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TDMS Study 96007-04 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                    TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 DATE: 09/29/03       
EXPERIMENT: 96007 TEST: 04                                                                                     TIME: 12:11:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: 96007B       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFDIOXINMIX    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#4/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                    TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 DATE: 09/29/03       
EXPERIMENT: 96007 TEST: 04                                                                                     TIME: 12:11:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: 96007B       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFDIOXINMIX    
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF  TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Degeneration Cystic                                                                          
                                       Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
                                       Vacuolization Cytoplasmic                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
Blood Vessel: Aorta                    Mineralization                                                                               
Bone Marrow                            Hyperplasia                                                                                  
Brain                                  Edema                                                                                        
                                       Necrosis                                                                                     
Clitoral Gland                         Inflammation                                                                                 
Clitoral Gland: Duct                   Cyst                                                                                         
Heart                                  Cardiomyopathy                                                                               
Intestine Large, Rectum                Parasite Metazoan                                                                            
Intestine Large, Rectum: Artery        Inflammation Chronic                                                                         
Kidney                                 Calculus Micro Observation Only                                                              
                                       Inflammation                                                                                 
                                       Mineralization                                                                               
                                       Nephropathy                                                                                  
Kidney: Transitional Epithelium        Hyperplasia                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Cholangiofibrosis                                                                            
                                       Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Hematopoietic Cell Proliferation                                                             
                                       Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Mixed Cell Focus                                                                             
                                       Necrosis                                                                                     
                                       Pigmentation                                                                                 
                                       Toxic Hepatopathy                                                                            
Liver: Bile Duct                       Cyst                                                                                         
                                       Hyperplasia                                                                                  
Liver: Centrilobular                   Degeneration                                                                                 
Liver: Hepatocyte                      Hypertrophy                                                                                  
                                       Multinucleated                                                                               
Liver: Oval Cell                       Hyperplasia                                                                                  
Liver: Portal                          Fibrosis                                                                                     
Lung                                   Infiltration Cellular Histiocyte                                                             
                                       Metaplasia                                                                                   
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
                                       Metaplasia Bronchiolar                                                                       
Lymph Node, Mandibular                 Hyperplasia                                                                                  
Lymph Node, Mesenteric                 Hyperplasia                                                                                  
Lymph Node: Mediastinal                Ectasia                                                                                      
                                       Hyperplasia                                                                                  
                                       Hyperplasia Lymphoid                                                                         
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                    TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 DATE: 09/29/03       
EXPERIMENT: 96007 TEST: 04                                                                                     TIME: 12:11:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: 96007B       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFDIOXINMIX    
Lymph Node: Pancreatic                 Hyperplasia                                                                                  
Mammary Gland                          Hyperplasia                                                                                  
Mesentery                              Inflammation Chronic                                                                         
Mesentery: Artery                      Inflammation Chronic                                                                         
Nose: Respiratory Epithelium           Hyperplasia                                                                                  
Oral Mucosa: Gingival                  Hyperplasia                                                                                  
Ovary                                  Atrophy                                                                                      
                                       Cyst                                                                                         
                                       Inflammation Chronic                                                                         
Oviduct                                Inflammation Chronic                                                                         
Pancreas                               Inflammation Chronic                                                                         
Pancreas: Acinus                       Atrophy                                                                                      
                                       Vacuolization Cytoplasmic                                                                    
Pancreas: Artery                       Inflammation Chronic                                                                         
Pancreas: Duct                         Dilatation                                                                                   
                                       Inflammation Chronic                                                                         
Pituitary Gland                        Angiectasis                                                                                  
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
Skin                                   Cyst Epithelial Inclusion                                                                    
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Stomach, Forestomach                   Hyperplasia                                                                                  
Stomach, Forestomach: Artery           Inflammation Chronic                                                                         
Stomach, Glandular: Artery             Inflammation Chronic                                                                         
Thymus                                 Atrophy                                                                                      
                                       Cyst                                                                                         
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Tooth: Peridontal Tissue               Inflammation                                                                                 
Urinary Bladder                        Inflammation                                                                                 
Urinary Bladder: Transitional Epithelium                                                                                            
                                       Hyperplasia                                                                                  
Uterus                                 Inflammation Chronic                                                                         
                                       Metaplasia                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        15/52 (29%)      20/53 (38%)      18/53 (34%)      17/53 (32%)      8/51 (16%)                       | 
|POLY-3 RATE (b)    |        15/37.13         20/42.36         18/42.67         17/41.89         8/35.64                          | 
|POLY-3 PERCENT (g) |        40.4%            47.2%            42.2%            40.6%            22.5%                            | 
|TERMINAL (d)       |        9/16 (56%)       11/23 (48%)      13/24 (54%)      8/23 (35%)       0/8 (0%)                         | 
|FIRST INCIDENCE    |        626              540              540              521              409                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.318N         P=0.578N         P=0.354N         P=0.384N         P=0.383N                         | 
|POLY 3             |        P=0.022N*        P=0.346          P=0.527          P=0.586          P=0.073N                         | 
|POLY 1.5           |        P=0.017N*        P=0.296          P=0.452          P=0.529          P=0.072N                         | 
|POLY 6             |        P=0.031N*        P=0.414          P=0.589N         P=0.531N         P=0.081N                         | 
|LOGISTIC REGRESSION|        P=0.049N*        P=0.360          P=0.552N         P=0.580          P=0.118N                         | 
|COCH-ARM / FISHERS |        P=0.019N*        P=0.224          P=0.362          P=0.442          P=0.085N                         | 
|ORDER RESTRICTED   |        P=0.044N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        3/53 (6%)        0/53 (0%)        0/53 (0%)        18/51 (35%)                      | 
|POLY-3 RATE (b)    |        0/35.78          3/39.99          0/41.29          0/39.44          18/35.67                         | 
|POLY-3 PERCENT (g) |        0.0%             7.5%             0.0%             0.0%             50.5%                            | 
|TERMINAL (d)       |        0/16 (0%)        3/23 (13%)       0/24 (0%)        0/23 (0%)        5/8 (63%)                        | 
|FIRST INCIDENCE    |        ---              729 (T)          ---              ---              542                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.189          (e)              (e)              P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.139          (e)              (e)              P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.133          (e)              (e)              P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.145          (e)              (e)              P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.189          (e)              (e)              P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.125          (e)              (e)              P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/52 (17%)       15/53 (28%)      19/53 (36%)      25/53 (47%)      16/51 (31%)                      | 
|POLY-3 RATE (b)    |        9/36.94          15/40.83         19/45.42         25/42.75         16/36.44                         | 
|POLY-3 PERCENT (g) |        24.4%            36.7%            41.8%            58.5%            43.9%                            | 
|TERMINAL (d)       |        3/16 (19%)       12/23 (52%)      7/24 (29%)       14/23 (61%)      3/8 (38%)                        | 
|FIRST INCIDENCE    |        631              626              322              521              339                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.367          P=0.171          P=0.022 *        P=0.016 *                        | 
|POLY 3             |        P=0.051          P=0.169          P=0.073          P<0.001 **       P=0.056                          | 
|POLY 1.5           |        P=0.076          P=0.158          P=0.046 *        P<0.001 **       P=0.067                          | 
|POLY 6             |        P=0.030 *        P=0.177          P=0.116          P=0.002 **       P=0.043 *                        | 
|LOGISTIC REGRESSION|        P=0.035 *        P=0.217          P=0.041 *        P=0.002 **       P=0.043 *                        | 
|COCH-ARM / FISHERS |        P=0.108          P=0.134          P=0.026 *        P<0.001 **       P=0.075                          | 
|ORDER RESTRICTED   |        P=0.012 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        12/52 (23%)      26/53 (49%)      23/53 (43%)      25/53 (47%)      21/51 (41%)                      | 
|POLY-3 RATE (b)    |        12/38.26         26/43.34         23/44.01         25/43.25         21/38.22                         | 
|POLY-3 PERCENT (g) |        31.4%            60.0%            52.3%            57.8%            54.9%                            | 
|TERMINAL (d)       |        4/16 (25%)       17/23 (74%)      12/24 (50%)      17/23 (74%)      4/8 (50%)                        | 
|FIRST INCIDENCE    |        444              362              540              322              409                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.063          P=0.194          P=0.080          P=0.006 **                       | 
|POLY 3             |        P=0.149          P=0.006 **       P=0.040 *        P=0.010 *        P=0.024 *                        | 
|POLY 1.5           |        P=0.187          P=0.005 **       P=0.028 *        P=0.009 **       P=0.031 *                        | 
|POLY 6             |        P=0.106          P=0.005 **       P=0.060          P=0.011 *        P=0.017 *                        | 
|LOGISTIC REGRESSION|        P=0.099          P=0.009 **       P=0.047 *        P=0.013 *        P=0.026 *                        | 
|COCH-ARM / FISHERS |        P=0.220          P=0.005 **       P=0.022 *        P=0.008 **       P=0.039 *                        | 
|ORDER RESTRICTED   |        P=0.017 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        44/52 (85%)      45/53 (85%)      47/53 (89%)      46/53 (87%)      45/51 (88%)                      | 
|POLY-3 RATE (b)    |        44/46.43         45/48.41         47/49.20         46/47.51         45/48.26                         | 
|POLY-3 PERCENT (g) |        94.8%            93.0%            95.5%            96.8%            93.2%                            | 
|TERMINAL (d)       |        16/16 (100%)     21/23 (91%)      23/24 (96%)      23/23 (100%)     8/8 (100%)                       | 
|FIRST INCIDENCE    |        176              456              322              469              339                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.115N         P=0.100N         P=0.131N         P=0.036 *                        | 
|POLY 3             |        P=0.524N         P=0.530N         P=0.641          P=0.510          P=0.558N                         | 
|POLY 1.5           |        P=0.576          P=0.586N         P=0.442          P=0.483          P=0.663N                         | 
|POLY 6             |        P=0.475N         P=0.425N         P=0.636N         P=0.653          P=0.441N                         | 
|LOGISTIC REGRESSION|        P=0.238          P=0.377N         P=0.555          P=0.556N         P=0.408                          | 
|COCH-ARM / FISHERS |        P=0.355          P=0.590          P=0.373          P=0.484          P=0.403                          | 
|ORDER RESTRICTED   |        P=0.561N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/52 (4%)        0/53 (0%)        2/53 (4%)        0/53 (0%)        2/51 (4%)                        | 
|POLY-3 RATE (b)    |        2/36.52          0/39.99          2/41.70          0/39.44          2/33.02                          | 
|POLY-3 PERCENT (g) |        5.5%             0.0%             4.8%             0.0%             6.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        1/24 (4%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        587              ---              609              ---              542                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.371          P=0.214N         P=0.600N         P=0.208N         P=0.634                          | 
|POLY 3             |        P=0.438          P=0.217N         P=0.646N         P=0.220N         P=0.659                          | 
|POLY 1.5           |        P=0.454          P=0.222N         P=0.664N         P=0.224N         P=0.676                          | 
|POLY 6             |        P=0.418          P=0.212N         P=0.627N         P=0.216N         P=0.628                          | 
|LOGISTIC REGRESSION|        P=0.471          P=0.235N         P=0.681N         P=0.234N         P=0.686                          | 
|COCH-ARM / FISHERS |        P=0.474          P=0.243N         P=0.684N         P=0.243N         P=0.684                          | 
|ORDER RESTRICTED   |        P=0.366          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/52 (12%)       13/53 (25%)      11/53 (21%)      7/53 (13%)       15/51 (29%)                      | 
|POLY-3 RATE (b)    |        6/37.18          13/42.22         11/42.51         7/40.51          15/37.60                         | 
|POLY-3 PERCENT (g) |        16.1%            30.8%            25.9%            17.3%            39.9%                            | 
|TERMINAL (d)       |        3/16 (19%)       7/23 (30%)       5/24 (21%)       5/23 (22%)       2/8 (25%)                        | 
|FIRST INCIDENCE    |        508              362              609              276              409                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.191          P=0.359          P=0.540N         P=0.006 **                       | 
|POLY 3             |        P=0.055          P=0.099          P=0.215          P=0.568          P=0.017 *                        | 
|POLY 1.5           |        P=0.064          P=0.089          P=0.185          P=0.553          P=0.019 *                        | 
|POLY 6             |        P=0.045 *        P=0.111          P=0.253          P=0.578          P=0.014 *                        | 
|LOGISTIC REGRESSION|        P=0.049 *        P=0.088          P=0.218          P=0.547          P=0.020 *                        | 
|COCH-ARM / FISHERS |        P=0.071          P=0.069          P=0.155          P=0.515          P=0.022 *                        | 
|ORDER RESTRICTED   |        P=0.014 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/52 (19%)      21/53 (40%)      12/53 (23%)      15/53 (28%)      9/51 (18%)                       | 
|POLY-3 RATE (b)    |        10/38.22         21/44.37         12/42.79         15/42.26         9/34.64                          | 
|POLY-3 PERCENT (g) |        26.2%            47.3%            28.0%            35.5%            26.0%                            | 
|TERMINAL (d)       |        4/16 (25%)       9/23 (39%)       8/24 (33%)       7/23 (30%)       1/8 (13%)                        | 
|FIRST INCIDENCE    |        416              456              456              469              387                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.487          P=0.112          P=0.462N         P=0.408          P=0.367                          | 
|POLY 3             |        P=0.228N         P=0.035 *        P=0.524          P=0.250          P=0.600N                         | 
|POLY 1.5           |        P=0.174N         P=0.026 *        P=0.480          P=0.227          P=0.553N                         | 
|POLY 6             |        P=0.313N         P=0.051          P=0.571          P=0.287          P=0.549                          | 
|LOGISTIC REGRESSION|        P=0.191N         P=0.026 *        P=0.501          P=0.230          P=0.556N                         | 
|COCH-ARM / FISHERS |        P=0.139N         P=0.018 *        P=0.425          P=0.195          P=0.519N                         | 
|ORDER RESTRICTED   |        P=0.263N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta                                                                                                              | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        1/52 (2%)        3/53 (6%)                        | 
|POLY-3 RATE (b)    |        0/36.25          0/39.99          0/41.29          1/39.84          3/33.55                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.5%             8.9%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              585              399                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       (e)              (e)              P=0.520          P=0.083                          | 
|POLY 3             |        P=0.004 **       (e)              (e)              P=0.519          P=0.104                          | 
|POLY 1.5           |        P=0.005 **       (e)              (e)              P=0.511          P=0.110                          | 
|POLY 6             |        P=0.004 **       (e)              (e)              P=0.529          P=0.093                          | 
|LOGISTIC REGRESSION|        P=0.009 **       (e)              (e)              P=0.478          P=0.124                          | 
|COCH-ARM / FISHERS |        P=0.006 **       (e)              (e)              P=0.495          P=0.121                          | 
|ORDER RESTRICTED   |        P=0.008 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        36/53 (68%)      36/53 (68%)      34/53 (64%)      41/53 (77%)      48/53 (91%)                      | 
|POLY-3 RATE (b)    |        36/50.20         36/50.51         34/50.03         41/50.63         48/49.64                         | 
|POLY-3 PERCENT (g) |        71.7%            71.3%            68.0%            81.0%            96.7%                            | 
|TERMINAL (d)       |        7/16 (44%)       12/23 (52%)      13/24 (54%)      16/23 (70%)      8/8 (100%)                       | 
|FIRST INCIDENCE    |        176              227              46               276              2                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.231N         P=0.113N         P=0.425N         P=0.005 **                       | 
|POLY 3             |        P<0.001 **       P=0.570N         P=0.423N         P=0.187          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.573N         P=0.438N         P=0.188          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.571N         P=0.407N         P=0.188          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.456          P=0.531N         P=0.135          P=0.005 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.582N         P=0.419N         P=0.192          P=0.004 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        1/53 (2%)        3/53 (6%)                        | 
|POLY-3 RATE (b)    |        0/36.25          0/39.99          0/41.29          1/39.67          3/32.57                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.5%             9.2%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              668              689                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.557          P=0.056                          | 
|POLY 3             |        P=0.004 **       (e)              (e)              P=0.518          P=0.099                          | 
|POLY 1.5           |        P=0.005 **       (e)              (e)              P=0.511          P=0.107                          | 
|POLY 6             |        P=0.003 **       (e)              (e)              P=0.527          P=0.087                          | 
|LOGISTIC REGRESSION|        P=0.002 **       (e)              (e)              P=0.512          P=0.069                          | 
|COCH-ARM / FISHERS |        P=0.006 **       (e)              (e)              P=0.500          P=0.121                          | 
|ORDER RESTRICTED   |        P=0.008 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hydrocephalus                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        4/53 (8%)        2/53 (4%)        2/53 (4%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        1/36.31          4/40.48          2/41.52          2/40.30          0/32.33                          | 
|POLY-3 PERCENT (g) |        2.8%             9.9%             4.8%             5.0%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        1/23 (4%)        1/24 (4%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        715              652              666              521              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.216N         P=0.267          P=0.597          P=0.560          P=0.586N                         | 
|POLY 3             |        P=0.161N         P=0.212          P=0.547          P=0.536          P=0.523N                         | 
|POLY 1.5           |        P=0.148N         P=0.199          P=0.526          P=0.522          P=0.513N                         | 
|POLY 6             |        P=0.181N         P=0.229          P=0.571          P=0.554          P=0.540N                         | 
|LOGISTIC REGRESSION|        P=0.155N         P=0.221          P=0.569          P=0.503          P=0.570N                         | 
|COCH-ARM / FISHERS |        P=0.132N         P=0.181          P=0.500          P=0.500          P=0.500N                         | 
|ORDER RESTRICTED   |        P=0.190N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        3/53 (6%)                        | 
|POLY-3 RATE (b)    |        0/36.25          0/39.99          0/41.29          0/39.44          3/32.88                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             9.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              631                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.070                          | 
|POLY 3             |        P=0.002 **       (e)              (e)              (e)              P=0.100                          | 
|POLY 1.5           |        P=0.003 **       (e)              (e)              (e)              P=0.108                          | 
|POLY 6             |        P=0.002 **       (e)              (e)              (e)              P=0.089                          | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P=0.091                          | 
|COCH-ARM / FISHERS |        P=0.003 **       (e)              (e)              (e)              P=0.121                          | 
|ORDER RESTRICTED   |        P=0.003 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        42/51 (82%)      40/53 (75%)      37/53 (70%)      33/51 (65%)      29/50 (58%)                      | 
|POLY-3 RATE (b)    |        42/48.64         40/47.16         37/48.66         33/45.67         29/42.47                         | 
|POLY-3 PERCENT (g) |        86.4%            84.8%            76.0%            72.3%            68.3%                            | 
|TERMINAL (d)       |        12/16 (75%)      20/23 (87%)      18/24 (75%)      19/23 (83%)      5/8 (63%)                        | 
|FIRST INCIDENCE    |        176              416              203              333              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.432          P=0.081N         P=0.026N*        P=0.010N*        P=0.442N                         | 
|POLY 3             |        P=0.009N**       P=0.533N         P=0.133N         P=0.060N         P=0.021N*                        | 
|POLY 1.5           |        P=0.005N**       P=0.443N         P=0.130N         P=0.050N         P=0.011N*                        | 
|POLY 6             |        P=0.025N*        P=0.602N         P=0.144N         P=0.079N         P=0.055N                         | 
|LOGISTIC REGRESSION|        P=0.006N**       P=0.212N         P=0.101N         P=0.035N*        P=0.006N**                       | 
|COCH-ARM / FISHERS |        P=0.004N**       P=0.269N         P=0.102N         P=0.036N*        P=0.007N**                       | 
|ORDER RESTRICTED   |        P=0.018N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Duct                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        39/51 (76%)      41/53 (77%)      44/53 (83%)      39/51 (76%)      44/50 (88%)                      | 
|POLY-3 RATE (b)    |        39/47.81         41/49.28         44/48.86         39/45.91         44/47.66                         | 
|POLY-3 PERCENT (g) |        81.6%            83.2%            90.1%            85.0%            92.3%                            | 
|TERMINAL (d)       |        12/16 (75%)      19/23 (83%)      22/24 (92%)      20/23 (87%)      8/8 (100%)                       | 
|FIRST INCIDENCE    |        176              350              203              465              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.214N         P=0.226N         P=0.134N         P=0.022 *                        | 
|POLY 3             |        P=0.075          P=0.523          P=0.163          P=0.431          P=0.081                          | 
|POLY 1.5           |        P=0.085          P=0.514          P=0.159          P=0.463          P=0.088                          | 
|POLY 6             |        P=0.065          P=0.555          P=0.198          P=0.436          P=0.078                          | 
|LOGISTIC REGRESSION|        P=0.080          P=0.549          P=0.321          P=0.540N         P=0.113                          | 
|COCH-ARM / FISHERS |        P=0.099          P=0.549          P=0.279          P=0.592N         P=0.105                          | 
|ORDER RESTRICTED   |        P=0.070          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus: Muscularis                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/53 (4%)        1/53 (2%)        1/53 (2%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        0/36.25          2/40.36          1/41.88          1/39.67          0/32.33                          | 
|POLY-3 PERCENT (g) |        0.0%             5.0%             2.4%             2.5%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        1/23 (4%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              626              540              668              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.428N         P=0.299          P=0.528          P=0.557          (e)                              | 
|POLY 3             |        P=0.376N         P=0.261          P=0.529          P=0.518          (e)                              | 
|POLY 1.5           |        P=0.364N         P=0.252          P=0.516          P=0.511          (e)                              | 
|POLY 6             |        P=0.391N         P=0.273          P=0.543          P=0.527          (e)                              | 
|LOGISTIC REGRESSION|        P=0.356N         P=0.256          P=0.487          P=0.512          (e)                              | 
|COCH-ARM / FISHERS |        P=0.349N         P=0.248          P=0.500          P=0.500          (e)                              | 
|ORDER RESTRICTED   |        P=0.415N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        1/53 (2%)        2/53 (4%)        1/53 (2%)        3/53 (6%)                        | 
|POLY-3 RATE (b)    |        1/36.43          1/39.99          2/41.62          1/39.44          3/33.15                          | 
|POLY-3 PERCENT (g) |        2.7%             2.5%             4.8%             2.5%             9.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        1/23 (4%)        0/24 (0%)        1/23 (4%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        682              729 (T)          669              729 (T)          548                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.065          P=0.698N         P=0.602          P=0.702N         P=0.206                          | 
|POLY 3             |        P=0.153          P=0.740N         P=0.546          P=0.744N         P=0.270                          | 
|POLY 1.5           |        P=0.166          P=0.747N         P=0.526          P=0.750N         P=0.285                          | 
|POLY 6             |        P=0.136          P=0.732N         P=0.570          P=0.737N         P=0.247                          | 
|LOGISTIC REGRESSION|        P=0.131          P=0.729N         P=0.544          P=0.734N         P=0.270                          | 
|COCH-ARM / FISHERS |        P=0.187          P=0.752N         P=0.500          P=0.752N         P=0.309                          | 
|ORDER RESTRICTED   |        P=0.166          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/53 (15%)       11/53 (21%)      4/52 (8%)        5/53 (9%)        7/53 (13%)                       | 
|POLY-3 RATE (b)    |        8/37.39          11/42.44         4/41.42          5/39.67          7/34.50                          | 
|POLY-3 PERCENT (g) |        21.4%            25.9%            9.7%             12.6%            20.3%                            | 
|TERMINAL (d)       |        5/16 (31%)       7/23 (30%)       1/24 (4%)        4/23 (17%)       2/8 (25%)                        | 
|FIRST INCIDENCE    |        456              350              526              669              392                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.392          P=0.563          P=0.069N         P=0.114N         P=0.368                          | 
|POLY 3             |        P=0.405N         P=0.416          P=0.126N         P=0.232N         P=0.570N                         | 
|POLY 1.5           |        P=0.368N         P=0.376          P=0.152N         P=0.248N         P=0.539N                         | 
|POLY 6             |        P=0.453N         P=0.464          P=0.100N         P=0.213N         P=0.619N                         | 
|LOGISTIC REGRESSION|        P=0.390N         P=0.354          P=0.146N         P=0.205N         P=0.576N                         | 
|COCH-ARM / FISHERS |        P=0.319N         P=0.307          P=0.189N         P=0.278N         P=0.500N                         | 
|ORDER RESTRICTED   |        P=0.241N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/53 (21%)      26/53 (49%)      31/53 (58%)      30/52 (58%)      32/53 (60%)                      | 
|POLY-3 RATE (b)    |        11/38.34         26/42.78         31/46.88         30/45.60         32/40.84                         | 
|POLY-3 PERCENT (g) |        28.7%            60.8%            66.1%            65.8%            78.4%                            | 
|TERMINAL (d)       |        7/16 (44%)       18/23 (78%)      16/24 (67%)      14/23 (61%)      6/8 (75%)                        | 
|FIRST INCIDENCE    |        416              350              203              276              339                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.029 *        P=0.009 **       P=0.010 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.004 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/52 (4%)        4/53 (8%)        5/53 (9%)        1/53 (2%)        0/52 (0%)                        | 
|POLY-3 RATE (b)    |        2/36.81          4/41.74          5/41.91          1/39.84          0/31.71                          | 
|POLY-3 PERCENT (g) |        5.4%             9.6%             11.9%            2.5%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        4/24 (17%)       0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        508              548              526              616              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.078N         P=0.405          P=0.350          P=0.467N         P=0.268N                         | 
|POLY 3             |        P=0.063N         P=0.396          P=0.270          P=0.472N         P=0.271N                         | 
|POLY 1.5           |        P=0.054N         P=0.378          P=0.250          P=0.479N         P=0.255N                         | 
|POLY 6             |        P=0.076N         P=0.419          P=0.291          P=0.465N         P=0.296N                         | 
|LOGISTIC REGRESSION|        P=0.046N*        P=0.310          P=0.239          P=0.516N         P=0.227N                         | 
|COCH-ARM / FISHERS |        P=0.046N*        P=0.348          P=0.226          P=0.493N         P=0.248N                         | 
|ORDER RESTRICTED   |        P=0.111N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum: Artery                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        0/53 (0%)        0/53 (0%)        2/53 (4%)        3/52 (6%)                        | 
|POLY-3 RATE (b)    |        0/35.78          0/39.99          0/41.29          2/39.44          3/32.29                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.1%             9.3%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        2/23 (9%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              729 (T)          617                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.320          P=0.065                          | 
|POLY 3             |        P=0.005 **       (e)              (e)              P=0.259          P=0.099                          | 
|POLY 1.5           |        P=0.006 **       (e)              (e)              P=0.253          P=0.108                          | 
|POLY 6             |        P=0.004 **       (e)              (e)              P=0.266          P=0.089                          | 
|LOGISTIC REGRESSION|        P=0.003 **       (e)              (e)              P=0.320          P=0.093                          | 
|COCH-ARM / FISHERS |        P=0.009 **       (e)              (e)              P=0.252          P=0.121                          | 
|ORDER RESTRICTED   |        P=0.015 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        0/53 (0%)        1/53 (2%)        2/53 (4%)        0/51 (0%)                        | 
|POLY-3 RATE (b)    |        0/35.78          0/39.99          1/41.31          2/39.44          0/32.27                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.4%             5.1%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        2/23 (9%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              723              729 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.478          (e)              P=0.566          P=0.320          (e)                              | 
|POLY 3             |        P=0.537          (e)              P=0.529          P=0.259          (e)                              | 
|POLY 1.5           |        P=0.582          (e)              P=0.518          P=0.253          (e)                              | 
|POLY 6             |        P=0.465          (e)              P=0.541          P=0.266          (e)                              | 
|LOGISTIC REGRESSION|        P=0.511          (e)              P=0.558          P=0.320          (e)                              | 
|COCH-ARM / FISHERS |        P=0.621          (e)              P=0.505          P=0.252          (e)                              | 
|ORDER RESTRICTED   |        P=0.333          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Calculus Micro Observation Only                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/52 (17%)       5/53 (9%)        8/53 (15%)       4/53 (8%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        9/38.17          5/40.94          8/42.43          4/40.36          1/32.78                          | 
|POLY-3 PERCENT (g) |        23.6%            12.2%            18.9%            9.9%             3.1%                             | 
|TERMINAL (d)       |        3/16 (19%)       2/23 (9%)        4/24 (17%)       3/23 (13%)       0/8 (0%)                         | 
|FIRST INCIDENCE    |        484              626              548              315              575                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.033N*        P=0.102N         P=0.268N         P=0.057N         P=0.040N*                        | 
|POLY 3             |        P=0.015N*        P=0.149N         P=0.403N         P=0.089N         P=0.014N*                        | 
|POLY 1.5           |        P=0.011N*        P=0.159N         P=0.438N         P=0.094N         P=0.011N*                        | 
|POLY 6             |        P=0.023N*        P=0.137N         P=0.365N         P=0.086N         P=0.021N*                        | 
|LOGISTIC REGRESSION|        P=0.010N*        P=0.161N         P=0.429N         P=0.105N         P=0.012N*                        | 
|COCH-ARM / FISHERS |        P=0.009N**       P=0.184N         P=0.483N         P=0.110N         P=0.009N**                       | 
|ORDER RESTRICTED   |        P=0.011N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/52 (6%)        2/53 (4%)        3/53 (6%)        3/53 (6%)        6/51 (12%)                       | 
|POLY-3 RATE (b)    |        3/36.39          2/40.02          3/41.98          3/40.84          6/33.36                          | 
|POLY-3 PERCENT (g) |        8.2%             5.0%             7.2%             7.4%             18.0%                            | 
|TERMINAL (d)       |        1/16 (6%)        1/23 (4%)        1/24 (4%)        1/23 (4%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        631              721              592              315              598                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.015 *        P=0.390N         P=0.521N         P=0.566N         P=0.105                          | 
|POLY 3             |        P=0.057          P=0.456N         P=0.596N         P=0.609N         P=0.194                          | 
|POLY 1.5           |        P=0.068          P=0.467N         P=0.621N         P=0.623N         P=0.217                          | 
|POLY 6             |        P=0.046 *        P=0.447N         P=0.568N         P=0.595N         P=0.161                          | 
|LOGISTIC REGRESSION|        P=0.065          P=0.440N         P=0.622N         P=0.659          P=0.175                          | 
|COCH-ARM / FISHERS |        P=0.080          P=0.491N         P=0.652N         P=0.652N         P=0.234                          | 
|ORDER RESTRICTED   |        P=0.083          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        41/52 (79%)      48/53 (91%)      47/53 (89%)      42/53 (79%)      35/51 (69%)                      | 
|POLY-3 RATE (b)    |        41/49.10         48/50.96         47/52.49         42/49.44         35/47.77                         | 
|POLY-3 PERCENT (g) |        83.5%            94.2%            89.5%            85.0%            73.3%                            | 
|TERMINAL (d)       |        12/16 (75%)      22/23 (96%)      21/24 (88%)      18/23 (78%)      3/8 (38%)                        | 
|FIRST INCIDENCE    |        176              227              46               276              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.220          P=0.404N         P=0.286N         P=0.184N         P=0.351                          | 
|POLY 3             |        P=0.006N**       P=0.067          P=0.265          P=0.533          P=0.151N                         | 
|POLY 1.5           |        P=0.005N**       P=0.068          P=0.210          P=0.547          P=0.149N                         | 
|POLY 6             |        P=0.010N*        P=0.070          P=0.315          P=0.524          P=0.179N                         | 
|LOGISTIC REGRESSION|        P=0.006N**       P=0.085          P=0.107          P=0.579          P=0.123N                         | 
|COCH-ARM / FISHERS |        P=0.008N**       P=0.080          P=0.135          P=0.575          P=0.170N                         | 
|ORDER RESTRICTED   |        P=0.013N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        26/52 (50%)      41/53 (77%)      40/53 (75%)      47/53 (89%)      49/51 (96%)                      | 
|POLY-3 RATE (b)    |        26/41.83         41/47.66         40/47.07         47/49.32         49/50.00                         | 
|POLY-3 PERCENT (g) |        62.2%            86.0%            85.0%            95.3%            98.0%                            | 
|TERMINAL (d)       |        9/16 (56%)       23/23 (100%)     20/24 (83%)      23/23 (100%)     8/8 (100%)                       | 
|FIRST INCIDENCE    |        416              227              203              276              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.188          P=0.319          P=0.048 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.004 **       P=0.007 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.004 **       P=0.005 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.003 **       P=0.012 *        P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.006 **       P=0.013 *        P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.003 **       P=0.006 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/52 (4%)        0/53 (0%)        1/53 (2%)        1/53 (2%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        2/36.75          0/39.99          1/41.29          1/39.44          1/32.65                          | 
|POLY-3 PERCENT (g) |        5.4%             0.0%             2.4%             2.5%             3.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        1/24 (4%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        484              ---              729 (T)          729 (T)          623                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.579          P=0.215N         P=0.416N         P=0.426N         P=0.558N                         | 
|POLY 3             |        P=0.620          P=0.218N         P=0.459N         P=0.475N         P=0.541N                         | 
|POLY 1.5           |        P=0.614N         P=0.223N         P=0.474N         P=0.481N         P=0.522N                         | 
|POLY 6             |        P=0.586          P=0.214N         P=0.445N         P=0.470N         P=0.573N                         | 
|LOGISTIC REGRESSION|        P=0.603N         P=0.254N         P=0.497N         P=0.496N         P=0.504N                         | 
|COCH-ARM / FISHERS |        P=0.595N         P=0.243N         P=0.493N         P=0.493N         P=0.507N                         | 
|ORDER RESTRICTED   |        P=0.338N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/52 (4%)        1/53 (2%)        1/53 (2%)        2/53 (4%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        2/36.44          1/40.87          1/41.29          2/39.44          1/32.27                          | 
|POLY-3 PERCENT (g) |        5.5%             2.5%             2.4%             5.1%             3.1%                             | 
|TERMINAL (d)       |        1/16 (6%)        0/23 (0%)        1/24 (4%)        2/23 (9%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        508              362              729 (T)          729 (T)          729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.562          P=0.446N         P=0.391N         P=0.587N         P=0.660N                         | 
|POLY 3             |        P=0.576N         P=0.460N         P=0.456N         P=0.666N         P=0.543N                         | 
|POLY 1.5           |        P=0.549N         P=0.471N         P=0.472N         P=0.673N         P=0.522N                         | 
|POLY 6             |        P=0.582          P=0.449N         P=0.439N         P=0.659N         P=0.576N                         | 
|LOGISTIC REGRESSION|        P=0.528N         P=0.555N         P=0.479N         P=0.665N         P=0.528N                         | 
|COCH-ARM / FISHERS |        P=0.519N         P=0.493N         P=0.493N         P=0.684N         P=0.507N                         | 
|ORDER RESTRICTED   |        P=0.537N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        0/53 (0%)        0/53 (0%)        2/53 (4%)        0/51 (0%)                        | 
|POLY-3 RATE (b)    |        0/35.78          0/39.99          0/41.29          2/39.44          0/32.27                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.1%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        2/23 (9%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              729 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.405          (e)              (e)              P=0.320          (e)                              | 
|POLY 3             |        P=0.449          (e)              (e)              P=0.259          (e)                              | 
|POLY 1.5           |        P=0.499          (e)              (e)              P=0.253          (e)                              | 
|POLY 6             |        P=0.373          (e)              (e)              P=0.266          (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.320          (e)                              | 
|COCH-ARM / FISHERS |        P=0.545          (e)              (e)              P=0.252          (e)                              | 
|ORDER RESTRICTED   |        P=0.241          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/52 (10%)       5/53 (9%)        8/53 (15%)       10/53 (19%)      8/51 (16%)                       | 
|POLY-3 RATE (b)    |        5/36.97          5/40.89          8/42.32          10/42.99         8/34.22                          | 
|POLY-3 PERCENT (g) |        13.5%            12.2%            18.9%            23.3%            23.4%                            | 
|TERMINAL (d)       |        2/16 (13%)       1/23 (4%)        4/24 (17%)       4/23 (17%)       2/8 (25%)                        | 
|FIRST INCIDENCE    |        484              626              621              276              434                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.024 *        P=0.478N         P=0.498          P=0.256          P=0.100                          | 
|POLY 3             |        P=0.104          P=0.567N         P=0.366          P=0.203          P=0.218                          | 
|POLY 1.5           |        P=0.134          P=0.584N         P=0.331          P=0.181          P=0.246                          | 
|POLY 6             |        P=0.068          P=0.543N         P=0.411          P=0.230          P=0.175                          | 
|LOGISTIC REGRESSION|        P=0.149          P=0.581N         P=0.351          P=0.128          P=0.233                          | 
|COCH-ARM / FISHERS |        P=0.167          P=0.617N         P=0.290          P=0.141          P=0.265                          | 
|ORDER RESTRICTED   |        P=0.227          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        2/53 (4%)        0/53 (0%)        0/53 (0%)        3/51 (6%)                        | 
|POLY-3 RATE (b)    |        3/37.02          2/40.10          0/41.29          0/39.44          3/33.56                          | 
|POLY-3 PERCENT (g) |        8.1%             5.0%             0.0%             0.0%             8.9%                             | 
|TERMINAL (d)       |        2/16 (13%)       1/23 (4%)        0/24 (0%)        0/23 (0%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        444              702              ---              ---              409                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.278          P=0.377N         P=0.077N         P=0.081N         P=0.477                          | 
|POLY 3             |        P=0.423          P=0.463N         P=0.100N         P=0.107N         P=0.618                          | 
|POLY 1.5           |        P=0.436          P=0.476N         P=0.108N         P=0.111N         P=0.635                          | 
|POLY 6             |        P=0.410          P=0.447N         P=0.090N         P=0.101N         P=0.588                          | 
|LOGISTIC REGRESSION|        P=0.449          P=0.470N         P=0.118N         P=0.118N         P=0.647                          | 
|COCH-ARM / FISHERS |        P=0.451          P=0.500N         P=0.121N         P=0.121N         P=0.642                          | 
|ORDER RESTRICTED   |        P=0.203          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        24/53 (45%)      26/53 (49%)      13/53 (25%)      12/53 (23%)      16/51 (31%)                      | 
|POLY-3 RATE (b)    |        24/40.97         26/46.22         13/44.27         12/42.39         16/38.67                         | 
|POLY-3 PERCENT (g) |        58.6%            56.3%            29.4%            28.3%            41.4%                            | 
|TERMINAL (d)       |        7/16 (44%)       9/23 (39%)       4/24 (17%)       3/23 (13%)       0/8 (0%)                         | 
|FIRST INCIDENCE    |        444              362              263              505              434                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.371N         P=0.341N         P=0.004N**       P=0.004N**       P=0.453N                         | 
|POLY 3             |        P=0.051N         P=0.499N         P=0.004N**       P=0.003N**       P=0.083N                         | 
|POLY 1.5           |        P=0.042N*        P=0.583N         P=0.007N**       P=0.005N**       P=0.082N                         | 
|POLY 6             |        P=0.067N         P=0.412N         P=0.003N**       P=0.002N**       P=0.097N                         | 
|LOGISTIC REGRESSION|        P=0.053N         P=0.532          P=0.011N*        P=0.006N**       P=0.123N                         | 
|COCH-ARM / FISHERS |        P=0.043N*        P=0.423          P=0.020N*        P=0.012N*        P=0.104N                         | 
|ORDER RESTRICTED   |        P=0.012N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/53 (4%)        3/53 (6%)        4/53 (8%)        17/51 (33%)                      | 
|POLY-3 RATE (b)    |        0/36.25          2/40.10          3/41.39          4/40.46          17/36.02                         | 
|POLY-3 PERCENT (g) |        0.0%             5.0%             7.3%             9.9%             47.2%                            | 
|TERMINAL (d)       |        0/16 (0%)        1/23 (4%)        2/24 (8%)        2/23 (9%)        2/8 (25%)                        | 
|FIRST INCIDENCE    |        ---              702              702              521              392                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.309          P=0.199          P=0.097          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.260          P=0.143          P=0.074          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.252          P=0.132          P=0.069          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.270          P=0.158          P=0.082          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.278          P=0.170          P=0.066          P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.248          P=0.121          P=0.059          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        0/53 (0%)        0/53 (0%)        1/53 (2%)        2/51 (4%)                        | 
|POLY-3 RATE (b)    |        1/36.43          0/39.99          0/41.29          1/39.44          2/32.99                          | 
|POLY-3 PERCENT (g) |        2.7%             0.0%             0.0%             2.5%             6.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        682              ---              ---              729 (T)          563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.063          P=0.462N         P=0.443N         P=0.702N         P=0.421                          | 
|POLY 3             |        P=0.108          P=0.481N         P=0.475N         P=0.744N         P=0.465                          | 
|POLY 1.5           |        P=0.119          P=0.488N         P=0.486N         P=0.750N         P=0.479                          | 
|POLY 6             |        P=0.095          P=0.474N         P=0.463N         P=0.737N         P=0.442                          | 
|LOGISTIC REGRESSION|        P=0.114          P=0.481N         P=0.476N         P=0.734N         P=0.475                          | 
|COCH-ARM / FISHERS |        P=0.132          P=0.500N         P=0.500N         P=0.752N         P=0.485                          | 
|ORDER RESTRICTED   |        P=0.119          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/53 (9%)        9/53 (17%)       11/53 (21%)      20/53 (38%)      19/51 (37%)                      | 
|POLY-3 RATE (b)    |        5/36.93          9/41.59          11/44.12         20/44.09         19/39.91                         | 
|POLY-3 PERCENT (g) |        13.5%            21.6%            24.9%            45.4%            47.6%                            | 
|TERMINAL (d)       |        4/16 (25%)       3/23 (13%)       3/24 (13%)       6/23 (26%)       4/8 (50%)                        | 
|FIRST INCIDENCE    |        500              455              322              465              387                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.377          P=0.247          P=0.010 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.260          P=0.157          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.234          P=0.122          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.298          P=0.210          P=0.003 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.242          P=0.101          P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.195          P=0.087          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        5/53 (9%)        14/53 (26%)      34/53 (64%)      36/51 (71%)                      | 
|POLY-3 RATE (b)    |        3/37.54          5/41.40          14/43.52         34/43.92         36/40.75                         | 
|POLY-3 PERCENT (g) |        8.0%             12.1%            32.2%            77.4%            88.3%                            | 
|TERMINAL (d)       |        0/16 (0%)        1/23 (4%)        6/24 (25%)       21/23 (91%)      8/8 (100%)                       | 
|FIRST INCIDENCE    |        484              227              456              465              409                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.464          P=0.029 *        P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.410          P=0.007 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.394          P=0.005 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.428          P=0.010 *        P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.327          P=0.006 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.358          P=0.003 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        4/53 (8%)        7/53 (13%)       2/53 (4%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        3/37.06          4/41.52          7/41.85          2/39.99          1/33.11                          | 
|POLY-3 PERCENT (g) |        8.1%             9.6%             16.7%            5.0%             3.0%                             | 
|TERMINAL (d)       |        2/16 (13%)       1/23 (4%)        4/24 (17%)       0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        416              455              652              626              399                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.199N         P=0.610          P=0.329          P=0.412N         P=0.444N                         | 
|POLY 3             |        P=0.120N         P=0.562          P=0.208          P=0.465N         P=0.345N                         | 
|POLY 1.5           |        P=0.106N         P=0.539          P=0.184          P=0.479N         P=0.329N                         | 
|POLY 6             |        P=0.143N         P=0.592          P=0.242          P=0.446N         P=0.374N                         | 
|LOGISTIC REGRESSION|        P=0.100N         P=0.483          P=0.207          P=0.494N         P=0.317N                         | 
|COCH-ARM / FISHERS |        P=0.096N         P=0.500          P=0.160          P=0.500N         P=0.324N                         | 
|ORDER RESTRICTED   |        P=0.186N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        16/53 (30%)      18/53 (34%)      19/53 (36%)      8/53 (15%)       9/51 (18%)                       | 
|POLY-3 RATE (b)    |        16/43.39         18/46.29         19/47.14         8/42.48          9/36.40                          | 
|POLY-3 PERCENT (g) |        36.9%            38.9%            40.3%            18.8%            24.7%                            | 
|TERMINAL (d)       |        2/16 (13%)       5/23 (22%)       7/24 (29%)       1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        176              227              263              322              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.104N         P=0.503N         P=0.507N         P=0.036N*        P=0.260N                         | 
|POLY 3             |        P=0.035N*        P=0.509          P=0.452          P=0.048N*        P=0.173N                         | 
|POLY 1.5           |        P=0.022N*        P=0.472          P=0.395          P=0.050N         P=0.136N                         | 
|POLY 6             |        P=0.059N         P=0.558          P=0.518          P=0.045N*        P=0.236N                         | 
|LOGISTIC REGRESSION|        P=0.008N**       P=0.295          P=0.258          P=0.074N         P=0.089N                         | 
|COCH-ARM / FISHERS |        P=0.013N*        P=0.418          P=0.340          P=0.052N         P=0.102N                         | 
|ORDER RESTRICTED   |        P=0.084N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/53 (2%)        3/53 (6%)        11/53 (21%)      38/51 (75%)                      | 
|POLY-3 RATE (b)    |        0/36.25          1/40.22          3/41.75          11/41.10         38/42.93                         | 
|POLY-3 PERCENT (g) |        0.0%             2.5%             7.2%             26.8%            88.5%                            | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        2/24 (8%)        6/23 (26%)       6/8 (75%)                        | 
|FIRST INCIDENCE    |        ---              668              592              548              392                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.540          P=0.188          P=0.003 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.521          P=0.145          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.513          P=0.133          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.530          P=0.161          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.514          P=0.140          P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500          P=0.121          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        36/53 (68%)      50/53 (94%)      45/53 (85%)      50/53 (94%)      50/51 (98%)                      | 
|POLY-3 RATE (b)    |        36/46.12         50/52.12         45/49.17         50/51.02         50/50.79                         | 
|POLY-3 PERCENT (g) |        78.1%            95.9%            91.5%            98.0%            98.4%                            | 
|TERMINAL (d)       |        13/16 (81%)      21/23 (91%)      23/24 (96%)      23/23 (100%)     8/8 (100%)                       | 
|FIRST INCIDENCE    |        176              227              203              276              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.337          P=0.406N         P=0.332          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.003 **       P=0.039 *        P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P=0.025 *        P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P=0.005 **       P=0.019 *        P=0.071          P<0.001 **       P=0.002 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P=0.049 *        P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P=0.033 *        P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        21/53 (40%)      32/53 (60%)      35/53 (66%)      36/53 (68%)      17/51 (33%)                      | 
|POLY-3 RATE (b)    |        21/38.34         32/44.41         35/45.79         36/44.24         17/38.70                         | 
|POLY-3 PERCENT (g) |        54.8%            72.1%            76.4%            81.4%            43.9%                            | 
|TERMINAL (d)       |        15/16 (94%)      20/23 (87%)      22/24 (92%)      22/23 (96%)      5/8 (63%)                        | 
|FIRST INCIDENCE    |        387              455              322              469              339                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.193          P=0.313          P=0.225          P=0.108          P=0.250                          | 
|POLY 3             |        P=0.019N*        P=0.061          P=0.019 *        P=0.003 **       P=0.219N                         | 
|POLY 1.5           |        P=0.019N*        P=0.040 *        P=0.008 **       P=0.002 **       P=0.246N                         | 
|POLY 6             |        P=0.026N*        P=0.115          P=0.053          P=0.007 **       P=0.199N                         | 
|LOGISTIC REGRESSION|        P=0.121N         P=0.056          P=0.021 *        P=0.004 **       P=0.377N                         | 
|COCH-ARM / FISHERS |        P=0.047N*        P=0.026 *        P=0.006 **       P=0.003 **       P=0.322N                         | 
|ORDER RESTRICTED   |        P=0.004N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        1/53 (2%)        9/53 (17%)       3/53 (6%)        15/51 (29%)                      | 
|POLY-3 RATE (b)    |        3/37.19          1/40.57          9/44.14          3/41.00          15/38.07                         | 
|POLY-3 PERCENT (g) |        8.1%             2.5%             20.4%            7.3%             39.4%                            | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        1/24 (4%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        625              546              456              490              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.263N         P=0.142          P=0.591N         P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.274N         P=0.105          P=0.618N         P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.284N         P=0.083          P=0.634N         P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.264N         P=0.134          P=0.601N         P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.311N         P=0.062          P=0.646          P=0.002 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.309N         P=0.061          P=0.661N         P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        35/53 (66%)      41/53 (77%)      48/53 (91%)      51/51 (100%)                     | 
|POLY-3 RATE (b)    |        4/37.02          35/47.45         41/46.41         48/49.41         51/51.00                         | 
|POLY-3 PERCENT (g) |        10.8%            73.8%            88.3%            97.1%            100.0%                           | 
|TERMINAL (d)       |        0/16 (0%)        14/23 (61%)      23/24 (96%)      23/23 (100%)     8/8 (100%)                       | 
|FIRST INCIDENCE    |        631              362              456              322              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Toxic Hepatopathy                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        5/53 (9%)        14/53 (26%)      38/53 (72%)      47/51 (92%)                      | 
|POLY-3 RATE (b)    |        0/36.25          5/40.51          14/42.54         38/44.69         47/48.74                         | 
|POLY-3 PERCENT (g) |        0.0%             12.3%            32.9%            85.0%            96.4%                            | 
|TERMINAL (d)       |        0/16 (0%)        2/23 (9%)        9/24 (38%)       23/23 (100%)     7/8 (88%)                        | 
|FIRST INCIDENCE    |        ---              627              456              465              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.067          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.040 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.036 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.045 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.045 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.028 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        3/53 (6%)        3/53 (6%)        4/53 (8%)        9/51 (18%)                       | 
|POLY-3 RATE (b)    |        1/36.25          3/39.99          3/41.40          4/39.81          9/34.57                          | 
|POLY-3 PERCENT (g) |        2.8%             7.5%             7.3%             10.1%            26.0%                            | 
|TERMINAL (d)       |        1/16 (6%)        3/23 (13%)       2/24 (8%)        3/23 (13%)       1/8 (13%)                        | 
|FIRST INCIDENCE    |        729 (T)          729 (T)          699              626              562                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.441          P=0.457          P=0.283          P=0.003 **                       | 
|POLY 3             |        P<0.001 **       P=0.340          P=0.354          P=0.206          P=0.005 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.328          P=0.332          P=0.196          P=0.006 **                       | 
|POLY 6             |        P<0.001 **       P=0.356          P=0.380          P=0.221          P=0.004 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.441          P=0.408          P=0.221          P=0.005 **                       | 
|COCH-ARM / FISHERS |        P=0.002 **       P=0.309          P=0.309          P=0.181          P=0.007 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        2/53 (4%)        1/53 (2%)        5/53 (9%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        3/36.43          2/40.22          1/41.29          5/39.44          1/32.31                          | 
|POLY-3 PERCENT (g) |        8.2%             5.0%             2.4%             12.7%            3.1%                             | 
|TERMINAL (d)       |        2/16 (13%)       1/23 (4%)        1/24 (4%)        5/23 (22%)       0/8 (0%)                         | 
|FIRST INCIDENCE    |        682              668              729 (T)          729 (T)          721                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.490          P=0.368N         P=0.183N         P=0.551          P=0.516N                         | 
|POLY 3             |        P=0.519N         P=0.455N         P=0.261N         P=0.399          P=0.348N                         | 
|POLY 1.5           |        P=0.472N         P=0.471N         P=0.280N         P=0.384          P=0.330N                         | 
|POLY 6             |        P=0.567          P=0.435N         P=0.241N         P=0.417          P=0.380N                         | 
|LOGISTIC REGRESSION|        P=0.585          P=0.427N         P=0.214N         P=0.459          P=0.433N                         | 
|COCH-ARM / FISHERS |        P=0.426N         P=0.500N         P=0.309N         P=0.358          P=0.324N                         | 
|ORDER RESTRICTED   |        P=0.351N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        3/53 (6%)        5/53 (9%)        25/53 (47%)      42/51 (82%)                      | 
|POLY-3 RATE (b)    |        2/36.25          3/40.21          5/41.76          25/42.11         42/45.06                         | 
|POLY-3 PERCENT (g) |        5.5%             7.5%             12.0%            59.4%            93.2%                            | 
|TERMINAL (d)       |        2/16 (13%)       1/23 (4%)        2/24 (8%)        17/23 (74%)      8/8 (100%)                       | 
|FIRST INCIDENCE    |        729 (T)          683              659              505              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.646          P=0.386          P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.547          P=0.276          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.530          P=0.248          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.570          P=0.311          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.590          P=0.316          P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500          P=0.219          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        2/53 (4%)        1/53 (2%)        1/53 (2%)        6/51 (12%)                       | 
|POLY-3 RATE (b)    |        3/37.69          2/41.10          1/42.28          1/39.84          6/34.96                          | 
|POLY-3 PERCENT (g) |        8.0%             4.9%             2.4%             2.5%             17.2%                            | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        454              362              46               616              392                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.029 *        P=0.453N         P=0.278N         P=0.276N         P=0.174                          | 
|POLY 3             |        P=0.038 *        P=0.460N         P=0.264N         P=0.284N         P=0.200                          | 
|POLY 1.5           |        P=0.042 *        P=0.473N         P=0.279N         P=0.291N         P=0.216                          | 
|POLY 6             |        P=0.033 *        P=0.448N         P=0.250N         P=0.277N         P=0.175                          | 
|LOGISTIC REGRESSION|        P=0.056          P=0.565N         P=0.317N         P=0.326N         P=0.227                          | 
|COCH-ARM / FISHERS |        P=0.050          P=0.500N         P=0.309N         P=0.309N         P=0.225                          | 
|ORDER RESTRICTED   |        P=0.023 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        27/53 (51%)      34/53 (64%)      46/53 (87%)      50/51 (98%)                      | 
|POLY-3 RATE (b)    |        1/36.84          27/47.43         34/47.70         46/50.65         50/50.16                         | 
|POLY-3 PERCENT (g) |        2.7%             56.9%            71.3%            90.8%            99.7%                            | 
|TERMINAL (d)       |        0/16 (0%)        9/23 (39%)       15/24 (63%)      19/23 (83%)      8/8 (100%)                       | 
|FIRST INCIDENCE    |        540              350              263              276              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        12/53 (23%)      10/53 (19%)      39/53 (74%)      51/51 (100%)                     | 
|POLY-3 RATE (b)    |        0/36.25          12/41.65         10/42.90         39/46.55         51/51.00                         | 
|POLY-3 PERCENT (g) |        0.0%             28.8%            23.3%            83.8%            100.0%                           | 
|TERMINAL (d)       |        0/16 (0%)        6/23 (26%)       5/24 (21%)       20/23 (87%)      8/8 (100%)                       | 
|FIRST INCIDENCE    |        ---              546              456              465              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.002 **       P=0.007 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P<0.001 **       P=0.002 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P<0.001 **       P=0.003 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P=0.002 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/53 (2%)        1/53 (2%)        26/53 (49%)      42/51 (82%)                      | 
|POLY-3 RATE (b)    |        0/36.25          1/40.04          1/41.29          26/42.56         42/45.01                         | 
|POLY-3 PERCENT (g) |        0.0%             2.5%             2.4%             61.1%            93.3%                            | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        1/24 (4%)        16/23 (70%)      8/8 (100%)                       | 
|FIRST INCIDENCE    |        ---              718              729 (T)          505              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.555          P=0.581          P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.520          P=0.526          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.513          P=0.514          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.528          P=0.539          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.540          P=0.581          P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500          P=0.500          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        11/51 (22%)                      | 
|POLY-3 RATE (b)    |        0/36.25          0/39.99          0/41.29          0/39.44          11/34.70                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             31.7%                            | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              497                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        2/53 (4%)        2/53 (4%)        1/53 (2%)                        | 
|POLY-3 RATE (b)    |        0/36.25          0/39.99          2/42.28          2/40.18          1/33.18                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             4.7%             5.0%             3.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        1/24 (4%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              46               465              392                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.254          (e)              P=0.284          P=0.292          P=0.496                          | 
|POLY 3             |        P=0.277          (e)              P=0.273          P=0.260          P=0.482                          | 
|POLY 1.5           |        P=0.307          (e)              P=0.259          P=0.252          P=0.490                          | 
|POLY 6             |        P=0.234          (e)              P=0.289          P=0.271          P=0.468                          | 
|LOGISTIC REGRESSION|        P=0.435          (e)              P=0.231          P=0.226          P=0.553                          | 
|COCH-ARM / FISHERS |        P=0.348          (e)              P=0.248          P=0.248          P=0.500                          | 
|ORDER RESTRICTED   |        P=0.240          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        43/53 (81%)      50/53 (94%)      48/53 (91%)      48/53 (91%)      50/53 (94%)                      | 
|POLY-3 RATE (b)    |        43/48.76         50/51.23         48/50.38         48/49.84         50/50.63                         | 
|POLY-3 PERCENT (g) |        88.2%            97.6%            95.3%            96.3%            98.8%                            | 
|TERMINAL (d)       |        12/16 (75%)      22/23 (96%)      23/24 (96%)      23/23 (100%)     8/8 (100%)                       | 
|FIRST INCIDENCE    |        176              227              203              322              2                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.381N         P=0.199N         P=0.291N         P=0.011 *                        | 
|POLY 3             |        P=0.045 *        P=0.058          P=0.163          P=0.104          P=0.026 *                        | 
|POLY 1.5           |        P=0.054          P=0.043 *        P=0.130          P=0.114          P=0.024 *                        | 
|POLY 6             |        P=0.037 *        P=0.084          P=0.190          P=0.086          P=0.031 *                        | 
|LOGISTIC REGRESSION|        P=0.037 *        P=0.062          P=0.173          P=0.191          P=0.021 *                        | 
|COCH-ARM / FISHERS |        P=0.093          P=0.036 *        P=0.132          P=0.132          P=0.036 *                        | 
|ORDER RESTRICTED   |        P=0.004 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        2/53 (4%)        3/53 (6%)        1/53 (2%)        2/53 (4%)                        | 
|POLY-3 RATE (b)    |        4/36.94          2/40.38          3/43.60          1/40.14          2/33.97                          | 
|POLY-3 PERCENT (g) |        10.8%            5.0%             6.9%             2.5%             5.9%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        627              652              46               490              392                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.393N         P=0.251N         P=0.403N         P=0.143N         P=0.467N                         | 
|POLY 3             |        P=0.327N         P=0.295N         P=0.410N         P=0.152N         P=0.375N                         | 
|POLY 1.5           |        P=0.312N         P=0.310N         P=0.443N         P=0.162N         P=0.356N                         | 
|POLY 6             |        P=0.348N         P=0.280N         P=0.378N         P=0.144N         P=0.412N                         | 
|LOGISTIC REGRESSION|        P=0.221N         P=0.294N         P=0.543N         P=0.172N         P=0.331N                         | 
|COCH-ARM / FISHERS |        P=0.286N         P=0.339N         P=0.500N         P=0.181N         P=0.339N                         | 
|ORDER RESTRICTED   |        P=0.217N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/53 (0%)        2/53 (4%)        8/53 (15%)       11/53 (21%)                      | 
|POLY-3 RATE (b)    |        2/36.26          0/39.99          2/41.29          8/39.62          11/35.54                         | 
|POLY-3 PERCENT (g) |        5.5%             0.0%             4.8%             20.2%            31.0%                            | 
|TERMINAL (d)       |        1/16 (6%)        0/23 (0%)        2/24 (8%)        7/23 (30%)       2/8 (25%)                        | 
|FIRST INCIDENCE    |        727              ---              729 (T)          682              392                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.170N         P=0.547N         P=0.123          P=0.002 **                       | 
|POLY 3             |        P<0.001 **       P=0.215N         P=0.647N         P=0.058          P=0.004 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.223N         P=0.668N         P=0.053          P=0.005 **                       | 
|POLY 6             |        P<0.001 **       P=0.206N         P=0.622N         P=0.064          P=0.003 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.177N         P=0.547N         P=0.074          P=0.005 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.248N         P=0.691N         P=0.046 *        P=0.008 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        21/53 (40%)      25/53 (47%)      10/53 (19%)      2/53 (4%)        2/53 (4%)                        | 
|POLY-3 RATE (b)    |        21/38.66         25/45.19         10/43.44         2/40.34          2/33.72                          | 
|POLY-3 PERCENT (g) |        54.3%            55.3%            23.0%            5.0%             5.9%                             | 
|TERMINAL (d)       |        10/16 (63%)      11/23 (48%)      5/24 (21%)       1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        435              498              548              333              392                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.434N         P=0.002N**       P<0.001N**       P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.553          P=0.002N**       P<0.001N**       P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.431          P=0.005N**       P<0.001N**       P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.475N         P<0.001N**       P<0.001N**       P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.419          P=0.004N**       P<0.001N**       P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.278          P=0.016N*        P<0.001N**       P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        20/53 (38%)      33/53 (62%)      41/53 (77%)      40/53 (75%)                      | 
|POLY-3 RATE (b)    |        0/36.25          20/42.49         33/44.28         41/45.23         40/44.85                         | 
|POLY-3 PERCENT (g) |        0.0%             47.1%            74.5%            90.6%            89.2%                            | 
|TERMINAL (d)       |        0/16 (0%)        11/23 (48%)      19/24 (79%)      22/23 (96%)      8/8 (100%)                       | 
|FIRST INCIDENCE    |        ---              456              540              521              387                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/53 (2%)        1/53 (2%)        2/53 (4%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        0/36.25          1/39.99          1/41.55          2/39.44          0/32.33                          | 
|POLY-3 PERCENT (g) |        0.0%             2.5%             2.4%             5.1%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        1/23 (4%)        0/24 (0%)        2/23 (9%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              729 (T)          659              729 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.628          P=0.572          P=0.556          P=0.320          (e)                              | 
|POLY 3             |        P=0.609N         P=0.520          P=0.527          P=0.256          (e)                              | 
|POLY 1.5           |        P=0.583N         P=0.513          P=0.515          P=0.249          (e)                              | 
|POLY 6             |        P=0.597          P=0.528          P=0.541          P=0.264          (e)                              | 
|LOGISTIC REGRESSION|        P=0.657N         P=0.572          P=0.511          P=0.320          (e)                              | 
|COCH-ARM / FISHERS |        P=0.548N         P=0.500          P=0.500          P=0.248          (e)                              | 
|ORDER RESTRICTED   |        P=0.391          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        31/53 (58%)      42/53 (79%)      30/53 (57%)      22/53 (42%)      27/53 (51%)                      | 
|POLY-3 RATE (b)    |        31/42.81         42/46.79         30/44.94         22/42.31         27/42.85                         | 
|POLY-3 PERCENT (g) |        72.4%            89.8%            66.8%            52.0%            63.0%                            | 
|TERMINAL (d)       |        12/16 (75%)      22/23 (96%)      19/24 (79%)      13/23 (57%)      4/8 (50%)                        | 
|FIRST INCIDENCE    |        176              227              203              322              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.297          P=0.453          P=0.060N         P=0.007N**       P=0.254                          | 
|POLY 3             |        P=0.009N**       P=0.016 *        P=0.355N         P=0.031N*        P=0.223N                         | 
|POLY 1.5           |        P=0.011N*        P=0.015 *        P=0.414N         P=0.037N*        P=0.241N                         | 
|POLY 6             |        P=0.011N*        P=0.022 *        P=0.341N         P=0.032N*        P=0.246N                         | 
|LOGISTIC REGRESSION|        P=0.055N         P=0.037 *        P=0.319N         P=0.024N*        P=0.344N                         | 
|COCH-ARM / FISHERS |        P=0.020N*        P=0.018 *        P=0.500N         P=0.060N         P=0.279N                         | 
|ORDER RESTRICTED   |        P=0.006N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        0/53 (0%)        0/53 (0%)        1/53 (2%)        2/50 (4%)                        | 
|POLY-3 RATE (b)    |        0/35.78          0/39.99          0/41.29          1/39.44          2/32.31                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.5%             6.2%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              729 (T)          563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       (e)              (e)              P=0.572          P=0.190                          | 
|POLY 3             |        P=0.023 *        (e)              (e)              P=0.519          P=0.214                          | 
|POLY 1.5           |        P=0.026 *        (e)              (e)              P=0.514          P=0.223                          | 
|POLY 6             |        P=0.019 *        (e)              (e)              P=0.526          P=0.200                          | 
|LOGISTIC REGRESSION|        P=0.025 *        (e)              (e)              P=0.572          P=0.225                          | 
|COCH-ARM / FISHERS |        P=0.030 *        (e)              (e)              P=0.505          P=0.238                          | 
|ORDER RESTRICTED   |        P=0.037 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/4 (25%)        0/1 (0%)         0/2 (0%)         3/9 (33%)        0/11 (0%)                        | 
|POLY-3 RATE (b)    |        1/2.37           0/1.00           0/1.51           3/7.27           0/6.18                           | 
|POLY-3 PERCENT (g) |        42.3%            0.0%             0.0%             41.3%            0.0%                             | 
|TERMINAL (d)       |        0/0 (0%)         0/1 (0%)         0/0 (0%)         0/2 (0%)         0/2 (0%)                         | 
|FIRST INCIDENCE    |        682              ---              ---              322              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.605          P=0.459N         P=0.432N         P=0.343          P=0.605N                         | 
|POLY 3             |        P=0.263N         P=0.699N         P=0.600N         P=0.746N         P=0.283N                         | 
|POLY 1.5           |        P=0.215N         P=0.726N         P=0.612N         P=0.704          P=0.285N                         | 
|POLY 6             |        P=0.356N         P=0.647N         P=0.598N         P=0.708N         P=0.283N                         | 
|LOGISTIC REGRESSION|        P=0.132N         P=0.608N         P=0.487N         P=0.626          P=0.239N                         | 
|COCH-ARM / FISHERS |        P=0.169N         P=0.800N         P=0.667N         P=0.646          P=0.267N                         | 
|ORDER RESTRICTED   |        P=0.176N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         1/1 (100%)       0/2 (0%)         4/9 (44%)        2/11 (18%)                       | 
|POLY-3 RATE (b)    |        0/2.19           1/1.00           0/1.51           4/6.87           2/7.20                           | 
|POLY-3 PERCENT (g) |        0.0%             100.0%           0.0%             58.3%            27.8%                            | 
|TERMINAL (d)       |        0/0 (0%)         1/1 (100%)       0/0 (0%)         1/2 (50%)        0/2 (0%)                         | 
|FIRST INCIDENCE    |        ---              729 (T)          ---              548              498                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.176          P=1.000N         (e)              P=0.144          P=0.216                          | 
|POLY 3             |        P=0.483N         P=0.009 **       (e)              P=0.235          P=0.524                          | 
|POLY 1.5           |        P=0.532N         P<0.001 **       (e)              P=0.186          P=0.497                          | 
|POLY 6             |        P=0.396N         P=0.247          (e)              P=0.348          P=0.580                          | 
|LOGISTIC REGRESSION|        P=0.608N         P=1.000N         (e)              P=0.182          P=0.479                          | 
|COCH-ARM / FISHERS |        P=0.566N         P=0.200          (e)              P=0.176          P=0.524                          | 
|ORDER RESTRICTED   |        P=0.271          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         0/1 (0%)         0/2 (0%)         1/9 (11%)        2/11 (18%)                       | 
|POLY-3 RATE (b)    |        0/2.19           0/1.00           0/1.51           1/5.93           2/6.71                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             16.9%            29.8%                            | 
|TERMINAL (d)       |        0/0 (0%)         0/1 (0%)         0/0 (0%)         0/2 (0%)         1/2 (50%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              619              563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.056          (e)              (e)              P=0.516          P=0.477                          | 
|POLY 3             |        P=0.207          (e)              (e)              P=0.693          P=0.506                          | 
|POLY 1.5           |        P=0.226          (e)              (e)              P=0.674          P=0.488                          | 
|POLY 6             |        P=0.182          (e)              (e)              P=0.728          P=0.553                          | 
|LOGISTIC REGRESSION|        P=0.206          (e)              (e)              P=0.679          P=0.493                          | 
|COCH-ARM / FISHERS |        P=0.236          (e)              (e)              P=0.692          P=0.524                          | 
|ORDER RESTRICTED   |        P=0.332          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         0/1 (0%)         0/2 (0%)         1/9 (11%)        3/11 (27%)                       | 
|POLY-3 RATE (b)    |        0/2.19           0/1.00           0/1.51           1/6.11           3/8.15                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             16.4%            36.8%                            | 
|TERMINAL (d)       |        0/0 (0%)         0/1 (0%)         0/0 (0%)         0/2 (0%)         0/2 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              548              392                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.004 **       (e)              (e)              P=0.515          P=0.113                          | 
|POLY 3             |        P=0.123          (e)              (e)              P=0.697          P=0.418                          | 
|POLY 1.5           |        P=0.121          (e)              (e)              P=0.676          P=0.374                          | 
|POLY 6             |        P=0.123          (e)              (e)              P=0.732          P=0.495                          | 
|LOGISTIC REGRESSION|        P=0.142          (e)              (e)              P=0.667          P=0.351                          | 
|COCH-ARM / FISHERS |        P=0.108          (e)              (e)              P=0.692          P=0.363                          | 
|ORDER RESTRICTED   |        P=0.277          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         0/1 (0%)         0/2 (0%)         0/9 (0%)         2/11 (18%)                       | 
|POLY-3 RATE (b)    |        0/2.19           0/1.00           0/1.51           0/5.54           2/7.61                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             26.3%                            | 
|TERMINAL (d)       |        0/0 (0%)         0/1 (0%)         0/0 (0%)         0/2 (0%)         0/2 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              387                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.020 *        (e)              (e)              (e)              P=0.240                          | 
|POLY 3             |        P=0.141          (e)              (e)              (e)              P=0.537                          | 
|POLY 1.5           |        P=0.143          (e)              (e)              (e)              P=0.507                          | 
|POLY 6             |        P=0.136          (e)              (e)              (e)              P=0.591                          | 
|LOGISTIC REGRESSION|        P=0.169          (e)              (e)              (e)              P=0.547                          | 
|COCH-ARM / FISHERS |        P=0.136          (e)              (e)              (e)              P=0.524                          | 
|ORDER RESTRICTED   |        P=0.297          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         0/1 (0%)         0/2 (0%)         0/9 (0%)         2/11 (18%)                       | 
|POLY-3 RATE (b)    |        0/2.19           0/1.00           0/1.51           0/5.54           2/6.50                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             30.8%                            | 
|TERMINAL (d)       |        0/0 (0%)         0/1 (0%)         0/0 (0%)         0/2 (0%)         1/2 (50%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              639                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.046 *        (e)              (e)              (e)              P=0.462                          | 
|POLY 3             |        P=0.116          (e)              (e)              (e)              P=0.498                          | 
|POLY 1.5           |        P=0.128          (e)              (e)              (e)              P=0.483                          | 
|POLY 6             |        P=0.101          (e)              (e)              (e)              P=0.541                          | 
|LOGISTIC REGRESSION|        P=0.094          (e)              (e)              (e)              P=0.530                          | 
|COCH-ARM / FISHERS |        P=0.136          (e)              (e)              (e)              P=0.524                          | 
|ORDER RESTRICTED   |        P=0.227          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        3/53 (6%)        1/53 (2%)        1/53 (2%)        0/52 (0%)                        | 
|POLY-3 RATE (b)    |        0/36.25          3/40.88          1/41.29          1/39.44          0/32.27                          | 
|POLY-3 PERCENT (g) |        0.0%             7.3%             2.4%             2.5%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        2/23 (9%)        1/24 (4%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              350              729 (T)          729 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.369N         P=0.170          P=0.581          P=0.572          (e)                              | 
|POLY 3             |        P=0.269N         P=0.141          P=0.526          P=0.517          (e)                              | 
|POLY 1.5           |        P=0.261N         P=0.133          P=0.514          P=0.511          (e)                              | 
|POLY 6             |        P=0.282N         P=0.150          P=0.539          P=0.524          (e)                              | 
|LOGISTIC REGRESSION|        P=0.265N         P=0.110          P=0.581          P=0.572          (e)                              | 
|COCH-ARM / FISHERS |        P=0.255N         P=0.121          P=0.500          P=0.500          (e)                              | 
|ORDER RESTRICTED   |        P=0.292N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        22/53 (42%)      7/53 (13%)       14/53 (26%)      12/53 (23%)      9/52 (17%)                       | 
|POLY-3 RATE (b)    |        22/41.93         7/42.31          14/43.62         12/40.19         9/35.05                          | 
|POLY-3 PERCENT (g) |        52.5%            16.6%            32.1%            29.9%            25.7%                            | 
|TERMINAL (d)       |        8/16 (50%)       4/23 (17%)       6/24 (25%)       8/23 (35%)       1/8 (13%)                        | 
|FIRST INCIDENCE    |        416              362              322              668              497                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.355N         P<0.001N**       P=0.016N*        P=0.006N**       P=0.100N                         | 
|POLY 3             |        P=0.110N         P<0.001N**       P=0.039N*        P=0.026N*        P=0.011N*                        | 
|POLY 1.5           |        P=0.080N         P<0.001N**       P=0.051N         P=0.025N*        P=0.007N**                       | 
|POLY 6             |        P=0.155N         P<0.001N**       P=0.030N*        P=0.027N*        P=0.021N*                        | 
|LOGISTIC REGRESSION|        P=0.071N         P<0.001N**       P=0.054N         P=0.016N*        P=0.008N**                       | 
|COCH-ARM / FISHERS |        P=0.050N         P<0.001N**       P=0.075N         P=0.030N*        P=0.006N**                       | 
|ORDER RESTRICTED   |        P=0.008N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        4/53 (8%)        1/53 (2%)        3/53 (6%)        1/52 (2%)                        | 
|POLY-3 RATE (b)    |        3/38.20          4/41.28          1/41.29          3/40.36          1/32.81                          | 
|POLY-3 PERCENT (g) |        7.9%             9.7%             2.4%             7.4%             3.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        1/23 (4%)        1/24 (4%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        387              540              729 (T)          465              563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.301N         P=0.576          P=0.251N         P=0.601N         P=0.330N                         | 
|POLY 3             |        P=0.265N         P=0.543          P=0.277N         P=0.638N         P=0.360N                         | 
|POLY 1.5           |        P=0.240N         P=0.527          P=0.290N         P=0.646N         P=0.338N                         | 
|POLY 6             |        P=0.299N         P=0.562          P=0.264N         P=0.628N         P=0.397N                         | 
|LOGISTIC REGRESSION|        P=0.193N         P=0.446          P=0.327N         P=0.621          P=0.282N                         | 
|COCH-ARM / FISHERS |        P=0.209N         P=0.500          P=0.309N         P=0.661N         P=0.316N                         | 
|ORDER RESTRICTED   |        P=0.291N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/0 (0%)         0/1 (0%)         0/2 (0%)         0/6 (0%)         2/8 (25%)                        | 
|POLY-3 RATE (b)    |        0/0.00           0/0.96           0/1.76           0/5.10           2/7.62                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             26.2%                            | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/4 (0%)         0/3 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.010 *        (e)              (e)              (e)              P=0.198                          | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.280          (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.181          (e)              (e)              (e)              P=1.000                          | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Artery                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/0 (0%)         1/1 (100%)       0/2 (0%)         3/6 (50%)        6/8 (75%)                        | 
|POLY-3 RATE (b)    |        0/0.00           1/1.00           0/1.76           3/5.10           6/6.90                           | 
|POLY-3 PERCENT (g) |        0.0%             100.0%           0.0%             58.8%            87.0%                            | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/1 (0%)         3/4 (75%)        3/3 (100%)                       | 
|FIRST INCIDENCE    |        ---              718              ---              729 (T)          634                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=1.000N         P=0.065                          | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.118          (e)              (e)              P=1.000N         (e)                              | 
|COCH-ARM / FISHERS |        P=0.201          (e)              (e)              P=1.000          P=1.000                          | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/0 (0%)         0/1 (0%)         1/2 (50%)        2/6 (33%)        0/8 (0%)                         | 
|POLY-3 RATE (b)    |        0/0.00           0/0.96           1/1.76           2/5.77           0/6.52                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             56.7%            34.7%            0.0%                             | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         1/1 (100%)       1/4 (25%)        0/3 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              729 (T)          505              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.361N         (e)              P=1.000N         P=0.535          (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.111N         (e)              P=1.000N         (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.131N         (e)              P=1.000          P=1.000          (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        2/53 (4%)        2/53 (4%)        1/53 (2%)        1/53 (2%)                        | 
|POLY-3 RATE (b)    |        1/36.25          2/40.02          2/41.37          1/39.44          1/32.34                          | 
|POLY-3 PERCENT (g) |        2.8%             5.0%             4.8%             2.5%             3.1%                             | 
|TERMINAL (d)       |        1/16 (6%)        1/23 (4%)        1/24 (4%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        729 (T)          721              709              729 (T)          728                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.587          P=0.610          P=0.623          P=0.680N         P=0.626                          | 
|POLY 3             |        P=0.485N         P=0.535          P=0.546          P=0.742N         P=0.736                          | 
|POLY 1.5           |        P=0.470N         P=0.522          P=0.526          P=0.749N         P=0.747                          | 
|POLY 6             |        P=0.504N         P=0.550          P=0.569          P=0.734N         P=0.717                          | 
|LOGISTIC REGRESSION|        P=0.630          P=0.588          P=0.601          P=0.680N         (e)                              | 
|COCH-ARM / FISHERS |        P=0.448N         P=0.500          P=0.500          P=0.752N         P=0.752N                         | 
|ORDER RESTRICTED   |        P=0.645N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Goblet Cell                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        2/53 (4%)        1/53 (2%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        0/36.25          0/39.99          2/41.29          1/39.44          0/32.33                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             4.8%             2.5%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        2/24 (8%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              729 (T)          729 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.670          (e)              P=0.330          P=0.572          (e)                              | 
|POLY 3             |        P=0.608N         (e)              P=0.267          P=0.517          (e)                              | 
|POLY 1.5           |        P=0.591N         (e)              P=0.253          P=0.511          (e)                              | 
|POLY 6             |        P=0.633N         (e)              P=0.282          P=0.524          (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.330          P=0.572          (e)                              | 
|COCH-ARM / FISHERS |        P=0.566N         (e)              P=0.248          P=0.500          (e)                              | 
|ORDER RESTRICTED   |        P=0.350          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/53 (2%)        0/53 (0%)        4/53 (8%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        0/36.25          1/40.53          0/41.29          4/41.30          0/32.33                          | 
|POLY-3 PERCENT (g) |        0.0%             2.5%             0.0%             9.7%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        2/23 (9%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              562              ---              276              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.467          P=0.519          (e)              P=0.093          (e)                              | 
|POLY 3             |        P=0.409          P=0.522          (e)              P=0.078          (e)                              | 
|POLY 1.5           |        P=0.473          P=0.514          (e)              P=0.072          (e)                              | 
|POLY 6             |        P=0.318          P=0.532          (e)              P=0.085          (e)                              | 
|LOGISTIC REGRESSION|        P=0.613          P=0.475          (e)              P=0.040 *        (e)                              | 
|COCH-ARM / FISHERS |        P=0.556          P=0.500          (e)              P=0.059          (e)                              | 
|ORDER RESTRICTED   |        P=0.143          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/10 (80%)       17/18 (94%)      18/19 (95%)      26/29 (90%)      30/31 (97%)                      | 
|POLY-3 RATE (b)    |        8/9.41           17/17.46         18/18.62         26/28.23         30/30.32                         | 
|POLY-3 PERCENT (g) |        85.1%            97.4%            96.7%            92.1%            99.0%                            | 
|TERMINAL (d)       |        1/1 (100%)       6/6 (100%)       9/9 (100%)       12/13 (92%)      5/5 (100%)                       | 
|FIRST INCIDENCE    |        387              455              529              315              339                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.354          P=0.564          P=0.165          P<0.001 **                       | 
|POLY 3             |        P=0.202          P=0.313          P=0.340          P=0.502          P=0.123                          | 
|POLY 1.5           |        P=0.197          P=0.295          P=0.303          P=0.448          P=0.118                          | 
|POLY 6             |        P=0.267          P=0.409          P=0.455          P=0.625          P=0.205                          | 
|LOGISTIC REGRESSION|        P=0.194          P=0.310          P=0.300          P=0.361          P=0.149                          | 
|COCH-ARM / FISHERS |        P=0.215          P=0.284          P=0.267          P=0.381          P=0.142                          | 
|ORDER RESTRICTED   |        P=0.103          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        44/52 (85%)      44/52 (85%)      43/53 (81%)      49/53 (92%)      40/51 (78%)                      | 
|POLY-3 RATE (b)    |        44/47.70         44/48.76         43/49.42         49/52.38         40/46.65                         | 
|POLY-3 PERCENT (g) |        92.3%            90.3%            87.0%            93.6%            85.8%                            | 
|TERMINAL (d)       |        15/16 (94%)      21/23 (91%)      21/24 (88%)      21/23 (91%)      7/8 (88%)                        | 
|FIRST INCIDENCE    |        218              350              263              276              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.015 *        P=0.103N         P=0.048N*        P=0.289N         P=0.148                          | 
|POLY 3             |        P=0.255N         P=0.505N         P=0.290N         P=0.560          P=0.218N                         | 
|POLY 1.5           |        P=0.222N         P=0.539N         P=0.364N         P=0.416          P=0.212N                         | 
|POLY 6             |        P=0.334N         P=0.470N         P=0.216N         P=0.680N         P=0.257N                         | 
|LOGISTIC REGRESSION|        P=0.356N         P=0.450N         P=0.308N         P=0.208          P=0.296N                         | 
|COCH-ARM / FISHERS |        P=0.301N         P=0.607N         P=0.416N         P=0.170          P=0.290N                         | 
|ORDER RESTRICTED   |        P=0.220N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/52 (15%)       16/52 (31%)      20/53 (38%)      14/53 (26%)      7/51 (14%)                       | 
|POLY-3 RATE (b)    |        8/37.42          16/42.04         20/44.38         14/41.51         7/33.43                          | 
|POLY-3 PERCENT (g) |        21.4%            38.1%            45.1%            33.7%            20.9%                            | 
|TERMINAL (d)       |        4/16 (25%)       7/23 (30%)       8/24 (33%)       9/23 (39%)       2/8 (25%)                        | 
|FIRST INCIDENCE    |        176              546              456              505              589                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.546          P=0.203          P=0.085          P=0.306          P=0.388                          | 
|POLY 3             |        P=0.181N         P=0.080          P=0.018 *        P=0.161          P=0.598N                         | 
|POLY 1.5           |        P=0.129N         P=0.065          P=0.011 *        P=0.144          P=0.556N                         | 
|POLY 6             |        P=0.277N         P=0.106          P=0.034 *        P=0.185          P=0.576                          | 
|LOGISTIC REGRESSION|        P=0.162N         P=0.074          P=0.014 *        P=0.153          P=0.572N                         | 
|COCH-ARM / FISHERS |        P=0.094N         P=0.051          P=0.008 **       P=0.125          P=0.516N                         | 
|ORDER RESTRICTED   |        P=0.165N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        2/52 (4%)        1/53 (2%)        2/53 (4%)        5/51 (10%)                       | 
|POLY-3 RATE (b)    |        0/35.78          2/39.98          1/41.29          2/40.14          5/34.86                          | 
|POLY-3 PERCENT (g) |        0.0%             5.0%             2.4%             5.0%             14.3%                            | 
|TERMINAL (d)       |        0/16 (0%)        1/23 (4%)        1/24 (4%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              669              729 (T)          490              434                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.305          P=0.581          P=0.290          P=0.027 *                        | 
|POLY 3             |        P=0.008 **       P=0.262          P=0.528          P=0.263          P=0.027 *                        | 
|POLY 1.5           |        P=0.009 **       P=0.253          P=0.518          P=0.255          P=0.029 *                        | 
|POLY 6             |        P=0.007 **       P=0.273          P=0.540          P=0.272          P=0.023 *                        | 
|LOGISTIC REGRESSION|        P=0.011 *        P=0.268          P=0.581          P=0.235          P=0.031 *                        | 
|COCH-ARM / FISHERS |        P=0.010 *        P=0.248          P=0.505          P=0.252          P=0.027 *                        | 
|ORDER RESTRICTED   |        P=0.006 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oviduct                                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/0 (0%)         2/2 (100%)       0/0 (0%)         0/2 (0%)         1/5 (20%)                        | 
|POLY-3 RATE (b)    |        0/0.00           2/2.00           0/0.00           0/1.89           1/3.03                           | 
|POLY-3 PERCENT (g) |        0.0%             100.0%           0.0%             0.0%             33.0%                            | 
|TERMINAL (d)       |        0/0 (0%)         1/1 (100%)       0/0 (0%)         0/1 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              702              ---              ---              623                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.460          (e)              (e)              (e)              P=0.462                          | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.446N         (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.143N         (e)              (e)              (e)              P=1.000                          | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oviduct                                                                                                                          | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/0 (0%)         0/2 (0%)         0/0 (0%)         2/2 (100%)       4/5 (80%)                        | 
|POLY-3 RATE (b)    |        0/0.00           0/1.89           0/0.00           2/2.00           4/4.62                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             100.0%           86.5%                            | 
|TERMINAL (d)       |        0/0 (0%)         0/1 (0%)         0/0 (0%)         1/1 (100%)       0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              702              498                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.046 *                        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.446          (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.143          (e)              (e)              (e)              P=1.000                          | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/52 (6%)        1/53 (2%)        6/53 (11%)       7/53 (13%)       16/51 (31%)                      | 
|POLY-3 RATE (b)    |        3/36.17          1/39.99          6/42.48          7/40.33          16/36.75                         | 
|POLY-3 PERCENT (g) |        8.3%             2.5%             14.1%            17.4%            43.5%                            | 
|TERMINAL (d)       |        1/16 (6%)        1/23 (4%)        1/24 (4%)        5/23 (22%)       4/8 (50%)                        | 
|FIRST INCIDENCE    |        625              729 (T)          526              505              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.218N         P=0.408          P=0.298          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.269N         P=0.325          P=0.201          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.278N         P=0.292          P=0.188          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.259N         P=0.366          P=0.216          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.252N         P=0.300          P=0.203          P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.302N         P=0.254          P=0.167          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/52 (6%)        2/53 (4%)        7/53 (13%)       7/53 (13%)       20/51 (39%)                      | 
|POLY-3 RATE (b)    |        3/36.18          2/40.89          7/42.48          7/40.91          20/38.26                         | 
|POLY-3 PERCENT (g) |        8.3%             4.9%             16.5%            17.1%            52.3%                            | 
|TERMINAL (d)       |        1/16 (6%)        0/23 (0%)        2/24 (8%)        4/23 (17%)       3/8 (38%)                        | 
|FIRST INCIDENCE    |        625              563              526              505              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.414N         P=0.313          P=0.282          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.444N         P=0.228          P=0.208          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.461N         P=0.199          P=0.192          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.424N         P=0.264          P=0.228          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.474N         P=0.213          P=0.191          P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.491N         P=0.167          P=0.167          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/52 (4%)        0/53 (0%)        1/53 (2%)        0/53 (0%)        0/51 (0%)                        | 
|POLY-3 RATE (b)    |        2/36.13          0/39.99          1/41.29          0/39.44          0/32.27                          | 
|POLY-3 PERCENT (g) |        5.5%             0.0%             2.4%             0.0%             0.0%                             | 
|TERMINAL (d)       |        1/16 (6%)        0/23 (0%)        1/24 (4%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        631              ---              729 (T)          ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.218N         P=0.188N         P=0.384N         P=0.188N         P=0.336N                         | 
|POLY 3             |        P=0.185N         P=0.214N         P=0.453N         P=0.217N         P=0.262N                         | 
|POLY 1.5           |        P=0.182N         P=0.220N         P=0.471N         P=0.222N         P=0.249N                         | 
|POLY 6             |        P=0.184N         P=0.208N         P=0.436N         P=0.212N         P=0.285N                         | 
|LOGISTIC REGRESSION|        P=0.192N         P=0.214N         P=0.438N         P=0.217N         P=0.269N                         | 
|COCH-ARM / FISHERS |        P=0.176N         P=0.243N         P=0.493N         P=0.243N         P=0.252N                         | 
|ORDER RESTRICTED   |        P=0.061N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/52 (2%)        0/53 (0%)        3/53 (6%)        15/53 (28%)      30/51 (59%)                      | 
|POLY-3 RATE (b)    |        1/35.96          0/39.99          3/41.39          15/40.98         30/39.27                         | 
|POLY-3 PERCENT (g) |        2.8%             0.0%             7.3%             36.6%            76.4%                            | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        2/24 (8%)        10/23 (44%)      7/8 (88%)                        | 
|FIRST INCIDENCE    |        682              ---              702              585              434                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.462N         P=0.443          P=0.002 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.479N         P=0.357          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.485N         P=0.337          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.473N         P=0.378          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.478N         P=0.389          P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.495N         P=0.316          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Artery                                                                                                                 | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        6/53 (11%)       3/53 (6%)        8/53 (15%)       14/51 (27%)                      | 
|POLY-3 RATE (b)    |        0/35.78          6/40.04          3/41.29          8/40.34          14/36.24                         | 
|POLY-3 PERCENT (g) |        0.0%             15.0%            7.3%             19.8%            38.6%                            | 
|TERMINAL (d)       |        0/16 (0%)        5/23 (22%)       3/24 (13%)       6/23 (26%)       3/8 (38%)                        | 
|FIRST INCIDENCE    |        ---              718              729 (T)          505              339                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.043 *        P=0.199          P=0.015 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.021 *        P=0.145          P=0.006 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.020 *        P=0.135          P=0.005 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.023 *        P=0.158          P=0.007 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.031 *        P=0.199          P=0.007 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.014 *        P=0.125          P=0.003 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        5/51 (10%)                       | 
|POLY-3 RATE (b)    |        0/35.78          0/39.99          0/41.29          0/39.44          5/32.79                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             15.3%                            | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        2/8 (25%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              639                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.008 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.022 *                        | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.026 *                        | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.017 *                        | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P=0.014 *                        | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.027 *                        | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        2/51 (4%)                        | 
|POLY-3 RATE (b)    |        0/35.78          0/39.99          0/41.29          0/39.44          2/32.78                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             6.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              639                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       (e)              (e)              (e)              P=0.182                          | 
|POLY 3             |        P=0.017 *        (e)              (e)              (e)              P=0.217                          | 
|POLY 1.5           |        P=0.018 *        (e)              (e)              (e)              P=0.226                          | 
|POLY 6             |        P=0.016 *        (e)              (e)              (e)              P=0.202                          | 
|LOGISTIC REGRESSION|        P=0.016 *        (e)              (e)              (e)              P=0.216                          | 
|COCH-ARM / FISHERS |        P=0.020 *        (e)              (e)              (e)              P=0.243                          | 
|ORDER RESTRICTED   |        P=0.013 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/53 (11%)       0/53 (0%)        1/53 (2%)        2/53 (4%)        3/53 (6%)                        | 
|POLY-3 RATE (b)    |        6/37.22          0/39.99          1/41.40          2/40.17          3/33.28                          | 
|POLY-3 PERCENT (g) |        16.1%            0.0%             2.4%             5.0%             9.0%                             | 
|TERMINAL (d)       |        3/16 (19%)       0/23 (0%)        0/24 (0%)        1/23 (4%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        575              ---              699              469              498                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.427          P=0.008N**       P=0.024N*        P=0.068N         P=0.467N                         | 
|POLY 3             |        P=0.555          P=0.011N*        P=0.039N*        P=0.106N         P=0.295N                         | 
|POLY 1.5           |        P=0.584          P=0.013N*        P=0.046N*        P=0.115N         P=0.271N                         | 
|POLY 6             |        P=0.522          P=0.010N*        P=0.033N*        P=0.098N         P=0.341N                         | 
|LOGISTIC REGRESSION|        P=0.586N         P=0.012N*        P=0.039N*        P=0.118N         P=0.299N                         | 
|COCH-ARM / FISHERS |        P=0.546N         P=0.013N*        P=0.056N         P=0.135N         P=0.244N                         | 
|ORDER RESTRICTED   |        P=0.026N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        0/53 (0%)        1/53 (2%)        2/53 (4%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        1/36.43          0/39.99          1/41.29          2/39.44          0/32.33                          | 
|POLY-3 PERCENT (g) |        2.7%             0.0%             2.4%             5.1%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        1/24 (4%)        2/23 (9%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        682              ---              729 (T)          729 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.680N         P=0.462N         P=0.681N         P=0.601          P=0.557N                         | 
|POLY 3             |        P=0.564N         P=0.481N         P=0.733N         P=0.528          P=0.524N                         | 
|POLY 1.5           |        P=0.534N         P=0.488N         P=0.745N         P=0.518          P=0.513N                         | 
|POLY 6             |        P=0.604N         P=0.474N         P=0.719N         P=0.539          P=0.541N                         | 
|LOGISTIC REGRESSION|        P=0.613N         P=0.481N         P=0.718N         P=0.555          P=0.534N                         | 
|COCH-ARM / FISHERS |        P=0.492N         P=0.500N         P=0.752N         P=0.500          P=0.500N                         | 
|ORDER RESTRICTED   |        P=0.396N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        3/53 (6%)        0/53 (0%)        0/53 (0%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        0/36.25          3/40.53          0/41.29          0/39.44          0/32.33                          | 
|POLY-3 PERCENT (g) |        0.0%             7.4%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        2/23 (9%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              563              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.264N         P=0.172          (e)              (e)              (e)                              | 
|POLY 3             |        P=0.190N         P=0.139          (e)              (e)              (e)                              | 
|POLY 1.5           |        P=0.196N         P=0.131          (e)              (e)              (e)                              | 
|POLY 6             |        P=0.180N         P=0.149          (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.222N         P=0.134          (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.209N         P=0.121          (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.176N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/53 (2%)        2/53 (4%)        3/53 (6%)        1/53 (2%)                        | 
|POLY-3 RATE (b)    |        0/36.25          1/40.36          2/42.04          3/39.81          1/32.84                          | 
|POLY-3 PERCENT (g) |        0.0%             2.5%             4.8%             7.5%             3.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        1/24 (4%)        2/23 (9%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              626              456              626              575                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.275          P=0.532          P=0.294          P=0.175          P=0.478                          | 
|POLY 3             |        P=0.338          P=0.521          P=0.271          P=0.135          P=0.480                          | 
|POLY 1.5           |        P=0.378          P=0.514          P=0.256          P=0.129          P=0.489                          | 
|POLY 6             |        P=0.284          P=0.531          P=0.289          P=0.144          P=0.467                          | 
|LOGISTIC REGRESSION|        P=0.422          P=0.498          P=0.228          P=0.139          P=0.507                          | 
|COCH-ARM / FISHERS |        P=0.433          P=0.500          P=0.248          P=0.121          P=0.500                          | 
|ORDER RESTRICTED   |        P=0.209          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        18/53 (34%)      19/53 (36%)      24/53 (45%)      20/53 (38%)      19/53 (36%)                      | 
|POLY-3 RATE (b)    |        18/39.90         19/42.18         24/45.53         20/42.19         19/37.72                         | 
|POLY-3 PERCENT (g) |        45.1%            45.1%            52.7%            47.4%            50.4%                            | 
|TERMINAL (d)       |        9/16 (56%)       12/23 (52%)      12/24 (50%)      9/23 (39%)       6/8 (75%)                        | 
|FIRST INCIDENCE    |        454              548              456              619              387                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.031 *        P=0.271N         P=0.545N         P=0.357N         P=0.087                          | 
|POLY 3             |        P=0.386          P=0.588N         P=0.309          P=0.506          P=0.402                          | 
|POLY 1.5           |        P=0.465          P=0.565          P=0.233          P=0.473          P=0.449                          | 
|POLY 6             |        P=0.279          P=0.573N         P=0.405          P=0.557          P=0.313                          | 
|LOGISTIC REGRESSION|        P=0.341          P=0.523N         P=0.247          P=0.543          P=0.384                          | 
|COCH-ARM / FISHERS |        P=0.507N         P=0.500          P=0.160          P=0.420          P=0.500                          | 
|ORDER RESTRICTED   |        P=0.553          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/53 (0%)        0/53 (0%)        1/53 (2%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        2/36.83          0/39.99          0/41.29          1/39.92          0/32.33                          | 
|POLY-3 PERCENT (g) |        5.4%             0.0%             0.0%             2.5%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        631              ---              ---              585              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.328N         P=0.205N         P=0.194N         P=0.442N         P=0.287N                         | 
|POLY 3             |        P=0.326N         P=0.219N         P=0.212N         P=0.472N         P=0.266N                         | 
|POLY 1.5           |        P=0.313N         P=0.225N         P=0.223N         P=0.482N         P=0.253N                         | 
|POLY 6             |        P=0.339N         P=0.213N         P=0.202N         P=0.461N         P=0.290N                         | 
|LOGISTIC REGRESSION|        P=0.290N         P=0.229N         P=0.229N         P=0.500N         P=0.254N                         | 
|COCH-ARM / FISHERS |        P=0.291N         P=0.248N         P=0.248N         P=0.500N         P=0.248N                         | 
|ORDER RESTRICTED   |        P=0.063N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/53 (4%)        1/53 (2%)        3/53 (6%)        3/53 (6%)                        | 
|POLY-3 RATE (b)    |        0/36.25          2/39.99          1/41.29          3/39.55          3/32.86                          | 
|POLY-3 PERCENT (g) |        0.0%             5.0%             2.4%             7.6%             9.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        2/23 (9%)        1/24 (4%)        2/23 (9%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        ---              729 (T)          729 (T)          702              589                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.011 *        P=0.320          P=0.581          P=0.177          P=0.062                          | 
|POLY 3             |        P=0.070          P=0.259          P=0.526          P=0.134          P=0.100                          | 
|POLY 1.5           |        P=0.083          P=0.251          P=0.514          P=0.128          P=0.108                          | 
|POLY 6             |        P=0.056          P=0.269          P=0.539          P=0.141          P=0.089                          | 
|LOGISTIC REGRESSION|        P=0.036 *        P=0.320          P=0.581          P=0.150          P=0.092                          | 
|COCH-ARM / FISHERS |        P=0.104          P=0.248          P=0.500          P=0.121          P=0.121                          | 
|ORDER RESTRICTED   |        P=0.065          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        43/52 (83%)      48/53 (91%)      42/53 (79%)      44/53 (83%)      42/51 (82%)                      | 
|POLY-3 RATE (b)    |        43/48.87         48/50.64         42/49.59         44/48.96         42/46.70                         | 
|POLY-3 PERCENT (g) |        88.0%            94.8%            84.7%            89.9%            89.9%                            | 
|TERMINAL (d)       |        15/16 (94%)      22/23 (96%)      21/24 (88%)      21/23 (91%)      7/8 (88%)                        | 
|FIRST INCIDENCE    |        176              227              263              276              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.012 *        P=0.278N         P=0.052N         P=0.139N         P=0.079                          | 
|POLY 3             |        P=0.561          P=0.166          P=0.422N         P=0.511          P=0.511                          | 
|POLY 1.5           |        P=0.488N         P=0.157          P=0.471N         P=0.529          P=0.546                          | 
|POLY 6             |        P=0.504          P=0.216          P=0.365N         P=0.521          P=0.511                          | 
|LOGISTIC REGRESSION|        P=0.432N         P=0.215          P=0.381N         P=0.577N         P=0.594N                         | 
|COCH-ARM / FISHERS |        P=0.382N         P=0.184          P=0.421N         P=0.584          P=0.584N                         | 
|ORDER RESTRICTED   |        P=0.484N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        45/52 (87%)      50/53 (94%)      52/53 (98%)      47/53 (89%)      46/51 (90%)                      | 
|POLY-3 RATE (b)    |        45/49.91         50/50.93         52/52.25         47/50.57         46/50.20                         | 
|POLY-3 PERCENT (g) |        90.2%            98.2%            99.5%            92.9%            91.6%                            | 
|TERMINAL (d)       |        14/16 (88%)      23/23 (100%)     24/24 (100%)     21/23 (91%)      7/8 (88%)                        | 
|FIRST INCIDENCE    |        176              227              46               315              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.009 **       P=0.269N         P=0.259N         P=0.176N         P=0.061                          | 
|POLY 3             |        P=0.243N         P=0.074          P=0.029 *        P=0.440          P=0.538                          | 
|POLY 1.5           |        P=0.296N         P=0.095          P=0.028 *        P=0.443          P=0.498                          | 
|POLY 6             |        P=0.217N         P=0.065          P=0.036 *        P=0.455          P=0.567                          | 
|LOGISTIC REGRESSION|        P=0.464N         P=0.192          P=0.035 *        P=0.528          P=0.417                          | 
|COCH-ARM / FISHERS |        P=0.436N         P=0.152          P=0.028 *        P=0.485          P=0.394                          | 
|ORDER RESTRICTED   |        P=0.155          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/52 (2%)        2/53 (4%)        3/53 (6%)        2/53 (4%)        3/51 (6%)                        | 
|POLY-3 RATE (b)    |        1/35.79          2/41.76          3/42.75          2/40.85          3/33.16                          | 
|POLY-3 PERCENT (g) |        2.8%             4.8%             7.0%             4.9%             9.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        727              350              46               465              409                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.204          P=0.541          P=0.395          P=0.557          P=0.188                          | 
|POLY 3             |        P=0.244          P=0.554          P=0.371          P=0.546          P=0.276                          | 
|POLY 1.5           |        P=0.268          P=0.538          P=0.348          P=0.531          P=0.291                          | 
|POLY 6             |        P=0.212          P=0.570          P=0.399          P=0.563          P=0.250                          | 
|LOGISTIC REGRESSION|        P=0.300          P=0.408          P=0.285          P=0.475          P=0.283                          | 
|COCH-ARM / FISHERS |        P=0.291          P=0.507          P=0.316          P=0.507          P=0.301                          | 
|ORDER RESTRICTED   |        P=0.249          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Red Pulp                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        1/53 (2%)        3/53 (6%)        0/53 (0%)        0/51 (0%)                        | 
|POLY-3 RATE (b)    |        0/35.78          1/40.88          3/41.75          0/39.44          0/32.27                          | 
|POLY-3 PERCENT (g) |        0.0%             2.5%             7.2%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        1/24 (4%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              350              652              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.365N         P=0.508          P=0.190          (e)              (e)                              | 
|POLY 3             |        P=0.301N         P=0.527          P=0.148          (e)              (e)                              | 
|POLY 1.5           |        P=0.295N         P=0.519          P=0.136          (e)              (e)                              | 
|POLY 6             |        P=0.311N         P=0.535          P=0.163          (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.289N         P=0.381          P=0.145          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.295N         P=0.505          P=0.125          (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.307N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        2/53 (4%)        2/53 (4%)        0/52 (0%)                        | 
|POLY-3 RATE (b)    |        0/36.25          0/39.99          2/41.69          2/40.01          0/32.33                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             4.8%             5.0%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              639              619              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.599          (e)              P=0.295          P=0.266          (e)                              | 
|POLY 3             |        P=0.592          (e)              P=0.269          P=0.259          (e)                              | 
|POLY 1.5           |        P=0.635          (e)              P=0.255          P=0.251          (e)                              | 
|POLY 6             |        P=0.522          (e)              P=0.287          P=0.271          (e)                              | 
|LOGISTIC REGRESSION|        P=0.645N         (e)              P=0.256          P=0.244          (e)                              | 
|COCH-ARM / FISHERS |        P=0.620N         (e)              P=0.248          P=0.248          (e)                              | 
|ORDER RESTRICTED   |        P=0.289          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/53 (9%)        1/53 (2%)        4/53 (8%)        9/53 (17%)       6/52 (12%)                       | 
|POLY-3 RATE (b)    |        5/37.95          1/40.96          4/42.67          9/41.67          6/34.04                          | 
|POLY-3 PERCENT (g) |        13.2%            2.4%             9.4%             21.6%            17.6%                            | 
|TERMINAL (d)       |        1/16 (6%)        0/23 (0%)        1/24 (4%)        3/23 (13%)       1/8 (13%)                        | 
|FIRST INCIDENCE    |        484              227              203              505              434                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.030 *        P=0.081N         P=0.377N         P=0.325          P=0.322                          | 
|POLY 3             |        P=0.056          P=0.083N         P=0.426N         P=0.243          P=0.422                          | 
|POLY 1.5           |        P=0.078          P=0.088N         P=0.455N         P=0.224          P=0.457                          | 
|POLY 6             |        P=0.036 *        P=0.079N         P=0.399N         P=0.270          P=0.368                          | 
|LOGISTIC REGRESSION|        P=0.127          P=0.130N         P=0.523N         P=0.207          P=0.466                          | 
|COCH-ARM / FISHERS |        P=0.117          P=0.103N         P=0.500N         P=0.195          P=0.486                          | 
|ORDER RESTRICTED   |        P=0.103          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/53 (0%)        2/53 (4%)        1/53 (2%)        3/52 (6%)                        | 
|POLY-3 RATE (b)    |        2/37.31          0/39.99          2/42.34          1/39.83          3/34.02                          | 
|POLY-3 PERCENT (g) |        5.4%             0.0%             4.7%             2.5%             8.8%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        484              ---              203              619              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.155          P=0.220N         P=0.642N         P=0.470N         P=0.459                          | 
|POLY 3             |        P=0.175          P=0.221N         P=0.648N         P=0.477N         P=0.457                          | 
|POLY 1.5           |        P=0.190          P=0.226N         P=0.666N         P=0.485N         P=0.478                          | 
|POLY 6             |        P=0.157          P=0.216N         P=0.629N         P=0.468N         P=0.425                          | 
|LOGISTIC REGRESSION|        P=0.234          P=0.264N         P=0.672          P=0.525N         P=0.500                          | 
|COCH-ARM / FISHERS |        P=0.209          P=0.248N         P=0.691N         P=0.500N         P=0.491                          | 
|ORDER RESTRICTED   |        P=0.168          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        0/53 (0%)        4/53 (8%)        2/53 (4%)        0/52 (0%)                        | 
|POLY-3 RATE (b)    |        1/36.53          0/39.99          4/43.15          2/39.67          0/32.33                          | 
|POLY-3 PERCENT (g) |        2.7%             0.0%             9.3%             5.0%             0.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        1/24 (4%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        655              ---              263              668              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.430N         P=0.475N         P=0.250          P=0.595          P=0.553N                         | 
|POLY 3             |        P=0.393N         P=0.482N         P=0.233          P=0.529          P=0.524N                         | 
|POLY 1.5           |        P=0.362N         P=0.488N         P=0.209          P=0.518          P=0.513N                         | 
|POLY 6             |        P=0.440N         P=0.475N         P=0.259          P=0.542          P=0.542N                         | 
|LOGISTIC REGRESSION|        P=0.320N         P=0.491N         P=0.160          P=0.531          P=0.519N                         | 
|COCH-ARM / FISHERS |        P=0.331N         P=0.500N         P=0.181          P=0.500          P=0.505N                         | 
|ORDER RESTRICTED   |        P=0.307N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 53      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        0/53 (0%)        2/53 (4%)        1/53 (2%)        2/52 (4%)                        | 
|POLY-3 RATE (b)    |        3/37.58          0/39.99          2/42.59          1/39.62          2/33.44                          | 
|POLY-3 PERCENT (g) |        8.0%             0.0%             4.7%             2.5%             6.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        484              ---              203              682              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.509          P=0.106N         P=0.436N         P=0.264N         P=0.564N                         | 
|POLY 3             |        P=0.522          P=0.107N         P=0.443N         P=0.285N         P=0.554N                         | 
|POLY 1.5           |        P=0.547          P=0.111N         P=0.465N         P=0.292N         P=0.528N                         | 
|POLY 6             |        P=0.489          P=0.104N         P=0.421N         P=0.279N         P=0.595N                         | 
|LOGISTIC REGRESSION|        P=0.605          P=0.131N         P=0.534N         P=0.312N         P=0.498N                         | 
|COCH-ARM / FISHERS |        P=0.579          P=0.121N         P=0.500N         P=0.309N         P=0.509N                         | 
|ORDER RESTRICTED   |        P=0.288N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Artery                                                                                                     | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        2/53 (4%)        1/52 (2%)                        | 
|POLY-3 RATE (b)    |        0/36.25          0/39.99          0/41.29          2/39.44          1/32.33                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.1%             3.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        2/23 (9%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              729 (T)          729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.041 *        (e)              (e)              P=0.320          P=0.362                          | 
|POLY 3             |        P=0.118          (e)              (e)              P=0.256          P=0.477                          | 
|POLY 1.5           |        P=0.140          (e)              (e)              P=0.249          P=0.487                          | 
|POLY 6             |        P=0.090          (e)              (e)              P=0.264          P=0.461                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.320          P=0.362                          | 
|COCH-ARM / FISHERS |        P=0.168          (e)              (e)              P=0.248          P=0.495                          | 
|ORDER RESTRICTED   |        P=0.153          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 54      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        4/53 (8%)        3/53 (6%)        3/53 (6%)        1/52 (2%)                        | 
|POLY-3 RATE (b)    |        2/36.53          4/40.36          3/42.24          3/40.15          1/32.69                          | 
|POLY-3 PERCENT (g) |        5.5%             9.9%             7.1%             7.5%             3.1%                             | 
|TERMINAL (d)       |        1/16 (6%)        3/23 (13%)       2/24 (8%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        655              626              263              585              631                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.418N         P=0.477          P=0.627          P=0.615          P=0.627N                         | 
|POLY 3             |        P=0.292N         P=0.383          P=0.566          P=0.543          P=0.539N                         | 
|POLY 1.5           |        P=0.266N         P=0.367          P=0.539          P=0.527          P=0.521N                         | 
|POLY 6             |        P=0.327N         P=0.403          P=0.594          P=0.564          P=0.566N                         | 
|LOGISTIC REGRESSION|        P=0.259N         P=0.400          P=0.494          P=0.532          P=0.548N                         | 
|COCH-ARM / FISHERS |        P=0.239N         P=0.339          P=0.500          P=0.500          P=0.507N                         | 
|ORDER RESTRICTED   |        P=0.400N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Artery                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        2/52 (4%)                        | 
|POLY-3 RATE (b)    |        0/36.25          0/39.99          0/41.29          0/39.44          2/33.05                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             6.1%                             | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              497                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       (e)              (e)              (e)              P=0.181                          | 
|POLY 3             |        P=0.017 *        (e)              (e)              (e)              P=0.216                          | 
|POLY 1.5           |        P=0.018 *        (e)              (e)              (e)              P=0.225                          | 
|POLY 6             |        P=0.016 *        (e)              (e)              (e)              P=0.201                          | 
|LOGISTIC REGRESSION|        P=0.022 *        (e)              (e)              (e)              P=0.233                          | 
|COCH-ARM / FISHERS |        P=0.020 *        (e)              (e)              (e)              P=0.243                          | 
|ORDER RESTRICTED   |        P=0.012 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 55      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        32/52 (62%)      43/48 (90%)      45/50 (90%)      50/53 (94%)      48/50 (96%)                      | 
|POLY-3 RATE (b)    |        32/43.70         43/46.85         45/46.72         50/51.69         48/48.79                         | 
|POLY-3 PERCENT (g) |        73.2%            91.8%            96.3%            96.7%            98.4%                            | 
|TERMINAL (d)       |        10/16 (63%)      18/21 (86%)      21/22 (96%)      23/23 (100%)     7/7 (100%)                       | 
|FIRST INCIDENCE    |        387              227              203              276              287                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.345          P=0.374          P=0.147          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.012 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.005 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.027 *        P=0.002 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/52 (4%)        0/48 (0%)        0/50 (0%)        0/53 (0%)        0/50 (0%)                        | 
|POLY-3 RATE (b)    |        2/35.84          0/35.89          0/38.91          0/39.44          0/29.87                          | 
|POLY-3 PERCENT (g) |        5.6%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        1/16 (6%)        0/21 (0%)        0/22 (0%)        0/23 (0%)        0/7 (0%)                         | 
|FIRST INCIDENCE    |        669              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.215N         P=0.188N         P=0.174N         P=0.173N         P=0.350N                         | 
|POLY 3             |        P=0.185N         P=0.236N         P=0.219N         P=0.216N         P=0.279N                         | 
|POLY 1.5           |        P=0.188N         P=0.242N         P=0.230N         P=0.222N         P=0.264N                         | 
|POLY 6             |        P=0.173N         P=0.230N         P=0.207N         P=0.209N         P=0.304N                         | 
|LOGISTIC REGRESSION|        P=0.204N         P=0.229N         P=0.207N         P=0.208N         P=0.308N                         | 
|COCH-ARM / FISHERS |        P=0.189N         P=0.268N         P=0.257N         P=0.243N         P=0.257N                         | 
|ORDER RESTRICTED   |        P=0.027N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 56      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        24/53 (45%)      24/53 (45%)      20/51 (39%)      18/52 (35%)      14/51 (27%)                      | 
|POLY-3 RATE (b)    |        24/40.35         24/42.46         20/42.10         18/42.50         14/34.91                         | 
|POLY-3 PERCENT (g) |        59.5%            56.5%            47.5%            42.4%            40.1%                            | 
|TERMINAL (d)       |        12/16 (75%)      15/23 (65%)      11/24 (46%)      9/23 (39%)       4/8 (50%)                        | 
|FIRST INCIDENCE    |        454              540              540              505              562                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.439N         P=0.143N         P=0.032N*        P=0.029N*        P=0.430N                         | 
|POLY 3             |        P=0.034N*        P=0.479N         P=0.181N         P=0.079N         P=0.060N                         | 
|POLY 1.5           |        P=0.023N*        P=0.510N         P=0.245N         P=0.108N         P=0.046N*                        | 
|POLY 6             |        P=0.057N         P=0.434N         P=0.120N         P=0.052N         P=0.092N                         | 
|LOGISTIC REGRESSION|        P=0.053N         P=0.372N         P=0.126N         P=0.089N         P=0.074N                         | 
|COCH-ARM / FISHERS |        P=0.018N*        P=0.577N         P=0.335N         P=0.180N         P=0.046N*                        | 
|ORDER RESTRICTED   |        P=0.067N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        13/53 (25%)      12/51 (24%)      18/52 (35%)      23/51 (45%)                      | 
|POLY-3 RATE (b)    |        4/37.36          13/43.35         12/44.05         18/42.44         23/41.48                         | 
|POLY-3 PERCENT (g) |        10.7%            30.0%            27.2%            42.4%            55.5%                            | 
|TERMINAL (d)       |        2/16 (13%)       4/23 (17%)       4/24 (17%)       10/23 (44%)      6/8 (75%)                        | 
|FIRST INCIDENCE    |        454              416              203              333              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.063          P=0.101          P=0.009 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.030 *        P=0.054          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.023 *        P=0.037 *        P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.042 *        P=0.081          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.019 *        P=0.021 *        P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.016 *        P=0.022 *        P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 57      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        23/24 (96%)      21/23 (91%)      22/27 (81%)      34/37 (92%)      30/30 (100%)                     | 
|POLY-3 RATE (b)    |        23/23.65         21/22.74         22/26.16         34/35.13         30/30.00                         | 
|POLY-3 PERCENT (g) |        97.3%            92.4%            84.1%            96.8%            100.0%                           | 
|TERMINAL (d)       |        8/8 (100%)       9/10 (90%)       11/13 (85%)      16/16 (100%)     3/3 (100%)                       | 
|FIRST INCIDENCE    |        218              362              529              333              339                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.177N         P=0.081N         P=0.540          P=0.010 *                        | 
|POLY 3             |        P=0.092          P=0.461N         P=0.120N         P=0.811N         P=0.664                          | 
|POLY 1.5           |        P=0.093          P=0.472N         P=0.122N         P=0.674N         P=0.551                          | 
|POLY 6             |        P=0.105          P=0.447N         P=0.116N         P=0.945          P=0.895                          | 
|LOGISTIC REGRESSION|        P=0.101          P=0.514N         P=0.137N         P=0.381N         P=0.462                          | 
|COCH-ARM / FISHERS |        P=0.114          P=0.484N         P=0.124N         P=0.484N         P=0.444                          | 
|ORDER RESTRICTED   |        P=0.093          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        12/52 (23%)      3/52 (6%)        4/53 (8%)        8/53 (15%)       5/50 (10%)                       | 
|POLY-3 RATE (b)    |        12/38.36         3/40.57          4/42.04          8/40.61          5/32.54                          | 
|POLY-3 PERCENT (g) |        31.3%            7.4%             9.5%             19.7%            15.4%                            | 
|TERMINAL (d)       |        3/16 (19%)       1/23 (4%)        1/24 (4%)        6/23 (26%)       1/8 (13%)                        | 
|FIRST INCIDENCE    |        540              540              621              276              434                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.530          P=0.005N**       P=0.009N**       P=0.096N         P=0.234N                         | 
|POLY 3             |        P=0.393N         P=0.006N**       P=0.013N*        P=0.173N         P=0.094N                         | 
|POLY 1.5           |        P=0.335N         P=0.007N**       P=0.016N*        P=0.180N         P=0.073N                         | 
|POLY 6             |        P=0.474N         P=0.006N**       P=0.011N*        P=0.181N         P=0.150N                         | 
|LOGISTIC REGRESSION|        P=0.330N         P=0.008N**       P=0.016N*        P=0.174N         P=0.088N                         | 
|COCH-ARM / FISHERS |        P=0.278N         P=0.012N*        P=0.025N*        P=0.214N         P=0.065N                         | 
|ORDER RESTRICTED   |        P=0.028N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 58      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder: Transitional Epithelium                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        0/52 (0%)        1/53 (2%)        3/53 (6%)        4/50 (8%)                        | 
|POLY-3 RATE (b)    |        0/35.78          0/39.75          1/41.29          3/40.38          4/31.75                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.4%             7.4%             12.6%                            | 
|TERMINAL (d)       |        0/16 (0%)        0/23 (0%)        1/24 (4%)        2/23 (9%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        ---              ---              729 (T)          276              715                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.581          P=0.170          P=0.019 *                        | 
|POLY 3             |        P=0.002 **       (e)              P=0.528          P=0.141          P=0.044 *                        | 
|POLY 1.5           |        P=0.003 **       (e)              P=0.518          P=0.135          P=0.050                          | 
|POLY 6             |        P=0.002 **       (e)              P=0.540          P=0.148          P=0.036 *                        | 
|LOGISTIC REGRESSION|        P=0.003 **       (e)              P=0.581          P=0.110          P=0.019 *                        | 
|COCH-ARM / FISHERS |        P=0.005 **       (e)              P=0.505          P=0.125          P=0.054                          | 
|ORDER RESTRICTED   |        P=0.010 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Adenomyosis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/52 (0%)        1/53 (2%)        1/53 (2%)        2/53 (4%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        0/35.78          1/39.99          1/41.91          2/39.85          1/32.85                          | 
|POLY-3 PERCENT (g) |        0.0%             2.5%             2.4%             5.0%             3.0%                             | 
|TERMINAL (d)       |        0/16 (0%)        1/23 (4%)        0/24 (0%)        0/23 (0%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              729 (T)          526              668              546                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.305          P=0.572          P=0.531          P=0.289          P=0.500                          | 
|POLY 3             |        P=0.340          P=0.522          P=0.531          P=0.261          P=0.483                          | 
|POLY 1.5           |        P=0.370          P=0.516          P=0.519          P=0.254          P=0.491                          | 
|POLY 6             |        P=0.296          P=0.529          P=0.545          P=0.271          P=0.469                          | 
|LOGISTIC REGRESSION|        P=0.396          P=0.572          P=0.491          P=0.256          P=0.494                          | 
|COCH-ARM / FISHERS |        P=0.396          P=0.505          P=0.505          P=0.252          P=0.495                          | 
|ORDER RESTRICTED   |        P=0.269          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 59      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/52 (12%)       5/53 (9%)        9/53 (17%)       13/53 (25%)      6/51 (12%)                       | 
|POLY-3 RATE (b)    |        6/37.08          5/41.55          9/42.08          13/42.94         6/35.30                          | 
|POLY-3 PERCENT (g) |        16.2%            12.0%            21.4%            30.3%            17.0%                            | 
|TERMINAL (d)       |        2/16 (13%)       1/23 (4%)        3/24 (13%)       4/23 (17%)       0/8 (0%)                         | 
|FIRST INCIDENCE    |        526              498              669              333              434                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.143          P=0.357N         P=0.545          P=0.175          P=0.452                          | 
|POLY 3             |        P=0.314          P=0.419N         P=0.381          P=0.109          P=0.589                          | 
|POLY 1.5           |        P=0.367          P=0.442N         P=0.345          P=0.092          P=0.606                          | 
|POLY 6             |        P=0.239          P=0.396N         P=0.421          P=0.132          P=0.552                          | 
|LOGISTIC REGRESSION|        P=0.389          P=0.464N         P=0.402          P=0.078          P=0.605                          | 
|COCH-ARM / FISHERS |        P=0.414          P=0.486N         P=0.303          P=0.069          P=0.606                          | 
|ORDER RESTRICTED   |        P=0.242          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/52 (2%)        1/53 (2%)        1/53 (2%)        1/53 (2%)        3/51 (6%)                        | 
|POLY-3 RATE (b)    |        1/35.78          1/39.99          1/41.29          1/39.44          3/33.64                          | 
|POLY-3 PERCENT (g) |        2.8%             2.5%             2.4%             2.5%             8.9%                             | 
|TERMINAL (d)       |        1/16 (6%)        1/23 (4%)        1/24 (4%)        1/23 (4%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        729 (T)          729 (T)          729 (T)          729 (T)          312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.037 *        P=0.680N         P=0.670N         P=0.680N         P=0.210                          | 
|POLY 3             |        P=0.112          P=0.736N         P=0.728N         P=0.739N         P=0.281                          | 
|POLY 1.5           |        P=0.121          P=0.743N         P=0.741N         P=0.745N         P=0.294                          | 
|POLY 6             |        P=0.100          P=0.728N         P=0.714N         P=0.732N         P=0.259                          | 
|LOGISTIC REGRESSION|        P=0.117          P=0.680N         P=0.670N         P=0.680N         P=0.301                          | 
|COCH-ARM / FISHERS |        P=0.129          P=0.748N         P=0.748N         P=0.748N         P=0.301                          | 
|ORDER RESTRICTED   |        P=0.145          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  09/29/03                           EXPERIMENT: 96007 TEST: 04                                            Page 60      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -   TOXIC EQUIVALENCY FACTOR EVALUATION (DIOX         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        21/52 (40%)      32/53 (60%)      32/53 (60%)      35/53 (66%)      30/51 (59%)                      | 
|POLY-3 RATE (b)    |        21/42.47         32/47.25         32/47.49         35/48.38         30/43.09                         | 
|POLY-3 PERCENT (g) |        49.4%            67.7%            67.4%            72.3%            69.6%                            | 
|TERMINAL (d)       |        6/16 (38%)       14/23 (61%)      16/24 (67%)      16/23 (70%)      5/8 (63%)                        | 
|FIRST INCIDENCE    |        387              416              263              276              312                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.264          P=0.342          P=0.145          P=0.011 *                        | 
|POLY 3             |        P=0.093          P=0.054          P=0.058          P=0.016 *        P=0.036 *                        | 
|POLY 1.5           |        P=0.128          P=0.043 *        P=0.043 *        P=0.012 *        P=0.047 *                        | 
|POLY 6             |        P=0.048 *        P=0.070          P=0.073          P=0.020 *        P=0.020 *                        | 
|LOGISTIC REGRESSION|        P=0.110          P=0.041 *        P=0.041 *        P=0.008 **       P=0.046 *                        | 
|COCH-ARM / FISHERS |        P=0.129          P=0.032 *        P=0.032 *        P=0.007 **       P=0.047 *                        | 
|ORDER RESTRICTED   |        P=0.022 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX         TERT.MIX                         | 
|                   |        CONTROL          TEQ=10           TEQ=22           TEQ=46           TEQ=100                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        37/52 (71%)      35/53 (66%)      34/53 (64%)      33/53 (62%)      23/51 (45%)                      | 
|POLY-3 RATE (b)    |        37/45.66         35/46.77         34/46.84         33/46.63         23/39.74                         | 
|POLY-3 PERCENT (g) |        81.0%            74.8%            72.6%            70.8%            57.9%                            | 
|TERMINAL (d)       |        14/16 (88%)      16/23 (70%)      20/24 (83%)      16/23 (70%)      5/8 (63%)                        | 
|FIRST INCIDENCE    |        176              416              263              276              339                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.513N         P=0.085N         P=0.029N*        P=0.052N         P=0.360N                         | 
|POLY 3             |        P=0.008N**       P=0.306N         P=0.219N         P=0.163N         P=0.009N**                       | 
|POLY 1.5           |        P=0.004N**       P=0.334N         P=0.261N         P=0.182N         P=0.006N**                       | 
|POLY 6             |        P=0.026N*        P=0.247N         P=0.177N         P=0.129N         P=0.019N*                        | 
|LOGISTIC REGRESSION|        P=0.005N**       P=0.264N         P=0.209N         P=0.176N         P=0.007N**                       | 
|COCH-ARM / FISHERS |        P=0.003N**       P=0.362N         P=0.289N         P=0.224N         P=0.006N**                       | 
|ORDER RESTRICTED   |        P=0.009N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
                                                                                                                                   
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).