Share This:
https://ntp.niehs.nih.gov/go/5907

TDMS Study 96007-04 Pathology Tables

NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/22/03
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 10:36:36

                                                      31 WEEK SSAC/FINAL#1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFDIOXINMIX

       Lock Date:  09/12/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     01/13/99 - 01/14/99

       Treatment Groups:       Include 001    TERT.MIXCONTROL
                               Include 002    TERT.MIXTEQ=10
                               Include 003    TERT.MIXTEQ=22
                               Include 004    TERT.MIXTEQ=46
                               Include 005    TERT.MIXTEQ=100





























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/22/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 10:36:36    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98           98           98           98                        
                                                                                                                                    
  Scheduled Sacrifice                                 16           16           16           16           16                        
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)                      
      Clear Cell Focus                                                           1                                                  
      Eosinophilic Focus                                                                                   1                        
      Fatty Change, Diffuse                                                                                1 [1.0]                  
      Inflammation                                     8 [1.0]     10 [1.0]     10 [1.1]     10 [1.3]     10 [1.6]                  
      Mixed Cell Focus                                 3            2            1            4            2                        
      Mixed Cell Focus, Multiple                       3            2            4            4            6                        
      Pigmentation                                                  4 [1.0]      9 [1.1]     10 [1.6]     10 [1.6]                  
      Hepatocyte, Hypertrophy                                       3 [1.0]      5 [1.0]      9 [1.3]     10 [1.4]                  
      Hepatocyte, Multinucleated                                                              1 [1.0]      8 [1.1]                  
   Pancreas                                           (10)         (10)         (10)         (10)         (10)                      
      Inflammation, Chronic Active                     1 [1.0]                                             1 [1.0]                  
      Acinus, Atrophy                                  1 [1.0]      1 [1.0]      2 [1.0]                                            
      Acinus, Vacuolization Cytoplasmic                                                                    5 [1.0]                  
   Stomach, Glandular                                 (10)                                                (10)                      
      Glands, Ectasia                                                                                      2 [1.5]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)         (10)                      
      Degeneration, Cystic                             1 [2.0]                                                                      
      Hyperplasia                                      1 [2.0]                                             2 [2.0]                  
      Hypertrophy                                      5 [1.4]      1 [1.0]      1 [1.0]      1 [1.0]      3 [1.0]                  
      Vacuolization Cytoplasmic                        1 [1.0]                                                                      
   Pituitary Gland                                    (10)                                                (10)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/22/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 10:36:36    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 [2.0]                                                                      
      Hypertrophy                                                                                          1 [1.0]                  
   Thyroid Gland                                      (10)         (10)         (10)         (10)         (10)                      
      C-Cell, Hyperplasia                              1 [2.0]                                                                      
      Follicular Cell, Hypertrophy                     1 [1.0]      5 [1.8]      1 [1.0]      4 [2.0]      3 [1.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)         (10)                      
      Atrophy                                         10 [3.8]      9 [3.8]      9 [4.0]      8 [3.8]      9 [3.9]                  
   Uterus                                             (10)         (10)         (10)         (10)         (10)                      
      Inflammation, Suppurative                        4 [1.3]                   1 [2.0]                   2 [1.0]                  
      Metaplasia, Squamous                             8 [1.9]      9 [1.4]      8 [1.9]      8 [1.9]      8 [1.8]                  
      Endometrium, Hyperplasia, Cystic                 2 [3.5]                   1 [4.0]                   2 [4.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                   (1)                                                 
      Metaplasia, Squamous                                                       1 [1.0]                                            
   Spleen                                             (10)                                                (10)                      
      Pigmentation                                    10 [1.4]                                            10 [1.4]                  
   Thymus                                             (10)         (10)         (10)         (10)         (9)                       
      Atrophy                                                                    3 [1.3]      7 [1.9]      7 [2.1]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/22/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 10:36:36    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)         (10)                      
      Hemorrhage                                                                              1 [2.0]                               
      Infiltration Cellular, Histiocyte                1 [1.0]      1 [1.0]      1 [1.0]                   1 [1.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                                                                    (1)                                    
      Inflammation, Chronic Active                                                            1 [3.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------