National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4847

TDMS Study 96002-01 Pathology Tables

NTP Experiment-Test: 96002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00
Route: SKIN APPLICATION                                                                                           Time: 08:17:07

                                                 FINAL #1; 17 DAY REPEATED DOSE




       Facility:  BIORELIANCE

       Chemical CAS #:  136-35-6

       Lock Date:  01/21/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 96002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:07    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      12.5         25 MG/KG     50 MG/KG     100          200             
                                                                MG/KG                                  MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                           5            5            5            5            5            5           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                 5            5            5            5            5            5           
                                                                                                                                    
  Animals Examined Microscopically                     5            5            5            5            5            5           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (5)          (5)          (5)          (5)          (5)          (5)          
      Hematopoietic Cell Proliferation                                                                     1 (20%)      2 (40%)     
      Hepatodiaphragmatic Nodule                       1 (20%)      1 (20%)                   1 (20%)                   1 (20%)     
      Inflammation, Focal                              1 (20%)      3 (60%)      1 (20%)                                            
   Pancreas                                           (5)                                                              (5)          
      Infiltration Cellular, Focal, Lymphocyte         3 (60%)                                                          4 (80%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                      (2)                       (1)                       (1)          
      Bronchial, Hemorrhage                                                                                             1 (100%)    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:07    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      12.5         25 MG/KG     50 MG/KG     100          200             
                                                                MG/KG                                  MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Bronchial, Hyperplasia                                                                  1 (100%)                  1 (100%)    
      Mediastinal, Hemorrhage                                       2 (100%)                                                        
   Lymph Node, Mesenteric                             (5)          (5)          (5)          (5)          (5)          (5)          
      Atrophy                                                                                                           4 (80%)     
   Spleen                                             (5)          (5)          (5)          (5)          (5)          (5)          
      Hematopoietic Cell Proliferation                              4 (80%)      5 (100%)     5 (100%)     5 (100%)     5 (100%)    
   Thymus                                             (5)          (5)          (5)          (5)          (5)          (5)          
      Atrophy                                                       4 (80%)      5 (100%)     5 (100%)     5 (100%)     5 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (5)          (5)          (5)          (5)          (5)          (5)          
      Epidermis, Skin, Site of Application,                                                                                         
          Degeneration                                              2 (40%)      3 (60%)      5 (100%)     5 (100%)     5 (100%)    
      Hair Follicle, Skin, Site of Application,                                                                                     
           Hyperplasia                                              5 (100%)     5 (100%)     5 (100%)     5 (100%)     5 (100%)    
      Skin, Site of Application, Hyperplasia                        5 (100%)     5 (100%)     5 (100%)     5 (100%)     5 (100%)    
      Skin, Site of Application, Inflammation                       5 (100%)     5 (100%)     5 (100%)     5 (100%)     5 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (5)          (1)                                                 (5)          
      Hemorrhage, Acute, Focal                                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:07    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      12.5         25 MG/KG     50 MG/KG     100          200             
                                                                MG/KG                                  MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (5)          (5)          (5)          (5)          (5)          (5)          
      Infiltration Cellular, Histiocyte                                                                                 1 (20%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                      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NTP Experiment-Test: 96002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:07    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      12.5         25 MG/KG     50 MG/KG     100          200             
                                                                MG/KG                                  MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                           5            5            5            5            5            5           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                 5            5            5            5            5            4           
    Accidently Killed                                                                                                   1           
                                                                                                                                    
  Animals Examined Microscopically                     5            5            5            5            5            5           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (5)          (5)          (5)          (5)          (5)          (5)          
      Hematopoietic Cell Proliferation                                                                                  3 (60%)     
      Hepatodiaphragmatic Nodule                                                              1 (20%)      1 (20%)                  
      Inflammation, Focal                                                                     1 (20%)                   1 (20%)     
   Pancreas                                           (5)                                                              (5)          
      Infiltration Cellular, Focal, Lymphocyte         3 (60%)                                                          2 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (5)          (1)                                                 (5)          
      Hemorrhage, Acute, Focal                                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:07    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      12.5         25 MG/KG     50 MG/KG     100          200             
                                                                MG/KG                                  MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Bone Marrow                                        (5)                                                              (5)          
      Myeloid Cell, Hyperplasia                                                                                         1 (20%)     
   Lymph Node                                                                                (1)                       (1)          
      Bronchial, Hemorrhage                                                                   1 (100%)                              
      Bronchial, Hyperplasia                                                                  1 (100%)                  1 (100%)    
   Lymph Node, Mesenteric                             (5)          (4)          (5)          (5)          (5)          (5)          
      Atrophy                                                       2 (50%)      2 (40%)      2 (40%)      3 (60%)      5 (100%)    
   Spleen                                             (5)          (5)          (5)          (5)          (5)          (5)          
      Accessory Spleen                                                                                                  1 (20%)     
      Hematopoietic Cell Proliferation                 5 (100%)     5 (100%)     5 (100%)     5 (100%)     5 (100%)     5 (100%)    
      Pigmentation                                                                                                      1 (20%)     
   Thymus                                             (5)          (5)          (5)          (5)          (5)          (5)          
      Atrophy                                                       5 (100%)     5 (100%)     5 (100%)     5 (100%)     5 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (5)          (5)          (5)          (5)          (5)          (5)          
      Epidermis, Skin, Site of Application,                                                                                         
          Degeneration                                                           5 (100%)     5 (100%)     5 (100%)     5 (100%)    
      Hair Follicle, Skin, Site of Application,                                                                                     
           Hyperplasia                                              4 (80%)      5 (100%)     5 (100%)     5 (100%)     5 (100%)    
      Skin, Site of Application, Hyperplasia                        5 (100%)     5 (100%)     5 (100%)     5 (100%)     5 (100%)    
      Skin, Site of Application, Inflammation                       5 (100%)     5 (100%)     3 (60%)      5 (100%)     5 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:07    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      12.5         25 MG/KG     50 MG/KG     100          200             
                                                                MG/KG                                  MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (5)          (5)          (5)          (5)          (5)          (5)          
      Infiltration Cellular, Histiocyte                                                                    1 (20%)                  
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                      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