Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/4895

TDMS Study 96007-01 Pathology Tables

NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02
Route: GAVAGE                                                                                                     Time: 15:42:03

                                                          53 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57465-28-8

       Lock Date:  01/09/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     02/25/99 - 02/26/99

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    10 NG/KG
                               Include 003    30 NG/KG
                               Include 004    100     NG/KG
                               Include 005    175     NG/KG
                               Include 006    300     NG/KG
                               Include 007    550     NG/KG
                               Include 008    1000    NG/KG





























                                                              Page   1


NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG/KG                                | 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 7| 8|                                   |      L     |
                                           | 4| 1| 2| 3| 4| 5| 7| 8| 0| 4| 0| 6| 2|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +                                                |   8        |
      Basophilic Focus                     |    X        X                                                            |      2     |
      Inflammation                         |    1  2  1  1  1  1  1  1                                                |      8  1.1|
      Mixed Cell Focus                     |    X           X  X                                                      |      3     |
      Mixed Cell Focus, Multiple           |             X                                                            |      1     |
      Necrosis                             |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +                                                |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +                                                |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +  +  +  +                                                |   8        |
      Hypertrophy                          |    1     1  2        1  2                                                |      5  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +  +  +  +  +                                                |   8        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +                                                |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  +  +                                                |   8        |
      Pars Distalis, Hyperplasia           |       2           1                                                      |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +                                                |   8        |
      C-Cell, Hyperplasia                  |    1        2                                                            |      2  1.5|
      Follicular Cell, Hypertrophy         |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG/KG                                | 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 7| 8|                                   |      L     |
                                           | 4| 1| 2| 3| 4| 5| 7| 8| 0| 4| 0| 6| 2|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +  +  +  +                                                |   8        |
      Atrophy                              |    4  4  4  4  4  4  4  4                                                |      8  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +  +  +  +                                                |   8        |
      Inflammation, Suppurative            |    1  1  1                                                               |      3  1.0|
      Metaplasia, Squamous                 |    3  2  2  2  2  4  4  3                                                |      8  2.8|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |    +  +  +  +  +  +  +  +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +  +  +  +                                                |   8        |
      Pigmentation                         |    1  1  1  1  1  1  1  1                                                |      8  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +  +  +  +                                                |   8        |
      Atrophy                              |    3  2  1     2  2  2  2                                                |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +  +  +  +                                                |   8        |
      Galactocele                          |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +                                                |   8        |
      Infiltration Cellular, Histiocyte    |                1  1     1                                                |      3  1.0|
      Inflammation, Chronic Active         |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG/KG                                | 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 7| 8|                                   |      L     |
                                           | 4| 1| 2| 3| 4| 5| 7| 8| 0| 4| 0| 6| 2|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    10 NG/KG                               | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4|                             |      L     |
                                           | 2| 4| 5| 2| 3| 4| 5| 2| 2| 3| 4| 5| 2| 6| 8|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +                                                   |   8        |
      Basophilic Focus                     | X           X                                                            |      2     |
      Inflammation                         | 1  1  1  1  1  1  1  1                                                   |      8  1.0|
      Mixed Cell Focus                     |    X     X        X                                                      |      3     |
      Mixed Cell Focus, Multiple           | X           X                                                            |      2     |
      Hepatocyte, Hypertrophy              |    1  1           1                                                      |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +                                                   |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +                                                   |   8        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
      Hypertrophy                          |    1  3  2  2  1     1                                                   |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +           +                                                      |   3        |
      Follicular Cell, Hypertrophy         |    1  2           1                                                      |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +                                                   |   8        |
      Atrophy                              | 4  4  4  4  4  4     4                                                   |      7  4.0|
      Cyst                                 |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +                                                   |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                             |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|                             |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      A     |
    10 NG/KG                               | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4|                             |      L     |
                                           | 2| 4| 5| 2| 3| 4| 5| 2| 2| 3| 4| 5| 2| 6| 8|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Atrophy                              | 2  2           2  2  3                                                   |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +                                                   |   8        |
      Infiltration Cellular, Histiocyte    | 1  1  1              1                                                   |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    30 NG/KG                               | 0| 2| 4| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|                                   |      L     |
                                           | 9| 9| 6| 3| 6| 1| 2| 4| 1| 2| 3| 4| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +  +  +  +  +                                    |   8        |
      Inflammation                         |                1  1  1  1  1  2  1  1                                    |      8  1.1|
      Mixed Cell Focus                     |                         X                                                |      1     |
      Mixed Cell Focus, Multiple           |                X                 X                                       |      2     |
      Pigmentation                         |                   1  1           1                                       |      3  1.0|
      Hepatocyte, Hypertrophy              |                         1     1                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +  +  +  +                                       |   7        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |                +  +  +  +  +  +  +  +                                    |   8        |
      Hyperplasia                          |                                     1                                    |      1  1.0|
      Hypertrophy                          |                   1  1  1                                                |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |                +                                                         |   1        |
      Follicular Cell, Hypertrophy         |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |                +  +  +  +  +  +  +  +                                    |   8        |
      Atrophy                              |                4  4  4  4  4  4     4                                    |      7  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |                   +           +                                          |   2        |
      Inflammation, Suppurative            |                   2           1                                          |      2  1.5|
      Metaplasia, Squamous                 |                   2                                                      |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                   3           4                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    30 NG/KG                               | 0| 2| 4| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|                                   |      L     |
                                           | 9| 9| 6| 3| 6| 1| 2| 4| 1| 2| 3| 4| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |                +  +  +  +  +  +  +  +                                    |   8        |
      Atrophy                              |                2     2  2  2     2  2                                    |      6  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +  +  +  +  +                                    |   8        |
      Infiltration Cellular, Histiocyte    |                1  1  1     1  1     1                                    |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |      A     |
    100                                    | 0| 1| 2| 2| 2| 2| 2| 3| 5| 5| 6| 8| 9|                                   |      L     |
    NG/KG                                  | 2| 4| 0| 6| 7| 8| 9| 0| 8| 9| 0| 9| 2|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |          +  +  +  +  +  +  +  +                                          |   8        |
      Basophilic Focus                     |                X                                                         |      1     |
      Cholangiofibrosis                    |                1                                                         |      1  1.0|
      Inflammation                         |          1  1  1  1  1  1  1  1                                          |      8  1.0|
      Mixed Cell Focus, Multiple           |          X     X     X  X  X  X                                          |      6     |
      Pigmentation                         |          1  1  1  1  1  1  1  1                                          |      8  1.0|
      Hepatocyte, Hypertrophy              |          1        2  1     1  1                                          |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |          +  +  +  +  +  +  +  +                                          |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |          +  +  +  +  +  +  +  +                                          |   8        |
      Hyperplasia                          |                2  1        1                                             |      3  1.3|
      Hypertrophy                          |          1  1           1                                                |      3  1.0|
      Vacuolization Cytoplasmic            |             1                                                            |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |          +     +  +                                                      |   3        |
      Follicular Cell, Hypertrophy         |          1     1  1                                                      |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |          +  +  +  +  +  +  +  +                                          |   8        |
      Atrophy                              |          4  4  4  4  4  4  4  4                                          |      8  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |      A     |
    100                                    | 0| 1| 2| 2| 2| 2| 2| 3| 5| 5| 6| 8| 9|                                   |      L     |
    NG/KG                                  | 2| 4| 0| 6| 7| 8| 9| 0| 8| 9| 0| 9| 2|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  |          +  +  +  +  +  +  +  +                                          |   8        |
      Atrophy                              |          3        2     2  2  2                                          |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |          +  +  +  +  +  +  +  +                                          |   8        |
      Infiltration Cellular, Histiocyte    |          1     1     1  1     1                                          |      5  1.0|
      Inflammation, Chronic Active         |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    175                                    | 1| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9| 9|                                   |      L     |
    NG/KG                                  | 2| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 0| 4|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +     +  +  +  +  +                                          |   8        |
      Basophilic Focus                     |                   X  X                                                   |      2     |
      Eosinophilic Focus                   |                      X                                                   |      1     |
      Eosinophilic Focus, Multiple         |                   X                                                      |      1     |
      Fatty Change, Diffuse                |                   1  1                                                   |      2  1.0|
      Inflammation                         |       1  1  1     1  1  1  1  2                                          |      8  1.1|
      Mixed Cell Focus                     |             X           X  X                                             |      3     |
      Mixed Cell Focus, Multiple           |          X        X  X                                                   |      3     |
      Pigmentation                         |       1  2  1     1  1  1  1                                             |      7  1.1|
      Toxic Hepatopathy                    |                      1                                                   |      1  1.0|
      Hepatocyte, Hypertrophy              |       1     1     1  1     1  1                                          |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +     +  +  +  +  +                                          |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +     +  +  +  +  +                                          |   8        |
      Hyperplasia                          |          1                                                               |      1  1.0|
      Hypertrophy                          |                            1                                             |      1  1.0|
      Vacuolization Cytoplasmic            |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |                      +     +  +                                          |   3        |
      Follicular Cell, Hypertrophy         |                      1     1  1                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +  +  +     +  +  +  +  +                                          |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    175                                    | 1| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9| 9|                                   |      L     |
    NG/KG                                  | 2| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 0| 4|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Atrophy                              |       4  4  4           4  4  4                                          |      6  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  M  +     +  +  +  +  +                                          |   7        |
      Atrophy                              |             2     3     2  2  2                                          |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                   +  +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |       +  +  +     +  +  +  +  +                                          |   8        |
      Infiltration Cellular, Histiocyte    |          1  1     1     1                                                |      4  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |             1                                                            |      1  1.0|
      Interstitium, Inflammation           |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                   |      A     |
    300                                    | 2| 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7|                                   |      L     |
    NG/KG                                  | 0| 8| 4| 2| 6| 8| 0| 4| 6| 7| 8| 9| 0|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +  +  +     +  +  +  +  +                                    |   8        |
      Clear Cell Focus                     |                X                                                         |      1     |
      Clear Cell Focus, Multiple           |                            X                                             |      1     |
      Hepatocyte, Multinucleate            |             1                                                            |      1  1.0|
      Inflammation                         |             2  1  1     1  1  2  1  1                                    |      8  1.3|
      Mixed Cell Focus                     |             X                 X                                          |      2     |
      Mixed Cell Focus, Multiple           |                X        X  X        X                                    |      4     |
      Pigmentation                         |             1  1  2     1  1  2  1  1                                    |      8  1.3|
      Bile Duct, Cyst                      |                                     2                                    |      1  2.0|
      Bile Duct, Hyperplasia               |                                  1                                       |      1  1.0|
      Hepatocyte, Hypertrophy              |             1  1  1     1  1     1  1                                    |      7  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |             +  +  +     +  +  +  +  +                                    |   8        |
      Inflammation, Chronic Active         |                   1                                                      |      1  1.0|
      Acinus, Atrophy                      |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |             +  +  +     +  +  +  +  +                                    |   8        |
      Degeneration, Cystic                 |                                     2                                    |      1  2.0|
      Hyperplasia                          |                2                                                         |      1  2.0|
      Hypertrophy                          |                1  1        1        3                                    |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |                +           +     +                                       |   3        |
      Follicular Cell, Hypertrophy         |                1           1     1                                       |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                   |      A     |
    300                                    | 2| 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7|                                   |      L     |
    NG/KG                                  | 0| 8| 4| 2| 6| 8| 0| 4| 6| 7| 8| 9| 0|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |             +  +  +     +  +  +  +  +                                    |   8        |
      Atrophy                              |             4  4  4     4  4  4  4  4                                    |      8  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |             +     +                                                      |   2        |
      Inflammation, Suppurative            |             2     2                                                      |      2  2.0|
      Metaplasia, Squamous                 |             4     2                                                      |      2  3.0|
      Endometrium, Hyperplasia, Cystic     |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |             +  +  +     +  +  +  +  +                                    |   8        |
      Atrophy                              |             3  2  3     2  2  3  2                                       |      7  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |             +  +  +     +  +  +  +  +                                    |   8        |
      Infiltration Cellular, Histiocyte    |                1  1                                                      |      2  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                   |      A     |
    300                                    | 2| 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7|                                   |      L     |
    NG/KG                                  | 0| 8| 4| 2| 6| 8| 0| 4| 6| 7| 8| 9| 0|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |      A     |
    550                                    | 0| 1| 1| 2| 3| 3| 5| 9| 9| 9| 9| 9| 9|                                   |      L     |
    NG/KG                                  | 8| 7| 8| 0| 3| 6| 4| 1| 2| 3| 4| 5| 8|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +           +  +  +  +  +                                       |   8        |
      Basophilic Focus                     |                                  X                                       |      1     |
      Cholangiofibrosis                    |                               2                                          |      1  2.0|
      Clear Cell Focus                     |                                  X                                       |      1     |
      Eosinophilic Focus, Multiple         |                         X                                                |      1     |
      Fatty Change, Diffuse                |                                  1                                       |      1  1.0|
      Fatty Change, Focal                  |                      1                                                   |      1  1.0|
      Hepatocyte, Multinucleate            |                      1  1        1                                       |      3  1.0|
      Inflammation                         |    2  2  2           1  1  2  1  2                                       |      8  1.6|
      Mixed Cell Focus                     |       X                                                                  |      1     |
      Mixed Cell Focus, Multiple           |    X     X           X  X  X  X  X                                       |      7     |
      Necrosis                             |       1                                                                  |      1  1.0|
      Pigmentation                         |    2  2  2           1  1  2  2  2                                       |      8  1.8|
      Toxic Hepatopathy                    |    1     1                    1  2                                       |      4  1.3|
      Bile Duct, Hyperplasia               |    1     1                    1  1                                       |      4  1.0|
      Hepatocyte, Hypertrophy              |    1  1  2           1  1  1  2  3                                       |      8  1.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +           +  +  +  +  +                                       |   8        |
      Acinus, Vacuolization Cytoplasmic    |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +           +  +  +  +  +                                       |   8        |
      Hyperplasia                          |                         2        3                                       |      2  2.5|
      Hypertrophy                          |       1  1              1  1     2                                       |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +                                                               |   2        |
      Follicular Cell, Hypertrophy         |       2  1                                                               |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |      A     |
    550                                    | 0| 1| 1| 2| 3| 3| 5| 9| 9| 9| 9| 9| 9|                                   |      L     |
    NG/KG                                  | 8| 7| 8| 0| 3| 6| 4| 1| 2| 3| 4| 5| 8|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +           +  +  +  +  +                                       |   8        |
      Atrophy                              |    4  4  4           4  4  4  4                                          |      7  4.0|
      Cyst                                 |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |                         +                                                |   1        |
      Infarct                              |                         3                                                |      1  3.0|
      Pigmentation                         |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +           +  +  +  +  +                                       |   8        |
      Atrophy                              |    4  3  4           3  3  2  3  4                                       |      8  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +           +  +  +  +  +                                       |   8        |
      Infiltration Cellular, Histiocyte    |    1     1                    1                                          |      3  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |    1                          1                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |      A     |
    550                                    | 0| 1| 1| 2| 3| 3| 5| 9| 9| 9| 9| 9| 9|                                   |      L     |
    NG/KG                                  | 8| 7| 8| 0| 3| 6| 4| 1| 2| 3| 4| 5| 8|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                   |      A     |
    1000                                   | 4| 4| 4| 4| 5| 6| 6| 0| 1| 1| 1| 2| 4|                                   |      L     |
    NG/KG                                  | 6| 7| 8| 9| 0| 2| 8| 3| 2| 3| 4| 8| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +           +  +  +                                          |   8        |
      Basophilic Focus                     | X        X                                                               |      2     |
      Eosinophilic Focus, Multiple         | X                          X  X                                          |      3     |
      Fatty Change, Diffuse                | 1  1  1  1  1           1  1  1                                          |      8  1.0|
      Hepatocyte, Multinucleate            | 3  2  2  2  1           2  2  2                                          |      8  2.0|
      Inflammation                         | 1  2  1  2  1           2  2  2                                          |      8  1.6|
      Mixed Cell Focus, Multiple           | X  X  X  X  X           X  X  X                                          |      8     |
      Pigmentation                         | 3  2  2  3  2           2  2  3                                          |      8  2.4|
      Toxic Hepatopathy                    | 3  2  2  4  1           2  3  3                                          |      8  2.5|
      Vacuolization Cytoplasmic            | 1                                                                        |      1  1.0|
      Bile Duct, Hyperplasia               | 2  1  1  2                 1  1                                          |      6  1.3|
      Hepatocyte, Hypertrophy              | 4  2  3  3  2           2  3  3                                          |      8  2.8|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +           +  +  +                                          |   8        |
      Inflammation, Chronic Active         |          1                                                               |      1  1.0|
      Acinus, Atrophy                      |          1                                                               |      1  1.0|
      Acinus, Vacuolization Cytoplasmic    | 1  1     1              1  1  1                                          |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +           +  +  +                                          |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +           +  +  +                                          |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +           +  +  +                                          |   8        |
      Atrophy                              |       2                                                                  |      1  2.0|
      Degeneration, Cystic                 |       2                       1                                          |      2  1.5|
      Hyperplasia                          |       2  2                    3                                          |      3  2.3|
      Hypertrophy                          | 1     3  1                 2  2                                          |      5  1.8|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                   |      A     |
    1000                                   | 4| 4| 4| 4| 5| 6| 6| 0| 1| 1| 1| 2| 4|                                   |      L     |
    NG/KG                                  | 6| 7| 8| 9| 0| 2| 8| 3| 2| 3| 4| 8| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +           +  +  +                                          |   8        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +           +  +  +                                          |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +           +  +  +                                          |   8        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +           +  +  +                                          |   8        |
      Follicular Cell, Hypertrophy         | 1  1     2                 1  1                                          |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +           +  +  +                                          |   8        |
      Atrophy                              | 4  4  4  4              4  4  3                                          |      7  3.9|
      Cyst                                 |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +           +  +  +                                          |   8        |
      Inflammation, Suppurative            |                               2                                          |      1  2.0|
      Metaplasia, Squamous                 | 2  1  3  2              1  1  4                                          |      7  2.0|
      Cervix, Cyst                         |          3                                                               |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                            3                                             |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +           +  +  +                                          |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +           +  +  +                                          |   8        |
      Pigmentation                         | 1  1  1  1  1           1  1  1                                          |      8  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M           +  +  +                                          |   7        |
      Atrophy                              | 4  4  4  4              4  2  4                                          |      7  3.7|
 _____________________________________________________________________________________________________________________|            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:42:03    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                   |      A     |
    1000                                   | 4| 4| 4| 4| 5| 6| 6| 0| 1| 1| 1| 2| 4|                                   |      L     |
    NG/KG                                  | 6| 7| 8| 9| 0| 2| 8| 3| 2| 3| 4| 8| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +           +  +  +                                          |   8        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +           +  +  +                                          |   8        |
      Infiltration Cellular, Histiocyte    |    1  1  1  1           1  1                                             |      6  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |    1  1  1  1           1  1                                             |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------