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TDMS Study 96007-04 Pathology Tables

NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/29/03
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 12:14:44

                                                          FINAL#4/RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFDIOXINMIX

       Lock Date:  09/12/01

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/29/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 12:14:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98           98           98           98                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                26           25           22           25           33                        
    Natural Death                                     11            5            6            4           10                        
    Dosing Accident                                                              1            1            2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                16           23           24           23            8                        
                                                                                                                                    
  Animals Examined Microscopically                    53           53           53           53           53                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (53)         (53)         (53)         (53)         (53)                      
      Muscularis, Inflammation                                      2 [1.0]      1 [2.0]      1 [1.0]                               
   Intestine Large, Colon                             (53)         (52)         (53)         (53)         (51)                      
      Parasite Metazoan                                                          1                                                  
   Intestine Large, Rectum                            (52)         (53)         (53)         (53)         (52)                      
      Parasite Metazoan                                2            4            5            1                                     
      Artery, Inflammation, Chronic Active                                                    2 [2.5]      3 [3.0]                  
      Serosa, Inflammation                                                                                 1 [3.0]                  
   Intestine Large, Cecum                             (51)         (53)         (53)         (53)         (51)                      
      Artery, Inflammation, Chronic Active                                                                 1 [2.0]                  
   Intestine Small, Duodenum                          (52)         (53)         (53)         (53)         (52)                      
      Serosa, Inflammation, Chronic Active                                                                 1 [3.0]                  
   Liver                                              (53)         (53)         (53)         (53)         (51)                      
      Angiectasis                                      3 [1.7]      2 [1.5]                                3 [1.0]                  
      Basophilic Focus                                 9           14           10            5            8                        
      Basophilic Focus, Multiple                      15           12            3            7            8                        
      Cholangiofibrosis                                             2 [1.0]      3 [2.0]      4 [2.5]     17 [2.3]                  
      Clear Cell Focus                                              1            1                                                  
      Clear Cell Focus, Multiple                       1                                      1                                     
      Degeneration, Cystic                             1 [1.0]                                1 [1.0]      2 [1.0]                  
      Eosinophilic Focus                               4            2            5            5                                     
      Eosinophilic Focus, Multiple                     1            7            6           15           19                        
      Fatty Change, Diffuse                            3 [2.3]      5 [1.0]     14 [1.0]     34 [1.1]     36 [1.3]                  
      Fatty Change, Focal                              3 [1.3]      4 [1.5]      7 [1.6]      2 [1.5]      1 [1.0]                  
      Hematopoietic Cell Proliferation                16 [1.1]     18 [1.1]     19 [1.1]      8 [1.0]      9 [1.1]                  
      Hepatodiaphragmatic Nodule                                                 1                                                  
      Hyperplasia, Nodular                                          1            3           11           38                        
      Inflammation                                    36 [1.1]     50 [1.1]     45 [1.2]     50 [1.3]     50 [1.3]                  
      Karyomegaly                                                                             1 [3.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/29/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 12:14:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mixed Cell Focus                                 4            5            5            1                                     
      Mixed Cell Focus, Multiple                      17           27           30           35           17                        
      Necrosis                                         3 [1.7]      1 [2.0]      9 [2.2]      3 [1.7]     15 [2.2]                  
      Pigmentation                                     4 [1.5]     35 [1.3]     41 [1.2]     48 [1.9]     51 [2.2]                  
      Toxic Hepatopathy                                             5 [1.0]     14 [1.0]     38 [1.6]     47 [3.1]                  
      Bile Duct, Cyst                                  1 [3.0]      3 [2.7]      3 [2.3]      4 [2.3]      9 [2.0]                  
      Bile Duct, Dilatation                            1 [1.0]                                             1 [3.0]                  
      Bile Duct, Fibrosis                              3 [1.7]      2 [1.0]      1 [1.0]      5 [1.4]      1 [2.0]                  
      Bile Duct, Hyperplasia                           2 [1.5]      3 [1.3]      5 [1.4]     25 [1.4]     42 [1.9]                  
      Centrilobular, Degeneration                      3 [1.7]      2 [2.0]      1 [3.0]      1 [2.0]      6 [2.2]                  
      Centrilobular, Fibrosis                                                                              1 [1.0]                  
      Hepatocyte, Hypertrophy                          1 [1.0]     27 [1.1]     34 [1.2]     46 [1.5]     50 [3.0]                  
      Hepatocyte, Multinucleated                                   12 [1.0]     10 [1.2]     39 [1.5]     51 [2.1]                  
      Oval Cell, Hyperplasia                                        1 [1.0]      1 [1.0]     26 [1.4]     42 [2.2]                  
      Portal, Fibrosis                                                                                    11 [1.9]                  
      Serosa, Fibrosis                                                                                     1 [2.0]                  
      Serosa, Inflammation, Chronic                    1 [2.0]                                                                      
   Mesentery                                                       (1)          (2)          (6)          (8)                       
      Inflammation, Chronic Active                                                                         2 [3.0]                  
      Necrosis                                                                   1 [3.0]                   1 [4.0]                  
      Artery, Inflammation, Chronic Active                          1 [4.0]                   3 [3.7]      6 [3.7]                  
      Fat, Necrosis                                                              1 [3.0]      2 [3.0]                               
   Oral Mucosa                                        (10)         (18)         (19)         (29)         (31)                      
      Gingival, Hyperplasia, Squamous                  8 [1.5]     17 [1.5]     18 [1.4]     26 [1.6]     30 [1.6]                  
   Pancreas                                           (52)         (53)         (53)         (53)         (51)                      
      Degeneration                                     1 [2.0]                                                                      
      Inflammation, Chronic Active                     3 [1.7]      1 [3.0]      6 [1.3]      7 [1.7]     16 [1.8]                  
      Inflammation, Granulomatous                                                             1 [2.0]                               
      Acinus, Atrophy                                  3 [1.3]      2 [1.0]      7 [1.7]      7 [1.7]     20 [2.0]                  
      Acinus, Hyperplasia                              2 [1.5]                   1 [2.0]                                            
      Acinus, Vacuolization Cytoplasmic                1 [1.0]                   3 [1.3]     15 [1.0]     30 [1.1]                  
      Artery, Inflammation, Chronic Active                          6 [2.2]      3 [1.7]      8 [2.6]     14 [2.9]                  
      Duct, Cyst                                                                 1 [2.0]                                            
      Duct, Dilatation                                                                                     5 [3.0]                  
      Duct, Inflammation, Chronic Active                                                                   2 [3.5]                  
   Salivary Glands                                    (53)         (53)         (53)         (53)         (53)                      
      Atrophy                                          1 [3.0]                                                                      
      Inflammation                                     2 [2.0]                                1 [3.0]                               
      Mineralization                                                                          1 [2.0]                               
   Stomach, Forestomach                               (53)         (53)         (53)         (53)         (52)                      
      Cyst                                                                                    1 [3.0]      1 [3.0]                  
      Diverticulum                                                                            1                                     
      Edema                                            1 [3.0]                   1 [3.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/29/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 12:14:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Erosion                                                                    1 [1.0]                                            
      Hyperkeratosis                                                             2 [2.5]      2 [2.0]                               
      Hyperplasia, Squamous                            5 [2.4]      1 [2.0]      4 [2.3]      9 [1.7]      6 [2.5]                  
      Inflammation                                     2 [2.5]                   2 [2.5]      1 [3.0]      3 [1.7]                  
      Mineralization                                   1 [2.0]                   4 [1.5]      2 [1.0]                               
      Ulcer                                            3 [3.0]                   2 [2.5]      1 [2.0]      2 [2.0]                  
      Artery, Inflammation, Chronic Active                                                    2 [2.5]      1 [3.0]                  
   Stomach, Glandular                                 (53)         (53)         (53)         (53)         (52)                      
      Erosion                                          1 [2.0]                                                                      
      Mineralization                                   2 [2.0]      4 [1.5]      3 [1.3]      3 [1.7]      1 [2.0]                  
      Artery, Inflammation, Chronic Active                                                                 2 [3.0]                  
   Tongue                                             (1)                                                 (1)                       
      Infiltration Cellular                                                                                1 [3.0]                  
   Tooth                                              (24)         (23)         (27)         (37)         (30)                      
      Peridontal Tissue, Inflammation                 23 [1.1]     21 [1.3]     22 [1.2]     34 [1.3]     30 [1.7]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (53)         (53)         (53)         (52)         (53)                      
      Aorta, Mineralization                                                                   1 [2.0]      3 [2.3]                  
   Heart                                              (53)         (53)         (53)         (52)         (53)                      
      Cardiomyopathy                                  11 [1.0]     26 [1.0]     31 [1.1]     30 [1.1]     32 [1.1]                  
      Inflammation, Suppurative                        1 [3.0]                                             1 [4.0]                  
      Mineralization                                                                          1 [2.0]                               
      Necrosis                                                                                             1 [3.0]                  
      Thrombosis                                       1 [3.0]                                             1 [3.0]                  
      Artery, Degeneration                                                                    1 [2.0]      1 [2.0]                  
      Artery, Inflammation, Chronic Active                                                    1 [2.0]      1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (52)         (53)         (53)         (53)         (51)                      
      Angiectasis                                     15 [1.7]     20 [1.6]     18 [1.5]     17 [1.6]      8 [1.6]                  
      Atrophy                                                       3 [2.3]                               18 [2.7]                  
      Degeneration, Cystic                             9 [2.4]     15 [2.3]     19 [2.3]     25 [2.3]     16 [2.1]                  
      Hematopoietic Cell Proliferation                                           1 [1.0]                   1 [1.0]                  
      Hyperplasia                                     12 [2.5]     26 [2.4]     23 [2.8]     25 [2.6]     21 [2.5]                  
      Hypertrophy                                     44 [2.1]     45 [2.2]     47 [2.4]     46 [2.5]     45 [2.3]                  
      Inflammation                                                                            1 [2.0]                               
      Mineralization                                                1 [3.0]                                1 [3.0]                  
      Necrosis                                         2 [3.0]                   2 [2.5]                   2 [2.5]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/29/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 12:14:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Thrombosis                                                    1 [3.0]                                                         
      Vacuolization Cytoplasmic                        6 [1.2]     13 [1.5]     11 [1.5]      7 [1.7]     15 [1.5]                  
      Capsule, Inflammation                                                                   1 [2.0]      1 [3.0]                  
   Adrenal Medulla                                    (52)         (53)         (53)         (53)         (51)                      
      Hyperplasia                                     10 [2.2]     21 [2.0]     12 [1.8]     15 [1.7]      9 [1.6]                  
   Islets, Pancreatic                                 (52)         (53)         (53)         (53)         (51)                      
      Hyperplasia                                                                1 [2.0]      2 [2.0]                               
   Pituitary Gland                                    (53)         (53)         (53)         (53)         (53)                      
      Angiectasis                                      6 [1.7]                   1 [1.0]      2 [2.5]      3 [2.3]                  
      Cyst                                             1 [2.0]                   1 [2.0]      2 [1.5]                               
      Cytoplasmic Alteration                                        3 [1.3]                                                         
      Hemorrhage                                       1 [2.0]                                                                      
      Vacuolization Cytoplasmic                                     1 [1.0]      2 [1.0]      3 [1.3]      1 [1.0]                  
      Pars Distalis, Hyperplasia                      18 [2.5]     19 [2.3]     24 [2.5]     20 [2.5]     19 [2.1]                  
      Pars Intermedia, Cyst                                                      1 [3.0]                                            
   Thyroid Gland                                      (53)         (53)         (51)         (52)         (51)                      
      C-Cell, Hyperplasia                             24 [2.3]     24 [2.3]     20 [2.1]     18 [2.3]     14 [2.0]                  
      Follicular Cell, Hyperplasia                     1 [1.0]                                                                      
      Follicular Cell, Hypertrophy                     4 [1.5]     13 [1.1]     12 [1.5]     18 [1.7]     23 [1.9]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (51)         (53)         (53)         (51)         (50)                      
      Hyperplasia, Squamous                                                                   1 [2.0]                               
      Inflammation                                    42 [1.7]     40 [1.7]     37 [1.3]     33 [1.3]     29 [1.1]                  
      Duct, Cyst                                      39 [2.3]     41 [2.5]     44 [2.1]     39 [2.3]     44 [2.3]                  
   Ovary                                              (52)         (52)         (53)         (53)         (51)                      
      Atrophy                                         44 [4.0]     44 [4.0]     43 [4.0]     49 [3.9]     40 [4.0]                  
      Cyst                                             8 [2.6]     16 [2.4]     20 [2.3]     14 [2.3]      7 [2.3]                  
      Fibrosis                                                      1 [3.0]                                                         
      Hemorrhage                                                                                           1 [2.0]                  
      Inflammation, Chronic Active                                  2 [3.0]      1 [4.0]      2 [3.5]      5 [3.6]                  
      Artery, Inflammation, Chronic Active                                                                 1 [4.0]                  
   Oviduct                                                         (2)                       (2)          (5)                       
      Cyst                                                          2 [2.0]                                1 [2.0]                  
      Inflammation, Chronic Active                                                            2 [4.0]      4 [4.0]                  
   Uterus                                             (52)         (53)         (53)         (53)         (51)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/29/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 12:14:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Adenomyosis                                                   1 [2.0]      1 [2.0]      2 [2.0]      1 [2.0]                  
      Hemorrhage                                       1 [3.0]                                             1 [2.0]                  
      Inflammation, Chronic Active                     1 [2.0]      1 [3.0]      1 [3.0]      1 [4.0]      3 [3.0]                  
      Inflammation, Suppurative                        6 [1.8]      5 [2.2]      9 [1.8]     13 [1.8]      6 [3.2]                  
      Metaplasia, Squamous                            21 [2.0]     32 [2.2]     32 [2.3]     35 [2.4]     30 [2.4]                  
      Necrosis                                                                                             1 [4.0]                  
      Thrombosis                                                                              1 [3.0]                               
      Ulcer                                                         1 [2.0]                   1 [3.0]                               
      Cervix, Hyperplasia, Stromal                     1 [4.0]                                                                      
      Endometrium, Fibrosis                                                                                1 [2.0]                  
      Endometrium, Hyperplasia, Cystic                37 [1.9]     35 [2.2]     34 [2.1]     33 [2.2]     23 [2.1]                  
      Epithelium, Necrosis                             1 [4.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (53)         (53)         (53)         (53)                      
      Hyperplasia                                     36 [3.1]     36 [2.8]     34 [2.7]     41 [3.0]     48 [3.0]                  
   Lymph Node                                         (4)          (1)          (2)          (9)          (11)                      
      Lumbar, Ectasia                                                            1 [2.0]                                            
      Lumbar, Hemorrhage                                                         1 [2.0]                                            
      Lumbar, Hyperplasia, Lymphoid                                              1 [2.0]                   1 [2.0]                  
      Lumbar, Hyperplasia, Plasma Cell                 1 [2.0]                                3 [2.3]                               
      Mediastinal, Ectasia                                          1 [2.0]                   4 [2.0]      2 [2.0]                  
      Mediastinal, Fibrosis                                                                   1 [2.0]                               
      Mediastinal, Hemorrhage                                                                 1 [2.0]      2 [2.0]                  
      Mediastinal, Hyperplasia, Histiocytic                                                   1 [2.0]      1 [2.0]                  
      Mediastinal, Hyperplasia, Lymphoid                                                                   2 [2.5]                  
      Mediastinal, Hyperplasia, Plasma Cell                                                                3 [2.3]                  
      Pancreatic, Ectasia                              1 [3.0]                                                                      
      Pancreatic, Hyperplasia                                                                              1 [4.0]                  
      Pancreatic, Hyperplasia, Histiocytic                                                                 1 [2.0]                  
      Popliteal, Hyperplasia, Plasma Cell                                                     1 [3.0]                               
      Renal, Hyperplasia, Histiocytic                  1 [3.0]                                                                      
   Lymph Node, Mandibular                             (53)         (53)         (53)         (53)         (53)                      
      Ectasia                                                       1 [2.0]      1 [2.0]      2 [3.0]                               
      Hemorrhage                                                                              1 [1.0]                               
      Hyperplasia, Plasma Cell                        31 [2.1]     42 [2.1]     30 [2.1]     22 [2.3]     27 [2.3]                  
      Necrosis, Focal                                                                         1 [3.0]                               
   Lymph Node, Mesenteric                             (52)         (53)         (53)         (53)         (50)                      
      Ectasia                                          1 [2.0]                                                                      
      Hemorrhage                                       1 [3.0]                                             1 [2.0]                  
      Hyperplasia                                                                                          1 [4.0]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/29/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 12:14:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Histiocytic                                                                1 [2.0]      1 [2.0]                  
      Hyperplasia, Lymphoid                                                      1 [4.0]                                            
      Pigmentation                                                                            1 [3.0]                               
   Spleen                                             (52)         (53)         (53)         (53)         (51)                      
      Hematopoietic Cell Proliferation                43 [1.8]     48 [1.5]     42 [1.5]     44 [1.6]     42 [1.6]                  
      Hemorrhage                                                                                           1 [2.0]                  
      Inflammation, Suppurative                                                                            1 [2.0]                  
      Necrosis                                         1 [3.0]                                             1 [3.0]                  
      Pigmentation                                    45 [1.4]     50 [1.3]     52 [1.4]     47 [1.4]     46 [1.1]                  
      Lymphoid Follicle, Atrophy                       1 [2.0]      2 [3.0]      3 [2.0]      2 [2.5]      3 [2.3]                  
      Red Pulp, Atrophy                                             1 [2.0]      3 [2.0]                                            
   Thymus                                             (52)         (48)         (50)         (53)         (50)                      
      Atrophy                                         32 [2.3]     43 [2.9]     45 [3.3]     50 [3.7]     48 [3.9]                  
      Cyst                                             2 [2.5]                                                                      
      Ectopic Thyroid                                                                         1 [4.0]                               
      Hemorrhage                                                                              1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (53)         (53)         (53)         (52)                      
      Cyst                                                          3 [2.7]      1 [2.0]      1 [3.0]                               
      Hyperplasia                                     22 [1.2]      7 [1.6]     14 [1.1]     12 [1.0]      9 [1.0]                  
      Inflammation, Granulomatous                      3 [1.3]      4 [1.8]      1 [3.0]      3 [3.0]      1 [2.0]                  
      Inflammation, Suppurative                                                               1 [2.0]                               
   Skin                                               (53)         (53)         (53)         (53)         (53)                      
      Cyst Epithelial Inclusion                                     2            1            3            3                        
      Hyperkeratosis                                                             1 [2.0]                                            
      Inflammation, Suppurative                                                               1 [2.0]                               
      Ulcer                                                                                   1 [3.0]      1 [2.0]                  
      Hair Follicle, Atrophy                                        1 [4.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (53)         (53)         (53)         (53)         (53)                      
      Mineralization                                                             1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (53)         (53)         (53)         (53)                      
      Edema                                                                                   1 [1.0]      3 [2.0]                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/29/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 12:14:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Gliosis                                          1 [3.0]                                             1 [3.0]                  
      Hemorrhage                                                    1 [2.0]                                                         
      Hydrocephalus                                    1 [1.0]      4 [1.3]      2 [2.0]      2 [2.0]                               
      Inflammation, Granulomatous                                                1 [2.0]                                            
      Mineralization                                   1 [2.0]                   1 [1.0]      1 [1.0]                               
      Necrosis                                                                                             3 [1.7]                  
      Artery, Degeneration                                                                                 1 [3.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (53)         (53)         (53)         (53)                      
      Congestion                                                                 1 [3.0]      1 [3.0]                               
      Cyst                                                                                                 1 [3.0]                  
      Edema                                                                      2 [2.0]      2 [2.5]      1 [2.0]                  
      Hemorrhage                                                                 1 [2.0]                   1 [1.0]                  
      Infiltration Cellular, Histiocyte               43 [1.9]     50 [1.9]     48 [1.6]     48 [1.6]     50 [1.4]                  
      Inflammation                                     4 [1.5]      2 [2.0]      3 [2.0]      1 [3.0]      2 [3.0]                  
      Metaplasia, Squamous                             2 [2.0]                   2 [2.0]      8 [2.0]     11 [1.9]                  
      Mineralization                                                                          1 [1.0]                               
      Alveolar Epithelium, Hyperplasia                21 [1.3]     25 [1.0]     10 [1.3]      2 [1.0]      2 [1.5]                  
      Alveolar Epithelium, Metaplasia, Bronchiolar                 20 [1.8]     33 [1.6]     41 [1.8]     40 [1.9]                  
      Perivascular, Inflammation, Chronic Active                                                           1 [3.0]                  
   Nose                                               (53)         (53)         (53)         (53)         (53)                      
      Inflammation                                     1 [1.0]      2 [1.0]      2 [2.0]      1 [1.0]      1 [2.0]                  
      Goblet Cell, Hyperplasia                                                   2 [2.0]      1 [2.0]                               
      Goblet Cell, Septum, Hyperplasia                                                        1 [2.0]                               
      Nasolacrimal Duct, Inflammation                                                         1 [3.0]                               
      Respiratory Epithelium, Hyperplasia                           1 [1.0]                   4 [1.8]                               
      Turbinate, Cyst                                                                         1 [2.0]                               
      Turbinate, Respiratory Epithelium,                                                                                            
        Hyperplasia                                                                                        1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (53)         (53)         (53)         (53)         (53)                      
      Anterior Chamber, Ciliary Body, Iris,                                                                                         
        Inflammation, Suppurative                                                                          1 [2.0]                  
      Cornea, Inflammation, Suppurative                                                                    1 [3.0]                  
      Lens, Degeneration                                            1 [4.0]                                                         
      Retina, Atrophy                                  1 [3.0]      1 [4.0]      2 [2.0]      1 [2.0]      3 [2.0]                  
   Harderian Gland                                    (53)         (53)         (52)         (53)         (53)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 09/29/03    
Route: GAVAGE                                TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)                 Time: 12:14:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX     TERT.MIX                  
                                                      CONTROL      TEQ=10       TEQ=22       TEQ=46       TEQ=100                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Inflammation                                     8 [1.1]     11 [1.0]      4 [1.3]      5 [1.0]      7 [1.1]                  
      Inflammation, Chronic Active                                                                         1 [4.0]                  
      Necrosis                                                                                             1 [4.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (52)         (53)         (53)         (53)         (51)                      
      Calculus Micro Observation Only                  9 [1.6]      5 [1.8]      8 [1.6]      4 [2.0]      1 [2.0]                  
      Casts Protein                                                              1 [1.0]      1 [1.0]                               
      Cyst                                                          1 [2.0]                   1 [3.0]                               
      Developmental Malformation                                                                           1                        
      Fibrosis                                                                                             1 [2.0]                  
      Inflammation, Chronic                                                                   1 [4.0]                               
      Inflammation, Chronic Active                     1 [2.0]      1 [4.0]      1 [3.0]                                            
      Inflammation, Suppurative                        3 [1.3]      2 [1.0]      3 [1.0]      3 [1.7]      6 [2.8]                  
      Mineralization                                  41 [1.0]     48 [1.0]     47 [1.1]     42 [1.1]     35 [1.2]                  
      Nephropathy                                     26 [1.1]     41 [1.2]     40 [1.3]     47 [1.3]     49 [2.1]                  
      Pelvis, Dilatation                               2 [2.0]                   1 [3.0]      1 [3.0]      1 [2.0]                  
      Pelvis, Inflammation                             2 [2.0]      1 [1.0]      1 [3.0]      2 [2.5]      1 [2.0]                  
      Renal Tubule, Hyperplasia                                                               2 [1.5]                               
      Renal Tubule, Necrosis                           1 [2.0]                   1 [2.0]                                            
      Transitional Epithelium, Hyperplasia             5 [2.0]      5 [1.8]      8 [1.9]     10 [2.0]      8 [2.5]                  
   Ureter                                             (1)                       (1)          (1)          (1)                       
      Cyst                                             1 [3.0]                                                                      
      Inflammation                                                               1 [2.0]                                            
      Metaplasia, Squamous                                                                    1 [2.0]                               
      Transitional Epithelium, Hyperplasia                                       1 [3.0]      1 [3.0]                               
   Urinary Bladder                                    (52)         (52)         (53)         (53)         (50)                      
      Edema                                                                                   1 [2.0]                               
      Hemorrhage                                                                                           1 [2.0]                  
      Inflammation                                    12 [1.0]      3 [1.0]      4 [1.5]      8 [1.4]      5 [2.0]                  
      Metaplasia, Squamous                                                                    1 [3.0]                               
      Transitional Epithelium, Hyperplasia                                       1 [2.0]      3 [2.7]      4 [1.8]                  
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
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