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TDMS Study 96007-04 Pathology Tables

NTP Experiment-Test: 96007-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03
Route: GAVAGE                                                                                                     Time: 12:03:26

                                                          FINAL#4/RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFDIOXINMIX

       Lock Date:  09/12/01

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 96007-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03  
Route: GAVAGE                                                                                                     Time: 12:03:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                     
                                                   CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          98           98           98           98           98                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                26           25           22           25           33                        
    Natural Death                                     11            5            6            4           10                        
    Dosing Accident                                                              1            1            2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                16           23           24           23            8                        
                                                                                                                                    
  Animals Examined Microscopically                    53           53           53           53           53                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (53)         (52)         (53)         (53)         (51)                      
      Carcinoma                                        1 (2%)                                                                       
   Intestine Large, Rectum                            (52)         (53)         (53)         (53)         (52)                      
      Polyp Adenomatous                                                          1 (2%)                                             
      Schwannoma Malignant, Metastatic, Uterus                                                1 (2%)                                
   Intestine Large, Cecum                             (51)         (53)         (53)         (53)         (51)                      
   Intestine Small, Duodenum                          (52)         (53)         (53)         (53)         (52)                      
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (52)         (53)         (53)         (53)         (50)                      
      Leiomyosarcoma                                   1 (2%)                    1 (2%)                                             
   Intestine Small, Ileum                             (52)         (53)         (53)         (53)         (50)                      
   Liver                                              (53)         (53)         (53)         (53)         (51)                      
      Cholangiocarcinoma                                                         2 (4%)       5 (9%)       5 (10%)                  
      Cholangiocarcinoma, Multiple                                                            2 (4%)       4 (8%)                   
      Hepatocellular Adenoma                                        1 (2%)       1 (2%)       1 (2%)       9 (18%)                  
      Hepatocellular Adenoma, Multiple                                                                     2 (4%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Mesentery                                                       (1)          (2)          (6)          (8)                       
      Lipoma                                                                                  1 (17%)                               
   Oral Mucosa                                        (10)         (18)         (19)         (29)         (31)                      
      Gingival, Squamous Cell Carcinoma                1 (10%)      1 (6%)                                 2 (6%)                   
   Pancreas                                           (52)         (53)         (53)         (53)         (51)                      
      Acinus, Adenoma                                                            2 (4%)                                             
      Acinus, Carcinoma                                             1 (2%)                    2 (4%)                                
   Salivary Glands                                    (53)         (53)         (53)         (53)         (53)                      
      Carcinoma                                                     1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Skin                                                               1 (2%)                   
   Stomach, Forestomach                               (53)         (53)         (53)         (53)         (52)                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03  
Route: GAVAGE                                                                                                     Time: 12:03:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                     
                                                   CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Glandular                                 (53)         (53)         (53)         (53)         (52)                      
   Tongue                                             (1)                                                 (1)                       
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                       1 (100%)                                                                     
   Tooth                                              (24)         (23)         (27)         (37)         (30)                      
      Peridontal Tissue, Fibrosarcoma                  1 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (53)         (53)         (53)         (52)         (53)                      
      Aorta, Adventitia, Carcinoma, Metastatic,                                                                                     
           Mammary Gland                               1 (2%)                                                                       
   Heart                                              (53)         (53)         (53)         (52)         (53)                      
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                    1 (2%)                                                          
      Schwannoma Malignant                             2 (4%)                                 1 (2%)       3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (52)         (53)         (53)         (53)         (51)                      
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Adrenal Medulla                                    (52)         (53)         (53)         (53)         (51)                      
      Pheochromocytoma Benign                          4 (8%)       3 (6%)       4 (8%)       4 (8%)       1 (2%)                   
      Bilateral, Pheochromocytoma Benign               1 (2%)       1 (2%)                                                          
   Islets, Pancreatic                                 (52)         (53)         (53)         (53)         (51)                      
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (50)         (50)         (49)         (47)         (52)                      
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (53)         (53)         (53)         (53)         (53)                      
      Carcinoma                                                                  1 (2%)                                             
      Pars Distalis, Adenoma                          28 (53%)     29 (55%)     22 (42%)     20 (38%)     10 (19%)                  
   Thyroid Gland                                      (53)         (53)         (51)         (52)         (51)                      
      Bilateral, C-Cell, Adenoma                       2 (4%)       2 (4%)       3 (6%)       1 (2%)                                
      Bilateral, Follicular Cell, Carcinoma                                      1 (2%)                                             
      C-Cell, Adenoma                                 15 (28%)      8 (15%)     15 (29%)      8 (15%)      5 (10%)                  
      C-Cell, Carcinoma                                2 (4%)                                 1 (2%)       1 (2%)                   
      Follicular Cell, Adenoma                                                   1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03  
Route: GAVAGE                                                                                                     Time: 12:03:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                     
                                                   CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (52)         (52)         (53)         (53)         (51)                      
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                    1 (2%)                                                          
      Granulosa Cell Tumor Malignant                                             1 (2%)                    1 (2%)                   
      Granulosa Cell Tumor Benign                                                1 (2%)       1 (2%)                                
   Uterus                                             (52)         (53)         (53)         (53)         (51)                      
      Carcinoma                                                     1 (2%)       2 (4%)       2 (4%)       1 (2%)                   
      Hemangiosarcoma                                                                                      1 (2%)                   
      Leiomyoma                                                                  2 (4%)                                             
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Stromal                                    3 (6%)       1 (2%)       2 (4%)       3 (6%)       2 (4%)                   
      Polyp Stromal, Multiple                          1 (2%)                    1 (2%)                                             
      Schwannoma Malignant                             1 (2%)                    1 (2%)       2 (4%)       1 (2%)                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Cervix, Carcinoma                                1 (2%)                                                                       
      Cervix, Squamous Cell Carcinoma                               1 (2%)                                 1 (2%)                   
      Serosa, Carcinoma, Metastatic, Uterus            1 (2%)                                                                       
   Vagina                                                                                    (1)                                    
      Schwannoma Malignant                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (53)         (53)         (53)         (53)                      
   Lymph Node                                         (4)          (1)          (2)          (9)          (11)                      
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                                       1 (11%)                               
   Lymph Node, Mandibular                             (53)         (53)         (53)         (53)         (53)                      
   Lymph Node, Mesenteric                             (52)         (53)         (53)         (53)         (50)                      
   Spleen                                             (52)         (53)         (53)         (53)         (51)                      
   Thymus                                             (52)         (48)         (50)         (53)         (50)                      
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03  
Route: GAVAGE                                                                                                     Time: 12:03:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                     
                                                   CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (53)         (53)         (53)         (52)                      
      Adenoacanthoma                                                             1 (2%)                                             
      Adenolipoma                                                                1 (2%)                                             
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        5 (9%)       6 (11%)      3 (6%)       5 (9%)       1 (2%)                   
      Carcinoma, Multiple                              1 (2%)                                                                       
      Fibroadenoma                                    21 (40%)     17 (32%)     19 (36%)     20 (38%)     15 (29%)                  
      Fibroadenoma, Multiple                          13 (25%)     10 (19%)     16 (30%)      8 (15%)      3 (6%)                   
   Skin                                               (53)         (53)         (53)         (53)         (53)                      
      Fibroma                                          1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
      Fibrosarcoma                                     1 (2%)                                 1 (2%)                                
      Pilomatrixoma                                                                           1 (2%)                                
      Schwannoma Malignant                                                                                 1 (2%)                   
      Schwannoma Malignant, Metastatic, Uterus                                                1 (2%)                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
      Fibrous Histiocytoma                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (53)         (53)         (53)         (53)                      
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
      Granular Cell Tumor Malignant                                              1 (2%)                                             
      Medulloblastoma Mal                                           1 (2%)       1 (2%)                                             
      Oligodendroglioma Malignant                                                1 (2%)                                             
      Meninges, Meningioma Malignant                                1 (2%)                                                          
   Spinal Cord                                        (1)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (53)         (53)         (53)         (53)                      
      Alveolar/Bronchiolar Adenoma                                               1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Mammary Gland             3 (6%)       1 (2%)                    2 (4%)                                
      Carcinoma, Metastatic, Uterus                    1 (2%)                                                                       
      Carcinoma, Metastatic, Adrenal Cortex                                      1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03  
Route: GAVAGE                                                                                                     Time: 12:03:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                     
                                                   CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Cystic Keratinizing Epithelioma                                                         2 (4%)       9 (17%)                  
      Cystic Keratinizing Epithelioma, Multiple                                                           11 (21%)                  
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                    1 (2%)                                                          
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Schwannoma Malignant, Metastatic, Skin                                                               1 (2%)                   
      Mediastinum, Carcinoma, Metastatic, Mammary                                                                                   
          Gland                                        1 (2%)                                                                       
      Mediastinum, Fibrous Histiocytoma,                                                                                            
          Metastatic, Skeletal Muscle                               1 (2%)                                                          
   Nose                                               (53)         (53)         (53)         (53)         (53)                      
      Schwannoma Malignant                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (53)         (53)         (52)         (53)         (53)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (52)         (53)         (53)         (53)         (51)                      
      Hemangiosarcoma                                                            1 (2%)                                             
      Nephroblastoma                                   1 (2%)                                                                       
      Bilateral, Renal Tubule, Carcinoma               1 (2%)                                                                       
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
      Transitional Epithelium, Papilloma                                                      1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(53)        *(53)        *(53)        *(53)        *(53)                      
      Adenolipoma                                                                1 (2%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Lymphoma Malignant                               2 (4%)       1 (2%)                    1 (2%)       2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03  
Route: GAVAGE                                                                                                     Time: 12:03:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                     
                                                   CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            51          46          50          50          45                           
     Total Primary Neoplasms                          115          94         118          99          93                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45          43          46          43          39                           
     Total Benign Neoplasms                            92          77          97          75          68                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          14          19          21          21                           
     Total Malignant Neoplasms                         23          17          21          23          25                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7           2           2           4           1                           
     Total Metastatic Neoplasm                         11           5           2           5           2                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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