National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4873

TDMS Study 96007-01 Pathology Tables

NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:22:01

                                                          14 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57465-28-8

       Lock Date:  01/09/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     05/28/98 - 05/29/98

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    10 NG/KG
                               Include 003    30 NG/KG
                               Include 004    100     NG/KG
                               Include 005    175     NG/KG
                               Include 006    300     NG/KG
                               Include 007    550     NG/KG
                               Include 008    1000    NG/KG


























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:22:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      10 NG/KG     30 NG/KG     100          175          300          
                                                                                             NG/KG        NG/KG        NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           48           98           98           98           98           
                                                                                                                                    
  Scheduled Sacrifice                                 16           16           15           16           16           16           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10            9           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (9)          (10)         (10)         (10)         
      Clear Cell Focus                                                                                                  1           
      Inflammation                                    10 [1.3]      9 [1.1]      7 [1.0]     10 [1.2]     10 [1.2]     10 [1.3]     
      Mixed Cell Focus                                                                                     1                        
      Hepatocyte, Hypertrophy                                                    3 [1.0]      3 [1.0]      3 [1.0]      6 [1.0]     
   Pancreas                                           (10)         (10)         (9)          (10)         (10)         (10)         
      Acinus, Atrophy                                                                                                   1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (9)          (10)         (10)         (10)         
      Hypertrophy                                      3 [1.7]                                                                      
      Vacuolization Cytoplasmic                                                               1 [1.0]                               
   Pituitary Gland                                    (10)                                                                          
      Cyst                                             1 [1.0]                                                                      
   Thyroid Gland                                      (10)         (2)          (4)          (3)          (3)          (4)          
      Follicular Cell, Hypertrophy                                  2 [1.5]      4 [1.0]      3 [1.3]      3 [1.3]      4 [1.3]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:22:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      10 NG/KG     30 NG/KG     100          175          300          
                                                                                             NG/KG        NG/KG        NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (9)          (10)         (10)         (10)         
      Atrophy                                          1 [3.0]                                             1 [4.0]      2 [4.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                                          
      Pigmentation                                     9 [1.7]                                                                      
   Thymus                                             (10)         (10)         (9)          (10)         (10)         (10)         
      Cyst                                                                                                 1                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (9)          (10)         (10)         (10)         
      Hemorrhage                                       1 [2.0]                                3 [1.0]                   1 [1.0]     
      Inflammation, Chronic Active                                                                         1 [1.0]                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:22:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      10 NG/KG     30 NG/KG     100          175          300          
                                                                                             NG/KG        NG/KG        NG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:22:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   550          1000                                                             
                                                      NG/KG        NG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98                                                               
                                                                                                                                    
  Scheduled Sacrifice                                 16           16                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)                                                             
      Inflammation                                    10 [1.4]     10 [1.5]                                                         
      Mixed Cell Focus, Multiple                       1                                                                            
      Hepatocyte, Hypertrophy                         10 [1.4]     10 [1.7]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)                                                             
      Hypertrophy                                                   1 [1.0]                                                         
   Thyroid Gland                                      (5)          (10)                                                             
      Follicular Cell, Hypertrophy                     5 [1.4]      3 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)                                                             
      Atrophy                                          3 [2.3]      6 [3.3]                                                         
   Uterus                                                          (10)                                                             
      Metaplasia, Squamous                                          2 [1.0]                                                         
      Endometrium, Hyperplasia, Cystic                              1 [4.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/14/02    
Route: GAVAGE                                   TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                     Time: 15:22:01    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   550          1000                                                             
                                                      NG/KG        NG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                                          (10)                                                             
      Pigmentation                                                 10 [1.7]                                                         
   Thymus                                             (10)         (10)                                                             
      Atrophy                                                       5 [1.4]                                                         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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