National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4927

TDMS Study 96007-01 Pathology Tables

NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03
Route: GAVAGE                                                                                                     Time: 11:43:31

                                                         FINAL #3/RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57465-28-8

       Lock Date:  01/09/01

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25018 Dosing Accident
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 NG/KG
                               Include 003    30 NG/KG
                               Include 004    100     NG/KG
                               Include 005    175     NG/KG
                               Include 006    300     NG/KG
                               Include 007    550     NG/KG
                               Include 008    1000    NG/KG
                               Include 009    1000 NG/KG/STOP

























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      30 NG/KG     100          175          300          550             
                                                                             NG/KG        NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          98           98           98           98           98           98           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           18           21           19           27           18           
    Natural Death                                     10            9            6           11            9           12           
    Accidently Killed                                  1            3                                                               
    Dosing Accident                                    2                                      1            1                        
  Survivors                                                                                                                         
    Natural Death                                                   1            1                                                  
    Terminal Sacrifice                                15           24           25           22           16           23           
                                                                                                                                    
  Animals Examined Microscopically                    53           55           53           53           53           53           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (52)         (55)         (53)         (53)         (53)         (51)         
      Serosa, Carcinoma, Metastatic, Uterus                         1 (2%)                                                          
   Intestine Large, Rectum                            (52)         (55)         (53)         (52)         (53)         (52)         
   Intestine Small, Duodenum                          (52)         (55)         (52)         (53)         (53)         (51)         
   Intestine Small, Jejunum                           (52)         (54)         (53)         (53)         (53)         (51)         
      Leiomyosarcoma                                                             2 (4%)                                             
      Serosa, Carcinoma, Metastatic, Uterus                         1 (2%)                                                          
   Intestine Small, Ileum                             (52)         (54)         (52)         (51)         (53)         (52)         
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Serosa, Carcinoma, Metastatic, Uterus                         1 (2%)                                                          
   Liver                                              (53)         (55)         (53)         (53)         (53)         (51)         
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Cholangiocarcinoma                                                         1 (2%)                    5 (9%)       2 (4%)      
      Cholangiocarcinoma, Multiple                                                                                      4 (8%)      
      Cholangioma                                                                                                       1 (2%)      
      Hepatocellular Carcinoma                                                                1 (2%)                                
      Hepatocellular Adenoma                           1 (2%)       2 (4%)       1 (2%)                    2 (4%)       4 (8%)      
      Schwannoma Malignant, Metastatic, Heart                                    1 (2%)                                             
   Mesentery                                          (1)                       (4)          (2)          (7)          (13)         
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (25%)                                            
      Sarcoma, Metastatic, Kidney                                                                                       1 (8%)      
      Sarcoma Stromal, Metastatic, Uterus                                                                               1 (8%)      
   Oral Mucosa                                        (1)          (1)          (3)          (4)          (2)          (6)          
      Gingival, Squamous Cell Carcinoma                             1 (100%)     1 (33%)      1 (25%)      2 (100%)     2 (33%)     
   Pancreas                                           (51)         (55)         (53)         (53)         (53)         (52)         
      Sarcoma Stromal, Metastatic, Uterus                                                                               1 (2%)      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      30 NG/KG     100          175          300          550             
                                                                             NG/KG        NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Acinus, Adenoma                                  1 (2%)                                              2 (4%)                   
      Acinus, Carcinoma                                                                       1 (2%)                                
   Salivary Glands                                    (51)         (54)         (53)         (51)         (52)         (51)         
      Carcinoma                                                                                            1 (2%)                   
   Stomach, Forestomach                               (52)         (55)         (53)         (53)         (53)         (51)         
      Serosa, Carcinoma, Metastatic, Uterus                         1 (2%)                                                          
   Stomach, Glandular                                 (51)         (53)         (53)         (53)         (53)         (51)         
      Schwannoma Malignant, Metastatic, Heart                                    1 (2%)                                             
      Serosa, Carcinoma, Metastatic, Uterus                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (53)         (55)         (53)         (53)         (53)         (53)         
   Heart                                              (52)         (54)         (53)         (53)         (53)         (51)         
      Schwannoma Benign                                                                                    1 (2%)                   
      Schwannoma Malignant                                          1 (2%)       2 (4%)                    2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (52)         (55)         (53)         (53)         (53)         (52)         
      Adenoma                                                       1 (2%)       1 (2%)                                 1 (2%)      
      Carcinoma                                                     1 (2%)                                 1 (2%)                   
      Schwannoma Malignant, Metastatic, Heart                                    1 (2%)                                             
   Adrenal Medulla                                    (52)         (55)         (53)         (53)         (53)         (52)         
      Pheochromocytoma Malignant                                                 1 (2%)       1 (2%)                    1 (2%)      
      Pheochromocytoma Complex                                                                             1 (2%)                   
      Pheochromocytoma Benign                          8 (15%)      3 (5%)       4 (8%)       2 (4%)       2 (4%)       4 (8%)      
      Schwannoma Malignant, Metastatic, Heart                                    1 (2%)                                             
   Islets, Pancreatic                                 (52)         (54)         (53)         (53)         (53)         (52)         
      Adenoma                                                       2 (4%)                    1 (2%)                                
      Carcinoma                                                                  1 (2%)                                             
   Parathyroid Gland                                  (47)         (50)         (48)         (46)         (49)         (47)         
      Adenoma                                                       1 (2%)                                              1 (2%)      
   Pituitary Gland                                    (51)         (54)         (53)         (53)         (53)         (53)         
      Sarcoma, Metastatic, Brain                                    1 (2%)                                                          
      Pars Distalis, Adenoma                          14 (27%)     18 (33%)     20 (38%)     16 (30%)     22 (42%)     13 (25%)     
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                           1 (2%)      
      Pars Distalis, Carcinoma                                                                1 (2%)                    1 (2%)      
      Pars Intermedia, Adenoma                         1 (2%)       2 (4%)       1 (2%)                                             
   Thyroid Gland                                      (52)         (55)         (52)         (51)         (52)         (50)         
      Bilateral, C-Cell, Adenoma                       3 (6%)       4 (7%)       3 (6%)       2 (4%)       3 (6%)       2 (4%)      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      30 NG/KG     100          175          300          550             
                                                                             NG/KG        NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Adenoma                                 12 (23%)     11 (20%)     12 (23%)     11 (22%)      9 (17%)     10 (20%)     
      C-Cell, Carcinoma                                             1 (2%)       2 (4%)                                 2 (4%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                                          (1)          
      Carcinoma                                                                                                         1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (52)         (54)         (53)         (52)         (52)         (52)         
      Cystadenoma                                                                                                       1 (2%)      
      Granulosa Cell Tumor Benign                                                             1 (2%)                                
      Granulosa-Theca Tumor Malignant                                            1 (2%)                                             
      Sarcoma Stromal, Metastatic, Uterus                                                                  1 (2%)                   
   Uterus                                             (52)         (55)         (53)         (52)         (53)         (52)         
      Adenoma                                                                                                           1 (2%)      
      Carcinoma                                                     3 (5%)       1 (2%)       1 (2%)                    1 (2%)      
      Hemangiosarcoma                                                                         1 (2%)                                
      Polyp Stromal                                    4 (8%)       5 (9%)       7 (13%)      3 (6%)       8 (15%)      5 (10%)     
      Sarcoma Stromal                                                                         1 (2%)       1 (2%)       2 (4%)      
      Sarcoma Stromal, Multiple                                                               1 (2%)                                
      Schwannoma Malignant                                                                                              1 (2%)      
      Squamous Cell Papilloma                                                    1 (2%)                                 1 (2%)      
      Cervix, Sarcoma Stromal                                                                              1 (2%)                   
      Cervix, Schwannoma Malignant                                                                         1 (2%)       1 (2%)      
   Vagina                                             (1)                       (1)                       (1)                       
      Sarcoma                                          1 (100%)                                                                     
      Sarcoma Stromal, Metastatic, Uterus                                                                  1 (100%)                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (55)         (53)         (53)         (53)         (53)         
   Lymph Node                                         (2)          (6)          (6)          (6)          (4)          (7)          
      Lumbar, Sarcoma Stromal, Metastatic, Uterus                                                                       1 (14%)     
      Mediastinal, Carcinoma, Metastatic, Islets,                                                                                   
           Pancreatic                                                            1 (17%)                                            
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                                                                                         1 (14%)     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      30 NG/KG     100          175          300          550             
                                                                             NG/KG        NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Renal, Nephroblastoma, Metastatic, Kidney        1 (50%)                                                                      
   Lymph Node, Mandibular                             (52)         (53)         (51)         (51)         (52)         (51)         
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Lymph Node, Mesenteric                             (52)         (54)         (52)         (52)         (53)         (51)         
      Hemangiosarcoma                                  1 (2%)                                                                       
   Spleen                                             (52)         (55)         (52)         (53)         (53)         (52)         
      Sarcoma Stromal, Metastatic, Uterus                                                                               1 (2%)      
      Schwannoma Malignant, Metastatic, Heart                                    1 (2%)                                             
      Capsule, Carcinoma, Metastatic, Uterus                        1 (2%)                                                          
   Thymus                                             (50)         (52)         (46)         (48)         (41)         (49)         
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (52)         (55)         (53)         (53)         (53)         (52)         
      Adenoma                                          2 (4%)                    2 (4%)                    1 (2%)                   
      Carcinoma                                        5 (10%)      6 (11%)      9 (17%)      4 (8%)                    1 (2%)      
      Carcinoma, Multiple                              1 (2%)       1 (2%)                    1 (2%)                                
      Fibroadenoma                                    18 (35%)     17 (31%)     21 (40%)     21 (40%)     26 (49%)     24 (46%)     
      Fibroadenoma, Multiple                          21 (40%)     14 (25%)     14 (26%)     17 (32%)     13 (25%)      5 (10%)     
   Skin                                               (52)         (55)         (53)         (53)         (53)         (53)         
      Fibroma                                          1 (2%)       1 (2%)                                                          
      Fibrous Histiocytoma                                                                                 1 (2%)       1 (2%)      
      Keratoacanthoma                                  1 (2%)                    1 (2%)                                             
      Squamous Cell Carcinoma                                                                                           1 (2%)      
      Subcutaneous Tissue, Fibroma, Multiple                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (53)         (55)         (53)         (53)         (53)         (53)         
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (100%)                                           
      Rhabdomyosarcoma                                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      30 NG/KG     100          175          300          550             
                                                                             NG/KG        NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (55)         (53)         (53)         (53)         (53)         
      Astrocytoma Malignant                            2 (4%)                                              1 (2%)                   
      Carcinoma, Metastatic, Pituitary Gland                                                  1 (2%)                    1 (2%)      
      Medulloblastoma Mal                                                        1 (2%)                    1 (2%)                   
      Oligodendroglioma Malignant                      1 (2%)                                                                       
      Meninges, Sarcoma                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (55)         (53)         (53)         (53)         (51)         
      Adenocarcinoma, Mucinous                                                                                          1 (2%)      
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                 1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                    1 (2%)       1 (2%)                                
      Cystic Keratinizing Epithelioma                                                                      1 (2%)       3 (6%)      
      Cystic Keratinizing Epithelioma, Multiple                                                                         8 (16%)     
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
      Sarcoma, Metastatic, Kidney                                                                                       1 (2%)      
      Sarcoma Stromal, Metastatic, Uterus                                                                               1 (2%)      
      Schwannoma Malignant, Metastatic, Heart                                    1 (2%)                                             
      Squamous Cell Carcinoma                                                                                           1 (2%)      
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                    1 (2%)                                                          
      Mediastinum, Carcinoma, Metastatic, Mammary                                                                                   
          Gland                                                                               1 (2%)                                
   Nose                                               (53)         (54)         (52)         (53)         (52)         (53)         
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Trachea                                            (53)         (55)         (53)         (53)         (53)         (52)         
      Peritracheal Tissue, Schwannoma Malignant,                                                                                    
           Metastatic, Heart                                                                               1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      30 NG/KG     100          175          300          550             
                                                                             NG/KG        NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (55)         (53)         (53)         (53)         (52)         
      Hemangiosarcoma                                  1 (2%)                                                                       
      Nephroblastoma                                   1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Schwannoma Malignant, Metastatic, Heart                                    1 (2%)                                             
      Stromal Nephroma                                              1 (2%)                    1 (2%)       1 (2%)       1 (2%)      
      Transitional Epithelium, Carcinoma                                                                                1 (2%)      
   Urinary Bladder                                    (51)         (54)         (53)         (52)         (52)         (52)         
      Serosa, Carcinoma, Metastatic, Uterus                         1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(53)        *(55)        *(53)        *(53)        *(53)        *(53)         
      Leukemia Granulocytic                                         1 (2%)                                                          
      Lymphoma Malignant                                            2 (4%)                    2 (4%)       1 (2%)       1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      30 NG/KG     100          175          300          550             
                                                                             NG/KG        NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          51          51          47          49          50               
     Total Primary Neoplasms                          103         104         113          93         110         111               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45          45          48          45          46          45               
     Total Benign Neoplasms                            89          81          89          75          90          85               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              13          19          18          15          16          23               
     Total Malignant Neoplasms                         14          23          24          18          20          26               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           3           3           2           4               
     Total Metastatic Neoplasm                          6           9          14           4           3           9               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                1000         1000 NG/                                                            
                                                   NG/KG        KG/STOP                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          98           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                     12            6                                                               
    Moribund Sacrifice                                34           15                                                               
    Dosing Accident                                                 1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                 7           28                                                               
                                                                                                                                    
  Animals Examined Microscopically                    53           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (53)         (50)                                                             
   Intestine Small, Duodenum                          (53)         (50)                                                             
   Intestine Small, Jejunum                           (53)         (50)                                                             
   Liver                                              (53)         (50)                                                             
      Cholangiocarcinoma                               7 (13%)      2 (4%)                                                          
      Cholangiocarcinoma, Multiple                    15 (28%)                                                                      
      Cholangioma                                      1 (2%)                                                                       
      Hepatocellular Adenoma                           6 (11%)                                                                      
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
      Hepatocholangioma                                2 (4%)                                                                       
      Hepatocholangioma, Multiple                      1 (2%)                                                                       
   Mesentery                                          (11)                                                                          
   Oral Mucosa                                        (11)         (6)                                                              
      Gingival, Squamous Cell Carcinoma                7 (64%)      2 (33%)                                                         
   Pancreas                                           (51)         (48)                                                             
      Acinus, Carcinoma                                1 (2%)                                                                       
   Salivary Glands                                    (51)         (49)                                                             
   Stomach, Forestomach                               (53)         (50)                                                             
   Stomach, Glandular                                 (53)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (53)         (50)                                                             
   Heart                                              (51)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                1000         1000 NG/                                                            
                                                   NG/KG        KG/STOP                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (53)         (50)                                                             
      Adenoma                                          2 (4%)       2 (4%)                                                          
      Carcinoma                                        2 (4%)       1 (2%)                                                          
   Adrenal Medulla                                    (53)         (50)                                                             
      Pheochromocytoma Benign                                       2 (4%)                                                          
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (51)         (50)                                                             
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (46)         (44)                                                             
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (53)         (48)                                                             
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                       1 (2%)                                                                       
      Pars Distalis, Adenoma                           6 (11%)     17 (35%)                                                         
   Thyroid Gland                                      (48)         (47)                                                             
      Adenoma                                          1 (2%)                                                                       
      Bilateral, C-Cell, Adenoma                                    5 (11%)                                                         
      C-Cell, Adenoma                                  9 (19%)     11 (23%)                                                         
      C-Cell, Carcinoma                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (53)         (50)                                                             
      Granulosa-Theca Tumor Benign                                  1 (2%)                                                          
   Uterus                                             (53)         (50)                                                             
      Adenoma                                                       1 (2%)                                                          
      Adenoma, Multiple                                1 (2%)                                                                       
      Polyp Stromal                                    4 (8%)       5 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (50)                                                             
   Lymph Node                                         (12)         (2)                                                              
   Lymph Node, Mandibular                             (51)         (49)                                                             
   Lymph Node, Mesenteric                             (53)         (50)                                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                1000         1000 NG/                                                            
                                                   NG/KG        KG/STOP                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (52)         (50)                                                             
   Thymus                                             (44)         (43)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (50)                                                             
      Carcinoma                                        1 (2%)       4 (8%)                                                          
      Fibroadenoma                                    11 (21%)     15 (30%)                                                         
      Fibroadenoma, Multiple                                       13 (26%)                                                         
   Skin                                               (53)         (50)                                                             
      Keratoacanthoma                                  1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (53)         (50)                                                             
      Osteosarcoma                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (50)                                                             
      Astrocytoma Malignant                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (51)         (50)                                                             
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Adrenal Cortex            1 (2%)                                                                       
      Cystic Keratinizing Epithelioma                  5 (10%)                                                                      
      Cystic Keratinizing Epithelioma, Multiple       30 (59%)                                                                      
      Squamous Cell Carcinoma                          2 (4%)                                                                       
   Nose                                               (53)         (50)                                                             
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                1000         1000 NG/                                                            
                                                   NG/KG        KG/STOP                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (52)         (50)                                                             
      Optic Nerve, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Oral Mucosa                      1 (2%)                                                                       
   Harderian Gland                                    (52)         (50)                                                             
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (50)                                                             
      Nephroblastoma                                   2 (4%)                                                                       
      Stromal Nephroma                                 1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(53)        *(50)                                                             
      Leukemia Mononuclear                             1 (2%)                                                                       
      Lymphoma Malignant                               2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03  
Route: GAVAGE                                                                                                     Time: 11:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                1000         1000 NG/                                                            
                                                   NG/KG        KG/STOP                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          44                                                               
     Total Primary Neoplasms                          123          89                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          41                                                               
     Total Benign Neoplasms                            82          76                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          12                                                               
     Total Malignant Neoplasms                         41          13                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1                                                               
     Total Metastatic Neoplasm                          5           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.