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TDMS Study 96007-03 Pathology Tables

NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:18:35

                                                          53 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1746-01-6

       Lock Date:  06/28/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     06/03/99 - 06/04/99

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    3 NG/KG
                               Include 003    10 NG/KG
                               Include 004    22 NG/KG
                               Include 005    46 NG/KG
                               Include 006    100     NG/KG




























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02    
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:18:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100          
                                                                                                                       NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98           98           98           98           98           
                                                                                                                                    
  Scheduled Sacrifice                                 13           12           13           13           13           13           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8            8            8            8            8            8           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (8)          (8)          (8)          (8)          (8)          
      Basophilic Focus                                                           1                                      2           
      Basophilic Focus, Multiple                                    1                                                   1           
      Cholangiofibrosis                                                                                    1 [3.0]      1 [2.0]     
      Clear Cell Focus                                 2                                                                            
      Fatty Change, Diffuse                                                                                2 [1.0]      6 [1.7]     
      Hepatodiaphragmatic Nodule                                                              1                                     
      Inflammation                                     8 [1.0]      8 [1.0]      8 [1.0]      8 [1.5]      8 [1.5]      8 [2.0]     
      Mixed Cell Focus                                 2            1                         2            1                        
      Mixed Cell Focus, Multiple                                    4                         4            6            8           
      Pigmentation                                                               5 [1.0]      8 [1.0]      8 [1.8]      8 [2.6]     
      Toxic Hepatopathy                                                          1 [1.0]                   6 [1.5]      8 [3.4]     
      Bile Duct, Cyst                                                            1 [2.0]                                            
      Bile Duct, Fibrosis                                                                                  1 [1.0]      2 [2.0]     
      Bile Duct, Hyperplasia                                                     1 [1.0]      2 [1.0]      3 [1.3]      8 [1.9]     
      Hepatocyte, Hypertrophy                                       4 [1.0]      7 [1.1]      8 [1.3]      8 [2.0]      8 [3.3]     
      Hepatocyte, Multinucleated                                                                           2 [1.0]      8 [1.6]     
   Pancreas                                           (8)          (8)          (8)          (8)          (8)          (8)          
      Inflammation, Chronic Active                                                                                      2 [2.0]     
      Acinus, Atrophy                                                                                                   2 [2.0]     
      Acinus, Vacuolization Cytoplasmic                                                                                 7 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (8)          (8)          (8)          (8)          (8)          (8)          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02    
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:18:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100          
                                                                                                                       NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Degeneration, Cystic                             1 [1.0]      1 [1.0]      1 [2.0]      2 [2.0]                   1 [1.0]     
      Hyperplasia                                      1 [1.0]                                             3 [1.7]      2 [1.5]     
      Hypertrophy                                      5 [1.6]      3 [2.0]      4 [1.3]      4 [1.5]      5 [1.0]      7 [2.0]     
      Vacuolization Cytoplasmic                                     1 [1.0]                                                         
   Pituitary Gland                                    (8)                       (1)                                    (7)          
      Cyst                                             1 [3.0]                                                                      
   Thyroid Gland                                      (8)          (8)          (8)          (8)          (8)          (8)          
      Follicular Cell, Hypertrophy                                  1 [1.0]      2 [1.0]      2 [1.5]      3 [1.0]      5 [1.6]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)                                                              (7)          
      Atrophy                                          8 [4.0]                                                          5 [4.0]     
   Uterus                                             (8)                                    (1)                       (8)          
      Metaplasia, Squamous                             7 [2.4]                                                          4 [1.5]     
      Cervix, Cyst, Squamous                           1 [3.0]                                                                      
      Endometrium, Hyperplasia, Cystic                 5 [2.0]                                1 [4.0]                   2 [2.5]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (8)                                                              (8)          
      Hyperplasia, Focal, Lymphoid                     1 [2.0]                                                                      
      Pigmentation                                     8 [1.8]                                                          8 [1.8]     
   Thymus                                             (8)          (8)          (7)          (8)          (8)          (8)          
      Atrophy                                          4 [2.0]      2 [2.0]      3 [2.3]      7 [2.3]      8 [3.4]      8 [3.4]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (8)          (2)          (2)                                    (8)          
      Cyst                                             3 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02    
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:18:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100          
                                                                                                                       NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (8)          (8)          (8)          (8)          (8)          
      Infiltration Cellular, Histiocyte                3 [1.0]      1 [1.0]      2 [1.0]      1 [1.0]      4 [1.3]      3 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                                          (2)                                                 (1)          
      Cyst                                                          1 [2.0]                                                         
      Inflammation, Chronic Active                                  1 [2.0]                                                         
      Nephropathy                                                                                                       1 [3.0]     
      Pelvis, Dilatation                                            1 [3.0]                                             1 [2.0]     
   Ureter                                                          (1)                                                 (1)          
      Mineralization                                                                                                    1 [3.0]     
      Transitional Epithelium, Hyperplasia                          1 [3.0]                                             1 [2.0]     
   Urinary Bladder                                                 (1)                                                              
      Inflammation                                                  1 [2.0]                                                         
      Transitional Epithelium, Hyperplasia                          1 [2.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
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