Share This:
https://ntp.niehs.nih.gov/go/4887

TDMS Study 96007-01 Pathology Tables

NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:35:00

                                                          31 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57465-28-8

       Lock Date:  01/09/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     09/24/98 - 09/25/98

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    10 NG/KG
                               Include 003    30 NG/KG
                               Include 004    100     NG/KG
                               Include 005    175     NG/KG
                               Include 006    300     NG/KG
                               Include 007    550     NG/KG
                               Include 008    1000    NG/KG


























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:35:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      10 NG/KG     30 NG/KG     100          175          300          
                                                                                             NG/KG        NG/KG        NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           48           98           98           98           98           
                                                                                                                                    
  Scheduled Sacrifice                                 16           16           15           16           16           16           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10            9           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (9)          (10)         (10)         (10)         
      Basophilic Focus                                                                        1                                     
      Cholangiofibrosis                                                                                                 1 [2.0]     
      Clear Cell Focus                                              1                                                   1           
      Degeneration, Cystic                                          1 [1.0]                                                         
      Inflammation                                     7 [1.1]     10 [1.2]      9 [1.3]     10 [1.3]     10 [1.6]     10 [1.7]     
      Mixed Cell Focus                                              2            2            3            1            1           
      Mixed Cell Focus, Multiple                                                                           2            1           
      Necrosis                                                                                1 [1.0]                               
      Pigmentation                                                                            3 [1.0]      5 [1.0]      8 [1.0]     
      Hepatocyte, Hypertrophy                                       3 [1.0]      4 [1.3]      6 [1.0]      6 [1.3]      8 [1.0]     
   Pancreas                                           (10)         (10)         (9)          (10)         (10)         (10)         
      Basophilic Focus                                                                                                  1           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (9)          (10)         (10)         (10)         
      Angiectasis                                                   1 [2.0]                                                         
      Degeneration, Cystic                                                                                 1 [1.0]                  
      Hyperplasia                                                                1 [1.0]      1 [1.0]                               
      Hypertrophy                                      2 [1.0]      3 [1.0]      2 [1.0]      3 [1.3]      2 [1.5]      4 [1.5]     
   Adrenal Medulla                                    (10)                                                                          
      Hyperplasia                                      1 [1.0]                                                                      
   Thyroid Gland                                      (10)         (3)          (3)          (5)          (6)          (5)          
      Follicular Cell, Hypertrophy                                  3 [1.0]      3 [1.3]      5 [1.8]      6 [2.3]      5 [1.2]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:35:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      10 NG/KG     30 NG/KG     100          175          300          
                                                                                             NG/KG        NG/KG        NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (9)          (10)         (10)         (10)         
      Atrophy                                          8 [3.9]      8 [4.0]      4 [4.0]     10 [4.0]      9 [4.0]     10 [4.0]     
   Uterus                                             (10)                                   (1)          (1)                       
      Inflammation, Suppurative                        1 [1.0]                                             1 [1.0]                  
      Metaplasia, Squamous                             5 [1.6]                                             1 [1.0]                  
      Endometrium, Hyperplasia, Cystic                 1 [1.0]                                1 [4.0]      1 [4.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                                          
      Pigmentation                                    10 [1.7]                                                                      
   Thymus                                             (10)         (10)         (9)          (10)         (10)         (10)         
      Atrophy                                          2 [1.0]      3 [1.0]      1 [1.0]      3 [1.0]      3 [1.0]      3 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (9)          (10)         (10)         (10)         
      Infiltration Cellular, Histiocyte                2 [1.0]      3 [1.0]      2 [1.0]      3 [1.0]      1 [1.0]      1 [1.0]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:35:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      10 NG/KG     30 NG/KG     100          175          300          
                                                                                             NG/KG        NG/KG        NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Metaplasia, Bronchiolar                                                                      1 [1.0]     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:35:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   550          1000                                                             
                                                      NG/KG        NG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98                                                               
                                                                                                                                    
  Scheduled Sacrifice                                 16           16                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)                                                             
      Cholangiofibrosis                                1 [1.0]                                                                      
      Fatty Change, Diffuse                                         1 [1.0]                                                         
      Hepatocyte, Multinucleate                        2 [1.0]      8 [1.0]                                                         
      Inflammation                                    10 [1.8]     10 [1.8]                                                         
      Mixed Cell Focus                                 2            2                                                               
      Mixed Cell Focus, Multiple                       1            4                                                               
      Necrosis                                         1 [1.0]      2 [1.5]                                                         
      Pigmentation                                     8 [1.0]     10 [1.0]                                                         
      Toxic Hepatopathy                                            10 [1.2]                                                         
      Hepatocyte, Hypertrophy                         10 [1.4]     10 [2.2]                                                         
   Pancreas                                           (10)         (10)                                                             
      Inflammation, Chronic Active                                  1 [1.0]                                                         
      Acinus, Atrophy                                               1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)                                                             
      Hyperplasia                                                   1 [2.0]                                                         
      Hypertrophy                                                   4 [1.3]                                                         
   Thyroid Gland                                      (5)          (10)                                                             
      Follicular Cell, Hypertrophy                     5 [1.2]      7 [1.9]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:35:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   550          1000                                                             
                                                      NG/KG        NG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)                                                             
      Atrophy                                          7 [4.0]      4 [3.5]                                                         
   Uterus                                                          (10)                                                             
      Inflammation, Suppurative                                     1 [1.0]                                                         
      Metaplasia, Squamous                                          4 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (1)          (10)                                                             
      Hematopoietic Cell Proliferation                 1 [3.0]                                                                      
      Pigmentation                                                 10 [1.6]                                                         
   Thymus                                             (10)         (10)                                                             
      Atrophy                                          8 [1.3]     10 [2.2]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)                                                             
      Infiltration Cellular, Histiocyte                1 [1.0]      4 [1.0]                                                         
      Alveolar Epithelium, Metaplasia, Bronchiolar                  2 [1.0]                                                         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:35:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   550          1000                                                             
                                                      NG/KG        NG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------