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TDMS Study 96007-05 Pathology Tables

NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03
Route: GAVAGE                                                                                                     Time: 11:22:54

                                                         FINAL #3/RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57117-31-4

       Lock Date:  07/25/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 5| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 0| 2| 0| 7| 3| 2| 5| 2| 2| 2| 2| 2| 5| 2| 7| 5| 1| 9| 2| 7| 2| 2| 2|             
                                           | 0| 7| 0| 8| 0| 5| 6| 9| 4| 8| 9| 8| 8| 8| 1| 8| 8| 2| 5| 9| 9| 8| 9| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 5| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +  +  +     +  +        +  +  +  +        +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 5| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 0| 2| 0| 7| 3| 2| 5| 2| 2| 2| 2| 2| 5| 2| 7| 5| 1| 9| 2| 7| 2| 2| 2|             
                                           | 0| 7| 0| 8| 0| 5| 6| 9| 4| 8| 9| 8| 8| 8| 1| 8| 8| 2| 5| 9| 9| 8| 9| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 5| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                                   |             
      Carcinoma                            |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |          X                    X     X           X        X           X   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |          X  X                       X  X  X           X     X     X      |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Luteoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 5| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 0| 2| 0| 7| 3| 2| 5| 2| 2| 2| 2| 2| 5| 2| 7| 5| 1| 9| 2| 7| 2| 2| 2|             
                                           | 0| 7| 0| 8| 0| 5| 6| 9| 4| 8| 9| 8| 8| 8| 1| 8| 8| 2| 5| 9| 9| 8| 9| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 5| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Oviduct                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                       X         |             
      Carcinoma                            |                                                                          |             
      Fibroma                              |                                                                          |             
      Polyp Stromal                        |          X                                      X     X        X         |             
      Polyp Stromal, Multiple              |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |          +                                                               |             
      Squamous Cell Papilloma              |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                            +                    +                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
      Carcinoma                            |                                     X              X                 X   |             
      Fibroadenoma                         |       X           X     X  X  X     X     X                    X  X     X|             
      Fibroadenoma, Multiple               |             X  X                                X                    X   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 5| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 0| 2| 0| 7| 3| 2| 5| 2| 2| 2| 2| 2| 5| 2| 7| 5| 1| 9| 2| 7| 2| 2| 2|             
                                           | 0| 7| 0| 8| 0| 5| 6| 9| 4| 8| 9| 8| 8| 8| 1| 8| 8| 2| 5| 9| 9| 8| 9| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 5| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lipoma                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 7| 7| 7| 6| 3| 6| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 2| 2| 2| 7| 2| 5| 3| 1| 7| 2| 8| 1| 2| 2| 2| 5| 2| 0| 3| 3| 1| 2|             
                                           | 9| 5| 9| 9| 9| 9| 8| 1| 1| 0| 3| 8| 0| 8| 9| 9| 8| 9| 9| 8| 3| 0| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 4| 6| 7| 9| 0| 2| 3| 4| 7| 9| 0| 1| 2| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                   X                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +           +        +  +  +     +     +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 7| 7| 7| 6| 3| 6| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 2| 2| 2| 7| 2| 5| 3| 1| 7| 2| 8| 1| 2| 2| 2| 5| 2| 0| 3| 3| 1| 2|             
                                           | 9| 5| 9| 9| 9| 9| 8| 1| 1| 0| 3| 8| 0| 8| 9| 9| 8| 9| 9| 8| 3| 0| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 4| 6| 7| 9| 0| 2| 3| 4| 7| 9| 0| 1| 2| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Schwannoma Malignant                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Complex             |                                                    X                     |             
      Pheochromocytoma Benign              |                                                       X  X     X         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                X  X     X        X  X        X           X  X  X         |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |    X                          X                                   X     X|             
      C-Cell, Carcinoma                    |                X                                         X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Luteoma                              |    X                                                                     |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 7| 7| 7| 6| 3| 6| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 2| 2| 2| 7| 2| 5| 3| 1| 7| 2| 8| 1| 2| 2| 2| 5| 2| 0| 3| 3| 1| 2|             
                                           | 9| 5| 9| 9| 9| 9| 8| 1| 1| 0| 3| 8| 0| 8| 9| 9| 8| 9| 9| 8| 3| 0| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 4| 6| 7| 9| 0| 2| 3| 4| 7| 9| 0| 1| 2| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Oviduct                                 |                         +                                                |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                   X                                                      |             
      Fibroma                              |                   X                                                      |             
      Polyp Stromal                        |                            X              X  X                           |             
      Polyp Stromal, Multiple              |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                    +                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                           X              X               |             
      Fibroadenoma                         | X           X     X  X     X  X     X  X           X        X           X|             
      Fibroadenoma, Multiple               |    X                    X        X                             X  X  X   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 7| 7| 7| 6| 3| 6| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 2| 2| 2| 7| 2| 5| 3| 1| 7| 2| 8| 1| 2| 2| 2| 5| 2| 0| 3| 3| 1| 2|             
                                           | 9| 5| 9| 9| 9| 9| 8| 1| 1| 0| 3| 8| 0| 8| 9| 9| 8| 9| 9| 8| 3| 0| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 4| 6| 7| 9| 0| 2| 3| 4| 7| 9| 0| 1| 2| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |                                           X                              |             
      Carcinoma, Metastatic, Thyroid Gland |                                                          X               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lipoma                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  52        |
      Gingival, Squamous Cell Carcinoma    |    X                                                                     |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +                                                                     |  33        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          4 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Pars Distalis, Adenoma               |                                                                          |         15 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Adenoma                      | X                                                                        |         13 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
   Clitoral Gland                          | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Luteoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          1 |
      Fibroma                              |                                                                          |          1 |
      Polyp Stromal                        |       X                                                                  |          8 |
      Polyp Stromal, Multiple              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   5        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          5 |
      Fibroadenoma                         | X  X  X                                                                  |         24 |
      Fibroadenoma, Multiple               |                                                                          |         10 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 0| 0| 0|                                                                 |     A      |
    0 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Lipoma                               | X                                                                        |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Squamous Cell Carcinoma    |                   X  X                                                   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +     +     +  +  +     +        +  +        +     +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Schwannoma Malignant                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Pars Distalis, Adenoma               | X  X     X  X  X                    X                       X  X  X  X  X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |          X                             X  X              X               |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Granulosa Cell Tumor Malignant       |                                                                          |             
      Granulosa Cell Tumor Benign          |                                           X                              |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                   X                                                      |             
      Polyp Stromal                        |                                                                          |             
      Cervix, Sarcoma Stromal              |                                                                          |             
      Cervix, Schwannoma Malignant         |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
      Sarcoma Stromal                      |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                              +        +                  |             
      Mediastinal, Leukemia Mononuclear    |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
      Carcinoma                            |                X              X     X                                    |             
      Carcinoma, Multiple                  |    X                                                                     |             
      Fibroadenoma                         |          X  X     X     X  X     X        X  X  X           X        X  X|             
      Fibroadenoma, Multiple               |    X           X                                               X  X      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Neurofibroma                         |                                                                         X|             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Oral Mucosa   |                   X                                                      |             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +        +  +           +     +  +     +     +  +           +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Schwannoma Malignant                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              | X                                            X        X        X         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |          X                                                               |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                      X   |             
      Pars Distalis, Adenoma               | X              X              X     X     X  X        X           X      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                      X                    X  X        X        X         |             
      C-Cell, Carcinoma                    | X                                                  X                     |             
      Follicular Cell, Adenoma             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Carcinoma, Metastatic, Mammary Gland |                                                                         X|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Granulosa Cell Tumor Malignant       | X                                                                        |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Polyp Stromal                        |                                           X           X                  |             
      Cervix, Sarcoma Stromal              |          X                                                               |             
      Cervix, Schwannoma Malignant         |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                 +        +               |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                            X                       X  X                 X|             
      Carcinoma, Multiple                  |                X                                                     X   |             
      Fibroadenoma                         | X     X     X     X     X  X     X  X              X        X        X   |             
      Fibroadenoma, Multiple               |                X     X                    X           X        X  X     X|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                         X                                                |             
      Neurofibroma                         |                                                                          |             
      Schwannoma Malignant                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                      X   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Oral Mucosa   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    6 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   2        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Squamous Cell Carcinoma    |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    6 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
   Tooth                                   |                                                                          |  25        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Pheochromocytoma Benign              |                                                                          |          5 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  51        |
      Adenoma                              |    X                                                                     |          2 |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Carcinoma                            |                                                                          |          1 |
      Pars Distalis, Adenoma               |    X  X                                                                  |         21 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      Bilateral, C-Cell, Adenoma           | X                                                                        |          1 |
      C-Cell, Adenoma                      |                                                                          |          9 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    6 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  51        |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Cystadenoma                          | X                                                                        |          1 |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Carcinoma                            |                                                                          |          1 |
      Polyp Stromal                        | X                                                                        |          3 |
      Cervix, Sarcoma Stromal              |                                                                          |          1 |
      Cervix, Schwannoma Malignant         |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Sarcoma Stromal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    6 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            | X     X                                                                  |          9 |
      Carcinoma, Multiple                  |                                                                          |          3 |
      Fibroadenoma                         |                                                                          |         23 |
      Fibroadenoma, Multiple               |    X                                                                     |         12 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Fibroma                              |                                                                          |          1 |
      Neurofibroma                         |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Osteosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    6 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Oral Mucosa   |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________      T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    6 NG/KG                                | 9| 9| 9|                                                                 |     L      |
                                           | 5| 6| 7|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 2| 2| 7| 5| 7| 7| 7| 6| 7| 4| 4| 7| 6| 7| 7| 5| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 8| 3| 1| 4| 3| 6| 2| 2| 2| 0| 3| 9| 2| 2| 7| 2| 2| 8| 9| 3| 2| 1| 8|             
                                           | 9| 8| 4| 0| 9| 6| 0| 1| 8| 8| 8| 5| 0| 7| 0| 9| 5| 8| 9| 6| 3| 0| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +  +              +  +  +  +  +  +     +  +  +  +  +              +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 2| 2| 7| 5| 7| 7| 7| 6| 7| 4| 4| 7| 6| 7| 7| 5| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 8| 3| 1| 4| 3| 6| 2| 2| 2| 0| 3| 9| 2| 2| 7| 2| 2| 8| 9| 3| 2| 1| 8|             
                                           | 9| 8| 4| 0| 9| 6| 0| 1| 8| 8| 8| 5| 0| 7| 0| 9| 5| 8| 9| 6| 3| 0| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X     X              X  X  X  X  X     X        X  X  X           X  X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |          X              X                             X           X      |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 2| 2| 7| 5| 7| 7| 7| 6| 7| 4| 4| 7| 6| 7| 7| 5| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 8| 3| 1| 4| 3| 6| 2| 2| 2| 0| 3| 9| 2| 2| 7| 2| 2| 8| 9| 3| 2| 1| 8|             
                                           | 9| 8| 4| 0| 9| 6| 0| 1| 8| 8| 8| 5| 0| 7| 0| 9| 5| 8| 9| 6| 3| 0| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Polyp Stromal                        |                         X                             X                  |             
      Cervix, Polyp Stromal                |                                                                   X      |             
      Cervix, Squamous Cell Carcinoma      |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Polyp                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                      +                                                   |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Thyroid Gland                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
      Carcinoma                            |             X  X  X     X  X                                   X         |             
      Carcinoma, Multiple                  |                                                                         X|             
      Fibroadenoma                         | X     X           X  X     X  X              X  X  X        X        X  X|             
      Fibroadenoma, Multiple               |    X     X                                                     X  X      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                   X      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 2| 2| 7| 5| 7| 7| 7| 6| 7| 4| 4| 7| 6| 7| 7| 5| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 8| 3| 1| 4| 3| 6| 2| 2| 2| 0| 3| 9| 2| 2| 7| 2| 2| 8| 9| 3| 2| 1| 8|             
                                           | 9| 8| 4| 0| 9| 6| 0| 1| 8| 8| 8| 5| 0| 7| 0| 9| 5| 8| 9| 6| 3| 0| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                          X               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephroblastoma                       |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 3| 6| 3| 7| 4| 1| 5| 6| 2| 1| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 2| 0| 1| 3| 3| 3| 2| 3| 7| 0| 7| 0| 2| 5| 1| 8| 3| 9| 9| 2| 6| 3| 8|             
                                           | 8| 0| 9| 1| 7| 0| 0| 0| 8| 6| 5| 1| 7| 0| 8| 1| 6| 7| 8| 7| 6| 9| 8| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 0| 1| 2| 3| 4| 6| 7| 2| 5| 6| 7| 8| 9| 0| 6| 7| 9| 1| 3| 5| 7| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Squamous Cell Carcinoma    |             X                                                            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                            +           +           +                 +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 3| 6| 3| 7| 4| 1| 5| 6| 2| 1| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 2| 0| 1| 3| 3| 3| 2| 3| 7| 0| 7| 0| 2| 5| 1| 8| 3| 9| 9| 2| 6| 3| 8|             
                                           | 8| 0| 9| 1| 7| 0| 0| 0| 8| 6| 5| 1| 7| 0| 8| 1| 6| 7| 8| 7| 6| 9| 8| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 0| 1| 2| 3| 4| 6| 7| 2| 5| 6| 7| 8| 9| 0| 6| 7| 9| 1| 3| 5| 7| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Heart                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                      X                                                   |             
      Pheochromocytoma Benign              |          X                                X                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  M  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X        X  X     X  X  X     X                          X  X      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           | X                                                                        |             
      C-Cell, Adenoma                      |                            X                                      X  X   |             
      C-Cell, Carcinoma                    |                X           X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                                               |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          | X                                                                        |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 3| 6| 3| 7| 4| 1| 5| 6| 2| 1| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 2| 0| 1| 3| 3| 3| 2| 3| 7| 0| 7| 0| 2| 5| 1| 8| 3| 9| 9| 2| 6| 3| 8|             
                                           | 8| 0| 9| 1| 7| 0| 0| 0| 8| 6| 5| 1| 7| 0| 8| 1| 6| 7| 8| 7| 6| 9| 8| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 0| 1| 2| 3| 4| 6| 7| 2| 5| 6| 7| 8| 9| 0| 6| 7| 9| 1| 3| 5| 7| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Polyp Stromal                        |                               X                                      X   |             
      Cervix, Polyp Stromal                |                                                                          |             
      Cervix, Squamous Cell Carcinoma      |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |       +                                                                  |             
      Polyp                                |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                            +                          +     +            |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                            X                                             |             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Thyroid Gland                   |                            X                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
      Carcinoma                            |                      X                                   X        X      |             
      Carcinoma, Multiple                  |    X                                                                     |             
      Fibroadenoma                         | X           X     X     X  X  X                    X           X  X     X|             
      Fibroadenoma, Multiple               |          X                                   X        X                  |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 3| 6| 3| 7| 4| 1| 5| 6| 2| 1| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 2| 0| 1| 3| 3| 3| 2| 3| 7| 0| 7| 0| 2| 5| 1| 8| 3| 9| 9| 2| 6| 3| 8|             
                                           | 8| 0| 9| 1| 7| 0| 0| 0| 8| 6| 5| 1| 7| 0| 8| 1| 6| 7| 8| 7| 6| 9| 8| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 0| 1| 2| 3| 4| 6| 7| 2| 5| 6| 7| 8| 9| 0| 6| 7| 9| 1| 3| 5| 7| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosarcoma                         |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                            X                                             |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephroblastoma                       |                                                             X            |             
      Renal Tubule, Adenoma                |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    20 NG/KG                               | 9| 9| 9|                                                                 |     L      |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Hepatocellular Adenoma               |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  52        |
      Gingival, Squamous Cell Carcinoma    |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +  +                                                                  |  22        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    20 NG/KG                               | 9| 9| 9|                                                                 |     L      |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |       X                                                                  |          1 |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  44        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Pars Distalis, Adenoma               |       X                                                                  |         23 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |    X                                                                     |          8 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    20 NG/KG                               | 9| 9| 9|                                                                 |     L      |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Polyp Stromal                        | X                                                                        |          5 |
      Cervix, Polyp Stromal                |                                                                          |          1 |
      Cervix, Squamous Cell Carcinoma      |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Polyp                                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
           Thyroid Gland                   |                                                                          |          1 |
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |            |
           Thyroid Gland                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +                                                                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    20 NG/KG                               | 9| 9| 9|                                                                 |     L      |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |    X  X                                                                  |         11 |
      Carcinoma, Multiple                  |                                                                          |          2 |
      Fibroadenoma                         |       X                                                                  |         23 |
      Fibroadenoma, Multiple               |                                                                          |          7 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Fibroma                              |                                                                          |          1 |
      Fibrosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Astrocytoma Malignant                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Sarcoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    20 NG/KG                               | 9| 9| 9|                                                                 |     L      |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Nephroblastoma                       |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                                          |             
      Lymphoma Malignant                   |                                                             X            |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                             X            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +        +        +     +  +  +  +  +  +  +     +           +     +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                             X            |             
      Schwannoma Malignant                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                             X            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                      X                                         X        X|             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X        X  X  X              X           X           X        X        X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                           X                              |             
      C-Cell, Adenoma                      |    X     X                                                               |             
      C-Cell, Carcinoma                    |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Sertoli Cell Tumor Malignant         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leiomyoma                            |                                        X                                 |             
      Polyp Stromal                        |                                        X                                 |             
      Schwannoma Malignant                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                             +            |             
      Mediastinal, Lymphoma Malignant      |                                                             X            |             
      Pancreatic, Lymphoma Malignant       |                                                             X            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                             X            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                             X            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                X         |             
      Fibroadenoma                         | X  X           X  X        X                 X     X              X     X|             
      Fibroadenoma, Multiple               |                                                             X            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Hemangioma      |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |          +              +                                                |             
      Rhabdomyosarcoma                     |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granular Cell Tumor Malignant        |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                             +            |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                             X            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                             X            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                          X               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                  X                                       |             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                         +                                +               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +        +        +  +  +  +  +     +           +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Schwannoma Malignant                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                           X                 X            |             
      Bilateral, Pheochromocytoma Benign   |                                                          X               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X              X           X  X  X  X  X  X     X        X        X  X   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                X  X              X  X     X                 X            |             
      C-Cell, Carcinoma                    | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Sertoli Cell Tumor Malignant         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                          X               |             
      Leiomyoma                            |                                                                          |             
      Polyp Stromal                        |                   X                 X                             X     X|             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                       +              +                           |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                           X                              |             
      Fibroadenoma                         |             X        X  X  X        X           X     X     X     X     X|             
      Fibroadenoma, Multiple               |    X           X              X  X     X     X                           |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                             X            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Rhabdomyosarcoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granular Cell Tumor Malignant        |             X                                                            |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    44 NG/KG                               | 8| 9| 9|                                                                 |     L      |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  52        |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   3        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    44 NG/KG                               | 8| 9| 9|                                                                 |     L      |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
   Tooth                                   |    +                                                                     |  30        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  52        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Pheochromocytoma Benign              |                                                                          |          5 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Pars Distalis, Adenoma               | X  X                                                                     |         23 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          8 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    44 NG/KG                               | 8| 9| 9|                                                                 |     L      |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
      Sertoli Cell Tumor Malignant         | X                                                                        |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Carcinoma                            |                                                                          |          1 |
      Leiomyoma                            |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          5 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
      Mediastinal, Lymphoma Malignant      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  52        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    44 NG/KG                               | 8| 9| 9|                                                                 |     L      |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Carcinoma                            |                                                                          |          2 |
      Fibroadenoma                         |    X  X                                                                  |         21 |
      Fibroadenoma, Multiple               | X                                                                        |          8 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Fibroma                              |                                                                          |          1 |
      Subcutaneous Tissue, Hemangioma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Rhabdomyosarcoma                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Granular Cell Tumor Malignant        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    44 NG/KG                               | 8| 9| 9|                                                                 |     L      |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  52        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
      Cholangiocarcinoma                   |             X                                                            |             
      Hepatocellular Adenoma               |          X                                                               |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
      Acinus, Adenoma                      |                                                    X                     |             
      Acinus, Carcinoma                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +        +  +  +     +  +  +           +        +           +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                             X      |             
      Carcinoma                            |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                         X|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X           X        X  X           X     X     X  X     X           X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      C-Cell, Adenoma                      |             X                 X                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                         X     X                                         X|             
      Polyp Stromal                        |                X                                                     X  X|             
      Polyp Stromal, Multiple              |                                                                          |             
      Squamous Cell Carcinoma              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                    X                     |             
      Carcinoma                            |          X  X                 X                                          |             
      Fibroadenoma                         | X  X  X     X  X     X           X     X     X  X        X        X      |             
      Fibroadenoma, Multiple               |          X        X     X  X                                         X   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Cranial Nerve, Squamous Cell         |                                                                          |             
          Carcinoma, Metastatic, Oral      |                                                                          |             
          Mucosa                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephroblastoma                       |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                     X                                    |             
      Cholangiocarcinoma                   |                                                                          |             
      Hepatocellular Adenoma               |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Squamous Cell Carcinoma    |                               X                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                     X                                    |             
      Acinus, Adenoma                      |                                                                          |             
      Acinus, Carcinoma                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +  +  +        +  +  +     +     +  +        +        +        +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |             X           X        X  X     X              X  X           X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                         X  X                                            X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Oviduct                                 |       +                                                                  |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                            X        X                                    |             
      Polyp Stromal                        |                               X     X                                    |             
      Polyp Stromal, Multiple              |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                             +                    +               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                   X                       X                              |             
      Fibroadenoma                         | X     X        X     X     X           X        X        X  X     X      |             
      Fibroadenoma, Multiple               |             X                    X                 X                    X|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                             X            |             
      Cranial Nerve, Squamous Cell         |                                                                          |             
          Carcinoma, Metastatic, Oral      |                                                                          |             
          Mucosa                           |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Mammary Gland |                   X                                                      |             
      Carcinoma, Metastatic, Uterus        |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
      Adenoma                              |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephroblastoma                       |                                                                X         |             
      Renal Tubule, Adenoma                |                                                          X               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                     X                                    |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    92 NG/KG                               | 9| 9| 9|                                                                 |     L      |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Squamous Cell Carcinoma    |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
      Acinus, Adenoma                      |                                                                          |          1 |
      Acinus, Carcinoma                    | X                                                                        |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    92 NG/KG                               | 9| 9| 9|                                                                 |     L      |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |  29        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +                                                                  |  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Pars Distalis, Adenoma               | X     X                                                                  |         21 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      C-Cell, Adenoma                      |                                                                          |          6 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    92 NG/KG                               | 9| 9| 9|                                                                 |     L      |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Carcinoma                            |                                                                          |          5 |
      Polyp Stromal                        |       X                                                                  |          6 |
      Polyp Stromal, Multiple              | X                                                                        |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    92 NG/KG                               | 9| 9| 9|                                                                 |     L      |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroadenoma                         |                                                                          |         22 |
      Fibroadenoma, Multiple               | X  X  X                                                                  |         12 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Cranial Nerve, Squamous Cell         |                                                                          |            |
          Carcinoma, Metastatic, Oral      |                                                                          |            |
          Mucosa                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    92 NG/KG                               | 9| 9| 9|                                                                 |     L      |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Harderian Gland                         | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Nephroblastoma                       |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  51        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                          X               |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
      Cholangiocarcinoma                   |                                                 X                        |             
      Cholangiocarcinoma, Multiple         |                                              X                           |             
      Hepatocellular Adenoma               |          X        X                                      X               |             
      Leukemia Mononuclear                 |                                              X                           |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                                +              +                    +   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Squamous Cell Carcinoma    |                                                    X                 X   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +        +        +  +     +     +     +  +  +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Pars Distalis, Adenoma               | X     X  X                                   X  X           X        X   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                            X                 X  X     X                  |             
      C-Cell, Carcinoma                    |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                   X                                                      |             
      Polyp Stromal                        |                                  X                 X                     |             
      Polyp Stromal, Multiple              |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                                                                    +  +|             
      Inguinal, Carcinoma, Metastatic,     |                                                                          |             
           Mammary Gland                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
      Leukemia Mononuclear                 |                                              X                           |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma, Metastatic, Skin       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                   X                                                      |             
      Fibroadenoma                         |    X        X        X  X                    X     X        X            |             
      Fibroadenoma, Multiple               |          X        X                 X           X     X  X               |             
      Osteosarcoma, Metastatic, Skin       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Fibrous Histiocytoma                 |                                                                          |             
      Keratoacanthoma                      |                                                    X                     |             
      Neural Crest Tumor                   |                                           X                              |             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                   X      |             
      Leukemia Mononuclear                 |                                              X                           |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                         X|             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
      Carcinoma, Metastatic, Uterus        |                                                                          |             
      Cystic Keratinizing Epithelioma,     |                                                                          |             
           Multiple                        |                                                    X                     |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |                                              X                           |             
      Osteosarcoma, Metastatic, Skin       |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Leukemia Mononuclear                 |                                              X                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                           X                              |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                           X                              |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                           X                              |             
      Cholangiocarcinoma                   |                                                                          |             
      Cholangiocarcinoma, Multiple         |                                                                          |             
      Hepatocellular Adenoma               |                                                 X                        |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Squamous Cell Carcinoma    |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                           X                              |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                      X   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                           X                              |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +     +     +     +  +     +  +  +  +  +  +     +     +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                           X                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X     X  X                    X     X           X           X         |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                      X                       X                           |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                           X                              |             
      Polyp Stromal                        |                                                             X            |             
      Polyp Stromal, Multiple              |                X                                                         |             
      Schwannoma Malignant                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +                             +                       +           +   |             
      Inguinal, Carcinoma, Metastatic,     |                                                                          |             
           Mammary Gland                   |                                                          X               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uterus        |                                           X                              |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma, Metastatic, Skin       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                X                                         X               |             
      Fibroadenoma                         | X        X     X                       X        X     X        X  X  X  X|             
      Fibroadenoma, Multiple               |    X                                X     X  X                           |             
      Osteosarcoma, Metastatic, Skin       |                                     X                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              | X                                                                        |             
      Fibrous Histiocytoma                 |                   X                                                      |             
      Keratoacanthoma                      |                                                                          |             
      Neural Crest Tumor                   |                                                                          |             
      Osteosarcoma                         |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                               +                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Mammary Gland |                X                                         X               |             
      Carcinoma, Metastatic, Uterus        |                                           X                              |             
      Cystic Keratinizing Epithelioma,     |                                                                          |             
           Multiple                        |                                                                          |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                   X                                                      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic, Skin       |                                     X                                    |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 5| 5| 5|                                                                 |     A      |
    200                                    | 9| 9| 9|                                                                 |     L      |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
      Leiomyoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Cholangiocarcinoma, Multiple         |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          4 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Squamous Cell Carcinoma    |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 5| 5| 5|                                                                 |     A      |
    200                                    | 9| 9| 9|                                                                 |     L      |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Fibrosarcoma                         |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |  29        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Pheochromocytoma Benign              |    X                                                                     |          2 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
      Adenoma                              |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 5| 5| 5|                                                                 |     A      |
    200                                    | 9| 9| 9|                                                                 |     L      |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               | X     X                                                                  |         16 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      C-Cell, Adenoma                      |    X                                                                     |          7 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Carcinoma                            |                                                                          |          2 |
      Polyp Stromal                        |                                                                          |          3 |
      Polyp Stromal, Multiple              |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   7        |
      Inguinal, Carcinoma, Metastatic,     |                                                                          |            |
           Mammary Gland                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 5| 5| 5|                                                                 |     A      |
    200                                    | 9| 9| 9|                                                                 |     L      |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  51        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  51        |
      Osteosarcoma, Metastatic, Skin       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Carcinoma                            |                                                                          |          3 |
      Fibroadenoma                         |                                                                          |         17 |
      Fibroadenoma, Multiple               | X  X  X                                                                  |         13 |
      Osteosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Fibroma                              |                                                                          |          1 |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Neural Crest Tumor                   |                                                                          |          1 |
      Osteosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 5| 5| 5|                                                                 |     A      |
    200                                    | 9| 9| 9|                                                                 |     L      |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  52        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          2 |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
      Cystic Keratinizing Epithelioma,     |                                                                          |            |
           Multiple                        |                                                                          |          1 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Osteosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
      Sarcoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 5| 5| 5|                                                                 |     A      |
    200                                    | 9| 9| 9|                                                                 |     L      |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 5| 7| 7| 2| 7| 6| 7| 7| 6| 6| 6| 7| 6| 7| 5| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 1| 0| 2| 2| 7| 3| 0| 2| 1| 1| 9| 1| 2| 3| 2| 0| 2| 2| 1| 0| 2| 1| 0|             
                                           | 0| 4| 6| 3| 8| 8| 6| 0| 5| 8| 6| 0| 9| 0| 8| 8| 8| 0| 8| 8| 5| 0| 5| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    200 NG/                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Uterus                          |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Squamous Cell Carcinoma    |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                          X               |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +     +     +              +     +     +  +     +  +     +  +     +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 5| 7| 7| 2| 7| 6| 7| 7| 6| 6| 6| 7| 6| 7| 5| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 1| 0| 2| 2| 7| 3| 0| 2| 1| 1| 9| 1| 2| 3| 2| 0| 2| 2| 1| 0| 2| 1| 0|             
                                           | 0| 4| 6| 3| 8| 8| 6| 0| 5| 8| 6| 0| 9| 0| 8| 8| 8| 0| 8| 8| 5| 0| 5| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    200 NG/                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X                    X        X  X                 X        X     X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      C-Cell, Adenoma                      |                                                 X                       X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Luteoma                              |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Carcinoma                            |                                                          X               |             
      Hemangioma                           |                               X                                          |             
      Polyp Stromal                        |                      X                                         X         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 5| 7| 7| 2| 7| 6| 7| 7| 6| 6| 6| 7| 6| 7| 5| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 1| 0| 2| 2| 7| 3| 0| 2| 1| 1| 9| 1| 2| 3| 2| 0| 2| 2| 1| 0| 2| 1| 0|             
                                           | 0| 4| 6| 3| 8| 8| 6| 0| 5| 8| 6| 0| 9| 0| 8| 8| 8| 0| 8| 8| 5| 0| 5| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    200 NG/                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cervix, Squamous Cell Carcinoma      |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +        +                          +                              |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Thymoma Malignant, Metastatic,       |                                                                          |             
          Mammary Gland                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                  X        X                              |             
      Carcinoma                            |             X  X                                X              X         |             
      Fibroadenoma                         | X     X        X  X  X           X  X        X     X     X     X         |             
      Fibroadenoma, Multiple               |                               X        X  X     X     X           X  X  X|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Fibroma                              |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 5| 7| 7| 2| 7| 6| 7| 7| 6| 6| 6| 7| 6| 7| 5| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 1| 0| 2| 2| 7| 3| 0| 2| 1| 1| 9| 1| 2| 3| 2| 0| 2| 2| 1| 0| 2| 1| 0|             
                                           | 0| 4| 6| 3| 8| 8| 6| 0| 5| 8| 6| 0| 9| 0| 8| 8| 8| 0| 8| 8| 5| 0| 5| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    200 NG/                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Uterus                          |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 6| 4| 6| 6| 7| 5| 4| 5| 6| 2| 6| 4| 4| 4| 5| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 1| 3| 8| 1| 6| 8| 2| 2| 9| 1| 5| 4| 9| 5| 5| 9| 4| 2| 2| 7| 2| 2| 1|            |
                                           | 9| 9| 9| 0| 0| 3| 7| 9| 8| 5| 1| 2| 1| 0| 2| 1| 1| 5| 7| 9| 8| 6| 9| 8| 5|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Uterus                          |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                                                                      X   |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   2        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gingival, Squamous Cell Carcinoma    |             X                                                        X   |          3 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                      X   |          1 |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Papilloma              |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 6| 4| 6| 6| 7| 5| 4| 5| 6| 2| 6| 4| 4| 4| 5| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 1| 3| 8| 1| 6| 8| 2| 2| 9| 1| 5| 4| 9| 5| 5| 9| 4| 2| 2| 7| 2| 2| 1|            |
                                           | 9| 9| 9| 0| 0| 3| 7| 9| 8| 5| 1| 2| 1| 0| 2| 1| 1| 5| 7| 9| 8| 6| 9| 8| 5|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +     +     +              +     +     +  +        +     +     +  +   |  24        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                                      X   |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Pheochromocytoma Benign              |    X                                                                     |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Adenoma               |    X        X                       X                    X        X     X|         13 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      C-Cell, Adenoma                      |          X                 X                                X            |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 6| 4| 6| 6| 7| 5| 4| 5| 6| 2| 6| 4| 4| 4| 5| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 1| 3| 8| 1| 6| 8| 2| 2| 9| 1| 5| 4| 9| 5| 5| 9| 4| 2| 2| 7| 2| 2| 1|            |
                                           | 9| 9| 9| 0| 0| 3| 7| 9| 8| 5| 1| 2| 1| 0| 2| 1| 1| 5| 7| 9| 8| 6| 9| 8| 5|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Luteoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma                            |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Polyp Stromal                        | X                                            X                           |          4 |
      Cervix, Squamous Cell Carcinoma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Thymoma Malignant, Metastatic,       |                                                                          |            |
          Mammary Gland                    |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                      X   |          5 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 6| 4| 6| 6| 7| 5| 4| 5| 6| 2| 6| 4| 4| 4| 5| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 1| 3| 8| 1| 6| 8| 2| 2| 9| 1| 5| 4| 9| 5| 5| 9| 4| 2| 2| 7| 2| 2| 1|            |
                                           | 9| 9| 9| 0| 0| 3| 7| 9| 8| 5| 1| 2| 1| 0| 2| 1| 1| 5| 7| 9| 8| 6| 9| 8| 5|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroadenoma                         | X        X  X     X  X           X        X  X  X  X  X  X  X           X|         25 |
      Fibroadenoma, Multiple               |       X                                                                  |          9 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basal Cell Carcinoma                 |                            X                                             |          1 |
      Fibroma                              |                      X                                                   |          1 |
      Fibrosarcoma                         |                X                                                         |          1 |
      Sarcoma                              |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Uterus                          |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:22:54    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 6| 4| 6| 6| 7| 5| 4| 5| 6| 2| 6| 4| 4| 4| 5| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 1| 3| 8| 1| 6| 8| 2| 2| 9| 1| 5| 4| 9| 5| 5| 9| 4| 2| 2| 7| 2| 2| 1|            |
                                           | 9| 9| 9| 0| 0| 3| 7| 9| 8| 5| 1| 2| 1| 0| 2| 1| 1| 5| 7| 9| 8| 6| 9| 8| 5|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
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