Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/6178

TDMS Study 96010-03 Pathology Tables

NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03
Route: DOSED WATER                                                                                                Time: 13:20:00

                                                          FINAL#1/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  7775-09-9

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3            3            6            5                                     
    Moribund Sacrifice                                10           11           11            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           34           32           40                                     
    Natural Death                                                                1            1                                     
    Moribund Sacrifice                                              2                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (49)         (45)         (49)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Epithelium, Cyst                                                                        1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                                         2 (4%)                                             
      Basophilic Focus                                42 (84%)     44 (88%)     41 (82%)     42 (84%)                               
      Cholangiofibrosis                                1 (2%)                    1 (2%)       3 (6%)                                
      Clear Cell Focus                                 6 (12%)     16 (32%)     18 (36%)     10 (20%)                               
      Congestion                                       6 (12%)      2 (4%)       2 (4%)       1 (2%)                                
      Degeneration, Cystic, Focal                      1 (2%)                    1 (2%)       3 (6%)                                
      Eosinophilic Focus                                            1 (2%)       1 (2%)       2 (4%)                                
      Fibrosis, Focal                                                                         1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       7 (14%)      4 (8%)       8 (16%)      3 (6%)                                
      Hyperplasia, Focal, Histiocytic                 20 (40%)     19 (38%)     16 (32%)     23 (46%)                               
      Hyperplasia, Focal, Regenerative                 1 (2%)                                 1 (2%)                                
      Hyperplasia, Regenerative                                                               2 (4%)                                
      Infarct, Multiple                                             1 (2%)                                                          
      Infiltration Cellular, Focal,                                                                                                 
        Polymorphonuclear                                                        1 (2%)                                             
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Infiltration Cellular, Mixed Cell               39 (78%)     38 (76%)     35 (70%)     41 (82%)                               
      Mixed Cell Focus                                12 (24%)      6 (12%)      7 (14%)      8 (16%)                               
      Thrombosis                                                    1 (2%)                                                          
      Bile Duct, Cyst                                               1 (2%)                                                          
      Bile Duct, Hyperplasia                          29 (58%)     24 (48%)     34 (68%)     26 (52%)                               
      Capsule, Cyst                                    1 (2%)                                                                       
      Hepatocyte, Karyomegaly                                       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Necrosis, Focal                                   2 (4%)                    1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic                                      2 (4%)                                             
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
        Diffuse                                        1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Hepatocyte, Vacuolization Cytoplasmic, Focal    17 (34%)     10 (20%)     10 (20%)     10 (20%)                               
      Hepatocyte, Periportal, Vacuolization                                                                                         
        Cytoplasmic                                                 2 (4%)                                                          
      Hepatocyte, Periportal, Centrilobular,                                                                                        
        Vacuolization Cytoplasmic                                                1 (2%)                                             
      Hepatocyte, Centrilobular, Necrosis              2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
        Cytoplasmic                                    5 (10%)      3 (6%)       8 (16%)      3 (6%)                                
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic                                                 2 (4%)                                                          
   Mesentery                                          (18)         (10)         (13)         (16)                                   
      Inflammation, Chronic, Focal                                  1 (10%)                                                         
      Fat, Necrosis                                    4 (22%)      2 (20%)      1 (8%)                                             
      Fat, Necrosis, Focal                            12 (67%)      5 (50%)      9 (69%)     13 (81%)                               
   Pancreas                                           (50)         (49)         (49)         (49)                                   
      Lipomatosis                                                                             1 (2%)                                
      Acinus, Atrophy, Diffuse                                                                1 (2%)                                
      Acinus, Atrophy, Focal                          15 (30%)      8 (16%)      9 (18%)     16 (33%)                               
      Duct, Cyst, Focal                                1 (2%)       2 (4%)       4 (8%)       1 (2%)                                
      Duct, Cyst, Focal, Multiple                     10 (20%)     14 (29%)     11 (22%)     18 (37%)                               
      Duct, Hyperplasia, Focal                                                                1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy, Focal                                   2 (4%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                                         1 (2%)       1 (2%)       1 (2%)                                
      Erosion                                                       1 (2%)                                                          
      Inflammation, Chronic                                         2 (4%)       1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Perforation                                                                1 (2%)                                             
      Ulcer                                            2 (4%)       7 (14%)                   1 (2%)                                
      Epithelium, Hyperplasia                          2 (4%)       4 (8%)       6 (12%)      1 (2%)                                
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
      Erosion                                          2 (4%)                    2 (4%)       2 (4%)                                
      Erosion, Focal                                   1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)                                                          
      Pigmentation, Focal                              1 (2%)                                                                       
      Ulcer                                                         1 (2%)                                                          
   Tooth                                                           (2)          (2)          (1)                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Malformation                                                               1 (50%)                                            
      Dentine, Malformation                                         1 (50%)                                                         
      Peridontal Tissue, Inflammation, Chronic                      1 (50%)      2 (100%)                                           
      Peridontal Tissue, Inflammation, Chronic,                                                                                     
         Focal                                                                                1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                       (1)                                    
      Thrombosis                                                    1 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   4 (8%)       2 (4%)                    2 (4%)                                
      Infiltration Cellular, Mixed Cell                             1 (2%)       1 (2%)       4 (8%)                                
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                2 (4%)       3 (6%)       5 (10%)      2 (4%)                                
      Angiectasis                                      2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Cytoplasmic Alteration, Focal                    1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
      Degeneration, Cystic, Focal                                   1 (2%)                    1 (2%)                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)                    2 (4%)                                
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)                                                          
      Vacuolization Cytoplasmic, Focal                 7 (14%)     13 (26%)      7 (14%)      8 (16%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Hyperplasia, Focal                               3 (6%)       4 (8%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Focal, Lymphoid                                                  1 (2%)                                
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Hyperplasia, Focal                                                         1 (2%)                                             
   Parathyroid Gland                                  (47)         (47)         (48)         (47)                                   
      Hyperplasia, Focal                                                         1 (2%)                                             
   Pituitary Gland                                    (49)         (49)         (50)         (50)                                   
      Angiectasis                                     10 (20%)      6 (12%)      2 (4%)      13 (26%)                               
      Pigmentation, Focal                              1 (2%)                                                                       
      Pars Distalis, Angiectasis                       1 (2%)       2 (4%)       2 (4%)                                             
      Pars Distalis, Cyst                              2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cytoplasmic Alteration, Focal     3 (6%)       1 (2%)       2 (4%)       3 (6%)                                
      Pars Distalis, Degeneration, Cystic, Focal      11 (22%)     14 (29%)     11 (22%)      3 (6%)                                
      Pars Distalis, Hemorrhage, Focal                 9 (18%)      6 (12%)     10 (20%)      2 (4%)                                
      Pars Distalis, Hyperplasia, Focal                7 (14%)      5 (10%)     10 (20%)      4 (8%)                                
      Pars Distalis, Infiltration Cellular, Focal                                1 (2%)                                             
      Pars Nervosa, Hyperplasia, Atypical, Focal                    1 (2%)                                                          
      Rathke's Cleft, Cyst                             1 (2%)       2 (4%)                                                          
      Rathke's Cleft, Hemorrhage                       1 (2%)       2 (4%)       2 (4%)       6 (12%)                               
      Rathke's Cleft, Hyperplasia, Cystic                                        1 (2%)                                             
   Thyroid Gland                                      (47)         (47)         (43)         (46)                                   
      Congestion                                                                              1 (2%)                                
      Ultimobranchial Cyst                             1 (2%)                    1 (2%)                                             
      C-Cell, Hyperplasia                             43 (91%)     45 (96%)     43 (100%)    44 (96%)                               
      Follicle, Mineralization, Focal                 25 (53%)     26 (55%)     40 (93%)     44 (96%)                               
      Follicular Cell, Hyperplasia, Cystic, Focal      1 (2%)                                                                       
      Follicular Cell, Hypertrophy                     3 (6%)       7 (15%)     27 (63%)     42 (91%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)          (4)          (6)                                    
      Mediastinum, Cyst                                                          1 (25%)                                            
      Mediastinum, Thrombosis                                                                 1 (17%)                               
      Oral, Foreign Body, Focal                                                               1 (17%)                               
      Oral, Necrosis, Focal                                                                   1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (49)                                   
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                             5 (10%)      2 (4%)       6 (12%)      1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Hyperplasia, Cystic                              1 (2%)       4 (8%)       3 (6%)       1 (2%)                                
      Hyperplasia, Cystic, Focal                                    1 (2%)                                                          
      Inflammation, Chronic                            6 (12%)      2 (4%)       1 (2%)       3 (6%)                                
      Duct, Inflammation, Chronic                      1 (2%)                                                                       
   Ovary                                              (50)         (50)         (49)         (50)                                   
      Cyst                                             5 (10%)      1 (2%)       1 (2%)       4 (8%)                                
      Corpus Luteum, Hyperplasia                                                              1 (2%)                                
      Interstitial Cell, Hyperplasia                                1 (2%)       1 (2%)                                             
      Periovarian Tissue, Cyst                         4 (8%)       4 (8%)       2 (4%)       1 (2%)                                
   Uterus                                             (50)         (50)         (49)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Hydrometra                                       1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Focal, Suppurative                                                        1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)                    1 (2%)                                
      Ulcer, Chronic Active                                                                   1 (2%)                                
      Endometrium, Hyperplasia, Cystic                16 (32%)      7 (14%)     16 (33%)     11 (22%)                               
   Vagina                                             (6)          (3)          (3)          (1)                                    
      Cyst                                             2 (33%)      1 (33%)      1 (33%)      1 (100%)                              
      Inflammation, Chronic                            1 (17%)                                                                      
      Inflammation, Suppurative                                     1 (33%)      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                      2 (4%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Focal, Histiocytic                                            2 (4%)       2 (4%)                                
      Myeloid Cell, Hyperplasia                        7 (14%)      3 (6%)       2 (4%)       6 (12%)                               
      Myeloid Cell, Erythroid Cell, Hyperplasia                     2 (4%)       2 (4%)       3 (6%)                                
   Lymph Node                                         (36)         (34)         (30)         (39)                                   
      Hyperplasia, Plasma Cell                         1 (3%)                                                                       
      Pigmentation                                                                            1 (3%)                                
      Deep Cervical, Hemorrhage                        1 (3%)                                                                       
      Deep Cervical, Hyperplasia, Lymphoid             1 (3%)                                                                       
      Deep Cervical, Hyperplasia, Plasma Cell                                                 1 (3%)                                
      Mediastinal, Angiectasis                                                   1 (3%)                                             
      Mediastinal, Congestion                          1 (3%)                                                                       
      Mediastinal, Ectasia                             2 (6%)       4 (12%)      2 (7%)       4 (10%)                               
      Mediastinal, Hemorrhage                          6 (17%)      6 (18%)      5 (17%)      3 (8%)                                
      Mediastinal, Hyperplasia, Histiocytic            1 (3%)       4 (12%)      2 (7%)       3 (8%)                                
      Mediastinal, Hyperplasia, Lymphoid               1 (3%)       2 (6%)       2 (7%)       3 (8%)                                
      Mediastinal, Hyperplasia, Plasma Cell                         1 (3%)                                                          
      Mediastinal, Infiltration Cellular, Mixed                                                                                     
        Cell                                                                     1 (3%)                                             
      Mediastinal, Pigmentation                                                  1 (3%)                                             
      Pancreatic, Angiectasis                                       1 (3%)                                                          
      Pancreatic, Ectasia                              1 (3%)                                 1 (3%)                                
      Pancreatic, Hemorrhage                           5 (14%)      3 (9%)                    5 (13%)                               
      Pancreatic, Hyperplasia, Histiocytic            31 (86%)     22 (65%)     15 (50%)     25 (64%)                               
      Pancreatic, Hyperplasia, Lymphoid                                          1 (3%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Pigmentation                         1 (3%)       7 (21%)      3 (10%)      6 (15%)                               
   Lymph Node, Mandibular                             (4)          (6)          (4)          (5)                                    
      Ectasia                                                       1 (17%)                                                         
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Focal, Histiocytic                                            1 (2%)                                             
      Hyperplasia, Histiocytic                         2 (4%)       4 (8%)                    4 (8%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                            1 (2%)                    1 (2%)                                
      Fibrosis, Focal                                               1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                16 (32%)     21 (42%)      8 (16%)     17 (34%)                               
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Hyperplasia, Focal, Histiocytic                  2 (4%)       4 (8%)       2 (4%)       5 (10%)                               
      Infarct                                                                                 1 (2%)                                
      Pigmentation, Focal                                                        1 (2%)                                             
      Red Pulp, Fibrosis, Diffuse                                                             1 (2%)                                
   Thymus                                             (49)         (48)         (48)         (48)                                   
      Angiectasis                                      2 (4%)       1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Hemorrhage                                       1 (2%)                    2 (4%)       1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Dilatation                                      37 (74%)     39 (78%)     34 (68%)     38 (76%)                               
      Ectasia                                          4 (8%)       1 (2%)       3 (6%)       2 (4%)                                
      Fibrosis                                         2 (4%)       1 (2%)       1 (2%)       4 (8%)                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hyperplasia                                      7 (14%)     11 (22%)     10 (20%)      9 (18%)                               
      Hyperplasia, Focal                               1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Ulcer                                                                                   1 (2%)                                
      Subcutaneous Tissue, Fibrosis, Focal             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Compression, Focal                               9 (18%)      9 (18%)     10 (20%)      9 (18%)                               
      Hemorrhage, Focal                                             4 (8%)       3 (6%)       2 (4%)                                
      Necrosis, Focal                                               1 (2%)                                                          
      Thalamus, Mineralization, Focal                  1 (2%)                                                                       
      Thalamus, Necrosis, Focal                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                                 2 (4%)       1 (2%)                                
      Hemorrhage, Focal                                1 (2%)                    1 (2%)       2 (4%)                                
      Hyperplasia, Focal, Histiocytic                  1 (2%)       1 (2%)                    2 (4%)                                
      Hyperplasia, Histiocytic                         4 (8%)       6 (12%)      5 (10%)      2 (4%)                                
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                2 (4%)       3 (6%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic, Focal                     2 (4%)                    4 (8%)       2 (4%)                                
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          4 (8%)       2 (4%)       3 (6%)       2 (4%)                                
      Interstitium, Edema                                                                     1 (2%)                                
      Mediastinum, Edema                                                         1 (2%)                                             
      Peribronchiolar, Hyperplasia, Lymphoid                                     1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 (2%)       2 (4%)                                                          
      Nasolacrimal Duct, Inflammation                               1 (2%)                    1 (2%)                                
      Respiratory Epithelium, Metaplasia, Focal,                                                                                    
         Squamous                                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (49)         (47)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
      Cataract                                         2 (4%)       3 (6%)       1 (2%)       2 (4%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Retinal Detachment                               1 (2%)                                                                       
      Bilateral, Atrophy                                                                      1 (2%)                                
      Cornea, Inflammation, Chronic                    1 (2%)       1 (2%)                                                          
      Cornea, Necrosis, Focal                          1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Retina, Degeneration                             1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Cystic, Focal                       1 (2%)                                                                       
      Hyperplasia, Focal                                                                      1 (2%)                                
      Hyperplasia, Focal, Histiocytic                  2 (4%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)       1 (2%)       2 (4%)                                
      Metaplasia, Focal, Squamous                                                1 (2%)                                             
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (47)         (47)                                   
      Atrophy, Diffuse                                              1 (2%)                                                          
      Atrophy, Focal                                   1 (2%)                                 2 (4%)                                
      Cyst                                                                       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infarct                                                       1 (2%)       1 (2%)                                             
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (4%)                                                          
      Inflammation, Chronic, Focal, Granulomatous                                             1 (2%)                                
      Nephropathy                                     43 (86%)     41 (84%)     37 (79%)     38 (81%)                               
      Pelvis, Inflammation, Chronic                                 1 (2%)                                                          
      Pelvis, Transitional Epithelium, Hyperplasia                  1 (2%)                                                          
      Renal Tubule, Accumulation, Hyaline Droplet      5 (10%)     12 (24%)     11 (23%)      5 (11%)                               
      Renal Tubule, Pigmentation                       2 (4%)       1 (2%)       4 (9%)       4 (9%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           13           11           14                                     
    Natural Death                                      3           10            8            8                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           27           31           28                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (47)         (44)         (49)                                   
      Edema                                                                                   2 (4%)                                
   Intestine Large, Rectum                            (48)         (47)         (47)         (50)                                   
      Congestion                                                                              1 (2%)                                
      Edema                                                                                   1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
   Intestine Large, Cecum                             (47)         (46)         (43)         (47)                                   
      Edema                                                         1 (2%)                    1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Duodenum                          (49)         (46)         (46)         (47)                                   
      Ulcer                                                         1 (2%)                                                          
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Intestine Small, Jejunum                           (47)         (46)         (42)         (44)                                   
      Epithelium, Necrosis                                                       1 (2%)                                             
   Intestine Small, Ileum                             (47)         (46)         (42)         (47)                                   
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (50)         (50)         (48)         (50)                                   
      Angiectasis, Focal                               2 (4%)       1 (2%)       1 (2%)       3 (6%)                                
      Basophilic Focus                                27 (54%)     30 (60%)     33 (69%)     29 (58%)                               
      Cholangiofibrosis                                2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Clear Cell Focus                                21 (42%)     18 (36%)     29 (60%)     15 (30%)                               
      Congestion                                                    2 (4%)                                                          
      Degeneration, Cystic, Focal                     13 (26%)      9 (18%)     12 (25%)     14 (28%)                               
      Eosinophilic Focus                               2 (4%)       3 (6%)                    2 (4%)                                
      Fibrosis, Focal                                               1 (2%)                    1 (2%)                                
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       6 (12%)      2 (4%)       3 (6%)       5 (10%)                               
      Hyperplasia, Focal, Histiocytic                  6 (12%)      2 (4%)       8 (17%)      5 (10%)                               
      Hyperplasia, Focal, Lymphoid                                               1 (2%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infarct                                          1 (2%)                                                                       
      Infiltration Cellular, Mixed Cell               36 (72%)     29 (58%)     33 (69%)     28 (56%)                               
      Mixed Cell Focus                                13 (26%)     11 (22%)      3 (6%)       8 (16%)                               
      Bile Duct, Hyperplasia                          48 (96%)     49 (98%)     46 (96%)     50 (100%)                              
      Centrilobular, Congestion                                     1 (2%)                                                          
      Hepatocyte, Necrosis, Focal                                   1 (2%)                    2 (4%)                                
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
        Diffuse                                        3 (6%)       3 (6%)                    4 (8%)                                
      Hepatocyte, Vacuolization Cytoplasmic, Focal    26 (52%)     15 (30%)     14 (29%)     18 (36%)                               
      Hepatocyte, Periportal, Necrosis                              1 (2%)                                                          
      Hepatocyte, Periportal, Vacuolization                                                                                         
        Cytoplasmic                                                 1 (2%)       1 (2%)                                             
      Hepatocyte, Centrilobular, Atrophy                                                      1 (2%)                                
      Hepatocyte, Centrilobular, Necrosis              1 (2%)       3 (6%)       6 (13%)      4 (8%)                                
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
        Cytoplasmic                                    4 (8%)       9 (18%)     12 (25%)     11 (22%)                               
      Hepatocyte, Midzonal, Necrosis                   1 (2%)                                                                       
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic                                    6 (12%)      1 (2%)                    1 (2%)                                
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic, Focal                                          1 (2%)                                                          
      Portal, Fibrosis                                              1 (2%)                                                          
      Portal, Hemorrhage                                            1 (2%)                                                          
   Mesentery                                          (19)         (20)         (19)         (23)                                   
      Angiectasis                                                   1 (5%)                                                          
      Hemorrhage                                       1 (5%)                    1 (5%)                                             
      Inflammation, Chronic                                                      1 (5%)                                             
      Inflammation, Chronic, Focal                                                            1 (4%)                                
      Fat, Necrosis                                    2 (11%)                   2 (11%)      2 (9%)                                
      Fat, Necrosis, Focal                            12 (63%)     10 (50%)     13 (68%)     14 (61%)                               
   Pancreas                                           (49)         (49)         (49)         (50)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Acinus, Atrophy, Diffuse                                                                1 (2%)                                
      Acinus, Atrophy, Focal                          23 (47%)     23 (47%)     27 (55%)     15 (30%)                               
      Acinus, Hyperplasia, Focal                       1 (2%)       1 (2%)                                                          
      Duct, Cyst, Focal                                                          1 (2%)       1 (2%)                                
      Duct, Cyst, Focal, Multiple                     15 (31%)     13 (27%)     18 (37%)     15 (30%)                               
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Hyperplasia, Focal, Histiocytic                                                         1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)       1 (2%)                    4 (8%)                                
      Erosion                                                                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                         4 (8%)                    1 (2%)                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Inflammation, Focal                                           1 (2%)       1 (2%)                                             
      Ulcer                                            1 (2%)       5 (10%)      2 (4%)       4 (8%)                                
      Epithelium, Cyst                                 1 (2%)                                                                       
      Epithelium, Hyperplasia                          2 (4%)       8 (16%)      1 (2%)       7 (14%)                               
      Epithelium, Hyperplasia, Focal                                             1 (2%)                                             
   Stomach, Glandular                                 (49)         (48)         (48)         (50)                                   
      Erosion                                          3 (6%)       2 (4%)       4 (8%)       4 (8%)                                
      Perforation                                                                             1 (2%)                                
      Pigmentation, Focal                                           1 (2%)       1 (2%)                                             
      Ulcer                                            1 (2%)                                 3 (6%)                                
      Epithelium, Hyperplasia, Focal                                1 (2%)                                                          
   Tongue                                             (1)          (1)          (1)          (1)                                    
      Epithelium, Hyperplasia                          1 (100%)                                                                     
   Tooth                                                           (1)          (1)                                                 
      Malformation                                                               1 (100%)                                           
      Peridontal Tissue, Hyperplasia, Squamous                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   6 (12%)      3 (6%)       7 (14%)     10 (20%)                               
      Infiltration Cellular, Mixed Cell                2 (4%)       1 (2%)                    2 (4%)                                
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Thrombosis                                       1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Artery, Inflammation, Chronic, Focal             1 (2%)                                                                       
      Endocardium, Valve, Inflammation, Chronic,                                                                                    
         Focal                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (49)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)       7 (14%)      4 (8%)       3 (6%)                                
      Atrophy                                                                    1 (2%)                                             
      Cytoplasmic Alteration, Focal                    3 (6%)       3 (6%)       2 (4%)       4 (8%)                                
      Degeneration, Cystic, Focal                                                2 (4%)                                             
      Hyperplasia, Diffuse                                                       1 (2%)                                             
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Necrosis, Focal                                                            1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse                            1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic, Focal                12 (24%)      8 (16%)      7 (14%)      6 (12%)                               
      Capsule, Fibrosis, Focal                                      1 (2%)                                                          
   Adrenal Medulla                                    (49)         (49)         (50)         (50)                                   
      Hyperplasia, Focal                               5 (10%)     12 (24%)      9 (18%)     13 (26%)                               
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Hyperplasia                                                   2 (4%)                                                          
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (49)         (50)         (47)         (49)                                   
      Hyperplasia, Focal                                                                      1 (2%)                                
   Pituitary Gland                                    (48)         (50)         (49)         (50)                                   
      Angiectasis                                      2 (4%)       4 (8%)       1 (2%)       3 (6%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Hemorrhage, Focal                                                                       1 (2%)                                
      Pars Distalis, Cyst                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Cytoplasmic Alteration, Focal     3 (6%)       7 (14%)      3 (6%)       8 (16%)                               
      Pars Distalis, Degeneration, Cystic, Focal       2 (4%)       2 (4%)                                                          
      Pars Distalis, Hemorrhage, Focal                 2 (4%)       2 (4%)       1 (2%)       3 (6%)                                
      Pars Distalis, Hyperplasia, Focal                4 (8%)       2 (4%)       3 (6%)       1 (2%)                                
      Pars Distalis, Pars Nervosa, Hemorrhage,                                                                                      
         Focal                                                                   1 (2%)                                             
      Pars Intermedia, Hemorrhage, Focal                                         1 (2%)                                             
      Rathke's Cleft, Cyst                                                                    1 (2%)                                
      Rathke's Cleft, Hemorrhage                       1 (2%)                    2 (4%)       2 (4%)                                
      Rathke's Cleft, Hyperplasia, Cystic                           1 (2%)                                                          
   Thyroid Gland                                      (47)         (44)         (43)         (47)                                   
      C-Cell, Hyperplasia                             45 (96%)     42 (95%)     41 (95%)     44 (94%)                               
      C-Cell, Hyperplasia, Focal                                                 1 (2%)                                             
      Follicle, Cyst                                   1 (2%)                    1 (2%)       2 (4%)                                
      Follicle, Degeneration, Cystic, Focal            2 (4%)                                                                       
      Follicle, Mineralization, Focal                 45 (96%)     43 (98%)     42 (98%)     42 (89%)                               
      Follicular Cell, Hypertrophy                     4 (9%)      13 (30%)     33 (77%)     40 (85%)                               
      Follicular Cell, Hypertrophy, Focal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)          (6)          (2)          (7)                                    
      Abdominal, Fibrosis                                                        1 (50%)                                            
      Mediastinum, Hemorrhage                                       1 (17%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                                1 (2%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)                    2 (4%)                                
   Penis                                                           (2)                                                              
      Thrombosis                                                    1 (50%)                                                         
   Preputial Gland                                    (48)         (49)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Cyst                                                          1 (2%)       1 (2%)                                             
      Degeneration, Cystic                                          2 (4%)       1 (2%)       2 (4%)                                
      Hyperplasia, Cystic                                           1 (2%)                    1 (2%)                                
      Inflammation, Chronic                           22 (46%)     12 (24%)     18 (36%)     20 (40%)                               
      Necrosis                                                                                1 (2%)                                
   Prostate                                           (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic                           21 (42%)     23 (47%)     29 (58%)     30 (60%)                               
      Mineralization, Focal                            3 (6%)       2 (4%)       3 (6%)       4 (8%)                                
      Epithelium, Hyperplasia, Focal                  11 (22%)      4 (8%)       2 (4%)      11 (22%)                               
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          4 (8%)      10 (20%)      9 (18%)      6 (12%)                               
      Bilateral, Atrophy                                            1 (2%)                                                          
      Germinal Epithelium, Atrophy                                                            1 (2%)                                
      Germinal Epithelium, Degeneration                1 (2%)                                                                       
      Interstitial Cell, Hyperplasia, Focal            1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (48)         (50)         (49)                                   
      Angiectasis                                                   1 (2%)                                                          
      Atrophy                                                                                 1 (2%)                                
      Fibrosis                                         2 (4%)                                                                       
      Hyperplasia                                     28 (58%)     35 (73%)     41 (82%)     40 (82%)                               
      Myeloid Cell, Erythroid Cell, Hyperplasia        2 (4%)                                                                       
   Lymph Node                                         (34)         (24)         (26)         (34)                                   
      Ectasia                                          1 (3%)                                                                       
      Hemorrhage                                                                              1 (3%)                                
      Deep Cervical, Hemorrhage                                                  1 (4%)                                             
      Deep Cervical, Hyperplasia, Plasma Cell          1 (3%)                                                                       
      Mediastinal, Angiectasis                                                   1 (4%)                                             
      Mediastinal, Ectasia                             5 (15%)      7 (29%)      5 (19%)      3 (9%)                                
      Mediastinal, Hemorrhage                          3 (9%)       2 (8%)       2 (8%)       1 (3%)                                
      Mediastinal, Hyperplasia, Histiocytic                         3 (13%)      2 (8%)       1 (3%)                                
      Mediastinal, Hyperplasia, Lymphoid               1 (3%)                    1 (4%)       3 (9%)                                
      Mediastinal, Hyperplasia, Plasma Cell            1 (3%)                    2 (8%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Infiltration Cellular,                                                                                           
        Polymorphonuclear                                           1 (4%)                                                          
      Mediastinal, Inflammation, Chronic Active                                               1 (3%)                                
      Mediastinal, Inflammation, Suppurative                        1 (4%)                                                          
      Pancreatic, Angiectasis                          2 (6%)                                                                       
      Pancreatic, Ectasia                              3 (9%)       3 (13%)      3 (12%)      6 (18%)                               
      Pancreatic, Hemorrhage                           5 (15%)      3 (13%)      1 (4%)       1 (3%)                                
      Pancreatic, Hyperplasia, Histiocytic             8 (24%)      5 (21%)      9 (35%)      6 (18%)                               
      Pancreatic, Hyperplasia, Lymphoid                1 (3%)       1 (4%)                                                          
      Pancreatic, Pigmentation                         1 (3%)       1 (4%)       1 (4%)                                             
      Renal, Hemorrhage                                                          1 (4%)                                             
      Renal, Hyperplasia, Focal, Histiocytic                        1 (4%)                                                          
      Renal, Hyperplasia, Lymphoid                                  1 (4%)                                                          
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (50)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Ectasia                                          1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Hemorrhage                                                    2 (4%)       3 (6%)                                             
      Hyperplasia, Focal, Histiocytic                  1 (2%)                                                                       
      Hyperplasia, Histiocytic                         3 (6%)       3 (6%)                    1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                    1 (2%)                                
   Spleen                                             (48)         (49)         (49)         (50)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Angiectasis, Focal                                            2 (4%)       1 (2%)       3 (6%)                                
      Atrophy                                                                                 1 (2%)                                
      Congestion                                       1 (2%)                                 1 (2%)                                
      Fibrosis, Focal                                               2 (4%)       2 (4%)       4 (8%)                                
      Hematopoietic Cell Proliferation                 2 (4%)       6 (12%)      4 (8%)      11 (22%)                               
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia, Focal, Histiocytic                  1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Infarct, Multiple                                                                       1 (2%)                                
      Metaplasia, Focal, Lipocyte                                                1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Pigmentation                                                                            1 (2%)                                
      Pigmentation, Focal                                                        1 (2%)                                             
      Capsule, Accessory Spleen, Focal                 1 (2%)                                                                       
      Capsule, Fibrosis, Focal                                                                1 (2%)                                
      Lymphoid Follicle, Atrophy                                    1 (2%)                                                          
   Thymus                                             (48)         (48)         (49)         (47)                                   
      Angiectasis                                                                1 (2%)                                             
      Cyst                                                          1 (2%)                                                          
      Hemorrhage                                       1 (2%)       2 (4%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                                      2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   15                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (43)         (47)         (44)                                   
      Cyst                                                                                    1 (2%)                                
      Dilatation                                       7 (16%)      7 (16%)      7 (15%)      2 (5%)                                
      Hyperplasia                                                   1 (2%)       2 (4%)       2 (5%)                                
      Inflammation, Chronic, Focal                     1 (2%)                                 1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        3 (6%)       1 (2%)       3 (6%)       1 (2%)                                
      Fibrosis, Focal                                               2 (4%)                                                          
      Hyperkeratosis, Focal                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                                  2 (4%)                                                          
      Ulcer                                                         1 (2%)                                                          
      Artery, Subcutaneous Tissue, Thrombosis                       1 (2%)                                                          
      Epidermis, Hyperplasia, Focal                    1 (2%)                                                                       
      Lip, Inflammation, Chronic, Focal                             1 (2%)                                                          
      Subcutaneous Tissue, Cyst                                     1 (2%)                                                          
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
        Inclusion                                                                1 (2%)                                             
      Subcutaneous Tissue, Hyperplasia, Focal,                                                                                      
         Histiocytic                                                                          1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
         Focal                                                      1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
         Focal, Suppurative                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Cranium, Hyperostosis                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression, Focal                               6 (12%)      6 (12%)      7 (14%)      6 (12%)                               
      Hemorrhage, Focal                                2 (4%)       2 (4%)       4 (8%)       6 (12%)                               
      Cerebrum, Ventricle, Hydrocephalus                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   16                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       2 (4%)       1 (2%)       3 (6%)                                             
      Foreign Body, Focal                              1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hemorrhage, Focal                                3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Hyperplasia, Focal, Histiocytic                               1 (2%)       1 (2%)                                             
      Hyperplasia, Histiocytic                         2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Mixed Cell                1 (2%)       3 (6%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic, Focal                     5 (10%)      2 (4%)       3 (6%)       3 (6%)                                
      Inflammation, Focal, Suppurative                              1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          8 (16%)      5 (10%)      3 (6%)       4 (8%)                                
      Alveolar Epithelium, Metaplasia, Squamous                     1 (2%)                                                          
      Alveolus, Edema, Focal                                                     1 (2%)                                             
      Alveolus, Hyperplasia, Focal, Histiocytic        1 (2%)                                                                       
      Interstitium, Edema                                           1 (2%)                    1 (2%)                                
      Mediastinum, Edema                                            1 (2%)       1 (2%)                                             
   Nose                                               (49)         (49)         (49)         (50)                                   
      Foreign Body                                                  1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)       1 (2%)       6 (12%)      1 (2%)                                
      Nasolacrimal Duct, Inflammation                  1 (2%)       3 (6%)                    1 (2%)                                
      Olfactory Epithelium, Hyperplasia, Focal                                   1 (2%)                                             
      Respiratory Epithelium, Hyperplasia, Focal                                 1 (2%)                                             
   Trachea                                            (50)         (49)         (50)         (50)                                   
      Peritracheal Tissue, Edema                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (48)         (46)         (50)                                   
      Atrophy                                                                                 2 (4%)                                
      Cataract                                                      2 (4%)       1 (2%)       2 (4%)                                
      Exudate                                                       1 (2%)                                                          
      Cornea, Inflammation, Chronic                                              1 (2%)                                             
      Cornea, Retrobulbar, Inflammation, Chronic                                                                                    
        Active                                                                                1 (2%)                                
      Retina, Degeneration                                          2 (4%)       1 (2%)       2 (4%)                                
   Harderian Gland                                    (49)         (49)         (49)         (50)                                   
      Fibrosis, Focal                                                                         1 (2%)                                
      Hyperplasia, Focal, Histiocytic                               1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic, Focal                                  1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active, Diffuse                                                   1 (2%)                                
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   17                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:20:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (47)         (46)         (49)         (49)                                   
      Cyst                                                                       1 (2%)                                             
      Cyst, Multiple                                                1 (2%)                                                          
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                                                    1 (2%)                                             
      Infarct, Multiple                                1 (2%)       1 (2%)                                                          
      Metaplasia, Focal, Lipocyte                                   1 (2%)                                                          
      Nephropathy                                     45 (96%)     44 (96%)     48 (98%)     47 (96%)                               
      Cortex, Medulla, Atrophy                                      1 (2%)                                                          
      Pelvis, Infiltration Cellular, Mixed Cell                                               1 (2%)                                
      Pelvis, Transitional Epithelium, Hyperplasia                  1 (2%)       1 (2%)                                             
      Renal Tubule, Accumulation, Hyaline Droplet                   1 (2%)       4 (8%)       2 (4%)                                
      Renal Tubule, Hyperplasia, Focal                              1 (2%)                                                          
      Renal Tubule, Pigmentation                       4 (9%)       4 (9%)       1 (2%)       4 (8%)                                
   Urinary Bladder                                    (48)         (49)         (47)         (50)                                   
      Calculus Micro Observation Only                               1 (2%)                                                          
      Edema                                                                                   2 (4%)                                
      Hemorrhage                                                                 2 (4%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Serosa, Inflammation, Focal                                                             1 (2%)                                
      Transitional Epithelium, Hyperplasia, Diffuse                 1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   18                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 133482-133482/133482


--multipart-boundary--