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TDMS Study 96007-03 Pathology Tables

NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02
Route: GAVAGE                                                                                                     Time: 12:01:07

                                                          31 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1746-01-6

       Lock Date:  06/28/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     12/30/98 - 12/31/98

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    3 NG/KG
                               Include 003    10 NG/KG
                               Include 004    22 NG/KG
                               Include 005    46 NG/KG
                               Include 006    100     NG/KG































                                                              Page   1


NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG/KG                                | 1| 2| 2| 2| 2| 3| 4| 4| 6| 6| 6| 6| 7| 7| 8| 9|                          |      L     |
                                           | 5| 6| 7| 8| 9| 0| 5| 6| 6| 7| 8| 9| 0| 4| 5| 4|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
      Inflammation                         |    1  1  1  1  1           1  1  1  1                                    |      9  1.0|
      Mitotic Alteration                   |             2                                                            |      1  2.0|
      Mixed Cell Focus                     |          X                                                               |      1     |
      Mixed Cell Focus, Multiple           |                X              X                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
      Acinus, Atrophy                      |       1                             1                                    |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG/KG                                | 1| 2| 2| 2| 2| 3| 4| 4| 6| 6| 6| 6| 7| 7| 8| 9|                          |      L     |
                                           | 5| 6| 7| 8| 9| 0| 5| 6| 6| 7| 8| 9| 0| 4| 5| 4|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Ovary                                   |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
      Atrophy                              |    4  4  4  4  3        4     4  4  4                                    |      9  3.9|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
      Metaplasia, Squamous                 |    2  1  2  1           1     1  2  2                                    |      8  1.5|
      Endometrium, Hyperplasia, Cystic     |                            3                                             |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
      Pigmentation                         |    1  2  1  1  1        1  1  2  1  1                                    |     10  1.2|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
      Atrophy                              |             2                    2                                       |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
                                           |__________________________________________________________________________|____________|
   Skin                                    |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +        +  +  +  +  +                                    |  10        |
      Infiltration Cellular, Histiocyte    |             1                 1                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG/KG                                | 1| 2| 2| 2| 2| 3| 4| 4| 6| 6| 6| 6| 7| 7| 8| 9|                          |      L     |
                                           | 5| 6| 7| 8| 9| 0| 5| 6| 6| 7| 8| 9| 0| 4| 5| 4|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |      A     |
    3 NG/KG                                | 0| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 8| 9| 9|                          |      L     |
                                           | 1| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 6| 0| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
      Angiectasis                          |                         2                                                |      1  2.0|
      Hepatodiaphragmatic Nodule           |                            X                                             |      1     |
      Inflammation                         |    2  1  1  1  1  1  2     2  1                                          |      9  1.3|
      Mixed Cell Focus                     |    X  X        X                                                         |      3     |
      Mixed Cell Focus, Multiple           |             X     X  X     X                                             |      4     |
      Pigmentation                         |                            1                                             |      1  1.0|
      Hepatocyte, Hypertrophy              |          1  1                                                            |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
      Hypertrophy                          |                1           2                                             |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
      Follicular Cell, Hypertrophy         |    2           2           1                                             |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  |                +                                                         |   1        |
      Inflammation, Suppurative            |                2                                                         |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |      A     |
    3 NG/KG                                | 0| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 8| 9| 9|                          |      L     |
                                           | 1| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 6| 0| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
      Atrophy                              |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +  +  +                                          |  10        |
      Infiltration Cellular, Histiocyte    |          1        1     1                                                |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 3| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    10 NG/KG                               | 1| 3| 3| 3| 3| 4| 4| 5| 6| 8| 9| 9| 9| 9| 9| 9|                          |      L     |
                                           | 9| 6| 7| 8| 9| 0| 8| 1| 5| 1| 1| 2| 3| 4| 5| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Inflammation                         |    1  1  2  2  2              1  1  1  1  1                              |     10  1.3|
      Mixed Cell Focus                     |    X        X  X                                                         |      3     |
      Mixed Cell Focus, Multiple           |                                     X                                    |      1     |
      Pigmentation                         |    1  1  1  1  1              1     1     1                              |      8  1.0|
      Hepatocyte, Hypertrophy              |                                  1     1  1                              |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Acinus, Atrophy                      |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Hypertrophy                          |          1  2                    1                                       |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Follicular Cell, Hypertrophy         |                                  1     1  3                              |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Atrophy                              |    2        2                 2        1  1                              |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 3| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    10 NG/KG                               | 1| 3| 3| 3| 3| 4| 4| 5| 6| 8| 9| 9| 9| 9| 9| 9|                          |      L     |
                                           | 9| 6| 7| 8| 9| 0| 8| 1| 5| 1| 1| 2| 3| 4| 5| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Infiltration Cellular, Histiocyte    |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 4| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    22 NG/KG                               | 0| 1| 2| 2| 2| 2| 2| 6| 6| 7| 7| 7| 7| 7| 7| 9|                          |      L     |
                                           | 8| 3| 1| 2| 3| 4| 5| 6| 9| 1| 2| 3| 4| 5| 8| 1|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Inflammation                         |       2  1  2  2  1        1  1  2  1  2                                 |     10  1.5|
      Mixed Cell Focus                     |          X  X                                                            |      2     |
      Pigmentation                         |       1  1  1  1           1  1  1  1  1                                 |      9  1.0|
      Hepatocyte, Hypertrophy              |          1  1     1        1  1  2                                       |      6  1.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Degeneration, Cystic                 |                                        2                                 |      1  2.0|
      Hyperplasia                          |                2                                                         |      1  2.0|
      Hypertrophy                          |                               1  1     2                                 |      3  1.3|
      Necrosis                             |             1                                                            |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Follicular Cell, Hypertrophy         |                               1  1     2                                 |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Atrophy                              |       2     2     2           2     2  1                                 |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 4| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    22 NG/KG                               | 0| 1| 2| 2| 2| 2| 2| 6| 6| 7| 7| 7| 7| 7| 7| 9|                          |      L     |
                                           | 8| 3| 1| 2| 3| 4| 5| 6| 9| 1| 2| 3| 4| 5| 8| 1|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Infiltration Cellular, Histiocyte    |                                  1                                       |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 4| 3| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 3| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    46 NG/KG                               | 2| 2| 3| 3| 3| 3| 4| 4| 8| 8| 9| 9| 9| 9| 9| 9|                          |      L     |
                                           | 0| 9| 6| 7| 8| 9| 0| 3| 0| 6| 1| 2| 3| 4| 5| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Angiectasis                          |                2                                                         |      1  2.0|
      Inflammation                         |       2  1  2  1  2           2  1  1  1  2                              |     10  1.5|
      Mixed Cell Focus                     |             X  X              X                                          |      3     |
      Mixed Cell Focus, Multiple           |                                     X                                    |      1     |
      Pigmentation                         |       1  1  1  1  1           1  1  1  1  1                              |     10  1.0|
      Hepatocyte, Hypertrophy              |       2  1  1  1              2  1  1  1  2                              |      9  1.3|
      Hepatocyte, Multinucleated           |       1     1                 1  1        1                              |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Acinus, Atrophy                      |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Degeneration, Cystic                 |                                        2                                 |      1  2.0|
      Hypertrophy                          |       1                          1     2                                 |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Follicular Cell, Hypertrophy         |       2  1                       1  1                                    |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +  +           +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 4| 3| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 3| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    46 NG/KG                               | 2| 2| 3| 3| 3| 3| 4| 4| 8| 8| 9| 9| 9| 9| 9| 9|                          |      L     |
                                           | 0| 9| 6| 7| 8| 9| 0| 3| 0| 6| 1| 2| 3| 4| 5| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Atrophy                              |       1  2     2  2           2  3        2                              |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +  +           +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Pleura                                  |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 3| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 3| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|                          |      A     |
    100                                    | 0| 7| 7| 7| 7| 8| 8| 0| 1| 2| 2| 2| 2| 3| 3| 4|                          |      L     |
    NG/KG                                  | 8| 6| 7| 8| 9| 0| 8| 0| 9| 6| 7| 8| 9| 0| 4| 0|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Fatty Change, Diffuse                |    1  1  1  1              1        1                                    |      6  1.0|
      Inflammation                         |    2  2  1  2  1           2  2  2  2  2                                 |     10  1.8|
      Mixed Cell Focus                     |          X                 X     X                                       |      3     |
      Mixed Cell Focus, Multiple           |    X  X     X  X              X     X  X                                 |      7     |
      Necrosis                             |                               1                                          |      1  1.0|
      Pigmentation                         |    2  2  2  2  2           2  3  2  2  2                                 |     10  2.1|
      Toxic Hepatopathy                    |    2  2  1  2  2           2  2  2  2  3                                 |     10  2.0|
      Bile Duct, Hyperplasia               |                                        2                                 |      1  2.0|
      Hepatocyte, Hypertrophy              |    3  3  2  2  3           2  3  2  3  4                                 |     10  2.7|
      Hepatocyte, Multinucleated           |    2  1     2  2           2  2  3  2  2                                 |      9  2.0|
      Oval Cell, Hyperplasia               |                                        1                                 |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Acinus, Vacuolization Cytoplasmic    |    1     1  1              1           1                                 |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Hypertrophy                          |       1        1           1                                             |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 3| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 3| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|                          |      A     |
    100                                    | 0| 7| 7| 7| 7| 8| 8| 0| 1| 2| 2| 2| 2| 3| 3| 4|                          |      L     |
    NG/KG                                  | 8| 6| 7| 8| 9| 0| 8| 0| 9| 6| 7| 8| 9| 0| 4| 0|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Follicular Cell, Hypertrophy         |    1  2     3              1     1     3                                 |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Atrophy                              |             4  4           4  4  4  4  4                                 |      7  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Metaplasia, Squamous                 |             1                 1     1  1                                 |      4  1.0|
      Endometrium, Hyperplasia, Cystic     |       4                          4                                       |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Pigmentation                         |    1  1  1  1  1           2  1  1  2  1                                 |     10  1.2|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Atrophy                              |    3  3  3  3  4           3  3  3  3  3                                 |     10  3.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:01:07    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 4| 3| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 3| 4| 4|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|                          |      A     |
    100                                    | 0| 7| 7| 7| 7| 8| 8| 0| 1| 2| 2| 2| 2| 3| 3| 4|                          |      L     |
    NG/KG                                  | 8| 6| 7| 8| 9| 0| 8| 0| 9| 6| 7| 8| 9| 0| 4| 0|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +           +  +  +  +  +                                 |  10        |
      Infiltration Cellular, Histiocyte    |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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