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TDMS Study 96001-06 Pathology Tables

NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56

                                                         FINAL #1 MICE




       Facility:  Battelle Northwest

       Chemical CAS #:  64742-88-7

       Lock Date:  09/25/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6           11           11           10                                     
    Natural Death                                      8            5           12            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           34           27           34                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (43)         (45)         (44)         (47)                                   
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
   Intestine Small, Jejunum                           (43)         (47)         (43)         (47)                                   
      Necrosis                                                                   1 (2%)                                             
   Intestine Small, Ileum                             (43)         (47)         (44)         (46)                                   
      Inflammation                                                                            1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Basophilic Focus                                 4 (8%)       5 (10%)      8 (16%)      4 (8%)                                
      Clear Cell Focus                                 4 (8%)                    2 (4%)       2 (4%)                                
      Eosinophilic Focus                               4 (8%)       9 (18%)      6 (12%)     11 (22%)                               
      Fatty Change                                                  2 (4%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Infarct                                          1 (2%)                                                                       
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                                                               1 (2%)                                
      Mixed Cell Focus                                                           1 (2%)       1 (2%)                                
      Necrosis                                         3 (6%)       3 (6%)       1 (2%)                                             
      Parasite Metazoan                                             1 (2%)                                                          
      Tension Lipidosis                                2 (4%)                    1 (2%)       2 (4%)                                
      Centrilobular, Necrosis                          1 (2%)       2 (4%)                                                          
   Mesentery                                          (4)          (15)         (21)         (11)                                   
      Artery, Mineralization                                        1 (7%)                                                          
      Fat, Hemorrhage                                               1 (7%)       1 (5%)       1 (9%)                                
      Fat, Necrosis                                    3 (75%)     10 (67%)     15 (71%)      9 (82%)                               
   Pancreas                                           (49)         (50)         (48)         (49)                                   
      Atrophy                                                       2 (4%)                                                          
      Atypia Cellular                                  1 (2%)                                                                       
      Inflammation, Suppurative                                                               1 (2%)                                
      Lipomatosis                                                                1 (2%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Hypertrophy                                                                     1 (2%)                                
      Duct, Cyst                                                    2 (4%)                    1 (2%)                                
   Salivary Glands                                    (50)         (49)         (49)         (50)                                   
      Atrophy                                                       1 (2%)       1 (2%)                                             
   Stomach, Forestomach                               (49)         (50)         (49)         (50)                                   
      Hyperplasia, Squamous                            2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                  2 (4%)       1 (2%)                                             
      Ulcer                                            1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (47)         (49)         (47)         (47)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Mineralization                                                1 (2%)       1 (2%)       1 (2%)                                
      Necrosis                                                      1 (2%)       1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (2)                                    
      Aorta, Mineralization                            1 (100%)                               2 (100%)                              
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   6 (12%)      6 (12%)      6 (12%)      9 (18%)                               
      Mineralization                                   3 (6%)       4 (8%)                    4 (8%)                                
      Thrombosis                                       2 (4%)                                                                       
      Artery, Inflammation                             1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia                                      4 (8%)       3 (6%)       3 (6%)       6 (12%)                               
      Hypertrophy                                      2 (4%)       3 (6%)       2 (4%)       3 (6%)                                
      Necrosis                                                                   1 (2%)                                             
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
   Adrenal Medulla                                    (49)         (50)         (48)         (49)                                   
      Hyperplasia                                      2 (4%)       3 (6%)       4 (8%)       2 (4%)                                
   Islets, Pancreatic                                 (49)         (50)         (48)         (48)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (47)         (49)         (49)         (48)                                   
      Angiectasis                                      1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      10 (21%)     12 (24%)     16 (33%)     16 (33%)                               
      Pars Intermedia, Hypertrophy                                               1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (47)         (48)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia                                  2 (4%)       1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                                                              
      Inflammation, Acute                                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (40)         (42)         (47)         (41)                                   
      Fibrosis                                                      1 (2%)                                                          
   Ovary                                              (49)         (50)         (48)         (49)                                   
      Angiectasis                                      2 (4%)                                                                       
      Cyst                                            12 (24%)     12 (24%)      9 (19%)      6 (12%)                               
   Uterus                                             (49)         (50)         (49)         (49)                                   
      Angiectasis                                      1 (2%)                                                                       
      Inflammation, Suppurative                                                               1 (2%)                                
      Endometrium, Hyperplasia, Cystic                 5 (10%)      3 (6%)       9 (18%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (48)         (50)                                   
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Cytoplasmic Alteration, Focal                                 1 (2%)                                                          
      Hyperplasia                                                                             1 (2%)                                
   Lymph Node                                         (5)          (7)          (9)          (10)                                   
      Angiectasis                                                                             1 (10%)                               
      Iliac, Angiectasis                                                                      2 (20%)                               
      Renal, Angiectasis                               1 (20%)      2 (29%)      1 (11%)      1 (10%)                               
      Renal, Ectasia                                                             1 (11%)                                            
   Lymph Node, Mandibular                             (42)         (32)         (40)         (40)                                   
      Infiltration Cellular, Plasma Cell                                                      1 (3%)                                
   Lymph Node, Mesenteric                             (47)         (49)         (47)         (50)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
   Lymph Node, Mediastinal                            (40)         (42)         (43)         (43)                                   
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
   Spleen                                             (49)         (50)         (48)         (47)                                   
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Congestion                                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                 2 (4%)       8 (16%)      5 (10%)      3 (6%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                    1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
   Thymus                                             (43)         (45)         (47)         (46)                                   
      Atrophy                                                                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Mixed Cell                1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
        Inclusion                                      1 (2%)                                                                       
      Subcutaneous Tissue, Edema                                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fracture                                                      1 (2%)       1 (2%)                                             
   Skeletal Muscle                                    (1)          (1)          (1)          (2)                                    
      Hemorrhage                                                    1 (100%)                                                        
      Inflammation, Suppurative                                                               1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                                   1 (2%)                                                          
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Artery, Inflammation                             1 (2%)                                                                       
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
        Cell                                           6 (12%)      2 (4%)       2 (4%)       3 (6%)                                
   Peripheral Nerve                                                             (1)          (1)                                    
      Inflammation, Suppurative                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Artery, Inflammation                                                       1 (2%)                                             
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 1 (2%)       3 (6%)       1 (2%)       3 (6%)                                
      Alveolus, Infiltration Cellular, Histiocyte                                1 (2%)       1 (2%)                                
   Nose                                               (49)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       1 (2%)                                
      Respiratory Epithelium, Degeneration                          1 (2%)                                                          
   Trachea                                            (49)         (50)         (49)         (47)                                   
      Artery, Inflammation                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (46)         (49)         (45)         (46)                                   
      Cataract                                         1 (2%)       2 (4%)       2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Cornea, Inflammation, Chronic Active                          1 (2%)       1 (2%)       2 (4%)                                
   Harderian Gland                                    (49)         (49)         (49)         (49)                                   
      Hyperplasia                                      4 (8%)       3 (6%)       4 (8%)       7 (14%)                               
      Infiltration Cellular                                                      1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (49)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Cyst                                             1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Inflammation, Suppurative                                                               1 (2%)                                
      Metaplasia, Osseous                                           2 (4%)       1 (2%)       2 (4%)                                
      Mineralization                                   1 (2%)       1 (2%)                    2 (4%)                                
      Nephropathy                                     39 (78%)     32 (64%)     33 (67%)     40 (82%)                               
      Capsule, Fibrosis                                1 (2%)                                                                       
      Papilla, Necrosis                                                                       1 (2%)                                
      Pelvis, Dilatation                                            1 (2%)                                                          
      Renal Tubule, Karyomegaly                                     1 (2%)                                                          
      Renal Tubule, Necrosis                                                                  1 (2%)                                
   Urinary Bladder                                    (48)         (50)         (49)         (48)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            9           16           13                                     
    Natural Death                                      9            9            6            5                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32           27           32                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (39)         (36)         (41)         (43)                                   
      Degeneration, Hyaline                                         1 (3%)                                                          
      Hyperplasia                                      1 (3%)                                                                       
      Infiltration Cellular, Mixed Cell                1 (3%)                                                                       
      Inflammation, Chronic Active                                  1 (3%)                                                          
   Intestine Large, Cecum                             (45)         (41)         (46)         (47)                                   
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
   Intestine Small, Duodenum                          (46)         (41)         (46)         (47)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (41)         (46)         (47)                                   
      Serosa, Inflammation, Granulomatous              1 (2%)                                                                       
   Intestine Small, Ileum                             (45)         (41)         (46)         (47)                                   
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
      Inflammation                                                  1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Basophilic Focus                                 9 (18%)     13 (26%)     17 (34%)     11 (22%)                               
      Clear Cell Focus                                13 (26%)     11 (22%)     15 (30%)     10 (20%)                               
      Eosinophilic Focus                               5 (10%)      7 (14%)     14 (28%)      9 (18%)                               
      Fatty Change                                     1 (2%)                    1 (2%)                                             
      Infarct                                          1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Mitotic Alteration                                            1 (2%)                                                          
      Mixed Cell Focus                                 2 (4%)       1 (2%)                    1 (2%)                                
      Necrosis                                         4 (8%)       4 (8%)       2 (4%)       4 (8%)                                
      Tension Lipidosis                                2 (4%)       3 (6%)       1 (2%)       2 (4%)                                
      Bile Duct, Cyst                                                                         1 (2%)                                
      Centrilobular, Necrosis                          1 (2%)                                 1 (2%)                                
   Mesentery                                          (6)          (6)          (7)          (5)                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation                             1 (17%)                   1 (14%)                                            
      Fat, Hemorrhage                                               1 (17%)                                                         
      Fat, Necrosis                                    4 (67%)      5 (83%)      5 (71%)      5 (100%)                              
   Pancreas                                           (49)         (49)         (49)         (50)                                   
      Atrophy                                          1 (2%)       1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
   Stomach, Forestomach                               (49)         (48)         (49)         (49)                                   
      Hyperplasia, Squamous                            5 (10%)      3 (6%)                    4 (8%)                                
      Inflammation, Chronic Active                     5 (10%)      1 (2%)                    2 (4%)                                
      Ulcer                                            2 (4%)       1 (2%)                    2 (4%)                                
   Stomach, Glandular                                 (48)         (44)         (49)         (48)                                   
      Degeneration, Hyaline                                                                   1 (2%)                                
      Hyperplasia                                                   1 (2%)                                                          
      Mineralization                                   2 (4%)       1 (2%)                                                          
      Necrosis                                         2 (4%)                    1 (2%)       1 (2%)                                
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
   Tongue                                                                                    (1)                                    
      Mineralization                                                                          1 (100%)                              
   Tooth                                              (19)         (16)         (21)         (17)                                   
      Malformation                                                                            1 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)          (1)                                    
      Aorta, Mineralization                                                      1 (100%)                                           
   Heart                                              (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                                   1 (2%)                                                          
      Cardiomyopathy                                  15 (30%)     12 (24%)     21 (42%)     19 (38%)                               
      Infiltration Cellular, Polymorphonuclear                                   1 (2%)                                             
      Mineralization                                   1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Thrombosis                                                    1 (2%)       1 (2%)       1 (2%)                                
      Artery, Inflammation                                                       1 (2%)                                             
      Capillary, Endothelium, Hyperplasia                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (49)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia                                     13 (27%)     10 (20%)      7 (14%)     15 (30%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hypertrophy                                     30 (61%)     29 (58%)     20 (41%)     20 (40%)                               
   Adrenal Medulla                                    (48)         (49)         (49)         (50)                                   
      Hyperplasia                                      3 (6%)       4 (8%)       3 (6%)       1 (2%)                                
   Islets, Pancreatic                                 (48)         (49)         (49)         (50)                                   
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (49)         (49)         (48)         (46)                                   
      Pars Distalis, Hyperplasia                       2 (4%)                    2 (4%)       2 (4%)                                
      Pars Intermedia, Hyperplasia                                                            1 (2%)                                
   Thyroid Gland                                      (49)         (48)         (47)         (50)                                   
      Follicular Cell, Hyperplasia                     3 (6%)       2 (4%)       3 (6%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)          (1)          (1)                                                 
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                            (2)                                                 
      Hyperplasia                                                                1 (50%)                                            
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  3 (6%)                    3 (6%)       2 (4%)                                
      Infiltration Cellular, Mononuclear Cell                                                 1 (2%)                                
   Penis                                                           (3)                       (1)                                    
      Inflammation, Acute                                           2 (67%)                   1 (100%)                              
   Preputial Gland                                    (49)         (49)         (50)         (48)                                   
      Ectasia                                          1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)       3 (6%)       2 (4%)       1 (2%)                                
   Prostate                                           (46)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 (2%)       1 (2%)                    1 (2%)                                
      Artery, Inflammation                                                       1 (2%)                                             
   Seminal Vesicle                                    (48)         (46)         (50)         (48)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Infiltration Cellular, Mononuclear Cell                       1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Mineralization                                                1 (2%)                                                          
      Germinal Epithelium, Degeneration                1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                   2 (4%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (1)                       (1)          (3)                                    
      Deep Cervical, Hyperplasia, Lymphoid                                                    1 (33%)                               
      Lumbar, Infiltration Cellular, Plasma Cell                                              2 (67%)                               
   Lymph Node, Mesenteric                             (48)         (46)         (48)         (48)                                   
      Angiectasis                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
   Lymph Node, Mediastinal                            (39)         (40)         (36)         (43)                                   
      Infiltration Cellular, Plasma Cell                                                      1 (2%)                                
   Spleen                                             (49)         (49)         (49)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                                                1 (2%)                                             
      Hematopoietic Cell Proliferation                              3 (6%)       3 (6%)       2 (4%)                                
   Thymus                                             (41)         (39)         (40)         (42)                                   
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Infiltration Cellular, Mixed Cell                1 (2%)                                                                       
      Inflammation, Chronic Active                     6 (12%)      7 (14%)     11 (22%)     18 (36%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Intervertebral Disc, Necrosis                                              1 (2%)                                             
   Skeletal Muscle                                                                           (1)                                    
      Inflammation, Suppurative                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                                                1 (2%)                                             
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
        Cell                                                                     1 (2%)                                             
   Spinal Cord                                                                               (1)                                    
      Degeneration                                                                            1 (100%)                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (50)                                   
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                                                            1 (2%)                                
      Thrombosis                                       1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              4 (8%)                    2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte      2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Bronchiole, Hyperplasia                          2 (4%)                                                                       
      Mediastinum, Thrombosis                                       1 (2%)                                                          
   Nose                                               (50)         (48)         (50)         (50)                                   
      Inflammation, Suppurative                        3 (6%)       2 (4%)       1 (2%)       2 (4%)                                
      Polyp, Inflammatory                              1 (2%)                    1 (2%)                                             
      Olfactory Epithelium, Atrophy                    3 (6%)       1 (2%)       2 (4%)                                             
      Olfactory Epithelium, Inflammation,                                                                                           
        Granulomatous                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (46)         (46)         (47)         (46)                                   
      Cornea, Inflammation, Chronic Active                          3 (7%)       1 (2%)       1 (2%)                                
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia                                      3 (6%)       4 (8%)       1 (2%)       1 (2%)                                
   Zymbal's Gland                                     (1)                                    (1)                                    
      Cyst                                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Cyst                                             3 (6%)       1 (2%)       3 (6%)       1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                    2 (4%)       2 (4%)                                
      Metaplasia, Osseous                              3 (6%)       4 (8%)                    2 (4%)                                
      Nephropathy                                     44 (88%)     43 (86%)     42 (86%)     44 (88%)                               
      Capsule, Fibrosis                                1 (2%)                                 1 (2%)                                
      Papilla, Necrosis                                             1 (2%)       1 (2%)                                             
      Pelvis, Dilatation                                            1 (2%)                    2 (4%)                                
      Renal Tubule, Hyperplasia                        2 (4%)       1 (2%)                                                          
      Renal Tubule, Necrosis                                        2 (4%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:00:56    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                                       1 (2%)       2 (4%)                                
   Urinary Bladder                                    (49)         (46)         (49)         (50)                                   
      Infiltration Cellular, Mixed Cell                             1 (2%)       1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       2 (4%)                                
      Transitional Epithelium, Hyperplasia             1 (2%)                    1 (2%)       1 (2%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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