0.446      P=0.567      P=0.320N     P=0.489     |P=0.266N     P=0.087      P=0.263      (e)          | 
|COCH-ARM / FISHERS |     P=0.457      P=0.643N     P=0.339N     P=0.500     |P=0.190N     P=0.107      P=0.309      P=0.495N     | 
|ORDER RESTRICTED   |     P=0.371      (e)          (e)          (e)         |P=0.122N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Goblet Cell                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    4/50 (8%)   |1/49 (2%)    3/50 (6%)    3/49 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.04      1/38.67      1/41.45      4/39.56     |1/44.22      3/43.87      3/43.98      1/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         2.6%         2.4%         10.1%       |2.3%         6.8%         6.8%         2.5%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    0/21 (0%)    3/16 (19%)  |1/36 (3%)    3/30 (10%)   3/32 (9%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      667          702          691         |730 (T)      730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029 *    P=0.654      P=0.707      P=0.056     |P=0.562      P=0.242      P=0.263      P=0.678      | 
|POLY 3             |     P=0.056      P=0.726      P=0.742      P=0.141     |P=0.548N     P=0.302      P=0.303      P=0.742      | 
|POLY 1.5           |     P=0.060      P=0.741      P=0.750      P=0.157     |P=0.527N     P=0.307      P=0.304      P=0.751      | 
|POLY 6             |     P=0.051      P=0.702      P=0.733      P=0.120     |P=0.577N     P=0.294      P=0.302      P=0.728      | 
|LOGISTIC REGRESSION|     P=0.044 *    P=0.731      P=0.730      P=0.076     |P=0.562      P=0.242      P=0.263      P=0.678      | 
|COCH-ARM / FISHERS |     P=0.065      P=0.753N     P=0.753N     P=0.181     |P=0.494N     P=0.316      P=0.309      P=0.747N     | 
|ORDER RESTRICTED   |     P=0.049 *    (e)          (e)          (e)         |P=0.391      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/49 (4%)    0/50 (0%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.04      0/38.44      0/41.34      0/39.41     |2/44.22      0/43.87      1/43.98      1/41.13      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |4.5%         0.0%         2.3%         2.4%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |2/36 (6%)    0/30 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |730 (T)      ---          730 (T)      589          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.405N     P=0.584N     P=0.564N     P=0.619N    |P=0.576N     P=0.279N     P=0.541N     P=0.589N     | 
|POLY 3             |     P=0.318N     P=0.531N     P=0.517N     P=0.527N    |P=0.504N     P=0.239N     P=0.502N     P=0.525N     | 
|POLY 1.5           |     P=0.329N     P=0.518N     P=0.510N     P=0.515N    |P=0.501N     P=0.236N     P=0.501N     P=0.512N     | 
|POLY 6             |     P=0.302N     P=0.552N     P=0.526N     P=0.543N    |P=0.505N     P=0.244N     P=0.503N     P=0.543N     | 
|LOGISTIC REGRESSION|     P=0.405N     (e)          (e)          (e)         |P=0.503N     (e)          P=0.541N     P=0.491N     | 
|COCH-ARM / FISHERS |     P=0.343N     P=0.500N     P=0.500N     P=0.500N    |P=0.496N     P=0.242N     P=0.500N     P=0.492N     | 
|ORDER RESTRICTED   |     P=0.145N     (e)          (e)          (e)         |P=0.292N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    8/50 (16%)   2/50 (4%)    3/50 (6%)   |12/49 (24%)  18/50 (36%)  15/49 (31%)  28/50 (56%)  | 
|POLY-3 RATE (b)    |     2/45.04      8/40.75      2/41.39      3/39.71     |12/46.19     18/45.33     15/45.52     28/46.89     | 
|POLY-3 PERCENT (g) |     4.4%         19.6%        4.8%         7.6%        |26.0%        39.7%        33.0%        59.7%        | 
|TERMINAL (d)       |     2/29 (7%)    2/19 (11%)   1/21 (5%)    1/16 (6%)   |9/36 (25%)   13/30 (43%)  10/32 (31%)  14/25 (56%)  | 
|FIRST INCIDENCE    |     729 (T)      565          717          675         |481          481          581          285          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.433N     P=0.017 *    P=0.580      P=0.288     |P<0.001 **   P=0.068      P=0.253      P<0.001 **   | 
|POLY 3             |     P=0.349N     P=0.030 *    P=0.663      P=0.443     |P<0.001 **   P=0.117      P=0.307      P<0.001 **   | 
|POLY 1.5           |     P=0.317N     P=0.036 *    P=0.676      P=0.468     |P<0.001 **   P=0.131      P=0.312      P<0.001 **   | 
|POLY 6             |     P=0.395N     P=0.023 *    P=0.648      P=0.408     |P<0.001 **   P=0.100      P=0.309      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.285N     P=0.066      P=0.614      P=0.368     |P=0.002 **   P=0.156      P=0.330      P=0.004 **   | 
|COCH-ARM / FISHERS |     P=0.281N     P=0.046 *    P=0.691N     P=0.500     |P<0.001 **   P=0.152      P=0.326      P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.243      (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.41      1/38.82      1/41.34      1/39.41     |0/44.22      0/43.87      0/43.98      0/40.65      | 
|POLY-3 PERCENT (g) |     8.8%         2.6%         2.4%         2.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/29 (10%)   0/19 (0%)    1/21 (5%)    1/16 (6%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     626          621          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.271N     P=0.288N     P=0.275N     P=0.359N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.167N     P=0.230N     P=0.208N     P=0.224N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.167N     P=0.206N     P=0.196N     P=0.204N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.169N     P=0.267N     P=0.225N     P=0.257N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.192N     P=0.188N     P=0.213N     P=0.249N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.169N     P=0.181N     P=0.181N     P=0.181N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.109N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    2/50 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      0/41.34      0/39.41     |0/44.22      2/43.87      0/43.98      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    2/30 (7%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.469N     P=0.199      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.421N     P=0.235      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.413N     P=0.238      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.432N     P=0.230      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.199      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.402N     P=0.253      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.262N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |8/50 (16%)   9/50 (18%)   8/50 (16%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |                                                        |8/45.78      9/44.10      8/44.96      5/40.73      | 
|POLY-3 PERCENT (g) |                                                        |17.5%        20.4%        17.8%        12.3%        | 
|TERMINAL (d)       |                                                        |5/36 (14%)   8/30 (27%)   7/32 (22%)   4/25 (16%)   | 
|FIRST INCIDENCE    |                                                        |540          670          689          712          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.400N     P=0.370      P=0.529      P=0.498N     | 
|POLY 3             |                                                        |P=0.265N     P=0.466      P=0.593      P=0.355N     | 
|POLY 1.5           |                                                        |P=0.235N     P=0.482      P=0.598      P=0.322N     | 
|POLY 6             |                                                        |P=0.309N     P=0.442      P=0.583      P=0.403N     | 
|LOGISTIC REGRESSION|                                                        |P=0.263N     P=0.490      P=0.606N     P=0.323N     | 
|COCH-ARM / FISHERS |                                                        |P=0.192N     P=0.500      P=0.607N     P=0.277N     | 
|ORDER RESTRICTED   |                                                        |P=0.331N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |2/49 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.05      2/38.82      1/41.34      2/39.59     |2/44.22      1/43.89      1/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     4.4%         5.2%         2.4%         5.1%        |4.5%         2.3%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    1/19 (5%)    1/21 (5%)    1/16 (6%)   |2/36 (6%)    0/30 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     726          621          729 (T)      684         |730 (T)      726          730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.490      P=0.566      P=0.610N     P=0.497     |P=0.209N     P=0.552N     P=0.541N     P=0.322N     | 
|POLY 3             |     P=0.585N     P=0.639      P=0.530N     P=0.647     |P=0.162N     P=0.503N     P=0.495N     P=0.256N     | 
|POLY 1.5           |     P=0.574N     P=0.664      P=0.518N     P=0.668     |P=0.158N     P=0.498N     P=0.495N     P=0.247N     | 
|POLY 6             |     P=0.579      P=0.602      P=0.545N     P=0.616     |P=0.167N     P=0.510N     P=0.497N     P=0.270N     | 
|LOGISTIC REGRESSION|     P=0.581      P=0.623      P=0.595N     P=0.572     |P=0.198N     P=0.535N     P=0.541N     (e)          | 
|COCH-ARM / FISHERS |     P=0.561N     P=0.691N     P=0.500N     P=0.691N    |P=0.150N     P=0.492N     P=0.492N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.628N     (e)          (e)          (e)         |P=0.134N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/49 (4%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      0/41.34      0/39.41     |2/45.48      0/43.87      2/45.59      2/40.97      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         4.4%         4.9%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |509          ---          433          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.397      P=0.240N     P=0.683      P=0.645      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.414      P=0.245N     P=0.693N     P=0.656      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.428      P=0.240N     P=0.690N     P=0.674      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.398      P=0.253N     P=0.690      P=0.632      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.601N     P=0.189N     P=0.642N     P=0.569N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.450      P=0.242N     P=0.684N     P=0.684N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.400      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |5/49 (10%)   3/50 (6%)    3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/45.45      0/38.44      1/41.43      1/39.53     |5/44.71      3/44.30      3/45.59      3/41.07      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.4%         2.5%        |11.2%        6.8%         6.6%         7.3%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |4/36 (11%)   2/30 (7%)    2/32 (6%)    2/25 (8%)    | 
|FIRST INCIDENCE    |     611          ---          708          698         |582          606          433          611          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.417      P=0.531N     P=0.721      P=0.686     |P=0.451N     P=0.434N     P=0.408N     P=0.522N     | 
|POLY 3             |     P=0.468      P=0.533N     P=0.740      P=0.729     |P=0.348N     P=0.361N     P=0.346N     P=0.404N     | 
|POLY 1.5           |     P=0.475      P=0.519N     P=0.748      P=0.743     |P=0.334N     P=0.354N     P=0.345N     P=0.380N     | 
|POLY 6             |     P=0.457      P=0.555N     P=0.729      P=0.707     |P=0.366N     P=0.373N     P=0.349N     P=0.436N     | 
|LOGISTIC REGRESSION|     P=0.484      P=0.389N     P=0.732N     P=0.723N    |P=0.289N     P=0.345N     P=0.336N     P=0.374N     | 
|COCH-ARM / FISHERS |     P=0.482      P=0.500N     P=0.753N     P=0.753N    |P=0.311N     P=0.346N     P=0.346N     P=0.346N     | 
|ORDER RESTRICTED   |     P=0.506      (e)          (e)          (e)         |P=0.373N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    3/50 (6%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.04      1/38.97      1/41.40      3/40.50     |0/44.22      0/43.87      0/44.80      1/40.84      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         2.4%         7.4%        |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          565          715          578         |---          ---          ---          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045 *    P=0.487      P=0.459      P=0.091     |P=0.179      (e)          (e)          P=0.468      | 
|POLY 3             |     P=0.050      P=0.471      P=0.483      P=0.100     |P=0.189      (e)          (e)          P=0.484      | 
|POLY 1.5           |     P=0.054      P=0.484      P=0.490      P=0.108     |P=0.193      (e)          (e)          P=0.492      | 
|POLY 6             |     P=0.045 *    P=0.453      P=0.475      P=0.091     |P=0.183      (e)          (e)          P=0.473      | 
|LOGISTIC REGRESSION|     P=0.072      P=0.682      P=0.470      P=0.189     |P=0.202      (e)          (e)          P=0.506      | 
|COCH-ARM / FISHERS |     P=0.059      P=0.500      P=0.500      P=0.121     |P=0.200      (e)          (e)          P=0.505      | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |P=0.107      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   6/50 (12%)   5/50 (10%)  |9/49 (18%)   9/50 (18%)   8/50 (16%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     4/45.41      5/39.05      6/42.91      5/40.28     |9/45.17      9/45.04      8/45.41      8/41.69      | 
|POLY-3 PERCENT (g) |     8.8%         12.8%        14.0%        12.4%       |19.9%        20.0%        17.6%        19.2%        | 
|TERMINAL (d)       |     3/29 (10%)   3/19 (16%)   2/21 (10%)   2/16 (13%)  |6/36 (17%)   6/30 (20%)   5/32 (16%)   4/25 (16%)   | 
|FIRST INCIDENCE    |     626          621          509          548         |537          537          610          549          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.260      P=0.278      P=0.249      P=0.251     |P=0.441      P=0.484      P=0.566N     P=0.458      | 
|POLY 3             |     P=0.381      P=0.406      P=0.334      P=0.425     |P=0.493N     P=0.601      P=0.495N     P=0.573N     | 
|POLY 1.5           |     P=0.408      P=0.447      P=0.348      P=0.458     |P=0.461N     P=0.596N     P=0.490N     P=0.536N     | 
|POLY 6             |     P=0.341      P=0.348      P=0.318      P=0.379     |P=0.533N     P=0.585      P=0.503N     P=0.595      | 
|LOGISTIC REGRESSION|     P=0.430      P=0.382      P=0.431      P=0.469     |P=0.445N     P=0.583N     P=0.484N     P=0.527N     | 
|COCH-ARM / FISHERS |     P=0.440      P=0.500      P=0.370      P=0.500     |P=0.409N     P=0.584N     P=0.482N     P=0.482N     | 
|ORDER RESTRICTED   |     P=0.417      (e)          (e)          (e)         |P=0.657N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    12/50 (24%)  5/50 (10%)   1/50 (2%)   |18/48 (38%)  6/50 (12%)   9/50 (18%)   12/50 (24%)  | 
|POLY-3 RATE (b)    |     2/45.04      12/40.34     5/41.86      1/39.48     |18/44.09     6/44.40      9/45.00      12/43.35     | 
|POLY-3 PERCENT (g) |     4.4%         29.8%        12.0%        2.5%        |40.8%        13.5%        20.0%        27.7%        | 
|TERMINAL (d)       |     2/29 (7%)    7/19 (37%)   3/21 (14%)   0/16 (0%)   |17/36 (47%)  4/30 (13%)   7/32 (22%)   6/25 (24%)   | 
|FIRST INCIDENCE    |     729 (T)      579          618          712         |656          575          689          285          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.122N     P<0.001 **   P=0.126      P=0.694N    |P=0.545      P=0.015N*    P=0.064N     P=0.463N     | 
|POLY 3             |     P=0.065N     P<0.001 **   P=0.187      P=0.546N    |P=0.242N     P=0.003N**   P=0.025N*    P=0.139N     | 
|POLY 1.5           |     P=0.050N     P=0.002 **   P=0.199      P=0.526N    |P=0.233N     P=0.003N**   P=0.025N*    P=0.124N     | 
|POLY 6             |     P=0.093N     P<0.001 **   P=0.173      P=0.575N    |P=0.257N     P=0.003N**   P=0.026N*    P=0.167N     | 
|LOGISTIC REGRESSION|     P=0.052N     P=0.002 **   P=0.171      P=0.653N    |P=0.278N     P=0.005N**   P=0.032N*    P=0.134N     | 
|COCH-ARM / FISHERS |     P=0.041N*    P=0.004 **   P=0.218      P=0.500N    |P=0.226N     P=0.003N**   P=0.026N*    P=0.109N     | 
|ORDER RESTRICTED   |     P=0.027N*    (e)          (e)          (e)         |P=0.016N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  2/50 (4%)    1/50 (2%)    5/50 (10%)  |21/48 (44%)  20/50 (40%)  13/50 (26%)  5/50 (10%)   | 
|POLY-3 RATE (b)    |     11/46.66     2/38.76      1/41.92      5/40.12     |21/44.58     20/45.36     13/45.06     5/41.90      | 
|POLY-3 PERCENT (g) |     23.6%        5.2%         2.4%         12.5%       |47.1%        44.1%        28.9%        11.9%        | 
|TERMINAL (d)       |     5/29 (17%)   1/19 (5%)    0/21 (0%)    2/16 (13%)  |17/36 (47%)  15/30 (50%)  11/32 (34%)  2/25 (8%)    | 
|FIRST INCIDENCE    |     576          642          546          581         |634          481          689          285          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.275N     P=0.059N     P=0.011N*    P=0.330N    |P=0.002N**   P=0.407      P=0.135N     P=0.007N**   | 
|POLY 3             |     P=0.122N     P=0.018N*    P=0.003N**   P=0.145N    |P<0.001N**   P=0.470N     P=0.055N     P<0.001N**   | 
|POLY 1.5           |     P=0.127N     P=0.012N*    P=0.003N**   P=0.116N    |P<0.001N**   P=0.450N     P=0.053N     P<0.001N**   | 
|POLY 6             |     P=0.119N     P=0.032N*    P=0.005N**   P=0.198N    |P<0.001N**   P=0.510N     P=0.062N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.149N     P=0.009N**   P<0.001N**   P=0.093N    |P<0.001N**   P=0.502N     P=0.058N     P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.143N     P=0.007N**   P=0.002N**   P=0.086N    |P<0.001N**   P=0.432N     P=0.051N     P<0.001N**   | 
|ORDER RESTRICTED   |     P=0.006N**   (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/45.11      1/38.82      0/41.34      2/39.94     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         2.6%         0.0%         5.0%        |                                                    | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |                                                    | 
|FIRST INCIDENCE    |     712          621          ---          642         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.332      P=0.689      P=0.546N     P=0.394     |                                                    | 
|POLY 3             |     P=0.356      P=0.726      P=0.517N     P=0.458     |                                                    | 
|POLY 1.5           |     P=0.364      P=0.742      P=0.510N     P=0.476     |                                                    | 
|POLY 6             |     P=0.345      P=0.702      P=0.526N     P=0.432     |                                                    | 
|LOGISTIC REGRESSION|     P=0.386      P=0.749N     P=0.527N     P=0.521     |                                                    | 
|COCH-ARM / FISHERS |     P=0.373      P=0.753N     P=0.500N     P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    4/50 (8%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      4/43.09      0/39.41     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         9.3%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          556          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.404      (e)          P=0.052      (e)         |                                                    | 
|POLY 3             |     P=0.372      (e)          P=0.054      (e)         |                                                    | 
|POLY 1.5           |     P=0.401      (e)          P=0.057      (e)         |                                                    | 
|POLY 6             |     P=0.326      (e)          P=0.052      (e)         |                                                    | 
|LOGISTIC REGRESSION|     P=0.498      (e)          P=0.125      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.436      (e)          P=0.059      (e)         |                                                    | 
|ORDER RESTRICTED   |     P=0.104      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     1/45.04      1/38.72      0/41.34      3/39.92     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         2.6%         0.0%         7.5%        |                                                    | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    0/21 (0%)    1/16 (6%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      652          ---          581         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.101      P=0.668      P=0.564N     P=0.159     |                                                    | 
|POLY 3             |     P=0.152      P=0.726      P=0.517N     P=0.263     |                                                    | 
|POLY 1.5           |     P=0.157      P=0.741      P=0.510N     P=0.281     |                                                    | 
|POLY 6             |     P=0.145      P=0.702      P=0.526N     P=0.238     |                                                    | 
|LOGISTIC REGRESSION|     P=0.155      P=0.750      (e)          P=0.275     |                                                    | 
|COCH-ARM / FISHERS |     P=0.163      P=0.753N     P=0.500N     P=0.309     |                                                    | 
|ORDER RESTRICTED   |     P=0.081      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  10/50 (20%)  14/50 (28%)  12/50 (24%) |                                                    | 
|POLY-3 RATE (b)    |     10/46.65     10/42.64     14/44.71     12/41.80    |                                                    | 
|POLY-3 PERCENT (g) |     21.4%        23.5%        31.3%        28.7%       |                                                    | 
|TERMINAL (d)       |     2/29 (7%)    1/19 (5%)    5/21 (24%)   3/16 (19%)  |                                                    | 
|FIRST INCIDENCE    |     576          421          546          563         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.127      P=0.342      P=0.128      P=0.117     |                                                    | 
|POLY 3             |     P=0.202      P=0.510      P=0.201      P=0.293     |                                                    | 
|POLY 1.5           |     P=0.236      P=0.550      P=0.216      P=0.340     |                                                    | 
|POLY 6             |     P=0.161      P=0.449      P=0.185      P=0.234     |                                                    | 
|LOGISTIC REGRESSION|     P=0.365      P=0.262N     P=0.346      P=0.453     |                                                    | 
|COCH-ARM / FISHERS |     P=0.285      P=0.598N     P=0.241      P=0.405     |                                                    | 
|ORDER RESTRICTED   |     P=0.281      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/45.45      2/38.78      2/41.43      3/39.41     |0/44.62      1/43.87      1/44.80      1/40.73      | 
|POLY-3 PERCENT (g) |     11.0%        5.2%         4.8%         7.6%        |0.0%         2.3%         2.2%         2.5%         | 
|TERMINAL (d)       |     4/29 (14%)   1/19 (5%)    1/21 (5%)    3/16 (19%)  |0/36 (0%)    1/30 (3%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     611          636          708          729 (T)     |---          730 (T)      730 (T)      712          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.559      P=0.377N     P=0.343N     P=0.632     |P=0.308      P=0.464      P=0.477      P=0.441      | 
|POLY 3             |     P=0.402N     P=0.285N     P=0.255N     P=0.437N    |P=0.350      P=0.497      P=0.501      P=0.482      | 
|POLY 1.5           |     P=0.394N     P=0.254N     P=0.239N     P=0.401N    |P=0.364      P=0.498      P=0.500      P=0.489      | 
|POLY 6             |     P=0.416N     P=0.334N     P=0.276N     P=0.491N    |P=0.331      P=0.493      P=0.501      P=0.472      | 
|LOGISTIC REGRESSION|     P=0.466N     P=0.288N     P=0.264N     P=0.526N    |P=0.332      P=0.464      P=0.477      P=0.474      | 
|COCH-ARM / FISHERS |     P=0.387N     P=0.218N     P=0.218N     P=0.357N    |P=0.384      P=0.500      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.284N     (e)          (e)          (e)         |P=0.311      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.27      0/38.44      1/41.66      2/39.65     |1/45.28      0/43.87      1/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.4%         5.0%        |2.2%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     670          ---          642          684         |509          ---          730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.179      P=0.608N     P=0.724      P=0.375     |P=0.438N     P=0.504N     P=0.747      P=0.504N     | 
|POLY 3             |     P=0.202      P=0.532N     P=0.742      P=0.454     |P=0.417N     P=0.506N     P=0.758      P=0.521N     | 
|POLY 1.5           |     P=0.206      P=0.518N     P=0.750      P=0.474     |P=0.413N     P=0.503N     P=0.759      P=0.513N     | 
|POLY 6             |     P=0.195      P=0.554N     P=0.732      P=0.425     |P=0.422N     P=0.511N     P=0.757      P=0.533N     | 
|LOGISTIC REGRESSION|     P=0.206      P=0.482N     P=0.728N     P=0.483     |P=0.338N     P=0.488N     P=0.755N     P=0.338N     | 
|COCH-ARM / FISHERS |     P=0.209      P=0.500N     P=0.753N     P=0.500     |P=0.405N     P=0.500N     P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.192      (e)          (e)          (e)         |P=0.273N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      2/42.40      0/39.41     |0/44.62      0/43.87      0/44.80      1/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.7%         0.0%        |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          396          ---         |---          ---          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.546      (e)          P=0.228      (e)         |P=0.160      (e)          (e)          P=0.427      | 
|POLY 3             |     P=0.498      (e)          P=0.224      (e)         |P=0.188      (e)          (e)          P=0.481      | 
|POLY 1.5           |     P=0.520      (e)          P=0.230      (e)         |P=0.192      (e)          (e)          P=0.489      | 
|POLY 6             |     P=0.462      (e)          P=0.216      (e)         |P=0.182      (e)          (e)          P=0.471      | 
|LOGISTIC REGRESSION|     P=0.609      (e)          P=0.443      (e)         |(e)          (e)          (e)          P=0.427      | 
|COCH-ARM / FISHERS |     P=0.546      (e)          P=0.247      (e)         |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.237      (e)          (e)          (e)         |P=0.105      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Accessory Spleen                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |1/49 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.04      0/38.44      3/41.55      1/39.95     |1/44.82      0/43.87      2/45.71      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         7.2%         2.5%        |2.2%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    1/21 (5%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          691          563         |537          ---          401          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.301      P=0.584N     P=0.227      P=0.686     |P=0.489N     P=0.496N     P=0.496      P=0.509N     | 
|POLY 3             |     P=0.375      P=0.531N     P=0.277      P=0.733     |P=0.488N     P=0.504N     P=0.507      P=0.519N     | 
|POLY 1.5           |     P=0.387      P=0.518N     P=0.288      P=0.746     |P=0.475N     P=0.501N     P=0.507      P=0.510N     | 
|POLY 6             |     P=0.356      P=0.552N     P=0.263      P=0.715     |P=0.503N     P=0.510N     P=0.505      P=0.532N     | 
|LOGISTIC REGRESSION|     P=0.386      (e)          P=0.250      P=0.710N    |P=0.259N     P=0.475N     P=0.590      P=0.356N     | 
|COCH-ARM / FISHERS |     P=0.400      P=0.500N     P=0.309      P=0.753N    |P=0.457N     P=0.495N     P=0.508      P=0.495N     | 
|ORDER RESTRICTED   |     P=0.248      (e)          (e)          (e)         |P=0.345N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    4/50 (8%)    6/50 (12%)  |0/49 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.19      3/39.04      4/42.39      6/39.97     |0/44.22      1/44.54      1/45.34      1/40.84      | 
|POLY-3 PERCENT (g) |     4.4%         7.7%         9.4%         15.0%       |0.0%         2.3%         2.2%         2.5%         | 
|TERMINAL (d)       |     1/29 (3%)    2/19 (11%)   1/21 (5%)    3/16 (19%)  |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     691          537          546          667         |---          506          563          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.036 *    P=0.331      P=0.263      P=0.039 *   |P=0.367      P=0.500      P=0.513      P=0.468      | 
|POLY 3             |     P=0.062      P=0.434      P=0.308      P=0.096     |P=0.350      P=0.501      P=0.505      P=0.484      | 
|POLY 1.5           |     P=0.070      P=0.463      P=0.320      P=0.111     |P=0.365      P=0.503      P=0.504      P=0.492      | 
|POLY 6             |     P=0.051      P=0.390      P=0.294      P=0.077     |P=0.331      P=0.498      P=0.505      P=0.473      | 
|LOGISTIC REGRESSION|     P=0.072      P=0.487      P=0.380      P=0.073     |P=0.536      P=0.530      P=0.556      P=0.506      | 
|COCH-ARM / FISHERS |     P=0.081      P=0.500      P=0.339      P=0.134     |P=0.388      P=0.505      P=0.505      P=0.505      | 
|ORDER RESTRICTED   |     P=0.062      (e)          (e)          (e)         |P=0.314      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |2/49 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.11      0/38.44      2/41.80      0/39.41     |2/45.28      1/43.89      2/45.66      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.8%         0.0%        |4.4%         2.3%         4.4%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    1/21 (5%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     712          ---          593          ---         |481          726          401          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.599N     P=0.606N     P=0.421      P=0.606N    |P=0.241N     P=0.510N     P=0.680      P=0.261N     | 
|POLY 3             |     P=0.532N     P=0.532N     P=0.473      P=0.527N    |P=0.223N     P=0.511N     P=0.691N     P=0.262N     | 
|POLY 1.5           |     P=0.525N     P=0.518N     P=0.484      P=0.515N    |P=0.212N     P=0.503N     P=0.689N     P=0.250N     | 
|POLY 6             |     P=0.544N     P=0.552N     P=0.460      P=0.544N    |P=0.237N     P=0.522N     P=0.693      P=0.279N     | 
|LOGISTIC REGRESSION|     P=0.521N     P=0.568N     P=0.521      P=0.555N    |P=0.095N     P=0.467N     P=0.643N     P=0.108N     | 
|COCH-ARM / FISHERS |     P=0.518N     P=0.500N     P=0.500      P=0.500N    |P=0.196N     P=0.492N     P=0.684N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.323N     (e)          (e)          (e)         |P=0.175N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    4/50 (8%)    1/50 (2%)   |1/49 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.31      2/38.89      4/42.29      1/39.48     |1/44.91      1/44.30      2/45.41      1/40.72      | 
|POLY-3 PERCENT (g) |     4.4%         5.1%         9.5%         2.5%        |2.2%         2.3%         4.4%         2.5%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    1/21 (5%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     670          667          558          712         |495          606          565          714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.544N     P=0.496      P=0.253      P=0.655N    |P=0.547      P=0.758      P=0.493      P=0.727      | 
|POLY 3             |     P=0.495N     P=0.638      P=0.305      P=0.548N    |P=0.543      P=0.758      P=0.504      P=0.738      | 
|POLY 1.5           |     P=0.472N     P=0.663      P=0.318      P=0.527N    |P=0.564      P=0.760N     P=0.505      P=0.749      | 
|POLY 6             |     P=0.531N     P=0.600      P=0.290      P=0.578N    |P=0.516      P=0.753      P=0.503      P=0.724      | 
|LOGISTIC REGRESSION|     P=0.444N     P=0.699      P=0.381      P=0.551N    |P=0.524N     P=0.750N     P=0.558      P=0.690N     | 
|COCH-ARM / FISHERS |     P=0.445N     P=0.691N     P=0.339      P=0.500N    |P=0.596      P=0.747N     P=0.508      P=0.747N     | 
|ORDER RESTRICTED   |     P=0.350N     (e)          (e)          (e)         |P=0.574      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |2/49 (4%)    1/50 (2%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     3/46.45      0/38.44      3/42.53      0/39.41     |2/44.91      1/44.10      0/44.80      3/42.63      | 
|POLY-3 PERCENT (g) |     6.5%         0.0%         7.1%         0.0%        |4.5%         2.3%         0.0%         7.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |1/36 (3%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     476          ---          509          ---         |495          670          ---          451          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.276N     P=0.163N     P=0.605      P=0.159N    |P=0.308      P=0.526N     P=0.255N     P=0.458      | 
|POLY 3             |     P=0.238N     P=0.156N     P=0.621      P=0.151N    |P=0.332      P=0.506N     P=0.238N     P=0.476      | 
|POLY 1.5           |     P=0.233N     P=0.139N     P=0.638      P=0.136N    |P=0.336      P=0.501N     P=0.236N     P=0.490      | 
|POLY 6             |     P=0.249N     P=0.185N     P=0.600      P=0.174N    |P=0.326      P=0.514N     P=0.240N     P=0.457      | 
|LOGISTIC REGRESSION|     P=0.164N     P=0.018N*    P=0.383N     P=0.019N*   |P=0.569      P=0.471N     P=0.204N     P=0.629N     | 
|COCH-ARM / FISHERS |     P=0.232N     P=0.121N     P=0.661N     P=0.121N    |P=0.342      P=0.492N     P=0.242N     P=0.510      | 
|ORDER RESTRICTED   |     P=0.078N     (e)          (e)          (e)         |P=0.168      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    2/49 (4%)    1/50 (2%)   |0/49 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/45.47      3/39.57      2/40.95      1/39.51     |0/44.22      2/44.26      0/44.80      2/40.84      | 
|POLY-3 PERCENT (g) |     4.4%         7.6%         4.9%         2.5%        |0.0%         4.5%         0.0%         4.9%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     670          605          633          705         |---          656          ---          694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.344N     P=0.355      P=0.629      P=0.616N    |P=0.191      P=0.228      (e)          P=0.180      | 
|POLY 3             |     P=0.327N     P=0.437      P=0.656      P=0.549N    |P=0.227      P=0.237      (e)          P=0.220      | 
|POLY 1.5           |     P=0.307N     P=0.464      P=0.668      P=0.527N    |P=0.236      P=0.239      (e)          P=0.228      | 
|POLY 6             |     P=0.358N     P=0.398      P=0.640      P=0.580N    |P=0.215      P=0.234      (e)          P=0.209      | 
|LOGISTIC REGRESSION|     P=0.260N     P=0.642      P=0.676N     P=0.500N    |P=0.245      P=0.246      (e)          P=0.217      | 
|COCH-ARM / FISHERS |     P=0.283N     P=0.500      P=0.684      P=0.500N    |P=0.251      P=0.253      (e)          P=0.253      | 
|ORDER RESTRICTED   |     P=0.374N     (e)          (e)          (e)         |P=0.104      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/49 (6%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      1/38.66      3/41.32      0/39.41     |0/44.22      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         7.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          670          556          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.577      P=0.392      P=0.101      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.562      P=0.470      P=0.104      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.592      P=0.483      P=0.108      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.513      P=0.450      P=0.099      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.611N     P=0.518      P=0.144      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.626      P=0.500      P=0.117      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.204      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/49 (2%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      1/38.45      1/40.90      2/39.74     |0/44.22      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         2.4%         5.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          726          633          667         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123      P=0.419      P=0.476      P=0.164     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.143      P=0.469      P=0.481      P=0.210     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.153      P=0.482      P=0.487      P=0.222     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.130      P=0.448      P=0.474      P=0.195     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.158      P=0.404      P=0.562      P=0.224     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.165      P=0.500      P=0.495      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.099      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Artery                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     2/45.42      2/38.87      1/41.34      2/39.56     |                                                    | 
|POLY-3 PERCENT (g) |     4.4%         5.2%         2.4%         5.1%        |                                                    | 
|TERMINAL (d)       |     1/29 (3%)    1/19 (5%)    1/21 (5%)    1/16 (6%)   |                                                    | 
|FIRST INCIDENCE    |     621          605          729 (T)      691         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.505      P=0.592      P=0.590N     P=0.531     |                                                    | 
|POLY 3             |     P=0.587N     P=0.637      P=0.533N     P=0.643     |                                                    | 
|POLY 1.5           |     P=0.575N     P=0.662      P=0.519N     P=0.666     |                                                    | 
|POLY 6             |     P=0.573      P=0.597      P=0.550N     P=0.610     |                                                    | 
|LOGISTIC REGRESSION|     P=0.586N     P=0.676N     P=0.509N     P=0.672     |                                                    | 
|COCH-ARM / FISHERS |     P=0.561N     P=0.691N     P=0.500N     P=0.691N    |                                                    | 
|ORDER RESTRICTED   |     P=0.625      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  9/50 (18%)   15/50 (30%)  11/50 (22%) |                                                    | 
|POLY-3 RATE (b)    |     11/45.57     9/39.47      15/42.43     11/40.40    |                                                    | 
|POLY-3 PERCENT (g) |     24.1%        22.8%        35.4%        27.2%       |                                                    | 
|TERMINAL (d)       |     8/29 (28%)   5/19 (26%)   9/21 (43%)   3/16 (19%)  |                                                    | 
|FIRST INCIDENCE    |     621          605          633          636         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.101      P=0.414      P=0.075      P=0.151     |                                                    | 
|POLY 3             |     P=0.296      P=0.544N     P=0.177      P=0.468     |                                                    | 
|POLY 1.5           |     P=0.335      P=0.481N     P=0.204      P=0.524     |                                                    | 
|POLY 6             |     P=0.245      P=0.570      P=0.149      P=0.392     |                                                    | 
|LOGISTIC REGRESSION|     P=0.234      P=0.528      P=0.132      P=0.328     |                                                    | 
|COCH-ARM / FISHERS |     P=0.383      P=0.402N     P=0.247      P=0.595N    |                                                    | 
|ORDER RESTRICTED   |     P=0.319      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    2/50 (4%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     5/45.70      4/41.08      2/41.72      2/40.30     |                                                    | 
|POLY-3 PERCENT (g) |     10.9%        9.7%         4.8%         5.0%        |                                                    | 
|TERMINAL (d)       |     2/29 (7%)    0/19 (0%)    1/21 (5%)    0/16 (0%)   |                                                    | 
|FIRST INCIDENCE    |     611          421          621          593         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.200N     P=0.613      P=0.320N     P=0.388N    |                                                    | 
|POLY 3             |     P=0.152N     P=0.567N     P=0.254N     P=0.270N    |                                                    | 
|POLY 1.5           |     P=0.142N     P=0.536N     P=0.238N     P=0.246N    |                                                    | 
|POLY 6             |     P=0.166N     P=0.616N     P=0.275N     P=0.307N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.077N     P=0.168N     P=0.211N     P=0.156N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.129N     P=0.500N     P=0.218N     P=0.218N    |                                                    | 
|ORDER RESTRICTED   |     P=0.229N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   4/50 (8%)    6/50 (12%)   11/50 (22%) |11/49 (22%)  6/50 (12%)   4/50 (8%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     8/46.03      4/39.62      6/42.00      11/42.27    |11/44.25     6/43.87      4/44.85      5/41.07      | 
|POLY-3 PERCENT (g) |     17.4%        10.1%        14.3%        26.0%       |24.9%        13.7%        8.9%         12.2%        | 
|TERMINAL (d)       |     4/29 (14%)   1/19 (5%)    4/21 (19%)   2/16 (13%)  |10/36 (28%)  6/30 (20%)   3/32 (9%)    4/25 (16%)   | 
|FIRST INCIDENCE    |     576          590          558          465         |722          730 (T)      718          611          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037 *    P=0.379N     P=0.588N     P=0.094     |P=0.179N     P=0.247N     P=0.073N     P=0.262N     | 
|POLY 3             |     P=0.092      P=0.257N     P=0.458N     P=0.232     |P=0.075N     P=0.143N     P=0.040N*    P=0.109N     | 
|POLY 1.5           |     P=0.097      P=0.220N     P=0.428N     P=0.264     |P=0.070N     P=0.138N     P=0.040N*    P=0.095N     | 
|POLY 6             |     P=0.084      P=0.315N     P=0.498N     P=0.191     |P=0.082N     P=0.153N     P=0.040N*    P=0.130N     | 
|LOGISTIC REGRESSION|     P=0.108      P=0.154N     P=0.412N     P=0.415     |P=0.124N     P=0.199N     P=0.053N     P=0.162N     | 
|COCH-ARM / FISHERS |     P=0.101      P=0.178N     P=0.387N     P=0.306     |P=0.063N     P=0.133N     P=0.041N*    P=0.079N     | 
|ORDER RESTRICTED   |     P=0.093      (e)          (e)          (e)         |P=0.044N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue: Epithelium                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/1 (100%)   1/1 (100%)   1/3 (33%)    0/0 (0%)    |0/1 (0%)     3/3 (100%)   0/0 (0%)     1/1 (100%)   | 
|POLY-3 RATE (b)    |     1/1.00       1/1.00       1/2.92       0/0.00      |0/1.00       3/3.00       0/0.00       1/1.00       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       34.3%        0.0%        |0.0%         100.0%       0.0%         100.0%       | 
|TERMINAL (d)       |     1/1 (100%)   1/1 (100%)   1/2 (50%)    0/0 (0%)    |0/1 (0%)     2/2 (100%)   0/0 (0%)     1/1 (100%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          703          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.556N     (e)          P=0.638N     (e)         |P=0.514      P=0.152      (e)          P=0.500      | 
|POLY 3             |     (e)          (e)          P=0.509N     (e)         |(e)          P=0.250N     (e)          P=1.000      | 
|POLY 1.5           |     (e)          (e)          P=0.504N     (e)         |(e)          P=0.250N     (e)          P=1.000      | 
|POLY 6             |     (e)          (e)          P=0.517N     (e)         |(e)          P=0.250N     (e)          P=1.000      | 
|LOGISTIC REGRESSION|     P=0.556N     (e)          P=0.638N     (e)         |(e)          (e)          (e)          P=0.250      | 
|COCH-ARM / FISHERS |     P=0.338N     (e)          P=0.500N     (e)         |P=0.371      P=0.250      (e)          P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder: Transitional Epithelium                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/49 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      0/41.34      1/39.71     |1/44.49      0/43.87      2/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.5%        |2.3%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    2/32 (6%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          647         |656          ---          730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.180      (e)          (e)          P=0.454     |P=0.528N     P=0.505N     P=0.475      P=0.531N     | 
|POLY 3             |     P=0.180      (e)          (e)          P=0.475     |P=0.486N     P=0.503N     P=0.502      P=0.518N     | 
|POLY 1.5           |     P=0.184      (e)          (e)          P=0.486     |P=0.475N     P=0.500N     P=0.504      P=0.509N     | 
|POLY 6             |     P=0.175      (e)          (e)          P=0.459     |P=0.502N     P=0.508N     P=0.499      P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.196      (e)          (e)          P=0.557     |P=0.476N     P=0.487N     P=0.506      P=0.471N     | 
|COCH-ARM / FISHERS |     P=0.188      (e)          (e)          P=0.500     |P=0.457N     P=0.495N     P=0.508      P=0.495N     | 
|ORDER RESTRICTED   |     P=0.101      (e)          (e)          (e)         |P=0.342N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/49 (2%)    1/50 (2%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.29      1/44.30      1/44.96      3/40.82      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         2.3%         2.2%         7.4%         | 
|TERMINAL (d)       |                                                        |0/36 (0%)    0/30 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |                                                        |712          606          689          696          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.112      P=0.745      P=0.751      P=0.202      | 
|POLY 3             |                                                        |P=0.148      P=0.761N     P=0.757N     P=0.276      | 
|POLY 1.5           |                                                        |P=0.155      P=0.758N     P=0.757N     P=0.291      | 
|POLY 6             |                                                        |P=0.139      P=0.757      P=0.758N     P=0.258      | 
|LOGISTIC REGRESSION|                                                        |P=0.161      P=0.750N     P=0.758N     P=0.255      | 
|COCH-ARM / FISHERS |                                                        |P=0.167      P=0.747N     P=0.747N     P=0.316      | 
|ORDER RESTRICTED   |                                                        |P=0.158      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                STODDARD SOLVENT (TYPE IIC)             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/49 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/44.22      0/43.87      0/44.80      2/40.93      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         0.0%         4.9%         | 
|TERMINAL (d)       |                                                        |0/36 (0%)    0/30 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          ---          656          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.032 *    (e)          (e)          P=0.185      | 
|POLY 3             |                                                        |P=0.043 *    (e)          (e)          P=0.220      | 
|POLY 1.5           |                                                        |P=0.044 *    (e)          (e)          P=0.229      | 
|POLY 6             |                                                        |P=0.042 *    (e)          (e)          P=0.209      | 
|LOGISTIC REGRESSION|                                                        |P=0.044 *    (e)          (e)          P=0.230      | 
|COCH-ARM / FISHERS |                                                        |P=0.047 *    (e)          (e)          P=0.253      | 
|ORDER RESTRICTED   |                                                        |P=0.024 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/49 (2%)    5/50 (10%)   2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.22      5/44.53      2/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         11.2%        4.5%         0.0%         | 
|TERMINAL (d)       |                                                        |1/36 (3%)    2/30 (7%)    2/32 (6%)    0/25 (0%)    | 
|FIRST INCIDENCE    |                                                        |730 (T)      606          730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.239N     P=0.084      P=0.459      P=0.573N     | 
|POLY 3             |                                                        |P=0.194N     P=0.102      P=0.505      P=0.517N     | 
|POLY 1.5           |                                                        |P=0.179N     P=0.104      P=0.505      P=0.508N     | 
|POLY 6             |                                                        |P=0.216N     P=0.099      P=0.503      P=0.528N     | 
|LOGISTIC REGRESSION|                                                        |P=0.179N     P=0.106      P=0.459      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.160N     P=0.107      P=0.508      P=0.495N     | 
|ORDER RESTRICTED   |                                                        |P=0.105N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
                                                                                                                                   
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.