Share This:
https://ntp.niehs.nih.gov/go/5278

TDMS Study 96007-03 Pathology Tables

NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:05:37

                                                          31 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1746-01-6

       Lock Date:  06/28/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     12/30/98 - 12/31/98

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    3 NG/KG
                               Include 003    10 NG/KG
                               Include 004    22 NG/KG
                               Include 005    46 NG/KG
                               Include 006    100     NG/KG




























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02    
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:05:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100          
                                                                                                                       NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98           98           98           98           98           
                                                                                                                                    
  Scheduled Sacrifice                                 16           16           16           16           16           16           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Angiectasis                                                   1 [2.0]                                1 [2.0]                  
      Fatty Change, Diffuse                                                                                             6 [1.0]     
      Hepatodiaphragmatic Nodule                                    1                                                               
      Inflammation                                     9 [1.0]      9 [1.3]     10 [1.3]     10 [1.5]     10 [1.5]     10 [1.8]     
      Mitotic Alteration                               1 [2.0]                                                                      
      Mixed Cell Focus                                 1            3            3            2            3            3           
      Mixed Cell Focus, Multiple                       2            4            1                         1            7           
      Necrosis                                                                                                          1 [1.0]     
      Pigmentation                                                  1 [1.0]      8 [1.0]      9 [1.0]     10 [1.0]     10 [2.1]     
      Toxic Hepatopathy                                                                                                10 [2.0]     
      Bile Duct, Hyperplasia                                                                                            1 [2.0]     
      Hepatocyte, Hypertrophy                                       2 [1.0]      3 [1.0]      6 [1.2]      9 [1.3]     10 [2.7]     
      Hepatocyte, Multinucleated                                                                           5 [1.0]      9 [2.0]     
      Oval Cell, Hyperplasia                                                                                            1 [1.0]     
   Pancreas                                           (10)         (10)         (10)         (10)         (10)         (10)         
      Acinus, Atrophy                                  2 [1.0]                   1 [1.0]                   1 [1.0]                  
      Acinus, Vacuolization Cytoplasmic                                                                                 5 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)         (10)         (10)         
      Degeneration, Cystic                                                                    1 [2.0]      1 [2.0]                  
      Hyperplasia                                                                             1 [2.0]                               
      Hypertrophy                                                   2 [1.5]      3 [1.3]      3 [1.3]      3 [1.3]      3 [1.0]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02    
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:05:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100          
                                                                                                                       NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Necrosis                                                                                1 [1.0]                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)         (10)         (10)         
      Follicular Cell, Hypertrophy                                  3 [1.7]      3 [1.7]      3 [1.3]      4 [1.3]      6 [1.8]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)                                                             (10)         
      Atrophy                                          9 [3.9]                                                          7 [4.0]     
   Uterus                                             (10)         (1)                                                 (10)         
      Inflammation, Suppurative                                     1 [2.0]                                                         
      Metaplasia, Squamous                             8 [1.5]                                                          4 [1.0]     
      Endometrium, Hyperplasia, Cystic                 1 [3.0]      1 [4.0]                                             2 [4.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                             (10)         
      Pigmentation                                    10 [1.2]                                                         10 [1.2]     
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                          2 [2.0]      1 [1.0]      5 [1.6]      6 [1.8]      7 [2.0]     10 [3.1]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02    
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:05:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100          
                                                                                                                       NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Infiltration Cellular, Histiocyte                2 [1.0]      3 [1.0]      1 [1.0]      1 [1.0]                   1 [1.0]     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------