National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4831

TDMS Study 96001-06 Pathology Tables

NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21

                                                         FINAL #1 MICE




       Facility:  Battelle Northwest

       Chemical CAS #:  64742-88-7

       Lock Date:  09/25/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6           11           11           10                                     
    Natural Death                                      8            5           12            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           34           27           34                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (40)         (43)         (32)         (45)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
   Intestine Large, Rectum                            (44)         (48)         (44)         (47)                                   
   Intestine Large, Cecum                             (43)         (47)         (44)         (46)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Small, Duodenum                          (43)         (45)         (44)         (47)                                   
      Carcinoma                                                                               1 (2%)                                
   Intestine Small, Jejunum                           (43)         (47)         (43)         (47)                                   
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (43)         (47)         (44)         (46)                                   
      Carcinoma                                                                  1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
      Hepatocellular Carcinoma                         4 (8%)       7 (14%)      4 (8%)       6 (12%)                               
      Hepatocellular Carcinoma, Multiple               2 (4%)                    1 (2%)                                             
      Hepatocellular Adenoma                           9 (18%)      9 (18%)     11 (22%)     11 (22%)                               
      Hepatocellular Adenoma, Multiple                              3 (6%)       4 (8%)       7 (14%)                               
      Hepatocholangiocarcinoma                                      2 (4%)                                                          
      Hepatocholangiocarcinoma, Multiple                                                      1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Mesentery                                          (4)          (15)         (21)         (11)                                   
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (5%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (9%)                                
      Histiocytic Sarcoma                                                                     1 (9%)                                
      Sarcoma                                                       1 (7%)                                                          
      Sarcoma, Metastatic, Skin                                                  2 (10%)                                            
   Oral Mucosa                                        (1)                                                                           
      Pharyngeal, Squamous Cell Carcinoma              1 (100%)                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Pancreas                                           (49)         (50)         (48)         (49)                                   
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (49)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (49)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Squamous Cell Papilloma                                                    1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (47)         (49)         (47)         (47)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Subcapsular, Adenoma                             1 (2%)       1 (2%)                                                          
   Adrenal Medulla                                    (49)         (50)         (48)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)                                 1 (2%)                                
   Islets, Pancreatic                                 (49)         (50)         (48)         (48)                                   
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (47)         (49)         (49)         (48)                                   
      Pars Distalis, Adenoma                          10 (21%)      8 (16%)     10 (20%)     10 (21%)                               
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (47)         (48)                                   
      Follicular Cell, Adenoma                         2 (4%)                                                                       
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (40)         (42)         (47)         (41)                                   
      Carcinoma                                                                               1 (2%)                                
   Ovary                                              (49)         (50)         (48)         (49)                                   
      Carcinoma                                                     1 (2%)                                                          
      Cystadenoma                                      1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
      Granulosa-Theca Tumor Benign                                               1 (2%)                                             
      Hemangioma                                       1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)       2 (4%)                    1 (2%)                                
      Sarcoma, Metastatic, Skin                                                  2 (4%)                                             
      Teratoma Benign                                  1 (2%)                                                                       
   Uterus                                             (49)         (50)         (49)         (49)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                     1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                           2 (4%)                    1 (2%)                                
      Polyp Stromal                                    2 (4%)                                 1 (2%)                                
      Sarcoma Stromal                                  1 (2%)                                                                       
      Sarcoma Stromal, Multiple                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (48)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
   Lymph Node                                         (5)          (7)          (9)          (10)                                   
      Lumbar, Hemangiosarcoma, Metastatic, Spleen                                             1 (10%)                               
      Lumbar, Histiocytic Sarcoma                      1 (20%)                                                                      
      Lumbar, Sarcoma Stromal, Metastatic, Uterus                   1 (14%)                                                         
      Renal, Histiocytic Sarcoma                       1 (20%)      1 (14%)                                                         
   Lymph Node, Bronchial                              (41)         (37)         (40)         (42)                                   
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (3%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (3%)                    1 (2%)                                
      Histiocytic Sarcoma                                           1 (3%)       1 (3%)       1 (2%)                                
   Lymph Node, Mandibular                             (42)         (32)         (40)         (40)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                              2 (5%)       1 (3%)                    1 (3%)                                
   Lymph Node, Mesenteric                             (47)         (49)         (47)         (50)                                   
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Lymph Node, Mediastinal                            (40)         (42)         (43)         (43)                                   
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (2%)                                             
      Hemangioma                                                    1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              2 (5%)       1 (2%)                    2 (5%)                                
   Spleen                                             (49)         (50)         (48)         (47)                                   
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                              2 (4%)                    1 (2%)       1 (2%)                                
   Thymus                                             (43)         (45)         (47)         (46)                                   
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                    1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basosquamous Tumor Malignant                                                            1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (2%)                    3 (6%)       2 (4%)                                
      Subcutaneous Tissue, Sarcoma, Multiple                                     2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (1)          (1)          (2)                                    
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                                          2 (4%)                                
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Skin                                                                               1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       4 (8%)       1 (2%)       3 (6%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Nose                                               (49)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Sarcoma                                          1 (2%)                                                                       
   Pleura                                                          (1)          (1)                                                 
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (100%)                                           
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (46)         (49)         (45)         (46)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Sarcoma                                          1 (2%)                                                                       
   Harderian Gland                                    (49)         (49)         (49)         (49)                                   
      Adenoma                                          4 (8%)       2 (4%)       4 (8%)       3 (6%)                                
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - cont                                                                                                        
      Bilateral, Adenoma                                                         2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (49)                                   
      Carcinoma, Metastatic, Intestine Small, Ileum                              1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
   Urinary Bladder                                    (48)         (50)         (49)         (48)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Lymphoma Malignant                               5 (10%)      9 (18%)     11 (22%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          41          41          39                                       
     Total Primary Neoplasms                           61          65          62          66                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27          24          30          27                                       
     Total Benign Neoplasms                            38          32          38          38                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          26          23          23                                       
     Total Malignant Neoplasms                         23          33          24          28                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           8           4           6                                       
     Total Metastatic Neoplasm                          6          11          21          19                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            9           16           13                                     
    Natural Death                                      9            9            6            5                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32           27           32                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (46)         (41)         (46)         (47)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Intestine Small, Jejunum                           (46)         (41)         (46)         (47)                                   
      Carcinoma                                                     3 (7%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Intestine Small, Ileum                             (45)         (41)         (46)         (47)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                                               2 (4%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)       3 (6%)                                             
      Hepatoblastoma                                                                          1 (2%)                                
      Hepatocellular Carcinoma                        10 (20%)     11 (22%)     12 (24%)      9 (18%)                               
      Hepatocellular Carcinoma, Multiple               6 (12%)      4 (8%)       5 (10%)      1 (2%)                                
      Hepatocellular Adenoma                          13 (26%)     16 (32%)     14 (28%)     11 (22%)                               
      Hepatocellular Adenoma, Multiple                10 (20%)     12 (24%)      7 (14%)     18 (36%)                               
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Ito Cell Tumor Benign                                         1 (2%)                                                          
      Sarcoma                                                       1 (2%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Mesentery                                          (6)          (6)          (7)          (5)                                    
      Sarcoma, Metastatic, Skin                        1 (17%)                                                                      
   Pancreas                                           (49)         (49)         (49)         (50)                                   
      Sarcoma                                                       1 (2%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (48)         (49)         (49)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Squamous Cell Carcinoma                                                                 1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                                                    2 (4%)       1 (2%)                                
   Stomach, Glandular                                 (48)         (44)         (49)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (49)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma, Metastatic, Parathyroid Gland                                                1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Bilateral, Subcapsular, Adenoma                               1 (2%)                                                          
      Subcapsular, Adenoma                             3 (6%)       2 (4%)       1 (2%)       1 (2%)                                
      Subcapsular, Carcinoma                                                     1 (2%)                                             
   Adrenal Medulla                                    (48)         (49)         (49)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Islets, Pancreatic                                 (48)         (49)         (49)         (50)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (49)         (49)         (48)         (46)                                   
   Thyroid Gland                                      (49)         (48)         (47)         (50)                                   
      C-Cell, Carcinoma                                                                       1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)          (1)          (1)                                                 
      Histiocytic Sarcoma                                                        1 (100%)                                           
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                            (2)                                                 
      Adenoma                                                                    1 (50%)                                            
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Preputial Gland                                    (49)         (49)         (50)         (48)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Prostate                                           (46)         (50)         (50)         (50)                                   
   Seminal Vesicle                                    (48)         (46)         (50)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                       1 (2%)       2 (4%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Lymph Node                                         (1)                       (1)          (3)                                    
      Pancreatic, Hepatocellular Carcinoma,                                                                                         
          Metastatic, Liver                                                      1 (100%)                                           
   Lymph Node, Bronchial                              (38)         (32)         (28)         (28)                                   
      Hemangiosarcoma                                  1 (3%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (4%)                                
      Histiocytic Sarcoma                                           1 (3%)                                                          
   Lymph Node, Mandibular                             (29)         (26)         (26)         (36)                                   
   Lymph Node, Mesenteric                             (48)         (46)         (48)         (48)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Sarcoma                                                       1 (2%)                                                          
   Lymph Node, Mediastinal                            (39)         (40)         (36)         (43)                                   
      Hemangiosarcoma                                  1 (3%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (3%)                                 1 (2%)                                
      Histiocytic Sarcoma                                           1 (3%)                                                          
      Sarcoma, Metastatic, Skin                        1 (3%)                                                                       
   Spleen                                             (49)         (49)         (49)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Thymus                                             (41)         (39)         (40)         (42)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Melanoma Malignant                               1 (2%)                                 1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma                                               1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                       2 (4%)       1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     5 (10%)      2 (4%)       3 (6%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   5 (10%)      2 (4%)       4 (8%)       5 (10%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)                                                                       
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Parathyroid Gland                                                1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)      6 (12%)      9 (18%)      3 (6%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Adenoma                                          6 (12%)      6 (12%)      5 (10%)      4 (8%)                                
      Carcinoma                                                     4 (8%)       3 (6%)       3 (6%)                                
      Bilateral, Adenoma                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)       3 (6%)                                             
      Lymphoma Malignant                               3 (6%)       1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96001-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 09/25/02  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:09:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          43          41          41                                       
     Total Primary Neoplasms                           73          75          68          68                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 32          31          30          33                                       
     Total Benign Neoplasms                            43          44          34          39                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          23          25          23                                       
     Total Malignant Neoplasms                         30          31          34          29                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           7          10           5                                       
     Total Metastatic Neoplasm                         16           7          14           8                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.