National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5258

TDMS Study 96007-03 Pathology Tables

NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02
Route: GAVAGE                                                                                                     Time: 11:46:09

                                                          14 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1746-01-6

       Lock Date:  06/28/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     09/02/98 - 09/03/98

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    3 NG/KG
                               Include 003    10 NG/KG
                               Include 004    22 NG/KG
                               Include 005    46 NG/KG
                               Include 006    100     NG/KG































                                                              Page   1


NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 5| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4| 4| 5| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG/KG                                | 3| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 9|                          |      L     |
                                           | 2| 0| 1| 2| 3| 4| 5| 9| 0| 6| 7| 8| 9| 0| 9| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Inflammation                         |       1  1  1  1  2        1  1  1  1  1                                 |     10  1.1|
      Pigmentation                         |                                  1                                       |      1  1.0|
      Hepatocyte, Hypertrophy              |       1                                                                  |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Hypertrophy                          |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 5| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4| 4| 5| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG/KG                                | 3| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 9|                          |      L     |
                                           | 2| 0| 1| 2| 3| 4| 5| 9| 0| 6| 7| 8| 9| 0| 9| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Atrophy                              |                   3        3                                             |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Metaplasia, Squamous                 |                1                                                         |      1  1.0|
      Endometrium, Hyperplasia, Cystic     |       4     4  1                    4  4                                 |      5  3.4|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Pigmentation                         |       1  1  2  2  1        1  1  1  1  1                                 |     10  1.2|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 5| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4| 4| 5| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG/KG                                | 3| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 9|                          |      L     |
                                           | 2| 0| 1| 2| 3| 4| 5| 9| 0| 6| 7| 8| 9| 0| 9| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 4| 5| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |      A     |
    3 NG/KG                                | 2| 3| 3| 3| 3| 4| 4| 5| 6| 7| 7| 7| 7| 7| 8| 8|                          |      L     |
                                           | 7| 6| 7| 8| 9| 0| 3| 2| 9| 1| 2| 3| 4| 5| 0| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Inflammation                         |    1  1  1  1  1           1  1  1  1  1                                 |     10  1.0|
      Mixed Cell Focus                     |                X                    X                                    |      2     |
      Hepatocyte, Hypertrophy              |                            1                                             |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Hypertrophy                          |    1                                1                                    |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Follicular Cell, Hypertrophy         |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Atrophy                              |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 4| 5| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |      A     |
    3 NG/KG                                | 2| 3| 3| 3| 3| 4| 4| 5| 6| 7| 7| 7| 7| 7| 8| 8|                          |      L     |
                                           | 7| 6| 7| 8| 9| 0| 3| 2| 9| 1| 2| 3| 4| 5| 0| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    10 NG/KG                               | 2| 2| 2| 2| 3| 3| 4| 5| 6| 7| 7| 7| 7| 7| 8| 8|                          |      L     |
                                           | 6| 7| 8| 9| 0| 2| 3| 2| 9| 5| 6| 7| 8| 9| 0| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                 +  +  +  +  +                              |  10        |
      Inflammation                         |       1  1  1                 1  1  1  1  1                              |      8  1.0|
      Hepatocyte, Hypertrophy              |       2                       1     1  1                                 |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                 +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                 +  +  +  +  +                              |  10        |
      Hypertrophy                          |       2                                   1                              |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                 +  +  +  +  +                              |  10        |
      Follicular Cell, Hypertrophy         | 3                                   2     4                              |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                +                                       |   2        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                 +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    10 NG/KG                               | 2| 2| 2| 2| 3| 3| 4| 5| 6| 7| 7| 7| 7| 7| 8| 8|                          |      L     |
                                           | 6| 7| 8| 9| 0| 2| 3| 2| 9| 5| 6| 7| 8| 9| 0| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                 +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    22 NG/KG                               | 1| 3| 4| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9|                          |      L     |
                                           | 0| 8| 7| 6| 7| 8| 9| 0| 7| 9| 5| 6| 7| 8| 9| 0|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |          +  +  +  +  +           +  +  +  +  +                           |  10        |
      Inflammation                         |          1  2  1  1  1           1  1  1  1  1                           |     10  1.1|
      Mixed Cell Focus                     |                   X                                                      |      1     |
      Hepatocyte, Hypertrophy              |          1  1     1  1              1  1  1                              |      7  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |          +  +  +  +  +           +  +  +  +  +                           |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |          +  +  +  +  +           +  +  +  +  +                           |  10        |
      Hypertrophy                          |                                  2                                       |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +  +  +  +           +  +  +  +  +                           |  10        |
      Follicular Cell, Hypertrophy         |          3                             3  2  2                           |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +                                +  +                           |   3        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |          +  +  +  +  +           +  +  +  +  +                           |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 5| 5| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    22 NG/KG                               | 1| 3| 4| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9|                          |      L     |
                                           | 0| 8| 7| 6| 7| 8| 9| 0| 7| 9| 5| 6| 7| 8| 9| 0|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |          +  +  +  +  +           +  +  +  +  +                           |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    46 NG/KG                               | 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 6| 6| 7| 8|                          |      L     |
                                           | 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 1| 8| 3| 4|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
      Inflammation                         |    1  1  1  2  1  1  1  2  1  1                                          |     10  1.2|
      Mixed Cell Focus                     |                         X                                                |      1     |
      Hepatocyte, Hypertrophy              |    2  1  2  1  2  2  2  2  2  1                                          |     10  1.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
      Hypertrophy                          |             1                                                            |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
      Follicular Cell, Hypertrophy         |                4     1     3  3                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                   +  +                                                   |   2        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
      Atrophy                              |             2        1  1     1                                          |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    46 NG/KG                               | 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 6| 6| 7| 8|                          |      L     |
                                           | 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 1| 8| 3| 4|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
      Inflammation, Chronic                |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 4| 5| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                          |      A     |
    100                                    | 8| 9| 9| 9| 9| 9| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4|                          |      L     |
    NG/KG                                  | 2| 1| 2| 3| 4| 5| 5| 7| 0| 1| 2| 3| 4| 5| 9| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Fatty Change, Diffuse                |             1                 1                                          |      2  1.0|
      Inflammation                         |    1  1  2  1  2           1  1  1  1  1                                 |     10  1.2|
      Mixed Cell Focus                     |       X                          X                                       |      2     |
      Pigmentation                         |       1                                                                  |      1  1.0|
      Hepatocyte, Hypertrophy              |    1  2  2  3  3           2  2  4  2  2                                 |     10  2.3|
      Hepatocyte, Multinucleated           |          1     1                 1                                       |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Inflammation, Chronic Active         |       2                          1                                       |      2  1.5|
      Acinus, Atrophy                      |       2                          1                                       |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Follicular Cell, Hypertrophy         |    1  2  3  2  3           3  3     1  1                                 |      9  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 4| 5| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                          |      A     |
    100                                    | 8| 9| 9| 9| 9| 9| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4|                          |      L     |
    NG/KG                                  | 2| 1| 2| 3| 4| 5| 5| 7| 0| 1| 2| 3| 4| 5| 9| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Atrophy                              |                            3                                             |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Endometrium, Hyperplasia, Cystic     |                4           3        4  4                                 |      4  3.8|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Pigmentation                         |    1  1  1  2  1           1  2  1  1  1                                 |     10  1.2|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Atrophy                              |    2  2  2  1  2           1  2  1  1  2                                 |     10  1.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 11:46:09    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                          |            |
                                           | 5| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 4| 5| 5|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                          |      A     |
    100                                    | 8| 9| 9| 9| 9| 9| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4|                          |      L     |
    NG/KG                                  | 2| 1| 2| 3| 4| 5| 5| 7| 0| 1| 2| 3| 4| 5| 9| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.