National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6178

TDMS Study 96010-03 Pathology Tables

NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03
Route: DOSED WATER                                                                                                Time: 13:20:00

                                                          FINAL#1/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  7775-09-9

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3            3            6            5                                     
    Moribund Sacrifice                                10           11           11            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           34           32           40                                     
    Natural Death                                                                1            1                                     
    Moribund Sacrifice                                              2                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (49)         (45)         (49)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Epithelium, Cyst                                                                        1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                                         2 (4%)                                             
      Basophilic Focus                                42 (84%)     44 (88%)     41 (82%)     42 (84%)                               
      Cholangiofibrosis                                1 (2%)                    1 (2%)       3 (6%)                                
      Clear Cell Focus                                 6 (12%)     16 (32%)     18 (36%)     10 (20%)                               
      Congestion                                       6 (12%)      2 (4%)       2 (4%)       1 (2%)                                
      Degeneration, Cystic, Focal                      1 (2%)                    1 (2%)       3 (6%)                                
      Eosinophilic Focus                                            1 (2%)       1 (2%)       2 (4%)                                
      Fibrosis, Focal                                                                         1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       7 (14%)      4 (8%)       8 (16%)      3 (6%)                                
      Hyperplasia, Focal, Histiocytic                 20 (40%)     19 (38%)     16 (32%)     23 (46%)                               
      Hyperplasia, Focal, Regenerative                 1 (2%)                                 1 (2%)                                
      Hyperplasia, Regenerative                                                               2 (4%)                                
      Infarct, Multiple                                             1 (2%)                                                          
      Infiltration Cellular, Focal,                                                                                                 
        Polymorphonuclear                                                        1 (2%)                                             
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Infiltration Cellular, Mixed Cell               39 (78%)     38 (76%)     35 (70%)     41 (82%)                               
      Mixed Cell Focus                                12 (24%)      6 (12%)      7 (14%)      8 (16%)                               
      Thrombosis                                                    1 (2%)                                                          
      Bile Duct, Cyst                                               1 (2%)                                                          
      Bile Duct, Hyperplasia                          29 (58%)     24 (48%)     34 (68%)     26 (52%)                               
      Capsule, Cyst                                    1 (2%)                                                                       
      Hepatocyte, Karyomegaly                                       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Necrosis, Focal                                   2 (4%)                    1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic                                      2 (4%)                                             
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
        Diffuse                                        1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Hepatocyte, Vacuolization Cytoplasmic, Focal    17 (34%)     10 (20%)     10 (20%)     10 (20%)                               
      Hepatocyte, Periportal, Vacuolization                                                                                         
        Cytoplasmic                                                 2 (4%)                                                          
      Hepatocyte, Periportal, Centrilobular,                                                                                        
        Vacuolization Cytoplasmic                                                1 (2%)                                             
      Hepatocyte, Centrilobular, Necrosis              2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
        Cytoplasmic                                    5 (10%)      3 (6%)       8 (16%)      3 (6%)                                
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic                                                 2 (4%)                                                          
   Mesentery                                          (18)         (10)         (13)         (16)                                   
      Inflammation, Chronic, Focal                                  1 (10%)                                                         
      Fat, Necrosis                                    4 (22%)      2 (20%)      1 (8%)                                             
      Fat, Necrosis, Focal                            12 (67%)      5 (50%)      9 (69%)     13 (81%)                               
   Pancreas                                           (50)         (49)         (49)         (49)                                   
      Lipomatosis                                                                             1 (2%)                                
      Acinus, Atrophy, Diffuse                                                                1 (2%)                                
      Acinus, Atrophy, Focal                          15 (30%)      8 (16%)      9 (18%)     16 (33%)                               
      Duct, Cyst, Focal                                1 (2%)       2 (4%)       4 (8%)       1 (2%)                                
      Duct, Cyst, Focal, Multiple                     10 (20%)     14 (29%)     11 (22%)     18 (37%)                               
      Duct, Hyperplasia, Focal                                                                1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy, Focal                                   2 (4%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                                         1 (2%)       1 (2%)       1 (2%)                                
      Erosion                                                       1 (2%)                                                          
      Inflammation, Chronic                                         2 (4%)       1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Perforation                                                                1 (2%)                                             
      Ulcer                                            2 (4%)       7 (14%)                   1 (2%)                                
      Epithelium, Hyperplasia                          2 (4%)       4 (8%)       6 (12%)      1 (2%)                                
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
      Erosion                                          2 (4%)                    2 (4%)       2 (4%)                                
      Erosion, Focal                                   1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)                                                          
      Pigmentation, Focal                              1 (2%)                                                                       
      Ulcer                                                         1 (2%)                                                          
   Tooth                                                           (2)          (2)          (1)                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Malformation                                                               1 (50%)                                            
      Dentine, Malformation                                         1 (50%)                                                         
      Peridontal Tissue, Inflammation, Chronic                      1 (50%)      2 (100%)                                           
      Peridontal Tissue, Inflammation, Chronic,                                                                                     
         Focal                                                                                1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                       (1)                                    
      Thrombosis                                                    1 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   4 (8%)       2 (4%)                    2 (4%)                                
      Infiltration Cellular, Mixed Cell                             1 (2%)       1 (2%)       4 (8%)                                
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                2 (4%)       3 (6%)       5 (10%)      2 (4%)                                
      Angiectasis                                      2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Cytoplasmic Alteration, Focal                    1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
      Degeneration, Cystic, Focal                                   1 (2%)                    1 (2%)                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)                    2 (4%)                                
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)                                                          
      Vacuolization Cytoplasmic, Focal                 7 (14%)     13 (26%)      7 (14%)      8 (16%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Hyperplasia, Focal                               3 (6%)       4 (8%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Focal, Lymphoid                                                  1 (2%)                                
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Hyperplasia, Focal                                                         1 (2%)                                             
   Parathyroid Gland                                  (47)         (47)         (48)         (47)                                   
      Hyperplasia, Focal                                                         1 (2%)                                             
   Pituitary Gland                                    (49)         (49)         (50)         (50)                                   
      Angiectasis                                     10 (20%)      6 (12%)      2 (4%)      13 (26%)                               
      Pigmentation, Focal                              1 (2%)                                                                       
      Pars Distalis, Angiectasis                       1 (2%)       2 (4%)       2 (4%)                                             
      Pars Distalis, Cyst                              2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cytoplasmic Alteration, Focal     3 (6%)       1 (2%)       2 (4%)       3 (6%)                                
      Pars Distalis, Degeneration, Cystic, Focal      11 (22%)     14 (29%)     11 (22%)      3 (6%)                                
      Pars Distalis, Hemorrhage, Focal                 9 (18%)      6 (12%)     10 (20%)      2 (4%)                                
      Pars Distalis, Hyperplasia, Focal                7 (14%)      5 (10%)     10 (20%)      4 (8%)                                
      Pars Distalis, Infiltration Cellular, Focal                                1 (2%)                                             
      Pars Nervosa, Hyperplasia, Atypical, Focal                    1 (2%)                                                          
      Rathke's Cleft, Cyst                             1 (2%)       2 (4%)                                                          
      Rathke's Cleft, Hemorrhage                       1 (2%)       2 (4%)       2 (4%)       6 (12%)                               
      Rathke's Cleft, Hyperplasia, Cystic                                        1 (2%)                                             
   Thyroid Gland                                      (47)         (47)         (43)         (46)                                   
      Congestion                                                                              1 (2%)                                
      Ultimobranchial Cyst                             1 (2%)                    1 (2%)                                             
      C-Cell, Hyperplasia                             43 (91%)     45 (96%)     43 (100%)    44 (96%)                               
      Follicle, Mineralization, Focal                 25 (53%)     26 (55%)     40 (93%)     44 (96%)                               
      Follicular Cell, Hyperplasia, Cystic, Focal      1 (2%)                                                                       
      Follicular Cell, Hypertrophy                     3 (6%)       7 (15%)     27 (63%)     42 (91%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)          (4)          (6)                                    
      Mediastinum, Cyst                                                          1 (25%)                                            
      Mediastinum, Thrombosis                                                                 1 (17%)                               
      Oral, Foreign Body, Focal                                                               1 (17%)                               
      Oral, Necrosis, Focal                                                                   1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (49)                                   
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                             5 (10%)      2 (4%)       6 (12%)      1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Hyperplasia, Cystic                              1 (2%)       4 (8%)       3 (6%)       1 (2%)                                
      Hyperplasia, Cystic, Focal                                    1 (2%)                                                          
      Inflammation, Chronic                            6 (12%)      2 (4%)       1 (2%)       3 (6%)                                
      Duct, Inflammation, Chronic                      1 (2%)                                                                       
   Ovary                                              (50)         (50)         (49)         (50)                                   
      Cyst                                             5 (10%)      1 (2%)       1 (2%)       4 (8%)                                
      Corpus Luteum, Hyperplasia                                                              1 (2%)                                
      Interstitial Cell, Hyperplasia                                1 (2%)       1 (2%)                                             
      Periovarian Tissue, Cyst                         4 (8%)       4 (8%)       2 (4%)       1 (2%)                                
   Uterus                                             (50)         (50)         (49)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Hydrometra                                       1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Focal, Suppurative                                                        1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)                    1 (2%)                                
      Ulcer, Chronic Active                                                                   1 (2%)                                
      Endometrium, Hyperplasia, Cystic                16 (32%)      7 (14%)     16 (33%)     11 (22%)                               
   Vagina                                             (6)          (3)          (3)          (1)                                    
      Cyst                                             2 (33%)      1 (33%)      1 (33%)      1 (100%)                              
      Inflammation, Chronic                            1 (17%)                                                                      
      Inflammation, Suppurative                                     1 (33%)      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                      2 (4%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Focal, Histiocytic                                            2 (4%)       2 (4%)                                
      Myeloid Cell, Hyperplasia                        7 (14%)      3 (6%)       2 (4%)       6 (12%)                               
      Myeloid Cell, Erythroid Cell, Hyperplasia                     2 (4%)       2 (4%)       3 (6%)                                
   Lymph Node                                         (36)         (34)         (30)         (39)                                   
      Hyperplasia, Plasma Cell                         1 (3%)                                                                       
      Pigmentation                                                                            1 (3%)                                
      Deep Cervical, Hemorrhage                        1 (3%)                                                                       
      Deep Cervical, Hyperplasia, Lymphoid             1 (3%)                                                                       
      Deep Cervical, Hyperplasia, Plasma Cell                                                 1 (3%)                                
      Mediastinal, Angiectasis                                                   1 (3%)                                             
      Mediastinal, Congestion                          1 (3%)                                                                       
      Mediastinal, Ectasia                             2 (6%)       4 (12%)      2 (7%)       4 (10%)                               
      Mediastinal, Hemorrhage                          6 (17%)      6 (18%)      5 (17%)      3 (8%)                                
      Mediastinal, Hyperplasia, Histiocytic            1 (3%)       4 (12%)      2 (7%)       3 (8%)                                
      Mediastinal, Hyperplasia, Lymphoid               1 (3%)       2 (6%)       2 (7%)       3 (8%)                                
      Mediastinal, Hyperplasia, Plasma Cell                         1 (3%)                                                          
      Mediastinal, Infiltration Cellular, Mixed                                                                                     
        Cell                                                                     1 (3%)                                             
      Mediastinal, Pigmentation                                                  1 (3%)                                             
      Pancreatic, Angiectasis                                       1 (3%)                                                          
      Pancreatic, Ectasia                              1 (3%)                                 1 (3%)                                
      Pancreatic, Hemorrhage                           5 (14%)      3 (9%)                    5 (13%)                               
      Pancreatic, Hyperplasia, Histiocytic            31 (86%)     22 (65%)     15 (50%)     25 (64%)                               
      Pancreatic, Hyperplasia, Lymphoid                                          1 (3%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Pigmentation                         1 (3%)       7 (21%)      3 (10%)      6 (15%)                               
   Lymph Node, Mandibular                             (4)          (6)          (4)          (5)                                    
      Ectasia                                                       1 (17%)                                                         
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Focal, Histiocytic                                            1 (2%)                                             
      Hyperplasia, Histiocytic                         2 (4%)       4 (8%)                    4 (8%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                            1 (2%)                    1 (2%)                                
      Fibrosis, Focal                                               1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                16 (32%)     21 (42%)      8 (16%)     17 (34%)                               
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Hyperplasia, Focal, Histiocytic                  2 (4%)       4 (8%)       2 (4%)       5 (10%)                               
      Infarct                                                                                 1 (2%)                                
      Pigmentation, Focal                                                        1 (2%)                                             
      Red Pulp, Fibrosis, Diffuse                                                             1 (2%)                                
   Thymus                                             (49)         (48)         (48)         (48)                                   
      Angiectasis                                      2 (4%)       1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Hemorrhage                                       1 (2%)                    2 (4%)       1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Dilatation                                      37 (74%)     39 (78%)     34 (68%)     38 (76%)                               
      Ectasia                                          4 (8%)       1 (2%)       3 (6%)       2 (4%)                                
      Fibrosis                                         2 (4%)       1 (2%)       1 (2%)       4 (8%)                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hyperplasia                                      7 (14%)     11 (22%)     10 (20%)      9 (18%)                               
      Hyperplasia, Focal                               1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Ulcer                                                                                   1 (2%)                                
      Subcutaneous Tissue, Fibrosis, Focal             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Compression, Focal                               9 (18%)      9 (18%)     10 (20%)      9 (18%)                               
      Hemorrhage, Focal                                             4 (8%)       3 (6%)       2 (4%)                                
      Necrosis, Focal                                               1 (2%)                                                          
      Thalamus, Mineralization, Focal                  1 (2%)                                                                       
      Thalamus, Necrosis, Focal                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                                 2 (4%)       1 (2%)                                
      Hemorrhage, Focal                                1 (2%)                    1 (2%)       2 (4%)                                
      Hyperplasia, Focal, Histiocytic                  1 (2%)       1 (2%)                    2 (4%)                                
      Hyperplasia, Histiocytic                         4 (8%)       6 (12%)      5 (10%)      2 (4%)                                
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                2 (4%)       3 (6%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic, Focal                     2 (4%)                    4 (8%)       2 (4%)                                
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          4 (8%)       2 (4%)       3 (6%)       2 (4%)                                
      Interstitium, Edema                                                                     1 (2%)                                
      Mediastinum, Edema                                                         1 (2%)                                             
      Peribronchiolar, Hyperplasia, Lymphoid                                     1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 (2%)       2 (4%)                                                          
      Nasolacrimal Duct, Inflammation                               1 (2%)                    1 (2%)                                
      Respiratory Epithelium, Metaplasia, Focal,                                                                                    
         Squamous                                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (49)         (47)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
      Cataract                                         2 (4%)       3 (6%)       1 (2%)       2 (4%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Retinal Detachment                               1 (2%)                                                                       
      Bilateral, Atrophy                                                                      1 (2%)                                
      Cornea, Inflammation, Chronic                    1 (2%)       1 (2%)                                                          
      Cornea, Necrosis, Focal                          1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Retina, Degeneration                             1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Cystic, Focal                       1 (2%)                                                                       
      Hyperplasia, Focal                                                                      1 (2%)                                
      Hyperplasia, Focal, Histiocytic                  2 (4%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)       1 (2%)       2 (4%)                                
      Metaplasia, Focal, Squamous                                                1 (2%)                                             
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (47)         (47)                                   
      Atrophy, Diffuse                                              1 (2%)                                                          
      Atrophy, Focal                                   1 (2%)                                 2 (4%)                                
      Cyst                                                                       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infarct                                                       1 (2%)       1 (2%)                                             
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (4%)                                                          
      Inflammation, Chronic, Focal, Granulomatous                                             1 (2%)                                
      Nephropathy                                     43 (86%)     41 (84%)     37 (79%)     38 (81%)                               
      Pelvis, Inflammation, Chronic                                 1 (2%)                                                          
      Pelvis, Transitional Epithelium, Hyperplasia                  1 (2%)                                                          
      Renal Tubule, Accumulation, Hyaline Droplet      5 (10%)     12 (24%)     11 (23%)      5 (11%)                               
      Renal Tubule, Pigmentation                       2 (4%)       1 (2%)       4 (9%)       4 (9%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           13           11           14                                     
    Natural Death                                      3           10            8            8                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           27           31           28                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (47)         (44)         (49)                                   
      Edema                                                                                   2 (4%)                                
   Intestine Large, Rectum                            (48)         (47)         (47)         (50)                                   
      Congestion                                                                              1 (2%)                                
      Edema                                                                                   1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
   Intestine Large, Cecum                             (47)         (46)         (43)         (47)                                   
      Edema                                                         1 (2%)                    1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Duodenum                          (49)         (46)         (46)         (47)                                   
      Ulcer                                                         1 (2%)                                                          
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Intestine Small, Jejunum                           (47)         (46)         (42)         (44)                                   
      Epithelium, Necrosis                                                       1 (2%)                                             
   Intestine Small, Ileum                             (47)         (46)         (42)         (47)                                   
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (50)         (50)         (48)         (50)                                   
      Angiectasis, Focal                               2 (4%)       1 (2%)       1 (2%)       3 (6%)                                
      Basophilic Focus                                27 (54%)     30 (60%)     33 (69%)     29 (58%)                               
      Cholangiofibrosis                                2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Clear Cell Focus                                21 (42%)     18 (36%)     29 (60%)     15 (30%)                               
      Congestion                                                    2 (4%)                                                          
      Degeneration, Cystic, Focal                     13 (26%)      9 (18%)     12 (25%)     14 (28%)                               
      Eosinophilic Focus                               2 (4%)       3 (6%)                    2 (4%)                                
      Fibrosis, Focal                                               1 (2%)                    1 (2%)                                
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       6 (12%)      2 (4%)       3 (6%)       5 (10%)                               
      Hyperplasia, Focal, Histiocytic                  6 (12%)      2 (4%)       8 (17%)      5 (10%)                               
      Hyperplasia, Focal, Lymphoid                                               1 (2%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infarct                                          1 (2%)                                                                       
      Infiltration Cellular, Mixed Cell               36 (72%)     29 (58%)     33 (69%)     28 (56%)                               
      Mixed Cell Focus                                13 (26%)     11 (22%)      3 (6%)       8 (16%)                               
      Bile Duct, Hyperplasia                          48 (96%)     49 (98%)     46 (96%)     50 (100%)                              
      Centrilobular, Congestion                                     1 (2%)                                                          
      Hepatocyte, Necrosis, Focal                                   1 (2%)                    2 (4%)                                
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
        Diffuse                                        3 (6%)       3 (6%)                    4 (8%)                                
      Hepatocyte, Vacuolization Cytoplasmic, Focal    26 (52%)     15 (30%)     14 (29%)     18 (36%)                               
      Hepatocyte, Periportal, Necrosis                              1 (2%)                                                          
      Hepatocyte, Periportal, Vacuolization                                                                                         
        Cytoplasmic                                                 1 (2%)       1 (2%)                                             
      Hepatocyte, Centrilobular, Atrophy                                                      1 (2%)                                
      Hepatocyte, Centrilobular, Necrosis              1 (2%)       3 (6%)       6 (13%)      4 (8%)                                
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
        Cytoplasmic                                    4 (8%)       9 (18%)     12 (25%)     11 (22%)                               
      Hepatocyte, Midzonal, Necrosis                   1 (2%)                                                                       
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic                                    6 (12%)      1 (2%)                    1 (2%)                                
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic, Focal                                          1 (2%)                                                          
      Portal, Fibrosis                                              1 (2%)                                                          
      Portal, Hemorrhage                                            1 (2%)                                                          
   Mesentery                                          (19)         (20)         (19)         (23)                                   
      Angiectasis                                                   1 (5%)                                                          
      Hemorrhage                                       1 (5%)                    1 (5%)                                             
      Inflammation, Chronic                                                      1 (5%)                                             
      Inflammation, Chronic, Focal                                                            1 (4%)                                
      Fat, Necrosis                                    2 (11%)                   2 (11%)      2 (9%)                                
      Fat, Necrosis, Focal                            12 (63%)     10 (50%)     13 (68%)     14 (61%)                               
   Pancreas                                           (49)         (49)         (49)         (50)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Acinus, Atrophy, Diffuse                                                                1 (2%)                                
      Acinus, Atrophy, Focal                          23 (47%)     23 (47%)     27 (55%)     15 (30%)                               
      Acinus, Hyperplasia, Focal                       1 (2%)       1 (2%)                                                          
      Duct, Cyst, Focal                                                          1 (2%)       1 (2%)                                
      Duct, Cyst, Focal, Multiple                     15 (31%)     13 (27%)     18 (37%)     15 (30%)                               
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Hyperplasia, Focal, Histiocytic                                                         1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)       1 (2%)                    4 (8%)                                
      Erosion                                                                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                         4 (8%)                    1 (2%)                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Inflammation, Focal                                           1 (2%)       1 (2%)                                             
      Ulcer                                            1 (2%)       5 (10%)      2 (4%)       4 (8%)                                
      Epithelium, Cyst                                 1 (2%)                                                                       
      Epithelium, Hyperplasia                          2 (4%)       8 (16%)      1 (2%)       7 (14%)                               
      Epithelium, Hyperplasia, Focal                                             1 (2%)                                             
   Stomach, Glandular                                 (49)         (48)         (48)         (50)                                   
      Erosion                                          3 (6%)       2 (4%)       4 (8%)       4 (8%)                                
      Perforation                                                                             1 (2%)                                
      Pigmentation, Focal                                           1 (2%)       1 (2%)                                             
      Ulcer                                            1 (2%)                                 3 (6%)                                
      Epithelium, Hyperplasia, Focal                                1 (2%)                                                          
   Tongue                                             (1)          (1)          (1)          (1)                                    
      Epithelium, Hyperplasia                          1 (100%)                                                                     
   Tooth                                                           (1)          (1)                                                 
      Malformation                                                               1 (100%)                                           
      Peridontal Tissue, Hyperplasia, Squamous                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   6 (12%)      3 (6%)       7 (14%)     10 (20%)                               
      Infiltration Cellular, Mixed Cell                2 (4%)       1 (2%)                    2 (4%)                                
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Thrombosis                                       1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Artery, Inflammation, Chronic, Focal             1 (2%)                                                                       
      Endocardium, Valve, Inflammation, Chronic,                                                                                    
         Focal                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (49)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)       7 (14%)      4 (8%)       3 (6%)                                
      Atrophy                                                                    1 (2%)                                             
      Cytoplasmic Alteration, Focal                    3 (6%)       3 (6%)       2 (4%)       4 (8%)                                
      Degeneration, Cystic, Focal                                                2 (4%)                                             
      Hyperplasia, Diffuse                                                       1 (2%)                                             
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Necrosis, Focal                                                            1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse                            1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic, Focal                12 (24%)      8 (16%)      7 (14%)      6 (12%)                               
      Capsule, Fibrosis, Focal                                      1 (2%)                                                          
   Adrenal Medulla                                    (49)         (49)         (50)         (50)                                   
      Hyperplasia, Focal                               5 (10%)     12 (24%)      9 (18%)     13 (26%)                               
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Hyperplasia                                                   2 (4%)                                                          
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (49)         (50)         (47)         (49)                                   
      Hyperplasia, Focal                                                                      1 (2%)                                
   Pituitary Gland                                    (48)         (50)         (49)         (50)                                   
      Angiectasis                                      2 (4%)       4 (8%)       1 (2%)       3 (6%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Hemorrhage, Focal                                                                       1 (2%)                                
      Pars Distalis, Cyst                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Cytoplasmic Alteration, Focal     3 (6%)       7 (14%)      3 (6%)       8 (16%)                               
      Pars Distalis, Degeneration, Cystic, Focal       2 (4%)       2 (4%)                                                          
      Pars Distalis, Hemorrhage, Focal                 2 (4%)       2 (4%)       1 (2%)       3 (6%)                                
      Pars Distalis, Hyperplasia, Focal                4 (8%)       2 (4%)       3 (6%)       1 (2%)                                
      Pars Distalis, Pars Nervosa, Hemorrhage,                                                                                      
         Focal                                                                   1 (2%)                                             
      Pars Intermedia, Hemorrhage, Focal                                         1 (2%)                                             
      Rathke's Cleft, Cyst                                                                    1 (2%)                                
      Rathke's Cleft, Hemorrhage                       1 (2%)                    2 (4%)       2 (4%)                                
      Rathke's Cleft, Hyperplasia, Cystic                           1 (2%)                                                          
   Thyroid Gland                                      (47)         (44)         (43)         (47)                                   
      C-Cell, Hyperplasia                             45 (96%)     42 (95%)     41 (95%)     44 (94%)                               
      C-Cell, Hyperplasia, Focal                                                 1 (2%)                                             
      Follicle, Cyst                                   1 (2%)                    1 (2%)       2 (4%)                                
      Follicle, Degeneration, Cystic, Focal            2 (4%)                                                                       
      Follicle, Mineralization, Focal                 45 (96%)     43 (98%)     42 (98%)     42 (89%)                               
      Follicular Cell, Hypertrophy                     4 (9%)      13 (30%)     33 (77%)     40 (85%)                               
      Follicular Cell, Hypertrophy, Focal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)          (6)          (2)          (7)                                    
      Abdominal, Fibrosis                                                        1 (50%)                                            
      Mediastinum, Hemorrhage                                       1 (17%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                                1 (2%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)                    2 (4%)                                
   Penis                                                           (2)                                                              
      Thrombosis                                                    1 (50%)                                                         
   Preputial Gland                                    (48)         (49)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Cyst                                                          1 (2%)       1 (2%)                                             
      Degeneration, Cystic                                          2 (4%)       1 (2%)       2 (4%)                                
      Hyperplasia, Cystic                                           1 (2%)                    1 (2%)                                
      Inflammation, Chronic                           22 (46%)     12 (24%)     18 (36%)     20 (40%)                               
      Necrosis                                                                                1 (2%)                                
   Prostate                                           (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic                           21 (42%)     23 (47%)     29 (58%)     30 (60%)                               
      Mineralization, Focal                            3 (6%)       2 (4%)       3 (6%)       4 (8%)                                
      Epithelium, Hyperplasia, Focal                  11 (22%)      4 (8%)       2 (4%)      11 (22%)                               
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          4 (8%)      10 (20%)      9 (18%)      6 (12%)                               
      Bilateral, Atrophy                                            1 (2%)                                                          
      Germinal Epithelium, Atrophy                                                            1 (2%)                                
      Germinal Epithelium, Degeneration                1 (2%)                                                                       
      Interstitial Cell, Hyperplasia, Focal            1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (48)         (50)         (49)                                   
      Angiectasis                                                   1 (2%)                                                          
      Atrophy                                                                                 1 (2%)                                
      Fibrosis                                         2 (4%)                                                                       
      Hyperplasia                                     28 (58%)     35 (73%)     41 (82%)     40 (82%)                               
      Myeloid Cell, Erythroid Cell, Hyperplasia        2 (4%)                                                                       
   Lymph Node                                         (34)         (24)         (26)         (34)                                   
      Ectasia                                          1 (3%)                                                                       
      Hemorrhage                                                                              1 (3%)                                
      Deep Cervical, Hemorrhage                                                  1 (4%)                                             
      Deep Cervical, Hyperplasia, Plasma Cell          1 (3%)                                                                       
      Mediastinal, Angiectasis                                                   1 (4%)                                             
      Mediastinal, Ectasia                             5 (15%)      7 (29%)      5 (19%)      3 (9%)                                
      Mediastinal, Hemorrhage                          3 (9%)       2 (8%)       2 (8%)       1 (3%)                                
      Mediastinal, Hyperplasia, Histiocytic                         3 (13%)      2 (8%)       1 (3%)                                
      Mediastinal, Hyperplasia, Lymphoid               1 (3%)                    1 (4%)       3 (9%)                                
      Mediastinal, Hyperplasia, Plasma Cell            1 (3%)                    2 (8%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Infiltration Cellular,                                                                                           
        Polymorphonuclear                                           1 (4%)                                                          
      Mediastinal, Inflammation, Chronic Active                                               1 (3%)                                
      Mediastinal, Inflammation, Suppurative                        1 (4%)                                                          
      Pancreatic, Angiectasis                          2 (6%)                                                                       
      Pancreatic, Ectasia                              3 (9%)       3 (13%)      3 (12%)      6 (18%)                               
      Pancreatic, Hemorrhage                           5 (15%)      3 (13%)      1 (4%)       1 (3%)                                
      Pancreatic, Hyperplasia, Histiocytic             8 (24%)      5 (21%)      9 (35%)      6 (18%)                               
      Pancreatic, Hyperplasia, Lymphoid                1 (3%)       1 (4%)                                                          
      Pancreatic, Pigmentation                         1 (3%)       1 (4%)       1 (4%)                                             
      Renal, Hemorrhage                                                          1 (4%)                                             
      Renal, Hyperplasia, Focal, Histiocytic                        1 (4%)                                                          
      Renal, Hyperplasia, Lymphoid                                  1 (4%)                                                          
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (50)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Ectasia                                          1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Hemorrhage                                                    2 (4%)       3 (6%)                                             
      Hyperplasia, Focal, Histiocytic                  1 (2%)                                                                       
      Hyperplasia, Histiocytic                         3 (6%)       3 (6%)                    1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                    1 (2%)                                
   Spleen                                             (48)         (49)         (49)         (50)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Angiectasis, Focal                                            2 (4%)       1 (2%)       3 (6%)                                
      Atrophy                                                                                 1 (2%)                                
      Congestion                                       1 (2%)                                 1 (2%)                                
      Fibrosis, Focal                                               2 (4%)       2 (4%)       4 (8%)                                
      Hematopoietic Cell Proliferation                 2 (4%)       6 (12%)      4 (8%)      11 (22%)                               
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia, Focal, Histiocytic                  1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Infarct, Multiple                                                                       1 (2%)                                
      Metaplasia, Focal, Lipocyte                                                1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Pigmentation                                                                            1 (2%)                                
      Pigmentation, Focal                                                        1 (2%)                                             
      Capsule, Accessory Spleen, Focal                 1 (2%)                                                                       
      Capsule, Fibrosis, Focal                                                                1 (2%)                                
      Lymphoid Follicle, Atrophy                                    1 (2%)                                                          
   Thymus                                             (48)         (48)         (49)         (47)                                   
      Angiectasis                                                                1 (2%)                                             
      Cyst                                                          1 (2%)                                                          
      Hemorrhage                                       1 (2%)       2 (4%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                                      2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   15                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (43)         (47)         (44)                                   
      Cyst                                                                                    1 (2%)                                
      Dilatation                                       7 (16%)      7 (16%)      7 (15%)      2 (5%)                                
      Hyperplasia                                                   1 (2%)       2 (4%)       2 (5%)                                
      Inflammation, Chronic, Focal                     1 (2%)                                 1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        3 (6%)       1 (2%)       3 (6%)       1 (2%)                                
      Fibrosis, Focal                                               2 (4%)                                                          
      Hyperkeratosis, Focal                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                                  2 (4%)                                                          
      Ulcer                                                         1 (2%)                                                          
      Artery, Subcutaneous Tissue, Thrombosis                       1 (2%)                                                          
      Epidermis, Hyperplasia, Focal                    1 (2%)                                                                       
      Lip, Inflammation, Chronic, Focal                             1 (2%)                                                          
      Subcutaneous Tissue, Cyst                                     1 (2%)                                                          
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
        Inclusion                                                                1 (2%)                                             
      Subcutaneous Tissue, Hyperplasia, Focal,                                                                                      
         Histiocytic                                                                          1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
         Focal                                                      1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
         Focal, Suppurative                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Cranium, Hyperostosis                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression, Focal                               6 (12%)      6 (12%)      7 (14%)      6 (12%)                               
      Hemorrhage, Focal                                2 (4%)       2 (4%)       4 (8%)       6 (12%)                               
      Cerebrum, Ventricle, Hydrocephalus                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   16                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       2 (4%)       1 (2%)       3 (6%)                                             
      Foreign Body, Focal                              1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hemorrhage, Focal                                3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Hyperplasia, Focal, Histiocytic                               1 (2%)       1 (2%)                                             
      Hyperplasia, Histiocytic                         2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Mixed Cell                1 (2%)       3 (6%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic, Focal                     5 (10%)      2 (4%)       3 (6%)       3 (6%)                                
      Inflammation, Focal, Suppurative                              1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          8 (16%)      5 (10%)      3 (6%)       4 (8%)                                
      Alveolar Epithelium, Metaplasia, Squamous                     1 (2%)                                                          
      Alveolus, Edema, Focal                                                     1 (2%)                                             
      Alveolus, Hyperplasia, Focal, Histiocytic        1 (2%)                                                                       
      Interstitium, Edema                                           1 (2%)                    1 (2%)                                
      Mediastinum, Edema                                            1 (2%)       1 (2%)                                             
   Nose                                               (49)         (49)         (49)         (50)                                   
      Foreign Body                                                  1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)       1 (2%)       6 (12%)      1 (2%)                                
      Nasolacrimal Duct, Inflammation                  1 (2%)       3 (6%)                    1 (2%)                                
      Olfactory Epithelium, Hyperplasia, Focal                                   1 (2%)                                             
      Respiratory Epithelium, Hyperplasia, Focal                                 1 (2%)                                             
   Trachea                                            (50)         (49)         (50)         (50)                                   
      Peritracheal Tissue, Edema                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (48)         (46)         (50)                                   
      Atrophy                                                                                 2 (4%)                                
      Cataract                                                      2 (4%)       1 (2%)       2 (4%)                                
      Exudate                                                       1 (2%)                                                          
      Cornea, Inflammation, Chronic                                              1 (2%)                                             
      Cornea, Retrobulbar, Inflammation, Chronic                                                                                    
        Active                                                                                1 (2%)                                
      Retina, Degeneration                                          2 (4%)       1 (2%)       2 (4%)                                
   Harderian Gland                                    (49)         (49)         (49)         (50)                                   
      Fibrosis, Focal                                                                         1 (2%)                                
      Hyperplasia, Focal, Histiocytic                               1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic, Focal                                  1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active, Diffuse                                                   1 (2%)                                
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   17                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (47)         (46)         (49)         (49)                                   
      Cyst                                                                       1 (2%)                                             
      Cyst, Multiple                                                1 (2%)                                                          
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                                                    1 (2%)                                             
      Infarct, Multiple                                1 (2%)       1 (2%)                                                          
      Metaplasia, Focal, Lipocyte                                   1 (2%)                                                          
      Nephropathy                                     45 (96%)     44 (96%)     48 (98%)     47 (96%)                               
      Cortex, Medulla, Atrophy                                      1 (2%)                                                          
      Pelvis, Infiltration Cellular, Mixed Cell                                               1 (2%)                                
      Pelvis, Transitional Epithelium, Hyperplasia                  1 (2%)       1 (2%)                                             
      Renal Tubule, Accumulation, Hyaline Droplet                   1 (2%)       4 (8%)       2 (4%)                                
      Renal Tubule, Hyperplasia, Focal                              1 (2%)                                                          
      Renal Tubule, Pigmentation                       4 (9%)       4 (9%)       1 (2%)       4 (8%)                                
   Urinary Bladder                                    (48)         (49)         (47)         (50)                                   
      Calculus Micro Observation Only                               1 (2%)                                                          
      Edema                                                                                   2 (4%)                                
      Hemorrhage                                                                 2 (4%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Serosa, Inflammation, Focal                                                             1 (2%)                                
      Transitional Epithelium, Hyperplasia, Diffuse                 1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   18                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 133482-133482/133482


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.