National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5903

TDMS Study 96007-04 Pathology Tables

NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03
Route: GAVAGE                                                                                                     Time: 10:35:31

                                                      31 WEEK SSAC/FINAL#1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFDIOXINMIX

       Lock Date:  09/12/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     01/13/99 - 01/14/99

       Treatment Groups:       Include 001    TERT.MIXCONTROL
                               Include 002    TERT.MIXTEQ=10
                               Include 003    TERT.MIXTEQ=22
                               Include 004    TERT.MIXTEQ=46
                               Include 005    TERT.MIXTEQ=100
































                                                              Page   1


NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 3| 3| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    TERT.MIX                               | 1| 2| 4| 4| 4| 4| 4| 4| 5| 6| 8| 8| 8| 8| 9| 9|                          |      L     |
    CONTROL                                | 1| 2| 1| 2| 3| 4| 5| 7| 4| 8| 6| 7| 8| 9| 0| 7|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Inflammation                         |          1     1  1           1  1  1  1  1                              |      8  1.0|
      Mixed Cell Focus                     |             X                    X  X                                    |      3     |
      Mixed Cell Focus, Multiple           |                X  X           X                                          |      3     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Inflammation, Chronic Active         |                                        1                                 |      1  1.0|
      Acinus, Atrophy                      |                                        1                                 |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +  +  +           +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +  +  +           +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Degeneration, Cystic                 |                   2                                                      |      1  2.0|
      Hyperplasia                          |                                  2                                       |      1  2.0|
      Hypertrophy                          |          2  1  1  2                    1                                 |      5  1.4|
      Vacuolization Cytoplasmic            |                                        1                                 |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |       +  +  +  +  +           +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +  +  +           +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      C-Cell, Hyperplasia                  |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 3| 3| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    TERT.MIX                               | 1| 2| 4| 4| 4| 4| 4| 4| 5| 6| 8| 8| 8| 8| 9| 9|                          |      L     |
    CONTROL                                | 1| 2| 1| 2| 3| 4| 5| 7| 4| 8| 6| 7| 8| 9| 0| 7|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Follicular Cell, Hypertrophy         |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Atrophy                              |       4  4  4  4  2           4  4  4  4  4                              |     10  3.8|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Inflammation, Suppurative            |       1  1                       1        2                              |      4  1.3|
      Metaplasia, Squamous                 |       1  2  1  2              2  2  2     3                              |      8  1.9|
      Endometrium, Hyperplasia, Cystic     |                               3           4                              |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |       +  +  +  +  +           +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Pigmentation                         |       1  1  1  1  1           2  2  1  2  2                              |     10  1.4|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +  +           +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |       +  +  +  +  +           +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 3| 3| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    TERT.MIX                               | 1| 2| 4| 4| 4| 4| 4| 4| 5| 6| 8| 8| 8| 8| 9| 9|                          |      L     |
    CONTROL                                | 1| 2| 1| 2| 3| 4| 5| 7| 4| 8| 6| 7| 8| 9| 0| 7|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +  +           +  +  +  +  +                              |  10        |
      Infiltration Cellular, Histiocyte    |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |      A     |
    TERT.MIX                               | 0| 1| 3| 4| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9|                          |      L     |
    TEQ=10                                 | 6| 6| 7| 4| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +  +  +  +  +  +  +                              |  10        |
      Inflammation                         |                1  1  1  1  1  1  1  1  1  1                              |     10  1.0|
      Mixed Cell Focus                     |                            X     X                                       |      2     |
      Mixed Cell Focus, Multiple           |                         X           X                                    |      2     |
      Pigmentation                         |                1        1  1              1                              |      4  1.0|
      Hepatocyte, Hypertrophy              |                      1  1              1                                 |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +  +  +  +  +  +  +                              |  10        |
      Acinus, Atrophy                      |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |                +  +  +  +  +  +  +  +  +  +                              |  10        |
      Hypertrophy                          |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       |                +                                                         |   1        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +                              |  10        |
      Follicular Cell, Hypertrophy         |                   1  2  3     2  1                                       |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |                +  +  +  +  +  +  +  +  +  +                              |  10        |
      Atrophy                              |                4  4  3     4  4  3  4  4  4                              |      9  3.8|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |                +  +  +  +  +  +  +  +  +  +                              |  10        |
      Metaplasia, Squamous                 |                2  1  3     1  1  1  1  2  1                              |      9  1.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |      A     |
    TERT.MIX                               | 0| 1| 3| 4| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9|                          |      L     |
    TEQ=10                                 | 6| 6| 7| 4| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |                +  +  +  +  +  +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                   +  +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +  +  +  +  +  +  +                              |  10        |
      Infiltration Cellular, Histiocyte    |                                     1                                    |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 3| 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 3| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    TERT.MIX                               | 1| 3| 3| 3| 3| 3| 4| 4| 5| 7| 7| 7| 7| 7| 7| 8|                          |      L     |
    TEQ=22                                 | 3| 0| 6| 7| 8| 9| 0| 8| 1| 1| 2| 3| 4| 5| 9| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Clear Cell Focus                     |                                        X                                 |      1     |
      Inflammation                         |       1  1  1  1  2        1  1  1  1  1                                 |     10  1.1|
      Mixed Cell Focus                     |                                        X                                 |      1     |
      Mixed Cell Focus, Multiple           |          X  X                 X     X                                    |      4     |
      Pigmentation                         |       1  1  1     1        1  1  1  1  2                                 |      9  1.1|
      Hepatocyte, Hypertrophy              |       1     1  1  1        1                                             |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Acinus, Atrophy                      |                            1     1                                       |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Hypertrophy                          |                                  1                                       |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Follicular Cell, Hypertrophy         |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Atrophy                              |       4  4     4  4        4  4  4  4  4                                 |      9  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Inflammation, Suppurative            |                                  2                                       |      1  2.0|
      Metaplasia, Squamous                 |       2  2     3  2        1  2     2  1                                 |      8  1.9|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 3| 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 3| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    TERT.MIX                               | 1| 3| 3| 3| 3| 3| 4| 4| 5| 7| 7| 7| 7| 7| 7| 8|                          |      L     |
    TEQ=22                                 | 3| 0| 6| 7| 8| 9| 0| 8| 1| 1| 2| 3| 4| 5| 9| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Endometrium, Hyperplasia, Cystic     |                                  4                                       |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                        +                                 |   1        |
      Metaplasia, Squamous                 |                                        1                                 |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Atrophy                              |          2                          1  1                                 |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +  +        +  +  +  +  +                                 |  10        |
      Infiltration Cellular, Histiocyte    |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    TERT.MIX                               | 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 5| 5| 6| 6| 8| 8|                          |      L     |
    TEQ=46                                 | 1| 2| 3| 4| 5| 8| 6| 7| 8| 9| 0| 7| 3| 5| 0| 3|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Inflammation                         | 1  1  2  1  1     2  1  1  2  1                                          |     10  1.3|
      Mixed Cell Focus                     |    X                    X  X  X                                          |      4     |
      Mixed Cell Focus, Multiple           | X        X  X     X                                                      |      4     |
      Pigmentation                         | 2  1  2  1  2     1  1  2  2  2                                          |     10  1.6|
      Hepatocyte, Hypertrophy              | 2  1  1  2  1     1  2  1     1                                          |      9  1.3|
      Hepatocyte, Multinucleated           |    1                                                                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +  +                                          |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Hypertrophy                          |             1                                                            |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Follicular Cell, Hypertrophy         | 2  3                 2     1                                             |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Atrophy                              | 3  3     4  4     4  4     4  4                                          |      8  3.8|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Metaplasia, Squamous                 | 2  1     2  1     2  2     2  3                                          |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    TERT.MIX                               | 0| 0| 0| 0| 0| 0| 4| 4| 4| 4| 5| 5| 6| 6| 8| 8|                          |      L     |
    TEQ=46                                 | 1| 2| 3| 4| 5| 8| 6| 7| 8| 9| 0| 7| 3| 5| 0| 3|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Atrophy                              | 2     2  2  2        2  1     2                                          |      7  1.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Hemorrhage                           |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  |                            +                                             |   1        |
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    TERT.MIX                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 4| 5| 6| 7| 9|                          |      L     |
    TEQ=100                                | 1| 2| 3| 4| 5| 4| 6| 7| 8| 9| 0| 7| 6| 2| 1| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Eosinophilic Focus                   | X                                                                        |      1     |
      Fatty Change, Diffuse                |                   1                                                      |      1  1.0|
      Inflammation                         | 2  1  2  1  2     1  2  2  2  1                                          |     10  1.6|
      Mixed Cell Focus                     |                            X  X                                          |      2     |
      Mixed Cell Focus, Multiple           |       X  X  X     X  X  X                                                |      6     |
      Pigmentation                         | 2  1  2  2  2     1  2  1  2  1                                          |     10  1.6|
      Hepatocyte, Hypertrophy              | 1  2  2  1  2     2  1  1  1  1                                          |     10  1.4|
      Hepatocyte, Multinucleated           | 1  1  1     1     1  1  1  2                                             |      8  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Inflammation, Chronic Active         |       1                                                                  |      1  1.0|
      Acinus, Vacuolization Cytoplasmic    | 1  1     1              1  1                                             |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +                                          |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Glands, Ectasia                      | 2                       1                                                |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Hyperplasia                          |                   2     2                                                |      2  2.0|
      Hypertrophy                          | 1     1     1                                                            |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +     +  +  +  +  +                                          |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +                                          |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +                                          |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    TERT.MIX                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 4| 5| 6| 7| 9|                          |      L     |
    TEQ=100                                | 1| 2| 3| 4| 5| 4| 6| 7| 8| 9| 0| 7| 6| 2| 1| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hypertrophy                          |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Follicular Cell, Hypertrophy         | 1           1     1                                                      |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Atrophy                              | 4  4  4  4  4     4  4     3  4                                          |      9  3.9|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Inflammation, Suppurative            | 1        1                                                               |      2  1.0|
      Metaplasia, Squamous                 | 2     1  2  2     2  2     2  1                                          |      8  1.8|
      Endometrium, Hyperplasia, Cystic     |    4  4                                                                  |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +     +  +  +  +  +                                          |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Pigmentation                         | 1  1  2  2  2     2  1  1  1  1                                          |     10  1.4|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +     +  +  +  +  +                                          |   9        |
      Atrophy                              | 2           2     3  2  3  1  2                                          |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +  +  +  +  +                                          |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:35:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    TERT.MIX                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 4| 5| 6| 7| 9|                          |      L     |
    TEQ=100                                | 1| 2| 3| 4| 5| 4| 6| 7| 8| 9| 0| 7| 6| 2| 1| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Infiltration Cellular, Histiocyte    |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.