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TDMS Study 96007-01 Pathology Tables

NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02
Route: GAVAGE                                                                                                     Time: 15:35:06

                                                          53 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57465-28-8

       Lock Date:  01/09/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     02/25/99 - 02/26/99

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    10 NG/KG
                               Include 003    30 NG/KG
                               Include 004    100     NG/KG
                               Include 005    175     NG/KG
                               Include 006    300     NG/KG
                               Include 007    550     NG/KG
                               Include 008    1000    NG/KG



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:35:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      10 NG/KG     30 NG/KG     100          175          300             
                                                                                          NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           48           98           98           98           98           
                                                                                                                                    
  Scheduled Sacrifice                                 13           15           13           13           13           13           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8            8            8            8            8            8           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (8)          (8)          (8)          (8)          (8)          
      Basophilic Focus                                 2 (25%)      2 (25%)                   1 (13%)      2 (25%)                  
      Cholangiofibrosis                                                                       1 (13%)                               
      Clear Cell Focus                                                                                                  1 (13%)     
      Clear Cell Focus, Multiple                                                                                        1 (13%)     
      Eosinophilic Focus                                                                                   1 (13%)                  
      Eosinophilic Focus, Multiple                                                                         1 (13%)                  
      Fatty Change, Diffuse                                                                                2 (25%)                  
      Hepatocyte, Multinucleate                                                                                         1 (13%)     
      Inflammation                                     8 (100%)     8 (100%)     8 (100%)     8 (100%)     8 (100%)     8 (100%)    
      Mixed Cell Focus                                 3 (38%)      3 (38%)      1 (13%)                   3 (38%)      2 (25%)     
      Mixed Cell Focus, Multiple                       1 (13%)      2 (25%)      2 (25%)      6 (75%)      3 (38%)      4 (50%)     
      Necrosis                                         1 (13%)                                                                      
      Pigmentation                                                               3 (38%)      8 (100%)     7 (88%)      8 (100%)    
      Toxic Hepatopathy                                                                                    1 (13%)                  
      Bile Duct, Cyst                                                                                                   1 (13%)     
      Bile Duct, Hyperplasia                                                                                            1 (13%)     
      Hepatocyte, Hypertrophy                                       3 (38%)      2 (25%)      5 (63%)      6 (75%)      7 (88%)     
   Pancreas                                           (8)          (8)          (7)          (8)          (8)          (8)          
      Inflammation, Chronic Active                                                                                      1 (13%)     
      Acinus, Atrophy                                                                                                   1 (13%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (8)          (8)          (8)          (8)          (8)          (8)          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:35:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      10 NG/KG     30 NG/KG     100          175          300             
                                                                                          NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Degeneration, Cystic                                                                                              1 (13%)     
      Hyperplasia                                                   1 (13%)      1 (13%)      3 (38%)      1 (13%)      1 (13%)     
      Hypertrophy                                      5 (63%)      6 (75%)      3 (38%)      3 (38%)      1 (13%)      4 (50%)     
      Vacuolization Cytoplasmic                                                               1 (13%)      1 (13%)                  
   Pituitary Gland                                    (8)                                                                           
      Pars Distalis, Hyperplasia                       2 (25%)                                                                      
   Thyroid Gland                                      (8)          (3)          (1)          (3)          (3)          (3)          
      C-Cell, Hyperplasia                              2 (25%)                                                                      
      Follicular Cell, Hypertrophy                     1 (13%)      3 (100%)     1 (100%)     3 (100%)     3 (100%)     3 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)          (8)          (8)          (8)          (8)          (8)          
      Atrophy                                          8 (100%)     7 (88%)      7 (88%)      8 (100%)     6 (75%)      8 (100%)    
      Cyst                                                          1 (13%)                                                         
   Uterus                                             (8)                       (2)                                    (2)          
      Inflammation, Suppurative                        3 (38%)                   2 (100%)                               2 (100%)    
      Metaplasia, Squamous                             8 (100%)                  1 (50%)                                2 (100%)    
      Endometrium, Hyperplasia, Cystic                                           2 (100%)                               1 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (8)                                                                           
      Pigmentation                                     8 (100%)                                                                     
   Thymus                                             (8)          (8)          (8)          (8)          (7)          (8)          
      Atrophy                                          7 (88%)      5 (63%)      6 (75%)      5 (63%)      5 (71%)      7 (88%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (8)                                    (1)          (2)                       
      Galactocele                                      1 (13%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:35:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      10 NG/KG     30 NG/KG     100          175          300             
                                                                                          NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (8)          (8)          (8)          (8)          (8)          
      Infiltration Cellular, Histiocyte                3 (38%)      4 (50%)      6 (75%)      5 (63%)      4 (50%)      2 (25%)     
      Inflammation, Chronic Active                     1 (13%)                                1 (13%)                               
      Alveolar Epithelium, Metaplasia, Bronchiolar                                                         1 (13%)      1 (13%)     
      Interstitium, Inflammation                                                                           1 (13%)                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:35:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                550          1000                                                                
                                                   NG/KG        NG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98                                                               
                                                                                                                                    
  Scheduled Sacrifice                                 13           13                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8            8                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (8)                                                              
      Basophilic Focus                                 1 (13%)      2 (25%)                                                         
      Cholangiofibrosis                                1 (13%)                                                                      
      Clear Cell Focus                                 1 (13%)                                                                      
      Eosinophilic Focus, Multiple                     1 (13%)      3 (38%)                                                         
      Fatty Change, Diffuse                            1 (13%)      8 (100%)                                                        
      Fatty Change, Focal                              1 (13%)                                                                      
      Hepatocyte, Multinucleate                        3 (38%)      8 (100%)                                                        
      Inflammation                                     8 (100%)     8 (100%)                                                        
      Mixed Cell Focus                                 1 (13%)                                                                      
      Mixed Cell Focus, Multiple                       7 (88%)      8 (100%)                                                        
      Necrosis                                         1 (13%)                                                                      
      Pigmentation                                     8 (100%)     8 (100%)                                                        
      Toxic Hepatopathy                                4 (50%)      8 (100%)                                                        
      Vacuolization Cytoplasmic                                     1 (13%)                                                         
      Bile Duct, Hyperplasia                           4 (50%)      6 (75%)                                                         
      Hepatocyte, Hypertrophy                          8 (100%)     8 (100%)                                                        
   Pancreas                                           (8)          (8)                                                              
      Inflammation, Chronic Active                                  1 (13%)                                                         
      Acinus, Atrophy                                               1 (13%)                                                         
      Acinus, Vacuolization Cytoplasmic                1 (13%)      6 (75%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (8)          (8)                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:35:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                550          1000                                                                
                                                   NG/KG        NG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Atrophy                                                       1 (13%)                                                         
      Degeneration, Cystic                                          2 (25%)                                                         
      Hyperplasia                                      2 (25%)      3 (38%)                                                         
      Hypertrophy                                      5 (63%)      5 (63%)                                                         
   Thyroid Gland                                      (2)          (8)                                                              
      Follicular Cell, Hypertrophy                     2 (100%)     5 (63%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)          (8)                                                              
      Atrophy                                          7 (88%)      7 (88%)                                                         
      Cyst                                             1 (13%)      1 (13%)                                                         
   Uterus                                                          (8)                                                              
      Inflammation, Suppurative                                     1 (13%)                                                         
      Metaplasia, Squamous                                          7 (88%)                                                         
      Cervix, Cyst                                                  1 (13%)                                                         
      Endometrium, Hyperplasia, Cystic                              1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (1)          (8)                                                              
      Infarct                                          1 (100%)                                                                     
      Pigmentation                                     1 (100%)     8 (100%)                                                        
   Thymus                                             (8)          (7)                                                              
      Atrophy                                          8 (100%)     7 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (1)          (8)                                                              
      Hyperplasia                                                   1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:35:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                550          1000                                                                
                                                   NG/KG        NG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (8)                                                              
      Infiltration Cellular, Histiocyte                3 (38%)      6 (75%)                                                         
      Alveolar Epithelium, Metaplasia, Bronchiolar     2 (25%)      6 (75%)                                                         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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