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TDMS Study 96007-04 Pathology Tables

NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03
Route: GAVAGE                                                                                                     Time: 10:45:22

                                                      53 WEEK SSAC/FINAL#1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFDIOXINMIX

       Lock Date:  09/12/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     06/16/99 - 06/19/99

       Treatment Groups:       Include 001    TERT.MIXCONTROL
                               Include 002    TERT.MIXTEQ=10
                               Include 003    TERT.MIXTEQ=22
                               Include 004    TERT.MIXTEQ=46
                               Include 005    TERT.MIXTEQ=100
































                                                              Page   1


NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    TERT.MIX                               | 1| 1| 3| 3| 3| 3| 4| 4| 5| 5| 5| 7| 7|                                   |      L     |
    CONTROL                                | 2| 4| 6| 7| 8| 9| 0| 8| 1| 3| 5| 1| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +     +  +  +                                          |   8        |
      Basophilic Focus                     |                            X                                             |      1     |
      Clear Cell Focus                     |          X                                                               |      1     |
      Inflammation                         |       1  1  1  1  1     1  1  1                                          |      8  1.0|
      Mixed Cell Focus                     |             X                 X                                          |      2     |
      Mixed Cell Focus, Multiple           |                            X                                             |      1     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +  +     +  +  +                                          |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +  +  +     +  +  +                                          |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +  +  +     +  +  +                                          |   8        |
      Cyst, Squamous                       |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +  +     +  +  +                                          |   8        |
      Degeneration, Cystic                 |                2                                                         |      1  2.0|
      Hypertrophy                          |          2     2              1                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |       +  +  +  +  +     +  +  +                                          |   8        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +  +  +     +  +  +                                          |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +  +  +     +  +  +                                          |   8        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +     +  +  +                                          |   8        |
      Follicular Cell, Hypertrophy         |                   1     1                                                |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    TERT.MIX                               | 1| 1| 3| 3| 3| 3| 4| 4| 5| 5| 5| 7| 7|                                   |      L     |
    CONTROL                                | 2| 4| 6| 7| 8| 9| 0| 8| 1| 3| 5| 1| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +  +     +  +  +                                          |   8        |
      Atrophy                              |       4  4  4  3  4     4  4  4                                          |      8  3.9|
      Inflammation, Suppurative            |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +     +  +  +                                          |   8        |
      Inflammation, Suppurative            |          1                                                               |      1  1.0|
      Metaplasia, Squamous                 |       2  3  2  3  2     2  2  1                                          |      8  2.1|
      Endometrium, Hyperplasia, Cystic     |       1  2     3        2  1  1                                          |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |       +  +  +  +  +     +  +  +                                          |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +  +     +  +  +                                          |   8        |
      Pigmentation                         |       1  2  1  2  2     2  2  1                                          |      8  1.6|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +  +     +  +  +                                          |   8        |
      Atrophy                              |          2        2           2                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |       +  +  +  +  +     +  +  +                                          |   8        |
      Cyst                                 |             1     1     1                                                |      3  1.0|
      Hyperplasia                          |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    TERT.MIX                               | 1| 1| 3| 3| 3| 3| 4| 4| 5| 5| 5| 7| 7|                                   |      L     |
    CONTROL                                | 2| 4| 6| 7| 8| 9| 0| 8| 1| 3| 5| 1| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    |       +  +  +  +  +     +  +  +                                          |   8        |
      Infiltration Cellular, Histiocyte    |       2  1     1  1     1     1                                          |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 6| 6| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                   |      A     |
    TERT.MIX                               | 1| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 9|                                   |      L     |
    TEQ=10                                 | 8| 1| 2| 3| 4| 5| 8| 2| 4| 6| 7| 9| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +           +  +  +                                       |   8        |
      Clear Cell Focus                     |                X                                                         |      1     |
      Eosinophilic Focus, Multiple         |                               X                                          |      1     |
      Inflammation                         |    1  1  1  1  1           1  1  1                                       |      8  1.0|
      Mixed Cell Focus                     |       X                       X                                          |      2     |
      Mixed Cell Focus, Multiple           |    X        X                                                            |      2     |
      Pigmentation                         |       1  1                 1  1                                          |      4  1.0|
      Hepatocyte, Hypertrophy              |          1     1           2  1  1                                       |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +           +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +           +  +  +                                       |   8        |
      Hypertrophy                          |    1  1     1  1           1  1  1                                       |      7  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +           +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +           +  +  +                                       |   8        |
      Follicular Cell, Hypertrophy         |                            1  2                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +           +  +  +                                       |   8        |
      Atrophy                              |    4  4  4  4  4           4  4  4                                       |      8  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +           +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 6| 6| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                   |      A     |
    TERT.MIX                               | 1| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 9|                                   |      L     |
    TEQ=10                                 | 8| 1| 2| 3| 4| 5| 8| 2| 4| 6| 7| 9| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Metaplasia, Squamous                 |    2  3  2  3  2           1  2  2                                       |      8  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +           +  +  +                                       |   8        |
      Atrophy                              |    1  1  2  2  2           2  2                                          |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +           +  +  +                                       |   8        |
      Infiltration Cellular, Histiocyte    |    1     1  1              1  1                                          |      5  1.0|
      Inflammation                         |          1                                                               |      1  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    TERT.MIX                               | 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 5| 7| 9|                                   |      L     |
    TEQ=22                                 | 6| 8| 0| 1| 5| 1| 2| 3| 4| 5| 3| 7| 6|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +  +  +                                             |   8        |
      Eosinophilic Focus                   |                X                                                         |      1     |
      Inflammation                         | 1  2  1        1  1  1  1  1                                             |      8  1.1|
      Mixed Cell Focus                     | X              X     X     X                                             |      4     |
      Mixed Cell Focus, Multiple           |    X  X           X                                                      |      3     |
      Pigmentation                         | 1  2  1        1  1  1  2  1                                             |      8  1.3|
      Hepatocyte, Hypertrophy              | 1  1           2  1  2  2  1                                             |      7  1.4|
      Hepatocyte, Multinucleated           |       1           1        1                                             |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +  +  +                                             |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +        +  +  +  +  +                                             |   8        |
      Hyperplasia                          |                2  2                                                      |      2  2.0|
      Hypertrophy                          | 1  1  1                 1  1                                             |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +                                             |   8        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +  +  +                                             |   8        |
      C-Cell, Hyperplasia                  |    1                                                                     |      1  1.0|
      Follicular Cell, Hypertrophy         | 1                 1        1                                             |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +  +  +  +  +                                             |   8        |
      Atrophy                              | 4  4  4        4  4  4  4  4                                             |      8  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    TERT.MIX                               | 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 5| 7| 9|                                   |      L     |
    TEQ=22                                 | 6| 8| 0| 1| 5| 1| 2| 3| 4| 5| 3| 7| 6|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +  +  +  +  +                                             |   8        |
      Metaplasia, Squamous                 | 2  2  2        2  2  3  2  2                                             |      8  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +  +  +  +  +                                             |   8        |
      Atrophy                              | 1  3  2        2  2  2  2  2                                             |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |    +                                                                     |   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    |                         +                                                |   1        |
      Ulcer                                |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +  +  +                                             |   8        |
      Infiltration Cellular, Histiocyte    | 1  1           1  1  1                                                   |      5  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |    2                 1                                                   |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    TERT.MIX                               | 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 5| 7| 9|                                   |      L     |
    TEQ=22                                 | 6| 8| 0| 1| 5| 1| 2| 3| 4| 5| 3| 7| 6|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Kidney                                  |    +                                                                     |   1        |
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
      Nephropathy                          |    1                                                                     |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |      A     |
    TERT.MIX                               | 3| 3| 3| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9|                                   |      L     |
    TEQ=46                                 | 2| 6| 8| 2| 6| 7| 8| 9| 0| 1| 6| 7| 8|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +  +  +  +  +     +  +  +                                    |   8        |
      Cholangiofibrosis                    |                1                    1                                    |      2  1.0|
      Fatty Change, Focal                  |             1     1     1                                                |      3  1.0|
      Inflammation                         |             2  1  2  1  1     2  1  1                                    |      8  1.4|
      Mixed Cell Focus                     |                                     X                                    |      1     |
      Mixed Cell Focus, Multiple           |             X  X  X  X  X                                                |      5     |
      Pigmentation                         |             1  1  1  1  1     1  1  1                                    |      8  1.0|
      Toxic Hepatopathy                    |                1        2           1                                    |      3  1.3|
      Bile Duct, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                     1                                    |      1  1.0|
      Hepatocyte, Hypertrophy              |             2  2  1  1  2     2  1  1                                    |      8  1.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |             +  +  +  +  +     +  +  +                                    |   8        |
      Inflammation, Chronic Active         |                                  3                                       |      1  3.0|
      Acinus, Atrophy                      |                                  2                                       |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    |             1     1                                                      |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |                         +                                                |   1        |
      Developmental Malformation           |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |             +  +  +  +  +     +  +  +                                    |   8        |
      Hyperplasia                          |                                  1                                       |      1  1.0|
      Hypertrophy                          |                   1  1        1                                          |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +  +  +  +  +     +  +  +                                    |   8        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |             +  +  +  +  +     +  +  +                                    |   8        |
      Follicular Cell, Hypertrophy         |                      1  3           1                                    |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |      A     |
    TERT.MIX                               | 3| 3| 3| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9|                                   |      L     |
    TEQ=46                                 | 2| 6| 8| 2| 6| 7| 8| 9| 0| 1| 6| 7| 8|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |             +  +  +  +  +     +  +  +                                    |   8        |
      Atrophy                              |                4     4  4     4  4  4                                    |      6  4.0|
      Cyst                                 |                                  2                                       |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |             +  +  +  +  +     +  +  +                                    |   8        |
      Metaplasia, Squamous                 |                2     3  1     3  4  2                                    |      6  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |             +  +  +  +  +     +  +  +                                    |   8        |
      Atrophy                              |             4  3  3  2  3     4  4  4                                    |      8  3.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |             +  +  +  +  +     +  +  +                                    |   8        |
      Infiltration Cellular, Histiocyte    |             1  1        1           1                                    |      4  1.0|
      Inflammation, Chronic Active         |                      1                                                   |      1  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |             1  1  1              1                                       |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |      A     |
    TERT.MIX                               | 3| 3| 3| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9|                                   |      L     |
    TEQ=46                                 | 2| 6| 8| 2| 6| 7| 8| 9| 0| 1| 6| 7| 8|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  |                               +                                          |   1        |
      Inflammation, Chronic Active         |                               3                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    TERT.MIX                               | 0| 0| 0| 0| 0| 3| 5| 5| 5| 6| 7| 7| 9|                                   |      L     |
    TEQ=100                                | 1| 2| 3| 4| 5| 1| 7| 8| 9| 6| 3| 5| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +                                                |   8        |
      Basophilic Focus                     |       X                                                                  |      1     |
      Cholangiofibrosis                    |                         1                                                |      1  1.0|
      Clear Cell Focus                     |                      X                                                   |      1     |
      Eosinophilic Focus                   |                         X                                                |      1     |
      Fatty Change, Diffuse                |             1     1                                                      |      2  1.0|
      Fatty Change, Focal                  | 1  2  1  1                                                               |      4  1.3|
      Inflammation                         | 2  2  2  2  2     1  2  2                                                |      8  1.9|
      Mixed Cell Focus, Multiple           | X  X  X     X     X  X  X                                                |      7     |
      Pigmentation                         | 3  2  2  2  2     2  2  1                                                |      8  2.0|
      Regeneration                         |    X                                                                     |      1     |
      Toxic Hepatopathy                    | 3  2  1  1  1     2  1  2                                                |      8  1.6|
      Bile Duct, Fibrosis                  |          1                                                               |      1  1.0|
      Bile Duct, Hyperplasia               | 1  1  1     1     1  1                                                   |      6  1.0|
      Bile Duct, Inflammation, Chronic     |                                                                          |            |
          Active                           |          1                                                               |      1  1.0|
      Hepatocyte, Hypertrophy              | 3  3  2  2  3     3  2  2                                                |      8  2.5|
      Hepatocyte, Multinucleated           | 1  2  2  2  2     2  2  1                                                |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +                                                |   8        |
      Basophilic Focus                     |       X                                                                  |      1     |
      Inflammation, Chronic Active         |                      1                                                   |      1  1.0|
      Acinus, Atrophy                      |                      2                                                   |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    | 1  1     2  2     2  2  1                                                |      7  1.6|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +                                                |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    TERT.MIX                               | 0| 0| 0| 0| 0| 3| 5| 5| 5| 6| 7| 7| 9|                                   |      L     |
    TEQ=100                                | 1| 2| 3| 4| 5| 1| 7| 8| 9| 6| 3| 5| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +     +  +  +                                                |   8        |
      Degeneration, Cystic                 |                   1  2                                                   |      2  1.5|
      Hyperplasia                          |       2  2                                                               |      2  2.0|
      Hypertrophy                          |       1     1     2  3  1                                                |      5  1.6|
      Vacuolization Cytoplasmic            |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +     +  +  +                                                |   8        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +                                                |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +                                                |   8        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +                                                |   8        |
      Follicular Cell, Hypertrophy         | 3  2        3        1                                                   |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +  +  +                                                |   8        |
      Atrophy                              | 4  4  4  3  4     4  4  3                                                |      8  3.8|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +                                                |   8        |
      Metaplasia, Squamous                 | 2  2  1     4     2  2  2                                                |      7  2.1|
      Endometrium, Hyperplasia, Cystic     |       4           4                                                      |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +     +  +  +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +                                                |   8        |
      Pigmentation                         | 2  1  4  2  2     2  2  2                                                |      8  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 04/22/03    
Route: GAVAGE                                                                                                     Time: 10:45:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 7| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    TERT.MIX                               | 0| 0| 0| 0| 0| 3| 5| 5| 5| 6| 7| 7| 9|                                   |      L     |
    TEQ=100                                | 1| 2| 3| 4| 5| 1| 7| 8| 9| 6| 3| 5| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  I  +  +  +     +  +  M                                                |   6        |
      Atrophy                              | 4     3  3  4     4  4                                                   |      6  3.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +  +  +                                                |   8        |
      Hyperplasia                          |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +                                                |   8        |
      Infiltration Cellular, Histiocyte    |       1  1  1     1  1  1                                                |      6  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 1     2  2  1     1  1                                                   |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
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