National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5318

TDMS Study 96007-03 Pathology Tables

NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03
Route: GAVAGE                                                                                                     Time: 08:37:13

                                                         FINAL # 3 RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1746-01-6

       Lock Date:  06/28/01

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          98           98           98           98           98           98           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19           27           15           19           17           17           
    Natural Death                                      9            6           10           15           14           15           
    Dosing Accident                                                              5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           21           23           19           22           21           
                                                                                                                                    
  Animals Examined Microscopically                    53           54           53           53           53           53           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (52)         (54)         (53)         (52)         (53)         (53)         
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Jejunum                           (51)         (54)         (53)         (53)         (53)         (52)         
      Leiomyoma                                                                                            1 (2%)                   
   Liver                                              (53)         (54)         (53)         (53)         (53)         (53)         
      Carcinoma, Metastatic, Pancreas                                                                                   2 (4%)      
      Carcinoma, Metastatic, Uterus                                                                        2 (4%)                   
      Cholangiocarcinoma                                                                      1 (2%)       3 (6%)       8 (15%)     
      Cholangiocarcinoma, Multiple                                                                         1 (2%)      17 (32%)     
      Hepatocellular Adenoma                                                                               1 (2%)      10 (19%)     
      Hepatocellular Adenoma, Multiple                                                                                  3 (6%)      
      Hepatocholangioma                                                                                                 2 (4%)      
   Mesentery                                          (2)          (2)                       (1)          (6)          (8)          
      Carcinoma, Metastatic, Uterus                                                                        1 (17%)                  
      Schwannoma Malignant                             1 (50%)                                                                      
   Oral Mucosa                                        (2)          (9)          (16)         (16)         (22)         (29)         
      Gingival, Squamous Cell Carcinoma                1 (50%)      2 (22%)      1 (6%)                    4 (18%)     10 (34%)     
   Pancreas                                           (51)         (54)         (52)         (53)         (52)         (51)         
      Carcinoma, Metastatic, Uterus                                                                        1 (2%)                   
      Acinus, Adenoma                                                                                                   1 (2%)      
      Acinus, Carcinoma                                                                                                 2 (4%)      
   Stomach, Forestomach                               (53)         (54)         (53)         (53)         (53)         (53)         
      Squamous Cell Carcinoma                          1 (2%)                                              1 (2%)                   
      Squamous Cell Papilloma                                                                              1 (2%)       1 (2%)      
   Stomach, Glandular                                 (53)         (54)         (53)         (53)         (53)         (53)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (53)         (54)         (53)         (52)         (53)         (52)         
      Schwannoma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (53)         (54)         (53)         (53)         (53)         (53)         
      Adenoma                                          1 (2%)                    2 (4%)       2 (4%)       1 (2%)       1 (2%)      
      Carcinoma                                                                               1 (2%)                                
      Pheochromocytoma Benign                                                                                           1 (2%)      
      Capsule, Sarcoma, Metastatic, Skeletal Muscle                              1 (2%)                                             
   Adrenal Medulla                                    (53)         (54)         (53)         (53)         (53)         (53)         
      Pheochromocytoma Malignant                                                                                        1 (2%)      
      Pheochromocytoma Benign                          3 (6%)       2 (4%)       2 (4%)       3 (6%)       3 (6%)       3 (6%)      
   Islets, Pancreatic                                 (51)         (54)         (53)         (53)         (52)         (52)         
      Adenoma                                          1 (2%)                    2 (4%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (46)         (47)         (47)         (44)         (45)         (45)         
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (53)         (54)         (52)         (53)         (53)         (52)         
      Adenoma                                          4 (8%)                                                           1 (2%)      
      Meningioma Malignant, Metastatic, Brain                                                 1 (2%)                                
      Pars Distalis, Adenoma                          18 (34%)     20 (37%)     26 (50%)     15 (28%)     20 (38%)     10 (19%)     
      Pars Distalis, Adenoma, Multiple                 3 (6%)                                                                       
      Pars Intermedia, Adenoma                         2 (4%)                                                                       
   Thyroid Gland                                      (52)         (54)         (53)         (51)         (53)         (52)         
      Bilateral, C-Cell, Adenoma                       3 (6%)       3 (6%)       2 (4%)       2 (4%)       1 (2%)       3 (6%)      
      C-Cell, Adenoma                                 17 (33%)     12 (22%)     15 (28%)     14 (27%)     12 (23%)      8 (15%)     
      C-Cell, Carcinoma                                1 (2%)       1 (2%)                                 2 (4%)                   
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                                                                           1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (52)         (53)         (52)         (51)         (53)         
   Ovary                                              (51)         (53)         (53)         (53)         (53)         (53)         
      Granulosa Cell Tumor Malignant                                                                       1 (2%)                   
      Thecoma Benign                                                                                       1 (2%)                   
      Periovarian Tissue, Schwannoma Malignant,                                                                                     
           Metastatic, Uterus                          1 (2%)                                                                       
   Uterus                                             (52)         (53)         (53)         (53)         (53)         (53)         
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                                     1 (2%)                                 2 (4%)       1 (2%)      
      Carcinoma, Multiple                                                                     1 (2%)                                
      Hemangiosarcoma                                                                                      1 (2%)                   
      Leiomyoma                                        1 (2%)                                                                       
      Polyp Stromal                                    9 (17%)      7 (13%)      4 (8%)       8 (15%)      9 (17%)      7 (13%)     
      Polyp Stromal, Multiple                          2 (4%)                                 3 (6%)       1 (2%)       1 (2%)      
      Squamous Cell Carcinoma                                                                              4 (8%)                   
      Squamous Cell Carcinoma, Multiple                                                                    1 (2%)                   
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
      Cervix, Carcinoma                                             1 (2%)                                                          
      Cervix, Schwannoma Malignant                     1 (2%)                                                                       
   Vagina                                                          (1)          (1)          (3)          (3)          (1)          
      Schwannoma Malignant                                                                                 1 (33%)      1 (100%)    
      Schwannoma Malignant, Metastatic, Skin                                                  1 (33%)                               
      Squamous Cell Carcinoma                                                                              1 (33%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (54)         (53)         (53)         (53)         (53)         
   Lymph Node                                         (2)          (6)          (3)          (5)          (6)          (9)          
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (50%)                                                                      
      Lumbar, Carcinoma, Metastatic, Uterus                                                                1 (17%)                  
   Lymph Node, Mandibular                             (51)         (54)         (52)         (50)         (51)         (52)         
   Lymph Node, Mesenteric                             (52)         (53)         (53)         (53)         (53)         (51)         
   Spleen                                             (51)         (54)         (53)         (53)         (52)         (52)         
      Hemangiosarcoma                                                                                      1 (2%)                   
      Schwannoma Malignant, Metastatic, Uterus         1 (2%)                                                                       
   Thymus                                             (51)         (52)         (52)         (49)         (46)         (42)         
      Carcinoma, Metastatic, Lung                                   1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Lung                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (54)         (53)         (53)         (53)         (53)         
      Adenoma                                          2 (4%)                    1 (2%)                                 1 (2%)      
      Carcinoma                                        3 (6%)       7 (13%)      4 (8%)       2 (4%)       2 (4%)                   
      Carcinoma, Multiple                              1 (2%)       1 (2%)                                                          
      Fibroadenoma                                    21 (40%)     26 (48%)     17 (32%)     17 (32%)     24 (45%)     20 (38%)     
      Fibroadenoma, Multiple                          12 (23%)     14 (26%)     17 (32%)     12 (23%)     12 (23%)      4 (8%)      
   Skin                                               (53)         (54)         (53)         (53)         (53)         (53)         
      Basal Cell Carcinoma                             1 (2%)                    1 (2%)                                             
      Fibroma                                          1 (2%)                    2 (4%)                                 1 (2%)      
      Fibrosarcoma                                                                            1 (2%)                                
      Keratoacanthoma                                                                         1 (2%)                                
      Lipoma                                                        1 (2%)                                                          
      Myxosarcoma                                                                1 (2%)                                             
      Schwannoma Malignant                             1 (2%)                                 2 (4%)                    1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (53)         (54)         (53)         (53)         (53)         (53)         
      Cranium, Schwannoma Malignant, Metastatic,                                                                                    
           Skin                                                                               1 (2%)                                
      Periosteum, Fibrosarcoma                                                                1 (2%)                                
   Skeletal Muscle                                                              (1)          (2)                                    
      Fibrous Histiocytoma                                                                    1 (50%)                               
      Sarcoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (54)         (53)         (53)         (53)         (53)         
      Glioma Malignant                                                           1 (2%)                                             
      Granular Cell Tumor Malignant                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (54)         (53)         (52)         (53)         (52)         
      Alveolar/Bronchiolar Adenoma, Multiple                                                               1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Pancreas                                                                                   1 (2%)      
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Cystic Keratinizing Epithelioma                                                                                   7 (13%)     
      Cystic Keratinizing Epithelioma, Multiple                                                                         2 (4%)      
      Nephroblastoma, Metastatic, Kidney                            1 (2%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
      Mediastinum, Sarcoma                                                       1 (2%)                                 1 (2%)      
   Nose                                               (53)         (54)         (53)         (53)         (53)         (53)         
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                                                        1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                       (2)                                    (1)          
      Pinna, Neural Crest Tumor                        1 (50%)                                                                      
   Harderian Gland                                    (53)         (54)         (53)         (52)         (53)         (53)         
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                                                        3 (6%)      
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (54)         (53)         (53)         (53)         (53)         
      Nephroblastoma                                                2 (4%)       1 (2%)                                             
      Schwannoma Malignant, Metastatic, Uterus         1 (2%)                                                                       
      Stromal Nephroma                                                                        1 (2%)                                
   Urinary Bladder                                    (52)         (53)         (53)         (52)         (53)         (53)         
      Polyp                                                         1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Uterus         1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Uterus                                                          1 (2%)                   
      Transitional Epithelium, Carcinoma                                                                   1 (2%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(53)        *(54)        *(53)        *(53)        *(53)        *(53)         
      Leukemia Granulocytic                                                      1 (2%)                                             
      Lymphoma Malignant                                            1 (2%)       1 (2%)                    1 (2%)       2 (4%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          54          48          44          50          50               
     Total Primary Neoplasms                          116         105         106          89         116         131               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45          49          45          40          46          42               
     Total Benign Neoplasms                           102          86          92          78          88          87               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              13          19          13          11          24          34               
     Total Malignant Neoplasms                         13          19          14          11          28          44               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3           2           2           3           6               
     Total Metastatic Neoplasm                          6           3           3           3           6           7               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                100 NG/                                                                          
                                                   KG/STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50                                                                            
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16                                                                            
    Natural Death                                     13                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                21                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50                                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (50)                                                                          
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)                                                                          
      Schwannoma Malignant, Metastatic, Heart          1 (2%)                                                                       
   Liver                                              (50)                                                                          
      Cholangiocarcinoma                               1 (2%)                                                                       
      Cholangiocarcinoma, Multiple                     1 (2%)                                                                       
      Cholangioma                                      1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Hepatocellular Adenoma                           2 (4%)                                                                       
      Schwannoma Malignant, Metastatic, Heart          1 (2%)                                                                       
   Oral Mucosa                                        (11)                                                                          
      Gingival, Squamous Cell Carcinoma                5 (45%)                                                                      
   Pancreas                                           (49)                                                                          
      Acinus, Carcinoma                                1 (2%)                                                                       
   Tongue                                             (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)                                                                          
      Aorta, Fibrous Histiocytoma, Metastatic, Skin    1 (2%)                                                                       
   Heart                                              (50)                                                                          
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Schwannoma Malignant                             3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                100 NG/                                                                          
                                                   KG/STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)                                                                          
      Capsule, Schwannoma Malignant, Metastatic,                                                                                    
           Heart                                       1 (2%)                                                                       
   Adrenal Medulla                                    (50)                                                                          
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Pituitary Gland                                    (50)                                                                          
      Pars Distalis, Adenoma                          19 (38%)                                                                      
   Thyroid Gland                                      (49)                                                                          
      Bilateral, C-Cell, Adenoma                       2 (4%)                                                                       
      C-Cell, Adenoma                                 11 (22%)                                                                      
      C-Cell, Carcinoma                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)                                                                          
      Carcinoma, Metastatic, Uterus                    1 (2%)                                                                       
   Uterus                                             (50)                                                                          
      Carcinoma                                        2 (4%)                                                                       
      Polyp Stromal                                    3 (6%)                                                                       
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Squamous Cell Carcinoma                          2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)                                                                          
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
   Lymph Node, Mesenteric                             (49)                                                                          
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
   Spleen                                             (49)                                                                          
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Heart          1 (2%)                                                                       
   Thymus                                             (49)                                                                          
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                100 NG/                                                                          
                                                   KG/STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)                                                                          
      Adenolipoma                                      1 (2%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
      Fibroadenoma                                    19 (38%)                                                                      
      Fibroadenoma, Multiple                          13 (26%)                                                                      
   Skin                                               (50)                                                                          
      Fibroma                                          1 (2%)                                                                       
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Liposarcoma                                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                                                                          
      Squamous Cell Carcinoma, Metastatic, Tongue      1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                                                           
      Fibrous Histiocytoma, Metastatic, Skin           1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                                                                          
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Heart          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                100 NG/                                                                          
                                                   KG/STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)                                                                          
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)                                                                          
      Adenolipoma                                      1 (2%)                                                                       
      Lymphoma Malignant                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03  
Route: GAVAGE                                                                                                     Time: 08:37:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                100 NG/                                                                          
                                                   KG/STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46                                                                           
     Total Primary Neoplasms                           98                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41                                                                           
     Total Benign Neoplasms                            74                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19                                                                           
     Total Malignant Neoplasms                         24                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5                                                                           
     Total Metastatic Neoplasm                         19                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.