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TDMS Study 96002-01 Pathology Tables

NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00
Route: SKIN APPLICATION                                                                                           Time: 08:17:17

                                                 FINAL #1; 17 DAY REPEATED DOSE




       Facility:  BIORELIANCE

       Chemical CAS #:  136-35-6

       Lock Date:  01/21/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Hepatodiaphragmatic Nodule           |          X                                                               |      1     |
      Inflammation, Focal                  |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |       1  2  2                                                            |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +                                                            |   4        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  M  +  +  +                                                            |   4        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  M  +  +  +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M                                                            |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 MG/KG                                | 3| 3| 3| 3| 3|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  M  +  +  +                                                            |   4        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    12.5                                   | 3| 3| 3| 3| 4|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Hepatodiaphragmatic Nodule           |    X                                                                     |      1     |
      Inflammation, Focal                  |    1     1  1                                                            |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +        +                                                               |   2        |
      Mediastinal, Hemorrhage              | 2        2                                                               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     |    1  1  1  1                                                            |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 1  1  1     1                                                            |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    12.5                                   | 3| 3| 3| 3| 4|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Degeneration                    |    2  2                                                                  |      2  2.0|
      Hair Follicle, Skin, Site of         |                                                                          |            |
          Application, Hyperplasia         | 2  3  3  2  1                                                            |      5  2.2|
      Skin, Site of Application,           |                                                                          |            |
          Hyperplasia                      | 2  2  2  1  2                                                            |      5  1.8|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation                     | 2  2  1  2  2                                                            |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +                                                                        |   1        |
      Hemorrhage, Acute, Focal             | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    25 MG/KG                               | 4| 4| 4| 4| 4|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Inflammation, Focal                  |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     | 1  1  1  1  1                                                            |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 1  1  2  1  1                                                            |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Degeneration                    | 1  3     3                                                               |      3  2.3|
      Hair Follicle, Skin, Site of         |                                                                          |            |
          Application, Hyperplasia         | 3  3  3  3  3                                                            |      5  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    25 MG/KG                               | 4| 4| 4| 4| 4|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Skin, Site of Application,           |                                                                          |            |
          Hyperplasia                      | 2  2  2  2  2                                                            |      5  2.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation                     | 1  1  1  1  1                                                            |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    50 MG/KG                               | 4| 4| 4| 4| 5|                                                           |      L     |
                                           | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Hepatodiaphragmatic Nodule           | X                                                                        |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   1        |
      Bronchial, Hyperplasia               |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     | 1  2  1  1  1                                                            |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 2  3  3  3  2                                                            |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    50 MG/KG                               | 4| 4| 4| 4| 5|                                                           |      L     |
                                           | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
           Degeneration                    | 3  3  4  3  3                                                            |      5  3.2|
      Hair Follicle, Skin, Site of         |                                                                          |            |
          Application, Hyperplasia         | 3  3  3  3  3                                                            |      5  3.0|
      Skin, Site of Application,           |                                                                          |            |
          Hyperplasia                      | 2  2  3  2  2                                                            |      5  2.2|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation                     | 1  1  1  1  1                                                            |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    100                                    | 5| 5| 5| 5| 5|                                                           |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     | 2  2  2  2  2                                                            |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 3  2  3  3  3                                                            |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Degeneration                    | 3  3  3  3  3                                                            |      5  3.0|
      Hair Follicle, Skin, Site of         |                                                                          |            |
          Application, Hyperplasia         | 3  3  3  3  1                                                            |      5  2.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    100                                    | 5| 5| 5| 5| 5|                                                           |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Skin, Site of Application,           |                                                                          |            |
          Hyperplasia                      | 2  2  2  2  2                                                            |      5  2.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation                     | 1  1  1  1  1                                                            |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    200                                    | 5| 5| 5| 5| 6|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     |          1  1                                                            |      2  1.0|
      Hepatodiaphragmatic Nodule           |    X                                                                     |      1     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       | 1     2  2  2                                                            |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    200                                    | 5| 5| 5| 5| 6|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M                                                            |   3        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +                                                            |   4        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |             +                                                            |   1        |
      Bronchial, Hemorrhage                |             1                                                            |      1  1.0|
      Bronchial, Hyperplasia               |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M                                                            |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    200                                    | 5| 5| 5| 5| 6|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 1  1  1     1                                                            |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     | 2  1  2  2  2                                                            |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 3  3  3  3  3                                                            |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Degeneration                    | 2  3  2  2  3                                                            |      5  2.4|
      Hair Follicle, Skin, Site of         |                                                                          |            |
          Application, Hyperplasia         | 3  3  3  3  3                                                            |      5  3.0|
      Skin, Site of Application,           |                                                                          |            |
          Hyperplasia                      | 2  2  2  2  2                                                            |      5  2.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation                     | 1  1  1  1  1                                                            |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    200                                    | 5| 5| 5| 5| 6|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Infiltration Cellular, Histiocyte    |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       | 2  1     2                                                               |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +                                                            |   3        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M                                                            |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     | 2  1  1  1  1                                                            |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  M                                                            |   3        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    12.5                                   | 0| 0| 0| 0| 1|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Testes                                  |       +                                                                  |   1        |
      Hemorrhage, Acute, Focal             |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +                                                            |   4        |
      Atrophy                              |       1     2                                                            |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     | 1  1  1  1  1                                                            |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 1  1  1  1  1                                                            |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Hair Follicle, Skin, Site of         |                                                                          |            |
          Application, Hyperplasia         | 1  1  1     2                                                            |      4  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    12.5                                   | 0| 0| 0| 0| 1|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Skin, Site of Application,           |                                                                          |            |
          Hyperplasia                      | 2  2  2  1  1                                                            |      5  1.6|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation                     | 2  1  1  2  2                                                            |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    25 MG/KG                               | 1| 1| 1| 1| 1|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 2        2                                                               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     | 1  1  1  2  1                                                            |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 2  3  3  3  2                                                            |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Degeneration                    | 3  2  3  3  3                                                            |      5  2.8|
      Hair Follicle, Skin, Site of         |                                                                          |            |
          Application, Hyperplasia         | 2  3  3  3  3                                                            |      5  2.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    25 MG/KG                               | 1| 1| 1| 1| 1|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Skin, Site of Application,           |                                                                          |            |
          Hyperplasia                      | 2  2  2  2  2                                                            |      5  2.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation                     | 2  1  2  2  2                                                            |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    50 MG/KG                               | 1| 1| 1| 1| 2|                                                           |      L     |
                                           | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Hepatodiaphragmatic Nodule           | X                                                                        |      1     |
      Inflammation, Focal                  | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |
      Bronchial, Hemorrhage                | 1                                                                        |      1  1.0|
      Bronchial, Hyperplasia               | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              |       2  2                                                               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     | 1  2  1  2  2                                                            |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 2  3  2  3  2                                                            |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    50 MG/KG                               | 1| 1| 1| 1| 2|                                                           |      L     |
                                           | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Degeneration                    | 3  3  3  3  3                                                            |      5  3.0|
      Hair Follicle, Skin, Site of         |                                                                          |            |
          Application, Hyperplasia         | 4  4  3  3  2                                                            |      5  3.2|
      Skin, Site of Application,           |                                                                          |            |
          Hyperplasia                      | 2  2  2  2  2                                                            |      5  2.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation                     |       2  1  1                                                            |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    100                                    | 2| 2| 2| 2| 2|                                                           |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Hepatodiaphragmatic Nodule           |       X                                                                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +     +  +  +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              |    1  1  1                                                               |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     | 2  2  2  2  2                                                            |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 3  3  3  3  3                                                            |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Degeneration                    | 2  2  2  3  2                                                            |      5  2.2|
      Hair Follicle, Skin, Site of         |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    100                                    | 2| 2| 2| 2| 2|                                                           |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
          Application, Hyperplasia         | 3  3  4  4  4                                                            |      5  3.6|
      Skin, Site of Application,           |                                                                          |            |
          Hyperplasia                      | 2  2  2  2  2                                                            |      5  2.0|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation                     | 2  1  1  1  2                                                            |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Infiltration Cellular, Histiocyte    | 1                                                                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    200                                    | 2| 2| 2| 2| 3|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Hematopoietic Cell Proliferation     | 1  1  1                                                                  |      3  1.0|
      Inflammation, Focal                  |       1                                                                  |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |    2  1                                                                  |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    200                                    | 2| 2| 2| 2| 3|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +                                                            |   3        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
      Myeloid Cell, Hyperplasia            |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    200                                    | 2| 2| 2| 2| 3|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Bronchial, Hyperplasia               |    1                                                                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M                                                            |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 2  2  2  3  2                                                            |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Accessory Spleen                     |    X                                                                     |      1     |
      Hematopoietic Cell Proliferation     | 2  2  2  2  2                                                            |      5  2.0|
      Pigmentation                         |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 3  3  3  3  3                                                            |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +                                                            |   4        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Degeneration                    | 3  2  3  3  3                                                            |      5  2.8|
      Hair Follicle, Skin, Site of         |                                                                          |            |
          Application, Hyperplasia         | 4  4  4  4  4                                                            |      5  4.0|
      Skin, Site of Application,           |                                                                          |            |
          Hyperplasia                      | 3  2  2  2  2                                                            |      5  2.2|
      Skin, Site of Application,           |                                                                          |            |
          Inflammation                     | 1  1  1  1  1                                                            |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96002-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 14DAY REPEATED                               DIAZOAMINOBENZENE (DAAB)                                 Date: 09/27/00    
Route: SKIN APPLICATION                                                                                           Time: 08:17:17    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    200                                    | 2| 2| 2| 2| 3|                                                           |      L     |
    MG/KG                                  | 6| 7| 8| 9| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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