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TDMS Study 96007-05 Pathology Tables

NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03
Route: GAVAGE                                                                                                     Time: 14:49:02

                                                       31 WEEK SSAC RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57117-31-4

       Lock Date:  07/25/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     11/03/99 - 11/04/99

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG/KG                                | 0| 0| 0| 0| 0| 1| 4| 4| 5| 5| 7| 7| 7| 7| 7| 8|                          |      L     |
                                           | 3| 6| 7| 8| 9| 0| 0| 8| 5| 6| 1| 2| 3| 4| 5| 7|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Inflammation                         |    1     1  1  1              1  1  1  1  1                              |      9  1.0|
      Mixed Cell Focus                     |                               X                                          |      1     |
      Mixed Cell Focus, Multiple           |    X        X  X                          X                              |      4     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +              +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +              +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +              +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Hypertrophy                          |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +  +              +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +              +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Hyperplasia                          |                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Follicular Cell, Hypertrophy         |             1  1                                                         |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG/KG                                | 0| 0| 0| 0| 0| 1| 4| 4| 5| 5| 7| 7| 7| 7| 7| 8|                          |      L     |
                                           | 3| 6| 7| 8| 9| 0| 0| 8| 5| 6| 1| 2| 3| 4| 5| 7|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Atrophy                              |    4  4  4  4                          4                                 |      5  4.0|
      Cyst                                 |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Metaplasia, Squamous                 |    2  1  2  1                          2                                 |      5  1.6|
      Endometrium, Hyperplasia, Cystic     |       1  1  1                          2                                 |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |    +  +  +  +  +              +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Pigmentation                         |    2  1  2  2  2              2  2  2  1  2                              |     10  1.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Atrophy                              |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +              +  +  +  +  +                              |  10        |
      Cyst                                 |                                        1                                 |      1  1.0|
      Hyperplasia                          |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +              +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG/KG                                | 0| 0| 0| 0| 0| 1| 4| 4| 5| 5| 7| 7| 7| 7| 7| 8|                          |      L     |
                                           | 3| 6| 7| 8| 9| 0| 0| 8| 5| 6| 1| 2| 3| 4| 5| 7|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |      A     |
    6 NG/KG                                | 1| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 8| 9|                          |      L     |
                                           | 6| 7| 8| 9| 0| 6| 1| 2| 3| 4| 5| 7| 4| 5| 5| 4|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Basophilic Focus                     |    X                          X                                          |      2     |
      Inflammation                         | 1  1  1  1  1     1  1  1  1  1                                          |     10  1.0|
      Mixed Cell Focus                     |    X     X                    X                                          |      3     |
      Mixed Cell Focus, Multiple           |                         X                                                |      1     |
      Pigmentation                         |                            1                                             |      1  1.0|
      Hepatocyte, Hypertrophy              |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Follicular Cell, Hypertrophy         |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Atrophy                              | 4  4  4  4        4  4  4                                                |      7  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Metaplasia, Squamous                 | 2  1  1  2        1     1                                                |      6  1.3|
      Endometrium, Hyperplasia, Cystic     |          2           1                                                   |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     +  +  +  +  +                                          |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |      A     |
    6 NG/KG                                | 1| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 8| 9|                          |      L     |
                                           | 6| 7| 8| 9| 0| 6| 1| 2| 3| 4| 5| 7| 4| 5| 5| 4|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    20 NG/KG                               | 1| 1| 1| 1| 2| 2| 4| 4| 5| 6| 9| 9| 9| 9| 9| 9|                          |      L     |
                                           | 6| 7| 8| 9| 0| 4| 5| 8| 4| 8| 1| 2| 3| 4| 5| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                 +  +  +  +  +                              |  10        |
      Inflammation                         | 1  1  1  1  1                 2  1  2  1  1                              |     10  1.2|
      Mixed Cell Focus                     |                                     X     X                              |      2     |
      Mixed Cell Focus, Multiple           |                               X  X     X                                 |      3     |
      Pigmentation                         |       1                       1  1                                       |      3  1.0|
      Hepatocyte, Hypertrophy              |          1                    1           1                              |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                 +  +  +  +  +                              |  10        |
      Follicular Cell, Hypertrophy         | 1        3                    1  1  1                                    |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                 +  +  +  +  +                              |  10        |
      Atrophy                              | 4  4  4  4                       4     4  4                              |      7  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                 +  +  +  +  +                              |  10        |
      Metaplasia, Squamous                 | 1  2                                      2                              |      3  1.7|
      Endometrium, Hyperplasia, Cystic     | 4  1  1                                   2                              |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                 +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    20 NG/KG                               | 1| 1| 1| 1| 2| 2| 4| 4| 5| 6| 9| 9| 9| 9| 9| 9|                          |      L     |
                                           | 6| 7| 8| 9| 0| 4| 5| 8| 4| 8| 1| 2| 3| 4| 5| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Mammary Gland                           |       +                             +                                    |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 1| 1| 1| 1| 1| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    44 NG/KG                               | 1| 1| 1| 1| 2| 2| 2| 4| 5| 6| 6| 6| 6| 6| 6| 9|                          |      L     |
                                           | 6| 7| 8| 9| 0| 3| 5| 9| 6| 1| 2| 3| 4| 5| 8| 2|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +              +  +  +  +  +                                 |  10        |
      Basophilic Focus                     |       X                                                                  |      1     |
      Inflammation                         | 1  1  1  1  1              1  1  1  1  1                                 |     10  1.0|
      Mixed Cell Focus                     | X                                                                        |      1     |
      Mixed Cell Focus, Multiple           |                            X           X                                 |      2     |
      Pigmentation                         | 1        1  1                          1                                 |      4  1.0|
      Hepatocyte, Hypertrophy              |       1  1                    1  1  1  1                                 |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +              +  +  +  +  +                                 |  10        |
      Follicular Cell, Hypertrophy         | 1        1                       1                                       |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +              +  +  +  +  +                                 |  10        |
      Atrophy                              |    4     4  4              4  4  4                                       |      6  4.0|
      Cyst                                 |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +              +  +  +  +  +                                 |  10        |
      Inflammation, Suppurative            |    2                                                                     |      1  2.0|
      Metaplasia, Squamous                 |          2  2              2  2  2                                       |      5  2.0|
      Endometrium, Hyperplasia, Cystic     | 1  4     1  1              2  2                                          |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +              +  +  +  +  +                                 |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 1| 1| 1| 1| 1| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                          |      A     |
    44 NG/KG                               | 1| 1| 1| 1| 2| 2| 2| 4| 5| 6| 6| 6| 6| 6| 6| 9|                          |      L     |
                                           | 6| 7| 8| 9| 0| 3| 5| 9| 6| 1| 2| 3| 4| 5| 8| 2|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Atrophy                              | 1  1                                                                     |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    92 NG/KG                               | 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 7| 8| 8| 9|                          |      L     |
                                           | 4| 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 0| 3| 0|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +  +  +  +  +  +                                       |  10        |
      Fatty Change, Diffuse                |                            1                                             |      1  1.0|
      Inflammation                         |       1  1  1  1  1  1  1  2  1  1                                       |     10  1.1|
      Mixed Cell Focus                     |                      X           X                                       |      2     |
      Pigmentation                         |          1        1  1  1  1  1  1                                       |      7  1.0|
      Bile Duct, Hyperplasia               |                               1                                          |      1  1.0|
      Hepatocyte, Hypertrophy              |       1  1     1  1  1     1  1  1                                       |      8  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +  +  +  +  +  +                                       |  10        |
      Follicular Cell, Hypertrophy         |          1              1                                                |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +  +  +  +  +  +  +                                       |  10        |
      Atrophy                              |       4  4  4  4  4  4        4  4                                       |      8  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +  +  +  +  +  +                                       |  10        |
      Inflammation, Suppurative            |                      1                                                   |      1  1.0|
      Metaplasia, Squamous                 |       2  2     2     2        1  2                                       |      6  1.8|
      Endometrium, Hyperplasia, Cystic     |       1  2  1  2  3  2           1                                       |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +  +  +  +  +  +  +                                       |  10        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    92 NG/KG                               | 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 7| 8| 8| 9|                          |      L     |
                                           | 4| 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 0| 3| 0|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                +                                                         |   1        |
      Cyst                                 |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    200                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 4| 6| 6| 7| 8| 9|                          |      L     |
    NG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 4| 5| 9| 0| 9| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cholangiofibrosis                    |                1                                                         |      1  1.0|
      Eosinophilic Focus                   |                         X                                                |      1     |
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Mixed Cell Focus                     |                         X                                                |      1     |
      Mixed Cell Focus, Multiple           |          X  X  X           X                                             |      4     |
      Pigmentation                         | 1     1  1  1  1  1     1  1                                             |      8  1.0|
      Bile Duct, Fibrosis                  |                1                                                         |      1  1.0|
      Hepatocyte, Hypertrophy              | 1  1     1  1  1  1     1  2                                             |      8  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          |                3        1                                                |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicular Cell, Hypertrophy         |          2        1     1                                                |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    200                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 4| 6| 6| 7| 8| 9|                          |      L     |
    NG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 4| 5| 9| 0| 9| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 4  4  4     4  4  4  4  4  4                                             |      9  4.0|
      Cyst                                 |    2  1                                                                  |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Suppurative            |                            1                                             |      1  1.0|
      Metaplasia, Squamous                 | 1           1           2                                                |      3  1.3|
      Endometrium, Hyperplasia, Cystic     | 2  2     4  4  4  2     1  4                                             |      8  2.9|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pigmentation                         | 2  1  2  2  2  2  1  1  2  2                                             |     10  1.7|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 2     2     2     3  3                                                   |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:49:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    200                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 4| 6| 6| 7| 8| 9|                          |      L     |
    NG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 4| 5| 9| 0| 9| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
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