National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5280

TDMS Study 96007-03 Pathology Tables

NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02
Route: GAVAGE                                                                                                     Time: 12:07:47

                                                          53 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1746-01-6

       Lock Date:  06/28/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     06/03/99 - 06/04/99

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    3 NG/KG
                               Include 003    10 NG/KG
                               Include 004    22 NG/KG
                               Include 005    46 NG/KG
                               Include 006    100     NG/KG





























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:07:47    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98           98           98           98           98           
                                                                                                                                    
  Scheduled Sacrifice                                 13           12           13           13           13           13           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8            8            8            8            8            8           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (8)          (8)          (8)          (8)          (8)          
      Basophilic Focus                                                           1 (13%)                                2 (25%)     
      Basophilic Focus, Multiple                                    1 (13%)                                             1 (13%)     
      Cholangiofibrosis                                                                                    1 (13%)      1 (13%)     
      Clear Cell Focus                                 2 (25%)                                                                      
      Fatty Change, Diffuse                                                                                2 (25%)      6 (75%)     
      Hepatodiaphragmatic Nodule                                                              1 (13%)                               
      Inflammation                                     8 (100%)     8 (100%)     8 (100%)     8 (100%)     8 (100%)     8 (100%)    
      Mixed Cell Focus                                 2 (25%)      1 (13%)                   2 (25%)      1 (13%)                  
      Mixed Cell Focus, Multiple                                    4 (50%)                   4 (50%)      6 (75%)      8 (100%)    
      Pigmentation                                                               5 (63%)      8 (100%)     8 (100%)     8 (100%)    
      Toxic Hepatopathy                                                          1 (13%)                   6 (75%)      8 (100%)    
      Bile Duct, Cyst                                                            1 (13%)                                            
      Bile Duct, Fibrosis                                                                                  1 (13%)      2 (25%)     
      Bile Duct, Hyperplasia                                                     1 (13%)      2 (25%)      3 (38%)      8 (100%)    
      Hepatocyte, Hypertrophy                                       4 (50%)      7 (88%)      8 (100%)     8 (100%)     8 (100%)    
      Hepatocyte, Multinucleated                                                                           2 (25%)      8 (100%)    
   Pancreas                                           (8)          (8)          (8)          (8)          (8)          (8)          
      Inflammation, Chronic Active                                                                                      2 (25%)     
      Acinus, Atrophy                                                                                                   2 (25%)     
      Acinus, Vacuolization Cytoplasmic                                                                                 7 (88%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (8)          (8)          (8)          (8)          (8)          (8)          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:07:47    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Degeneration, Cystic                             1 (13%)      1 (13%)      1 (13%)      2 (25%)                   1 (13%)     
      Hyperplasia                                      1 (13%)                                             3 (38%)      2 (25%)     
      Hypertrophy                                      5 (63%)      3 (38%)      4 (50%)      4 (50%)      5 (63%)      7 (88%)     
      Vacuolization Cytoplasmic                                     1 (13%)                                                         
   Pituitary Gland                                    (8)                       (1)                                    (7)          
      Cyst                                             1 (13%)                                                                      
   Thyroid Gland                                      (8)          (8)          (8)          (8)          (8)          (8)          
      Follicular Cell, Hypertrophy                                  1 (13%)      2 (25%)      2 (25%)      3 (38%)      5 (63%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)                                                              (7)          
      Atrophy                                          8 (100%)                                                         5 (71%)     
   Uterus                                             (8)                                    (1)                       (8)          
      Metaplasia, Squamous                             7 (88%)                                                          4 (50%)     
      Cervix, Cyst, Squamous                           1 (13%)                                                                      
      Endometrium, Hyperplasia, Cystic                 5 (63%)                                1 (100%)                  2 (25%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (8)                                                              (8)          
      Hyperplasia, Focal, Lymphoid                     1 (13%)                                                                      
      Pigmentation                                     8 (100%)                                                         8 (100%)    
   Thymus                                             (8)          (8)          (7)          (8)          (8)          (8)          
      Atrophy                                          4 (50%)      2 (25%)      3 (43%)      7 (88%)      8 (100%)     8 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (8)          (2)          (2)                                    (8)          
      Cyst                                             3 (38%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:07:47    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (8)          (8)          (8)          (8)          (8)          
      Infiltration Cellular, Histiocyte                3 (38%)      1 (13%)      2 (25%)      1 (13%)      4 (50%)      3 (38%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                                          (2)                                                 (1)          
      Cyst                                                          1 (50%)                                                         
      Inflammation, Chronic Active                                  1 (50%)                                                         
      Nephropathy                                                                                                       1 (100%)    
      Pelvis, Dilatation                                            1 (50%)                                             1 (100%)    
   Ureter                                                          (1)                                                 (1)          
      Mineralization                                                                                                    1 (100%)    
      Transitional Epithelium, Hyperplasia                          1 (100%)                                            1 (100%)    
   Urinary Bladder                                                 (1)                                                              
      Inflammation                                                  1 (100%)                                                        
      Transitional Epithelium, Hyperplasia                          1 (100%)                                                        
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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