National Toxicology Program

National Toxicology Program
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TDMS Study 96001-06 Pathology Tables

NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23

                                                         FINAL #1 MICE




       Facility:  Battelle Northwest

       Chemical CAS #:  64742-88-7

       Lock Date:  09/25/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6           11           11           10                                     
    Natural Death                                      8            5           12            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           34           27           34                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (43)         (45)         (44)         (47)                                   
      Infiltration Cellular, Plasma Cell                                         1 [3.0]                                            
   Intestine Small, Jejunum                           (43)         (47)         (43)         (47)                                   
      Necrosis                                                                   1 [3.0]                                            
   Intestine Small, Ileum                             (43)         (47)         (44)         (46)                                   
      Inflammation                                                                            1 [3.0]                               
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 [2.0]      1 [2.0]                                                         
      Basophilic Focus                                 4 [2.3]      5 [2.6]      8 [2.1]      4 [3.0]                               
      Clear Cell Focus                                 4 [1.5]                   2 [2.0]      2 [2.5]                               
      Eosinophilic Focus                               4 [2.3]      9 [2.5]      6 [2.5]     11 [2.2]                               
      Fatty Change                                                  2 [2.5]      2 [2.5]                                            
      Hematopoietic Cell Proliferation                              1 [4.0]                                                         
      Infarct                                          1 [4.0]                                                                      
      Inflammation, Granulomatous                                   1 [2.0]                                                         
      Inflammation, Suppurative                                                               1 [2.0]                               
      Mixed Cell Focus                                                           1 [2.0]      1 [3.0]                               
      Necrosis                                         3 [2.0]      3 [2.3]      1 [2.0]                                            
      Parasite Metazoan                                             1 [2.0]                                                         
      Tension Lipidosis                                2 [1.5]                   1 [2.0]      2 [2.0]                               
      Centrilobular, Necrosis                          1 [1.0]      2 [2.0]                                                         
   Mesentery                                          (4)          (15)         (21)         (11)                                   
      Artery, Mineralization                                        1 [3.0]                                                         
      Fat, Hemorrhage                                               1 [1.0]      1 [2.0]      1 [2.0]                               
      Fat, Necrosis                                    3 [2.3]     10 [2.3]     15 [2.0]      9 [2.0]                               
   Pancreas                                           (49)         (50)         (48)         (49)                                   
      Atrophy                                                       2 [1.0]                                                         
      Atypia Cellular                                  1 [1.0]                                                                      
      Inflammation, Suppurative                                                               1 [3.0]                               
      Lipomatosis                                                                1 [4.0]      1 [3.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Hypertrophy                                                                     1 [1.0]                               
      Duct, Cyst                                                    2 [3.5]                   1 [4.0]                               
   Salivary Glands                                    (50)         (49)         (49)         (50)                                   
      Atrophy                                                       1 [2.0]      1 [2.0]                                            
   Stomach, Forestomach                               (49)         (50)         (49)         (50)                                   
      Hyperplasia, Squamous                            2 [2.5]      2 [1.0]      1 [1.0]      1 [3.0]                               
      Inflammation, Chronic Active                                  2 [1.5]      1 [1.0]                                            
      Ulcer                                            1 [3.0]                   1 [1.0]                                            
   Stomach, Glandular                                 (47)         (49)         (47)         (47)                                   
      Amyloid Deposition                                                         1 [2.0]                                            
      Mineralization                                                1 [1.0]      1 [1.0]      1 [2.0]                               
      Necrosis                                                      1 [1.0]      1 [1.0]      3 [1.7]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (2)                                    
      Aorta, Mineralization                            1 [3.0]                                2 [2.0]                               
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   6 [1.2]      6 [1.0]      6 [1.0]      9 [1.2]                               
      Mineralization                                   3 [1.3]      4 [1.3]                   4 [1.5]                               
      Thrombosis                                       2 [2.0]                                                                      
      Artery, Inflammation                             1 [1.0]                   1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                              1 [4.0]                                                         
      Hyperplasia                                      4 [1.5]      3 [1.7]      3 [2.0]      6 [2.0]                               
      Hypertrophy                                      2 [1.5]      3 [1.7]      2 [1.0]      3 [2.0]                               
      Necrosis                                                                   1 [2.0]                                            
      Vacuolization Cytoplasmic                        1 [4.0]                                                                      
   Adrenal Medulla                                    (49)         (50)         (48)         (49)                                   
      Hyperplasia                                      2 [2.0]      3 [2.3]      4 [2.5]      2 [1.5]                               
   Islets, Pancreatic                                 (49)         (50)         (48)         (48)                                   
      Hyperplasia                                      1 [2.0]      1 [3.0]                                                         
   Pituitary Gland                                    (47)         (49)         (49)         (48)                                   
      Angiectasis                                      1 [2.0]                                                                      
      Pars Distalis, Hyperplasia                      10 [1.7]     12 [1.5]     16 [1.7]     16 [2.5]                               
      Pars Intermedia, Hypertrophy                                               1 [1.0]                                            
   Thyroid Gland                                      (50)         (49)         (47)         (48)                                   
      Inflammation, Chronic                            1 [1.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia                                  2 [2.0]      1 [1.0]      3 [1.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                                                              
      Inflammation, Acute                                           1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (40)         (42)         (47)         (41)                                   
      Fibrosis                                                      1 [3.0]                                                         
   Ovary                                              (49)         (50)         (48)         (49)                                   
      Angiectasis                                      2 [4.0]                                                                      
      Cyst                                            12 [2.6]     12 [2.3]      9 [2.2]      6 [2.3]                               
   Uterus                                             (49)         (50)         (49)         (49)                                   
      Angiectasis                                      1 [3.0]                                                                      
      Inflammation, Suppurative                                                               1 [2.0]                               
      Endometrium, Hyperplasia, Cystic                 5 [4.0]      3 [2.3]      9 [3.0]      8 [3.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (48)         (50)                                   
      Atrophy                                                       1 [2.0]      1 [2.0]                                            
      Cytoplasmic Alteration, Focal                                 1 [2.0]                                                         
      Hyperplasia                                                                             1 [3.0]                               
   Lymph Node                                         (5)          (7)          (9)          (10)                                   
      Angiectasis                                                                             1 [3.0]                               
      Iliac, Angiectasis                                                                      2 [2.5]                               
      Renal, Angiectasis                               1 [4.0]      2 [3.0]      1 [4.0]      1 [2.0]                               
      Renal, Ectasia                                                             1 [2.0]                                            
   Lymph Node, Mandibular                             (42)         (32)         (40)         (40)                                   
      Infiltration Cellular, Plasma Cell                                                      1 [3.0]                               
   Lymph Node, Mesenteric                             (47)         (49)         (47)         (50)                                   
      Angiectasis                                                   1 [3.0]                   1 [3.0]                               
   Lymph Node, Mediastinal                            (40)         (42)         (43)         (43)                                   
      Infiltration Cellular, Polymorphonuclear                      1 [3.0]                                                         
   Spleen                                             (49)         (50)         (48)         (47)                                   
      Angiectasis                                                                1 [2.0]      1 [4.0]                               
      Congestion                                                    1 [3.0]                                                         
      Hematopoietic Cell Proliferation                 2 [3.0]      8 [2.6]      5 [2.8]      3 [3.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 [4.0]      1 [2.0]                   1 [2.0]                               
      Necrosis                                         1 [4.0]                                                                      
   Thymus                                             (43)         (45)         (47)         (46)                                   
      Atrophy                                                                    2 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Mixed Cell                1 [1.0]                   1 [2.0]                                            
      Inflammation, Chronic Active                     1 [4.0]                   1 [1.0]      1 [3.0]                               
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
          Inclusion                                    1 [2.0]                                                                      
      Subcutaneous Tissue, Edema                                    1 [2.0]                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fracture                                                      1            1                                                  
   Skeletal Muscle                                    (1)          (1)          (1)          (2)                                    
      Hemorrhage                                                    1 [3.0]                                                         
      Inflammation, Suppurative                                                               1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                                   1 [4.0]                                                         
      Necrosis                                                      1 [2.0]      1 [2.0]                                            
      Artery, Inflammation                             1 [1.0]                                                                      
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         6 [1.2]      2 [1.5]      2 [1.5]      3 [1.3]                               
   Peripheral Nerve                                                             (1)          (1)                                    
      Inflammation, Suppurative                                                               1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Artery, Inflammation                                                       1 [2.0]                                            
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 [1.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 1 [1.0]      3 [2.3]      1 [1.0]      3 [1.3]                               
      Alveolus, Infiltration Cellular, Histiocyte                                1 [1.0]      1 [1.0]                               
   Nose                                               (49)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                                     1 [2.0]      1 [2.0]      1 [2.0]                               
      Respiratory Epithelium, Degeneration                          1 [2.0]                                                         
   Trachea                                            (49)         (50)         (49)         (47)                                   
      Artery, Inflammation                             1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (46)         (49)         (45)         (46)                                   
      Cataract                                         1 [3.0]      2 [2.0]      2 [2.0]                                            
      Inflammation, Chronic                            1 [3.0]                                                                      
      Cornea, Inflammation, Chronic Active                          1 [3.0]      1 [1.0]      2 [2.0]                               
   Harderian Gland                                    (49)         (49)         (49)         (49)                                   
      Hyperplasia                                      4 [2.0]      3 [2.0]      4 [2.3]      7 [1.7]                               
      Infiltration Cellular                                                      1 [2.0]                                            
      Inflammation, Granulomatous                      1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (49)                                   
      Amyloid Deposition                                            1 [3.0]                                                         
      Cyst                                             1 [2.0]                                                                      
      Infarct                                          1 [3.0]                                                                      
      Inflammation, Suppurative                                                               1 [4.0]                               
      Metaplasia, Osseous                                           2 [1.0]      1 [1.0]      2 [2.5]                               
      Mineralization                                   1 [2.0]      1 [2.0]                   2 [1.0]                               
      Nephropathy                                     39 [1.1]     32 [1.3]     33 [1.0]     40 [1.1]                               
      Capsule, Fibrosis                                1 [2.0]                                                                      
      Papilla, Necrosis                                                                       1 [3.0]                               
      Pelvis, Dilatation                                            1 [2.0]                                                         
      Renal Tubule, Karyomegaly                                     1 [1.0]                                                         
      Renal Tubule, Necrosis                                                                  1 [2.0]                               
   Urinary Bladder                                    (48)         (50)         (49)         (48)                                   
      Inflammation, Suppurative                                                               1 [2.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            9           16           13                                     
    Natural Death                                      9            9            6            5                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32           27           32                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (39)         (36)         (41)         (43)                                   
      Degeneration, Hyaline                                         1 [2.0]                                                         
      Hyperplasia                                      1 [2.0]                                                                      
      Infiltration Cellular, Mixed Cell                1 [2.0]                                                                      
      Inflammation, Chronic Active                                  1 [3.0]                                                         
   Intestine Large, Cecum                             (45)         (41)         (46)         (47)                                   
      Hemorrhage                                       1 [4.0]                                1 [2.0]                               
   Intestine Small, Duodenum                          (46)         (41)         (46)         (47)                                   
      Inflammation, Chronic Active                                               1 [4.0]                                            
   Intestine Small, Jejunum                           (46)         (41)         (46)         (47)                                   
      Serosa, Inflammation, Granulomatous              1 [3.0]                                                                      
   Intestine Small, Ileum                             (45)         (41)         (46)         (47)                                   
      Infiltration Cellular, Plasma Cell                                         1 [2.0]                                            
      Inflammation                                                  1 [3.0]                                                         
   Liver                                              (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 [3.0]                                                                      
      Basophilic Focus                                 9 [2.3]     13 [2.3]     17 [2.4]     11 [2.5]                               
      Clear Cell Focus                                13 [1.9]     11 [2.0]     15 [2.1]     10 [2.3]                               
      Eosinophilic Focus                               5 [1.8]      7 [2.1]     14 [2.2]      9 [1.9]                               
      Fatty Change                                     1 [2.0]                   1 [2.0]                                            
      Infarct                                          1 [2.0]                                1 [4.0]                               
      Inflammation, Chronic                                                                   1 [2.0]                               
      Mitotic Alteration                                            1 [3.0]                                                         
      Mixed Cell Focus                                 2 [0.0]      1 [2.0]                   1 [2.0]                               
      Necrosis                                         4 [1.5]      4 [2.3]      2 [2.0]      4 [2.0]                               
      Tension Lipidosis                                2 [1.0]      3 [1.3]      1 [2.0]      2 [1.5]                               
      Bile Duct, Cyst                                                                         1 [2.0]                               
      Centrilobular, Necrosis                          1 [2.0]                                1 [3.0]                               
   Mesentery                                          (6)          (6)          (7)          (5)                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation                             1 [3.0]                   1 [3.0]                                            
      Fat, Hemorrhage                                               1 [3.0]                                                         
      Fat, Necrosis                                    4 [1.8]      5 [2.0]      5 [2.2]      5 [2.2]                               
   Pancreas                                           (49)         (49)         (49)         (50)                                   
      Atrophy                                          1 [1.0]      1 [1.0]                                                         
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
      Atrophy                                                                    1 [2.0]                                            
   Stomach, Forestomach                               (49)         (48)         (49)         (49)                                   
      Hyperplasia, Squamous                            5 [2.2]      3 [2.3]                   4 [1.8]                               
      Inflammation, Chronic Active                     5 [1.6]      1 [3.0]                   2 [2.5]                               
      Ulcer                                            2 [2.0]      1 [2.0]                   2 [2.5]                               
   Stomach, Glandular                                 (48)         (44)         (49)         (48)                                   
      Degeneration, Hyaline                                                                   1 [2.0]                               
      Hyperplasia                                                   1 [2.0]                                                         
      Mineralization                                   2 [1.0]      1 [1.0]                                                         
      Necrosis                                         2 [1.5]                   1 [3.0]      1 [1.0]                               
      Vacuolization Cytoplasmic                                                  1 [2.0]                                            
   Tongue                                                                                    (1)                                    
      Mineralization                                                                          1 [1.0]                               
   Tooth                                              (19)         (16)         (21)         (17)                                   
      Malformation                                                                            1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)          (1)                                    
      Aorta, Mineralization                                                      1 [3.0]                                            
   Heart                                              (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 [1.0]                                                                      
      Angiectasis                                                   1 [2.0]                                                         
      Cardiomyopathy                                  15 [1.3]     12 [1.1]     21 [1.2]     19 [1.1]                               
      Infiltration Cellular, Polymorphonuclear                                   1 [2.0]                                            
      Mineralization                                   1 [2.0]      2 [1.0]      2 [1.0]      1 [1.0]                               
      Thrombosis                                                    1 [4.0]      1 [3.0]      1 [3.0]                               
      Artery, Inflammation                                                       1 [3.0]                                            
      Capillary, Endothelium, Hyperplasia                           1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (49)         (50)                                   
      Atrophy                                                                    1 [2.0]                                            
      Hyperplasia                                     13 [2.0]     10 [1.8]      7 [2.0]     15 [1.6]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hypertrophy                                     30 [1.7]     29 [1.7]     20 [1.8]     20 [1.9]                               
   Adrenal Medulla                                    (48)         (49)         (49)         (50)                                   
      Hyperplasia                                      3 [1.7]      4 [2.3]      3 [1.7]      1 [1.0]                               
   Islets, Pancreatic                                 (48)         (49)         (49)         (50)                                   
      Hyperplasia                                                   1 [2.0]      1 [2.0]                                            
   Pituitary Gland                                    (49)         (49)         (48)         (46)                                   
      Pars Distalis, Hyperplasia                       2 [1.5]                   2 [2.0]      2 [1.5]                               
      Pars Intermedia, Hyperplasia                                                            1 [2.0]                               
   Thyroid Gland                                      (49)         (48)         (47)         (50)                                   
      Follicular Cell, Hyperplasia                     3 [1.0]      2 [1.0]      3 [1.0]      2 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)          (1)          (1)                                                 
      Inflammation, Suppurative                        1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                            (2)                                                 
      Hyperplasia                                                                1 [2.0]                                            
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  3 [2.0]                   3 [1.7]      2 [2.0]                               
      Infiltration Cellular, Mononuclear Cell                                                 1 [3.0]                               
   Penis                                                           (3)                       (1)                                    
      Inflammation, Acute                                           2 [3.5]                   1 [2.0]                               
   Preputial Gland                                    (49)         (49)         (50)         (48)                                   
      Ectasia                                          1 [2.0]                                                                      
      Inflammation, Chronic Active                     2 [2.5]      3 [2.0]      2 [3.0]      1 [4.0]                               
   Prostate                                           (46)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 [2.0]      1 [2.0]                   1 [3.0]                               
      Artery, Inflammation                                                       1 [3.0]                                            
   Seminal Vesicle                                    (48)         (46)         (50)         (48)                                   
      Amyloid Deposition                                                                      1 [3.0]                               
      Infiltration Cellular, Mononuclear Cell                       1 [2.0]                                                         
      Inflammation, Chronic                                         1 [2.0]                                                         
      Inflammation, Suppurative                                     1 [3.0]                                                         
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 [2.0]      1 [4.0]      1 [2.0]      2 [3.0]                               
      Mineralization                                                1 [4.0]                                                         
      Germinal Epithelium, Degeneration                1 [2.0]                                                                      
      Interstitial Cell, Hyperplasia                   2 [3.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (1)                       (1)          (3)                                    
      Deep Cervical, Hyperplasia, Lymphoid                                                    1 [3.0]                               
      Lumbar, Infiltration Cellular, Plasma Cell                                              2 [2.0]                               
   Lymph Node, Mesenteric                             (48)         (46)         (48)         (48)                                   
      Angiectasis                                                                1 [3.0]                                            
      Hyperplasia, Lymphoid                                                                   1 [3.0]                               
      Infiltration Cellular, Plasma Cell                                         1 [4.0]                                            
   Lymph Node, Mediastinal                            (39)         (40)         (36)         (43)                                   
      Infiltration Cellular, Plasma Cell                                                      1 [2.0]                               
   Spleen                                             (49)         (49)         (49)         (50)                                   
      Amyloid Deposition                               1 [3.0]                                                                      
      Angiectasis                                                                1 [2.0]                                            
      Hematopoietic Cell Proliferation                              3 [3.0]      3 [3.3]      2 [3.5]                               
   Thymus                                             (41)         (39)         (40)         (42)                                   
      Cyst                                             1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1 [3.0]                                                                      
      Infiltration Cellular, Mixed Cell                1 [1.0]                                                                      
      Inflammation, Chronic Active                     6 [3.0]      7 [3.4]     11 [3.3]     18 [3.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Intervertebral Disc, Necrosis                                              1 [2.0]                                            
   Skeletal Muscle                                                                           (1)                                    
      Inflammation, Suppurative                                                               1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                                                1 [2.0]                                            
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                                                   1 [2.0]                                            
   Spinal Cord                                                                               (1)                                    
      Degeneration                                                                            1 [3.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (50)                                   
      Fibrosis                                                                   1 [3.0]                                            
      Hemorrhage                                       1 [1.0]      1 [2.0]      2 [2.0]                                            
      Inflammation, Chronic Active                                                            1 [1.0]                               
      Thrombosis                                       1 [1.0]                   1 [1.0]                                            
      Alveolar Epithelium, Hyperplasia                              4 [1.8]                   2 [3.0]                               
      Alveolus, Infiltration Cellular, Histiocyte      2 [1.5]      1 [2.0]      3 [2.0]      1 [4.0]                               
      Bronchiole, Hyperplasia                          2 [1.0]                                                                      
      Mediastinum, Thrombosis                                       1 [2.0]                                                         
   Nose                                               (50)         (48)         (50)         (50)                                   
      Inflammation, Suppurative                        3 [2.3]      2 [1.5]      1 [2.0]      2 [2.5]                               
      Polyp, Inflammatory                              1 [3.0]                   1 [3.0]                                            
      Olfactory Epithelium, Atrophy                    3 [2.3]      1 [2.0]      2 [2.0]                                            
      Olfactory Epithelium, Inflammation,                                                                                           
          Granulomatous                                                          1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (46)         (46)         (47)         (46)                                   
      Cornea, Inflammation, Chronic Active                          3 [2.0]      1 [2.0]      1 [4.0]                               
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia                                      3 [2.3]      4 [2.5]      1 [3.0]      1 [3.0]                               
   Zymbal's Gland                                     (1)                                    (1)                                    
      Cyst                                             1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Amyloid Deposition                               1 [4.0]                                                                      
      Cyst                                             3 [2.0]      1 [1.0]      3 [1.7]      1 [2.0]                               
      Inflammation, Granulomatous                                                1 [2.0]                                            
      Inflammation, Suppurative                        1 [2.0]                   2 [2.5]      2 [3.0]                               
      Metaplasia, Osseous                              3 [1.0]      4 [1.5]                   2 [1.5]                               
      Nephropathy                                     44 [1.4]     43 [1.5]     42 [1.4]     44 [1.3]                               
      Capsule, Fibrosis                                1 [2.0]                                1 [2.0]                               
      Papilla, Necrosis                                             1 [4.0]      1 [4.0]                                            
      Pelvis, Dilatation                                            1 [3.0]                   2 [2.0]                               
      Renal Tubule, Hyperplasia                        2 [1.0]      1 [2.0]                                                         
      Renal Tubule, Necrosis                                        2 [2.5]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/25/02    
Route: RESPIRATORY EXPOSURE WHOLE BODY                   STODDARD SOLVENT (TYPE IIC)                              Time: 11:16:23    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      550          1100         2200                                   
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                                       1 [2.0]      2 [1.0]                               
   Urinary Bladder                                    (49)         (46)         (49)         (50)                                   
      Infiltration Cellular, Mixed Cell                             1 [2.0]      1 [3.0]                                            
      Inflammation, Acute                                                        1 [2.0]                                            
      Inflammation, Chronic Active                     1 [4.0]                   1 [4.0]      2 [3.0]                               
      Transitional Epithelium, Hyperplasia             1 [2.0]                   1 [3.0]      1 [3.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.