TDMS Study 96002-02 Pathology Tables
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
FINAL#1; 17 DAY REPEATED DOSE
Facility: BIORELIANCE
Chemical CAS #: 136-35-6
Lock Date: 01/21/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 MG/KG | 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
|__________________________________________________________________________|____________|
Gallbladder | + M + + + | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Inflammation, Focal | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + M | 4 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
|__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 MG/KG | 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + | 3 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
|__________________________________________________________________________|____________|
Uterus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M | 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 MG/KG | 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
|__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
12.5 | 3| 3| 3| 3| 4| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Inflammation, Focal | 1 1 1 2 1 | 5 1.2|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Epidermis, Skin, Site of Application,| | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
12.5 | 3| 3| 3| 3| 4| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperplasia | 1 1 2 1 1 | 5 1.2|
Hair Follicle, Skin, Site of | | |
Application, Hyperplasia | 2 1 2 1 2 | 5 1.6|
Skin, Site of Application, | | |
Inflammation | 2 2 2 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
25 MG/KG | 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Inflammation, Focal | 2 1 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Epidermis, Skin, Site of Application,| | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
25 MG/KG | 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperplasia | 3 3 3 3 3 | 5 3.0|
Hair Follicle, Skin, Site of | | |
Application, Hyperplasia | 3 3 4 3 3 | 5 3.2|
Skin, Site of Application, | | |
Inflammation | 1 1 1 2 1 | 5 1.2|
Skin, Site of Application, Ulcer | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
50 MG/KG | 4| 4| 4| 4| 5| | L |
| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Inflammation, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hematopoietic Cell Proliferation | 2 2 1 1 1 | 5 1.4|
|__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
Atrophy | 4 3 3 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
50 MG/KG | 4| 4| 4| 4| 5| | L |
| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 3 3 2 3 | 5 2.6|
Hair Follicle, Skin, Site of | | |
Application, Hyperplasia | 1 4 4 2 4 | 5 3.0|
Skin, Site of Application, | | |
Inflammation | 3 2 3 2 2 | 5 2.4|
Skin, Site of Application, Ulcer | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
100 | 5| 5| 5| 5| 5| | L |
MG/KG | 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
|__________________________________________________________________________|____________|
Gallbladder | M M M M M | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Inflammation, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + M + + | 4 |
|__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Atrium, Thrombosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
100 | 5| 5| 5| 5| 5| | L |
MG/KG | 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + | 4 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + M M + M | 2 |
|__________________________________________________________________________|____________|
Ovary | + + + + M | 4 |
|__________________________________________________________________________|____________|
Uterus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + | 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + M + | 3 |
Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
100 | 5| 5| 5| 5| 5| | L |
MG/KG | 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hematopoietic Cell Proliferation | 2 3 | 2 2.5|
Lymphoid Follicle, Atrophy | 3 3 2 | 3 2.7|
|__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
Atrophy | 4 4 4 2 4 | 5 3.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 3 2 2 3 2 | 5 2.4|
Hair Follicle, Skin, Site of | | |
Application, Hyperplasia | 4 3 2 4 2 | 5 3.0|
Skin, Site of Application, | | |
Inflammation | 3 2 1 3 2 | 5 2.2|
Skin, Site of Application, Ulcer | 1 1 1 2 | 4 1.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
|__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
100 | 5| 5| 5| 5| 5| | L |
MG/KG | 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Bilateral, Cortex, Renal Tubule, | | |
Necrosis | 2 3 3 2 | 4 2.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 0| 1| 1| | |
| 0| 7| 8| 7| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
200 | 5| 5| 5| 5| 6| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + M + | 4 |
|__________________________________________________________________________|____________|
Gallbladder | + + M + + | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + | 4 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + | 4 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + | 4 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Inflammation, Focal | 1 | 1 1.0|
Necrosis, Focal | 2 2 | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 0| 1| 1| | |
| 0| 7| 8| 7| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
200 | 5| 5| 5| 5| 6| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Heart | + + + + + | 5 |
Atrium, Thrombosis | 2 3 | 2 2.5|
Myocardium, Ventricle, Mineralization| 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + | 3 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + M + | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | M + M M M | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
|__________________________________________________________________________|____________|
Uterus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 0| 1| 1| | |
| 0| 7| 8| 7| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
200 | 5| 5| 5| 5| 6| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mandibular | + + + M + | 4 |
Atrophy | 3 2 1 | 3 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + | 4 |
Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Lymphoid Follicle, Atrophy | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + M + | 4 |
Atrophy | 4 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + + + + | 4 |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 3 1 2 2 | 5 2.0|
Hair Follicle, Skin, Site of | | |
Application, Hyperplasia | 3 4 4 2 2 | 5 3.0|
Skin, Site of Application, | | |
Inflammation | 2 2 2 2 3 | 5 2.2|
Skin, Site of Application, Ulcer | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 0| 1| 1| | |
| 0| 7| 8| 7| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
200 | 5| 5| 5| 5| 6| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Artery, Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
|__________________________________________________________________________|____________|
Trachea | + + + M + | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Bilateral, Cortex, Renal Tubule, | | |
Dilatation | 2 1 1 2 | 4 1.5|
Bilateral, Cortex, Renal Tubule, | | |
Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 MG/KG | 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
|__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 MG/KG | 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M | 3 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
|__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 MG/KG | 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mesenteric | + + M + + | 4 |
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
|__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Epidermis, Skin, Site of Application,| | |
Inflammation, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
|__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 MG/KG | 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
12.5 | 0| 0| 0| 0| 1| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Inflammation, Focal | 1 1 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
12.5 | 0| 0| 0| 0| 1| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 2 2 2 2 | 5 2.0|
Hair Follicle, Skin, Site of | | |
Application, Hyperplasia | 1 1 1 1 2 | 5 1.2|
Skin, Site of Application, | | |
Inflammation | 2 1 2 2 1 | 5 1.6|
Skin, Site of Application, Ulcer | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
25 MG/KG | 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Inflammation, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + M | 4 |
|__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
25 MG/KG | 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Pituitary Gland | + M M M + | 2 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
|__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
25 MG/KG | 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mesenteric | + + + M + | 4 |
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 2 3 2 1 | 5 2.0|
Hair Follicle, Skin, Site of | | |
Application, Hyperplasia | 2 2 2 1 1 | 5 1.6|
Skin, Site of Application, | | |
Inflammation | 2 2 2 2 1 | 5 1.8|
Skin, Site of Application, Ulcer | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
|__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
25 MG/KG | 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 1| 7| 4| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
50 MG/KG | 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
|__________________________________________________________________________|____________|
Gallbladder | M + M + + | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Inflammation, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + M + + | 4 |
|__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Atrium, Thrombosis | 1 3 | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 1| 7| 4| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
50 MG/KG | 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
|__________________________________________________________________________|____________|
Penis | + + | 2 |
Congestion | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | M + + + + | 4 |
|__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
|__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 1| 7| 4| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
50 MG/KG | 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
Atrophy | 2 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
Atrophy | 1 3 | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
Atrophy | 4 4 4 4 3 | 5 3.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 2 2 2 1 | 5 1.8|
Hair Follicle, Skin, Site of | | |
Application, Hyperplasia | 1 1 1 1 1 | 5 1.0|
Skin, Site of Application, | | |
Inflammation | 1 2 1 1 1 | 5 1.2|
Skin, Site of Application, Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 1| 1| 1| 1| 1| | |
| 1| 7| 4| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
50 MG/KG | 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
|__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 1| 0| | |
| 9| 8| 8| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
100 | 2| 2| 2| 2| 2| | L |
MG/KG | 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
|__________________________________________________________________________|____________|
Gallbladder | M + M + + | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Necrosis, Focal | 1 2 1 | 3 1.3|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + M + | 4 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + M + | 4 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
Ulcer, Focal | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 1| 0| | |
| 9| 8| 8| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
100 | 2| 2| 2| 2| 2| | L |
MG/KG | 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Heart | + + + + + | 5 |
Atrium, Thrombosis | 3 4 3 3 3 | 5 3.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + | 4 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M | 3 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
|__________________________________________________________________________|____________|
Penis | + | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + M | 4 |
|__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
|__________________________________________________________________________|____________|
Testes | + + + + + | 5 |
Germinal Epithelium, Degeneration | 1 3 | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 1| 0| | |
| 9| 8| 8| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
100 | 2| 2| 2| 2| 2| | L |
MG/KG | 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + | 4 |
Atrophy | 3 3 2 3 | 4 2.8|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
Atrophy | 2 2 3 | 3 2.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Lymphoid Follicle, Atrophy | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
Atrophy | 4 4 4 4 4 | 5 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 2 1 2 1 | 5 1.4|
Hair Follicle, Skin, Site of | | |
Application, Hyperplasia | 1 1 1 1 1 | 5 1.0|
Skin, Site of Application, | | |
Inflammation | 2 1 1 1 2 | 5 1.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 1| 0| | |
| 9| 8| 8| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
100 | 2| 2| 2| 2| 2| | L |
MG/KG | 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
|__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Bilateral, Cortex, Renal Tubule, | | |
Necrosis | 2 2 2 1 3 | 5 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| | |
| 9| 9| 9| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
200 | 2| 2| 2| 2| 3| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
|__________________________________________________________________________|____________|
Gallbladder | + M + + + | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
|__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Inflammation, Focal | 2 | 1 2.0|
Necrosis, Focal | 3 3 2 2 3 | 5 2.6|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
Ulcer, Focal | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| | |
| 9| 9| 9| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
200 | 2| 2| 2| 2| 3| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
Atrium, Thrombosis | 3 3 3 3 3 | 5 3.0|
Myocardium, Atrium, Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + | 5 |
|__________________________________________________________________________|____________|
Penis | + | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + M | 4 |
|__________________________________________________________________________|____________|
Prostate | + + + + + | 5 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 5 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| | |
| 9| 9| 9| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
200 | 2| 2| 2| 2| 3| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Testes | + + + + + | 5 |
Germinal Epithelium, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 5 |
Atrophy | 3 3 3 2 3 | 5 2.8|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + | 4 |
Atrophy | 3 3 2 2 | 4 2.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Lymphoid Follicle, Atrophy | 3 3 3 1 2 | 5 2.4|
|__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
Atrophy | 4 4 4 4 4 | 5 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 1 1 1 1 | 5 1.0|
Hair Follicle, Skin, Site of | | |
Application, Hyperplasia | 2 2 | 2 2.0|
Skin, Site of Application, | | |
Inflammation | 2 2 1 1 1 | 5 1.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 96002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 14DAY REPEATED DIAZOAMINOBENZENE (DAAB) Date: 09/27/00
Route: SKIN APPLICATION Time: 08:20:33
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| | |
| 9| 9| 9| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
200 | 2| 2| 2| 2| 3| | L |
MG/KG | 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Artery, Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Bilateral, Cortex, Renal Tubule, | | |
Necrosis | 3 3 3 3 3 | 5 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + M + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
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---------- END OF REPORT ----------
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