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TDMS Study 96007-05 Pathology Tables

NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03
Route: GAVAGE                                                                                                     Time: 11:23:31

                                                         FINAL #3/RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57117-31-4

       Lock Date:  07/25/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All



































                                                              Page   1


NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 5| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 0| 2| 0| 7| 3| 2| 5| 2| 2| 2| 2| 2| 5| 2| 7| 5| 1| 9| 2| 7| 2| 2| 2|             
                                           | 0| 7| 0| 8| 0| 5| 6| 9| 4| 8| 9| 8| 8| 8| 1| 8| 8| 2| 5| 9| 9| 8| 9| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 5| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X              X  X         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3                    2     1                              |             
      Basophilic Focus                     |                      X                       X     X                     |             
      Basophilic Focus, Multiple           |                X           X  X                 X     X                 X|             
      Clear Cell Focus                     |                      X              X  X        X                        |             
      Clear Cell Focus, Multiple           |                                  X                          X            |             
      Eosinophilic Focus                   |             X        X                                                   |             
      Eosinophilic Focus, Multiple         |                                           X     X                       X|             
      Fatty Change, Diffuse                |                                  1                                       |             
      Fatty Change, Focal                  |                            1              1  1                           |             
      Hematopoietic Cell Proliferation     |       1           2  1  1  1  1           1        2     1  1            |             
      Hemorrhage                           |    2                                                                     |             
      Hepatodiaphragmatic Nodule           |                                                                X         |             
      Inflammation                         | 1     1  1  2  1  2  1  1  1  1  1  1  1  1        1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     |       X              X                                                   |             
      Mixed Cell Focus, Multiple           |                X           X  X  X     X  X  X  X           X  X  X     X|             
      Necrosis                             |    2        3     2     3                                                |             
      Pigmentation                         |                         1                    1        1     1            |             
      Bile Duct, Cyst                      |                                     2           2                        |             
      Bile Duct, Fibrosis                  |                                                                      1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 5| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 0| 2| 0| 7| 3| 2| 5| 2| 2| 2| 2| 2| 5| 2| 7| 5| 1| 9| 2| 7| 2| 2| 2|             
                                           | 0| 7| 0| 8| 0| 5| 6| 9| 4| 8| 9| 8| 8| 8| 1| 8| 8| 2| 5| 9| 9| 8| 9| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 5| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                         1|             
      Centrilobular, Degeneration          | 2                 2                                2  2                  |             
      Hepatocyte, Hypertrophy              |                                                                          |             
      Oval Cell, Hyperplasia               |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis                        |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Gingival, Hyperplasia, Squamous      |       1  1           1        1        1        1           2  1         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             1            |             
      Acinus, Atrophy                      |                                                             2            |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |          2                             2                                2|             
      Inflammation                         |                                                                         2|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                    2                     |             
      Mineralization                       |                1                                                         |             
      Ulcer                                |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +  +  +     +  +        +  +  +  +        +           +  +  +  +   |             
      Peridontal Tissue, Inflammation      | 2     2  2  2     2  1        2  1  1  2        2           2  2  3  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             1                 1        1              1              1  1|             
      Hemorrhage                           |    2              2                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 5| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 0| 2| 0| 7| 3| 2| 5| 2| 2| 2| 2| 2| 5| 2| 7| 5| 1| 9| 2| 7| 2| 2| 2|             
                                           | 0| 7| 0| 8| 0| 5| 6| 9| 4| 8| 9| 8| 8| 8| 1| 8| 8| 2| 5| 9| 9| 8| 9| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 5| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Inflammation                         |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1     2     3     2  2  2  1  2  1  1                 1     2  1|             
      Atrophy                              |                                                       4                  |             
      Degeneration, Cystic                 |                                        2                       1         |             
      Hemorrhage                           |                                                       4                  |             
      Hyperplasia                          |                      3     2                                         2   |             
      Hypertrophy                          |    1  2  1  1  1  1  1  2  1  2  2     3  2     2        2  3  2  1  1  1|             
      Necrosis                             |             2                             2        3                    2|             
      Vacuolization Cytoplasmic            |          1        1                       1                 2  2     2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  3           2                                            2     2|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          3     1     2        2  1  2           1        1  1        2   |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                      2                                1                  |             
      Cytoplasmic Alteration               |                                                                   1      |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           |                2     3     3     2     3  2  2                 3  2      |             
      Pars Intermedia, Hyperplasia         |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   3                             1           3     1  2   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hypertrophy         |                2                                                  2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 5| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 0| 2| 0| 7| 3| 2| 5| 2| 2| 2| 2| 2| 5| 2| 7| 5| 1| 9| 2| 7| 2| 2| 2|             
                                           | 0| 7| 0| 8| 0| 5| 6| 9| 4| 8| 9| 8| 8| 8| 1| 8| 8| 2| 5| 9| 9| 8| 9| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 5| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1  2  1  2  2  1  1  2  2  1  2  2  2  1  1     1  2  2  1  1  3  3|             
      Duct, Cyst                           | 2     1  3  3  2  2  2  2  2  3  2  2  2  3  3  2     2  2     2     2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4     4  4  4  4  4  4        4     3  4  4  4  4     4  4  4   |             
      Cyst                                 |                         2           2        2     2              3      |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Suppurative            |                   2                                                      |             
      Metaplasia, Squamous                 |       2        2        2                    1  2  2                 2   |             
      Endometrium, Hyperplasia, Cystic     | 4     2  3     2  2        3        1  3     3  3  1  2  1        3  2   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  4  2  4     3     3        2        2     3  2  2  3     4     2  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                            +                    +                        |             
      Lumbar, Ectasia                      |                                                 2                        |             
      Lumbar, Hemorrhage                   |                            3                                             |             
      Popliteal, Ectasia                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |          3           2     2  2  2  2  2  2  2     2  2  2  2  2  2  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 5| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 0| 2| 0| 7| 3| 2| 5| 2| 2| 2| 2| 2| 5| 2| 7| 5| 1| 9| 2| 7| 2| 2| 2|             
                                           | 0| 7| 0| 8| 0| 5| 6| 9| 4| 8| 9| 8| 8| 8| 1| 8| 8| 2| 5| 9| 9| 8| 9| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 5| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Accessory Spleen                     |                                                                          |             
      Hematopoietic Cell Proliferation     |    1  2  1  3  1  4  2  2  2  1  2  2  2  3  2  1  3  3  3  2  2  1  2  3|             
      Pigmentation                         | 3  2  1  2  1  1  1  2  1  2  3  2  2  2  1  1  1  1  2  2  2  2  1  3  2|             
      Lymphoid Follicle, Atrophy           | 2                       2                       1              2         |             
      Red Pulp, Atrophy                    | 2                                                                 2      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2     2  3  2  2  2     3  2  3     2  2  2  2  2  3  2  3     3  3  1|             
      Hemorrhage                           | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 1        2  1  1     1        1  2  2  1  1           1  1  1  1  2  1   |             
      Inflammation, Granulomatous          |                                                                1  2      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                         3|             
      Ulcer                                |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    3                                                                     |             
      Hydrocephalus                        |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1     1  2     2  1  2  2  2  2  1  2     2        1  2     2  1  2  2  1|             
      Inflammation                         |    1           2           1                                             |             
      Alveolar Epithelium, Hyperplasia     |                            1  1     2                                1  1|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 5| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 0| 2| 0| 7| 3| 2| 5| 2| 2| 2| 2| 2| 5| 2| 7| 5| 1| 9| 2| 7| 2| 2| 2|             
                                           | 0| 7| 0| 8| 0| 5| 6| 9| 4| 8| 9| 8| 8| 8| 1| 8| 8| 2| 5| 9| 9| 8| 9| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 5| 1| 2| 3| 4| 5| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
           Bronchiolar                     |          1                                                               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1        1                 1     1           1  1         |             
      Mineralization                       |                                                    1                     |             
      Respiratory Epithelium, Hyperplasia  |                         2                                                |             
      Septum, Inflammation                 |                                                    1                     |             
      Squamous Epithelium, Hyperplasia     |                                                          1               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               1              1  1           1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                  X                       X               |             
      Inflammation, Suppurative            |                                     1                                    |             
      Mineralization                       | 1        1  1  1  1     1     1        1     1              1  1  1  1   |             
      Nephropathy                          |    1     2        1  2        1  1  1     1  1        1        1  1  2  1|             
      Pigmentation                         |                                                             2            |             
      Capsule, Hemorrhage                  |                                                       3                  |             
      Pelvis, Inflammation                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 7| 7| 7| 6| 3| 6| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 2| 2| 2| 7| 2| 5| 3| 1| 7| 2| 8| 1| 2| 2| 2| 5| 2| 0| 3| 3| 1| 2|             
                                           | 9| 5| 9| 9| 9| 9| 8| 1| 1| 0| 3| 8| 0| 8| 9| 9| 8| 9| 9| 8| 3| 0| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 4| 6| 7| 9| 0| 2| 3| 4| 7| 9| 0| 1| 2| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                                |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1              1                                                  1   |             
      Basophilic Focus                     |    X     X              X                                   X        X   |             
      Basophilic Focus, Multiple           |             X     X        X  X  X                 X                     |             
      Clear Cell Focus                     |    X           X     X     X     X                 X              X      |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   | X                                                     X     X  X        X|             
      Eosinophilic Focus, Multiple         |    X     X                                                           X   |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                                 2  1                     |             
      Hematopoietic Cell Proliferation     | 1        1           1     1  1  1     1  1           1        1  1  1   |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                              X                          X|             
      Inflammation                         | 1  1  3  1  1  2     1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1|             
      Mixed Cell Focus                     |                         X     X                                          |             
      Mixed Cell Focus, Multiple           |    X     X  X  X           X     X     X     X  X  X     X     X  X  X  X|             
      Necrosis                             |                                                                          |             
      Pigmentation                         |    1  2     1  1     1              1              1                    1|             
      Bile Duct, Cyst                      |    3                    3                                3              2|             
      Bile Duct, Fibrosis                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 7| 7| 7| 6| 3| 6| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 2| 2| 2| 7| 2| 5| 3| 1| 7| 2| 8| 1| 2| 2| 2| 5| 2| 0| 3| 3| 1| 2|             
                                           | 9| 5| 9| 9| 9| 9| 8| 1| 1| 0| 3| 8| 0| 8| 9| 9| 8| 9| 9| 8| 3| 0| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 4| 6| 7| 9| 0| 2| 3| 4| 7| 9| 0| 1| 2| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Hyperplasia               |       2                                                                  |             
      Centrilobular, Degeneration          |                                                                          |             
      Hepatocyte, Hypertrophy              |    1                    1                                                |             
      Oval Cell, Hyperplasia               |          1                                                               |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |    1  1                                         1        1  1     1      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        1                                 |             
      Acinus, Atrophy                      |       1                                2                                 |             
      Artery, Inflammation, Chronic Active |       1                                                                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2                                             |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                | 1                                                                        |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                          1               |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +           +        +  +  +     +     +  +  +  +  +      |             
      Peridontal Tissue, Inflammation      | 1  1  2  1  1  1           2        2  3  1     2     1  2  1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1  1        2                                1                    1|             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 7| 7| 7| 6| 3| 6| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 2| 2| 2| 7| 2| 5| 3| 1| 7| 2| 8| 1| 2| 2| 2| 5| 2| 0| 3| 3| 1| 2|             
                                           | 9| 5| 9| 9| 9| 9| 8| 1| 1| 0| 3| 8| 0| 8| 9| 9| 8| 9| 9| 8| 3| 0| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 4| 6| 7| 9| 0| 2| 3| 4| 7| 9| 0| 1| 2| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2        1  1  2     2  1     1  2  1     2  1  2     1        1  1  1|             
      Atrophy                              |       4                                                                  |             
      Degeneration, Cystic                 |                                              3              2            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                            1           2              3        2         |             
      Hypertrophy                          |          2  1  2  3     2  2  1  1  2  1     3  2  2     1  3  2  3  1  1|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |    1                                                           1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                       3        2                       3  3|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                1  2     2  1        3        3     2     3     3         |             
      Atrophy                              |       4                                                                  |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Vacuolization Cytoplasmic            |                                           1        1                     |             
      Pars Distalis, Hyperplasia           |          2  2              3              2     2  2  2           3  2  2|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                               2                 2  2  2     2  2  3      |             
      Follicle, Cyst                       |                                                                         2|             
      Follicular Cell, Hypertrophy         |    2           1  2     1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 7| 7| 7| 6| 3| 6| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 2| 2| 2| 7| 2| 5| 3| 1| 7| 2| 8| 1| 2| 2| 2| 5| 2| 0| 3| 3| 1| 2|             
                                           | 9| 5| 9| 9| 9| 9| 8| 1| 1| 0| 3| 8| 0| 8| 9| 9| 8| 9| 9| 8| 3| 0| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 4| 6| 7| 9| 0| 2| 3| 4| 7| 9| 0| 1| 2| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  3  4  2  2  2  2  2  2  1  2  3  3  1  1  2  1  1  1  1  1  2  3  2  1|             
      Duct, Cyst                           | 2  3  2  2  3  2  3  2  3     2  1  3  3     2  1        2     4     2  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  4  4     4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4  4     4|             
      Cyst                                 |          3  2                       2              2              2      |             
      Inflammation, Chronic Active         |                                                 4                        |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                         +                                                |             
      Cyst                                 |                         3                                                |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Suppurative            |                                                 2                       1|             
      Metaplasia, Squamous                 |             1     3  1     1              2     1     4  1        2     2|             
      Endometrium, Hyperplasia, Cystic     |       1  4     3        3  3  1  3     3  2  3     3     1  3           3|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  2  2  4        3  4     3  3  3  2  3  4     2  2  3  2  2  3     3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                    +                                             |             
      Lumbar, Ectasia                      |                                                                          |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Popliteal, Ectasia                   |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |    2  2     2  2  2  2  3  3  2  2        2  1  2  3     2     2  2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 7| 7| 7| 6| 3| 6| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 2| 2| 2| 7| 2| 5| 3| 1| 7| 2| 8| 1| 2| 2| 2| 5| 2| 0| 3| 3| 1| 2|             
                                           | 9| 5| 9| 9| 9| 9| 8| 1| 1| 0| 3| 8| 0| 8| 9| 9| 8| 9| 9| 8| 3| 0| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 4| 6| 7| 9| 0| 2| 3| 4| 7| 9| 0| 1| 2| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Accessory Spleen                     |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  2     2  1  1  2  2  2  2  3  2     2  2  2  2  2     1  2  2  2  3  2|             
      Pigmentation                         | 1  2  3     3  2  2  1  1  1  1  2  3  1  1  2  2  2  1  2  2  1  2  1  2|             
      Lymphoid Follicle, Atrophy           |                               2                       3                 2|             
      Red Pulp, Atrophy                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  2  2  3  2  2     3  2  2  3  3     2     3  2     2  2  2  3  3  2|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     3                                    |             
      Hyperplasia                          | 1  1     1  1           2  2     1  2  1     1  2  1     1        1  2  1|             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       3                                                                  |             
      Ulcer                                |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1  2  1  1  2  1  1  2  2  2  2  2  1  2  2  2  2     2  2  2  2  2  2|             
      Inflammation                         |       2                             1                                    |             
      Alveolar Epithelium, Hyperplasia     |             1  1           1              1  1     1           1     1  1|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 6| 7| 7| 7| 6| 3| 6| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 2| 2| 2| 7| 2| 5| 3| 1| 7| 2| 8| 1| 2| 2| 2| 5| 2| 0| 3| 3| 1| 2|             
                                           | 9| 5| 9| 9| 9| 9| 8| 1| 1| 0| 3| 8| 0| 8| 9| 9| 8| 9| 9| 8| 3| 0| 0| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 4| 6| 7| 9| 0| 2| 3| 4| 7| 9| 0| 1| 2| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
           Bronchiolar                     |                            1                                      1     1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      2                                   1               |             
      Mineralization                       |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Septum, Inflammation                 |                                                                          |             
      Squamous Epithelium, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                  1  1              1           1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                            X                                             |             
      Inflammation, Suppurative            |                                           1                              |             
      Mineralization                       | 1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1      |             
      Nephropathy                          |    1  1     1  1        1  1     1  1  1  1  1  1  2     1     1     1  1|             
      Pigmentation                         |       2                                                                  |             
      Capsule, Hemorrhage                  |                                                                          |             
      Pelvis, Inflammation                 |             2                                                            |             
      Transitional Epithelium, Hyperplasia |                            1                                             |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    3        2                                                            |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      6  1.5|
      Basophilic Focus                     | X     X                                                                  |     10     |
      Basophilic Focus, Multiple           |                                                                          |     12     |
      Clear Cell Focus                     |                                                                          |     11     |
      Clear Cell Focus, Multiple           |                                                                          |      2     |
      Eosinophilic Focus                   |                                                                          |      7     |
      Eosinophilic Focus, Multiple         | X  X                                                                     |      8     |
      Fatty Change, Diffuse                |                                                                          |      1  1.0|
      Fatty Change, Focal                  |                                                                          |      5  1.2|
      Hematopoietic Cell Proliferation     |    1  1                                                                  |     24  1.1|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Inflammation                         | 1  1                                                                     |     47  1.1|
      Mixed Cell Focus                     | X                                                                        |      5     |
      Mixed Cell Focus, Multiple           |       X                                                                  |     28     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Necrosis                             |                                                                          |      4  2.5|
      Pigmentation                         |    1                                                                     |     13  1.1|
      Bile Duct, Cyst                      | 1                                                                        |      7  2.3|
      Bile Duct, Fibrosis                  |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |    1                                                                     |      3  1.3|
      Centrilobular, Degeneration          |                                                                          |      4  2.0|
      Hepatocyte, Hypertrophy              |                                                                          |      2  1.0|
      Oval Cell, Hyperplasia               |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  52        |
      Gingival, Hyperplasia, Squamous      | 1                                                                        |     15  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Acinus, Atrophy                      |                                                                          |      3  1.7|
      Artery, Inflammation, Chronic Active |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      4  1.8|
      Inflammation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.0|
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +                                                                     |  33        |
      Peridontal Tissue, Inflammation      | 2  1                                                                     |     33  1.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       | 1  1  1                                                                  |     15  1.1|
      Hemorrhage                           |                                                                          |      2  2.0|
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 1  2                                                                     |     31  1.5|
      Atrophy                              | 2                                                                        |      3  3.3|
      Degeneration, Cystic                 |                                                                          |      4  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          |    4                                                                     |      8  2.4|
      Hypertrophy                          | 1  3  2                                                                  |     42  1.7|
      Necrosis                             |                                                                          |      4  2.3|
      Vacuolization Cytoplasmic            |    2                                                                     |      9  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |       2                                                                  |     11  2.3|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |    1                                                                     |     20  1.9|
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      2  1.5|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  1.0|
      Pars Distalis, Hyperplasia           | 2  3  4                                                                  |     22  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  | 3  2  2                                                                  |     15  2.1|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hypertrophy         |       1                                                                  |      7  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 2  1  1                                                                  |     52  1.7|
      Duct, Cyst                           | 3                                                                        |     40  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4  4                                                                  |     43  4.0|
      Cyst                                 | 2                                                                        |     11  2.2|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenomyosis                          | 2                                                                        |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      3  1.7|
      Metaplasia, Squamous                 |                                                                          |     17  1.8|
      Endometrium, Hyperplasia, Cystic     | 3     1                                                                  |     31  2.4|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          |    3  3                                                                  |     38  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   5        |
      Lumbar, Ectasia                      |       2                                                                  |      2  2.0|
      Lumbar, Hemorrhage                   |       2                                                                  |      2  2.5|
      Popliteal, Ectasia                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Hyperplasia, Plasma Cell             | 3  2  2                                                                  |     38  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Hemorrhage                           |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Accessory Spleen                     | X                                                                        |      1     |
      Hematopoietic Cell Proliferation     | 2  2  2                                                                  |     49  2.0|
      Pigmentation                         | 2  2  1                                                                  |     52  1.7|
      Lymphoid Follicle, Atrophy           |                                                                          |      7  2.0|
      Red Pulp, Atrophy                    |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  53        |
      Atrophy                              | 2  2  1                                                                  |     43  2.3|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          |    2                                                                     |     33  1.3|
      Inflammation, Granulomatous          |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Ulcer                                |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 2     1                                                                  |     44  1.7|
      Inflammation                         |                                                                          |      5  1.4|
      Alveolar Epithelium, Hyperplasia     |                                                                          |     14  1.1|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 1                                                                        |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      8  1.1|
      Mineralization                       |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Septum, Inflammation                 |                                                                          |      1  1.0|
      Squamous Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 2| 2|                                                                 |            |
                                           | 0| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         | 1     1                                                                  |     16  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      | X  X                                                                     |      5     |
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Mineralization                       | 1  1  1                                                                  |     37  1.0|
      Nephropathy                          | 1  1  1                                                                  |     34  1.1|
      Pigmentation                         |                                                                          |      2  2.0|
      Capsule, Hemorrhage                  |                                                                          |      1  3.0|
      Pelvis, Inflammation                 |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia | 1                                                                        |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                    X                     |             
      Muscularis, Inflammation             |    1                                            2                        |             
      Periesophageal Tissue, Inflammation  |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                             X                        |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1                                                   |             
      Basophilic Focus                     |       X           X                       X     X                 X     X|             
      Basophilic Focus, Multiple           |                X                 X                          X            |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |                                                             X            |             
      Clear Cell Focus, Multiple           |                      X           X                                       |             
      Eosinophilic Focus                   |             X  X     X                       X                           |             
      Eosinophilic Focus, Multiple         |                                                          X               |             
      Fatty Change, Diffuse                |                   1                                                     1|             
      Fatty Change, Focal                  |                                           1        2                     |             
      Hematopoietic Cell Proliferation     |    1                    1  1  1        1     1  2        1  1  1  1      |             
      Hepatodiaphragmatic Nodule           |                                                                X         |             
      Inflammation                         | 1  1  1     1  1  1  1  2  1  2  1  1  1  1  1           1  1        1  1|             
      Mixed Cell Focus, Multiple           | X  X              X  X     X     X  X     X     X        X  X            |             
      Necrosis                             |                         3     2        1              2                  |             
      Pigmentation                         | 1                    1           1                       1     1        1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Toxic Hepatopathy                    |                                                 1                        |             
      Bile Duct, Cyst                      |          1                                                  2            |             
      Bile Duct, Fibrosis                  |                                                 2        1               |             
      Bile Duct, Hyperplasia               |                                                          1               |             
      Centrilobular, Degeneration          |                               2                                          |             
      Hepatocyte, Hypertrophy              |          1  1                                1  1                 1      |             
      Oval Cell, Hyperplasia               |             1                                   1                        |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation                         |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |          2     2           1                                      2      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Inflammation                   |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            1                 1  1                 1      |             
      Serosa, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +     +     +  +  +     +        +  +        +     +     +  +  +      |             
      Peridontal Tissue, Inflammation      |    1     2     2  3  2     1        1  2        1     1     2  1  1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                   1  1           1        1                          1   |             
      Epicardium, Inflammation             |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1  2  1  1  1  1  2     1     1  1     2        1     2  2  1  1  1  1|             
      Degeneration, Cystic                 | 1        1  1     3        1     2                                      2|             
      Hyperplasia                          | 2                                                           2            |             
      Hypertrophy                          | 2  2  1  2  2     3  2     2     3  1     1  1  1        1  1  2  2  2  3|             
      Vacuolization Cytoplasmic            |                                                                   1     1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2              2                             1                       3|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2     1     3                    3                       3  3  2  3  3|             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           |       4           2  2     1     2              3        2               |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2        2  1  2     1                       3           2        2   |             
      Follicular Cell, Hypertrophy         |    1                                            1                       1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Inflammation                         | 1  2  2  2  2  3  3  2  1  1  1  2  2  2  2  1  2  1  2  2     2  2     1|             
      Duct, Cyst                           | 2  2  1  1  3  3  3  2  2  3  2  3     3     2  3  2  2  2     2  2     3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4     4  4  4  4        3           4  4  4  4  4|             
      Cyst                                 | 2        2                             2  3           2     2        2   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          3               |             
      Inflammation, Chronic Active         |                                        2        2                        |             
      Inflammation, Suppurative            |                   2  1              1                                    |             
      Metaplasia, Squamous                 |          1  1  1  1           1        4        4           1     2  2   |             
      Endometrium, Hyperplasia, Cystic     | 2  3  2  2  2        2        1     2                    1        1  2  1|             
                                           |__________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3        2           4     3     2  4     3  4     3     2  3  3     2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                              +        +                  |             
      Iliac, Ectasia                       |                                              3                           |             
      Lumbar, Ectasia                      |                                                                          |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   2                                                      |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Plasma Cell             | 2  2  3  1  2     3  2  3  2  3  2  2           2        2  3     3  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  1  1  2  2  3  2  4  2  2  2  2  3  3  1     2  2  3  3  1  2|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 2  1  2  1  2  2  2  3  1  1     2  2  1  2        2     2  2  2  1  2  2|             
      Lymphoid Follicle, Atrophy           |                2                       2                       3         |             
      Red Pulp, Hyperplasia                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              | 2  2  2  2  2     2  2  3  3     3     3  2        2        2     4  2  2|             
      Inflammation                         |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3                                                         |             
      Hyperplasia                          |    2        1  1     1     2                 1     1  1  2     1  1  1  1|             
      Inflammation, Granulomatous          |                1                                                        3|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                         3|             
      Ulcer                                |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  1     2  3  2  2  2  2  1     2  1  1  1     2     2  2  2  2  2  1  2|             
      Inflammation                         |    1                 1                                   2     2        2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1           1     1  1           1        1                       1      |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |          1        1                             1        1               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1                                                      |             
      Respiratory Epithelium, Hyperplasia  |             1                                                            |             
      Septum, Inflammation                 |                   1           1                                          |             
      Squamous Epithelium, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation    |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           3                              |             
      Inflammation                         |                   3                                                      |             
      Lens, Degeneration                   |                                           3                              |             
      Retina, Degeneration                 |                                           3                              |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1  1  1  1                          1           1            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                            1                                             |             
      Calculus Micro Observation Only      |                                  X                                       |             
      Inflammation, Suppurative            |                                           1                              |             
      Mineralization                       | 1  1  1  1  1  1     1  1  1  1  1  1  1  1     1  1     1  1  1  1     1|             
      Nephropathy                          | 1  2  1     1  1  2  1     1  1  1  1  1  1              1        2  1  2|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                                                                          |             
      Renal Tubule, Necrosis               |                                                                   2      |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 6| 7| 7| 4| 5| 4| 7| 7| 5| 7| 3| 6| 2| 6| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 6| 5| 4| 0| 2| 3| 8| 2| 3| 3| 3| 2| 9| 2| 9| 3| 2| 2| 0| 5| 8| 8|             
                                           | 0| 0| 8| 8| 1| 5| 6| 8| 2| 7| 0| 0| 0| 0| 8| 3| 4| 6| 5| 8| 9| 0| 1| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 7| 9| 0| 1| 2| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         1                                                |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
      Muscularis, Inflammation             |                                                                          |             
      Periesophageal Tissue, Inflammation  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                            X         |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                    1      |             
      Basophilic Focus                     |    X                             X     X                    X            |             
      Basophilic Focus, Multiple           | X              X           X        X              X  X        X  X  X   |             
      Cholangiofibrosis                    |                            1                                             |             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |    X  X                    X                                             |             
      Eosinophilic Focus                   |             X           X     X              X     X           X         |             
      Eosinophilic Focus, Multiple         | X                                                                        |             
      Fatty Change, Diffuse                |                                        2  1                              |             
      Fatty Change, Focal                  | 4  3                                                        1            |             
      Hematopoietic Cell Proliferation     | 1     1  1     2  1  1  2              2  1  1  1  1  2  2     1        2|             
      Hepatodiaphragmatic Nodule           |             X  X                                                         |             
      Inflammation                         |    1  1  2  1  1  1  1  2  1  1  1     1  1  1  2  1  1  1  1  2     1  2|             
      Mixed Cell Focus, Multiple           | X  X  X        X     X     X  X     X        X     X              X      |             
      Necrosis                             |             2           3     2                 2              2        2|             
      Pigmentation                         |          1                                   1        1                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Toxic Hepatopathy                    |                                                                          |             
      Bile Duct, Cyst                      |                      3        3                                          |             
      Bile Duct, Fibrosis                  |                2                    2                                    |             
      Bile Duct, Hyperplasia               |          1                                                               |             
      Centrilobular, Degeneration          | 1                                                                        |             
      Hepatocyte, Hypertrophy              | 1        1           1                    1                    1  1     1|             
      Oval Cell, Hyperplasia               |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Inflammation                         |                                  2                                       |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      | 1     1           1           1                    2           1         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  2                                       |             
      Acinus, Atrophy                      |                                  4                                       |             
      Acinus, Hyperplasia                  |       3                                                                  |             
      Artery, Inflammation, Chronic Active |                                                          2               |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Inflammation                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        2                                 |             
      Hyperplasia, Squamous                |                                                 1                        |             
      Inflammation                         |                                        1                                 |             
      Ulcer                                |                                        1                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1  1     1     1        2                                                |             
      Serosa, Inflammation                 |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +        +  +           +     +  +     +     +  +           +  +   |             
      Peridontal Tissue, Inflammation      | 1     2        1  1           1     2  1     1     2  1           2  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1                                1  1  1        1                     |             
      Epicardium, Inflammation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  2  2        1     2  1  2  1     1        2     1  2     1  1  1  2   |             
      Degeneration, Cystic                 |                2     3           3           2        2  1     3  2     2|             
      Hyperplasia                          |       2           2  2                       2                    2     2|             
      Hypertrophy                          | 1  2  2        3  2  3     2  2  2  2  1  1  3  1  1  2  2  1  3  3  2  2|             
      Vacuolization Cytoplasmic            |       1  1     1     3        2  1     1                    1  1  1      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2        3  2        3        2                 1           2      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
      Hypertrophy                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  3           3              3           2  3        2        2     3   |             
      Vacuolization Cytoplasmic            |                                     1  1                                 |             
      Pars Distalis, Hyperplasia           |    3              3  3  2  2           2        3              3         |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2        3              2           2  2     2        4              3   |             
      Follicular Cell, Hypertrophy         |          1     1  1                       1  1                 1  1     3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  3  2  2  1  1  2  2  1  3     1  2  2  2     1  3  1  1  2  2      |             
      Duct, Cyst                           | 1     2  2     3  2     2     2           3        2  3  3  2     3  2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4           4  4  4  4  4  4  4     4  4  4  4  4  4     4        4  4  4|             
      Cyst                                 |    2     2     2  2     2  3                    3     2  2     1         |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |          2                       3                       4               |             
      Inflammation, Suppurative            |                               1     1  2                                 |             
      Metaplasia, Squamous                 |          2  2  1  2  1           4  2  3  1           1           1  1  1|             
      Endometrium, Hyperplasia, Cystic     | 2        4  2  2  1  2  2     3     2     1  3  4     3           2     2|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        3  3  3  4     3        3  2  3  2     4  3  3  4  2     2     3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                 +        +               |             
      Iliac, Ectasia                       |                                                                          |             
      Lumbar, Ectasia                      |                                                          3               |             
      Lumbar, Hemorrhage                   |                                                          2               |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                 3                        |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                          3               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Histiocytic             |                                                 2                        |             
      Hyperplasia, Plasma Cell             | 2  2  2        2     3     2  2     2  2  2  3     2  2  2  3  2  2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                          3               |             
      Hyperplasia, Plasma Cell             |                                                          2               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2  2  3  2  2  3  2  3  2  2  2  2  2  2  2  3  3  3     2  3  1     4|             
      Hemorrhage                           |                                                          2               |             
      Necrosis                             |                                                          3               |             
      Pigmentation                         | 1  2  2  1  2  2  1     1  3  2  1  1  2  1  1  1  1  2     2     2  2  1|             
      Lymphoid Follicle, Atrophy           |          2              2        2     2                                2|             
      Red Pulp, Hyperplasia                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Atrophy                              |       2        3  2  2  4     3  3  2  3  3  3  4  4  4  2  2  2         |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    2                     |             
      Hyperplasia                          |    1  2        1  1  2     1     1  1  1  2        1  2     1  2  2      |             
      Inflammation, Granulomatous          |                         2  3                                             |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2  1  1     1  2  2  2  1  1  2  2  1  1     2     2  2     1  2  2  2|             
      Inflammation                         |                         1           1     1                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1  1              1  1  2  1                          1        2  1  1|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |                1                    1                                    |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                2                             1                           |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Septum, Inflammation                 |                                                                          |             
      Squamous Epithelium, Hyperplasia     |                2                                                         |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Lens, Degeneration                   |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1              1                                            1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Calculus Micro Observation Only      |    X                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1           1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1|             
      Nephropathy                          |    1  1  1  1  2     1  1  1  1  1  1  1  1  1  1     1     1  1     1   |             
      Pelvis, Dilatation                   |                                                 3                        |             
      Pelvis, Inflammation                 |                   2                                                      |             
      Renal Tubule, Necrosis               |                                                                          |             
      Transitional Epithelium, Hyperplasia |                   2                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 2| 7| 4| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 7| 7| 4| 3| 6| 7| 6| 6|             
                             DAY ON TEST   | 5| 3| 2| 0| 8| 2| 9| 2| 4| 2| 2| 1| 2| 2| 2| 2| 6| 3| 0| 5| 2| 6| 2| 6| 9|             
                                           | 1| 0| 9| 3| 9| 8| 8| 8| 7| 9| 8| 6| 8| 6| 8| 8| 7| 0| 7| 1| 1| 7| 9| 5| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 NG/KG                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   2                             2                        |             
      Transitional Epithelium, Hyperplasia |                   2                                                      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    6 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Perforation                          |                                                                          |      1     |
      Muscularis, Inflammation             |                                                                          |      2  1.5|
      Periesophageal Tissue, Inflammation  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    | X                                                                        |      5     |
      Artery, Inflammation, Chronic Active |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
      Artery, Inflammation, Chronic Active |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      3  1.3|
      Basophilic Focus                     | X                                                                        |     11     |
      Basophilic Focus, Multiple           |                                                                          |     12     |
      Cholangiofibrosis                    |                                                                          |      1  1.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Clear Cell Focus, Multiple           |                                                                          |      5     |
      Eosinophilic Focus                   |       X                                                                  |     11     |
      Eosinophilic Focus, Multiple         |                                                                          |      2     |
      Fatty Change, Diffuse                |                                                                          |      4  1.3|
      Fatty Change, Focal                  |    1                                                                     |      6  2.0|
      Hematopoietic Cell Proliferation     | 1                                                                        |     28  1.3|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    6 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         | 1  1  2                                                                  |     44  1.2|
      Mixed Cell Focus, Multiple           | X  X                                                                     |     24     |
      Necrosis                             |                                                                          |     10  2.1|
      Pigmentation                         | 1     2                                                                  |     11  1.1|
      Toxic Hepatopathy                    |       1                                                                  |      2  1.0|
      Bile Duct, Cyst                      |                                                                          |      4  2.3|
      Bile Duct, Fibrosis                  |                                                                          |      4  1.8|
      Bile Duct, Hyperplasia               |                                                                          |      2  1.0|
      Centrilobular, Degeneration          |                                                                          |      2  1.5|
      Hepatocyte, Hypertrophy              |    1                                                                     |     13  1.0|
      Oval Cell, Hyperplasia               |    1  2                                                                  |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   2        |
      Inflammation                         |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Hyperplasia, Squamous      |       1                                                                  |     11  1.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      1  4.0|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |       2                                                                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
      Duct, Inflammation                   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    6 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      9  1.1|
      Serosa, Inflammation                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  25        |
      Peridontal Tissue, Inflammation      |                                                                          |     25  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       | 1     1                                                                  |     12  1.0|
      Epicardium, Inflammation             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 1  2                                                                     |     37  1.4|
      Degeneration, Cystic                 |    1                                                                     |     17  1.9|
      Hyperplasia                          | 2     2                                                                  |     10  2.0|
      Hypertrophy                          |    3  2                                                                  |     43  1.9|
      Vacuolization Cytoplasmic            |       1                                                                  |     13  1.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |       3                                                                  |     12  2.2|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  51        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    6 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |    3  2                                                                  |     21  2.5|
      Vacuolization Cytoplasmic            |                                                                          |      2  1.0|
      Pars Distalis, Hyperplasia           | 1                                                                        |     16  2.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  |                                                                          |     16  2.2|
      Follicular Cell, Hypertrophy         | 1     1                                                                  |     13  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  51        |
      Inflammation                         | 2  2  2                                                                  |     47  1.8|
      Duct, Cyst                           |    2  2                                                                  |     37  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4  4                                                                  |     40  4.0|
      Cyst                                 |    2                                                                     |     18  2.1|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      5  2.6|
      Inflammation, Suppurative            |                                                                          |      6  1.3|
      Metaplasia, Squamous                 | 2  3                                                                     |     25  1.8|
      Endometrium, Hyperplasia, Cystic     | 3  1                                                                     |     29  2.1|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    6 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia                          | 3     3                                                                  |     32  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
      Iliac, Ectasia                       |                                                                          |      1  3.0|
      Lumbar, Ectasia                      |                                                                          |      1  3.0|
      Lumbar, Hemorrhage                   |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 2  3  2                                                                  |     40  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Congestion                           |       2                                                                  |      1  2.0|
      Hematopoietic Cell Proliferation     | 2  2                                                                     |     49  2.2|
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         | 1  2                                                                     |     45  1.6|
      Lymphoid Follicle, Atrophy           |                                                                          |      8  2.1|
      Red Pulp, Hyperplasia                |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  49        |
      Atrophy                              | 3     3                                                                  |     36  2.6|
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    6 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Cyst                                 |                                                                          |      2  2.5|
      Hyperplasia                          |       2                                                                  |     29  1.3|
      Inflammation, Granulomatous          |                                                                          |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 2  1                                                                     |     44  1.7|
      Inflammation                         |                                                                          |      8  1.4|
      Alveolar Epithelium, Hyperplasia     |                                                                          |     17  1.1|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |                                                                          |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      3  1.3|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|
      Septum, Inflammation                 |                                                                          |      2  1.0|
      Squamous Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
      Peritracheal Tissue, Inflammation    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7|                                                                 |            |
                             DAY ON TEST   | 4| 3| 2|                                                                 |            |
                                           | 7| 0| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    6 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
      Lens, Degeneration                   |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      9  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  1.0|
      Calculus Micro Observation Only      |                                                                          |      2     |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       | 1  1  1                                                                  |     45  1.0|
      Nephropathy                          | 1  1  2                                                                  |     39  1.2|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Pelvis, Inflammation                 |                                                                          |      1  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |       1                                                                  |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      3  1.7|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 2| 2| 7| 5| 7| 7| 7| 6| 7| 4| 4| 7| 6| 7| 7| 5| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 8| 3| 1| 4| 3| 6| 2| 2| 2| 0| 3| 9| 2| 2| 7| 2| 2| 8| 9| 3| 2| 1| 8|             
                                           | 9| 8| 4| 0| 9| 6| 0| 1| 8| 8| 8| 5| 0| 7| 0| 9| 5| 8| 9| 6| 3| 0| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
      Muscularis, Inflammation             |                                                             1            |             
      Periesophageal Tissue, Inflammation  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X              X                 X                       X            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                     2  2      |             
      Basophilic Focus                     |                                                                X         |             
      Basophilic Focus, Multiple           |          X                             X           X  X  X  X           X|             
      Clear Cell Focus                     | X                          X        X        X        X        X         |             
      Clear Cell Focus, Multiple           |                   X                                                      |             
      Eosinophilic Focus                   |          X                       X                             X         |             
      Eosinophilic Focus, Multiple         |       X              X                          X  X                 X  X|             
      Fatty Change, Diffuse                | 1              1  1                                      2               |             
      Fatty Change, Focal                  |    1                                                                     |             
      Hematopoietic Cell Proliferation     | 1     1        1     1     1  1        1     1  1  1        1  1     1   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation                         | 2  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  2  1  1|             
      Mixed Cell Focus                     |                                                 X                        |             
      Mixed Cell Focus, Multiple           | X  X     X        X     X  X  X     X        X     X  X        X     X  X|             
      Necrosis                             |    1                                                              2      |             
      Pigmentation                         | 1  1     1     2     1     2  1  2  1     1           1  1     1         |             
      Toxic Hepatopathy                    |                                                                          |             
      Bile Duct, Cyst                      |    3                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 2| 2| 7| 5| 7| 7| 7| 6| 7| 4| 4| 7| 6| 7| 7| 5| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 8| 3| 1| 4| 3| 6| 2| 2| 2| 0| 3| 9| 2| 2| 7| 2| 2| 8| 9| 3| 2| 1| 8|             
                                           | 9| 8| 4| 0| 9| 6| 0| 1| 8| 8| 8| 5| 0| 7| 0| 9| 5| 8| 9| 6| 3| 0| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Degeneration          |                                                                          |             
      Hepatocyte, Hypertrophy              |       1                    1  1                 1           1        1  1|             
      Hepatocyte, Multinucleated           | 1                                                     1                  |             
      Oval Cell, Hyperplasia               |       1                                                                  |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |       1     1        1  2     1  1              1  1  1              1   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                          2               |             
      Hyperplasia, Squamous                |             2                 1     1                    2               |             
      Ulcer                                |             2                                                            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +  +              +  +  +  +  +  +     +  +  +  +  +              +  +|             
      Peridontal Tissue, Inflammation      |    1  1              1  2  1  1  1  1     1  1  1  1  1              2  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1        1  1     1        1  1        1           1     1         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 2| 2| 7| 5| 7| 7| 7| 6| 7| 4| 4| 7| 6| 7| 7| 5| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 8| 3| 1| 4| 3| 6| 2| 2| 2| 0| 3| 9| 2| 2| 7| 2| 2| 8| 9| 3| 2| 1| 8|             
                                           | 9| 8| 4| 0| 9| 6| 0| 1| 8| 8| 8| 5| 0| 7| 0| 9| 5| 8| 9| 6| 3| 0| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1     1        2     1  2  1  2  2     1  1     2  1     2  1     1  1|             
      Degeneration, Cystic                 | 2     3                             3           3     2                 3|             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hyperplasia                          |                         2  2              2  2  2                        |             
      Hypertrophy                          | 3  2  3  1        2  2  2  2  1  1  3  1  1  2  3  3  3        2  1  2  3|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |       2     2           2                 1                             2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  1                 1              3        2        3        2  3     2|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Hyperplasia                          |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            2  3  3  3     3        3  1  3           2  2|             
      Vacuolization Cytoplasmic            |                                                 1                        |             
      Pars Distalis, Hyperplasia           | 1  2              2  2                       3  3              3         |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      C-Cell, Hyperplasia                  | 2                 2           3                    2                 2   |             
      Follicular Cell, Hypertrophy         | 1     2           1     1           1  1     1  1  1  1        1     1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |          2                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 2| 2| 7| 5| 7| 7| 7| 6| 7| 4| 4| 7| 6| 7| 7| 5| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 8| 3| 1| 4| 3| 6| 2| 2| 2| 0| 3| 9| 2| 2| 7| 2| 2| 8| 9| 3| 2| 1| 8|             
                                           | 9| 8| 4| 0| 9| 6| 0| 1| 8| 8| 8| 5| 0| 7| 0| 9| 5| 8| 9| 6| 3| 0| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation                         | 2  1  2  2  2  1  1  2  2  2  2     2  2  1  2  2  1  2  1  2  3  1  3  1|             
      Duct, Cyst                           |    3  2  3  2  3     3  3  2           3  3     1  3  3        2  3  3  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  4  4           4  4  4  4  4  4  4  4  4  4  4  4     4  4  4  4  4|             
      Cyst                                 |                      2                    2  2  2  2     2  2     2     2|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          2           3                 2                                 |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |    3  1  3           4  2                    1     2  2  1  1     1  1  2|             
      Endometrium, Hyperplasia, Cystic     |    1     1              3  2  3     2  4     3  2  1  3  2  2  2     2  3|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |       3     4  3        3  2  3     2  3     3  3  2     3  4     3  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                      +                                                   |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Hemorrhage              |                      2                                                   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2                                       |             
      Ectasia                              |          2                                                               |             
      Hyperplasia, Plasma Cell             | 2     2  3  2     2  2     2  2  2  2        2  2  2  3     2  2  2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                      X                                                   |             
      Hematopoietic Cell Proliferation     | 2     3  2  3  3  2  3  2  2  2  1  2  3  1  3  2  2  2  1  3  2  2  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 2| 2| 7| 5| 7| 7| 7| 6| 7| 4| 4| 7| 6| 7| 7| 5| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 8| 3| 1| 4| 3| 6| 2| 2| 2| 0| 3| 9| 2| 2| 7| 2| 2| 8| 9| 3| 2| 1| 8|             
                                           | 9| 8| 4| 0| 9| 6| 0| 1| 8| 8| 8| 5| 0| 7| 0| 9| 5| 8| 9| 6| 3| 0| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Infarct                              |          2                                                               |             
      Pigmentation                         | 2  2     2  1  2  2  2  2  2  2  3  2     3  1  2  2  2  3  1  2  2  2  2|             
      Lymphatic, Angiectasis               |          2                                                               |             
      Lymphoid Follicle, Atrophy           |       2                          2        2              2               |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  2  2     3  4  2  3     2     2  4  2     4  3  3  3  4     2  4     2|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2           1  1  1        2  1           1     1  1     2              1|             
      Inflammation, Granulomatous          |                            2                    2                        |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  1  2  2  1     2  2  1  1  2  2  2  2  1  2  1     1        2     1  2|             
      Inflammation                         | 1  2  1              2     1                 1                           |             
      Alveolar Epithelium, Hyperplasia     | 1        1        1           1     1                                   2|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |                                                       1                  |             
      Alveolus, Metaplasia, Squamous       |                               1                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1     1                             1               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 2| 2| 7| 5| 7| 7| 7| 6| 7| 4| 4| 7| 6| 7| 7| 5| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 8| 3| 1| 4| 3| 6| 2| 2| 2| 0| 3| 9| 2| 2| 7| 2| 2| 8| 9| 3| 2| 1| 8|             
                                           | 9| 8| 4| 0| 9| 6| 0| 1| 8| 8| 8| 5| 0| 7| 0| 9| 5| 8| 9| 6| 3| 0| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                            2                                             |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Septum, Inflammation                 |                      1                                                   |             
      Squamous Epithelium, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              1  1  1           1  1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                              X        X                  |             
      Inflammation, Suppurative            |                                                                         1|             
      Mineralization                       |    1  1  1  1  1  1  1     1           1  1  1  1  1  1  2  1  1  1  1   |             
      Nephropathy                          | 1  1  1  1  2     2  1  2  1  1     1     1  1     1  1  1     1  2     1|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Hyperplasia            |                   1                                                      |             
      Transitional Epithelium, Hyperplasia |                                                                         1|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                         2|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 3| 6| 3| 7| 4| 1| 5| 6| 2| 1| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 2| 0| 1| 3| 3| 3| 2| 3| 7| 0| 7| 0| 2| 5| 1| 8| 3| 9| 9| 2| 6| 3| 8|             
                                           | 8| 0| 9| 1| 7| 0| 0| 0| 8| 6| 5| 1| 7| 0| 8| 1| 6| 7| 8| 7| 6| 9| 8| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 0| 1| 2| 3| 4| 6| 7| 2| 5| 6| 7| 8| 9| 0| 6| 7| 9| 1| 3| 5| 7| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                  X     X                                 |             
      Muscularis, Inflammation             |                                                                          |             
      Periesophageal Tissue, Inflammation  |                                  3     3                                 |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1                                                                     |             
      Basophilic Focus                     |    X  X        X        X                 X  X        X              X   |             
      Basophilic Focus, Multiple           |                   X  X        X     X                                    |             
      Clear Cell Focus                     | X                                                                        |             
      Clear Cell Focus, Multiple           |    X                                      X                              |             
      Eosinophilic Focus                   | X  X  X                                            X              X      |             
      Eosinophilic Focus, Multiple         |          X                    X                                          |             
      Fatty Change, Diffuse                |             1                    2     2           1                     |             
      Fatty Change, Focal                  |    1           1  1                       1                              |             
      Hematopoietic Cell Proliferation     | 1        1              1     1  1           2     1  2  1  1     1     1|             
      Hepatodiaphragmatic Nodule           |                                        X           X        X            |             
      Inflammation                         | 1  1  1  1     1  1  1  1  2  1  1  1     1  1  1     1  1     2  1  1  1|             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           |    X           X  X  X  X                 X                          X  X|             
      Necrosis                             |                                                                          |             
      Pigmentation                         |          1              1  1        2        1                 2     1   |             
      Toxic Hepatopathy                    |                         1           1                                1   |             
      Bile Duct, Cyst                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 3| 6| 3| 7| 4| 1| 5| 6| 2| 1| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 2| 0| 1| 3| 3| 3| 2| 3| 7| 0| 7| 0| 2| 5| 1| 8| 3| 9| 9| 2| 6| 3| 8|             
                                           | 8| 0| 9| 1| 7| 0| 0| 0| 8| 6| 5| 1| 7| 0| 8| 1| 6| 7| 8| 7| 6| 9| 8| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 0| 1| 2| 3| 4| 6| 7| 2| 5| 6| 7| 8| 9| 0| 6| 7| 9| 1| 3| 5| 7| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                1                                                         |             
      Bile Duct, Hyperplasia               |                      1                    1                              |             
      Centrilobular, Degeneration          |                                              2        2                  |             
      Hepatocyte, Hypertrophy              | 1        1     1  1     1                    1        1        1        1|             
      Hepatocyte, Multinucleated           |                                     1                                    |             
      Oval Cell, Hyperplasia               |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Necrosis                             |                         3                                                |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |                            1           2  1        1                 2   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    1                     |             
      Acinus, Atrophy                      |                                                    1                     |             
      Artery, Inflammation, Chronic Active |                      1                                                   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                   1                                                      |             
      Ulcer                                |                   1                                                      |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                1                                                         |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                            +           +           +                 +  +|             
      Peridontal Tissue, Inflammation      |                            1           1           1                 2  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1              1  1  1           1     1  1     1                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 3| 6| 3| 7| 4| 1| 5| 6| 2| 1| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 2| 0| 1| 3| 3| 3| 2| 3| 7| 0| 7| 0| 2| 5| 1| 8| 3| 9| 9| 2| 6| 3| 8|             
                                           | 8| 0| 9| 1| 7| 0| 0| 0| 8| 6| 5| 1| 7| 0| 8| 1| 6| 7| 8| 7| 6| 9| 8| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 0| 1| 2| 3| 4| 6| 7| 2| 5| 6| 7| 8| 9| 0| 6| 7| 9| 1| 3| 5| 7| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Inflammation                         |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2           2  2  2        1     1        1     1           2     2  1|             
      Degeneration, Cystic                 | 3        2        2     1  2  2           2                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2                 2                                3  2              2   |             
      Hypertrophy                          | 3  2  3  3     1  3  1  2  3  3     2     2        1  3  2     1  1  3  2|             
      Necrosis                             |                            2     2                                       |             
      Vacuolization Cytoplasmic            |    1     2                 2                       2  1  1           1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                       2                 1                    1      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  M  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3        3  3     2     2  2  3                          3  1      |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           | 3        2                       3        2           3                 1|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                  3                                       |             
      C-Cell, Hyperplasia                  |                                                    3                 2   |             
      Follicular Cell, Hypertrophy         |          1              2     2  1  2     1                 2     1     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 3| 6| 3| 7| 4| 1| 5| 6| 2| 1| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 2| 0| 1| 3| 3| 3| 2| 3| 7| 0| 7| 0| 2| 5| 1| 8| 3| 9| 9| 2| 6| 3| 8|             
                                           | 8| 0| 9| 1| 7| 0| 0| 0| 8| 6| 5| 1| 7| 0| 8| 1| 6| 7| 8| 7| 6| 9| 8| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 0| 1| 2| 3| 4| 6| 7| 2| 5| 6| 7| 8| 9| 0| 6| 7| 9| 1| 3| 5| 7| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation                         | 1     2  2  2  1  2  2  2     2  1  1     2  2     2        1  2  1  3  2|             
      Duct, Cyst                           |       3  3  2     3  2     3  2  3  4  3     4              3  2     1   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     4  4     4  4     4  4  4  4  4  4     4                 4  4  4  4|             
      Cyst                                 |       2           2     2  2        2        2     2           3  2      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |          2              1        1     2     1                    2  1   |             
      Endometrium, Hyperplasia, Cystic     | 3     1  1              1     3     2  2     1                 1  3  3  3|             
                                           |__________________________________________________________________________|             
   Vagina                                  |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                2  2                                                      |             
      Hyperplasia                          | 2     3  3  3           2  3  3  3  4  3     4  3  3  4  4  4     4  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                            +                          +     +            |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                       3                  |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                             2            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                                  2                                       |             
      Hyperplasia, Plasma Cell             | 2  3     2     2  2  2  2  2  2  2  2        2        2  2  2  2     2  3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2     3  1  1  1  2  2     3  2  2     2  3     3  4  4  3  2  4  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 3| 6| 3| 7| 4| 1| 5| 6| 2| 1| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 2| 0| 1| 3| 3| 3| 2| 3| 7| 0| 7| 0| 2| 5| 1| 8| 3| 9| 9| 2| 6| 3| 8|             
                                           | 8| 0| 9| 1| 7| 0| 0| 0| 8| 6| 5| 1| 7| 0| 8| 1| 6| 7| 8| 7| 6| 9| 8| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 0| 1| 2| 3| 4| 6| 7| 2| 5| 6| 7| 8| 9| 0| 6| 7| 9| 1| 3| 5| 7| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Infarct                              |                                                                          |             
      Pigmentation                         | 2  2  2  1  2  3  2  2  2     1  2  3  2  2  1  3  1  1  1  1  2  1  2  2|             
      Lymphatic, Angiectasis               |                                                                          |             
      Lymphoid Follicle, Atrophy           |             3              3                                             |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              | 2        3  4     2  2  3  4  4  2     2     2           2     2     2  2|             
      Hemorrhage                           |                                                 2                        |             
      Hyperplasia, Lymphoid                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2           1     2  1     2     1     2        2  2  1     1  1      |             
      Inflammation, Granulomatous          | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2     2  2     2  2     1  2  1     2  2  1  1        2        2  2  2  2|             
      Inflammation                         |                                           1                              |             
      Alveolar Epithelium, Hyperplasia     | 1        1     2  1     1  1                                             |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |                                                                1     1   |             
      Alveolus, Metaplasia, Squamous       |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1           1           1                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 6| 3| 6| 3| 7| 4| 1| 5| 6| 2| 1| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 3| 2| 0| 1| 3| 3| 3| 2| 3| 7| 0| 7| 0| 2| 5| 1| 8| 3| 9| 9| 2| 6| 3| 8|             
                                           | 8| 0| 9| 1| 7| 0| 0| 0| 8| 6| 5| 1| 7| 0| 8| 1| 6| 7| 8| 7| 6| 9| 8| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    20 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 0| 1| 2| 3| 4| 6| 7| 2| 5| 6| 7| 8| 9| 0| 6| 7| 9| 1| 3| 5| 7| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                               1                                      2   |             
      Septum, Inflammation                 |             1           1                                                |             
      Squamous Epithelium, Hyperplasia     | 1                                                                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation    |                                  3     3                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1        1                    1                       1  1               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                X                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  2  1  1  1     1  1     1  1  1     1  1     1|             
      Nephropathy                          |    1     1     1  1  1  1        1  2     1  1     1           2     2  1|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    20 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
      Perforation                          |                                                                          |      2     |
      Muscularis, Inflammation             |                                                                          |      1  1.0|
      Periesophageal Tissue, Inflammation  |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      5     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      4  1.8|
      Basophilic Focus                     |                                                                          |      9     |
      Basophilic Focus, Multiple           |                                                                          |     11     |
      Clear Cell Focus                     |                                                                          |      7     |
      Clear Cell Focus, Multiple           |                                                                          |      3     |
      Eosinophilic Focus                   | X                                                                        |      9     |
      Eosinophilic Focus, Multiple         |       X                                                                  |      9     |
      Fatty Change, Diffuse                | 1  2                                                                     |     10  1.4|
      Fatty Change, Focal                  |                                                                          |      5  1.0|
      Hematopoietic Cell Proliferation     |    1  1                                                                  |     27  1.1|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Inflammation                         | 1  1  1                                                                  |     47  1.1|
      Mixed Cell Focus                     |                                                                          |      1     |
      Mixed Cell Focus, Multiple           | X                                                                        |     23     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    20 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Necrosis                             |    3                                                                     |      3  2.0|
      Pigmentation                         |    2                                                                     |     21  1.3|
      Toxic Hepatopathy                    |                                                                          |      3  1.0|
      Bile Duct, Cyst                      |       3                                                                  |      2  3.0|
      Bile Duct, Fibrosis                  |       1                                                                  |      2  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      2  1.0|
      Centrilobular, Degeneration          |    3                                                                     |      3  2.3|
      Hepatocyte, Hypertrophy              |    1                                                                     |     17  1.0|
      Hepatocyte, Multinucleated           |    1                                                                     |      4  1.0|
      Oval Cell, Hyperplasia               |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Necrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  52        |
      Gingival, Hyperplasia, Squamous      |       4                                                                  |     16  1.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      5  1.4|
      Ulcer                                |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |    2                                                                     |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +  +                                                                  |  22        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    20 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Peridontal Tissue, Inflammation      |    1  1                                                                  |     22  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Cardiomyopathy                       |    2  1                                                                  |     19  1.1|
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 1     1                                                                  |     30  1.4|
      Degeneration, Cystic                 |    2                                                                     |     14  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |     10  2.1|
      Hypertrophy                          | 1  2  3                                                                  |     43  2.1|
      Necrosis                             |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            | 1     2                                                                  |     14  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |       2                                                                  |     14  1.9|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  44        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |       2                                                                  |     20  2.5|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |    2                                                                     |     14  2.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    20 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      Inflammation                         |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |    3  2                                                                  |      9  2.3|
      Follicular Cell, Hypertrophy         |    1  1                                                                  |     24  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation                         | 2  2  1                                                                  |     46  1.7|
      Duct, Cyst                           | 3  2  3                                                                  |     34  2.6|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              |    4  4                                                                  |     38  4.0|
      Cyst                                 | 2  2                                                                     |     20  2.1|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      3  2.3|
      Inflammation, Suppurative            |       1                                                                  |      1  1.0|
      Metaplasia, Squamous                 |       3                                                                  |     21  1.8|
      Endometrium, Hyperplasia, Cystic     |    1                                                                     |     29  2.1|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      2  2.0|
      Hyperplasia                          |    3  4                                                                  |     37  3.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    20 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Congestion                           |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             | 2                                                                        |     38  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Accessory Spleen                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 2  3  2                                                                  |     48  2.3|
      Infarct                              |                                                                          |      1  2.0|
      Pigmentation                         | 2  2  1                                                                  |     50  1.9|
      Lymphatic, Angiectasis               |                                                                          |      1  2.0|
      Lymphoid Follicle, Atrophy           |    2                                                                     |      7  2.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +                                                                  |  50        |
      Atrophy                              |    4  2                                                                  |     36  2.7|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Hyperplasia                          | 2     2                                                                  |     26  1.5|
      Inflammation, Granulomatous          |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    20 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 1  2  2                                                                  |     40  1.7|
      Inflammation                         |                                                                          |      7  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |     12  1.2|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 2  1                                                                     |      5  1.2|
      Alveolus, Metaplasia, Squamous       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |    1  2                                                                  |      8  1.1|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  1.5|
      Septum, Inflammation                 |                                                                          |      3  1.0|
      Squamous Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
      Peritracheal Tissue, Inflammation    |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
      Retina, Atrophy                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     10  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 3| 7| 2|                                                                 |            |
                                           | 0| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    20 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |       X                                                                  |      4     |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       | 1  1                                                                     |     42  1.0|
      Nephropathy                          | 1     1                                                                  |     35  1.2|
      Renal Tubule, Dilatation             |    2                                                                     |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              3     3                     |             
      Perforation                          |                                                                          |             
      Muscularis, Inflammation             |                                                                          |             
      Periesophageal Tissue, Inflammation  |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |          X                 X              X                              |             
      Basophilic Focus, Multiple           |                               X                                          |             
      Cholangiofibrosis                    |                                  1                                       |             
      Clear Cell Focus                     |                      X                                                   |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |                                  X     X  X                    X         |             
      Eosinophilic Focus, Multiple         |                X           X                          X                  |             
      Fatty Change, Diffuse                | 1           1           1              2              1  1  1            |             
      Fatty Change, Focal                  |    1              1                                                      |             
      Hematopoietic Cell Proliferation     |       1           1        1        1     1           1  2     1        1|             
      Hepatodiaphragmatic Nodule           |             X                                                            |             
      Hyperplasia, Nodular                 |    X                                                                    X|             
      Inflammation                         | 1  1  1  1  1  1  2  1  1  1  1  2  1  2  1  2  1  1  2  1  2  1  1  1  2|             
      Mixed Cell Focus                     |                                           X                              |             
      Mixed Cell Focus, Multiple           | X  X     X           X        X        X                 X     X  X     X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 1  2  2  2  2  2        2  1  2  2  2  2  2  1  2        1  1  1  2  1  1|             
      Toxic Hepatopathy                    |                            1           1                                 |             
      Bile Duct, Cyst                      |                                        2                                 |             
      Bile Duct, Fibrosis                  |                                        1                                 |             
      Bile Duct, Hyperplasia               |                      1                                                   |             
      Centrilobular, Degeneration          |             1              2                                1            |             
      Hepatocyte, Hypertrophy              |       1     1  1           1     1                          1  1     1   |             
      Hepatocyte, Multinucleated           |    1     1  1           1  1  1        1              1              1  1|             
      Oval Cell, Hyperplasia               |       1     1                                                            |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Cyst                       |                                                                3         |             
      Gingival, Hyperplasia                |                                                                          |             
      Gingival, Hyperplasia, Squamous      | 1        2        2        1     1     1        1           1        1   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      1   |             
      Lipomatosis                          |                                                       2                  |             
      Acinus, Atrophy                      |                                                                      2   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                2                 2              3     2                  |             
      Inflammation                         |                                  3              2                        |             
      Mineralization                       |    2                                                                     |             
      Ulcer                                |                                  2              2                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                 3                        |             
      Hyperplasia                          |                               2                                          |             
      Inflammation                         |                               2                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Mineralization                       |       1                                            2                     |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +        +        +     +  +  +  +  +  +  +     +           +     +      |             
      Peridontal Tissue, Inflammation      | 1        1        3     2  2  1  1  3  1  3     3           1     3      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1           1     1        1                                1         |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1        2  2  1     1        1  1     2  1  1           1     2  1  1  1|             
      Atrophy                              |    4                                                                     |             
      Degeneration, Cystic                 | 1        2                 2  1                       3  2  3  2  2      |             
      Hemorrhage                           |                                                       3                  |             
      Hyperplasia                          |                                  2           3                 3         |             
      Hypertrophy                          | 3  1     4     1  2  2  1  2  3  1  1  3  2  1        4  3  3     2  1  1|             
      Vacuolization Cytoplasmic            |                                              2  2     3           1     1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1     3           1  2                                2  3|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2           2  3                                               2        3|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                      3     2  3  4     2                 3        2      |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    3                       1     2     1                 3     1  2     3|             
      Follicle, Cyst                       |                                           2                              |             
      Follicular Cell, Hypertrophy         |    1           1     1  1  1           1                       1        1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1  2  1  3  1  3  1  1  1  2  3  2  2  2  2  2  1  2  1  2  1  3  3|             
      Duct, Cyst                           | 3     2  3  2  2        2  3  2  2  2  3  1  3  2  2  3  3  3  3     3   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4  4  4  4        4  4  4  4  4  4  4  4  4  4  4  4  4  4        4|             
      Cyst                                 | 2  2                             2     2                          2  3   |             
      Fibrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |             2  1                    2                                    |             
      Metaplasia, Squamous                 | 1     4  2  4  1        1  1     1     2  1  1  2  1           3  2      |             
      Ulcer                                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 1        2     3        2  2  3  2  4        1     1     1     1  2     3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  4           4        3        4     2  3  4  2  2  4  3  2         |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                             +            |             
      Lumbar, Hyperplasia, Histiocytic     |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                2                                                         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2  2  2  2     2     2        2  2     2  2           2  2  2  2  2     2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  1  3  2  1  1  3  2  1  2  2  1  3  2  2  1  3  1  3  3     2  1  1  2|             
      Pigmentation                         | 2  1     2  3  2  1  2  2  1  2  3  1  2  2  2  1  3  2  1  1  2  2  2  2|             
      Lymphoid Follicle, Atrophy           |                                                 3  3  3                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              | 2  2  3  3  4  2  3  2  3  2  2  4  2  2  2  3  4  4           3  3  3  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3                 2              2                       2|             
      Hyperplasia                          |    2           3  2  2     1                          2        2         |             
      Inflammation, Granulomatous          |                2                 2              2                        |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |          +              +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  2                                       |             
      Gliosis                              |                                  2                                       |             
      Hydrocephalus                        |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Peripheral Nerve                        |                                                             +            |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
      Hemorrhage                           |                                                             3            |             
      Necrosis                             |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2     2  2  1     1  2  1  2  2     2  1  2  1     2     2  2  2  2  2|             
      Inflammation                         |                         2           1        2                           |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                    2                     |             
      Alveolar Epithelium, Hyperplasia     | 1        1  1  2     1           1        1                    1         |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |    1                          3        1                          1     2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1  2                          1     2  1  1     1        1            |             
      Respiratory Epithelium, Hyperplasia  |                                                             2            |             
      Septum, Inflammation                 |                                           1                              |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  2     1     1                 1                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                X                                                         |             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |                                     1                                   1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 6| 6| 5| 7| 5| 6| 7| 5| 4| 7| 7| 4| 4| 3| 5| 7| 5| 7| 7| 4| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 1| 4| 2| 2| 7| 6| 2| 7| 7| 2| 2| 7| 2| 0| 6| 3| 8| 2| 2| 9| 2|             
                                           | 9| 5| 5| 9| 6| 5| 5| 9| 0| 8| 8| 0| 0| 8| 8| 0| 9| 2| 1| 0| 9| 9| 8| 9| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 5| 1| 2| 4| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1     1  1  1     1  2  2     1  1  2  1  1  1|             
      Nephropathy                          | 1  1     2  1  1  1  2  1  1  1  1     3  2  1     1  3        1  1  1  1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Transitional Epithelium, Hyperplasia |                               1           1                              |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Perforation                          |       4                                                                  |             
      Muscularis, Inflammation             |                                                                          |             
      Periesophageal Tissue, Inflammation  |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                                   |             
      Artery, Inflammation, Chronic Active |                                                          3               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      2   |             
      Basophilic Focus                     | X  X     X     X                                X     X     X            |             
      Basophilic Focus, Multiple           |                                  X     X                 X               |             
      Cholangiofibrosis                    |                                  2                       1               |             
      Clear Cell Focus                     |                                                             X            |             
      Clear Cell Focus, Multiple           |                         X                                                |             
      Eosinophilic Focus                   |          X     X                                               X     X   |             
      Eosinophilic Focus, Multiple         | X                             X  X     X        X                 X      |             
      Fatty Change, Diffuse                |       1  1     1                          1           1                  |             
      Fatty Change, Focal                  |             2           2        1                                       |             
      Hematopoietic Cell Proliferation     | 1  1           1                 1  1     1  1  1     1  1  1  1        1|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation                         | 1  1  1  1  1  1  1  1  1  2  1  1  1     1  1  1        1  1  1  1  1  1|             
      Mixed Cell Focus                     |    X                                                                     |             
      Mixed Cell Focus, Multiple           | X        X  X  X  X     X        X  X     X           X  X  X  X  X     X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Necrosis                             |                      3                       3                           |             
      Pigmentation                         | 1        2     1  2  1  1  2     1  1  1  2  1  1     1  2  2  2  1  1  1|             
      Toxic Hepatopathy                    |                            1     2              1        1     1         |             
      Bile Duct, Cyst                      |                                     3                          1         |             
      Bile Duct, Fibrosis                  |                                                          2               |             
      Bile Duct, Hyperplasia               |             1                                                            |             
      Centrilobular, Degeneration          |                                              2                           |             
      Hepatocyte, Hypertrophy              |                            1  1  1     1     1  1     1        1  1      |             
      Hepatocyte, Multinucleated           |                                           1  1                           |             
      Oval Cell, Hyperplasia               |                1                                         1     1         |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                         +                                +               |             
      Artery, Inflammation, Chronic Active |                         3                                4               |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Cyst                       |                                                                          |             
      Gingival, Hyperplasia                |             1                                                            |             
      Gingival, Hyperplasia, Squamous      |    1           1     2  1        1     1                 1  1     2      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Lipomatosis                          |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Inflammation, Chronic Active |                         2                                3               |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                3                 3                                       |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                      1                                                   |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Mineralization                       |                                                                   1      |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +        +        +  +  +  +  +     +           +     +  +  +  +  +  +|             
      Peridontal Tissue, Inflammation      | 1  1        1        2  1  2  1  1     1           1     1  1  3  2  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                         1        1     1                 1     1  1     1|             
      Inflammation                         |       2                                                                  |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     1  1  2     1     1        1  1  2  2     1     1     2     2  1  2|             
      Atrophy                              |                                                                          |             
      Degeneration, Cystic                 |          2     2           2           2  2  2              3  3  3      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 2              2                       2                                 |             
      Hypertrophy                          | 2  2  1  3  1  3  2  2  2  3  2  2  2  3  3     1     2  2  3  3  3  2  2|             
      Vacuolization Cytoplasmic            |                2                                                         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                 1     2           2     2                    2         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3           3        3     2     1                 2  3   |             
      Cyst                                 |                               2                                          |             
      Pars Distalis, Hyperplasia           |       2  2        2                                            2         |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                           2                 3  2     1   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hypertrophy         | 1  1  2  2  1  1                 1  2           1     1  2  1  1     1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  2  1  1  1  2  1  1  2     2  2  4  1  1  1  1  2  2  1  2  2  1     2|             
      Duct, Cyst                           |    2  2  2  1  1     2  2  3  1  2  4  2  3  3     3        2  3     3  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4     4  4     4  4     4  4  4  4  4     4  4  4  4  4  4  4|             
      Cyst                                 |    2     2     3  2           2  4  2  2                    3  2     2   |             
      Fibrosis                             |                                                             3            |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Chronic Active         |                               3                          4     3         |             
      Inflammation, Suppurative            |       1                          1        1                             2|             
      Metaplasia, Squamous                 | 1  1  3  2  1  1     1     2  3     1  2  3  2  1     1  3     3  2  2   |             
      Ulcer                                |                                                          3               |             
      Endometrium, Hyperplasia, Cystic     | 2  3     3  2  2  3              2  3  2        2     2  2  2  4  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  4  2  2     2  2  3        3  4  3  3  3  4  1  3  3  4     3  2      |             
      Hyperplasia, Reticulum Cell          |                                                                3         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                       +              +                           |             
      Lumbar, Hyperplasia, Histiocytic     |                                              2                           |             
      Lumbar, Hyperplasia, Plasma Cell     |                               3                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|       3                                                                  |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                3                                                         |             
      Hyperplasia, Plasma Cell             | 2        2        2        3     3  2  2  3           2  2  2  2  2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  3  2  1  3  2  1  2  2  1  2  3  2  1  1  3  2     3  3  2  2  2  2  2|             
      Pigmentation                         | 2  1  3  2  2  2  2  1  2  3  2  2  2     2     1     1  1  2     1  2  2|             
      Lymphoid Follicle, Atrophy           |                                        2                             2   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4  4     2  2  3     4  3  4  3  3  3  3     2  2  2  2  4  3     2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   2                                                      |             
      Hyperplasia                          | 1              1  1  1  2  2     2                          1  1  2  1   |             
      Inflammation, Granulomatous          |                                                             2            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Gliosis                              |                                                                          |             
      Hydrocephalus                        |                            2                                             |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  1        2  1  2        2  2     2     1  1  2     1  2  1  2  2  2  2|             
      Inflammation                         |       2        1                                      1                  |             
      Metaplasia, Squamous                 |                                                                         1|             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             1     1                 2     1     1        1  1  1  1  1  2|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1           1                                            1     1         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         1                                   1  1         |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Septum, Inflammation                 |                         1                                                |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation    |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1  1     1     1  1  1                                1  1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Cyst                                 |                               2                                          |             
      Inflammation, Suppurative            |                   1                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 7| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 3| 2| 2| 3| 1| 4| 7| 4| 3| 3| 7| 3| 9| 0| 8| 1| 2| 2| 3| 2| 3| 3|             
                                           | 8| 5| 2| 0| 4| 8| 0| 0| 8| 0| 5| 0| 0| 5| 0| 9| 3| 9| 6| 9| 8| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    44 NG/KG                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8| 9| 0| 6| 7| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Mineralization                       |    1     1  1  1  1     1  1  1     1  1  1  1        1  1  1  1  1  1   |             
      Nephropathy                          | 2  1  1  2  1  3  1     2  1  1  2  1     1              2  1  2  1  1  1|             
      Artery, Inflammation, Chronic Active |                         3                                                |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         1                                                |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    44 NG/KG                               | 8| 9| 9|                                                                 |      L     |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      2  3.0|
      Perforation                          |                                                                          |      1  4.0|
      Muscularis, Inflammation             | 1                                                                        |      1  1.0|
      Periesophageal Tissue, Inflammation  |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |     10     |
      Basophilic Focus, Multiple           | X     X                                                                  |      6     |
      Cholangiofibrosis                    |                                                                          |      3  1.3|
      Clear Cell Focus                     |                                                                          |      2     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Eosinophilic Focus                   | X                                                                        |      9     |
      Eosinophilic Focus, Multiple         |                                                                          |      9     |
      Fatty Change, Diffuse                |                                                                          |     12  1.1|
      Fatty Change, Focal                  |       1                                                                  |      6  1.3|
      Hematopoietic Cell Proliferation     | 1  1                                                                     |     24  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    44 NG/KG                               | 8| 9| 9|                                                                 |      L     |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hyperplasia, Nodular                 |    X                                                                     |      3     |
      Inflammation                         | 1  2  1                                                                  |     50  1.2|
      Mixed Cell Focus                     |                                                                          |      2     |
      Mixed Cell Focus, Multiple           | X  X                                                                     |     27     |
      Necrosis                             |       1                                                                  |      3  2.3|
      Pigmentation                         | 1  2  1                                                                  |     44  1.5|
      Toxic Hepatopathy                    |    1                                                                     |      8  1.1|
      Bile Duct, Cyst                      |                                                                          |      3  2.0|
      Bile Duct, Fibrosis                  |                                                                          |      2  1.5|
      Bile Duct, Hyperplasia               |                                                                          |      2  1.0|
      Centrilobular, Degeneration          |                                                                          |      4  1.5|
      Hepatocyte, Hypertrophy              |                                                                          |     17  1.0|
      Hepatocyte, Multinucleated           |       1                                                                  |     13  1.0|
      Oval Cell, Hyperplasia               |    2                                                                     |      6  1.2|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   3        |
      Artery, Inflammation, Chronic Active |                                                                          |      2  3.5|
      Fat, Necrosis                        |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Cyst                       |                                                                          |      1  3.0|
      Gingival, Hyperplasia                |                                                                          |      1  1.0|
      Gingival, Hyperplasia, Squamous      |    1                                                                     |     19  1.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Lipomatosis                          |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      6  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    44 NG/KG                               | 8| 9| 9|                                                                 |      L     |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |  30        |
      Peridontal Tissue, Inflammation      |    1                                                                     |     30  1.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |    1                                                                     |     13  1.0|
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  52        |
      Angiectasis                          | 3     1                                                                  |     33  1.4|
      Atrophy                              |                                                                          |      1  4.0|
      Degeneration, Cystic                 |                                                                          |     18  2.2|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          | 2                                                                        |      7  2.3|
      Hypertrophy                          | 2  2  1                                                                  |     46  2.1|
      Vacuolization Cytoplasmic            |    2                                                                     |      7  1.9|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    44 NG/KG                               | 8| 9| 9|                                                                 |      L     |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Hyperplasia                          | 1  2                                                                     |     14  1.9|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |    2                                                                     |     13  2.4|
      Cyst                                 |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     11  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  | 1                                                                        |     13  1.9|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hypertrophy         | 1  1                                                                     |     24  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 2  2  2                                                                  |     51  1.7|
      Duct, Cyst                           | 2     3                                                                  |     41  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
      Atrophy                              | 4  4  4                                                                  |     43  4.0|
      Cyst                                 |                                                                          |     17  2.3|
      Fibrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Adenomyosis                          | 2                                                                        |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    44 NG/KG                               | 8| 9| 9|                                                                 |      L     |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      7  1.4|
      Metaplasia, Squamous                 |    1  2                                                                  |     36  1.8|
      Ulcer                                |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2  1                                                                     |     33  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 2  3  2                                                                  |     35  2.9|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
      Lumbar, Hyperplasia, Histiocytic     |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             | 2  2                                                                     |     31  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Atrophy                              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Hematopoietic Cell Proliferation     | 2  2  1                                                                  |     51  1.9|
      Pigmentation                         | 2  2  2                                                                  |     48  1.8|
      Lymphoid Follicle, Atrophy           |       3                                                                  |      6  2.7|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  52        |
      Atrophy                              | 2  3  3                                                                  |     44  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    44 NG/KG                               | 8| 9| 9|                                                                 |      L     |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      5  2.2|
      Hyperplasia                          | 1  1                                                                     |     20  1.6|
      Inflammation, Granulomatous          |                                                                          |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  2.0|
      Gliosis                              |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 1     1                                                                  |     40  1.7|
      Inflammation                         |                                                                          |      6  1.5|
      Metaplasia, Squamous                 | 1                                                                        |      2  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |     20  1.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 7|                                                                 |            |
                                           | 8| 8| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    44 NG/KG                               | 8| 9| 9|                                                                 |      L     |
                                           | 8| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |                                                                          |      9  1.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     11  1.2|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Septum, Inflammation                 |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
      Peritracheal Tissue, Inflammation    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     13  1.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  52        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      3  1.0|
      Mineralization                       | 1  1  1                                                                  |     43  1.1|
      Nephropathy                          | 2  1  1                                                                  |     42  1.4|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                          2               |             
      Periesophageal Tissue, Inflammation  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
      Inflammation                         |                2                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Artery, Mineralization               |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                 X  X           X     X                    X           X|             
      Basophilic Focus, Multiple           |                                              X                           |             
      Cholangiofibrosis                    |                                                                         2|             
      Clear Cell Focus, Multiple           | X        X           X  X                                            X   |             
      Eosinophilic Focus                   |          X     X                 X           X  X        X               |             
      Eosinophilic Focus, Multiple         |    X  X           X        X           X              X     X            |             
      Fatty Change, Diffuse                | 1        2  1        1  1        1  1                       1        1   |             
      Fatty Change, Focal                  |                      3     1  1                                          |             
      Hematopoietic Cell Proliferation     |    1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1              1  1|             
      Hepatodiaphragmatic Nodule           |                                                                         X|             
      Hyperplasia, Nodular                 |          X              X                                                |             
      Inflammation                         | 1  2  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  2     2  1  1|             
      Mixed Cell Focus                     |                                              X              X            |             
      Mixed Cell Focus, Multiple           | X  X     X  X        X  X     X  X  X              X                 X  X|             
      Necrosis                             |          2                                                        3      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         | 2        2  2  2  1  2  1  1  2  2  2  2  1        2  2     2     2  2  1|             
      Toxic Hepatopathy                    | 1        2  2        1  1  1                 1                    1  1  1|             
      Bile Duct, Cyst                      |                                                    2                     |             
      Bile Duct, Fibrosis                  |                                        1                                 |             
      Bile Duct, Hyperplasia               |                            1                                             |             
      Centrilobular, Degeneration          |                                                                          |             
      Hepatocyte, Hypertrophy              |    1  1        1  1     1                 1  1     1     1           1  1|             
      Hepatocyte, Multinucleated           | 1        2  1  1        1              1  1  1        1     1            |             
      Oval Cell, Hyperplasia               | 1        1                 1           1           1              1      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Artery, Inflammation, Chronic Active |                               4                                          |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      | 1  1  1  1  1           1  1     1     2           1        1        1   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
      Artery, Inflammation, Chronic Active |                               3                             1            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                3                    2                                    |             
      Inflammation                         |                2                                                         |             
      Ulcer                                |                                                                          |             
      Artery, Inflammation, Chronic Active |                               2                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                2                                                         |             
      Artery, Inflammation, Chronic Active |                               3                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +        +  +  +     +  +  +           +        +           +|             
      Peridontal Tissue, Inflammation      | 1  1  1  1  1        1  2  2     1  1  1           1        1           1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                2                                                         |             
      Aorta, Adventitia, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1     1        1  1  1        1           1  1     1     1  1  1|             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1     2  2        2  1     1  1  1  1           1        1        2   |             
      Degeneration, Cystic                 |                3        2     3     2                    1        2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2        2              2     2                 1     3                  |             
      Hypertrophy                          | 1  1     1  2  2  1  3  2  2  4  2  3  2        2  3     2        2  2  2|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |             1        2              1              1              2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2  2                                         2           1     3|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +|             
      Hyperplasia                          |                2                                                         |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  3     2  1              2           3           3        3           3|             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Pars Distalis, Hyperplasia           |          3  2     2           2  2  1                                2   |             
      Rathke's Cleft, Pars Intermedia,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      C-Cell, Hyperplasia                  |             2           1                    2        2                  |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hypertrophy         |                1     1  1  1  2  2  2  2     3  2        1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  1  1  1  1  2  2  2  1  1  1  1  1  1  1     2  2  2  2  1  2  2  2|             
      Duct, Cyst                           | 2  2     3  2  3  2  1  2  2  1  2  2     1  3  3  3  2  2  2  1  2  3  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  4  4  4  4  4     4  4     4  4  4  4     4  4  4  4  4  4  4  4  4|             
      Cyst                                 | 2        2  2  3     3        3  3  2           2                       1|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |          3                                                               |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                       4                  |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 | 1  1  1        3        2  1     1  2  2  1     3     4  2  3     2     1|             
      Ulcer                                |                                                       3                  |             
      Endometrium, Hyperplasia, Cystic     | 2  2  2  3  2              2  4  4  2  1        2  1     2        2  2  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  3  2  1  3  3  3  3  4  3           3  3  4     3  3  2  3  3  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Lumbar, Ectasia                      |                                                                          |             
      Lumbar, Hyperplasia, Histiocytic     |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      Ectasia                              | 2                                                                        |             
      Hyperplasia, Plasma Cell             | 2        2  2     3     2  2  2  2     2           2     2  2        2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2  4  2  2  2  2  2  2  1  3  2  3  2  3  2  2  1  2  2  2|             
      Pigmentation                         | 2  2  2  2  2  2  1  2  2  1  2  2  2  3  1  2  2  2  1  1  3  2  2  2  2|             
      Lymphoid Follicle, Atrophy           |                3  2        2           2     3                 2        2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Atrophy                              | 4  2     4  3  4  2     2  4  4     2  4  2  3     2     3  4     4     2|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3                                                               |             
      Hyperplasia                          | 1  1        2        1  1  1     1     1     2     2                     |             
      Inflammation, Granulomatous          |                         2                                                |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                4         |             
      Infiltration Cellular, Histiocyte    | 2  1     1  2        1  2  2  1  2  1  1           1  1  1  2     2  2  2|             
      Inflammation                         |                            3              1                 1            |             
      Metaplasia, Squamous                 |                         1              2                                 |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                         1        2                                1      |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2        1  3                 1  2  1                 1     2        2  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1                       1  1                 2  1                  |             
      Respiratory Epithelium, Hyperplasia  |                               2  2                 2  2                 2|             
      Septum, Inflammation                 |                                  2                 1                    2|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation                         |          1                             1           1                     |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |             X           X                                                |             
      Cyst                                 |          2                                                               |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 7| 7| 6| 5| 6| 7| 6| 7| 7| 7| 7| 2| 4| 3| 7| 5| 4| 5| 3| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 2| 6| 1| 7| 0| 5| 2| 3| 2| 2| 6| 2| 3| 2| 6| 5| 8| 1| 8| 2| 2|             
                                           | 8| 9| 1| 8| 8| 8| 3| 5| 7| 1| 8| 0| 9| 6| 7| 0| 7| 8| 1| 1| 0| 5| 1| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Mineralization                       | 1     1  1  1  2  1  1  1  1  1        1  1  1  1  1  1  1     1  1  1  1|             
      Necrosis                             |                2                                                         |             
      Nephropathy                          | 1  1     2  1  3     2  1  1  2  1  1  1  1        2  2     2        1  1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Pelvis, Dilatation                   |                2                                                         |             
      Pelvis, Inflammation                 |                                     2                                    |             
      Transitional Epithelium, Hyperplasia |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1                    2                                    |             
      Transitional Epithelium, Hyperplasia |    2  2                                                                  |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
      Periesophageal Tissue, Inflammation  |                         3                                                |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   2                                                      |             
      Artery, Mineralization               |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X     X                    X           X                  |             
      Basophilic Focus, Multiple           |             X                    X                                       |             
      Cholangiofibrosis                    |                                           1              1               |             
      Clear Cell Focus, Multiple           |                X                                                         |             
      Eosinophilic Focus                   |                            X        X        X           X  X            |             
      Eosinophilic Focus, Multiple         |       X                          X                    X           X      |             
      Fatty Change, Diffuse                |                1     1  1  1  1  1           1           1        1  1   |             
      Fatty Change, Focal                  | 1                                                     1           1      |             
      Hematopoietic Cell Proliferation     | 1     1     1  1  1  1     2        1  1  1  1  1  1  1  1     1  3      |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Nodular                 |             X              X              X  X     X              X      |             
      Inflammation                         | 1  1     2  1  2        1  1  1  1  1  1  1  1  1  2  1  1  1  1     1  1|             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           |       X     X  X     X                 X  X  X     X     X           X  X|             
      Necrosis                             | 2                          2                       2              1      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         | 1     2     2  2     2  2  2  3  2  2  2  2  2     1  2  1  1     1  2  1|             
      Toxic Hepatopathy                    |       1     1  1     1     1     1  1     1  1     1  1  1        1     1|             
      Bile Duct, Cyst                      |                            2                                             |             
      Bile Duct, Fibrosis                  |       1                             1                                    |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Degeneration          | 3                    2     2                                      2      |             
      Hepatocyte, Hypertrophy              |       1              1     1              1     1  1  1  1  1     2     1|             
      Hepatocyte, Multinucleated           |             2  2     1  1     2  2  1                    1               |             
      Oval Cell, Hyperplasia               |             1        1     1     2  1                 1           1     1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |       1  1           1              2  1  1        1  1              1   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                            1                             1               |             
      Artery, Inflammation, Chronic Active |                                              2                 3         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                     3                                    |             
      Inflammation                         |                                     3                                    |             
      Ulcer                                |                                     3                                    |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                          |             
      Mineralization                       |                   2                                                      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +  +  +        +  +  +     +     +  +        +        +        +  +|             
      Peridontal Tissue, Inflammation      | 1     1  1  3        1  1  1     1     1  1        1        1        1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                   3                                                      |             
      Aorta, Adventitia, Inflammation,     |                                                                          |             
           Chronic Active                  |                                     4                                    |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1                             1              1     1     1     1   |             
      Mineralization                       |                   2                                                      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1     1  1     1        1  1        1  1     1     1           1  1|             
      Degeneration, Cystic                 |       2                       2                                   2  2  2|             
      Hematopoietic Cell Proliferation     |                                     1                                    |             
      Hyperplasia                          |                      2  2     3                          2               |             
      Hypertrophy                          | 2  2  3  2  2  3     2  2  2     1  2  1  3  2  3  1  1  3  2     2  3  3|             
      Necrosis                             | 2                                                                 2      |             
      Vacuolization Cytoplasmic            | 1     1     1        1  1  1  1              1        1  2           1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                    2                                       |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                     1                                    |             
      Pars Distalis, Hyperplasia           |       2        3           2  2              3     2                 3   |             
      Rathke's Cleft, Pars Intermedia,     |                                                                          |             
           Hyperplasia                     |       2                                                                  |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      2        1     2                 3           3      |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hypertrophy         |       2                          2  2  1  1  1     1     1  3  2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2     2  1  1  1     2        2  2  1     1  1  1  1  1  2  1  1  1  1  2|             
      Duct, Cyst                           | 2     2  3  1  1  1  2        2  3  2     2  1        3  1  1  2     2  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4     4     4  4  4|             
      Cyst                                 |                            2     1        3              2  3        2   |             
      Inflammation, Chronic Active         |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |       +                                                                  |             
      Inflammation, Chronic Active         |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Cyst                                 | 2                                                                        |             
      Hemorrhage                           | 2                                                                        |             
      Inflammation, Chronic Active         |                                        3        2     3                  |             
      Inflammation, Suppurative            | 2                 1                                2                     |             
      Metaplasia, Squamous                 |       1        1  2              2     2  1  2     2  3     2        2  2|             
      Ulcer                                | 2                                               3                        |             
      Endometrium, Hyperplasia, Cystic     | 4     3  4  1  2  1  2        2  1  2  4  3  2  4  1  4  1  1     1  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2  3  3        3  3     3        4  3  4  2  3  3  2  3  2  4  4     3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                             +                    +               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Lumbar, Ectasia                      |       2                                                                  |             
      Lumbar, Hyperplasia, Histiocytic     |       2                                                                  |             
      Mediastinal, Ectasia                 |                                     2                    1               |             
      Mediastinal, Hyperplasia, Plasma Cell|                                     3                                    |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Plasma Cell             |                         2  2  2  2  2  2  2  2  2     2  2        2  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                       3                  |             
      Hematopoietic Cell Proliferation     | 3     2     2  2  1  2     3        4  3  2  2  3  3     2     4  2  2  2|             
      Pigmentation                         | 1  2  2  2  2  2  2  1     1  3  2        2  2  2  2  1  2  2     1  2  2|             
      Lymphoid Follicle, Atrophy           |                   3           3                       3     2     2      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     2     4     3  4  2  4     3     2  4  3     2  4  3  2     4  3  3|             
      Hemorrhage                           |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              2  3        2               |             
      Hyperplasia                          |       1     1  1     1           1        1                    1     1   |             
      Inflammation, Granulomatous          |                                                          2               |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                         2                                                |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     2  1  2  2  1  2  1  2  2  2  1  1  2        2  2  2  1        2  2|             
      Inflammation                         |                      2           2        2                             2|             
      Metaplasia, Squamous                 |                            1                                             |             
      Mineralization                       |                   2                                                      |             
      Alveolar Epithelium, Hyperplasia     |       1     1                    1                       1               |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       1     2  2     2     2  2           2        1     1           2  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               1        1                                 |             
      Respiratory Epithelium, Hyperplasia  |                               2                                          |             
      Septum, Inflammation                 |                               1  1                                       |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               2                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1           1           2           1        1      |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Cyst                                 |                                                                      2   |             
      Hemorrhage                           |    2                                                                     |             
      Inflammation, Chronic Active         |                                                                   3      |             
      Inflammation, Suppurative            |                         1           1                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 6| 3| 7| 7| 3| 7| 6| 7| 7| 6| 7| 5| 7| 7| 3| 6| 5| 7| 4| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 7| 8| 2| 2| 4| 2| 4| 2| 1| 6| 2| 0| 3| 3| 5| 7| 0| 2| 5| 1| 2| 3| 3|             
                                           | 5| 1| 5| 2| 8| 8| 8| 9| 2| 1| 7| 2| 1| 0| 0| 0| 3| 5| 0| 9| 4| 3| 8| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    92 NG/KG                               | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| 8| 9| 1| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Mineralization                       | 1  1  1  1  1     2  1  1  1  1  1  1  1        1  1  1           1  1  1|             
      Necrosis                             |                   3                                                      |             
      Nephropathy                          | 1     1     1  1     1     3  1     3  1  2  1        1  2     1     1  1|             
      Artery, Inflammation, Chronic Active |                                                                2         |             
      Pelvis, Dilatation                   |                   2                                                      |             
      Pelvis, Inflammation                 |                2           2  2                                   2      |             
      Transitional Epithelium, Hyperplasia |                4     2     2  3                                   3      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1           1  2                                   2      |             
      Transitional Epithelium, Hyperplasia |                            4  2                                          |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                            2                                             |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    92 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      1  2.0|
      Periesophageal Tissue, Inflammation  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  51        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  51        |
      Inflammation                         |                                                                          |      1  2.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Basophilic Focus                     | X                                                                        |     12     |
      Basophilic Focus, Multiple           |                                                                          |      3     |
      Cholangiofibrosis                    |                                                                          |      3  1.3|
      Clear Cell Focus, Multiple           |                                                                          |      6     |
      Eosinophilic Focus                   |                                                                          |     11     |
      Eosinophilic Focus, Multiple         |       X                                                                  |     12     |
      Fatty Change, Diffuse                |    1                                                                     |     20  1.1|
      Fatty Change, Focal                  |                                                                          |      6  1.3|
      Hematopoietic Cell Proliferation     | 1  1  1                                                                  |     39  1.1|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia, Nodular                 |                                                                          |      8     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    92 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         | 1  1  1                                                                  |     48  1.2|
      Mixed Cell Focus                     |                                                                          |      2     |
      Mixed Cell Focus, Multiple           | X  X                                                                     |     25     |
      Necrosis                             |                                                                          |      6  2.0|
      Pigmentation                         | 2  2  2                                                                  |     42  1.8|
      Toxic Hepatopathy                    | 1  1  1                                                                  |     27  1.1|
      Bile Duct, Cyst                      |                                                                          |      2  2.0|
      Bile Duct, Fibrosis                  |                                                                          |      3  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  1.0|
      Centrilobular, Degeneration          |                                                                          |      4  2.3|
      Hepatocyte, Hypertrophy              | 1  1                                                                     |     24  1.0|
      Hepatocyte, Multinucleated           |                                                                          |     18  1.3|
      Oval Cell, Hyperplasia               |    2                                                                     |     15  1.1|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Hyperplasia, Squamous      |    2                                                                     |     22  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Cyst                                 | 2                                                                        |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      2  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  52        |
      Hyperplasia, Squamous                |                                                                          |      3  2.7|
      Inflammation                         |                                                                          |      2  2.5|
      Ulcer                                |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    92 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Glandular                      | +  +  +                                                                  |  52        |
      Erosion                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |  29        |
      Peridontal Tissue, Inflammation      |    1                                                                     |     29  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      2  2.5|
      Aorta, Adventitia, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |                                                                          |     18  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |    2  1                                                                  |     27  1.2|
      Degeneration, Cystic                 | 2                                                                        |     12  2.1|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |     10  2.1|
      Hypertrophy                          | 3  1  3                                                                  |     44  2.1|
      Necrosis                             |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            | 1                                                                        |     17  1.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |       1                                                                  |      7  1.9|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    92 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +                                                                  |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          | 3                                                                        |     12  2.4|
      Cyst                                 |       3                                                                  |      1  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |    3                                                                     |     15  2.3|
      Rathke's Cleft, Pars Intermedia,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      C-Cell, Hyperplasia                  |                                                                          |      9  2.0|
      Follicle, Cyst                       |    2                                                                     |      1  2.0|
      Follicular Cell, Hypertrophy         | 1  1  1                                                                  |     24  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  50        |
      Inflammation                         | 2  3  2                                                                  |     47  1.5|
      Duct, Cyst                           | 3  3  1                                                                  |     44  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
      Atrophy                              | 4  4  4                                                                  |     45  4.0|
      Cyst                                 | 3     3                                                                  |     18  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    92 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Adenomyosis                          |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      4  3.0|
      Inflammation, Suppurative            |                                                                          |      3  1.7|
      Metaplasia, Squamous                 | 3  1  2                                                                  |     31  1.9|
      Ulcer                                |                                                                          |      3  2.7|
      Endometrium, Hyperplasia, Cystic     | 3  1  2                                                                  |     39  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 3  3  3                                                                  |     42  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Lumbar, Ectasia                      |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Histiocytic     |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      2  1.5|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 3  3  2                                                                  |     30  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 2  2  2                                                                  |     46  2.2|
      Pigmentation                         | 2  2  2                                                                  |     49  1.9|
      Lymphoid Follicle, Atrophy           |                                                                          |     12  2.4|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    92 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  | +  +  +                                                                  |  49        |
      Atrophy                              | 3  3  4                                                                  |     39  3.1|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      4  2.5|
      Hyperplasia                          | 2  1                                                                     |     20  1.2|
      Inflammation, Granulomatous          | 2     2                                                                  |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    | 1  2  2                                                                  |     41  1.6|
      Inflammation                         |                                                                          |      7  1.9|
      Metaplasia, Squamous                 |       2                                                                  |      4  1.5|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |      8  1.1|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |    1  1                                                                  |     23  1.6|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    92 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      7  1.1|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      6  2.0|
      Septum, Inflammation                 |                                                                          |      5  1.4|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      8  1.1|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      2     |
      Cyst                                 |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Mineralization                       | 1  1  1                                                                  |     43  1.0|
      Necrosis                             |                                                                          |      2  2.5|
      Nephropathy                          | 3  1                                                                     |     36  1.4|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Pelvis, Dilatation                   |                                                                          |      2  2.0|
      Pelvis, Inflammation                 |                                                                          |      5  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      6  2.7|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 2| 2| 6|                                                                 |            |
                                           | 8| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    92 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Urinary Bladder                         | +  +  +                                                                  |  51        |
      Inflammation                         |                                                                          |      6  1.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      4  2.5|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Basophilic Focus                     |                                                    X  X                  |             
      Basophilic Focus, Multiple           |       X                                                                  |             
      Cholangiofibrosis                    |                                                             1            |             
      Clear Cell Focus                     |                                                 X                    X   |             
      Clear Cell Focus, Multiple           |          X     X  X        X  X                                          |             
      Degeneration, Cystic                 |       1                                                                  |             
      Eosinophilic Focus                   |    X     X                                            X           X     X|             
      Eosinophilic Focus, Multiple         |             X  X     X  X              X           X                     |             
      Fatty Change, Diffuse                |       2     1              1  2  1  1     1  2  1  1  1  1               |             
      Fatty Change, Focal                  |                      1                                            1      |             
      Hematopoietic Cell Proliferation     | 1           1     1  1  1  1        1  1  1     1  1  1              1  2|             
      Hepatodiaphragmatic Nodule           |                                     X                                    |             
      Hyperplasia, Nodular                 |       X  X           X                          X  X  X              X   |             
      Inflammation                         | 1  2  1  1  1  1  1  1  2  2  1  1  1  2  2     1  1  2  1  1  1  1  1  2|             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           |       X  X     X  X        X  X     X     X     X  X  X  X  X        X   |             
      Necrosis                             |    3        2        2  1              2                    1        2  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         | 2        3  1  1  2  2  2  2  3  2  2     2  2  2  2  1  2  2     2  1  2|             
      Toxic Hepatopathy                    | 1  2  2  2  2     2  3     2  2  1  1     2     1  2  2  2  1     1  2   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Bile Duct, Cyst                      |       2                             1     2                              |             
      Bile Duct, Fibrosis                  |                2                 1        1              1               |             
      Bile Duct, Hyperplasia               |       2  1           1              1     2                              |             
      Centrilobular, Degeneration          |             1        3                                                   |             
      Hepatocyte, Hypertrophy              | 1     1  1  2        3              1     2     1  1     1  1     1  1   |             
      Hepatocyte, Multinucleated           |    2  2  1  1        1  1  1  1  1  1     1     1  1  1  1        2     2|             
      Oval Cell, Hyperplasia               | 2  1  2  1        2  2  1  1        1     2     1  2  1           1  2   |             
      Portal, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                                +              +                    +   |             
      Artery, Inflammation, Chronic Active | 3                                3              3                    4   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |          1        1                 2           1     2     1     1      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               | 2                                2  2                                    |             
      Inflammation, Chronic Active         |                                              1                           |             
      Acinus, Atrophy                      |                                              2                           |             
      Acinus, Vacuolization Cytoplasmic    | 2     1     1  1  1                 1     1     1        1           1   |             
      Artery, Inflammation, Chronic Active | 3              3                 3              3                    3   |             
      Duct, Dilatation                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   1                                                      |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          3               |             
      Hyperplasia, Squamous                |                   2  3                       2  1        3              2|             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                           1                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +        +        +  +     +     +     +  +  +  +  +     +  +   |             
      Peridontal Tissue, Inflammation      |          1        1        1  1     1     1     2  2  2  1  1     1  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1  1  1                 2  1           1     1     1     1  1   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                   1                                                      |             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                                        2  1                              |             
      Epicardium, Inflammation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2        2     1  1  1     2  2     1     2           1  1  1     1  1   |             
      Atrophy                              |       4                                         2        1               |             
      Degeneration, Cystic                 |       3  2                       3        2     3  2  2           3      |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hyperplasia                          |                                     2                                2  2|             
      Hypertrophy                          | 1     3  2     2  1  2  3  2  1  3  2     3     4  3  2  2  2     3  1  2|             
      Vacuolization Cytoplasmic            |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       3  1               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                          3                        |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Angiectasis                          | 2     3     2  2                 3              2     1     1            |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |             4  4  2  1           3        2           4  3               |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3              2  2  2  2     1     1                                    |             
      Follicular Cell, Hypertrophy         | 1        2  1           1  1        2           2        2  3     2  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    2  2  1  2  2  2  1  1  2  2  1  1     1  1  1  1  2  1  1     1     1|             
      Duct, Cyst                           | 1     3  2  2     3  3  1  2  3  3        2  3  4     2  2  3  3  3     2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4  4  4  4  4  4  4     4  3  4  4  4  4     4  4  4        4  4|             
      Cyst                                 |    2                                2        2  3  3              4      |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   2      |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |    1                                                     1  1            |             
      Metaplasia, Squamous                 |       2  2  2  3        2  1        3  2  1     3  2  1  2  3     4  1  1|             
      Ulcer                                |                                                                   2      |             
      Cervix, Cyst                         |                                                 3                        |             
      Endometrium, Hyperplasia, Cystic     | 2  4  2  2  2  4  2  1  2  2     1        3  2  1  4  2              1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  3        3  3  3  3  3        3  3  3     3  3  3        3     2  3  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                                                                    +  +|             
      Hyperplasia, Plasma Cell             | 2                                                                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                      2  1|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2     2  3  2  3  2     2     2           3     2  2  3  2  2     2  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       2                                                                  |             
      Hyperplasia, Histiocytic             |       2                                                                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hematopoietic Cell Proliferation     | 3  2  2  2  3  2  2  3  3  1  2  1  2  2  2     2  2  2  2  2  1  1  2   |             
      Pigmentation                         | 1  3  2  2  2  2  2  2  2  2  2  3  2  2  2  1  2  2  3  2  2  2  1  1   |             
      Lymphoid Follicle, Atrophy           |    2        2                    3           2                           |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  2  3  4  4  4  4  4  3  3  3     4     4  4  4     4  3  4     4  3  2|             
      Hemorrhage                           |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3                                                                        |             
      Hyperplasia                          | 1        1  1        1        2  2        1  1                 1  1  1   |             
      Inflammation, Granulomatous          | 2                                                           2            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Conjunctiva, Inflammation            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              3                           |             
      Hydrocephalus                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Radicular Neuropathy                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1     2  1  1  2  1  2     1  1     2     2     1  2     1  1     1  2   |             
      Inflammation                         | 1  1              1     1  2     3                             3         |             
      Metaplasia, Squamous                 |                   2                                2                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                   1  1   |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       2  1  1  2  2  2     1        2     3     1  3     1  2        1   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1                                                   |             
      Respiratory Epithelium, Hyperplasia  |                                                       2                  |             
      Respiratory Epithelium, Metaplasia   |                                                                          |             
      Septum, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Artery, Peritracheal Tissue,         |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 0| 5| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 3| 1| 2| 2| 0| 4| 2| 2| 5| 0| 9| 2| 0| 2| 2| 2| 2| 3| 7| 1| 3| 2|             
                                           | 4| 6| 9| 0| 3| 9| 8| 6| 2| 8| 8| 9| 3| 7| 9| 8| 9| 8| 8| 9| 0| 8| 3| 0| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    NG/KG                                  | 6| 7| 0| 6| 7| 8| 9| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Inflammation                         |                               1              1                    1      |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                      X     X                                             |             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         | 1                                                                        |             
      Inflammation, Suppurative            |                                                       1     2            |             
      Mineralization                       |    1        1        1  1  1     2  1  1        1        1  1  1     1   |             
      Nephropathy                          | 3  1  2  1  1  3     1  1  1  1  2     1  1  1  2  1     1  1     1  3   |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                   2                                                      |             
      Renal Tubule, Nephropathy            |                                                       1                  |             
      Transitional Epithelium, Hyperplasia |                1  2        1                                             |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphoid      |                                                                          |             
      Inflammation                         |                   2                                                      |             
      Transitional Epithelium, Hyperplasia |                   2        1              1                              |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |          2                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X                 X  X                       X                           |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cholangiofibrosis                    |             4                                                        1   |             
      Clear Cell Focus                     |                                                    X                     |             
      Clear Cell Focus, Multiple           |                                        X     X                           |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   | X                       X                                X     X  X      |             
      Eosinophilic Focus, Multiple         |    X     X  X  X              X  X  X     X     X                    X   |             
      Fatty Change, Diffuse                | 1        1                 2     1        2  1        1     1  2  1  1  1|             
      Fatty Change, Focal                  |                      1              1                                    |             
      Hematopoietic Cell Proliferation     | 1  2  1  1     1  1        1  1     1  1  1     1        2  1        1   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Nodular                 |    X           X                 X                                   X   |             
      Inflammation                         | 1  2     1  2  2  2  1  2  1  1  1  1  1  2  1  1  1  1  1     2  1  1  2|             
      Mixed Cell Focus                     |                                                       X                  |             
      Mixed Cell Focus, Multiple           | X                    X                 X     X  X  X        X     X     X|             
      Necrosis                             |    2  2     1  1           2  2  1        3                             1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         | 2  3     2  1  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2|             
      Toxic Hepatopathy                    | 1  2     1  3  2  1  1  1        2  2  1  3  2  1  1  2  1  2  1  1  2  1|             
      Artery, Inflammation, Chronic Active |                                                                      1   |             
      Bile Duct, Cyst                      |    2                       2                                      2      |             
      Bile Duct, Fibrosis                  |                               1                                          |             
      Bile Duct, Hyperplasia               |             3     1     1        2           1                          1|             
      Centrilobular, Degeneration          |    2                                      3              3               |             
      Hepatocyte, Hypertrophy              | 1  2     1  1  1  1  1  1        1  1  1  1  1  1           1  1  1  2  1|             
      Hepatocyte, Multinucleated           |    1     1  1  1  1     2     1  1  1     1              2  1  2     1  1|             
      Oval Cell, Hyperplasia               |    2        3     1     1        2  1  1  1  1  1  1  1     1  1  1  2  1|             
      Portal, Fibrosis                     |             1                                                            |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |             1  1     1  2     2     3  1  1  1     1                 2  1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Chronic Active         |             2                                               3            |             
      Acinus, Atrophy                      |                                                             3            |             
      Acinus, Vacuolization Cytoplasmic    |    1                    1     1     1  2  1     1  1        1  1  1      |             
      Artery, Inflammation, Chronic Active |             4                    4     4        3  4                     |             
      Duct, Dilatation                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Squamous                |                                                          2     3     1   |             
      Inflammation                         |                                                                      2   |             
      Ulcer                                |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                 2                    3   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                2                                                        1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +     +     +     +  +     +  +  +  +  +  +     +     +  +        +   |             
      Peridontal Tissue, Inflammation      |    1     1     1     1  1     2  3  1  1  1  1     1     3  1        2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1              1        2        1     1  1     1  1  1     1   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Epicardium, Inflammation             |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  1     2  2     1  2        1     1  2     1  1  1  1     1  1  2  1  2|             
      Atrophy                              |                                                                          |             
      Degeneration, Cystic                 | 2           2                                2  2     2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 1                          1        2  2        2     2     2        2   |             
      Hypertrophy                          | 2        2  3  1  1  3  1  1  2  3  1  2  2  3  2  2  3     2  2  2  2  1|             
      Vacuolization Cytoplasmic            |    1        1        2           2     1  1  2              1        2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1        2     1  1              2     2                    3   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Angiectasis                          |          3                       2                 1           3         |             
      Cyst                                 |                                                                         2|             
      Pars Distalis, Hyperplasia           | 3                 2        2        2     2  3        3     2     2  2  3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                     1  2  2                              |             
      Follicular Cell, Hypertrophy         |    2                 1  2     2     1  1     1  1  1                    1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  2  1  1  3  1     1  2  1  1  2  2  3  1  2  2  2  1     2  3  1  1  1|             
      Duct, Cyst                           |          2  2  1  2     2  1  1  2  2  2  2  2  1           3  2  2  3  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4  4  4  4  4  4  4     4  4  4  4  4  2  4     4|             
      Cyst                                 |                   2                          2              2  2     2   |             
      Inflammation, Chronic Active         | 4                                                                        |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                             |             
      Inflammation, Chronic Active         |                         2  3     2                                       |             
      Inflammation, Suppurative            |                                                 1                        |             
      Metaplasia, Squamous                 | 1     1           2  1  4        3  2  2     2  3  1  1  1  1  3  2     1|             
      Ulcer                                |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 1  2        1     1        4  4  2  1  2  1  1  2  3  3     3  2  3  1  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  3  3  3  2  3  3  3        2  2  2  1  4     3  2  2  4  2  2  3  4  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +                             +                       +           +   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                  2                                       |             
      Mediastinal, Ectasia                 |    2                                                                 2   |             
      Mediastinal, Hemorrhage              |                                                                      1   |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                        2                                 |             
      Hyperplasia, Lymphoid                | 4                                                                        |             
      Hyperplasia, Plasma Cell             | 2              2     2              2  2  2  2  2  2     2           2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                  3                                       |             
      Hyperplasia, Plasma Cell             |                                           2                              |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  3     2  2  3  2  1  2  3  1  1  2  2  3  2  2  2  2  4  2  1  2  1  2|             
      Pigmentation                         | 2  1     1  2  1  2  2  2  2  3  1  2  2  1  2  2  1  2  1  3  3  3  1  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  3  3  4  3  3  4  4  3  4  4  3  4  4     4  4  4  3  4  4  4  4  2|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 2  2                     |             
      Hyperplasia                          |                                           1           1              1  1|             
      Inflammation, Granulomatous          | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Conjunctiva, Inflammation            |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                2         |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                               +                                          |             
      Radicular Neuropathy                 |                               2                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                               +                                          |             
      Degeneration                         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    2     2  2           2        2     2  2  2  1  1  2     1  2  2  2  1|             
      Inflammation                         |             1                                                            |             
      Metaplasia, Squamous                 |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |          2                       1  1  1  1  2        1     1  1  1  2   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1                                                  2  2           1  1|             
      Respiratory Epithelium, Hyperplasia  |                                                       2     2            |             
      Respiratory Epithelium, Metaplasia   |                                                       2                  |             
      Septum, Inflammation                 |                                                       2  2  1            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                  2                                       |             
      Artery, Peritracheal Tissue,         |                                                                          |             
          Inflammation, Chronic Active     |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Inflammation                 |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 5| 5| 4| 4| 5| 4| 4| 4| 6| 5| 7| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 2| 1| 9| 7| 8| 9| 4| 7| 5| 1| 9| 6| 7| 2| 2| 2| 8| 2| 2| 4| 2| 4| 3| 3| 9|             
                                           | 8| 6| 8| 7| 6| 8| 2| 0| 1| 2| 8| 8| 0| 8| 4| 9| 9| 8| 8| 3| 9| 9| 0| 0| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200                                    | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Inflammation                         |                1     1                                               1   |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                X                                                         |             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                           3                              |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1  1  1  1     1              1  1  1        1  1     1  1  1  1  1     1|             
      Nephropathy                          | 1  1  1  1  1     1  2  1  1  1  1  1  2  1  1  2  2  1     3  2  1  2   |             
      Pelvis, Dilatation                   |                                           3                              |             
      Pelvis, Inflammation                 |                                                                          |             
      Renal Tubule, Nephropathy            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                              2                           |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphoid      |                                                                          |             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    200                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Inflammation                         |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
      Artery, Inflammation, Chronic Active |       2                                                                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      6     |
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Cholangiofibrosis                    | 2  3                                                                     |      5  2.2|
      Clear Cell Focus                     |                                                                          |      3     |
      Clear Cell Focus, Multiple           |    X                                                                     |      8     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |     10     |
      Eosinophilic Focus, Multiple         | X     X                                                                  |     18     |
      Fatty Change, Diffuse                | 2  2                                                                     |     26  1.3|
      Fatty Change, Focal                  |                                                                          |      4  1.0|
      Hematopoietic Cell Proliferation     | 1  1                                                                     |     31  1.1|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia, Nodular                 | X                                                                        |     12     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    200                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         | 1  1  1                                                                  |     50  1.3|
      Mixed Cell Focus                     |                                                                          |      1     |
      Mixed Cell Focus, Multiple           | X  X                                                                     |     25     |
      Necrosis                             |       2                                                                  |     18  1.8|
      Pigmentation                         | 2  2  2                                                                  |     48  1.9|
      Toxic Hepatopathy                    | 2  3  3                                                                  |     44  1.7|
      Artery, Inflammation, Chronic Active |                                                                          |      1  1.0|
      Bile Duct, Cyst                      | 1                                                                        |      7  1.7|
      Bile Duct, Fibrosis                  |       2                                                                  |      6  1.3|
      Bile Duct, Hyperplasia               |    2  3                                                                  |     13  1.6|
      Centrilobular, Degeneration          |                                                                          |      5  2.4|
      Hepatocyte, Hypertrophy              | 1     3                                                                  |     34  1.2|
      Hepatocyte, Multinucleated           | 1  1  2                                                                  |     35  1.2|
      Oval Cell, Hyperplasia               | 1  2  3                                                                  |     35  1.4|
      Portal, Fibrosis                     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Artery, Inflammation, Chronic Active |                                                                          |      4  3.3|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Hyperplasia, Squamous      | 1                                                                        |     20  1.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Cytoplasmic Alteration               |                                                                          |      3  2.0|
      Inflammation, Chronic Active         |       2                                                                  |      4  2.0|
      Acinus, Atrophy                      |       3                                                                  |      3  2.7|
      Acinus, Vacuolization Cytoplasmic    | 1  1                                                                     |     23  1.1|
      Artery, Inflammation, Chronic Active |       2                                                                  |     11  3.3|
      Duct, Dilatation                     |       4                                                                  |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
      Atrophy                              |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    200                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia, Squamous                | 2                                                                        |     10  2.1|
      Inflammation                         | 2                                                                        |      2  2.0|
      Ulcer                                | 2                                                                        |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |       2                                                                  |      4  1.5|
      Artery, Inflammation, Chronic Active |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |  29        |
      Peridontal Tissue, Inflammation      | 1                                                                        |     29  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Cardiomyopathy                       |    1  1                                                                  |     24  1.1|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Mineralization                       |       2                                                                  |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      2  1.5|
      Epicardium, Inflammation             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 1  2  1                                                                  |     35  1.3|
      Atrophy                              |    2                                                                     |      4  2.3|
      Degeneration, Cystic                 |    3                                                                     |     14  2.4|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |     11  1.8|
      Hypertrophy                          | 2  4  2                                                                  |     45  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    200                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Vacuolization Cytoplasmic            |                                                                          |      9  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |       3                                                                  |     10  1.9|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          | 3     3                                                                  |     14  2.2|
      Cyst                                 |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     19  2.6|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      C-Cell, Hyperplasia                  |    2                                                                     |     11  1.8|
      Follicular Cell, Hypertrophy         | 1                                                                        |     22  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 1  1  1                                                                  |     47  1.5|
      Duct, Cyst                           | 1  3  2                                                                  |     40  2.2|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4     4                                                                  |     45  3.9|
      Cyst                                 | 3     3                                                                  |     13  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 121                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    200                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Uterus                                  | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      4  1.0|
      Metaplasia, Squamous                 | 1                                                                        |     35  1.9|
      Ulcer                                |                                                                          |      1  2.0|
      Cervix, Cyst                         |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2                                                                        |     37  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 3     2                                                                  |     41  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   7        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      2  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  1.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Hyperplasia, Plasma Cell             | 2  3                                                                     |     29  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  51        |
      Hematopoietic Cell Proliferation     | 2  2  2                                                                  |     50  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 122                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    200                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pigmentation                         | 2  2  2                                                                  |     51  1.9|
      Lymphoid Follicle, Atrophy           |                                                                          |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  51        |
      Atrophy                              | 4  2  4                                                                  |     48  3.6|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      3  2.3|
      Hyperplasia                          | 1  1                                                                     |     17  1.1|
      Inflammation, Granulomatous          |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Conjunctiva, Inflammation            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Radicular Neuropathy                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 123                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    200                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  52        |
      Infiltration Cellular, Histiocyte    | 2  2  1                                                                  |     36  1.6|
      Inflammation                         |                                                                          |      8  1.6|
      Metaplasia, Squamous                 |                                                                          |      3  1.7|
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |      3  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 3  1  1                                                                  |     28  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      6  1.3|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      3  2.0|
      Respiratory Epithelium, Metaplasia   |                                                                          |      1  2.0|
      Septum, Inflammation                 |                                                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  2.0|
      Artery, Peritracheal Tissue,         |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
      Cornea, Inflammation                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 124                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 9| 8| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    200                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 5| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Cyst                                 | 2                                                                        |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      2  1.5|
      Mineralization                       | 1     3                                                                  |     31  1.1|
      Nephropathy                          | 2  2  4                                                                  |     45  1.5|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Pelvis, Inflammation                 |                                                                          |      1  2.0|
      Renal Tubule, Nephropathy            |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |       4                                                                  |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Infiltration Cellular, Lymphoid      |       3                                                                  |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |       2                                                                  |      4  1.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 125                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 5| 7| 7| 2| 7| 6| 7| 7| 6| 6| 6| 7| 6| 7| 5| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 1| 0| 2| 2| 7| 3| 0| 2| 1| 1| 9| 1| 2| 3| 2| 0| 2| 2| 1| 0| 2| 1| 0|             
                                           | 0| 4| 6| 3| 8| 8| 6| 0| 5| 8| 6| 0| 9| 0| 8| 8| 8| 0| 8| 8| 5| 0| 5| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    200 NG/                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                            X               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            X                             X               |             
      Basophilic Focus, Multiple           |                                           X  X                    X     X|             
      Cholangiofibrosis                    |       4                                               1                  |             
      Clear Cell Focus                     |                                                 X     X                  |             
      Clear Cell Focus, Multiple           |                X                                         X               |             
      Degeneration, Cystic                 |                                                          2               |             
      Eosinophilic Focus                   |                                                 X                 X     X|             
      Eosinophilic Focus, Multiple         | X     X     X              X     X     X                                 |             
      Fatty Change, Diffuse                |          1              1                 2           1  1               |             
      Fatty Change, Focal                  |       1                       1  2                                1      |             
      Hematopoietic Cell Proliferation     | 1  1  1     1  1        1  1  1  1  1  1  1     1  1              1  2   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation                         | 2  1  1  1  1  1  1  1  1  1     1  1  1  1  2  1  2  1  1     1  1  1  1|             
      Mixed Cell Focus                     |                                                                      X   |             
      Mixed Cell Focus, Multiple           |       X              X     X  X  X     X        X     X  X               |             
      Necrosis                             | 2  2                             2                 3                    2|             
      Pigmentation                         | 1  2  2  1  2  1  1  2  1  1  2  1  3  1  2  2  2  2  2  2     1  2  2  2|             
      Toxic Hepatopathy                    |       1     1                    1        1     1     1  1              1|             
      Bile Duct, Cyst                      |                                                                         3|             
      Bile Duct, Fibrosis                  |             1                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 126                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 5| 7| 7| 2| 7| 6| 7| 7| 6| 6| 6| 7| 6| 7| 5| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 1| 0| 2| 2| 7| 3| 0| 2| 1| 1| 9| 1| 2| 3| 2| 0| 2| 2| 1| 0| 2| 1| 0|             
                                           | 0| 4| 6| 3| 8| 8| 6| 0| 5| 8| 6| 0| 9| 0| 8| 8| 8| 0| 8| 8| 5| 0| 5| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    200 NG/                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Hyperplasia               |             2                                                            |             
      Centrilobular, Degeneration          |    3                             3        2     2  3                     |             
      Hepatocyte, Hypertrophy              |    1     1  1        1  1     1  1     1                       1         |             
      Hepatocyte, Multinucleated           |    2              1           1     2  1  1  1  2  1  1  1        1      |             
      Oval Cell, Hyperplasia               |                                                       1                 1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Inflammation, Chronic Active         |          3                                                               |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |       1  3                                   1           1              1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Acinus, Vacuolization Cytoplasmic    | 1                                1                                       |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       | 2                                                                        |             
      Hyperplasia, Squamous                | 3           2                             2                              |             
      Inflammation                         | 3                                                                        |             
      Ulcer                                | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                          1  2           1|             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +     +     +              +     +     +  +     +  +     +  +     +|             
      Peridontal Tissue, Inflammation      |       1     1     1              1     1     2  1     2  1     1  1     1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1  1           1  1                 1     1        1           2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 127                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 5| 7| 7| 2| 7| 6| 7| 7| 6| 6| 6| 7| 6| 7| 5| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 1| 0| 2| 2| 7| 3| 0| 2| 1| 1| 9| 1| 2| 3| 2| 0| 2| 2| 1| 0| 2| 1| 0|             
                                           | 0| 4| 6| 3| 8| 8| 6| 0| 5| 8| 6| 0| 9| 0| 8| 8| 8| 0| 8| 8| 5| 0| 5| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    200 NG/                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          | 2                 1  2     1  2     1  1  2     1     2  2     2         |             
      Degeneration, Cystic                 |    2  1        2     2              2     1     2     2        3         |             
      Hyperplasia                          | 2                                            3                           |             
      Hypertrophy                          |    2  3        2     2  1  2  2  2  3  1  3     3  1  3  3     3     2  2|             
      Necrosis                             |                         2                                            2  3|             
      Vacuolization Cytoplasmic            |                            1              1           1              1   |             
      Bilateral, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          | 3                                      2              1  1               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Fibrosis                             |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3              2     3        2              2                 2  2|             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                              2                           |             
      Vacuolization Cytoplasmic            |                                                       2                  |             
      Pars Distalis, Hyperplasia           |    2                 4  2        2        2  3  2  3  2        1     4   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2  2              2              1  1        1        2              3|             
      Follicular Cell, Hypertrophy         | 2  2  1     1     2        1     1     1  1        1           1     1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  1  2     1  2  1  3  2  3  2  1  2  2  1  1  2  1  1  3  1  1  2  2  3|             
      Duct, Cyst                           | 1  2  4        2     3  2  3  3     2  1  1  1  3     3     2     2  2  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 128                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 5| 7| 7| 2| 7| 6| 7| 7| 6| 6| 6| 7| 6| 7| 5| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 1| 0| 2| 2| 7| 3| 0| 2| 1| 1| 9| 1| 2| 3| 2| 0| 2| 2| 1| 0| 2| 1| 0|             
                                           | 0| 4| 6| 3| 8| 8| 6| 0| 5| 8| 6| 0| 9| 0| 8| 8| 8| 0| 8| 8| 5| 0| 5| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    200 NG/                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Atrophy                              |    4  4  4  4  4  4  4  4  4        4  4  4  4  4  4     4     4     4  4|             
      Cyst                                 |    2                    2           3           3     3              1   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Congestion                           |          2                                                               |             
      Hemorrhage                           |       2                                                                  |             
      Inflammation, Chronic Active         |       1  3     1  1     3                             3                  |             
      Inflammation, Suppurative            |                                                                      2  1|             
      Metaplasia, Squamous                 |       4     1  4        4  2           2  1     1  2  3  2     2     2   |             
      Endometrium, Hyperplasia, Cystic     |    4     4  3     4  3     2  2     2  1     1        1  1  4  2     4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  3  4  4  2  2  3     3  2  4  3     3  3  3  3  3  2     3  3  3  4  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +        +                          +                              |             
      Iliac, Ectasia                       |       3                                                                  |             
      Iliac, Hyperplasia, Plasma Cell      |       3                                                                  |             
      Lumbar, Ectasia                      |                2                                                         |             
      Lumbar, Hyperplasia, Plasma Cell     |                                           3                              |             
      Renal, Ectasia                       |                2                                                         |             
      Renal, Hyperplasia, Plasma Cell      |                2                                                         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2     2  2     1  2  2        2  2  2  2  2  2        2        2  2  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  2  3  2  2  2  1  2  3  2  3  2  2  2  3  2  3  3  2  2     2  2  2  3|             
      Pigmentation                         | 1  2  1  1  2  2  2  2     2  1  1  2  1  1  2  1  1  2  2     2  2  2  2|             
      Lymphoid Follicle, Atrophy           |                                                                   2      |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 129                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 5| 7| 7| 2| 7| 6| 7| 7| 6| 6| 6| 7| 6| 7| 5| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 1| 0| 2| 2| 7| 3| 0| 2| 1| 1| 9| 1| 2| 3| 2| 0| 2| 2| 1| 0| 2| 1| 0|             
                                           | 0| 4| 6| 3| 8| 8| 6| 0| 5| 8| 6| 0| 9| 0| 8| 8| 8| 0| 8| 8| 5| 0| 5| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    200 NG/                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy                              | 2  2  3  4  4  4  2  4  3  4  3  3  4  3  2  4  4  2  4  4     3     4  2|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                      3                             2|             
      Hyperplasia                          |       1                 1  1  2  2        2  1                       3  3|             
      Inflammation, Granulomatous          |    2                                                                     |             
      Inflammation                         |                                           3                              |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Lip, Inflammation, Chronic Active    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                2         |             
      Infiltration Cellular, Histiocyte    |          1  1     2  1  1  1  1  1     1  2  1     2  1  1        2     1|             
      Inflammation                         |                      2        2     2                                    |             
      Metaplasia, Squamous                 |                                        3                                 |             
      Mineralization                       |                                                                      2   |             
      Alveolar Epithelium, Hyperplasia     |             1                                                            |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |             1                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 130                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 5| 7| 7| 2| 7| 6| 7| 7| 6| 6| 6| 7| 6| 7| 5| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 7| 8| 1| 0| 2| 2| 7| 3| 0| 2| 1| 1| 9| 1| 2| 3| 2| 0| 2| 2| 1| 0| 2| 1| 0|             
                                           | 0| 4| 6| 3| 8| 8| 6| 0| 5| 8| 6| 0| 9| 0| 8| 8| 8| 0| 8| 8| 5| 0| 5| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    200 NG/                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    KG STOP                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1                             1     1                                    |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                         2|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 1              1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Accumulation, Hyaline Droplet        |    2           2                                                     2   |             
      Calculus Micro Observation Only      |    X                                                                     |             
      Infarct                              |                                                    3                     |             
      Inflammation                         |                                                                      4   |             
      Inflammation, Suppurative            |                                                       1  1               |             
      Mineralization                       | 1  1  1     1  1  1  1  1     1  1  1  1  1  1  1     1        1  1     1|             
      Nephropathy                          |    1  1  1  1  1  1  1     1     1  1     1     1     1  1     1  1     1|             
      Pelvis, Dilatation                   |                                                                      3   |             
      Pelvis, Inflammation                 |                                                 2                        |             
      Transitional Epithelium, Hyperplasia |             1                                   2                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 3  3                     |             
      Transitional Epithelium, Hyperplasia |                                                 2  2                 1   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 131                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 6| 4| 6| 6| 7| 5| 4| 5| 6| 2| 6| 4| 4| 4| 5| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 1| 3| 8| 1| 6| 8| 2| 2| 9| 1| 5| 4| 9| 5| 5| 9| 4| 2| 2| 7| 2| 2| 1|            |
                                           | 9| 9| 9| 0| 0| 3| 7| 9| 8| 5| 1| 2| 1| 0| 2| 1| 1| 5| 7| 9| 8| 6| 9| 8| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    200 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       2                  |      1  2.0|
      Basophilic Focus                     |          X                       X        X  X  X                 X     X|      9     |
      Basophilic Focus, Multiple           |                                                                          |      4     |
      Cholangiofibrosis                    |                                           3                              |      3  2.7|
      Clear Cell Focus                     |    X                    X                                                |      4     |
      Clear Cell Focus, Multiple           |                                                                          |      2     |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Eosinophilic Focus                   |          X  X              X                          X           X      |      8     |
      Eosinophilic Focus, Multiple         |       X           X  X           X        X  X              X           X|     14     |
      Fatty Change, Diffuse                |                1                                                         |      6  1.2|
      Fatty Change, Focal                  |                                                             1  1  1      |      7  1.1|
      Hematopoietic Cell Proliferation     | 1  1  1  1        1  1     1  1        2     1  1        1  1     1     1|     31  1.1|
      Hepatodiaphragmatic Nodule           |                         X                                                |      1     |
      Inflammation                         | 1  1  1  1  1  2  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     48  1.1|
      Mixed Cell Focus                     |             X        X                                               X  X|      5     |
      Mixed Cell Focus, Multiple           | X  X  X  X              X                 X  X  X           X     X      |     19     |
      Necrosis                             |             2  1              3  3     2     1                           |     11  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 132                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 11:23:31    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 6| 4| 6| 6| 7| 5| 4| 5| 6| 2| 6| 4| 4| 4| 5| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 1| 2| 1| 3| 8| 1| 6| 8| 2| 2| 9| 1| 5| 4| 9| 5| 5| 9| 4| 2| 2| 7| 2| 2| 1|            |
                                           | 9| 9| 9| 0| 0| 3| 7| 9| 8| 5| 1| 2| 1| 0| 2| 1| 1| 5| 7| 9| 8| 6| 9| 8| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    200 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    KG STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Pigmentation                         | 1  1  1  1  2  3  2  2  1     2  1  2  1  2  1  1  2  1  1  2  2  2  2  2|     48  1.6|
      Toxic Hepatopathy                    |                                           1                              |      9  1.0|
      Bile Duct, Cyst                      |                         1                                                |      2  2.0|
      Bile Duct, Fibrosis                  |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Centrilobular, Degeneration          |                1                       3                                 |      7  2.4|
      Hepatocyte, Hypertrophy              |          1           1     1           1              1                  |     14  1.0|
      Hepatocyte, Multinucleated           |       1     1  1  2           2  2        1  1  1           1  1  1  1   |     25  1.2|
      Oval Cell, Hyperplasia               |                      1                                                   |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                         +