National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4837

TDMS Study 96001-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 09/25/02       
EXPERIMENT: 96001 TEST: 06                                                                                     TIME: 11:12:26       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 64742-88-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 09/25/02       
EXPERIMENT: 96001 TEST: 06                                                                                     TIME: 11:12:26       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 64742-88-7      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF            STODDARD SOLVENT (TYPE IIC)                                                                           
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hypertrophy                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Eosinophilic Focus                                                                           
Lymph Node: Lumbar                     Infiltration Cellular Plasma Cell                                                            
Skin                                   Inflammation Chronic                                                                         
Stomach, Forestomach                   Hyperplasia                                                                                  
                                       Inflammation Chronic                                                                         
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Kidney                                 Nephropathy                                                                                  
Liver                                  Eosinophilic Focus                                                                           
                                       Necrosis                                                                                     
Mesentery: Fat                         Necrosis                                                                                     
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
Spleen                                 Hematopoietic Cell Proliferation                                                             
===============================================================                                                                     
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/49 (27%)  10/50 (20%)  7/49 (14%)   15/50 (30%) |4/50 (8%)    3/50 (6%)    3/49 (6%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     13/44.15     10/43.81     7/40.92      15/44.28    |4/45.31      3/43.78      3/42.51      6/44.68      | 
|POLY-3 PERCENT (g) |     29.4%        22.8%        17.1%        33.9%       |8.8%         6.9%         7.1%         13.4%        | 
|TERMINAL (d)       |     11/34 (32%)  8/32 (25%)   5/27 (19%)   10/32 (31%) |4/36 (11%)   2/34 (6%)    2/27 (7%)    6/34 (18%)   | 
|FIRST INCIDENCE    |     534          646          703          557         |730 (T)      620          600          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.261      P=0.360N     P=0.225N     P=0.357     |P=0.217      P=0.528N     P=0.634N     P=0.331      | 
|POLY 3             |     P=0.306      P=0.321N     P=0.137N     P=0.413     |P=0.237      P=0.519N     P=0.535N     P=0.360      | 
|POLY 1.5           |     P=0.312      P=0.314N     P=0.128N     P=0.420     |P=0.236      P=0.512N     P=0.528N     P=0.361      | 
|POLY 6             |     P=0.303      P=0.327N     P=0.146N     P=0.410     |P=0.240      P=0.527N     P=0.549N     P=0.363      | 
|LOGISTIC REGRESSION|     P=0.287      P=0.314N     P=0.134N     P=0.406     |P=0.241      P=0.528N     P=0.544N     P=0.331      | 
|COCH-ARM / FISHERS |     P=0.327      P=0.298N     P=0.105N     P=0.437     |P=0.240      P=0.500N     P=0.511N     P=0.370      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     30/49 (61%)  29/50 (58%)  20/49 (41%)  20/50 (40%) |2/50 (4%)    3/50 (6%)    2/49 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     30/43.81     29/43.79     20/41.93     20/43.23    |2/45.31      3/43.40      2/42.07      3/44.68      | 
|POLY-3 PERCENT (g) |     68.5%        66.2%        47.7%        46.3%       |4.4%         6.9%         4.8%         6.7%         | 
|TERMINAL (d)       |     27/34 (79%)  26/32 (81%)  16/27 (59%)  18/32 (56%) |2/36 (6%)    3/34 (9%)    2/27 (7%)    3/34 (9%)    | 
|FIRST INCIDENCE    |     651          659          478          593         |730 (T)      730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.018N*    P=0.542      P=0.189N     P=0.045N*   |P=0.423      P=0.474      P=0.588      P=0.474      | 
|POLY 3             |     P=0.007N**   P=0.501N     P=0.034N*    P=0.023N*   |P=0.451      P=0.480      P=0.667      P=0.494      | 
|POLY 1.5           |     P=0.008N**   P=0.483N     P=0.036N*    P=0.024N*   |P=0.450      P=0.488      P=0.673      P=0.494      | 
|POLY 6             |     P=0.006N**   P=0.526N     P=0.030N*    P=0.023N*   |P=0.454      P=0.471      P=0.655      P=0.496      | 
|LOGISTIC REGRESSION|     P=0.012N*    P=0.522N     P=0.049N*    P=0.033N*   |P=0.423      P=0.474      P=0.588      P=0.474      | 
|COCH-ARM / FISHERS |     P=0.011N*    P=0.452N     P=0.034N*    P=0.028N*   |P=0.455      P=0.500      P=0.684      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/48 (6%)    4/49 (8%)    3/49 (6%)    1/50 (2%)   |2/49 (4%)    3/50 (6%)    4/48 (8%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     3/43.18      4/43.65      3/40.94      1/42.54     |2/44.60      3/43.40      4/41.50      2/43.82      | 
|POLY-3 PERCENT (g) |     7.0%         9.2%         7.3%         2.4%        |4.5%         6.9%         9.6%         4.6%         | 
|TERMINAL (d)       |     2/34 (6%)    2/32 (6%)    1/27 (4%)    1/32 (3%)   |2/36 (6%)    3/34 (9%)    2/27 (7%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     628          403          681          729 (T)     |730 (T)      730 (T)      708          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.214N     P=0.480      P=0.585      P=0.329N    |P=0.571      P=0.474      P=0.224      P=0.675      | 
|POLY 3             |     P=0.197N     P=0.506      P=0.638      P=0.310N    |P=0.573N     P=0.487      P=0.304      P=0.688      | 
|POLY 1.5           |     P=0.188N     P=0.508      P=0.647      P=0.302N    |P=0.573N     P=0.496      P=0.312      P=0.688      | 
|POLY 6             |     P=0.208N     P=0.503      P=0.629      P=0.320N    |P=0.568N     P=0.476      P=0.290      P=0.689      | 
|LOGISTIC REGRESSION|     P=0.173N     P=0.542      P=0.646      P=0.303N    |P=0.563N     P=0.474      P=0.265      P=0.675      | 
|COCH-ARM / FISHERS |     P=0.174N     P=0.512      P=0.651N     P=0.293N    |P=0.567N     P=0.510      P=0.329      P=0.691N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta                                                                                                              | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     1/1 (100%)   0/1 (0%)    |1/1 (100%)   0/0 (0%)     0/0 (0%)     2/2 (100%)   | 
|POLY-3 RATE (b)    |     0/0.00       0/0.00       1/1.00       0/0.54      |1/1.00       0/0.00       0/0.00       2/2.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         100.0%       0.0%        |100.0%       0.0%         0.0%         100.0%       | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          723          ---         |649          ---          ---          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=1.000N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain: Meninges                                                                                                                  | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |6/50 (12%)   2/50 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/43.60      0/43.29      1/41.34      0/42.54     |6/45.31      2/43.40      2/43.13      3/44.68      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         0.0%        |13.2%        4.6%         4.6%         6.7%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    1/27 (4%)    0/32 (0%)   |6/36 (17%)   2/34 (6%)    1/27 (4%)    3/34 (9%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |730 (T)      730 (T)      639          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.681      (e)          P=0.454      (e)         |P=0.266N     P=0.151N     P=0.231N     P=0.268N     | 
|POLY 3             |     P=0.688      (e)          P=0.489      (e)         |P=0.231N     P=0.147N     P=0.149N     P=0.249N     | 
|POLY 1.5           |     P=0.691      (e)          P=0.492      (e)         |P=0.234N     P=0.141N     P=0.144N     P=0.249N     | 
|POLY 6             |     P=0.684      (e)          P=0.487      (e)         |P=0.226N     P=0.153N     P=0.159N     P=0.245N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.454      (e)         |P=0.234N     P=0.151N     P=0.168N     P=0.268N     | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.234N     P=0.134N     P=0.134N     P=0.243N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    3/50 (6%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     3/43.91      0/43.29      3/41.42      2/42.54     |                                                    | 
|POLY-3 PERCENT (g) |     6.8%         0.0%         7.2%         4.7%        |                                                    | 
|TERMINAL (d)       |     2/34 (6%)    0/32 (0%)    2/27 (7%)    2/32 (6%)   |                                                    | 
|FIRST INCIDENCE    |     644          ---          709          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.569      P=0.127N     P=0.577      P=0.524N    |                                                    | 
|POLY 3             |     P=0.585      P=0.121N     P=0.635      P=0.514N    |                                                    | 
|POLY 1.5           |     P=0.590      P=0.120N     P=0.642      P=0.509N    |                                                    | 
|POLY 6             |     P=0.579      P=0.122N     P=0.628      P=0.522N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.579      P=0.121N     P=0.635      P=0.514N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.596      P=0.121N     P=0.661N     P=0.500N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    0/46 (0%)    0/47 (0%)    0/46 (0%)   |1/46 (2%)    2/49 (4%)    2/45 (4%)    0/46 (0%)    | 
|POLY-3 RATE (b)    |     0/41.94      0/40.91      0/40.06      0/40.93     |1/43.38      2/43.31      2/39.69      0/42.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         4.6%         5.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |1/36 (3%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      675          634          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.299N     P=0.467      P=0.445      P=0.511N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.310N     P=0.499      P=0.469      P=0.505N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.309N     P=0.508      P=0.476      P=0.504N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.310N     P=0.490      P=0.458      P=0.505N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.297N     P=0.534      P=0.503      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.302N     P=0.524      P=0.492      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    3/46 (7%)    1/47 (2%)    1/46 (2%)   |0/46 (0%)    1/49 (2%)    1/45 (2%)    2/46 (4%)    | 
|POLY-3 RATE (b)    |     0/41.94      3/41.11      1/40.06      1/40.93     |0/43.38      1/42.90      1/39.24      2/42.33      | 
|POLY-3 PERCENT (g) |     0.0%         7.3%         2.5%         2.4%        |0.0%         2.3%         2.6%         4.7%         | 
|TERMINAL (d)       |     0/34 (0%)    2/32 (6%)    1/27 (4%)    1/32 (3%)   |0/36 (0%)    1/34 (3%)    1/27 (4%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     ---          675          729 (T)      729 (T)     |---          730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.565      P=0.116      P=0.454      P=0.488     |P=0.147      P=0.489      P=0.443      P=0.226      | 
|POLY 3             |     P=0.577      P=0.115      P=0.491      P=0.495     |P=0.145      P=0.498      P=0.480      P=0.232      | 
|POLY 1.5           |     P=0.584      P=0.116      P=0.494      P=0.497     |P=0.146      P=0.504      P=0.485      P=0.233      | 
|POLY 6             |     P=0.570      P=0.114      P=0.487      P=0.492     |P=0.146      P=0.491      P=0.472      P=0.231      | 
|LOGISTIC REGRESSION|     P=0.578      P=0.116      P=0.454      P=0.488     |(e)          P=0.489      P=0.443      P=0.226      | 
|COCH-ARM / FISHERS |     P=0.592      P=0.121      P=0.505      P=0.500     |P=0.147      P=0.516      P=0.495      P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    1/50 (2%)    1/49 (2%)   |4/49 (8%)    3/49 (6%)    4/49 (8%)    7/49 (14%)   | 
|POLY-3 RATE (b)    |     3/43.60      4/43.68      1/41.96      1/42.31     |4/44.60      3/43.60      4/42.55      7/44.47      | 
|POLY-3 PERCENT (g) |     6.9%         9.2%         2.4%         2.4%        |9.0%         6.9%         9.4%         15.7%        | 
|TERMINAL (d)       |     3/34 (9%)    3/32 (9%)    0/27 (0%)    0/32 (0%)   |4/36 (11%)   1/34 (3%)    1/27 (4%)    5/34 (15%)   | 
|FIRST INCIDENCE    |     729 (T)      618          527          669         |730 (T)      666          634          503          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.158N     P=0.473      P=0.376N     P=0.328N    |P=0.136      P=0.539N     P=0.512      P=0.233      | 
|POLY 3             |     P=0.144N     P=0.501      P=0.319N     P=0.316N    |P=0.138      P=0.512N     P=0.617      P=0.259      | 
|POLY 1.5           |     P=0.144N     P=0.499      P=0.317N     P=0.315N    |P=0.137      P=0.507N     P=0.625      P=0.257      | 
|POLY 6             |     P=0.144N     P=0.504      P=0.320N     P=0.316N    |P=0.141      P=0.519N     P=0.602      P=0.263      | 
|LOGISTIC REGRESSION|     P=0.142N     P=0.496      P=0.304N     P=0.319N    |P=0.135      P=0.519N     P=0.604      P=0.253      | 
|COCH-ARM / FISHERS |     P=0.141N     P=0.500      P=0.309N     P=0.316N    |P=0.139      P=0.500N     P=0.643N     P=0.262      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  12/50 (24%)  21/50 (42%)  19/50 (38%) |6/50 (12%)   6/50 (12%)   6/50 (12%)   9/50 (18%)   | 
|POLY-3 RATE (b)    |     15/44.98     12/44.52     21/44.20     19/45.19    |6/46.11      6/43.97      6/44.25      9/44.68      | 
|POLY-3 PERCENT (g) |     33.4%        27.0%        47.5%        42.0%       |13.0%        13.6%        13.6%        20.2%        | 
|TERMINAL (d)       |     12/34 (35%)  8/32 (25%)   12/27 (44%)  11/32 (34%) |5/36 (14%)   4/34 (12%)   2/27 (7%)    9/34 (27%)   | 
|FIRST INCIDENCE    |     525          576          509          563         |424          637          563          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.100      P=0.379N     P=0.059      P=0.223     |P=0.188      P=0.579      P=0.480      P=0.246      | 
|POLY 3             |     P=0.112      P=0.334N     P=0.121      P=0.261     |P=0.197      P=0.587      P=0.592      P=0.264      | 
|POLY 1.5           |     P=0.111      P=0.333N     P=0.123      P=0.259     |P=0.199      P=0.599      P=0.599      P=0.269      | 
|POLY 6             |     P=0.119      P=0.331N     P=0.124      P=0.273     |P=0.197      P=0.577      P=0.579      P=0.263      | 
|LOGISTIC REGRESSION|     P=0.107      P=0.331N     P=0.120      P=0.250     |P=0.208      P=0.616N     P=0.585N     P=0.279      | 
|COCH-ARM / FISHERS |     P=0.117      P=0.326N     P=0.149      P=0.263     |P=0.211      P=0.620N     P=0.620N     P=0.288      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |3/50 (6%)    4/50 (8%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/43.74      2/43.47      2/41.47      1/43.05     |3/46.76      4/44.94      0/42.80      4/45.68      | 
|POLY-3 PERCENT (g) |     2.3%         4.6%         4.8%         2.3%        |6.4%         8.9%         0.0%         8.8%         | 
|TERMINAL (d)       |     0/34 (0%)    1/32 (3%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    1/34 (3%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     694          683          702          575         |492          455          ---          408          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.572N     P=0.487      P=0.471      P=0.751     |P=0.514      P=0.479      P=0.131N     P=0.492      | 
|POLY 3             |     P=0.564N     P=0.498      P=0.481      P=0.757     |P=0.507      P=0.478      P=0.135N     P=0.487      | 
|POLY 1.5           |     P=0.561N     P=0.498      P=0.486      P=0.758     |P=0.511      P=0.487      P=0.129N     P=0.491      | 
|POLY 6             |     P=0.567N     P=0.498      P=0.477      P=0.756     |P=0.502      P=0.468      P=0.146N     P=0.486      | 
|LOGISTIC REGRESSION|     P=0.557N     P=0.498      P=0.481      P=0.746N    |P=0.576      P=0.631      P=0.064N     P=0.599      | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.500      P=0.500      P=0.753N    |P=0.521      P=0.500      P=0.121N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.60      1/43.50      1/41.44      1/42.73     |2/46.73      0/43.40      0/42.80      0/44.68      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.4%         2.3%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          673          702          681         |424          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.369      P=0.510      P=0.494      P=0.484     |P=0.119N     P=0.244N     P=0.242N     P=0.249N     | 
|POLY 3             |     P=0.377      P=0.500      P=0.490      P=0.496     |P=0.109N     P=0.254N     P=0.257N     P=0.247N     | 
|POLY 1.5           |     P=0.380      P=0.499      P=0.492      P=0.497     |P=0.111N     P=0.248N     P=0.250N     P=0.245N     | 
|POLY 6             |     P=0.374      P=0.500      P=0.488      P=0.495     |P=0.109N     P=0.261N     P=0.268N     P=0.248N     | 
|LOGISTIC REGRESSION|     P=0.383      P=0.502      P=0.491      P=0.501     |P=0.065N     P=0.093N     P=0.099N     P=0.075N     | 
|COCH-ARM / FISHERS |     P=0.384      P=0.500      P=0.500      P=0.500     |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    3/49 (6%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/43.79      1/43.29      3/40.73      1/42.54     |1/45.45      0/43.40      0/42.07      0/43.78      | 
|POLY-3 PERCENT (g) |     6.9%         2.3%         7.4%         2.4%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/34 (6%)    1/32 (3%)    3/27 (11%)   1/32 (3%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     681          729 (T)      729 (T)      729 (T)     |694          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.342N     P=0.328N     P=0.567      P=0.330N    |P=0.302N     P=0.527N     P=0.527N     P=0.490N     | 
|POLY 3             |     P=0.325N     P=0.309N     P=0.629      P=0.315N    |P=0.306N     P=0.509N     P=0.515N     P=0.507N     | 
|POLY 1.5           |     P=0.321N     P=0.308N     P=0.634      P=0.311N    |P=0.307N     P=0.505N     P=0.512N     P=0.507N     | 
|POLY 6             |     P=0.330N     P=0.310N     P=0.624      P=0.320N    |P=0.306N     P=0.514N     P=0.523N     P=0.507N     | 
|LOGISTIC REGRESSION|     P=0.331N     P=0.307N     P=0.625      P=0.317N    |P=0.309N     P=0.500N     P=0.506N     P=0.503N     | 
|COCH-ARM / FISHERS |     P=0.314N     P=0.309N     P=0.651      P=0.309N    |P=0.308N     P=0.500N     P=0.505N     P=0.505N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/49 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/43.68      0/43.29      2/41.71      2/43.55     |0/45.31      0/43.40      0/42.07      1/44.12      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         4.8%         4.6%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     710          ---          527          521         |---          ---          ---          634          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240      P=0.512N     P=0.464      P=0.491     |P=0.205      (e)          (e)          P=0.504      | 
|POLY 3             |     P=0.246      P=0.502N     P=0.484      P=0.499     |P=0.198      (e)          (e)          P=0.495      | 
|POLY 1.5           |     P=0.246      P=0.501N     P=0.484      P=0.499     |P=0.196      (e)          (e)          P=0.494      | 
|POLY 6             |     P=0.246      P=0.502N     P=0.486      P=0.499     |P=0.200      (e)          (e)          P=0.497      | 
|LOGISTIC REGRESSION|     P=0.259      P=0.501N     P=0.549      P=0.541     |P=0.198      (e)          (e)          P=0.525      | 
|COCH-ARM / FISHERS |     P=0.245      P=0.500N     P=0.492      P=0.500     |P=0.196      (e)          (e)          P=0.495      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    2/50 (4%)    1/49 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     3/43.60      4/43.29      0/40.73      2/42.62     |0/45.31      2/43.56      1/42.17      2/43.78      | 
|POLY-3 PERCENT (g) |     6.9%         9.2%         0.0%         4.7%        |0.0%         4.6%         2.4%         4.6%         | 
|TERMINAL (d)       |     3/34 (9%)    4/32 (13%)   0/27 (0%)    1/32 (3%)   |0/36 (0%)    1/34 (3%)    0/27 (0%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          710         |---          688          703          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292N     P=0.466      P=0.164N     P=0.525N    |P=0.250      P=0.222      P=0.478      P=0.226      | 
|POLY 3             |     P=0.273N     P=0.496      P=0.131N     P=0.510N    |P=0.234      P=0.228      P=0.486      P=0.229      | 
|POLY 1.5           |     P=0.270N     P=0.497      P=0.129N     P=0.507N    |P=0.235      P=0.232      P=0.489      P=0.230      | 
|POLY 6             |     P=0.275N     P=0.496      P=0.132N     P=0.514N    |P=0.236      P=0.224      P=0.480      P=0.231      | 
|LOGISTIC REGRESSION|     P=0.280N     P=0.466      (e)          P=0.520N    |P=0.242      P=0.229      P=0.490      P=0.226      | 
|COCH-ARM / FISHERS |     P=0.264N     P=0.500      P=0.125N     P=0.500N    |P=0.239      P=0.247      P=0.495      P=0.242      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/49 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/43.60      0/43.29      0/40.73      0/42.54     |1/45.60      1/43.73      0/42.07      2/43.86      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         2.3%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |649          637          ---          709          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.366      P=0.747      P=0.514N     P=0.491      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.357      P=0.751      P=0.516N     P=0.486      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.357      P=0.755      P=0.512N     P=0.487      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.357      P=0.747      P=0.524N     P=0.487      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.362      P=0.738N     P=0.483N     P=0.493      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.360      P=0.753N     P=0.505N     P=0.492      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     44/50 (88%)  43/50 (86%)  42/49 (86%)  44/50 (88%) |39/50 (78%)  32/50 (64%)  33/49 (67%)  40/49 (82%)  | 
|POLY-3 RATE (b)    |     44/47.43     43/47.53     42/46.12     44/46.66    |39/46.82     32/48.39     33/45.98     40/46.07     | 
|POLY-3 PERCENT (g) |     92.8%        90.5%        91.1%        94.3%       |83.3%        66.1%        71.8%        86.8%        | 
|TERMINAL (d)       |     33/34 (97%)  32/32 (100%) 25/27 (93%)  32/32 (100%)|32/36 (89%)  21/34 (62%)  21/27 (78%)  30/34 (88%)  | 
|FIRST INCIDENCE    |     534          398          400          557         |590          366          506          465          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.324      P=0.505      P=0.214      P=0.387     |P=0.222      P=0.242N     P=0.374      P=0.354      | 
|POLY 3             |     P=0.399      P=0.485N     P=0.534N     P=0.556     |P=0.177      P=0.038N*    P=0.127N     P=0.422      | 
|POLY 1.5           |     P=0.447      P=0.484N     P=0.558N     P=0.586     |P=0.182      P=0.054N     P=0.152N     P=0.399      | 
|POLY 6             |     P=0.350      P=0.542N     P=0.499N     P=0.503     |P=0.188      P=0.027N*    P=0.112N     P=0.482      | 
|LOGISTIC REGRESSION|     P=0.432      P=0.551N     P=0.543      P=0.534     |P=0.197      P=0.111N     P=0.241N     P=0.329      | 
|COCH-ARM / FISHERS |     P=0.530      P=0.500N     P=0.484N     P=0.620N    |P=0.231      P=0.093N     P=0.168N     P=0.421      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.60      1/43.29      0/40.73      2/43.58     |0/45.31      1/43.85      0/42.07      0/43.78      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         4.6%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    1/32 (3%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          550         |---          597          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.141      P=0.488      (e)          P=0.239     |P=0.566N     P=0.496      (e)          (e)          | 
|POLY 3             |     P=0.139      P=0.499      (e)          P=0.237     |P=0.578N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.139      P=0.499      (e)          P=0.237     |P=0.576N     P=0.496      (e)          (e)          | 
|POLY 6             |     P=0.139      P=0.498      (e)          P=0.237     |P=0.581N     P=0.491      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.142      P=0.488      (e)          P=0.282     |P=0.556N     P=0.549      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.140      P=0.500      (e)          P=0.247     |P=0.571N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/43.60      1/43.90      0/40.73      0/42.54     |0/45.31      0/43.40      0/42.07      0/43.78      | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/34 (6%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      534          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.112N     P=0.514N     P=0.290N     P=0.252N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.104N     P=0.498N     P=0.252N     P=0.242N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.103N     P=0.499N     P=0.250N     P=0.241N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.105N     P=0.495N     P=0.254N     P=0.245N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.098N     P=0.492N     (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.253N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/43.60      2/43.96      0/40.73      0/42.54     |0/45.31      0/43.40      0/42.07      1/43.86      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          582          ---          ---         |---          ---          ---          709          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.419N     P=0.234      (e)          (e)         |P=0.208      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.412N     P=0.239      (e)          (e)         |P=0.197      (e)          (e)          P=0.494      | 
|POLY 1.5           |     P=0.410N     P=0.238      (e)          (e)         |P=0.196      (e)          (e)          P=0.493      | 
|POLY 6             |     P=0.413N     P=0.241      (e)          (e)         |P=0.199      (e)          (e)          P=0.495      | 
|LOGISTIC REGRESSION|     P=0.393N     P=0.251      (e)          (e)         |P=0.197      (e)          (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.406N     P=0.247      (e)          (e)         |P=0.196      (e)          (e)          P=0.495      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/49 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.60      0/43.29      1/41.35      2/43.73     |0/45.31      0/43.40      0/42.07      0/43.78      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          527          521         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.074      (e)          P=0.487      P=0.242     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.071      (e)          P=0.489      P=0.238     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.071      (e)          P=0.490      P=0.237     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.071      (e)          P=0.489      P=0.238     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.065      (e)          P=0.598      P=0.298     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.495      P=0.247     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   13/50 (26%)  17/50 (34%)  11/50 (22%) |4/50 (8%)    5/50 (10%)   8/50 (16%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     9/44.04      13/43.99     17/42.56     11/43.44    |4/45.31      5/43.90      8/42.80      4/44.68      | 
|POLY-3 PERCENT (g) |     20.4%        29.6%        39.9%        25.3%       |8.8%         11.4%        18.7%        9.0%         | 
|TERMINAL (d)       |     8/34 (24%)   9/32 (28%)   12/27 (44%)  8/32 (25%)  |4/36 (11%)   3/34 (9%)    8/27 (30%)   4/34 (12%)   | 
|FIRST INCIDENCE    |     603          659          470          563         |730 (T)      637          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.327      P=0.202      P=0.016 *    P=0.351     |P=0.502      P=0.462      P=0.065      P=0.613      | 
|POLY 3             |     P=0.364      P=0.228      P=0.037 *    P=0.386     |P=0.540      P=0.480      P=0.149      P=0.636      | 
|POLY 1.5           |     P=0.374      P=0.229      P=0.040 *    P=0.391     |P=0.538      P=0.487      P=0.159      P=0.636      | 
|POLY 6             |     P=0.355      P=0.231      P=0.034 *    P=0.382     |P=0.547      P=0.473      P=0.132      P=0.639      | 
|LOGISTIC REGRESSION|     P=0.349      P=0.224      P=0.036 *    P=0.372     |P=0.552      P=0.467      P=0.065      P=0.613      | 
|COCH-ARM / FISHERS |     P=0.391      P=0.235      P=0.055      P=0.402     |P=0.547      P=0.500      P=0.178      P=0.643N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  11/50 (22%)  15/50 (30%)  10/50 (20%) |4/50 (8%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     13/43.60     11/43.29     15/41.42     10/42.77    |4/45.70      0/43.40      2/42.80      2/44.68      | 
|POLY-3 PERCENT (g) |     29.8%        25.4%        36.2%        23.4%       |8.8%         0.0%         4.7%         4.5%         | 
|TERMINAL (d)       |     13/34 (38%)  11/32 (34%)  14/27 (52%)  9/32 (28%)  |3/36 (8%)    0/34 (0%)    2/27 (7%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      709          669         |618          ---          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.411N     P=0.472N     P=0.149      P=0.372N    |P=0.432N     P=0.072N     P=0.456N     P=0.360N     | 
|POLY 3             |     P=0.359N     P=0.413N     P=0.344      P=0.332N    |P=0.399N     P=0.067N     P=0.368N     P=0.348N     | 
|POLY 1.5           |     P=0.352N     P=0.413N     P=0.361      P=0.327N    |P=0.402N     P=0.064N     P=0.357N     P=0.346N     | 
|POLY 6             |     P=0.365N     P=0.412N     P=0.328      P=0.335N    |P=0.394N     P=0.071N     P=0.388N     P=0.348N     | 
|LOGISTIC REGRESSION|     P=0.380N     P=0.472N     P=0.195      P=0.352N    |P=0.405N     P=0.065N     P=0.366N     P=0.342N     | 
|COCH-ARM / FISHERS |     P=0.338N     P=0.408N     P=0.412      P=0.318N    |P=0.404N     P=0.059N     P=0.339N     P=0.339N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   14/50 (28%)  9/50 (18%)  |4/50 (8%)    9/50 (18%)   6/50 (12%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |     5/44.04      7/43.80      14/41.72     9/43.29     |4/45.31      9/43.60      6/42.92      11/45.26     | 
|POLY-3 PERCENT (g) |     11.4%        16.0%        33.6%        20.8%       |8.8%         20.6%        14.0%        24.3%        | 
|TERMINAL (d)       |     4/34 (12%)   5/32 (16%)   11/27 (41%)  7/32 (22%)  |4/36 (11%)   8/34 (24%)   4/27 (15%)   9/34 (27%)   | 
|FIRST INCIDENCE    |     603          646          681          593         |730 (T)      677          708          554          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.109      P=0.353      P=0.006 **   P=0.166     |P=0.051      P=0.093      P=0.211      P=0.036 *    | 
|POLY 3             |     P=0.116      P=0.375      P=0.011 *    P=0.180     |P=0.058      P=0.099      P=0.335      P=0.042 *    | 
|POLY 1.5           |     P=0.122      P=0.375      P=0.013 *    P=0.185     |P=0.058      P=0.106      P=0.347      P=0.042 *    | 
|POLY 6             |     P=0.110      P=0.376      P=0.010 *    P=0.176     |P=0.060      P=0.092      P=0.314      P=0.044 *    | 
|LOGISTIC REGRESSION|     P=0.113      P=0.374      P=0.012 *    P=0.180     |P=0.064      P=0.082      P=0.245      P=0.043 *    | 
|COCH-ARM / FISHERS |     P=0.135      P=0.380      P=0.020 *    P=0.194     |P=0.062      P=0.117      P=0.370      P=0.045 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.77      0/43.29      1/41.42      0/42.54     |0/45.31      2/44.41      2/43.65      0/44.68      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.4%         0.0%        |0.0%         4.5%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     687          ---          707          ---         |---          470          557          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.416N     P=0.511N     P=0.741      P=0.517N    |P=0.504N     P=0.232      P=0.235      (e)          | 
|POLY 3             |     P=0.410N     P=0.502N     P=0.749      P=0.506N    |P=0.507N     P=0.233      P=0.229      (e)          | 
|POLY 1.5           |     P=0.408N     P=0.502N     P=0.751      P=0.503N    |P=0.507N     P=0.234      P=0.231      (e)          | 
|POLY 6             |     P=0.411N     P=0.503N     P=0.746      P=0.509N    |P=0.505N     P=0.230      P=0.223      (e)          | 
|LOGISTIC REGRESSION|     P=0.409N     P=0.500N     P=0.754      P=0.500N    |P=0.457N     P=0.303      P=0.278      (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.500N     P=0.753N     P=0.500N    |P=0.500N     P=0.247      P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.60      1/43.29      0/41.34      1/42.54     |0/45.31      0/43.40      1/43.27      1/44.68      | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         0.0%         2.4%        |0.0%         0.0%         2.3%         2.2%         | 
|TERMINAL (d)       |     2/34 (6%)    1/32 (3%)    0/27 (0%)    1/32 (3%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          ---          590          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.388N     P=0.521N     P=0.290N     P=0.521N    |P=0.232      (e)          P=0.491      P=0.489      | 
|POLY 3             |     P=0.372N     P=0.503N     P=0.249N     P=0.509N    |P=0.237      (e)          P=0.491      P=0.497      | 
|POLY 1.5           |     P=0.371N     P=0.502N     P=0.246N     P=0.505N    |P=0.236      (e)          P=0.494      P=0.497      | 
|POLY 6             |     P=0.374N     P=0.503N     P=0.252N     P=0.512N    |P=0.241      (e)          P=0.485      P=0.498      | 
|LOGISTIC REGRESSION|     P=0.388N     P=0.521N     (e)          P=0.521N    |P=0.238      (e)          P=0.555      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.500N     P=0.247N     P=0.500N    |P=0.236      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    2/50 (4%)    4/50 (8%)   |3/50 (6%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/43.68      4/44.64      2/41.98      4/43.41     |3/46.33      3/44.85      1/43.41      0/44.68      | 
|POLY-3 PERCENT (g) |     9.2%         9.0%         4.8%         9.2%        |6.5%         6.7%         2.3%         0.0%         | 
|TERMINAL (d)       |     3/34 (9%)    1/32 (3%)    0/27 (0%)    1/32 (3%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     710          534          527          521         |590          470          535          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.563N     P=0.624      P=0.432N     P=0.616     |P=0.057N     P=0.635      P=0.335N     P=0.128N     | 
|POLY 3             |     P=0.548N     P=0.632N     P=0.355N     P=0.640     |P=0.055N     P=0.647      P=0.329N     P=0.125N     | 
|POLY 1.5           |     P=0.544N     P=0.637N     P=0.352N     P=0.641     |P=0.054N     P=0.653      P=0.320N     P=0.124N     | 
|POLY 6             |     P=0.552N     P=0.623N     P=0.358N     P=0.641     |P=0.057N     P=0.639      P=0.345N     P=0.127N     | 
|LOGISTIC REGRESSION|     P=0.527N     P=0.639N     P=0.349N     P=0.639     |P=0.033N*    P=0.568N     P=0.224N     P=0.090N     | 
|COCH-ARM / FISHERS |     P=0.537N     P=0.643N     P=0.339N     P=0.643N    |P=0.052N     P=0.661N     P=0.309N     P=0.121N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/43.68      3/43.29      1/41.34      2/42.55     |2/45.31      0/43.40      1/42.91      2/45.35      | 
|POLY-3 PERCENT (g) |     4.6%         6.9%         2.4%         4.7%        |4.4%         0.0%         2.3%         4.4%         | 
|TERMINAL (d)       |     1/34 (3%)    3/32 (9%)    1/27 (4%)    1/32 (3%)   |2/36 (6%)    0/34 (0%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     710          729 (T)      729 (T)      728         |730 (T)      ---          703          503          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.525N     P=0.473      P=0.579N     P=0.676     |P=0.461      P=0.251N     P=0.579N     P=0.676      | 
|POLY 3             |     P=0.513N     P=0.496      P=0.519N     P=0.685     |P=0.478      P=0.247N     P=0.519N     P=0.694N     | 
|POLY 1.5           |     P=0.508N     P=0.497      P=0.515N     P=0.688     |P=0.473      P=0.243N     P=0.513N     P=0.692      | 
|POLY 6             |     P=0.518N     P=0.495      P=0.524N     P=0.681     |P=0.485      P=0.252N     P=0.531N     P=0.690N     | 
|LOGISTIC REGRESSION|     P=0.520N     P=0.490      P=0.531N     P=0.681     |P=0.473      (e)          P=0.545N     P=0.682N     | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      P=0.500N     P=0.691N    |P=0.469      P=0.247N     P=0.500N     P=0.691N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.95      0/43.29      0/41.34      1/43.05     |1/45.50      2/43.56      0/42.80      0/44.68      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         2.3%        |2.2%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    1/34 (3%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     632          ---          ---          575         |681          688          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.585      P=0.495N     P=0.505N     P=0.752     |P=0.196N     P=0.464      P=0.536N     P=0.500N     | 
|POLY 3             |     P=0.592      P=0.503N     P=0.512N     P=0.756     |P=0.194N     P=0.485      P=0.512N     P=0.504N     | 
|POLY 1.5           |     P=0.593      P=0.502N     P=0.509N     P=0.758     |P=0.192N     P=0.491      P=0.508N     P=0.503N     | 
|POLY 6             |     P=0.591      P=0.504N     P=0.516N     P=0.754     |P=0.196N     P=0.477      P=0.520N     P=0.503N     | 
|LOGISTIC REGRESSION|     P=0.616      P=0.485N     P=0.474N     P=0.733N    |P=0.190N     P=0.495      P=0.495N     P=0.495N     | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.188N     P=0.500      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.04      1/42.94      2/43.07      0/42.54     |1/45.31      0/43.40      0/42.80      0/44.68      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         4.6%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |1/36 (3%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     603          618          75           ---         |730 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.378N     P=0.760N     P=0.492      P=0.519N    |P=0.320N     P=0.511N     P=0.557N     P=0.511N     | 
|POLY 3             |     P=0.377N     P=0.755      P=0.492      P=0.507N    |P=0.304N     P=0.509N     P=0.511N     P=0.503N     | 
|POLY 1.5           |     P=0.372N     P=0.755      P=0.495      P=0.504N    |P=0.304N     P=0.505N     P=0.507N     P=0.503N     | 
|POLY 6             |     P=0.384N     P=0.756      P=0.489      P=0.510N    |P=0.304N     P=0.513N     P=0.519N     P=0.502N     | 
|LOGISTIC REGRESSION|     P=0.259N     P=0.745N     P=0.673N     P=0.468N    |P=0.320N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.365N     P=0.747      P=0.500      P=0.500N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/49 (8%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    3/50 (6%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/43.60      4/42.69      0/41.34      2/43.05     |1/45.31      3/43.40      1/42.80      3/44.68      | 
|POLY-3 PERCENT (g) |     0.0%         9.4%         0.0%         4.7%        |2.2%         6.9%         2.3%         6.7%         | 
|TERMINAL (d)       |     0/34 (0%)    3/32 (9%)    0/27 (0%)    1/32 (3%)   |1/36 (3%)    3/34 (9%)    1/27 (4%)    3/34 (9%)    | 
|FIRST INCIDENCE    |     ---          695          ---          575         |730 (T)      730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.425      P=0.059      (e)          P=0.231     |P=0.290      P=0.284      P=0.697      P=0.284      | 
|POLY 3             |     P=0.437      P=0.057      (e)          P=0.234     |P=0.306      P=0.290      P=0.748      P=0.300      | 
|POLY 1.5           |     P=0.440      P=0.057      (e)          P=0.235     |P=0.307      P=0.296      P=0.752      P=0.301      | 
|POLY 6             |     P=0.435      P=0.058      (e)          P=0.233     |P=0.307      P=0.282      P=0.740      P=0.302      | 
|LOGISTIC REGRESSION|     P=0.440      P=0.059      (e)          P=0.248     |P=0.290      P=0.284      P=0.697      P=0.284      | 
|COCH-ARM / FISHERS |     P=0.447      P=0.056      (e)          P=0.247     |P=0.313      P=0.309      P=0.753N     P=0.309      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/44.00      1/42.77      3/41.91      1/43.21     |0/45.31      0/43.40      1/42.94      1/44.68      | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         7.2%         2.3%        |0.0%         0.0%         2.3%         2.2%         | 
|TERMINAL (d)       |     1/34 (3%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     617          673          628          506         |---          ---          695          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.494N     P=0.501N     P=0.470      P=0.513N    |P=0.243      (e)          P=0.478      P=0.489      | 
|POLY 3             |     P=0.479N     P=0.510N     P=0.478      P=0.506N    |P=0.237      (e)          P=0.489      P=0.497      | 
|POLY 1.5           |     P=0.476N     P=0.509N     P=0.482      P=0.504N    |P=0.236      (e)          P=0.493      P=0.497      | 
|POLY 6             |     P=0.484N     P=0.510N     P=0.475      P=0.510N    |P=0.241      (e)          P=0.483      P=0.498      | 
|LOGISTIC REGRESSION|     P=0.458N     P=0.503N     P=0.503      P=0.458N    |P=0.237      (e)          P=0.498      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.471N     P=0.508N     P=0.500      P=0.500N    |P=0.236      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchiole                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.89      0/42.55      0/41.34      0/42.54     |0/45.31      0/43.40      0/42.80      0/44.68      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/34 (3%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     651          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.124N     P=0.241N     P=0.268N     P=0.249N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.113N     P=0.244N     P=0.251N     P=0.244N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.114N     P=0.243N     P=0.247N     P=0.241N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.113N     P=0.244N     P=0.254N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.116N     P=0.242N     P=0.242N     P=0.238N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.253N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/0 (0%)     0/1 (0%)     0/3 (0%)    |0/5 (0%)     0/7 (0%)     0/9 (0%)     2/10 (20%)   | 
|POLY-3 RATE (b)    |     0/1.00       0/0.00       0/0.82       0/2.35      |0/4.29       0/6.06       0/7.77       2/9.67       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         20.7%        | 
|TERMINAL (d)       |     0/1 (0%)     0/0 (0%)     0/0 (0%)     0/1 (0%)    |0/3 (0%)     0/5 (0%)     0/4 (0%)     2/7 (29%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.101      (e)          (e)          P=0.435      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.089      (e)          (e)          P=0.429      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.085      (e)          (e)          P=0.418      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.095      (e)          (e)          P=0.435      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.435      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.081      (e)          (e)          P=0.429      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/0 (0%)     0/1 (0%)     2/3 (67%)   |0/5 (0%)     0/7 (0%)     0/9 (0%)     0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/1.00       0/0.00       0/0.82       2/3.00      |0/4.29       0/6.06       0/7.77       0/9.67       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         66.7%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/0 (0%)     0/0 (0%)     0/1 (0%)    |0/3 (0%)     0/5 (0%)     0/4 (0%)     0/7 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          550         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.048 *    (e)          (e)          P=0.231     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.336      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.212      (e)          (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/0 (0%)     0/1 (0%)     0/3 (0%)    |1/5 (20%)    2/7 (29%)    1/9 (11%)    1/10 (10%)   | 
|POLY-3 RATE (b)    |     0/1.00       0/0.00       0/0.82       0/2.35      |1/4.29       2/6.06       1/7.77       1/9.67       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |23.3%        33.0%        12.9%        10.3%        | 
|TERMINAL (d)       |     0/1 (0%)     0/0 (0%)     0/0 (0%)     0/1 (0%)    |1/3 (33%)    2/5 (40%)    1/4 (25%)    1/7 (14%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      730 (T)      730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.277N     P=0.702      P=0.712N     P=0.565N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.281N     P=0.630      P=0.626N     P=0.570N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.630      P=0.623N     P=0.580N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.266N     P=0.620      P=0.642N     P=0.564N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.277N     P=0.702      P=0.712N     P=0.565N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.311N     P=0.636      P=0.604N     P=0.571N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/6 (67%)    5/6 (83%)    5/7 (71%)    5/5 (100%)  |3/4 (75%)    10/15 (67%)  15/21 (71%)  9/11 (82%)   | 
|POLY-3 RATE (b)    |     4/4.94       5/5.47       5/5.93       5/5.00      |3/3.99       10/14.50     15/19.06     9/10.03      | 
|POLY-3 PERCENT (g) |     81.0%        91.4%        84.3%        100.0%      |75.2%        69.0%        78.7%        89.7%        | 
|TERMINAL (d)       |     4/4 (100%)   4/4 (100%)   4/4 (100%)   3/3 (100%)  |3/3 (100%)   7/10 (70%)   8/9 (89%)    5/5 (100%)   | 
|FIRST INCIDENCE    |     729 (T)      398          617          593         |730 (T)      470          535          695          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.147      P=0.500      P=0.500      P=0.229     |P=0.059      P=0.382      P=0.018 *    P=0.067      | 
|POLY 3             |     P=0.339      P=0.698      P=0.776      P=0.532     |P=0.195      P=0.644N     P=0.710      P=0.560      | 
|POLY 1.5           |     P=0.254      P=0.586      P=0.699      P=0.367     |P=0.240      P=0.627N     P=0.739      P=0.601      | 
|POLY 6             |     P=0.583      P=0.933      P=0.903N     P=0.918     |P=0.157      P=0.671N     P=0.658      P=0.522      | 
|LOGISTIC REGRESSION|     P=0.273      P=0.383      P=0.819      P=0.421     |P=0.272      P=0.578N     P=0.642      P=0.315      | 
|COCH-ARM / FISHERS |     P=0.202      P=0.500      P=0.657      P=0.273     |P=0.328      P=0.627N     P=0.758      P=0.637      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/48 (4%)    1/50 (2%)    2/50 (4%)   |0/49 (0%)    1/50 (2%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     3/43.84      2/42.04      1/41.36      2/43.01     |0/44.60      1/43.68      1/43.09      1/43.82      | 
|POLY-3 PERCENT (g) |     6.8%         4.8%         2.4%         4.7%        |0.0%         2.3%         2.3%         2.3%         | 
|TERMINAL (d)       |     1/34 (3%)    2/32 (6%)    0/27 (0%)    1/32 (3%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     687          729 (T)      723          593         |---          653          652          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.430N     P=0.527N     P=0.372N     P=0.525N    |P=0.382      P=0.490      P=0.490      P=0.489      | 
|POLY 3             |     P=0.408N     P=0.519N     P=0.326N     P=0.509N    |P=0.378      P=0.496      P=0.493      P=0.496      | 
|POLY 1.5           |     P=0.405N     P=0.520N     P=0.321N     P=0.505N    |P=0.378      P=0.499      P=0.497      P=0.497      | 
|POLY 6             |     P=0.413N     P=0.518N     P=0.332N     P=0.513N    |P=0.380      P=0.492      P=0.486      P=0.497      | 
|LOGISTIC REGRESSION|     P=0.410N     P=0.513N     P=0.327N     P=0.502N    |P=0.385      P=0.525      P=0.524      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.398N     P=0.520N     P=0.309N     P=0.500N    |P=0.382      P=0.505      P=0.505      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/48 (2%)    2/50 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/43.68      1/42.04      2/41.34      0/42.54     |0/44.60      0/43.40      0/42.80      0/43.82      | 
|POLY-3 PERCENT (g) |     6.9%         2.4%         4.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/34 (6%)    1/32 (3%)    2/27 (7%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     710          729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.120N     P=0.328N     P=0.603N     P=0.132N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.107N     P=0.319N     P=0.525N     P=0.123N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.105N     P=0.320N     P=0.519N     P=0.122N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.109N     P=0.316N     P=0.532N     P=0.125N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.112N     P=0.313N     P=0.549N     P=0.127N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.102N     P=0.324N     P=0.500N     P=0.121N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/49 (4%)    0/50 (0%)    0/48 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/44.32      0/43.40      0/41.15      0/43.78      | 
|POLY-3 PERCENT (g) |                                                        |4.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |                                                        |727          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.130N     P=0.252N     P=0.305N     P=0.252N     | 
|POLY 3             |                                                        |P=0.112N     P=0.242N     P=0.254N     P=0.240N     | 
|POLY 1.5           |                                                        |P=0.113N     P=0.238N     P=0.250N     P=0.240N     | 
|POLY 6             |                                                        |P=0.112N     P=0.246N     P=0.261N     P=0.238N     | 
|LOGISTIC REGRESSION|                                                        |P=0.121N     P=0.252N     P=0.285N     P=0.236N     | 
|COCH-ARM / FISHERS |                                                        |P=0.116N     P=0.242N     P=0.253N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |12/49 (24%)  12/50 (24%)  9/48 (19%)   6/49 (12%)   | 
|POLY-3 RATE (b)    |                                                        |12/45.01     12/44.07     9/41.99      6/44.20      | 
|POLY-3 PERCENT (g) |                                                        |26.7%        27.2%        21.4%        13.6%        | 
|TERMINAL (d)       |                                                        |9/35 (26%)   10/34 (29%)  6/27 (22%)   4/34 (12%)   | 
|FIRST INCIDENCE    |                                                        |590          620          506          634          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.074N     P=0.549      P=0.535N     P=0.112N     | 
|POLY 3             |                                                        |P=0.057N     P=0.571      P=0.375N     P=0.099N     | 
|POLY 1.5           |                                                        |P=0.059N     P=0.588      P=0.360N     P=0.100N     | 
|POLY 6             |                                                        |P=0.054N     P=0.549      P=0.406N     P=0.096N     | 
|LOGISTIC REGRESSION|                                                        |P=0.058N     P=0.564      P=0.373N     P=0.099N     | 
|COCH-ARM / FISHERS |                                                        |P=0.057N     P=0.570N     P=0.331N     P=0.096N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    0/49 (0%)    0/50 (0%)   |0/49 (0%)    2/50 (4%)    0/48 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/43.20      1/42.82      0/40.73      0/42.54     |0/44.60      2/43.40      0/41.17      0/43.78      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         0.0%         0.0%        |0.0%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/34 (3%)    1/32 (3%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    2/34 (6%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.252N     P=0.748      P=0.546N     P=0.512N    |P=0.422N     P=0.226      (e)          (e)          | 
|POLY 3             |     P=0.238N     P=0.759      P=0.512N     P=0.503N    |P=0.420N     P=0.231      (e)          (e)          | 
|POLY 1.5           |     P=0.237N     P=0.759      P=0.509N     P=0.500N    |P=0.416N     P=0.235      (e)          (e)          | 
|POLY 6             |     P=0.240N     P=0.759      P=0.514N     P=0.506N    |P=0.425N     P=0.225      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.252N     P=0.748      (e)          (e)         |(e)          P=0.226      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.233N     P=0.753N     P=0.500N     P=0.495N    |P=0.407N     P=0.253      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)   |0/49 (0%)    2/50 (4%)    0/48 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/43.20      0/42.82      0/40.73      0/42.54     |0/44.60      2/44.27      0/41.17      1/43.78      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.5%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    1/34 (3%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          366          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.524      P=0.233      (e)          P=0.489      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.527      P=0.235      (e)          P=0.496      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.529      P=0.238      (e)          P=0.497      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.525      P=0.231      (e)          P=0.497      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.566      P=0.315      (e)          P=0.489      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.537      P=0.253      (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Penis                                                                                                                            | 
|     Inflammation Acute                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     2/3 (67%)    0/0 (0%)     1/1 (100%)  |                                                    | 
|POLY-3 RATE (b)    |     0/0.00       2/3.00       0/0.00       1/1.00      |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         66.7%        0.0%         100.0%      |                                                    | 
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     ---          646          ---          626         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527      P=0.240      (e)          (e)         |                                                    | 
|POLY 3             |     (e)          (e)          (e)          (e)         |                                                    | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |                                                    | 
|POLY 6             |     (e)          (e)          (e)          (e)         |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.588      P=1.000      (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    2/48 (4%)    2/46 (4%)   |10/47 (21%)  12/49 (24%)  16/49 (33%)  16/48 (33%)  | 
|POLY-3 RATE (b)    |     2/43.28      0/42.55      2/40.08      2/40.39     |10/44.03     12/43.10     16/43.47     16/43.27     | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         5.0%         5.0%        |22.7%        27.8%        36.8%        37.0%        | 
|TERMINAL (d)       |     2/34 (6%)    0/32 (0%)    2/27 (7%)    0/29 (0%)   |9/35 (26%)   10/33 (30%)  12/27 (44%)  14/34 (41%)  | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      575         |530          578          506          639          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.400      P=0.252N     P=0.610      P=0.658     |P=0.076      P=0.345      P=0.035 *    P=0.107      | 
|POLY 3             |     P=0.420      P=0.241N     P=0.666      P=0.669     |P=0.073      P=0.381      P=0.111      P=0.109      | 
|POLY 1.5           |     P=0.421      P=0.240N     P=0.671      P=0.670     |P=0.077      P=0.406      P=0.123      P=0.115      | 
|POLY 6             |     P=0.419      P=0.241N     P=0.663      P=0.668     |P=0.074      P=0.354      P=0.092      P=0.107      | 
|LOGISTIC REGRESSION|     P=0.421      (e)          P=0.610      P=0.689     |P=0.082      P=0.383      P=0.121      P=0.116      | 
|COCH-ARM / FISHERS |     P=0.419      P=0.247N     P=0.684      P=0.667     |P=0.093      P=0.448      P=0.153      P=0.138      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    3/49 (6%)    2/50 (4%)    1/48 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     2/42.95      3/42.47      2/41.81      1/41.73     |                                                    | 
|POLY-3 PERCENT (g) |     4.7%         7.1%         4.8%         2.4%        |                                                    | 
|TERMINAL (d)       |     1/33 (3%)    3/32 (9%)    0/27 (0%)    1/32 (3%)   |                                                    | 
|FIRST INCIDENCE    |     632          729 (T)      650          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.335N     P=0.491      P=0.667      P=0.513N    |                                                    | 
|POLY 3             |     P=0.324N     P=0.495      P=0.685      P=0.510N    |                                                    | 
|POLY 1.5           |     P=0.323N     P=0.496      P=0.688      P=0.509N    |                                                    | 
|POLY 6             |     P=0.326N     P=0.494      P=0.683      P=0.512N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.321N     P=0.499      P=0.685N     P=0.507N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.319N     P=0.500      P=0.684N     P=0.508N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   7/50 (14%)   11/50 (22%)  18/50 (36%) |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     6/43.99      7/44.90      11/42.78     18/46.56    |1/45.39      0/43.40      1/43.41      1/45.24      | 
|POLY-3 PERCENT (g) |     13.6%        15.6%        25.7%        38.7%       |2.2%         0.0%         2.3%         2.2%         | 
|TERMINAL (d)       |     4/34 (12%)   0/32 (0%)    5/27 (19%)   10/32 (31%) |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     644          576          527          365         |708          ---          535          554          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.490      P=0.088      P=0.006 **  |P=0.536      P=0.522N     P=0.737      P=0.758      | 
|POLY 3             |     P<0.001 **   P=0.516      P=0.124      P=0.005 **  |P=0.546      P=0.509N     P=0.751      P=0.760      | 
|POLY 1.5           |     P<0.001 **   P=0.507      P=0.126      P=0.005 **  |P=0.541      P=0.505N     P=0.754      P=0.759      | 
|POLY 6             |     P<0.001 **   P=0.532      P=0.124      P=0.006 **  |P=0.553      P=0.514N     P=0.744      P=0.759N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.501      P=0.122      P=0.006 **  |P=0.571      P=0.507N     P=0.731N     P=0.735N     | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.143      P=0.005 **  |P=0.539      P=0.500N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    3/49 (6%)    3/49 (6%)    2/50 (4%)   |2/49 (4%)    8/50 (16%)   5/48 (10%)   3/47 (6%)    | 
|POLY-3 RATE (b)    |     0/43.20      3/43.13      3/41.71      2/43.46     |2/44.69      8/45.73      5/43.14      3/43.83      | 
|POLY-3 PERCENT (g) |     0.0%         7.0%         7.2%         4.6%        |4.5%         17.5%        11.6%        6.8%         | 
|TERMINAL (d)       |     0/34 (0%)    1/32 (3%)    0/27 (0%)    0/32 (0%)   |1/36 (3%)    3/34 (9%)    1/27 (4%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          683          478          521         |708          470          506          408          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.303      P=0.119      P=0.110      P=0.240     |P=0.489N     P=0.046 *    P=0.166      P=0.490      | 
|POLY 3             |     P=0.312      P=0.118      P=0.112      P=0.238     |P=0.484N     P=0.049 *    P=0.201      P=0.491      | 
|POLY 1.5           |     P=0.315      P=0.118      P=0.113      P=0.240     |P=0.494N     P=0.049 *    P=0.203      P=0.486      | 
|POLY 6             |     P=0.309      P=0.119      P=0.112      P=0.237     |P=0.471N     P=0.048 *    P=0.195      P=0.499      | 
|LOGISTIC REGRESSION|     P=0.339      P=0.119      P=0.142      P=0.289     |P=0.468N     P=0.065      P=0.249      P=0.524      | 
|COCH-ARM / FISHERS |     P=0.321      P=0.121      P=0.121      P=0.253     |P=0.501N     P=0.049 *    P=0.209      P=0.480      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   3/48 (6%)    0/49 (0%)    4/49 (8%)   |2/49 (4%)    2/50 (4%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/44.27      3/43.72      0/40.73      4/43.22     |2/45.22      2/44.69      1/42.51      1/44.68      | 
|POLY-3 PERCENT (g) |     11.3%        6.9%         0.0%         9.3%        |4.4%         4.5%         2.4%         2.2%         | 
|TERMINAL (d)       |     2/34 (6%)    0/32 (0%)    0/27 (0%)    1/32 (3%)   |1/36 (3%)    0/34 (0%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     525          398          ---          593         |530          470          600          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.448N     P=0.368N     P=0.047N*    P=0.531N    |P=0.354N     P=0.683      P=0.536N     P=0.518N     | 
|POLY 3             |     P=0.434N     P=0.363N     P=0.038N*    P=0.515N    |P=0.343N     P=0.690      P=0.522N     P=0.504N     | 
|POLY 1.5           |     P=0.428N     P=0.365N     P=0.036N*    P=0.510N    |P=0.341N     P=0.693N     P=0.514N     P=0.501N     | 
|POLY 6             |     P=0.440N     P=0.361N     P=0.040N*    P=0.520N    |P=0.345N     P=0.683      P=0.534N     P=0.506N     | 
|LOGISTIC REGRESSION|     P=0.380N     P=0.302N     P=0.028N*    P=0.468N    |P=0.289N     P=0.587N     P=0.435N     P=0.470N     | 
|COCH-ARM / FISHERS |     P=0.417N     P=0.369N     P=0.028N*    P=0.500N    |P=0.333N     P=0.684N     P=0.500N     P=0.492N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   1/48 (2%)    0/49 (0%)    2/49 (4%)   |0/49 (0%)    2/50 (4%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/44.04      1/42.87      0/40.73      2/42.30     |0/44.60      2/44.69      1/42.51      0/44.68      | 
|POLY-3 PERCENT (g) |     11.4%        2.3%         0.0%         4.7%        |0.0%         4.5%         2.4%         0.0%         | 
|TERMINAL (d)       |     2/34 (6%)    0/32 (0%)    0/27 (0%)    1/32 (3%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     617          398          ---          681         |---          470          600          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.186N     P=0.114N     P=0.047N*    P=0.248N    |P=0.467N     P=0.237      P=0.496      (e)          | 
|POLY 3             |     P=0.167N     P=0.107N     P=0.037N*    P=0.232N    |P=0.466N     P=0.237      P=0.490      (e)          | 
|POLY 1.5           |     P=0.165N     P=0.107N     P=0.035N*    P=0.226N    |P=0.464N     P=0.239      P=0.493      (e)          | 
|POLY 6             |     P=0.170N     P=0.108N     P=0.040N*    P=0.241N    |P=0.468N     P=0.235      P=0.484      (e)          | 
|LOGISTIC REGRESSION|     P=0.151N     P=0.086N     P=0.033N*    P=0.216N    |P=0.401N     P=0.332      P=0.549      (e)          | 
|COCH-ARM / FISHERS |     P=0.163N     P=0.107N     P=0.028N*    P=0.218N    |P=0.457N     P=0.253      P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    1/48 (2%)    0/49 (0%)    2/49 (4%)   |1/49 (2%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.73      1/42.87      0/40.73      2/42.30     |1/44.79      0/43.40      1/42.35      0/44.68      | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         0.0%         4.7%        |2.2%         0.0%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    1/32 (3%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     617          398          ---          681         |683          ---          652          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570      P=0.503N     P=0.248N     P=0.667     |P=0.401N     P=0.526N     P=0.737      P=0.495N     | 
|POLY 3             |     P=0.581      P=0.507N     P=0.253N     P=0.682     |P=0.400N     P=0.506N     P=0.748      P=0.500N     | 
|POLY 1.5           |     P=0.585      P=0.507N     P=0.249N     P=0.687     |P=0.402N     P=0.502N     P=0.752      P=0.500N     | 
|POLY 6             |     P=0.576      P=0.508N     P=0.258N     P=0.677     |P=0.397N     P=0.512N     P=0.740      P=0.501N     | 
|LOGISTIC REGRESSION|     P=0.617      P=0.416N     P=0.218N     P=0.691N    |P=0.396N     P=0.490N     P=0.753N     P=0.491N     | 
|COCH-ARM / FISHERS |     P=0.593      P=0.508N     P=0.247N     P=0.691N    |P=0.402N     P=0.495N     P=0.753N     P=0.495N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/44 (2%)    0/49 (0%)    0/48 (0%)   |0/47 (0%)    1/49 (2%)    1/47 (2%)    1/47 (2%)    | 
|POLY-3 RATE (b)    |     2/42.48      1/39.16      0/40.73      0/41.12     |0/43.64      1/43.18      1/40.55      1/42.82      | 
|POLY-3 PERCENT (g) |     4.7%         2.6%         0.0%         0.0%        |0.0%         2.3%         2.5%         2.3%         | 
|TERMINAL (d)       |     2/34 (6%)    1/32 (3%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    1/27 (4%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          653          730 (T)      709          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.114N     P=0.521N     P=0.290N     P=0.252N    |P=0.383      P=0.490      P=0.443      P=0.500      | 
|POLY 3             |     P=0.101N     P=0.528N     P=0.246N     P=0.244N    |P=0.376      P=0.498      P=0.485      P=0.496      | 
|POLY 1.5           |     P=0.100N     P=0.530N     P=0.243N     P=0.241N    |P=0.376      P=0.502      P=0.490      P=0.497      | 
|POLY 6             |     P=0.103N     P=0.524N     P=0.250N     P=0.248N    |P=0.379      P=0.494      P=0.478      P=0.497      | 
|LOGISTIC REGRESSION|     P=0.114N     P=0.521N     (e)          (e)         |P=0.379      P=0.548      P=0.443      P=0.498      | 
|COCH-ARM / FISHERS |     P=0.098N     P=0.533N     P=0.242N     P=0.247N    |P=0.380      P=0.510      P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    0/44 (0%)    1/49 (2%)    1/48 (2%)   |0/47 (0%)    1/49 (2%)    1/47 (2%)    3/47 (6%)    | 
|POLY-3 RATE (b)    |     2/42.72      0/39.16      1/41.09      1/41.43     |0/43.64      1/43.29      1/40.90      3/44.58      | 
|POLY-3 PERCENT (g) |     4.7%         0.0%         2.4%         2.4%        |0.0%         2.3%         2.5%         6.7%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     687          ---          628          645         |---          620          634          408          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.516N     P=0.252N     P=0.535N     P=0.513N    |P=0.059      P=0.495      P=0.495      P=0.124      | 
|POLY 3             |     P=0.499N     P=0.256N     P=0.514N     P=0.511N    |P=0.055      P=0.498      P=0.487      P=0.122      | 
|POLY 1.5           |     P=0.495N     P=0.257N     P=0.508N     P=0.506N    |P=0.053      P=0.502      P=0.491      P=0.120      | 
|POLY 6             |     P=0.503N     P=0.254N     P=0.519N     P=0.516N    |P=0.057      P=0.494      P=0.481      P=0.126      | 
|LOGISTIC REGRESSION|     P=0.484N     P=0.257N     P=0.487N     P=0.495N    |P=0.058      P=0.581      P=0.539      P=0.239      | 
|COCH-ARM / FISHERS |     P=0.491N     P=0.269N     P=0.492N     P=0.500N    |P=0.052      P=0.510      P=0.500      P=0.121      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     2/43.60      1/43.68      1/41.34      2/42.54     |                                                    | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         2.4%         4.7%        |                                                    | 
|TERMINAL (d)       |     2/34 (6%)    0/32 (0%)    1/27 (4%)    2/32 (6%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      618          729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.530      P=0.511N     P=0.581N     P=0.674     |                                                    | 
|POLY 3             |     P=0.545      P=0.499N     P=0.519N     P=0.685     |                                                    | 
|POLY 1.5           |     P=0.549      P=0.500N     P=0.514N     P=0.688     |                                                    | 
|POLY 6             |     P=0.539      P=0.497N     P=0.523N     P=0.682     |                                                    | 
|LOGISTIC REGRESSION|     P=0.543      P=0.501N     P=0.581N     P=0.674     |                                                    | 
|COCH-ARM / FISHERS |     P=0.556      P=0.500N     P=0.500N     P=0.691N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/43.60      0/43.29      0/41.34      0/42.54     |                                                    | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     2/34 (6%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.127N     P=0.252N     P=0.290N     P=0.252N    |                                                    | 
|POLY 3             |     P=0.114N     P=0.239N     P=0.249N     P=0.242N    |                                                    | 
|POLY 1.5           |     P=0.114N     P=0.238N     P=0.246N     P=0.241N    |                                                    | 
|POLY 6             |     P=0.114N     P=0.238N     P=0.252N     P=0.245N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.127N     (e)          (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/41 (0%)    0/39 (0%)    0/40 (0%)    0/42 (0%)   |0/43 (0%)    0/45 (0%)    2/47 (4%)    0/46 (0%)    | 
|POLY-3 RATE (b)    |     0/36.75      0/33.90      0/34.05      0/37.66     |0/39.89      0/40.31      2/41.52      0/41.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.8%         0.0%         | 
|TERMINAL (d)       |     0/30 (0%)    0/28 (0%)    0/24 (0%)    0/30 (0%)   |0/34 (0%)    0/33 (0%)    0/26 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          15           ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.595      (e)          P=0.237      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.605      (e)          P=0.246      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.603      (e)          P=0.251      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.612      (e)          P=0.237      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.677N     (e)          P=0.539      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.608      (e)          P=0.270      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    2/48 (4%)    3/47 (6%)    2/50 (4%)   |0/50 (0%)    2/49 (4%)    1/47 (2%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     3/43.20      2/42.00      3/38.85      2/42.54     |0/45.31      2/42.95      1/40.23      3/43.47      | 
|POLY-3 PERCENT (g) |     7.0%         4.8%         7.7%         4.7%        |0.0%         4.7%         2.5%         6.9%         | 
|TERMINAL (d)       |     3/34 (9%)    1/31 (3%)    3/26 (12%)   2/32 (6%)   |0/36 (0%)    2/34 (6%)    1/27 (4%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      673          729 (T)      729 (T)     |---          730 (T)      730 (T)      708          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.489N     P=0.529N     P=0.534      P=0.528N    |P=0.101      P=0.226      P=0.443      P=0.116      | 
|POLY 3             |     P=0.464N     P=0.513N     P=0.613      P=0.507N    |P=0.096      P=0.225      P=0.476      P=0.111      | 
|POLY 1.5           |     P=0.457N     P=0.513N     P=0.620      P=0.501N    |P=0.096      P=0.228      P=0.480      P=0.110      | 
|POLY 6             |     P=0.473N     P=0.512N     P=0.607      P=0.514N    |P=0.099      P=0.222      P=0.470      P=0.113      | 
|LOGISTIC REGRESSION|     P=0.477N     P=0.517N     P=0.534      P=0.528N    |P=0.108      P=0.226      P=0.443      P=0.115      | 
|COCH-ARM / FISHERS |     P=0.446N     P=0.510N     P=0.641      P=0.490N    |P=0.097      P=0.242      P=0.485      P=0.114      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/46 (0%)    1/49 (2%)    2/50 (4%)   |0/48 (0%)    0/50 (0%)    0/49 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/43.27      0/40.78      1/41.35      2/43.49     |0/44.22      0/43.40      0/42.07      0/43.52      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.4%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     710          ---          527          521         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.247      P=0.512N     P=0.728      P=0.497     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.255      P=0.512N     P=0.751      P=0.502     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.257      P=0.513N     P=0.752      P=0.504     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.252      P=0.510N     P=0.749      P=0.500     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.277      P=0.511N     P=0.730N     P=0.556     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.259      P=0.516N     P=0.753N     P=0.508     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/49 (10%)   3/50 (6%)    9/49 (18%)   8/49 (16%)   | 
|POLY-3 RATE (b)    |                                                        |5/44.70      3/43.73      9/42.44      8/45.02      | 
|POLY-3 PERCENT (g) |                                                        |11.2%        6.9%         21.2%        17.8%        | 
|TERMINAL (d)       |                                                        |3/36 (8%)    2/34 (6%)    6/27 (22%)   4/34 (12%)   | 
|FIRST INCIDENCE    |                                                        |708          637          675          503          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.116      P=0.395N     P=0.086      P=0.266      | 
|POLY 3             |                                                        |P=0.120      P=0.368N     P=0.162      P=0.280      | 
|POLY 1.5           |                                                        |P=0.114      P=0.359N     P=0.173      P=0.275      | 
|POLY 6             |                                                        |P=0.131      P=0.380N     P=0.146      P=0.290      | 
|LOGISTIC REGRESSION|                                                        |P=0.110      P=0.377N     P=0.127      P=0.274      | 
|COCH-ARM / FISHERS |                                                        |P=0.113      P=0.346N     P=0.194      P=0.276      | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.