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TDMS Study 96007-03 Pathology Tables

NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02
Route: GAVAGE                                                                                                     Time: 12:14:12

                                                          53 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1746-01-6

       Lock Date:  06/28/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     06/03/99 - 06/04/99

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    3 NG/KG
                               Include 003    10 NG/KG
                               Include 004    22 NG/KG
                               Include 005    46 NG/KG
                               Include 006    100     NG/KG































                                                              Page   1


NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 9| 8| 8| 8| 8| 8| 9| 8| 8| 8| 9| 9| 9|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG/KG                                | 0| 1| 1| 1| 1| 2| 3| 5| 5| 5| 6| 7| 9|                                   |      L     |
                                           | 8| 6| 7| 8| 9| 0| 3| 6| 7| 8| 5| 2| 0|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +     +  +  +                                             |   8        |
      Clear Cell Focus                     |                         X  X                                             |      2     |
      Inflammation                         |    1  1  1  1  1     1  1  1                                             |      8  1.0|
      Mixed Cell Focus                     |    X                       X                                             |      2     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +     +  +  +                                             |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +     +  +  +                                             |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +     +  +  +                                             |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +     +  +  +                                             |   8        |
      Degeneration, Cystic                 |             1                                                            |      1  1.0|
      Hyperplasia                          |    1                                                                     |      1  1.0|
      Hypertrophy                          |       1  2  2        2  1                                                |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +  +     +  +  +                                             |   8        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +     +  +  +                                             |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +     +  +  +                                             |   8        |
      Cyst                                 |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +     +  +  +                                             |   8        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 9| 8| 8| 8| 8| 8| 9| 8| 8| 8| 9| 9| 9|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG/KG                                | 0| 1| 1| 1| 1| 2| 3| 5| 5| 5| 6| 7| 9|                                   |      L     |
                                           | 8| 6| 7| 8| 9| 0| 3| 6| 7| 8| 5| 2| 0|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +     +  +  +                                             |   8        |
      Atrophy                              |    4  4  4  4  4     4  4  4                                             |      8  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +     +  +  +                                             |   8        |
      Metaplasia, Squamous                 |    4  2     2  2     1  3  3                                             |      7  2.4|
      Cervix, Cyst, Squamous               |                            3                                             |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |       2  2  2        2  2                                                |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |    +  +  +  +  +     +  +  +                                             |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +     +  +  +                                             |   8        |
      Hyperplasia, Focal, Lymphoid         |    2                                                                     |      1  2.0|
      Pigmentation                         |    1  2  2  1  2     2  2  2                                             |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +     +  +  +                                             |   8        |
      Atrophy                              |    2        2           2  2                                             |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +     +  +  +                                             |   8        |
      Cyst                                 |             2  1        3                                                |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +     +  +  +                                             |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 9| 8| 8| 8| 8| 8| 9| 8| 8| 8| 9| 9| 9|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG/KG                                | 0| 1| 1| 1| 1| 2| 3| 5| 5| 5| 6| 7| 9|                                   |      L     |
                                           | 8| 6| 7| 8| 9| 0| 3| 6| 7| 8| 5| 2| 0|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Infiltration Cellular, Histiocyte    |                1     1  1                                                |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                      |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                      |            |
                                           | 9| 9| 9| 9| 8| 8| 8| 8| 8| 8| 8| 8|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    3 NG/KG                                | 1| 3| 3| 6| 8| 8| 8| 9| 9| 9| 9| 9|                                      |      L     |
                                           | 9| 2| 5| 7| 7| 8| 9| 1| 2| 3| 4| 5|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +  +  +  +  +  +  +  +                                       |   8        |
      Basophilic Focus, Multiple           |                      X                                                   |      1     |
      Inflammation                         |             1  1  1  1  1  1  1  1                                       |      8  1.0|
      Mixed Cell Focus                     |                            X                                             |      1     |
      Mixed Cell Focus, Multiple           |             X        X  X     X                                          |      4     |
      Hepatocyte, Hypertrophy              |             1  1     1           1                                       |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |             +  +  +  +  +  +  +  +                                       |   8        |
      Degeneration, Cystic                 |                      1                                                   |      1  1.0|
      Hypertrophy                          |                      3  2     1                                          |      3  2.0|
      Vacuolization Cytoplasmic            |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |             +  +  +  +  +  +  +  +                                       |   8        |
      Follicular Cell, Hypertrophy         |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                      |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                      |            |
                                           | 9| 9| 9| 9| 8| 8| 8| 8| 8| 8| 8| 8|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    3 NG/KG                                | 1| 3| 3| 6| 8| 8| 8| 9| 9| 9| 9| 9|                                      |      L     |
                                           | 9| 2| 5| 7| 7| 8| 9| 1| 2| 3| 4| 5|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Atrophy                              |                2        2                                                |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                +     +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |             +  +  +  +  +  +  +  +                                       |   8        |
      Infiltration Cellular, Histiocyte    |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  |                         +     +                                          |   2        |
      Cyst                                 |                         2                                                |      1  2.0|
      Inflammation, Chronic Active         |                               2                                          |      1  2.0|
      Pelvis, Dilatation                   |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                               +                                          |   1        |
      Transitional Epithelium, Hyperplasia |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         |                               +                                          |   1        |
      Inflammation                         |                               2                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                               2                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 8| 8| 8| 8| 8| 9| 9| 8| 8| 8| 9| 9| 9|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    10 NG/KG                               | 0| 0| 0| 0| 1| 1| 5| 5| 5| 5| 6| 7| 8|                                   |      L     |
                                           | 6| 7| 8| 9| 0| 4| 0| 3| 4| 5| 7| 1| 3|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +        +  +  +                                             |   8        |
      Basophilic Focus                     |          X                                                               |      1     |
      Inflammation                         | 1  1  1  1  1        1  1  1                                             |      8  1.0|
      Pigmentation                         | 1     1     1           1  1                                             |      5  1.0|
      Toxic Hepatopathy                    |                         1                                                |      1  1.0|
      Bile Duct, Cyst                      |                            2                                             |      1  2.0|
      Bile Duct, Hyperplasia               |                         1                                                |      1  1.0|
      Hepatocyte, Hypertrophy              | 1  1  1  1           1  1  2                                             |      7  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +        +  +  +                                             |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +        +  +  +                                             |   8        |
      Degeneration, Cystic                 | 2                                                                        |      1  2.0|
      Hypertrophy                          | 2  1                    1  1                                             |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |                      +                                                   |   1        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |                      +                                                   |   1        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +        +  +  +                                             |   8        |
      Follicular Cell, Hypertrophy         |    1     1                                                               |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 8| 8| 8| 8| 8| 9| 9| 8| 8| 8| 9| 9| 9|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    10 NG/KG                               | 0| 0| 0| 0| 1| 1| 5| 5| 5| 5| 6| 7| 8|                                   |      L     |
                                           | 6| 7| 8| 9| 0| 4| 0| 3| 4| 5| 7| 1| 3|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +        M  +  +                                             |   7        |
      Atrophy                              |       2  2                 3                                             |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |    +     +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +        +  +  +                                             |   8        |
      Infiltration Cellular, Histiocyte    |       1                    1                                             |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 9| 9| 9| 9| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |      A     |
    22 NG/KG                               | 1| 2| 2| 4| 5| 5| 5| 5| 5| 6| 6| 7| 9|                                   |      L     |
                                           | 5| 7| 8| 4| 1| 2| 3| 4| 5| 7| 8| 0| 3|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +  +  +  +  +  +  +  +                                       |   8        |
      Hepatodiaphragmatic Nodule           |             X                                                            |      1     |
      Inflammation                         |             1  1  1  2  2  2  1  2                                       |      8  1.5|
      Mixed Cell Focus                     |                X        X                                                |      2     |
      Mixed Cell Focus, Multiple           |                   X        X  X  X                                       |      4     |
      Pigmentation                         |             1  1  1  1  1  1  1  1                                       |      8  1.0|
      Bile Duct, Hyperplasia               |                         1     1                                          |      2  1.0|
      Hepatocyte, Hypertrophy              |             1  1  2  1  2  1  1  1                                       |      8  1.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |             +  +  +  +  +  +  +  +                                       |   8        |
      Degeneration, Cystic                 |                2     2                                                   |      2  2.0|
      Hypertrophy                          |                1  2  2        1                                          |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |             +  +  +  +  +  +  +  +                                       |   8        |
      Follicular Cell, Hypertrophy         |             2     1                                                      |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  |                         +                                                |   1        |
      Endometrium, Hyperplasia, Cystic     |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 9| 9| 9| 9| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |      A     |
    22 NG/KG                               | 1| 2| 2| 4| 5| 5| 5| 5| 5| 6| 6| 7| 9|                                   |      L     |
                                           | 5| 7| 8| 4| 1| 2| 3| 4| 5| 7| 8| 0| 3|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  |             +  +  +  +  +  +  +  +                                       |   8        |
      Atrophy                              |             2  3  2  2  2  3     2                                       |      7  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |             +  +  +  +  +  +  +  +                                       |   8        |
      Infiltration Cellular, Histiocyte    |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 9| 9| 9| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    46 NG/KG                               | 0| 0| 1| 4| 4| 4| 5| 5| 5| 5| 6| 7| 8|                                   |      L     |
                                           | 3| 8| 1| 1| 2| 4| 6| 7| 8| 9| 0| 6| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |          +  +  +  +  +  +  +  +                                          |   8        |
      Cholangiofibrosis                    |             3                                                            |      1  3.0|
      Fatty Change, Diffuse                |                   1  1                                                   |      2  1.0|
      Inflammation                         |          1  2  2  2  1  1  1  2                                          |      8  1.5|
      Mixed Cell Focus                     |                            X                                             |      1     |
      Mixed Cell Focus, Multiple           |          X  X  X  X  X  X                                                |      6     |
      Pigmentation                         |          1  2  2  2  2  2  2  1                                          |      8  1.8|
      Toxic Hepatopathy                    |          2  3  1  1  1     1                                             |      6  1.5|
      Bile Duct, Fibrosis                  |                   1                                                      |      1  1.0|
      Bile Duct, Hyperplasia               |          1  1     2                                                      |      3  1.3|
      Hepatocyte, Hypertrophy              |          2  2  2  1  2  1  4  2                                          |      8  2.0|
      Hepatocyte, Multinucleated           |                   1  1                                                   |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |          +  +  +  +  +  +  +  +                                          |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |          +  +  +  +  +  +  +  +                                          |   8        |
      Hyperplasia                          |             2     1           2                                          |      3  1.7|
      Hypertrophy                          |             1  1     1     1  1                                          |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +  +  +  +  +  +  +                                          |   8        |
      Follicular Cell, Hypertrophy         |             1        1     1                                             |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 9| 9| 9| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    46 NG/KG                               | 0| 0| 1| 4| 4| 4| 5| 5| 5| 5| 6| 7| 8|                                   |      L     |
                                           | 3| 8| 1| 1| 2| 4| 6| 7| 8| 9| 0| 6| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |          +  +  +  +  +  +  +  +                                          |   8        |
      Atrophy                              |          3  4  3  3  3  4  3  4                                          |      8  3.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |          +  +  +  +  +  +  +  +                                          |   8        |
      Infiltration Cellular, Histiocyte    |                2     1  1     1                                          |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 8| 8| 8|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                                   |      A     |
    100                                    | 0| 0| 0| 0| 0| 2| 9| 1| 2| 4| 4| 4| 4|                                   |      L     |
    NG/KG                                  | 1| 2| 3| 4| 5| 3| 0| 1| 0| 3| 6| 7| 8|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                 +  +  +                                    |   8        |
      Basophilic Focus                     |                               X     X                                    |      2     |
      Basophilic Focus, Multiple           |    X                                                                     |      1     |
      Cholangiofibrosis                    | 2                                                                        |      1  2.0|
      Fatty Change, Diffuse                | 3  1        1                 2  2  1                                    |      6  1.7|
      Inflammation                         | 2  2  2  2  2                 2  2  2                                    |      8  2.0|
      Mixed Cell Focus, Multiple           | X  X  X  X  X                 X  X  X                                    |      8     |
      Pigmentation                         | 3  3  3  2  2                 3  3  2                                    |      8  2.6|
      Toxic Hepatopathy                    | 3  4  3  3  3                 4  4  3                                    |      8  3.4|
      Bile Duct, Fibrosis                  | 2  2                                                                     |      2  2.0|
      Bile Duct, Hyperplasia               | 2  3  1  2  2                 2  2  1                                    |      8  1.9|
      Hepatocyte, Hypertrophy              | 4  4  3  2  3                 4  3  3                                    |      8  3.3|
      Hepatocyte, Multinucleated           | 2  2  2  1  2                 1  1  2                                    |      8  1.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                 +  +  +                                    |   8        |
      Inflammation, Chronic Active         |             2                 2                                          |      2  2.0|
      Acinus, Atrophy                      |             2                 2                                          |      2  2.0|
      Acinus, Vacuolization Cytoplasmic    | 1  1  1  1                    1  1  1                                    |      7  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                 +  +  +                                    |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                 +  +  +                                    |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                 +  +  +                                    |   8        |
      Degeneration, Cystic                 |       1                                                                  |      1  1.0|
      Hyperplasia                          | 1           2                                                            |      2  1.5|
      Hypertrophy                          |    1  2  3  1                 2  2  3                                    |      7  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 8| 8| 8|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                                   |      A     |
    100                                    | 0| 0| 0| 0| 0| 2| 9| 1| 2| 4| 4| 4| 4|                                   |      L     |
    NG/KG                                  | 1| 2| 3| 4| 5| 3| 0| 1| 0| 3| 6| 7| 8|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +                 +  +  +                                    |   8        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                 +  +  +                                    |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +                 +  +  +                                    |   7        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                 +  +  +                                    |   8        |
      Follicular Cell, Hypertrophy         |    1     1                    4  1  1                                    |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M  +                 +  +  +                                    |   7        |
      Atrophy                              | 4  4  4                          4  4                                    |      5  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                 +  +  +                                    |   8        |
      Metaplasia, Squamous                 |    2  1  1                          2                                    |      4  1.5|
      Endometrium, Hyperplasia, Cystic     |          4                          1                                    |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +                 +  +  +                                    |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                 +  +  +                                    |   8        |
      Pigmentation                         | 1  2  2  2  1                 2  2  2                                    |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                 +  +  +                                    |   8        |
      Atrophy                              | 3  4  2  3  4                 3  4  4                                    |      8  3.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                 +  +  +                                    |   8        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02    
Route: GAVAGE                                                                                                     Time: 12:14:12    
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                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 8| 8| 8|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                                   |      A     |
    100                                    | 0| 0| 0| 0| 0| 2| 9| 1| 2| 4| 4| 4| 4|                                   |      L     |
    NG/KG                                  | 1| 2| 3| 4| 5| 3| 0| 1| 0| 3| 6| 7| 8|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                 +  +  +                                    |   8        |
      Infiltration Cellular, Histiocyte    |    1                          1     1                                    |      3  1.0|
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 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
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 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  |          +                                                               |   1        |
      Nephropathy                          |          3                                                               |      1  3.0|
      Pelvis, Dilatation                   |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |          +                                                               |   1        |
      Mineralization                       |          3                                                               |      1  3.0|
      Transitional Epithelium, Hyperplasia |          2                                                               |      1  2.0|
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  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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