National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3982

TDMS Study 96001-05 Pathology Tables

NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30

                                                           FINAL/RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  64742-88-7

       Lock Date:  09/24/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12           19           15           23                                     
    Natural Death                                      2            1            3            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           30           32           25                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)         (50)                                   
      Periesophageal Tissue, Necrosis, Fatty           1 [4.0]                                                                      
   Intestine Small, Jejunum                           (49)         (49)         (47)         (48)                                   
      Ulcer                                                                      1 [4.0]                                            
   Liver                                              (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 [2.0]      2 [2.5]      2 [1.5]      2 [2.5]                               
      Basophilic Focus                                 2 [2.0]      3 [1.5]      1 [1.5]      1 [1.0]                               
      Clear Cell Focus                                 7 [2.0]      7 [2.4]      6 [2.0]      2 [1.0]                               
      Clear Cell Focus, Multiple                       2 [2.5]                   1 [1.0]      1 [3.0]                               
      Degeneration, Cystic                                                       1 [2.0]                                            
      Hematopoietic Cell Proliferation                                           1 [4.0]                                            
      Hemorrhage                                       1 [4.0]                                                                      
      Hepatodiaphragmatic Nodule                       5 [4.0]      9 [4.0]      5 [4.0]      6 [3.5]                               
      Necrosis                                                                   2 [3.0]                                            
      Thrombosis                                       1 [4.0]                                                                      
      Vacuolization Cytoplasmic                        2 [3.5]      5 [3.2]      6 [2.8]      1 [1.0]                               
      Bile Duct, Cyst                                  1                                                                            
      Hepatocyte, Regeneration                                                                3 [4.0]                               
      Serosa, Fibrosis                                 1 [2.0]                                1 [3.0]                               
   Mesentery                                          (11)         (15)         (23)         (14)                                   
      Necrosis                                        11 [2.9]     15 [2.9]     23 [3.2]     13 [2.9]                               
   Pancreas                                           (49)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                  2 [2.0]      1 [3.0]      1 [4.0]                                            
      Artery, Thrombosis                                                                      1 [4.0]                               
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                            1 [3.0]                                                                      
      Ulcer                                                         2 [4.0]                   2 [3.0]                               
   Stomach, Glandular                                 (49)         (50)         (50)         (50)                                   
      Necrosis                                         1 [1.0]                                                                      
   Tongue                                             (1)          (3)                       (1)                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Epithelium, Hyperkeratosis                       1 [2.0]                                                                      
      Epithelium, Hyperplasia                                       3 [3.7]                   1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   1 [2.0]                   1 [2.0]      2 [1.5]                               
      Atrium, Thrombosis                               2 [3.5]      1 [3.0]      2 [3.5]      1 [3.0]                               
      Myocardium, Degeneration                                                                1 [3.0]                               
      Ventricle, Hypertrophy                                                     1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 [4.0]                                                                      
      Necrosis                                         1 [4.0]      1 [1.0]                   2 [3.5]                               
      Vacuolization Cytoplasmic                        9 [2.1]      4 [1.8]     15 [2.3]     12 [2.3]                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 [3.0]                                                                      
      Degeneration, Cystic                                                                    1 [4.0]                               
      Hyperplasia                                      4 [3.5]      2 [3.5]      7 [2.3]      4 [1.8]                               
   Parathyroid Gland                                  (49)         (49)         (49)         (50)                                   
      Hyperplasia                                                   1 [2.0]                                                         
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Mineralization                                                             1 [4.0]                                            
      Pars Distalis, Angiectasis                       2 [3.5]                   2 [2.5]      2 [2.5]                               
      Pars Distalis, Cyst                              5            3            3            3                                     
      Pars Distalis, Hemorrhage                                                               1 [4.0]                               
      Pars Distalis, Hyperplasia                       9 [2.9]      9 [2.9]      8 [3.0]      8 [3.1]                               
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                             11 [1.6]      6 [2.3]      4 [2.3]      5 [2.6]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             1                                                                            
      Hyperplasia                                      2 [2.0]      3 [3.0]      3 [2.0]      1 [2.0]                               
      Inflammation, Chronic                                         1 [4.0]      1 [2.0]      1 [4.0]                               
      Metaplasia, Squamous                                          1 [4.0]                                                         
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             8            9            8            5                                     
   Uterus                                             (49)         (50)         (50)         (50)                                   
      Atrophy                                                       1 [4.0]                                                         
      Decidual Reaction                                                                       1 [4.0]                               
      Degeneration                                                                            1 [4.0]                               
      Hemorrhage                                       1 [4.0]      1 [4.0]      1 [4.0]      3 [4.0]                               
      Necrosis                                                                                2 [4.0]                               
      Prolapse                                                                                1                                     
      Capillary, Myometrium, Hyperplasia                                                      1 [4.0]                               
      Endometrium, Hyperplasia                         1 [1.0]                   1 [3.0]      1 [3.0]                               
      Endometrium, Hyperplasia, Cystic                 1 [1.0]      5 [3.0]      2 [2.5]                                            
      Endometrium, Inflammation, Suppurative                                                  1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia, Reticulum Cell                                   1 [4.0]                                                         
   Lymph Node                                         (5)          (5)          (5)          (4)                                    
      Pancreatic, Infiltration Cellular, Histiocyte                 1 [4.0]                                                         
   Lymph Node, Bronchial                              (12)         (7)          (8)          (11)                                   
      Infiltration Cellular, Histiocyte                                                       1 [4.0]                               
      Pigmentation                                                               2 [2.5]                                            
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
      Necrosis                                                                                1 [4.0]                               
   Lymph Node, Mediastinal                            (45)         (39)         (42)         (45)                                   
      Angiectasis                                                   1 [4.0]                                                         
      Hemorrhage                                                                              1 [3.0]                               
      Hyperplasia, Lymphoid                                                      1 [2.0]                                            
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Accessory Spleen                                 1                         2                                                  
      Fibrosis                                                      1 [2.0]      1 [2.0]      1 [3.0]                               
      Hematopoietic Cell Proliferation                 2 [4.0]      1 [4.0]      2 [4.0]                                            
      Hemorrhage                                       1 [4.0]      1 [4.0]      2 [4.0]      1 [4.0]                               
      Necrosis                                         2 [4.0]      1 [4.0]                   3 [3.7]                               
      Thrombosis                                                                              1 [4.0]                               
   Thymus                                             (47)         (47)         (46)         (48)                                   
      Cyst                                                          1                                                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Galactocele                                      1 [1.0]                   2 [2.0]      2 [2.5]                               
      Inflammation, Chronic                            1 [3.0]                                                                      
      Epithelium, Hyperplasia                                                                 1 [3.0]                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     1 [4.0]      1 [4.0]      1 [4.0]                               
      Hyperkeratosis                                   1 [4.0]                   1 [4.0]                                            
      Inflammation, Chronic                                                                   1 [1.0]                               
      Inflammation, Granulomatous                                                1 [4.0]                                            
      Ulcer                                                                      1 [4.0]      1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Compression                                      9 [2.8]      8 [2.8]      3 [3.0]      6 [2.8]                               
      Gliosis                                                                    1 [4.0]                                            
      Hemorrhage                                       4 [2.8]      3 [3.0]      6 [3.0]      1 [3.0]                               
      Necrosis                                                                   1 [4.0]                                            
      Cerebellum, Developmental Malformation                                     1 [2.0]                                            
      Cerebellum, Gliosis                                                        1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (50)         (50)         (49)                                   
      Foreign Body                                     2 [4.0]      1 [4.0]      2 [3.0]      1 [4.0]                               
      Inflammation, Chronic                            3 [2.0]      1 [2.0]                                                         
      Epiglottis, Metaplasia, Squamous                 1 [4.0]                                1 [2.0]                               
      Respiratory Epithelium, Hyperplasia                           1 [1.0]                                                         
   Lung                                               (49)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 [1.0]      2 [1.5]      1 [1.0]      1 [2.0]                               
      Necrosis                                                                                1 [4.0]                               
      Alveolar Epithelium, Hyperplasia                 3 [1.0]      1 [1.0]      1 [2.0]      3 [1.0]                               
      Alveolar Epithelium, Metaplasia, Squamous                     1 [1.0]                                                         
      Alveolus, Infiltration Cellular, Histiocyte     22 [1.3]     14 [1.4]     13 [1.3]     15 [1.3]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolus, Proteinosis                                                                   1 [1.0]                               
      Bronchiole, Hyperplasia, Focal                                                          1 [2.0]                               
      Interstitium, Fibrosis                           2 [2.0]      2 [1.5]      2 [1.5]      2 [1.5]                               
      Vein, Fibrosis                                                1 [4.0]                                                         
   Nose                                               (49)         (50)         (49)         (50)                                   
      Foreign Body                                     2 [1.0]      2 [3.0]                                                         
      Inflammation, Suppurative                        1 [3.0]      5 [1.8]      3 [2.0]                                            
      Goblet Cell, Hyperplasia                         1 [2.0]      3 [2.3]      3 [2.3]      1 [2.0]                               
      Nasolacrimal Duct, Inflammation, Suppurative     2 [2.5]                   1 [3.0]      1 [3.0]                               
      Olfactory Epithelium, Degeneration, Hyaline     12 [1.5]     18 [1.2]     15 [1.3]     28 [1.5]                               
      Olfactory Epithelium, Hyperplasia                             1 [2.0]                                                         
      Respiratory Epithelium, Metaplasia, Squamous                  2 [2.0]                                                         
   Pleura                                             (48)         (50)         (50)         (50)                                   
      Fibrosis                                        18 [1.5]      6 [1.3]      9 [1.6]     12 [1.3]                               
      Inflammation, Chronic                           21 [1.5]     20 [1.4]     13 [1.6]      5 [1.6]                               
      Mesothelium, Hyperplasia                                      1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (50)         (50)         (49)                                   
      Atrophy                                                       1 [4.0]                                                         
      Anterior Chamber, Inflammation, Suppurative                   1 [1.0]                                                         
      Cornea, Hyperplasia                              1 [2.0]                                                                      
      Lens, Cataract                                   3 [3.3]      2 [4.0]      1 [3.0]      4 [3.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Cyst                                                          2                         1                                     
      Fibrosis                                                      1 [4.0]                                                         
      Infarct                                                       1 [2.0]      1 [3.0]                                            
      Nephropathy, Chronic                            42 [1.7]     44 [1.8]     46 [2.0]     44 [1.8]                               
      Cortex, Infarct                                  1 [3.0]                                                                      
      Cortex, Inflammation, Suppurative                                                       1 [1.0]                               
      Cortex, Renal Tubule, Accumulation, Hyaline                                                                                   
        Droplet                                                                               1 [3.0]                               
      Cortex, Renal Tubule, Hyperplasia                                          1 [1.0]                                            
      Cortex, Renal Tubule, Inflammation               1 [2.0]                                                                      
      Papilla, Mineralization                          3 [1.3]      1 [2.0]      1 [1.0]                                            
      Pelvis, Transitional Epithelium, Hyperplasia     4 [1.3]      3 [1.7]      7 [1.4]      3 [1.7]                               
      Pelvis, Transitional Epithelium,                                                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
        Mineralization                                25 [1.2]     23 [1.3]     27 [1.1]     27 [1.2]                               
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 [3.0]                                                         
      Muscularis, Hyperplasia                                                                 1 [2.0]                               
      Muscularis, Infiltration Cellular, Histiocyte                 1 [1.0]                                                         
      Transitional Epithelium, Hyperplasia             1 [3.0]                   2 [1.0]                                            
      Transitional Epithelium, Ulcer                   1 [4.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      138          550          1100                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           27           21           27                                     
    Natural Death                                      3            4            8            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           19           21           16                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 [3.0]                               
   Intestine Large, Cecum                             (49)         (49)         (48)         (48)                                   
      Atrophy                                                                                 1 [3.0]                               
      Necrosis                                                      1 [4.0]                                                         
      Epithelium, Cyst                                              1                                                               
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 [2.0]                                            
      Basophilic Focus                                 1 [2.0]                                                                      
      Clear Cell Focus                                 6 [1.5]      4 [1.5]      3 [3.0]      3 [2.5]                               
      Eosinophilic Focus                                                                      1 [3.0]                               
      Hemorrhage                                       1 [3.0]                                                                      
      Hepatodiaphragmatic Nodule                       7 [4.0]      3 [4.0]      5 [4.0]      3 [3.7]                               
      Inflammation, Granulomatous                      1 [2.0]      1 [2.0]                   1 [2.0]                               
      Necrosis                                         1 [3.0]                                1 [4.0]                               
      Thrombosis                                                                              1 [3.0]                               
      Vacuolization Cytoplasmic                        3 [3.3]      3 [2.3]      1 [4.0]      2 [3.0]                               
      Bile Duct, Hyperplasia                                                     3 [3.0]      2 [3.0]                               
      Hepatocyte, Regeneration                                                                1 [4.0]                               
      Periportal, Pigmentation                         1 [4.0]                   2 [4.0]                                            
   Mesentery                                          (7)          (11)         (11)         (13)                                   
      Necrosis                                         7 [2.6]     11 [2.8]     11 [3.0]     12 [2.6]                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                  2 [3.0]      2 [3.0]      1 [3.0]      2 [3.5]                               
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Hyperplasia, Squamous                            1 [3.0]                   1 [3.0]                                            
      Ulcer                                            2 [4.0]      3 [4.0]      2 [4.0]      1 [4.0]                               
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
      Erosion                                                       1 [4.0]      3 [2.7]                                            
      Hyperplasia                                                                1 [2.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      138          550          1100                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mineralization                                                1 [4.0]                                                         
      Ulcer                                                         1 [3.0]      1 [3.0]      2 [3.5]                               
   Tongue                                             (1)          (1)          (3)                                                 
      Epithelium, Hyperkeratosis                                                 1 [3.0]                                            
      Epithelium, Hyperplasia                          1 [4.0]      1 [3.0]      1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Mineralization                                                1 [4.0]                                                         
      Pulmonary Artery, Thrombosis                                                            1 [4.0]                               
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  13 [1.5]      4 [2.3]      5 [2.0]      9 [2.2]                               
      Artery, Mineralization                                        1 [4.0]                                                         
      Atrium, Thrombosis                               1 [2.0]                   1 [4.0]      5 [3.0]                               
      Myocardium, Thrombosis                                                                  1 [4.0]                               
      Ventricle, Thrombosis                                                                   1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Mineralization                                                             1 [3.0]                                            
      Necrosis                                         1 [1.0]      1 [2.0]      1 [3.0]                                            
      Vacuolization Cytoplasmic                       15 [1.6]      5 [2.6]     14 [2.1]     10 [2.2]                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     12 [2.5]     14 [2.6]     23 [2.6]     15 [2.2]                               
      Mineralization                                                                          1 [4.0]                               
      Necrosis                                                                                2 [4.0]                               
      Thrombosis                                                                 1 [4.0]                                            
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 [3.0]      1 [4.0]                   1 [3.0]                               
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Cyst                              1                         1            1                                     
      Pars Distalis, Hemorrhage                                     1 [2.0]      1 [4.0]      3 [4.0]                               
      Pars Distalis, Hyperplasia                       4 [3.0]      5 [3.0]      6 [2.7]      5 [2.8]                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                              8 [2.1]      4 [2.8]      6 [2.0]     11 [1.8]                               
      Follicular Cell, Hyperplasia                                  1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      138          550          1100                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (14)         (41)         (41)         (32)                                   
      Inflammation, Granulomatous                                                             1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                                            1 [4.0]                                            
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Cyst                                             1            1            1            1                                     
      Hyperplasia                                      1 [3.0]      1 [4.0]                   2 [2.5]                               
      Inflammation, Suppurative                                                  4 [3.0]                                            
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 [2.0]      1 [3.0]                   3 [3.0]                               
      Inflammation, Suppurative                       10 [2.4]     10 [2.0]     14 [1.9]     12 [2.6]                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Dilatation                                                                 1 [4.0]      1 [4.0]                               
      Hyperplasia                                                                             1 [4.0]                               
   Testes                                             (50)         (50)         (50)         (50)                                   
      Artery, Inflammation, Chronic Active             2 [2.5]      2 [2.5]      1 [3.0]      2 [2.5]                               
      Germinal Epithelium, Atrophy                    11 [3.9]      9 [3.6]     15 [3.5]     11 [3.8]                               
      Interstitial Cell, Hyperplasia                   5 [3.0]      4 [2.3]      2 [3.5]      2 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Thrombosis                                                                              1 [2.0]                               
      Myeloid Cell, Hyperplasia                                                  1 [4.0]                                            
   Lymph Node                                         (7)          (16)         (11)         (17)                                   
      Hyperplasia, Lymphoid                                                                   1 [3.0]                               
      Deep Cervical, Angiectasis                                                              1 [3.0]                               
      Deep Cervical, Ectasia                                        1 [4.0]                                                         
      Pancreatic, Angiectasis                          1 [4.0]                                                                      
      Pancreatic, Ectasia                              1 [4.0]                   1 [4.0]                                            
      Pancreatic, Infiltration Cellular, Histiocyte                 1 [4.0]                                                         
      Pancreatic, Pigmentation                                      1 [4.0]                   1 [4.0]                               
      Thoracic, Ectasia                                                                       1 [4.0]                               
   Lymph Node, Bronchial                              (15)         (12)         (16)         (13)                                   
      Fibrosis                                         1 [2.0]                                                                      
      Hematopoietic Cell Proliferation                 1 [3.0]                                                                      
      Hyperplasia, Lymphoid                            1 [3.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      138          550          1100                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infiltration Cellular, Histiocyte                1 [2.0]      1 [3.0]                                                         
      Pigmentation                                     1 [2.0]      1 [3.0]                                                         
   Lymph Node, Mandibular                             (2)                                                                           
      Hematopoietic Cell Proliferation                 1 [4.0]                                                                      
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                         1 [4.0]                                                         
      Necrosis                                                                   2 [3.5]                                            
   Lymph Node, Mediastinal                            (42)         (44)         (43)         (40)                                   
      Angiectasis                                                                2 [3.0]                                            
      Hyperplasia, Lymphoid                            1 [3.0]      1 [3.0]      1 [3.0]                                            
      Infiltration Cellular                                                      1 [3.0]                                            
      Infiltration Cellular, Histiocyte                                                       1 [4.0]                               
      Pigmentation                                                               1 [2.0]                                            
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                 1                         3            1                                     
      Fibrosis                                         2 [3.5]      3 [3.7]      4 [3.3]      6 [2.8]                               
      Hematopoietic Cell Proliferation                 1 [4.0]                   2 [3.5]                                            
      Hemorrhage                                       2 [3.0]      2 [4.0]      4 [3.5]      1 [4.0]                               
      Necrosis                                         3 [3.7]                   3 [4.0]                                            
      Thrombosis                                                                 1 [4.0]                                            
   Thymus                                             (49)         (49)         (47)         (50)                                   
      Cyst                                                                                    1                                     
      Thrombosis                                                                 1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Galactocele                                      3 [4.0]      2 [3.5]      3 [4.0]      2 [2.5]                               
      Hyperplasia                                                   1 [4.0]                                                         
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        5 [4.0]      2 [4.0]      2 [2.5]      3 [4.0]                               
      Hyperkeratosis                                   1 [4.0]                   1 [3.0]      2 [3.5]                               
      Hyperplasia                                                                             1 [3.0]                               
      Inflammation, Chronic                                                      2 [3.0]                                            
      Inflammation, Granulomatous                                                1 [4.0]                                            
      Ulcer                                                                                   1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     1 [3.0]      1 [3.0]      1 [3.0]      1 [3.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      138          550          1100                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
      Rib, Cartilage, Degeneration                     1 [3.0]                                                                      
      Turbinate, Cartilage, Hyperplasia                                                       1 [4.0]                               
   Skeletal Muscle                                    (1)          (1)          (1)          (1)                                    
      Hemorrhage                                       1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                     13 [3.1]     15 [3.3]     10 [3.3]      9 [3.3]                               
      Hemorrhage                                       4 [3.3]      4 [3.3]      5 [3.6]      3 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 [4.0]      2 [4.0]      2 [4.0]      3 [3.7]                               
      Inflammation, Chronic                                                      2 [3.0]                                            
      Inflammation, Suppurative                                     2 [3.0]                   2 [2.5]                               
      Epiglottis, Metaplasia, Squamous                              1 [2.0]                                                         
   Lung                                               (50)         (50)         (50)         (49)                                   
      Foreign Body                                                                            1 [1.0]                               
      Hemorrhage                                       5 [2.0]      5 [2.0]      6 [3.2]      4 [2.3]                               
      Inflammation, Suppurative                                                               2 [3.0]                               
      Alveolar Epithelium, Hyperplasia                10 [1.5]      3 [2.3]      6 [2.8]      7 [2.6]                               
      Alveolar Epithelium, Metaplasia, Squamous                                  2 [2.0]                                            
      Alveolus, Foreign Body                                                                  1 [2.0]                               
      Alveolus, Infiltration Cellular, Histiocyte     13 [1.4]     11 [1.8]      7 [1.7]      5 [1.4]                               
      Alveolus, Mineralization                                      1 [4.0]                                                         
      Alveolus, Proteinosis                                         1 [2.0]                                                         
      Interstitium, Fibrosis                           1 [4.0]      5 [1.4]      2 [2.0]      1 [2.0]                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     2 [3.0]      3 [3.0]      1 [3.0]      2 [2.5]                               
      Inflammation, Suppurative                        4 [2.8]      4 [2.5]      2 [1.5]      5 [2.0]                               
      Glands, Hyperplasia                              1 [3.0]                                                                      
      Goblet Cell, Hyperplasia                         1 [3.0]      1 [1.0]      1 [3.0]      4 [2.0]                               
      Nasolacrimal Duct, Inflammation, Suppurative     1 [2.0]                                                                      
      Olfactory Epithelium, Degeneration, Hyaline      2 [2.0]      8 [1.3]      2 [1.5]      3 [1.7]                               
      Respiratory Epithelium, Hyperplasia              4 [2.3]      1 [3.0]      1 [1.0]      1 [2.0]                               
      Turbinate, Hyperplasia, Atypical                                                        1 [4.0]                               
      Turbinate, Necrosis                              1 [3.0]                                                                      
   Pleura                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                         2 [1.0]     12 [1.6]      5 [1.6]      1 [3.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 12:20:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      138          550          1100                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic                           11 [1.4]      2 [2.5]      1 [1.0]      5 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (49)         (50)                                   
      Atrophy                                          1 [4.0]                                                                      
      Inflammation, Suppurative                                     1 [3.0]                                                         
      Lens, Cataract                                   6 [3.2]      1 [2.0]      3 [3.7]      2 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                                                    2                                     
      Hemorrhage                                                                              1 [4.0]                               
      Nephropathy, Chronic                            50 [2.0]     49 [2.3]     50 [2.5]     50 [2.8]                               
      Cortex, Infarct                                  2 [3.5]      1 [4.0]      1 [3.0]      2 [4.0]                               
      Cortex, Renal Tubule, Accumulation, Hyaline                                                                                   
        Droplet                                        2 [2.5]      5 [3.0]      3 [3.0]      2 [3.0]                               
      Cortex, Renal Tubule, Casts Granular                          1 [3.0]      1 [1.0]      3 [1.0]                               
      Cortex, Renal Tubule, Hyperplasia                             1 [3.0]      8 [2.3]     23 [2.4]                               
      Cortex, Renal Tubule, Mineralization                                                    1 [2.0]                               
      Medulla, Casts Granular                                       3 [2.0]      1 [1.0]      3 [1.7]                               
      Papilla, Mineralization                          1 [1.0]      8 [1.1]     30 [1.9]     39 [2.2]                               
      Papilla, Necrosis                                             1 [4.0]                                                         
      Pelvis, Dilatation                                            1 [4.0]      1 [4.0]      1 [2.0]                               
      Pelvis, Transitional Epithelium, Hyperplasia                  2 [2.0]      8 [2.1]      5 [3.0]                               
      Renal Tubule, Mineralization                                  1 [4.0]                                                         
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 [4.0]      1 [4.0]      1 [4.0]                               
      Inflammation, Chronic                                         1 [4.0]                                                         
      Muscularis, Transitional Epithelium,                                                                                          
        Mineralization                                              1 [4.0]                                                         
      Transitional Epithelium, Hyperplasia                                                    1 [3.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.