National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5340

TDMS Study 96007-04 Pathology Tables

NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03
Route: GAVAGE                                                                                                     Time: 12:07:43

                                                          FINAL#4/RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFDIOXINMIX

       Lock Date:  09/12/01

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All



































                                                              Page   1


NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|             
                             DAY ON TEST   | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|             
                                           | 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2              1      |             
      Basophilic Focus                     | X  X              X                       X                 X            |             
      Basophilic Focus, Multiple           |                         X     X        X           X  X  X               |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                X                                                         |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Fatty Change, Diffuse                |                                     3                                    |             
      Fatty Change, Focal                  |                                                                   2     1|             
      Hematopoietic Cell Proliferation     | 1     1  1           1     1     1        1        1           1         |             
      Inflammation                         |    1  1     2  1  1     1  1  1  1  1  1  1  1     1  1     1  1  1  1   |             
      Mixed Cell Focus                     |                                                          X     X         |             
      Mixed Cell Focus, Multiple           |                            X              X     X     X     X     X      |             
      Necrosis                             |                                              1                           |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Cyst                      |                                                       3                  |             
      Bile Duct, Dilatation                |                                                                          |             
      Bile Duct, Fibrosis                  |                                                       1                  |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Degeneration          |                                              1                           |             
      Hepatocyte, Hypertrophy              |    1                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|             
                             DAY ON TEST   | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|             
                                           | 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                   +                 +        +  +        +     +         |             
      Gingival, Hyperplasia, Squamous      |                   1                          2           1     2         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic Active         |                               2                                   1      |             
      Acinus, Atrophy                      |                                                                   1      |             
      Acinus, Hyperplasia                  |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation                         |                                     1                                    |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Squamous                |                                        2                                 |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                     +                                    |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                   +        +        +        +           +     +     +  +|             
      Peridontal Tissue, Inflammation      |                   1        1        2        1           1     2     1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1                                         1        1  1           1     1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|             
                             DAY ON TEST   | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|             
                                           | 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2           1        1              2     1     2                  |             
      Degeneration, Cystic                 |                            2  3                       3                  |             
      Hyperplasia                          |                   1     2     2                    3                     |             
      Hypertrophy                          | 2     2     2  2  3     2  4  3  2  2     1  1  2  2  3  1  2     1      |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                   1                                                      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2           2     3                 2        2                    3|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                   2                    1               |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |          2                                                               |             
      Pars Distalis, Hyperplasia           | 3           2     3        3        3           3     3     2     2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  2        1              3  2           3     3        1        2      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Hypertrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1  2  2  2     2  2  1  1  1  2  1  2  2  2  1  1  1  2  2  2  1  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|             
                             DAY ON TEST   | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|             
                                           | 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Duct, Cyst                           |    1  3  3  2        3  3  3  3  2  3     2  2     2        3  3  2  1  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4     4  4  4     4  4  4     4  4  4  4  4  4  4  4  4  4     3  4|             
      Cyst                                 |                   3              2                                2      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                            2                                             |             
      Inflammation, Suppurative            | 2           1                                                            |             
      Metaplasia, Squamous                 | 2     2     2     2     2  4           2     1  2  2           2  1      |             
      Cervix, Hyperplasia, Stromal         |       4                                                                  |             
      Endometrium, Hyperplasia, Cystic     | 3     2     1  1  1     2     1  1  1  1  2     3  2  2        1  1     1|             
      Epithelium, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3     4  4  3     3  4  3        4        3  3  3  3     3     4     4  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Pancreatic, Ectasia                  |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             | 2              2  2     2     2  3  2  2  2     3     2  2  2     2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             2                                                            |             
      Hemorrhage                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2     3  2  2     2  3  2  1     3        1  3  3  2  2  1  1  3  1  1  1|             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 1  1     1  1  3  1     2  2  3  1  2  2        2  1  1  2  1  1  2  1  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|             
                             DAY ON TEST   | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|             
                                           | 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2     2           2  3  2     3  2     3  4     2  2  2  1  2      |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1     1                 1  1     1  1                 1  1     3     1|             
      Inflammation, Granulomatous          |    1                                                     1     2         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                          3               |             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       |                                                          2               |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 3  1     2     3  2     2  2  2  1  1  1     1  2  2  1  2  1     1     1|             
      Inflammation                         |       2                                         1                        |             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2                          1  1                 1           1            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                           1                              |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|             
                             DAY ON TEST   | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|             
                                           | 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1                 1  1           2     1     1           1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |    2                                            1                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1  1  1        1  1  1  1  2  1  1  1  1  1  1     1  1  1  1     1  1  1|             
      Nephropathy                          |                1  1     1  1  1     1  1  1              2        1     2|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                                                                          |             
      Renal Tubule, Necrosis               |                   2                                                      |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1                    1              1  1  1                        |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|             
                                           | 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
    CONTROL                                | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                           |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Basophilic Focus                     |                X              X        X           X                     |             
      Basophilic Focus, Multiple           | X  X        X                                            X     X     X  X|             
      Clear Cell Focus, Multiple           |                         X                                                |             
      Degeneration, Cystic                 |                      1                                                   |             
      Eosinophilic Focus                   |                X                                            X        X   |             
      Eosinophilic Focus, Multiple         |                                                          X               |             
      Fatty Change, Diffuse                |                               3                                          |             
      Fatty Change, Focal                  |                                        1                                 |             
      Hematopoietic Cell Proliferation     | 2  1                          1           1  1                 1         |             
      Inflammation                         | 1     1  2     1     1        1  1              1  1  1  1  1     1  1  1|             
      Mixed Cell Focus                     |                                                    X              X      |             
      Mixed Cell Focus, Multiple           | X              X        X        X     X        X     X  X  X        X   |             
      Necrosis                             |          2                                                               |             
      Pigmentation                         |             1        2        2                                         1|             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Dilatation                |                                        1                                 |             
      Bile Duct, Fibrosis                  |             2                                                        2   |             
      Bile Duct, Hyperplasia               |                                                             1        2   |             
      Centrilobular, Degeneration          |                                           2                              |             
      Hepatocyte, Hypertrophy              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|             
                                           | 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
    CONTROL                                | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Serosa, Inflammation, Chronic        |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +                                   +  +                        |             
      Gingival, Hyperplasia, Squamous      |          2                                   1  2                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      | 1                                                                        |             
      Acinus, Hyperplasia                  |                               2                             1            |             
      Acinus, Vacuolization Cytoplasmic    |                      1                                                   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3                                          |             
      Inflammation                         |                               3                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               3                                          |             
      Hyperplasia, Squamous                |    2                    2     3                                          |             
      Inflammation                         |                               2                                          |             
      Mineralization                       |    2                                                                     |             
      Ulcer                                |    3                          3                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                           2                              |             
      Mineralization                       |    2                                                  2                  |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +        +        +  +  +     +  +     +  +  +  +        +     +  +      |             
      Peridontal Tissue, Inflammation      | 1        1        1  1  1        1     1  1  1  1        1     1  1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1                                            1     1  1  1            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|             
                                           | 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
    CONTROL                                | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Inflammation, Suppurative            |          3                                                               |             
      Thrombosis                           |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2        2  2  1        2        2     2                 1        2      |             
      Degeneration, Cystic                 |    3                 3  3     2                    2                     |             
      Hyperplasia                          |             3  3  3  1  2        3           4                          3|             
      Hypertrophy                          | 1  3  1     2  2  2  3  4     3  2  2  2  2  1  2  2  2  2  2  2  3  2  2|             
      Necrosis                             |          3                          3                                    |             
      Vacuolization Cytoplasmic            |                         1        2           1                    1      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3              2  2     1               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2     2                                1               |             
      Cyst                                 |                      2                                                   |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                   3                 3  2  3           1  1  3            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2                       2        2  3  1  3     2  3  2  3  2  2  3  3   |             
      Follicular Cell, Hyperplasia         |                                                 1                        |             
      Follicular Cell, Hypertrophy         |                               3  1        1              1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2     1  1  2     2  2  2        1  2     2        2     2  3  1  3  1  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|             
                                           | 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
    CONTROL                                | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Duct, Cyst                           | 3  3  1  1  3  2     4  3     1     2     3     2  1  1  1  3     3  1  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4     4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Cyst                                 |                3     3                             2     3        3      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          3                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |          3           1                 1                 3               |             
      Metaplasia, Squamous                 |                      3  2     1     3     1  1        2  3  1            |             
      Cervix, Hyperplasia, Stromal         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3     1        2  2  4  2        3  1  1  1  1  2     3  2  2  2  3  3  3|             
      Epithelium, Necrosis                 |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  3     4  2  2  2  3  2  4  3     4     4  3  2        3  3           2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +           +                       +                           |             
      Lumbar, Hyperplasia, Plasma Cell     |                      2                                                   |             
      Pancreatic, Ectasia                  |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |          3                                                               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             | 2     2  2  2  2  2  3  2     2  2  2           2        2  2        2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                         3|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  3           1  2  1        1  1  2  2  3  2  1  1  1  1  1  3  1  1  1|             
      Necrosis                             |          3                                                               |             
      Pigmentation                         |    1  2  1  2  2  1  2        2  1  1  1  1     1  2  1  1  1  1  1  1  2|             
      Lymphoid Follicle, Atrophy           |                                                                2         |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|             
                                           | 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
    CONTROL                                | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3  3  3  3  2  1  2        2     3     3           1  2     2  2  1  2|             
      Cyst                                 |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  1     1  2        1                       1        1  1  1        1|             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                          |             
      Hydrocephalus                        |                                                                         1|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                              +                           |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 3  2  2  1  2     2  1  2  2  2     2  2  2  1  2  3  1  3  2  3     3  3|             
      Inflammation                         |                      1                                         2         |             
      Metaplasia, Squamous                 |                                                          2     2         |             
      Alveolar Epithelium, Hyperplasia     | 2     1  1  1     1     1     1        1        1  1  1  2  2  2     2  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|             
                                           | 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    TERT.MIX                               | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
    CONTROL                                | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |             3                                                            |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                              2  2     1  1     2        1|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |          2                    1                                      1   |             
      Mineralization                       |    1  1     1  1  1  1        1  1  1  1  1  1     1  1  1  1           1|             
      Nephropathy                          |    1  1  1  1  1  1           1     1  1        1  1           1  1  1   |             
      Pelvis, Dilatation                   |          3                                                               |             
      Pelvis, Inflammation                 |                                              2                       2   |             
      Renal Tubule, Necrosis               |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                     2           2              2     2   |             
                                           |__________________________________________________________________________|             
   Ureter                                  |          +                                                               |             
      Cyst                                 |          3                                                               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1        1        1                                      1   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6|                                                                 |            |
                             DAY ON TEST   | 8| 6| 2|                                                                 |            |
                                           | 4| 9| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    CONTROL                                | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      3  1.7|
      Basophilic Focus                     |                                                                          |      9     |
      Basophilic Focus, Multiple           |    X  X                                                                  |     15     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      4     |
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Fatty Change, Diffuse                | 1                                                                        |      3  2.3|
      Fatty Change, Focal                  |                                                                          |      3  1.3|
      Hematopoietic Cell Proliferation     |       1                                                                  |     16  1.1|
      Inflammation                         | 1  1                                                                     |     36  1.1|
      Mixed Cell Focus                     |                                                                          |      4     |
      Mixed Cell Focus, Multiple           |    X                                                                     |     17     |
      Necrosis                             |       2                                                                  |      3  1.7|
      Pigmentation                         |                                                                          |      4  1.5|
      Bile Duct, Cyst                      |                                                                          |      1  3.0|
      Bile Duct, Dilatation                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6|                                                                 |            |
                             DAY ON TEST   | 8| 6| 2|                                                                 |            |
                                           | 4| 9| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    CONTROL                                | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Fibrosis                  |                                                                          |      3  1.7|
      Bile Duct, Hyperplasia               |                                                                          |      2  1.5|
      Centrilobular, Degeneration          |       2                                                                  |      3  1.7|
      Hepatocyte, Hypertrophy              |                                                                          |      1  1.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +                                                                        |  10        |
      Gingival, Hyperplasia, Squamous      | 1                                                                        |      8  1.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Degeneration                         | 2                                                                        |      1  2.0|
      Inflammation, Chronic Active         |       2                                                                  |      3  1.7|
      Acinus, Atrophy                      |       2                                                                  |      3  1.3|
      Acinus, Hyperplasia                  |                                                                          |      2  1.5|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Squamous                | 3                                                                        |      5  2.4|
      Inflammation                         | 3                                                                        |      2  2.5|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                | 3                                                                        |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +                                                                     |  24        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6|                                                                 |            |
                             DAY ON TEST   | 8| 6| 2|                                                                 |            |
                                           | 4| 9| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    CONTROL                                | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Peridontal Tissue, Inflammation      | 1  1                                                                     |     23  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |                                                                          |     11  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |     15  1.7|
      Degeneration, Cystic                 |    1                                                                     |      9  2.4|
      Hyperplasia                          |                                                                          |     12  2.5|
      Hypertrophy                          | 1  2  2                                                                  |     44  2.1|
      Necrosis                             |                                                                          |      2  3.0|
      Vacuolization Cytoplasmic            |       1                                                                  |      6  1.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Hyperplasia                          |                                                                          |     10  2.2|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      6  1.7|
      Cyst                                 |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |    3  2                                                                  |     18  2.5|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6|                                                                 |            |
                             DAY ON TEST   | 8| 6| 2|                                                                 |            |
                                           | 4| 9| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    CONTROL                                | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  |       3                                                                  |     24  2.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
      Follicular Cell, Hypertrophy         |                                                                          |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M                                                                  |  51        |
      Inflammation                         |    2                                                                     |     42  1.7|
      Duct, Cyst                           | 3  2                                                                     |     39  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
      Atrophy                              |    4                                                                     |     44  4.0|
      Cyst                                 |                                                                          |      8  2.6|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      6  1.8|
      Metaplasia, Squamous                 |                                                                          |     21  2.0|
      Cervix, Hyperplasia, Stromal         |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |    2                                                                     |     37  1.9|
      Epithelium, Necrosis                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 3  2  3                                                                  |     36  3.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   4        |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6|                                                                 |            |
                             DAY ON TEST   | 8| 6| 2|                                                                 |            |
                                           | 4| 9| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    CONTROL                                | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pancreatic, Ectasia                  | 3                                                                        |      1  3.0|
      Renal, Hyperplasia, Histiocytic      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Hyperplasia, Plasma Cell             |    2                                                                     |     31  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Hematopoietic Cell Proliferation     | 1  3  4                                                                  |     43  1.8|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         | 1  1  1                                                                  |     45  1.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  52        |
      Atrophy                              | 4     3                                                                  |     32  2.3|
      Cyst                                 |    3                                                                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Hyperplasia                          | 1     2                                                                  |     22  1.2|
      Inflammation, Granulomatous          |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6|                                                                 |            |
                             DAY ON TEST   | 8| 6| 2|                                                                 |            |
                                           | 4| 9| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    CONTROL                                | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Brain                                   | +  +  +                                                                  |  53        |
      Gliosis                              |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    |    2  2                                                                  |     43  1.9|
      Inflammation                         |                                                                          |      4  1.5|
      Metaplasia, Squamous                 |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |     21  1.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6|                                                                 |            |
                             DAY ON TEST   | 8| 6| 2|                                                                 |            |
                                           | 4| 9| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    CONTROL                                | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Kidney                                  | +  +  +                                                                  |  52        |
      Calculus Micro Observation Only      | 2                                                                        |      9  1.6|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      3  1.3|
      Mineralization                       | 1  1  1                                                                  |     41  1.0|
      Nephropathy                          |       1                                                                  |     26  1.1|
      Pelvis, Dilatation                   | 1                                                                        |      2  2.0|
      Pelvis, Inflammation                 |                                                                          |      2  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia | 2                                                                        |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
      Inflammation                         |    1                                                                     |     12  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|             
                                           | 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    TEQ=10                                 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X           X                                 |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |          X        X                 X  X  X     X     X                  |             
      Basophilic Focus, Multiple           | X                                            X     X     X  X     X      |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   | X                             X                                          |             
      Eosinophilic Focus, Multiple         |                                                    X                 X   |             
      Fatty Change, Diffuse                |       1        1                                   1           1         |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     | 1  1                       1           1     2  1              1         |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2     1  1  1  1  1  2  1  1|             
      Mixed Cell Focus                     |    X        X                                                  X         |             
      Mixed Cell Focus, Multiple           | X              X  X  X        X     X                 X  X        X     X|             
      Necrosis                             |                                                                          |             
      Pigmentation                         |       1  1  1  2  2        1              2  2  2  1  1  2  2  1  1  2   |             
      Toxic Hepatopathy                    |                                              1        1                  |             
      Bile Duct, Cyst                      |                                                                         3|             
      Bile Duct, Fibrosis                  |                                                                          |             
      Bile Duct, Hyperplasia               |       1                                      1                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|             
                                           | 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    TEQ=10                                 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Centrilobular, Degeneration          |                                                 3                    1   |             
      Hepatocyte, Hypertrophy              |    1        1        1  1     1  1           2  2  1  1  1  1        2  1|             
      Hepatocyte, Multinucleated           |                   1                       1  1        1        1  1      |             
      Oval Cell, Hyperplasia               |                                              1                           |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Artery, Inflammation, Chronic Active |                                              4                           |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +  +  +           +        +  +     +  +                 +            |             
      Gingival, Hyperplasia, Squamous      |    1  1  1           1        1  1     1  1                              |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                       1     1            |             
      Artery, Inflammation, Chronic Active |                                              2                           |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   1              2                                       |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +  +  +        +  +        +  +     +  +     +        +  +           +|             
      Peridontal Tissue, Inflammation      |    1  1  1        1  1        1  1     2  2     1           2           1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1           1           1  1  1     1           1     1     1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  2  2                 2     1  1        1  1     2  1  1        1     2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|             
                                           | 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    TEQ=10                                 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Atrophy                              |                2                                                         |             
      Degeneration, Cystic                 |                3  3                 3                    3              2|             
      Hyperplasia                          |    2           2              3  3  3        2  1  1     2        2      |             
      Hypertrophy                          | 2  2  1  3  2  4  4  2  1  1  2     2  1  2  2     3  2  4  1  1     2  3|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                              3                           |             
      Vacuolization Cytoplasmic            |          1  1                                   1  1     2     1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        2        2        1  3        4  3     3        1     1      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                   2                 1                       1            |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           | 2        2     2  2        3        2  3                                 |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  3  3  2           3        2  1        3  1        3  3        1     1|             
      Follicular Cell, Hypertrophy         |                      1           1     1              1     1        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2     2  1  1     1  3  3  1  3  2  3     1        2  2  3     2  2     1|             
      Duct, Cyst                           | 4     3           2     2  2  2  4  2  2  3     2  3  3  3        3  3  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  4     4  4  4  4  4  4  4  4  4  4  4  4     4  4  4  4  4  4     4|             
      Cyst                                 |       2  3                 2              2  3                 3     3   |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |          4                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|             
                                           | 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    TEQ=10                                 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                          2               |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |          3                 2                                             |             
      Metaplasia, Squamous                 |    2     4        1  3     4        1  2  2        2  2  2  2     2     1|             
      Ulcer                                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    1  2     3  3     2  2     1  4  3  3  1  1     2  2  3  2     2  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4     3           2  2  3     2     3     3  3  3  3  2  2  4     3   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                     2                                    |             
      Hyperplasia, Plasma Cell             | 2     2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  3  2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  1     1     1  1  2  1  3  1  1  1  1  1  3  1  2  1  1  1  2  1  3  1|             
      Pigmentation                         | 1  1  1  1  2  1  2  1  1  1  1  1  1  1  3  1  1  1  1  1  2  1  2  1  1|             
      Lymphoid Follicle, Atrophy           |                                                 3                        |             
      Red Pulp, Atrophy                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              | 2  4  2  4  2     3     3  2  4     3     2  3  4     2  3  2  2  2  4  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|             
                                           | 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    TEQ=10                                 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                               1  3              2                        |             
      Inflammation, Granulomatous          |    2                                      2                 2            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hair Follicle, Atrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   2      |             
      Hydrocephalus                        |                                           2  1                    1      |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                   +      |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2  2  2  2  2  2  2  2  1     1  1  1  2  3     2  2  3  3  1  2  2  1|             
      Inflammation                         |                                                                   2      |             
      Alveolar Epithelium, Hyperplasia     | 1  1  1  1     1  1     1  1  1        1  1        1        1           1|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |             1        3  1        1           2        2  3        2  2   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1                                1                     |             
      Respiratory Epithelium, Hyperplasia  |                            1                                             |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|             
                                           | 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    TEQ=10                                 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lens, Degeneration                   |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1                 1              1     1                       1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                         1                                      2         |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                      1                             1                     |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Nephropathy                          | 1  1  1  1  1  1  1  1        1  1  1  1  2  3           1     1  1     1|             
      Pelvis, Inflammation                 |                                                 1                        |             
      Transitional Epithelium, Hyperplasia |                                              1                 2         |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1                                                                 1  1|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|             
                                           | 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    TEQ=10                                 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                            1                          1                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                   X                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                 1   |             
      Basophilic Focus                     |          X  X                    X           X              X           X|             
      Basophilic Focus, Multiple           |    X  X           X                                   X           X      |             
      Cholangiofibrosis                    |                                                    1              1      |             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         |                                                       X     X  X  X  X   |             
      Fatty Change, Diffuse                |                                     1                                    |             
      Fatty Change, Focal                  |             2                                1  1              2         |             
      Hematopoietic Cell Proliferation     |          1  1        1              1  1              1     1     1     1|             
      Hyperplasia, Nodular                 |             X                                                            |             
      Inflammation                         | 1  2  1  1  1  1  1  2     2  1  1  1  1  1  1  1  1  1  1     1  1  1  1|             
      Mixed Cell Focus                     |                                  X                             X         |             
      Mixed Cell Focus, Multiple           | X  X     X  X     X     X  X           X        X  X     X  X     X  X  X|             
      Necrosis                             |                                                                          |             
      Pigmentation                         |    2     2  2     1  1        1  1        1  1  1  1     1  1     1  1  1|             
      Toxic Hepatopathy                    |                                           1                 1     1      |             
      Bile Duct, Cyst                      |    2                                               3                     |             
      Bile Duct, Fibrosis                  |             1           1                                                |             
      Bile Duct, Hyperplasia               | 2                                                                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|             
                                           | 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    TEQ=10                                 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Centrilobular, Degeneration          |                                                                          |             
      Hepatocyte, Hypertrophy              |       1     1  1              1  1     2  1  1  1     1     1     1  1   |             
      Hepatocyte, Multinucleated           |    1     1                                1                 1            |             
      Oval Cell, Hyperplasia               |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +        +                          +           +           +  +  +   |             
      Gingival, Hyperplasia, Squamous      |    2        3                          1           3           2  1  2   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               3                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Inflammation, Chronic Active |    3     1              3     1                          3               |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                           1           2                  |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +              +                    +  +  +                    +  +  +|             
      Peridontal Tissue, Inflammation      |    1                                   1  1  1                    2  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  1  2              1           1     1  1  1  1  1           1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1     3              2                          2  2                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|             
                                           | 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    TEQ=10                                 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Atrophy                              |                         2                                3               |             
      Degeneration, Cystic                 | 1        2                       2        2     1     3  4  2     2      |             
      Hyperplasia                          | 4  2     3  2        2  2  2  2        3  4     3  2        2     3     2|             
      Hypertrophy                          | 3  2  1  3  2     1     2  2  2  3     1  1  2  3  3  4     3     3  2  2|             
      Mineralization                       |                                                          3               |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |    2     2              3     1           2                       1     1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  1        3     2     2        2        2  2  2           2            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Vacuolization Cytoplasmic            |                                                       1                  |             
      Pars Distalis, Hyperplasia           | 3  2     2        2     3  2                          2           2  2  2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2        3        3     3     3  2        2        2                    3|             
      Follicular Cell, Hypertrophy         |                   1  1           2        1                 1     1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  2  1  1  1     1  1  1  1  2  2        1  1  1  2  1  2        2  1   |             
      Duct, Cyst                           | 3  3  2  3  2  3  3  1  2  3  2        3  1  3     3  1  3  4  1  2  3   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |    4     4  4  4     4  4  4  4  4     3  4  4  4  4  4  4  4     4  3  4|             
      Cyst                                 |    3     3              2                       2  3        2        2   |             
      Fibrosis                             |                                                             3            |             
      Inflammation, Chronic Active         |                                                 2                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|             
                                           | 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    TEQ=10                                 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                               +                                      +   |             
      Cyst                                 |                               2                                      2   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Chronic Active         |                                                          3               |             
      Inflammation, Suppurative            |    2  2                                                              2   |             
      Metaplasia, Squamous                 | 1  3  4     2     3  2  2  2  4  3           3  1  1  1              3  2|             
      Ulcer                                |       2                                                                  |             
      Endometrium, Hyperplasia, Cystic     | 2        3  2     3  3  3  2     2     2  2  1  2        2        3     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  3  2  3  2  2  4        2  3  4  3  2           4  2  3  3  3  2  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +                                                |             
      Mediastinal, Ectasia                 |                         2                                                |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Plasma Cell             | 2  3     2  1     2     3  2  2  2  2  2  3     3  2        2     2     2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  1  2  2     1  2  2  1  1  1  4  2  1     1     3  2  1  1  1  1  3|             
      Pigmentation                         | 1  2  1  1  1     1     2  1  2  2  1  1  2  2  2  1     1  1  1  1  1  1|             
      Lymphoid Follicle, Atrophy           |                3                                                         |             
      Red Pulp, Atrophy                    |                2                                                         |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      Atrophy                              | 2  3  3  3  3  2  3  3  4  3  3  3  2  2     2  3  4  3  4  3        4  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|             
                                           | 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    TEQ=10                                 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Cyst                                 |    3           3                          2                              |             
      Hyperplasia                          |       1                 1                 2                    1         |             
      Inflammation, Granulomatous          |                                                 1                        |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                           X        X                     |             
      Hair Follicle, Atrophy               |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                           1                              |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2  2  2  2     2  2  2  1  2  1  1  2  1  1  2  2  1  2  2  2  2  3  2|             
      Inflammation                         |                                                                      2   |             
      Alveolar Epithelium, Hyperplasia     |       1  1  1           2        1     1        1  1  1     1            |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2  2              1     2  1  2                          2        1  2  2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|             
                                           | 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    TERT.MIX                               | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    TEQ=10                                 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lens, Degeneration                   |                                                             4            |             
      Retina, Atrophy                      |                                                             4            |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1        1     1           1     1              1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |          2                                1           3                  |             
      Cyst                                 |                                                       2                  |             
      Inflammation, Chronic Active         |                                                       4                  |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1     1  1     1     1|             
      Nephropathy                          | 1  1  1  1  1  1  1     3  1  2  1  1     2  1  2  1     1  1        1  1|             
      Pelvis, Inflammation                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                   2                             1     3                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 2| 2|                                                                 |            |
                                           | 6| 9| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    TERT.MIX                               | 8| 9| 9|                                                                 |      L     |
    TEQ=10                                 | 9| 0| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     | X                                                                        |     14     |
      Basophilic Focus, Multiple           |       X                                                                  |     12     |
      Cholangiofibrosis                    |                                                                          |      2  1.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Eosinophilic Focus, Multiple         |                                                                          |      7     |
      Fatty Change, Diffuse                |                                                                          |      5  1.0|
      Fatty Change, Focal                  |                                                                          |      4  1.5|
      Hematopoietic Cell Proliferation     | 1     1                                                                  |     18  1.1|
      Hyperplasia, Nodular                 |                                                                          |      1     |
      Inflammation                         | 1  1  1                                                                  |     50  1.1|
      Mixed Cell Focus                     |                                                                          |      5     |
      Mixed Cell Focus, Multiple           |    X  X                                                                  |     27     |
      Necrosis                             | 2                                                                        |      1  2.0|
      Pigmentation                         | 1  1  2                                                                  |     35  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 2| 2|                                                                 |            |
                                           | 6| 9| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    TERT.MIX                               | 8| 9| 9|                                                                 |      L     |
    TEQ=10                                 | 9| 0| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Toxic Hepatopathy                    |                                                                          |      5  1.0|
      Bile Duct, Cyst                      |                                                                          |      3  2.7|
      Bile Duct, Fibrosis                  |                                                                          |      2  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      3  1.3|
      Centrilobular, Degeneration          |                                                                          |      2  2.0|
      Hepatocyte, Hypertrophy              |                                                                          |     27  1.1|
      Hepatocyte, Multinucleated           | 1     1                                                                  |     12  1.0|
      Oval Cell, Hyperplasia               |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +     +                                                                  |  18        |
      Gingival, Hyperplasia, Squamous      | 2     2                                                                  |     17  1.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      2  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      6  2.2|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +     +                                                                  |  23        |
      Peridontal Tissue, Inflammation      | 2     2                                                                  |     21  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 2| 2|                                                                 |            |
                                           | 6| 9| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    TERT.MIX                               | 8| 9| 9|                                                                 |      L     |
    TEQ=10                                 | 9| 0| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |    1  1                                                                  |     26  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |       2                                                                  |     20  1.6|
      Atrophy                              |                                                                          |      3  2.3|
      Degeneration, Cystic                 |       2                                                                  |     15  2.3|
      Hyperplasia                          |    3                                                                     |     26  2.4|
      Hypertrophy                          | 2  2  3                                                                  |     45  2.2|
      Mineralization                       |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |     13  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          | 1                                                                        |     21  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Cytoplasmic Alteration               |                                                                          |      3  1.3|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |    2  3                                                                  |     19  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  |    2  2                                                                  |     24  2.3|
      Follicular Cell, Hypertrophy         |                                                                          |     13  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 2| 2|                                                                 |            |
                                           | 6| 9| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    TERT.MIX                               | 8| 9| 9|                                                                 |      L     |
    TEQ=10                                 | 9| 0| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 2  2  2                                                                  |     40  1.7|
      Duct, Cyst                           | 2  2  3                                                                  |     41  2.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
      Atrophy                              | 4  4  4                                                                  |     44  4.0|
      Cyst                                 | 2     2                                                                  |     16  2.4|
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   2        |
      Cyst                                 |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenomyosis                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      5  2.2|
      Metaplasia, Squamous                 | 1  2                                                                     |     32  2.2|
      Ulcer                                |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |    2                                                                     |     35  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          |       3                                                                  |     36  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
      Mediastinal, Ectasia                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |    2  2                                                                  |     42  2.1|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 2| 2|                                                                 |            |
                                           | 6| 9| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    TERT.MIX                               | 8| 9| 9|                                                                 |      L     |
    TEQ=10                                 | 9| 0| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 3  1  2                                                                  |     48  1.5|
      Pigmentation                         | 1  2  1                                                                  |     50  1.3|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  3.0|
      Red Pulp, Atrophy                    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M                                                                  |  48        |
      Atrophy                              |    4                                                                     |     43  2.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      3  2.7|
      Hyperplasia                          |                                                                          |      7  1.6|
      Inflammation, Granulomatous          |                                                                          |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Hair Follicle, Atrophy               |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      4  1.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 2| 2|                                                                 |            |
                                           | 6| 9| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    TERT.MIX                               | 8| 9| 9|                                                                 |      L     |
    TEQ=10                                 | 9| 0| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 3  2  2                                                                  |     50  1.9|
      Inflammation                         |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |     25  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |       2                                                                  |     20  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      2  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Lens, Degeneration                   |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     11  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      5  1.8|
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 2| 2|                                                                 |            |
                                           | 6| 9| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    TERT.MIX                               | 8| 9| 9|                                                                 |      L     |
    TEQ=10                                 | 9| 0| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Mineralization                       | 1  1                                                                     |     48  1.0|
      Nephropathy                          | 1  1  1                                                                  |     41  1.2|
      Pelvis, Inflammation                 |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|             
                                           | 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|             
    TEQ=22                                 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                X  X  X   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                   X        X                       X                     |             
      Basophilic Focus, Multiple           |             X        X           X                                       |             
      Cholangiofibrosis                    |       3                                                                  |             
      Clear Cell Focus                     |                            X                                             |             
      Eosinophilic Focus                   |                   X              X                    X                  |             
      Eosinophilic Focus, Multiple         |    X  X                                   X                              |             
      Fatty Change, Diffuse                |    1                 1     1  1  1  1                    1  1            |             
      Fatty Change, Focal                  | 2                                                                        |             
      Hematopoietic Cell Proliferation     |    1     1        1  3                 1           1  1           1  1   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation                         | 2     2  1  1  2        2  1     1  1  1  1  1        1  2  1  1     1  1|             
      Mixed Cell Focus                     |                                     X                                X   |             
      Mixed Cell Focus, Multiple           | X  X  X  X  X              X              X  X        X  X  X  X  X     X|             
      Necrosis                             |                      2  2        2     2     1                           |             
      Pigmentation                         | 2  1  1  1  1  1  1  1  2  1     2  3     1  1        1  1  1  1  1     1|             
      Toxic Hepatopathy                    |       1     1        1           1        1              1               |             
      Bile Duct, Cyst                      |                                              2              2            |             
      Bile Duct, Fibrosis                  |                                              1                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|             
                                           | 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|             
    TEQ=22                                 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Hyperplasia               |       1                                                  1               |             
      Centrilobular, Degeneration          |                                                 3                        |             
      Hepatocyte, Hypertrophy              |    2  1  1  1     1  2     1  2  1        1        1  2  1  1  2        1|             
      Hepatocyte, Multinucleated           |                      1  1           2        1                           |             
      Oval Cell, Hyperplasia               |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Necrosis                             |                                     3                                    |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +  +  +  +              +        +     +           +     +  +      |             
      Gingival, Hyperplasia, Squamous      |       1  2  1  1              1        1     1           1     1  2      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  2                       1           1   |             
      Acinus, Atrophy                      |                                  2                       2           2   |             
      Acinus, Hyperplasia                  |             2                                                            |             
      Acinus, Vacuolization Cytoplasmic    |                                                                1         |             
      Artery, Inflammation, Chronic Active |       2                                                        1         |             
      Duct, Cyst                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                         1                                                |             
      Hyperkeratosis                       |                3        2                                                |             
      Hyperplasia, Squamous                |          1     3        3                                                |             
      Inflammation                         |                         3                                                |             
      Mineralization                       |                                                    2        1        1   |             
      Ulcer                                |                2                                                         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                    1        1            |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +  +  +  +  +  +        +  +        +     +           +     +     +   |             
      Peridontal Tissue, Inflammation      |    1  1  1  1  1           1  1        1     1           1     1         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|             
                                           | 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|             
    TEQ=22                                 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1        1     1  1     1     1  2        1        1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1        2     2     1                                   2            |             
      Degeneration, Cystic                 |    2        2  1           1  2  2        3                 3  1        3|             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
      Hyperplasia                          |    2  2     3  2        3  3     2  2     4                 4  3  2      |             
      Hypertrophy                          | 4  2  3  4  3  3  3     1  2  2  3  2  4  2  2        1  2  3  3  2  1  3|             
      Necrosis                             |                                                                   2      |             
      Vacuolization Cytoplasmic            |       1  2              2                                1        2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2              4  2                       1                    2     1|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Vacuolization Cytoplasmic            |                      1                                                   |             
      Pars Distalis, Hyperplasia           | 2        3     2     2  3  3              3  2        2              2  3|             
      Pars Intermedia, Cyst                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3        4  2     2              3  1     2              3        2      |             
      Follicular Cell, Hypertrophy         |                      2                    1  2           1           2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|             
                                           | 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|             
    TEQ=22                                 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  3  1     1  1  1     1     1           2  1     1  2  2  1  1  2     1|             
      Duct, Cyst                           |    2  1  3  2  3  2  4  3  1  3  1  1  1     2        3  2  3  2  2     3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4  4  4  4  4     4  4  4  4  4  3  4     4  4  4  3  4  4  4   |             
      Cyst                                 |    2  2  2     3  2  2  1     2  2        2                              |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |    2              2        2     2                       2        2      |             
      Metaplasia, Squamous                 |    4  2  2        3  1     4  1  3           1     1  2        2  3  3  1|             
      Endometrium, Hyperplasia, Cystic     | 4     3  4  1  1  1  4     4        2     2  3     1  2     1  1  1  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  2  3  3     3  4        3  2     3  2     2  3  3        2     3  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +                                                      |             
      Lumbar, Ectasia                      |                   2                                                      |             
      Lumbar, Hemorrhage                   |                   2                                                      |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Plasma Cell             |    2  2  2  2     2  2  2  2     2        2  3        2     2  2  2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         4|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  1  2  1     2  3     1     1     2           3  2        1  1  1  2|             
      Pigmentation                         | 1  1  1  1  1  2  1     3  1  1  3  2  1  2  2  2  1  1  2  2  1  1  1  1|             
      Lymphoid Follicle, Atrophy           |                                                 2                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|             
                                           | 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|             
    TEQ=22                                 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Red Pulp, Atrophy                    |                                                             2            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Atrophy                              | 3  2  3  3  1  3  3     4  2  4  3  2  4  4  3           2  4  3  4     2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |             1     1     1        1        1              1     1         |             
      Inflammation, Granulomatous          |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                X         |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                     2                       2            |             
      Inflammation, Granulomatous          |                      2                                                   |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                 3                        |             
      Edema                                |                                           2     2                        |             
      Hemorrhage                           |                                                 2                        |             
      Infiltration Cellular, Histiocyte    | 1  1  2  2  2  1  2  1     2  2  2  1  1  2        2  1  2  2  1  2     2|             
      Inflammation                         |                               2                 2                        |             
      Metaplasia, Squamous                 |       3     1                                                            |             
      Alveolar Epithelium, Hyperplasia     |                1              2                       1                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|             
                                           | 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|             
    TEQ=22                                 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2  1  3  2  2     2        1     2  1     1              2  2  1  1     2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       2                 2                                                |             
      Goblet Cell, Hyperplasia             |       2                                      2                           |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                +                                                         |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                            2                             2               |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1                                                           1     2   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                  2                    2           1      |             
      Casts Protein                        |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                            1                                             |             
      Mineralization                       | 1     1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Nephropathy                          | 1  1  2  1  1  1  1  1  2  1  1  1  2     1  1           1     2        1|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                                                                          |             
      Renal Tubule, Necrosis               |                                                                         2|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|             
                                           | 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|             
    TEQ=22                                 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Inflammation                         |                   1                                                      |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|             
                             DAY ON TEST   | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|             
                                           | 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    TEQ=22                                 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                2         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                             X                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                   X  X  X  X  X                             X           X|             
      Basophilic Focus, Multiple           |                                                                          |             
      Cholangiofibrosis                    |          2                 1                                             |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                X                                                  X      |             
      Eosinophilic Focus, Multiple         |             X                                                            |             
      Fatty Change, Diffuse                |                      1  1           1  1        1                        |             
      Fatty Change, Focal                  |             1                          2  2           1     1           2|             
      Hematopoietic Cell Proliferation     | 1     1     1  1     1                       1  1        1  1            |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Hyperplasia, Nodular                 |                X                 X  X                                    |             
      Inflammation                         | 1  1  1  1  2  1  1  1  1  1  1  1  2  1  1     1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     |                                     X           X                        |             
      Mixed Cell Focus, Multiple           | X        X  X  X     X     X  X  X     X  X  X           X  X     X      |             
      Necrosis                             |    3  3                                                        2        3|             
      Pigmentation                         | 1  1     1  2     1  1  1  2  1  1  1  2  1  2  1  1  1     1  1        1|             
      Toxic Hepatopathy                    |          1           1  1  1        1  1  1                       1      |             
      Bile Duct, Cyst                      |       3                                                                  |             
      Bile Duct, Fibrosis                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|             
                             DAY ON TEST   | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|             
                                           | 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    TEQ=22                                 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Hyperplasia               |                                        2                    1     2      |             
      Centrilobular, Degeneration          |                                                                          |             
      Hepatocyte, Hypertrophy              | 1  1  1  1  1  2     1  3  1        1     1  1        1        1  1     1|             
      Hepatocyte, Multinucleated           |             1                 1     1     1                       1     2|             
      Oval Cell, Hyperplasia               |          1                                                               |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Necrosis                             |                                                                          |             
      Fat, Necrosis                        |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +        +     +     +           +              +           +      |             
      Gingival, Hyperplasia, Squamous      | 4     1        1     1     1           1              4           1      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                                1           1      |             
      Acinus, Atrophy                      |                      2                                2           1      |             
      Acinus, Hyperplasia                  |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                            1        2                                    |             
      Artery, Inflammation, Chronic Active |             2                                                            |             
      Duct, Cyst                           | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      3   |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                      2   |             
      Inflammation                         |                                                                      2   |             
      Mineralization                       |                                                                         2|             
      Ulcer                                |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                           2                              |             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +        +     +     +  +  +     +  +     +  +  +  +  +     +      |             
      Peridontal Tissue, Inflammation      |       1        2     3     2  1        1  1     1  1  2           1      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|             
                             DAY ON TEST   | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|             
                                           | 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    TEQ=22                                 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1     1  1  1  1  1  2  1     1     1        1     1  1  1     1  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  1        1           1     2  2     1  3     1  2           1         |             
      Degeneration, Cystic                 |                2  3     2                 3           3     3  3  3      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |    3     4  3        3        2  4                       3  4  2  2      |             
      Hypertrophy                          | 2  2     2  2  2  3  2  3  2  2     1  2  4  2  2  2  4  2  4  3  4     2|             
      Necrosis                             |                   3                                                      |             
      Vacuolization Cytoplasmic            |                   1  1                    2                 1     1      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1           1     1  3           2  1                                    |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                                                                  |             
      Cyst                                 |                                           2                              |             
      Vacuolization Cytoplasmic            |                                                 1                        |             
      Pars Distalis, Hyperplasia           | 2     3  2  3  3  3              3        3     2  2        3     2     2|             
      Pars Intermedia, Cyst                |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2  1        3     1     3                       2  2  1  3      |             
      Follicular Cell, Hypertrophy         |    2        1  1              1                       1           1  3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|             
                             DAY ON TEST   | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|             
                                           | 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    TEQ=22                                 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1     1  1     2     1  1  1  1  1     1  1           1  1  2  1  1|             
      Duct, Cyst                           | 3  2  2  2  1  1  1  3  1  1  2  2  4  3  3  2  2  1  2  3     2  1  2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4        4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4        4|             
      Cyst                                 | 2  3  3  4              2  2        2        2        3                  |             
      Inflammation, Chronic Active         |                                        4                                 |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Chronic Active         |          3                                                               |             
      Inflammation, Suppurative            |             1              2                       1                     |             
      Metaplasia, Squamous                 | 2     3  3     1  4  2        1  2     3  2     3  2  2  2     3        2|             
      Endometrium, Hyperplasia, Cystic     | 2           3        1     1  1  2  3     2  2  1  2     2  3  2        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  3     3  4  2  2  3                    4  3  2  2     3  2  3     2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +                                                                     |             
      Lumbar, Ectasia                      |                                                                          |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                   2      |             
      Hyperplasia, Plasma Cell             |          2  3        1  2     2  2  2     2  3  2     3  2  2        2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  2  2  1  3  3  1  1  1  1  1  1  1  1  3  1  1  1  1  2  1  2      |             
      Pigmentation                         | 1  1  1  1  1  1  1  2  1  2  2  2  1  1  2  1  1  1  2  1  1  1  1  2  2|             
      Lymphoid Follicle, Atrophy           |                                                       2                 2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|             
                             DAY ON TEST   | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|             
                                           | 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    TEQ=22                                 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Red Pulp, Atrophy                    |                                                       2                 2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              | 4  4  4     3  3  4  4  3  4  2  4     3  4  4  3  4  4     4  2  3  3  4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                                                                        |             
      Hyperplasia                          |    1           1     1  1        1                                2      |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  2  1  2  2  1  2  2  2  2  2  2  1  1  1  1  1  2  2  2  2  1  1  2|             
      Inflammation                         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1        2     1              1              1     1                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|             
                             DAY ON TEST   | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|             
                                           | 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    TEQ=22                                 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       1     2     1  1  3  1     3  2  1  1     1     2  2  2  1        1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Goblet Cell, Hyperplasia             |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                  3                 2     1              1|             
      Casts Protein                        |                                                                          |             
      Inflammation, Chronic Active         |                                                    3                     |             
      Inflammation, Suppurative            |                1              1                                          |             
      Mineralization                       | 1  1  1     1  1  1  1  1  2  1  1  1     1  1  2        2  1  1  1  1  1|             
      Nephropathy                          |    2  1  2  1  1  1  1  2  2  1  1  1  1  1     1     3  1  2     1  1  1|             
      Pelvis, Dilatation                   |                                                    3                     |             
      Pelvis, Inflammation                 |                                                    3                     |             
      Renal Tubule, Necrosis               |                                                                          |             
      Transitional Epithelium, Hyperplasia |    2                             3        3     1  2        2           1|             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                    +                     |             
      Inflammation                         |                                                    2                     |             
      Transitional Epithelium, Hyperplasia |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|             
                             DAY ON TEST   | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|             
                                           | 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    TERT.MIX                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    TEQ=22                                 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Inflammation                         |    2                                               2                     |             
      Transitional Epithelium, Hyperplasia |                                                    2                     |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 9| 0| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=22                                 | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      5     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Basophilic Focus                     |                                                                          |     10     |
      Basophilic Focus, Multiple           |                                                                          |      3     |
      Cholangiofibrosis                    |                                                                          |      3  2.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      5     |
      Eosinophilic Focus, Multiple         | X     X                                                                  |      6     |
      Fatty Change, Diffuse                | 1                                                                        |     14  1.0|
      Fatty Change, Focal                  |                                                                          |      7  1.6|
      Hematopoietic Cell Proliferation     |       1                                                                  |     19  1.1|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia, Nodular                 |                                                                          |      3     |
      Inflammation                         | 1  2  1                                                                  |     45  1.2|
      Mixed Cell Focus                     |       X                                                                  |      5     |
      Mixed Cell Focus, Multiple           | X  X                                                                     |     30     |
      Necrosis                             |                                                                          |      9  2.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 9| 0| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=22                                 | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Pigmentation                         |    1                                                                     |     41  1.2|
      Toxic Hepatopathy                    |                                                                          |     14  1.0|
      Bile Duct, Cyst                      |                                                                          |      3  2.3|
      Bile Duct, Fibrosis                  |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      5  1.4|
      Centrilobular, Degeneration          |                                                                          |      1  3.0|
      Hepatocyte, Hypertrophy              | 1  1                                                                     |     34  1.2|
      Hepatocyte, Multinucleated           |                                                                          |     10  1.2|
      Oval Cell, Hyperplasia               |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Necrosis                             |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |  19        |
      Gingival, Hyperplasia, Squamous      |                                                                          |     18  1.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      6  1.3|
      Acinus, Atrophy                      |    1                                                                     |      7  1.7|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      3  1.3|
      Artery, Inflammation, Chronic Active |                                                                          |      3  1.7|
      Duct, Cyst                           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |                                                                          |      1  1.0|
      Hyperkeratosis                       |                                                                          |      2  2.5|
      Hyperplasia, Squamous                |                                                                          |      4  2.3|
      Inflammation                         |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      4  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 9| 0| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=22                                 | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Ulcer                                |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  27        |
      Peridontal Tissue, Inflammation      |                                                                          |     22  1.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |    1                                                                     |     31  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |    1                                                                     |     18  1.5|
      Degeneration, Cystic                 |       2                                                                  |     19  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          | 3                                                                        |     23  2.8|
      Hypertrophy                          | 2  2  2                                                                  |     47  2.4|
      Necrosis                             |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            | 2                                                                        |     11  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |     12  1.8|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  49        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 9| 0| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=22                                 | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |     24  2.5|
      Pars Intermedia, Cyst                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      C-Cell, Hyperplasia                  | 1  1                                                                     |     20  2.1|
      Follicular Cell, Hypertrophy         |                                                                          |     12  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         |    3  2                                                                  |     37  1.3|
      Duct, Cyst                           |    3                                                                     |     44  2.1|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4                                                                     |     43  4.0|
      Cyst                                 |    3                                                                     |     20  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenomyosis                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      9  1.8|
      Metaplasia, Squamous                 | 3                                                                        |     32  2.3|
      Endometrium, Hyperplasia, Cystic     | 2  3                                                                     |     34  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 9| 0| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=22                                 | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 2  2                                                                     |     34  2.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Lumbar, Ectasia                      |                                                                          |      1  2.0|
      Lumbar, Hemorrhage                   |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |    2                                                                     |     30  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 1  1  2                                                                  |     42  1.5|
      Pigmentation                         | 1  2  1                                                                  |     52  1.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      3  2.0|
      Red Pulp, Atrophy                    |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  50        |
      Atrophy                              | 4  3  4                                                                  |     45  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          |       1                                                                  |     14  1.1|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 9| 0| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=22                                 | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hydrocephalus                        |                                                                          |      2  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  3.0|
      Edema                                |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2  2                                                                     |     48  1.6|
      Inflammation                         |       2                                                                  |      3  2.0|
      Metaplasia, Squamous                 |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |     10  1.3|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 3  1                                                                     |     33  1.6|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      2  2.0|
      Goblet Cell, Hyperplasia             |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 9| 0| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=22                                 | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Eye                                     | +  +  +                                                                  |  53        |
      Retina, Atrophy                      |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      | 1                                                                        |      8  1.6|
      Casts Protein                        |       1                                                                  |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      3  1.0|
      Mineralization                       | 1  1  1                                                                  |     47  1.1|
      Nephropathy                          |    1                                                                     |     40  1.3|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Pelvis, Inflammation                 |                                                                          |      1  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia | 1                                                                        |      8  1.9|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         | 1                                                                        |      4  1.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|             
                                           | 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|             
    TEQ=46                                 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
      Artery, Inflammation, Chronic Active |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X     X        X                                                   |             
      Basophilic Focus, Multiple           |          X                 X                       X                     |             
      Cholangiofibrosis                    |                                              3           1               |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Degeneration, Cystic                 |                                                             1            |             
      Eosinophilic Focus                   |                                                             X     X      |             
      Eosinophilic Focus, Multiple         | X        X     X     X  X     X     X        X     X     X               |             
      Fatty Change, Diffuse                | 1  1        1  1     1     1  2  1     1     1  1  2        1  1  1  1   |             
      Fatty Change, Focal                  |                                                                         1|             
      Hematopoietic Cell Proliferation     | 1              1           1                             1               |             
      Hyperplasia, Nodular                 |                         X                       X  X                 X   |             
      Inflammation                         | 1  1     1  1  1  1  1  2  1  2     1  2  1  2  2  1  1  2  2  2  1  2  1|             
      Karyomegaly                          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           |    X        X     X  X  X           X  X  X              X  X  X  X  X  X|             
      Necrosis                             |                                              2  2     1                  |             
      Pigmentation                         | 2  3  2  2  2  2  1  1  1  2  2  2  2  2     2  2  2  2  3  2  2  2  2   |             
      Toxic Hepatopathy                    | 1  2  1  1  2        1  2     1     1  1        3  2     2  2  2  2  2  1|             
      Bile Duct, Cyst                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|             
                                           | 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|             
    TEQ=46                                 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |    1                                                        2     1      |             
      Bile Duct, Hyperplasia               |    1  2                 2              1        3  1        1     1  1   |             
      Centrilobular, Degeneration          |                                  2                                       |             
      Hepatocyte, Hypertrophy              | 1  2  2  1  3  1     2  2  1  2  2  1     1  1  3  3     4  1  1  1  2  2|             
      Hepatocyte, Multinucleated           | 1  2  1  1  1  1     1  2  3  1     1  2     1  2  2  2  2  2  2  2  2   |             
      Oval Cell, Hyperplasia               |    2  2     1           2           1  1        4  1        2     1  1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +  +                                                     +            |             
      Artery, Inflammation, Chronic Active |    4                                                        3            |             
      Fat, Necrosis                        |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +     +  +  +           +  +     +  +  +        +     +        +  +|             
      Gingival, Hyperplasia, Squamous      |       2     2     2              1     2  2  2        2     1        2  1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       3                                2        3                        |             
      Inflammation, Granulomatous          |                2                                                         |             
      Acinus, Atrophy                      |       2                                2        3                        |             
      Acinus, Vacuolization Cytoplasmic    |    1                       1        1  1                          1      |             
      Artery, Inflammation, Chronic Active |    3  3                                                     2        3   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                            3                                             |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3                                                                     |             
      Diverticulum                         |                                                          X               |             
      Hyperkeratosis                       |                2                                         2               |             
      Hyperplasia, Squamous                |       2        2        1        1              1        3               |             
      Inflammation                         |                                                          3               |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                2                                                         |             
      Artery, Inflammation, Chronic Active |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            2                                             |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|             
                                           | 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|             
    TEQ=46                                 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Tooth                                   |       +  +  +     +     +     +     +  +  +  +        +     +        +  +|             
      Peridontal Tissue, Inflammation      |       2  1  2     1                 1  1  1  1        1     1        1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                            2                                             |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1     1  1        1  2        1  1     1  2        1  1     1     1|             
      Mineralization                       |                            2                                             |             
      Artery, Degeneration                 |                                        2                                 |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2  2                       1  2  2     1  1           2  2      |             
      Degeneration, Cystic                 |          2  2           3              2  2                    3     2  3|             
      Hyperplasia                          | 2  3     3           3        3     2  3  2                 3  3  3      |             
      Hypertrophy                          |    2     2  4  2  1  2  4  1  1     2  2  2  1  3  3  3  2  2  1  2  3  3|             
      Inflammation                         |                                                                          |             
      Vacuolization Cytoplasmic            |                      2                             2                     |             
      Capsule, Inflammation                |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2              2     1        1                          2  3     2   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2              3                                                      |             
      Cyst                                 |                                                                          |             
      Vacuolization Cytoplasmic            |                      1  2                                            1   |             
      Pars Distalis, Hyperplasia           |    3        3  4     2  3           2           2  2     3           1  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|             
                                           | 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|             
    TEQ=46                                 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       3  2                 2     1                                2      |             
      Follicular Cell, Hypertrophy         |    2     2  2                       1                 2  2     1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                   2                                                      |             
      Inflammation                         | 1     1           2  1  1     1     1  1  1              2  1  1  1  1   |             
      Duct, Cyst                           | 3  3  2     2     3  2  2           1  2  2  3  2  3     2  3  2  2  2  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4     4  4  4  4  4  4  4     4  4  4  4  4  3  4  4  4  4     4  4|             
      Cyst                                 |    2  3                    2  2                                   2      |             
      Inflammation, Chronic Active         |                                                       4                  |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                2                                                         |             
      Inflammation, Chronic Active         |                                                                      4   |             
      Inflammation, Suppurative            |             3  2              3                       2  1  2            |             
      Metaplasia, Squamous                 |    3        4           2  1  3  1  2     2  3  3     3     4     4  3  2|             
      Thrombosis                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    4  1        3        1  3     2  2  3  1              1     1        2|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  3  3  3  3     3  4  2     3  3  2  3     2  3  3  4  2  2     3  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|             
                                           | 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|             
    TEQ=46                                 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +        +                 +  +  +               |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                    2  2                  |             
      Mediastinal, Ectasia                 |                         2                                2               |             
      Mediastinal, Fibrosis                |                                                                          |             
      Mediastinal, Hemorrhage              |                                                          2               |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Popliteal, Hyperplasia, Plasma Cell  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |    1        2  2        3              2        2        3  2            |             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  1  2  2  2     2  3     1     1  1  1     2  2     3  1     1  1  2|             
      Pigmentation                         | 2  1  1  1  1  1  2  1  1  1  2  1  1     1  2  1  1  2     2  2  2  2  1|             
      Lymphoid Follicle, Atrophy           | 2     3                                                                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  4  4  3  4        4  4  4  4     3  4  4  2  4  4  4  4  4  4  2  4  4|             
      Ectopic Thyroid                      |                   4                                                      |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |          1                             1                       1         |             
      Inflammation, Granulomatous          | 4              2                                                         |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|             
                                           | 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|             
    TEQ=46                                 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Cyst Epithelial Inclusion            |                                        X                                 |             
      Inflammation, Suppurative            |                2                                                         |             
      Ulcer                                |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hydrocephalus                        |                                              2                           |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3                                                                        |             
      Edema                                | 3                                                                        |             
      Infiltration Cellular, Histiocyte    | 2  2     2     2  1  2  1  1  2     2  2  2  1  2  2  1  2  1  1  1  2  2|             
      Inflammation                         |                                                       3                  |             
      Metaplasia, Squamous                 |                2                                                     3   |             
      Mineralization                       |                            1                                             |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |    2     2  1  2     3        1     2  1  2  1  3  2     3  2  1  1  3  2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Goblet Cell, Hyperplasia             |                                                                          |             
      Goblet Cell, Septum, Hyperplasia     |                   2                                                      |             
      Nasolacrimal Duct, Inflammation      |                                                                   3      |             
      Respiratory Epithelium, Hyperplasia  |                                        2                                 |             
      Turbinate, Cyst                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|             
                                           | 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|             
    TEQ=46                                 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Casts Protein                        |                                                                          |             
      Cyst                                 |                   3                                                      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                            1                                             |             
      Mineralization                       |       1     1  1     1     3     1  1  1  1  1  1  1  1  1  1  1  1     1|             
      Nephropathy                          |    2  2  1  1  1  1  1  2     1     1  1  1  1  3  1  1  1  2  1  1  2  1|             
      Pelvis, Dilatation                   |                                                                      3   |             
      Pelvis, Inflammation                 |                                                                      3   |             
      Renal Tubule, Hyperplasia            |                                        2                    1            |             
      Transitional Epithelium, Hyperplasia |                   2     2  2                                         3   |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                      +   |             
      Metaplasia, Squamous                 |                                                                      2   |             
      Transitional Epithelium, Hyperplasia |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation                         |                                     1                                1   |             
      Metaplasia, Squamous                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|             
                                           | 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    TEQ=46                                 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                1                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X                                   X            |             
      Basophilic Focus, Multiple           |                X                                         X           X   |             
      Cholangiofibrosis                    |                                                       2                  |             
      Clear Cell Focus, Multiple           | X                                                                        |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |          X                                X                       X      |             
      Eosinophilic Focus, Multiple         |                X     X  X        X  X                                    |             
      Fatty Change, Diffuse                | 2     1  1  1  1        1  1     1           1     1  1  2  1     1  1  1|             
      Fatty Change, Focal                  |                                           2                              |             
      Hematopoietic Cell Proliferation     |                   1     1           1                             1      |             
      Hyperplasia, Nodular                 |       X  X                             X  X                 X            |             
      Inflammation                         | 1  1  1  1  1  1  2  1  1  2  1  1  1  2  1  2  1  2  2  2  1     1  1  1|             
      Karyomegaly                          |                                     3                                    |             
      Mixed Cell Focus                     |                                                                         X|             
      Mixed Cell Focus, Multiple           | X  X  X  X  X  X     X  X  X     X     X  X  X     X  X  X  X     X  X   |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 2  1  2  2  2  2  1  2  1  2     2  3  2  1  2     2  2  2  2     2  2  2|             
      Toxic Hepatopathy                    | 1     1  2  1        1     2     2  3  2  1  1     2  2  1  1     1     1|             
      Bile Duct, Cyst                      | 2                                      2  3                 2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|             
                                           | 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    TEQ=46                                 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |          1                                            2                  |             
      Bile Duct, Hyperplasia               |       1  2           1     1     1  2  2  1        1  3  2  1           1|             
      Centrilobular, Degeneration          |                                                                          |             
      Hepatocyte, Hypertrophy              | 1  1  1  1  2  1  1  2  1     1  1  3  1  1  1  1  1  1     1     1  2  1|             
      Hepatocyte, Multinucleated           |       1  2           1  1  1     1  1  1           2  1  1  1     2  1  1|             
      Oval Cell, Hyperplasia               |          2           1     1     1  2  1  1        1  2  2  1           1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                         +                             +                 +|             
      Artery, Inflammation, Chronic Active |                                                       4                  |             
      Fat, Necrosis                        |                                                                         3|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +  +     +           +  +     +     +     +     +  +  +  +  +     +   |             
      Gingival, Hyperplasia, Squamous      |    1        1           3  1     1     1     1     3  1  1  2  2     1   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            1                          1           1      |             
      Inflammation, Granulomatous          |                                                                          |             
      Acinus, Atrophy                      |                            1                          1                  |             
      Acinus, Vacuolization Cytoplasmic    |       1  1  1  1                 1     1  1        1  1                  |             
      Artery, Inflammation, Chronic Active | 2              3                                      2                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                         2|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Diverticulum                         |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |       1                    2                                             |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                         1                                         1      |             
      Ulcer                                |                                                                          |             
      Artery, Inflammation, Chronic Active |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         2                                         1      |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|             
                                           | 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    TEQ=46                                 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Tooth                                   |    +     +  +  +        +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peridontal Tissue, Inflammation      |    1     1  1  1        2  1     1  4  2  1  1  1  2  1  1  1     1  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cardiomyopathy                       |    1  1  1     1  1  1        1  1  1  1     1     1  2           1      |             
      Mineralization                       |                                                                          |             
      Artery, Degeneration                 |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1  2  1                          1        2  2  3           1   |             
      Degeneration, Cystic                 |    2  2  2     3     2  3  2     2     2           3  2  3  2     2  2   |             
      Hyperplasia                          |       3  2  3     1        3        3  2  3  2        3  1        3      |             
      Hypertrophy                          | 2  3  3  3  2  3     3  4  2     3  2  2  3  4     4  2  3  3     2  2  3|             
      Inflammation                         |                                                                      2   |             
      Vacuolization Cytoplasmic            |             1        2        2        1                                 |             
      Capsule, Inflammation                |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        1  2     2              1                 1              1   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2     2               |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                            1                                      2      |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           | 3        2              2  1     3     1  3        3              4      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|             
                                           | 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    TEQ=46                                 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      C-Cell, Hyperplasia                  |    2  2     3  3        2           2        3        3  3  2            |             
      Follicular Cell, Hypertrophy         |          2  1        2     1     2     1        1  2     2        2  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         | 2     1  1  2  2     2           1     1  1  2  3  2     1  2     1  1  1|             
      Duct, Cyst                           | 3  1  2  1  3  1     2  3           4  3  3  3     3  3           3  2  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4     4  3  4  4  4  4  4  4  4  4  4  4  4  3  4|             
      Cyst                                 |    2     3           2              3        2        2  3  2           2|             
      Inflammation, Chronic Active         |                            3                                             |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                     +        +                           |             
      Inflammation, Chronic Active         |                                     4        4                           |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                  2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                1     2              1        2  1     2              2   |             
      Metaplasia, Squamous                 | 2  1  2     2  1           2  1     3  2  1  4  2  2     3  2  2  2     2|             
      Thrombosis                           |                                                                      3   |             
      Ulcer                                |                                     3                                    |             
      Endometrium, Hyperplasia, Cystic     | 3  1  2  4  2  2     4     2  1  2     2  3     1  3  3  1  2     2  4  3|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3     3  3     4  4  3     3  4  4  2  2  3  3  2  3     3  4  2     3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|             
                                           | 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    TEQ=46                                 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +                    +                                +|             
      Lumbar, Hyperplasia, Plasma Cell     |                   3                                                      |             
      Mediastinal, Ectasia                 |                                                                         2|             
      Mediastinal, Fibrosis                |                                                                         2|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Popliteal, Hyperplasia, Plasma Cell  |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             3                                3                           |             
      Hemorrhage                           |                                                                1         |             
      Hyperplasia, Plasma Cell             | 3  2     2  2  2  2  2              4  3              2  2  2     2      |             
      Necrosis, Focal                      |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |       2                                                                  |             
      Pigmentation                         |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1     2  2  1  3  3  3  1  2  2  3  1  1  1  1  1  1  1  1     2     1|             
      Pigmentation                         | 1  1  2  1  1  2     1  1        1  1  2  1  2  1  2  2  2  1  1  1     1|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  4  4  4  4  4  2  4  4  4  4  4  4  4  4  4  2  4  3  4  4  2  3  4  4|             
      Ectopic Thyroid                      |                                                                          |             
      Hemorrhage                           |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                      1           1  1  1     1        1  1  1        1   |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|             
                                           | 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    TEQ=46                                 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Cyst Epithelial Inclusion            |                                     X        X                           |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                1                                                         |             
      Hydrocephalus                        |                2                                                         |             
      Mineralization                       |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |       2                                                                  |             
      Infiltration Cellular, Histiocyte    | 3  1  2  2  2  2  1  1  1  1     1  2  1  2  2  1  1  2  1  2     2  2  1|             
      Inflammation                         |                                                                          |             
      Metaplasia, Squamous                 |       3  1                                   2           2        2      |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                                               1                        |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2  1  1  3  3  2     1  1        1  2  1  1  1     1  3  2  3     2  2  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1                                                                  |             
      Goblet Cell, Hyperplasia             |                                                                          |             
      Goblet Cell, Septum, Hyperplasia     |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                               2              1                 2         |             
      Turbinate, Cyst                      |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|             
                                           | 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    TERT.MIX                               | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    TEQ=46                                 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1                                   1                    1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                            1                       2     2     3         |             
      Casts Protein                        |                   1                                                      |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                4         |             
      Inflammation, Suppurative            |                                              2                 2         |             
      Mineralization                       |    1  1  1  1  1  1  1  1  1  1  1  1     2  1     1  1     1  3  1  1  1|             
      Nephropathy                          | 1     2  2  1  2     1  1  1  1  1  2  2  1  1  1  1  2  2  1     2  1  1|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                                                    2                     |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                   1           2     2              3     1               |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        2                                 |             
      Inflammation                         |                               2        1           2  1  1               |             
      Metaplasia, Squamous                 |                               3                                          |             
      Transitional Epithelium, Hyperplasia |                               3        3           2                     |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 3|                                                                 |            |
                                           | 8| 0| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=46                                 | 3| 4| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Basophilic Focus                     |                                                                          |      5     |
      Basophilic Focus, Multiple           | X                                                                        |      7     |
      Cholangiofibrosis                    |       4                                                                  |      4  2.5|
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      5     |
      Eosinophilic Focus, Multiple         |                                                                          |     15     |
      Fatty Change, Diffuse                |    1  1                                                                  |     34  1.1|
      Fatty Change, Focal                  |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      8  1.0|
      Hyperplasia, Nodular                 | X  X                                                                     |     11     |
      Inflammation                         | 2  1  1                                                                  |     50  1.3|
      Karyomegaly                          |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Mixed Cell Focus, Multiple           | X     X                                                                  |     35     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 3|                                                                 |            |
                                           | 8| 0| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=46                                 | 3| 4| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Necrosis                             |                                                                          |      3  1.7|
      Pigmentation                         | 2  2  2                                                                  |     48  1.9|
      Toxic Hepatopathy                    | 2  1  2                                                                  |     38  1.6|
      Bile Duct, Cyst                      |                                                                          |      4  2.3|
      Bile Duct, Fibrosis                  |                                                                          |      5  1.4|
      Bile Duct, Hyperplasia               | 1  1  1                                                                  |     25  1.4|
      Centrilobular, Degeneration          |                                                                          |      1  2.0|
      Hepatocyte, Hypertrophy              | 2     1                                                                  |     46  1.5|
      Hepatocyte, Multinucleated           | 2  2  1                                                                  |     39  1.5|
      Oval Cell, Hyperplasia               | 1  1  1                                                                  |     26  1.4|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Artery, Inflammation, Chronic Active |                                                                          |      3  3.7|
      Fat, Necrosis                        |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +     +                                                                  |  29        |
      Gingival, Hyperplasia, Squamous      | 2     1                                                                  |     26  1.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |    1                                                                     |      7  1.7|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Acinus, Atrophy                      | 1  2                                                                     |      7  1.7|
      Acinus, Vacuolization Cytoplasmic    |       1                                                                  |     15  1.0|
      Artery, Inflammation, Chronic Active |       3                                                                  |      8  2.6|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  3.0|
      Diverticulum                         |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Hyperplasia, Squamous                |       2                                                                  |      9  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 3|                                                                 |            |
                                           | 8| 0| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=46                                 | 3| 4| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  1.0|
      Ulcer                                |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +  +                                                                  |  37        |
      Peridontal Tissue, Inflammation      | 1  1  2                                                                  |     34  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  52        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Cardiomyopathy                       |    1  1                                                                  |     30  1.1|
      Mineralization                       |                                                                          |      1  2.0|
      Artery, Degeneration                 |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |     17  1.6|
      Degeneration, Cystic                 | 1  3                                                                     |     25  2.3|
      Hyperplasia                          |    4  3                                                                  |     25  2.6|
      Hypertrophy                          | 2  3  2                                                                  |     46  2.5|
      Inflammation                         |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |       2                                                                  |      7  1.7|
      Capsule, Inflammation                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 3|                                                                 |            |
                                           | 8| 0| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=46                                 | 3| 4| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hyperplasia                          | 2                                                                        |     15  1.7|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      2  2.5|
      Cyst                                 |                                                                          |      2  1.5|
      Vacuolization Cytoplasmic            |                                                                          |      3  1.3|
      Pars Distalis, Hyperplasia           |                                                                          |     20  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      C-Cell, Hyperplasia                  | 1  2  3                                                                  |     18  2.3|
      Follicular Cell, Hypertrophy         |                                                                          |     18  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  51        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation                         | 1  1                                                                     |     33  1.3|
      Duct, Cyst                           | 2  2  3                                                                  |     39  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4  4                                                                  |     49  3.9|
      Cyst                                 |                                                                          |     14  2.3|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   2        |
      Inflammation, Chronic Active         |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 3|                                                                 |            |
                                           | 8| 0| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=46                                 | 3| 4| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenomyosis                          |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |     13  1.8|
      Metaplasia, Squamous                 | 4  4                                                                     |     35  2.4|
      Thrombosis                           |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 1                                                                        |     33  2.2|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 4                                                                        |     41  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   9        |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      3  2.3|
      Mediastinal, Ectasia                 | 2                                                                        |      4  2.0|
      Mediastinal, Fibrosis                |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Histiocytic| 2                                                                        |      1  2.0|
      Popliteal, Hyperplasia, Plasma Cell  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Plasma Cell             |       3                                                                  |     22  2.3|
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 3|                                                                 |            |
                                           | 8| 0| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=46                                 | 3| 4| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 3  1  1                                                                  |     44  1.6|
      Pigmentation                         | 1  2  2                                                                  |     47  1.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4  4                                                                  |     50  3.7|
      Ectopic Thyroid                      |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |    3                                                                     |      1  3.0|
      Hyperplasia                          |                                                                          |     12  1.0|
      Inflammation, Granulomatous          |       3                                                                  |      3  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Cyst Epithelial Inclusion            |                                                                          |      3     |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  1.0|
      Hydrocephalus                        |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 3|                                                                 |            |
                                           | 8| 0| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=46                                 | 3| 4| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  3.0|
      Edema                                |                                                                          |      2  2.5|
      Infiltration Cellular, Histiocyte    | 2  2  2                                                                  |     48  1.6|
      Inflammation                         |                                                                          |      1  3.0|
      Metaplasia, Squamous                 |       1                                                                  |      8  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 2  2  2                                                                  |     41  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  1.0|
      Goblet Cell, Hyperplasia             |    2                                                                     |      1  2.0|
      Goblet Cell, Septum, Hyperplasia     |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      4  1.8|
      Turbinate, Cyst                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Retina, Atrophy                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |    1                                                                     |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      4  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 3|                                                                 |            |
                                           | 8| 0| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    TERT.MIX                               | 9| 9| 9|                                                                 |      L     |
    TEQ=46                                 | 3| 4| 5|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Casts Protein                        |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      3  1.7|
      Mineralization                       | 1  1  1                                                                  |     42  1.1|
      Nephropathy                          | 1  1  2                                                                  |     47  1.3|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Pelvis, Inflammation                 |                                                                          |      2  2.5|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.5|
      Transitional Epithelium, Hyperplasia |       2                                                                  |     10  2.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation                         |       2                                                                  |      8  1.4|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|             
                                           | 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    TEQ=100                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                4         |             
      Serosa, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                       1     1                                 |             
      Basophilic Focus                     |                      X                 X     X                 X         |             
      Basophilic Focus, Multiple           |       X                                            X     X               |             
      Cholangiofibrosis                    |    1           3           2  2                    2  2        2         |             
      Degeneration, Cystic                 |                                                             1            |             
      Eosinophilic Focus, Multiple         | X     X  X        X  X                 X  X  X  X     X  X               |             
      Fatty Change, Diffuse                |    1     1  1  1     1     1  1  1  1  2     1  1  2  2        1     2   |             
      Fatty Change, Focal                  |                                                                         1|             
      Hematopoietic Cell Proliferation     | 1                 1  1     1                                   1         |             
      Hyperplasia, Nodular                 |    X     X  X  X     X     X  X     X  X     X     X  X  X  X  X     X   |             
      Inflammation                         | 2  2  1  2  2  1  1  1     2  1  1  2  2  2  1  2  2  1  1  3  1  1  1  1|             
      Mixed Cell Focus, Multiple           |       X  X  X     X              X     X     X  X  X  X  X           X  X|             
      Necrosis                             |                            2  2  2     2           3        2     2      |             
      Pigmentation                         | 2  2  2  2  2  2  1  2     2  2  1  2  3  2  2  3  3  3  2  2  2  3  2  2|             
      Toxic Hepatopathy                    |    2  1     3  4     3     4  4  2  4  3     3  2  4  3  3  4  4  2  3  2|             
      Bile Duct, Cyst                      |                2           2                                2        2   |             
      Bile Duct, Dilatation                |             3                                                            |             
      Bile Duct, Fibrosis                  |                                                                2         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|             
                                           | 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    TEQ=100                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Hyperplasia               |       1  1  2  2     1     2  2     2        2  1  2  2  1  4  2  3  1   |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Fibrosis              |                                                                          |             
      Hepatocyte, Hypertrophy              | 2  3  2  2  3  3  2  3     4  4  2  3  3  2  3  2  3  4  1  4  3  3  3  1|             
      Hepatocyte, Multinucleated           | 1  3  1  2  2  2  1  1     3  2  1  3  2  1  2  2  2  2  3  2  3  3  2  1|             
      Oval Cell, Hyperplasia               |          1  2  3     2     2  3     2  1     2  2  3  2  2  3  2  2  2   |             
      Portal, Fibrosis                     |                2     2                             2              2      |             
      Serosa, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                +     +        +                       +        +         |             
      Inflammation, Chronic Active         |                      3                                                   |             
      Necrosis                             |                                                                          |             
      Artery, Inflammation, Chronic Active |                4              3                       4        4         |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +     +  +  +  +     +        +        +  +  +     +     +     +  +  +  +|             
      Gingival, Hyperplasia, Squamous      | 1     1  1  2  1     1        2        2  1  2     1     3     1  2  1  1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2                 3              1           2     2     2     3      |             
      Acinus, Atrophy                      |    2        2        2              2           2           3  2  2      |             
      Acinus, Vacuolization Cytoplasmic    | 1  1     1  2  1           1  1     2  2  1     1  1     1     1     1   |             
      Artery, Inflammation, Chronic Active |                3                                   3  2     3  3  3      |             
      Duct, Dilatation                     |                               3                       3                  |             
      Duct, Inflammation, Chronic Active   |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                      2                                   1               |             
      Ulcer                                |                      2                                                   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                      2   |             
      Artery, Inflammation, Chronic Active |                                                                3  3      |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|             
                                           | 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    TEQ=100                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Tongue                                  |                                                                         +|             
      Infiltration Cellular                |                                                                         3|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +  +  +        +        +        +  +              +     +  +  +  +|             
      Peridontal Tissue, Inflammation      | 1     1  1  1        2        1        2  1              3     1  1  1  2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                               2                                         2|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1  1  2     1        1        1     1  1     1        1  1  1   |             
      Inflammation, Suppurative            |                                                    4                     |             
      Necrosis                             |                                                    3                     |             
      Thrombosis                           |                                                    3                     |             
      Artery, Degeneration                 |                                                             2            |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                          2                 2                     |             
      Atrophy                              |    3     2  2        2        2     2        3        4     4            |             
      Degeneration, Cystic                 |    2                 2                          3     3     3            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2           3        2           2  2              3     2     2  3      |             
      Hypertrophy                          | 2  4  2  2  2  3     2     3  1  1  2  2  2     4  2  3  1  3  2  2  3  2|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                              3     2                     |             
      Vacuolization Cytoplasmic            |          1  2              1     1                 1        2            |             
      Capsule, Inflammation                |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1           1                                      1   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|             
                                           | 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    TEQ=100                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Vacuolization Cytoplasmic            |       1                                                                  |             
      Pars Distalis, Hyperplasia           | 2        3        1        2        2  2        2     2        2  2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2     2  3     2     3           4        1                        |             
      Follicular Cell, Hypertrophy         | 2     2  2  2  2  2        1     3  1        3  1        1     1  2     3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1        1  1     1        1  1  2  1  1        1  1        1  1  1  1  1|             
      Duct, Cyst                           | 2  2  1  1  2  1  1  2     3  3  3  4  2  1  2  3  3  3  3  3  1  2     1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4     4  4  4  4  4     4  4  4  4     4  4  4  4  4  4  4  4         |             
      Cyst                                 |          2                                            2                  |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                          4               |             
      Artery, Inflammation, Chronic Active |                                              4                           |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                          +               |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                          4               |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                          2               |             
      Hemorrhage                           |                            2                                             |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Inflammation, Suppurative            |                            3                             2  4            |             
      Metaplasia, Squamous                 | 2           1  1  2  4        3  2  3        4     2  3  2  3  3         |             
      Necrosis                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|             
                                           | 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    TEQ=100                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Endometrium, Fibrosis                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2        2  4  2  1           4     1  1  1     4  1     3     2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  3  3  3  3  4  4  3  3  4  3  3  2  3  3  3  2  3  4  3  4  3  3   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +                 +                    +  +            |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                     1                       3            |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                   2                                      3               |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |             
      Pancreatic, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                   2           2     2  2  2     3     3  2     2  2  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                             2            |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  2  2     1  1  3  3     1        1           1  1  2     2  2  2  3   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                    2                     |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 1  1  1  1  1  1  1  1           1  1  3  2  2  1  1  1  1  1  1  1  1  1|             
      Lymphoid Follicle, Atrophy           |                               3  2                                       |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Atrophy                              | 3  4  4  4  4  4  2        4  4  4     4  4  4  4  4  4  4  4  4  4     3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|             
                                           | 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    TEQ=100                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     1                                                           1  1   |             
      Inflammation, Granulomatous          |                                                             2            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |             X                                                            |             
      Ulcer                                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                2         |             
      Gliosis                              |                                                                3         |             
      Necrosis                             |                                                    2           1     2   |             
      Artery, Degeneration                 |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                         1|             
      Infiltration Cellular, Histiocyte    | 1  2     2  2  2  1  1  2  2  1  1  2  1  2  2  2  2  1  1  1  1  2  1  1|             
      Inflammation                         |                                                                          |             
      Metaplasia, Squamous                 |                                        1     2  3  3           2         |             
      Alveolar Epithelium, Hyperplasia     |                            1                                             |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1  2     3  3  2  1  2     1  2     3  1  2  3  3  3  1  2  1  2  2  1   |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                         3                                                |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|             
                                           | 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    TEQ=100                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Turbinate, Respiratory Epithelium,   |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |          +                                                               |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Ciliary Body, Iris,|                                                                          |             
           Inflammation, Suppurative       |                                        2                                 |             
      Cornea, Inflammation, Suppurative    |                                        3                                 |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation                         |       1  1                             2        1                        |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |       2                                                                  |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |          1                                         3                     |             
      Mineralization                       | 1  1     1     1  1  1     1     1     1  2  1           2  1  1        1|             
      Nephropathy                          |    1  1  1  3  3  1  1     1  4  1  1  2  2  1  2  1  3  1  2  3  3  3  1|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |             2                                                            |             
      Transitional Epithelium, Hyperplasia |          2  2        3        3                                          |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                         +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |             3                 1                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|             
                             DAY ON TEST   | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|             
                                           | 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    TEQ=100                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |             1                 2                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|             
                             DAY ON TEST   | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|             
                                           | 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    TEQ=100                                | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                            3           2                                 |             
      Serosa, Inflammation                 |                                                                         3|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                            2                                             |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                      X                 X  X                    X         |             
      Basophilic Focus, Multiple           |    X           X                 X                    X     X            |             
      Cholangiofibrosis                    | 3  3        2        3                                   3        3  1   |             
      Degeneration, Cystic                 |                                                                      1   |             
      Eosinophilic Focus, Multiple         |       X     X                          X           X     X  X            |             
      Fatty Change, Diffuse                | 2     2  1  1  1     1  1  1        1  1     1  2  1  1  1  1     1  1   |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                1           1                          1                 2|             
      Hyperplasia, Nodular                 | X  X  X  X  X  X     X  X  X     X  X  X  X  X  X     X  X        X  X   |             
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1     2     2  1  1  1  2  1  2  1  1  1  1  1|             
      Mixed Cell Focus, Multiple           |                   X        X                       X     X               |             
      Necrosis                             | 3  3                                   3  2                       2     1|             
      Pigmentation                         | 2  2  3  3  3  2  2  2  2  2     2  2  3  2  2  2  2  2  2  3  3  2  3  2|             
      Toxic Hepatopathy                    | 3  3  3  4  3  4  2  4  4  3     3  3  3  3  1  4  2  3  3  2  3  4  4  3|             
      Bile Duct, Cyst                      | 2                                         2              1        3      |             
      Bile Duct, Dilatation                |                                                                          |             
      Bile Duct, Fibrosis                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|             
                             DAY ON TEST   | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|             
                                           | 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    TEQ=100                                | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Hyperplasia               | 2  1  1  3  1  1     2  3  2     3     2  3  1  2  1  1  2  2  2  3  3  1|             
      Centrilobular, Degeneration          |       2                                               2        2     2   |             
      Centrilobular, Fibrosis              |                                                                         1|             
      Hepatocyte, Hypertrophy              | 4  3  3  3  3  3  2  4  4  3     4  3  3  4  3  4  3  2  3  4  3  3  3  3|             
      Hepatocyte, Multinucleated           | 2  3  2  3  2  3  2  2  2  2     2  2  2  1  2  2  2  2  2  2  3  2  2  2|             
      Oval Cell, Hyperplasia               | 3  2  1  3  1  2     2  3  2     3     2  3  1  2  1  2  3  3  2  3  3  1|             
      Portal, Fibrosis                     | 2           1                                   1     2  2               |             
      Serosa, Fibrosis                     |                                                             2            |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +                                      +                    +|             
      Inflammation, Chronic Active         |                                                                         3|             
      Necrosis                             |                                                                         4|             
      Artery, Inflammation, Chronic Active |             3                                      4                     |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +        +  +  +  +              +  +  +     +  +        +     +   |             
      Gingival, Hyperplasia, Squamous      | 2  4  1        1  1  3  1              3  1  1     2  1              2   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          1           2  1  2              3  1                    1  2  1|             
      Acinus, Atrophy                      | 2        2  1  2     2     3           3  2  1              1     2     2|             
      Acinus, Vacuolization Cytoplasmic    | 2  1                 1  1  1        1  1     1  1  1     1     1  1      |             
      Artery, Inflammation, Chronic Active |    3        3     3        3           2  4        4                     |             
      Duct, Dilatation                     |                         3                 3                          3   |             
      Duct, Inflammation, Chronic Active   |                                           4                          3   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     3                                    |             
      Hyperplasia, Squamous                |                      3  2        2  4           2           2            |             
      Inflammation                         |                                                                         2|             
      Ulcer                                |                                                                         2|             
      Artery, Inflammation, Chronic Active |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|             
                             DAY ON TEST   | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|             
                                           | 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    TEQ=100                                | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Tongue                                  |                                                                          |             
      Infiltration Cellular                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +        +  +  +  +  +        +     +  +  +        +     +  +  +      |             
      Peridontal Tissue, Inflammation      | 1  3        1  1  1  2  1        4     1  1  1        1     4  4  4      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  1  1  1  1     1        1     1     1  1  1  1  2     2  1   |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Artery, Degeneration                 |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1     2                          1  2        2                  |             
      Atrophy                              | 3           2  4     3  2  2                          2  4               |             
      Degeneration, Cystic                 |                2  1  3              2  2        2  2     2        2      |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hyperplasia                          | 2     2  4           3  2           2     3        3        4     2  2   |             
      Hypertrophy                          |    2  1  1  2  4  3     1  3     1  2  4     3  3  2  3  4  1  1  3  1   |             
      Mineralization                       |                      3                                                   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |       1        2     2                 2  1           2        1     2   |             
      Capsule, Inflammation                |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                                  2     2  1     1      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|             
                             DAY ON TEST   | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|             
                                           | 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    TEQ=100                                | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                3  2      |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           | 3        2           2  3        1        2        2              2  2   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2                    1              1              2              2  1   |             
      Follicular Cell, Hypertrophy         |    3           2  3  2  1                                            1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1        1  1  1  2  1  1  1           2                       1     1  1|             
      Duct, Cyst                           | 3     2     1  3  3     3  3        3  2  2  2  3  3     2  3  2  3  3  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  4  4  4  4  4  3  4  4     4  4  4  4     4     4  4  4  4     4  4|             
      Cyst                                 | 2              2                    2           3                 3      |             
      Hemorrhage                           |          2                                                               |             
      Inflammation, Chronic Active         |    3     3                       4                                4      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |    +                                                        +  +  +      |             
      Cyst                                 |    2                                                                     |             
      Inflammation, Chronic Active         |                                                             4  4  4      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                   4     3|             
      Inflammation, Suppurative            | 3        4                       3                                       |             
      Metaplasia, Squamous                 | 4     3  3  2     1  1  3  2     3                    2  3  1  3  1  1  4|             
      Necrosis                             |                                                                         4|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|             
                             DAY ON TEST   | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|             
                                           | 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    TEQ=100                                | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Endometrium, Fibrosis                |                                                    2                     |             
      Endometrium, Hyperplasia, Cystic     |    1  1     3     4  3     3     3  1  1                             1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3     3  3  3     3  3  3  3  3  3  3  3  3     3  3  3  2  2  3  3  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +           +     +           +     +  +         |             
      Lumbar, Hyperplasia, Lymphoid        |                                                             2            |             
      Mediastinal, Ectasia                 |                                                       2        2         |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                             2  3         |             
      Pancreatic, Hyperplasia, Histiocytic |                                           2                              |             
      Pancreatic, Hyperplasia              |                         4                                                |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |    2  2  3  2     3  2     3                       1     2  3  3  3  2  3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hemorrhage                           |          2                                                               |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia                          |                                              4                           |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  1  1  2  1  1  1  2  2     1     2  1  1  1  2  1  2  2  2  1  2  4|             
      Hemorrhage                           |                                     2                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                     3                                    |             
      Pigmentation                         | 1  1  1  1  1  1  1     1  1     1     1  1  2  2     1  1  1  1  1  1  1|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  3  4  4  4  4  4  4  4  3  4     4  4  4  4  4  4  4  4  4  4  4  4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|             
                             DAY ON TEST   | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|             
                                           | 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    TEQ=100                                | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                            1  1  1                     |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                X                                                         |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      2     2                                             |             
      Gliosis                              |                                                                          |             
      Necrosis                             |                                                                          |             
      Artery, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  1  2  2  1  2  1  2  2  1     1  1  1  1  2  1  1  1  2  1  1  1  2   |             
      Inflammation                         |                                  3                                       |             
      Metaplasia, Squamous                 |    1                                2              2  1              1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       2  1     2     3  2  2     1  1  2  1  3     2  1  2     2  1  3   |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2                                                                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|             
                             DAY ON TEST   | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|             
                                           | 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    TEQ=100                                | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Turbinate, Respiratory Epithelium,   |                                                                          |             
           Hyperplasia                     |                         2                                                |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Ciliary Body, Iris,|                                                                          |             
           Inflammation, Suppurative       |                                                                          |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Retina, Atrophy                      |       2                                            2                     |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         4|             
      Inflammation                         | 1                                                     1                  |             
      Necrosis                             |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Developmental Malformation           |          X                                                               |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |    4                 3                                      3            |             
      Mineralization                       | 1  2  2        1  2              1  1  1  1  1  1  1     2  1  1  1  1  1|             
      Nephropathy                          | 3     1  1  2  3  2  4  3  3     2  2  2  3  1  2  2  2  3  1  3  2  3  3|             
      Pelvis, Dilatation                   |    2                                                                     |             
      Pelvis, Inflammation                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                  3                             2         |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      2                                                   |             
      Inflammation                         |                      3           1                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|             
                             DAY ON TEST   | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|             
                                           | 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    TERT.MIX                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    TEQ=100                                | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |                      1                                                   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 6| 1| 9|                                                                 |            |
                                           | 6| 5| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    TEQ=100                                | 8| 9| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
      Artery, Inflammation, Chronic Active |                                                                          |      3  3.0|
      Serosa, Inflammation                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  51        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
      Serosa, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  51        |
      Angiectasis                          |                                                                          |      3  1.0|
      Basophilic Focus                     |                                                                          |      8     |
      Basophilic Focus, Multiple           |                                                                          |      8     |
      Cholangiofibrosis                    | 1  3  3                                                                  |     17  2.3|
      Degeneration, Cystic                 |                                                                          |      2  1.0|
      Eosinophilic Focus, Multiple         | X     X                                                                  |     19     |
      Fatty Change, Diffuse                | 2  2                                                                     |     36  1.3|
      Fatty Change, Focal                  |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      9  1.1|
      Hyperplasia, Nodular                 | X  X  X                                                                  |     38     |
      Inflammation                         | 1  2  1                                                                  |     50  1.3|
      Mixed Cell Focus, Multiple           |                                                                          |     17     |
      Necrosis                             | 1  3                                                                     |     15  2.2|
      Pigmentation                         | 2  3  2                                                                  |     51  2.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 6| 1| 9|                                                                 |            |
                                           | 6| 5| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    TEQ=100                                | 8| 9| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Toxic Hepatopathy                    | 4  4  3                                                                  |     47  3.1|
      Bile Duct, Cyst                      |    2                                                                     |      9  2.0|
      Bile Duct, Dilatation                |                                                                          |      1  3.0|
      Bile Duct, Fibrosis                  |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  2  1                                                                  |     42  1.9|
      Centrilobular, Degeneration          |    3  2                                                                  |      6  2.2|
      Centrilobular, Fibrosis              |                                                                          |      1  1.0|
      Hepatocyte, Hypertrophy              | 3  3                                                                     |     50  3.0|
      Hepatocyte, Multinucleated           | 2  2  3                                                                  |     51  2.1|
      Oval Cell, Hyperplasia               | 3  3  1                                                                  |     42  2.2|
      Portal, Fibrosis                     | 2  3                                                                     |     11  1.9|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic Active |                                                                          |      6  3.7|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |  31        |
      Gingival, Hyperplasia, Squamous      |    2                                                                     |     30  1.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  51        |
      Inflammation, Chronic Active         |                                                                          |     16  1.8|
      Acinus, Atrophy                      |                                                                          |     20  2.0|
      Acinus, Vacuolization Cytoplasmic    | 1  1                                                                     |     30  1.1|
      Artery, Inflammation, Chronic Active |    2                                                                     |     14  2.9|
      Duct, Dilatation                     |                                                                          |      5  3.0|
      Duct, Inflammation, Chronic Active   |                                                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  52        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      6  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 6| 1| 9|                                                                 |            |
                                           | 6| 5| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    TEQ=100                                | 8| 9| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         |                                                                          |      3  1.7|
      Ulcer                                |                                                                          |      2  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  52        |
      Mineralization                       |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Infiltration Cellular                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +  +                                                                  |  30        |
      Peridontal Tissue, Inflammation      |    2  1                                                                  |     30  1.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       | 1  1  1                                                                  |     32  1.1|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Artery, Degeneration                 |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  51        |
      Angiectasis                          |                                                                          |      8  1.6|
      Atrophy                              |    2                                                                     |     18  2.7|
      Degeneration, Cystic                 | 1  2                                                                     |     16  2.1|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 6| 1| 9|                                                                 |            |
                                           | 6| 5| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    TEQ=100                                | 8| 9| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hyperplasia                          | 3                                                                        |     21  2.5|
      Hypertrophy                          | 2  4  1                                                                  |     45  2.3|
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            | 2                                                                        |     15  1.5|
      Capsule, Inflammation                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  51        |
      Hyperplasia                          | 2                                                                        |      9  1.6|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      3  2.3|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |     19  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      C-Cell, Hyperplasia                  | 2                                                                        |     14  2.0|
      Follicular Cell, Hypertrophy         | 3                                                                        |     23  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  50        |
      Inflammation                         | 1                                                                        |     29  1.1|
      Duct, Cyst                           |    1  2                                                                  |     44  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  51        |
      Atrophy                              |    4                                                                     |     40  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 6| 1| 9|                                                                 |            |
                                           | 6| 5| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    TEQ=100                                | 8| 9| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Cyst                                 |                                                                          |      7  2.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      5  3.6|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   5        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      4  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  51        |
      Adenomyosis                          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
      Inflammation, Suppurative            |                                                                          |      6  3.2|
      Metaplasia, Squamous                 |                                                                          |     30  2.4|
      Necrosis                             |                                                                          |      1  4.0|
      Endometrium, Fibrosis                |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     23  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 3  3                                                                     |     48  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |  11        |
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      2  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      2  2.0|
      Mediastinal, Hyperplasia, Histiocytic|       2                                                                  |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.5|
      Mediastinal, Hyperplasia, Plasma Cell|       2                                                                  |      3  2.3|
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia              |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 6| 1| 9|                                                                 |            |
                                           | 6| 5| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    TEQ=100                                | 8| 9| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Hyperplasia, Plasma Cell             | 3     2                                                                  |     27  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  51        |
      Hematopoietic Cell Proliferation     | 1  1  1                                                                  |     42  1.6|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         | 1  1  1                                                                  |     46  1.1|
      Lymphoid Follicle, Atrophy           |    2                                                                     |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  50        |
      Atrophy                              | 4  4  4                                                                  |     48  3.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  52        |
      Hyperplasia                          | 1                                                                        |      9  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Cyst Epithelial Inclusion            |    X                                                                     |      3     |
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 6| 1| 9|                                                                 |            |
                                           | 6| 5| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    TEQ=100                                | 8| 9| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      3  2.0|
      Gliosis                              |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      3  1.7|
      Artery, Degeneration                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Cyst                                 |       3                                                                  |      1  3.0|
      Edema                                |       2                                                                  |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    | 2  1  1                                                                  |     50  1.4|
      Inflammation                         |       3                                                                  |      2  3.0|
      Metaplasia, Squamous                 |       3                                                                  |     11  1.9|
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |      2  1.5|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 2  2                                                                     |     40  1.9|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  2.0|
      Turbinate, Respiratory Epithelium,   |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                   Date: 09/29/03    
Route: GAVAGE                                                                                                     Time: 12:07:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 3|                                                                 |            |
                             DAY ON TEST   | 6| 1| 9|                                                                 |            |
                                           | 6| 5| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    TERT.MIX                               | 8| 8| 9|                                                                 |      L     |
    TEQ=100                                | 8| 9| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Anterior Chamber, Ciliary Body, Iris,|                                                                          |            |
           Inflammation, Suppurative       |                                                                          |      1  2.0|
      Cornea, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Retina, Atrophy                      | 2                                                                        |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation                         |       1                                                                  |      7  1.1|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  51        |
      Calculus Micro Observation Only      |                                                                          |      1  2.0|
      Developmental Malformation           |                                                                          |      1     |
      Fibrosis                             | 2                                                                        |      1  2.0|
      Inflammation, Suppurative            |    3                                                                     |      6  2.8|
      Mineralization                       | 1     1                                                                  |     35  1.2|
      Nephropathy                          | 2  4  1                                                                  |     49  2.1|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Pelvis, Inflammation                 |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia | 2  3                                                                     |      8  2.5|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation                         |    2                                                                     |      5  2.0|
      Transitional Epithelium, Hyperplasia |    3                                                                     |      4  1.8|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.