TDMS Study 96002-01 Pathology Tables
NTP Experiment-Test: 96002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:17:07
FINAL #1; 17 DAY REPEATED DOSE
Facility: BIORELIANCE
Chemical CAS #: 136-35-6
Lock Date: 01/21/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:17:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 12.5 25 MG/KG 50 MG/KG 100 200
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 5 5 5 5 5 5
Early Deaths
Survivors
Terminal Sacrifice 5 5 5 5 5 5
Animals Examined Microscopically 5 5 5 5 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (5) (5) (5) (5) (5) (5)
Hematopoietic Cell Proliferation 1 (20%) 2 (40%)
Hepatodiaphragmatic Nodule 1 (20%) 1 (20%) 1 (20%) 1 (20%)
Inflammation, Focal 1 (20%) 3 (60%) 1 (20%)
Pancreas (5) (5)
Infiltration Cellular, Focal, Lymphocyte 3 (60%) 4 (80%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (2) (1) (1)
Bronchial, Hemorrhage 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:17:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 12.5 25 MG/KG 50 MG/KG 100 200
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Bronchial, Hyperplasia 1 (100%) 1 (100%)
Mediastinal, Hemorrhage 2 (100%)
Lymph Node, Mesenteric (5) (5) (5) (5) (5) (5)
Atrophy 4 (80%)
Spleen (5) (5) (5) (5) (5) (5)
Hematopoietic Cell Proliferation 4 (80%) 5 (100%) 5 (100%) 5 (100%) 5 (100%)
Thymus (5) (5) (5) (5) (5) (5)
Atrophy 4 (80%) 5 (100%) 5 (100%) 5 (100%) 5 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (5) (5) (5) (5) (5) (5)
Epidermis, Skin, Site of Application,
Degeneration 2 (40%) 3 (60%) 5 (100%) 5 (100%) 5 (100%)
Hair Follicle, Skin, Site of Application,
Hyperplasia 5 (100%) 5 (100%) 5 (100%) 5 (100%) 5 (100%)
Skin, Site of Application, Hyperplasia 5 (100%) 5 (100%) 5 (100%) 5 (100%) 5 (100%)
Skin, Site of Application, Inflammation 5 (100%) 5 (100%) 5 (100%) 5 (100%) 5 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (5) (1) (5)
Hemorrhage, Acute, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:17:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 12.5 25 MG/KG 50 MG/KG 100 200
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5) (5) (5) (5) (5)
Infiltration Cellular, Histiocyte 1 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:17:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 12.5 25 MG/KG 50 MG/KG 100 200
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 5 5 5 5 5 5
Early Deaths
Survivors
Terminal Sacrifice 5 5 5 5 5 4
Accidently Killed 1
Animals Examined Microscopically 5 5 5 5 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (5) (5) (5) (5) (5) (5)
Hematopoietic Cell Proliferation 3 (60%)
Hepatodiaphragmatic Nodule 1 (20%) 1 (20%)
Inflammation, Focal 1 (20%) 1 (20%)
Pancreas (5) (5)
Infiltration Cellular, Focal, Lymphocyte 3 (60%) 2 (40%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (5) (1) (5)
Hemorrhage, Acute, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:17:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 12.5 25 MG/KG 50 MG/KG 100 200
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Bone Marrow (5) (5)
Myeloid Cell, Hyperplasia 1 (20%)
Lymph Node (1) (1)
Bronchial, Hemorrhage 1 (100%)
Bronchial, Hyperplasia 1 (100%) 1 (100%)
Lymph Node, Mesenteric (5) (4) (5) (5) (5) (5)
Atrophy 2 (50%) 2 (40%) 2 (40%) 3 (60%) 5 (100%)
Spleen (5) (5) (5) (5) (5) (5)
Accessory Spleen 1 (20%)
Hematopoietic Cell Proliferation 5 (100%) 5 (100%) 5 (100%) 5 (100%) 5 (100%) 5 (100%)
Pigmentation 1 (20%)
Thymus (5) (5) (5) (5) (5) (5)
Atrophy 5 (100%) 5 (100%) 5 (100%) 5 (100%) 5 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (5) (5) (5) (5) (5) (5)
Epidermis, Skin, Site of Application,
Degeneration 5 (100%) 5 (100%) 5 (100%) 5 (100%)
Hair Follicle, Skin, Site of Application,
Hyperplasia 4 (80%) 5 (100%) 5 (100%) 5 (100%) 5 (100%)
Skin, Site of Application, Hyperplasia 5 (100%) 5 (100%) 5 (100%) 5 (100%) 5 (100%)
Skin, Site of Application, Inflammation 5 (100%) 5 (100%) 3 (60%) 5 (100%) 5 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:17:07
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 12.5 25 MG/KG 50 MG/KG 100 200
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5) (5) (5) (5) (5)
Infiltration Cellular, Histiocyte 1 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
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