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TDMS Study 96007-04 Pathology Tables

NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03
Route: GAVAGE                                                                                                     Time: 10:29:25

                                                      31 WEEK SSAC/FINAL#1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFDIOXINMIX

       Lock Date:  09/12/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     01/13/99 - 01/14/99

       Treatment Groups:       Include 001    TERT.MIXCONTROL
                               Include 002    TERT.MIXTEQ=10
                               Include 003    TERT.MIXTEQ=22
                               Include 004    TERT.MIXTEQ=46
                               Include 005    TERT.MIXTEQ=100






























a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:29:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                     
                                                   CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98           98           98           98                        
                                                                                                                                    
  Scheduled Sacrifice                                 16           16           16           16           16                        
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)                      
      Clear Cell Focus                                                           1 (10%)                                            
      Eosinophilic Focus                                                                                   1 (10%)                  
      Fatty Change, Diffuse                                                                                1 (10%)                  
      Inflammation                                     8 (80%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)                 
      Mixed Cell Focus                                 3 (30%)      2 (20%)      1 (10%)      4 (40%)      2 (20%)                  
      Mixed Cell Focus, Multiple                       3 (30%)      2 (20%)      4 (40%)      4 (40%)      6 (60%)                  
      Pigmentation                                                  4 (40%)      9 (90%)     10 (100%)    10 (100%)                 
      Hepatocyte, Hypertrophy                                       3 (30%)      5 (50%)      9 (90%)     10 (100%)                 
      Hepatocyte, Multinucleated                                                              1 (10%)      8 (80%)                  
   Pancreas                                           (10)         (10)         (10)         (10)         (10)                      
      Inflammation, Chronic Active                     1 (10%)                                             1 (10%)                  
      Acinus, Atrophy                                  1 (10%)      1 (10%)      2 (20%)                                            
      Acinus, Vacuolization Cytoplasmic                                                                    5 (50%)                  
   Stomach, Glandular                                 (10)                                                (10)                      
      Glands, Ectasia                                                                                      2 (20%)                  
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 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)         (10)                      
      Degeneration, Cystic                             1 (10%)                                                                      
      Hyperplasia                                      1 (10%)                                             2 (20%)                  
      Hypertrophy                                      5 (50%)      1 (10%)      1 (10%)      1 (10%)      3 (30%)                  
      Vacuolization Cytoplasmic                        1 (10%)                                                                      
   Pituitary Gland                                    (10)                                                (10)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
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NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:29:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                     
                                                   CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (10%)                                                                      
      Hypertrophy                                                                                          1 (10%)                  
   Thyroid Gland                                      (10)         (10)         (10)         (10)         (10)                      
      C-Cell, Hyperplasia                              1 (10%)                                                                      
      Follicular Cell, Hypertrophy                     1 (10%)      5 (50%)      1 (10%)      4 (40%)      3 (30%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)         (10)                      
      Atrophy                                         10 (100%)     9 (90%)      9 (90%)      8 (80%)      9 (90%)                  
   Uterus                                             (10)         (10)         (10)         (10)         (10)                      
      Inflammation, Suppurative                        4 (40%)                   1 (10%)                   2 (20%)                  
      Metaplasia, Squamous                             8 (80%)      9 (90%)      8 (80%)      8 (80%)      8 (80%)                  
      Endometrium, Hyperplasia, Cystic                 2 (20%)                   1 (10%)                   2 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                   (1)                                                 
      Metaplasia, Squamous                                                       1 (100%)                                           
   Spleen                                             (10)                                                (10)                      
      Pigmentation                                    10 (100%)                                           10 (100%)                 
   Thymus                                             (10)         (10)         (10)         (10)         (9)                       
      Atrophy                                                                    3 (30%)      7 (70%)      7 (78%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:29:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                     
                                                   CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)         (10)                      
      Hemorrhage                                                                              1 (10%)                               
      Infiltration Cellular, Histiocyte                1 (10%)      1 (10%)      1 (10%)                   1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                                                                    (1)                                    
      Inflammation, Chronic Active                                                            1 (100%)                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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