National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4901

TDMS Study 96007-01 Pathology Tables

NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:44:51

                                                          53 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57465-28-8

       Lock Date:  01/09/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     02/25/99 - 02/26/99

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    10 NG/KG
                               Include 003    30 NG/KG
                               Include 004    100     NG/KG
                               Include 005    175     NG/KG
                               Include 006    300     NG/KG
                               Include 007    550     NG/KG
                               Include 008    1000    NG/KG


























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:44:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      10 NG/KG     30 NG/KG     100          175          300          
                                                                                             NG/KG        NG/KG        NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           48           98           98           98           98           
                                                                                                                                    
  Scheduled Sacrifice                                 13           15           13           13           13           13           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8            8            8            8            8            8           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (8)          (8)          (8)          (8)          (8)          
      Basophilic Focus                                 2            2                         1            2                        
      Cholangiofibrosis                                                                       1 [1.0]                               
      Clear Cell Focus                                                                                                  1           
      Clear Cell Focus, Multiple                                                                                        1           
      Eosinophilic Focus                                                                                   1                        
      Eosinophilic Focus, Multiple                                                                         1                        
      Fatty Change, Diffuse                                                                                2 [1.0]                  
      Hepatocyte, Multinucleate                                                                                         1 [1.0]     
      Inflammation                                     8 [1.1]      8 [1.0]      8 [1.1]      8 [1.0]      8 [1.1]      8 [1.3]     
      Mixed Cell Focus                                 3            3            1                         3            2           
      Mixed Cell Focus, Multiple                       1            2            2            6            3            4           
      Necrosis                                         1 [2.0]                                                                      
      Pigmentation                                                               3 [1.0]      8 [1.0]      7 [1.1]      8 [1.3]     
      Toxic Hepatopathy                                                                                    1 [1.0]                  
      Bile Duct, Cyst                                                                                                   1 [2.0]     
      Bile Duct, Hyperplasia                                                                                            1 [1.0]     
      Hepatocyte, Hypertrophy                                       3 [1.0]      2 [1.0]      5 [1.2]      6 [1.0]      7 [1.0]     
   Pancreas                                           (8)          (8)          (7)          (8)          (8)          (8)          
      Inflammation, Chronic Active                                                                                      1 [1.0]     
      Acinus, Atrophy                                                                                                   1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (8)          (8)          (8)          (8)          (8)          (8)          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:44:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      10 NG/KG     30 NG/KG     100          175          300          
                                                                                             NG/KG        NG/KG        NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Degeneration, Cystic                                                                                              1 [2.0]     
      Hyperplasia                                                   1 [2.0]      1 [1.0]      3 [1.3]      1 [1.0]      1 [2.0]     
      Hypertrophy                                      5 [1.4]      6 [1.7]      3 [1.0]      3 [1.0]      1 [1.0]      4 [1.5]     
      Vacuolization Cytoplasmic                                                               1 [1.0]      1 [1.0]                  
   Pituitary Gland                                    (8)                                                                           
      Pars Distalis, Hyperplasia                       2 [1.5]                                                                      
   Thyroid Gland                                      (8)          (3)          (1)          (3)          (3)          (3)          
      C-Cell, Hyperplasia                              2 [1.5]                                                                      
      Follicular Cell, Hypertrophy                     1 [1.0]      3 [1.3]      1 [1.0]      3 [1.0]      3 [1.0]      3 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)          (8)          (8)          (8)          (8)          (8)          
      Atrophy                                          8 [4.0]      7 [4.0]      7 [4.0]      8 [4.0]      6 [4.0]      8 [4.0]     
      Cyst                                                          1 [3.0]                                                         
   Uterus                                             (8)                       (2)                                    (2)          
      Inflammation, Suppurative                        3 [1.0]                   2 [1.5]                                2 [2.0]     
      Metaplasia, Squamous                             8 [2.8]                   1 [2.0]                                2 [3.0]     
      Endometrium, Hyperplasia, Cystic                                           2 [3.5]                                1 [4.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (8)                                                                           
      Pigmentation                                     8 [1.0]                                                                      
   Thymus                                             (8)          (8)          (8)          (8)          (7)          (8)          
      Atrophy                                          7 [2.0]      5 [2.2]      6 [2.0]      5 [2.2]      5 [2.2]      7 [2.4]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (8)                                    (1)          (2)                       
      Galactocele                                      1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:44:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      10 NG/KG     30 NG/KG     100          175          300          
                                                                                             NG/KG        NG/KG        NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (8)          (8)          (8)          (8)          (8)          
      Infiltration Cellular, Histiocyte                3 [1.0]      4 [1.0]      6 [1.0]      5 [1.0]      4 [1.0]      2 [1.0]     
      Inflammation, Chronic Active                     1 [3.0]                                1 [2.0]                               
      Alveolar Epithelium, Metaplasia, Bronchiolar                                                         1 [1.0]      1 [1.0]     
      Interstitium, Inflammation                                                                           1 [1.0]                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:44:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   550          1000                                                             
                                                      NG/KG        NG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98                                                               
                                                                                                                                    
  Scheduled Sacrifice                                 13           13                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8            8                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (8)                                                              
      Basophilic Focus                                 1            2                                                               
      Cholangiofibrosis                                1 [2.0]                                                                      
      Clear Cell Focus                                 1                                                                            
      Eosinophilic Focus, Multiple                     1            3                                                               
      Fatty Change, Diffuse                            1 [1.0]      8 [1.0]                                                         
      Fatty Change, Focal                              1 [1.0]                                                                      
      Hepatocyte, Multinucleate                        3 [1.0]      8 [2.0]                                                         
      Inflammation                                     8 [1.6]      8 [1.6]                                                         
      Mixed Cell Focus                                 1                                                                            
      Mixed Cell Focus, Multiple                       7            8                                                               
      Necrosis                                         1 [1.0]                                                                      
      Pigmentation                                     8 [1.8]      8 [2.4]                                                         
      Toxic Hepatopathy                                4 [1.3]      8 [2.5]                                                         
      Vacuolization Cytoplasmic                                     1 [1.0]                                                         
      Bile Duct, Hyperplasia                           4 [1.0]      6 [1.3]                                                         
      Hepatocyte, Hypertrophy                          8 [1.5]      8 [2.8]                                                         
   Pancreas                                           (8)          (8)                                                              
      Inflammation, Chronic Active                                  1 [1.0]                                                         
      Acinus, Atrophy                                               1 [1.0]                                                         
      Acinus, Vacuolization Cytoplasmic                1 [1.0]      6 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (8)          (8)                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:44:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   550          1000                                                             
                                                      NG/KG        NG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Atrophy                                                       1 [2.0]                                                         
      Degeneration, Cystic                                          2 [1.5]                                                         
      Hyperplasia                                      2 [2.5]      3 [2.3]                                                         
      Hypertrophy                                      5 [1.2]      5 [1.8]                                                         
   Thyroid Gland                                      (2)          (8)                                                              
      Follicular Cell, Hypertrophy                     2 [1.5]      5 [1.2]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)          (8)                                                              
      Atrophy                                          7 [4.0]      7 [3.9]                                                         
      Cyst                                             1 [2.0]      1 [2.0]                                                         
   Uterus                                                          (8)                                                              
      Inflammation, Suppurative                                     1 [2.0]                                                         
      Metaplasia, Squamous                                          7 [2.0]                                                         
      Cervix, Cyst                                                  1 [3.0]                                                         
      Endometrium, Hyperplasia, Cystic                              1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (1)          (8)                                                              
      Infarct                                          1 [3.0]                                                                      
      Pigmentation                                     1 [1.0]      8 [1.0]                                                         
   Thymus                                             (8)          (7)                                                              
      Atrophy                                          8 [3.3]      7 [3.7]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (1)          (8)                                                              
      Hyperplasia                                                   1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:44:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   550          1000                                                             
                                                      NG/KG        NG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (8)                                                              
      Infiltration Cellular, Histiocyte                3 [1.0]      6 [1.0]                                                         
      Alveolar Epithelium, Metaplasia, Bronchiolar     2 [1.0]      6 [1.0]                                                         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.