Share This:
https://ntp.niehs.nih.gov/go/6160

TDMS Study 96007-05 Pathology Tables

NTP Experiment-Test: 96007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03
Route: GAVAGE                                                                                                     Time: 14:54:42

                                                       53 WEEK SSAC RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57117-31-4

       Lock Date:  07/25/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     04/06/00 - 04/07/00

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:54:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      6 NG/KG      20 NG/KG     44 NG/KG     92 NG/KG     200             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98           98           98           98           98           
                                                                                                                                    
  Scheduled Sacrifice                                 13           13           13           13           13           13           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8            8            8            8            8            8           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (8)          (8)          (8)          (8)          (8)          
      Angiectasis                                      1 (13%)                                                                      
      Basophilic Focus                                 1 (13%)      1 (13%)                   3 (38%)                   1 (13%)     
      Clear Cell Focus, Multiple                                                                                        1 (13%)     
      Eosinophilic Focus                                                                                                1 (13%)     
      Fatty Change, Diffuse                                                                                             3 (38%)     
      Hepatodiaphragmatic Nodule                                    1 (13%)                                                         
      Inflammation                                     8 (100%)     8 (100%)     8 (100%)     7 (88%)      8 (100%)     8 (100%)    
      Mixed Cell Focus                                 2 (25%)      1 (13%)      3 (38%)      1 (13%)      3 (38%)                  
      Mixed Cell Focus, Multiple                       5 (63%)      5 (63%)      3 (38%)      7 (88%)      3 (38%)      6 (75%)     
      Necrosis                                         1 (13%)      1 (13%)      2 (25%)                                            
      Pigmentation                                                  1 (13%)      1 (13%)      6 (75%)      7 (88%)      8 (100%)    
      Toxic Hepatopathy                                                                                                 1 (13%)     
      Bile Duct, Cyst                                                                                                   2 (25%)     
      Bile Duct, Fibrosis                              1 (13%)                   1 (13%)      1 (13%)                               
      Bile Duct, Hyperplasia                                                                               1 (13%)      1 (13%)     
      Hepatocyte, Hypertrophy                          1 (13%)      3 (38%)      3 (38%)      3 (38%)      5 (63%)      7 (88%)     
      Hepatocyte, Multinucleated                                                                           1 (13%)      2 (25%)     
   Pancreas                                           (8)                                                              (8)          
      Hyperplasia                                      1 (13%)                                                                      
      Inflammation, Chronic Active                     1 (13%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (8)                                                              (8)          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:54:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      6 NG/KG      20 NG/KG     44 NG/KG     92 NG/KG     200             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Degeneration, Cystic                                                                                              1 (13%)     
      Hyperplasia                                      1 (13%)                                                          2 (25%)     
      Hypertrophy                                      4 (50%)                                                          6 (75%)     
      Vacuolization Cytoplasmic                                                                                         2 (25%)     
   Pituitary Gland                                    (8)                                                              (8)          
      Hyperplasia                                                                                                       2 (25%)     
      Pars Distalis, Hyperplasia                       1 (13%)                                                                      
   Thyroid Gland                                      (8)          (8)          (7)          (8)          (8)          (8)          
      C-Cell, Hyperplasia                                                                                               2 (25%)     
      Follicular Cell, Hypertrophy                     2 (25%)      3 (38%)      1 (14%)      3 (38%)      4 (50%)      5 (63%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)          (1)          (2)          (1)                       (8)          
      Atrophy                                          8 (100%)                                                         7 (88%)     
      Cyst                                             1 (13%)                   2 (100%)                                           
   Oviduct                                                         (1)                                                              
      Cyst                                                          1 (100%)                                                        
   Uterus                                             (8)          (1)          (2)          (1)          (1)          (8)          
      Inflammation, Chronic Active                                               2 (100%)                  1 (100%)                 
      Inflammation, Suppurative                        2 (25%)                                                          1 (13%)     
      Metaplasia, Squamous                             8 (100%)     1 (100%)     1 (50%)                                7 (88%)     
      Endometrium, Hyperplasia, Cystic                 6 (75%)                                1 (100%)     1 (100%)     8 (100%)    
      Epithelium, Hyperplasia                                                    2 (100%)                                           
   Vagina                                             (8)                                                              (8)          
      Vacuolization Cytoplasmic                                                                                         1 (13%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (8)                                                              (8)          
      Pigmentation                                     8 (100%)                                                         8 (100%)    
   Thymus                                             (8)          (8)          (8)          (8)          (8)          (8)          
      Atrophy                                          5 (63%)      4 (50%)      6 (75%)      6 (75%)      5 (63%)      7 (88%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:54:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      6 NG/KG      20 NG/KG     44 NG/KG     92 NG/KG     200             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (8)          (1)          (1)                       (2)          (8)          
      Cyst                                                                       1 (100%)                  1 (50%)      1 (13%)     
      Hyperplasia                                                                                                       3 (38%)     
      Inflammation, Chronic                                                      1 (100%)                  1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (1)                                                 (8)          
      Infiltration Cellular, Histiocyte                4 (50%)      1 (100%)                                            2 (25%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (1)                                                                           
      Inflammation, Chronic                            1 (100%)                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:54:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                200 NG/                                                                          
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50                                                                            
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                                                                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 07/14/03    
Route: GAVAGE                                                                                                     Time: 14:54:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                200 NG/                                                                          
                                                   KG STOP                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------