National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6181

TDMS Study 96010-03 Pathology Tables

NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03
Route: DOSED WATER                                                                                                Time: 13:24:09

                                                          FINAL#1/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  7775-09-9

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3            3            6            5                                     
    Moribund Sacrifice                                10           11           11            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           34           32           40                                     
    Natural Death                                                                1            1                                     
    Moribund Sacrifice                                              2                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (48)         (46)         (49)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (47)         (44)         (45)                                   
      Leiomyoma                                                     1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma                                            1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                    1 (2%)                                                          
   Mesentery                                          (18)         (10)         (13)         (16)                                   
      Carcinoma                                                                               1 (6%)                                
   Oral Mucosa                                                                  (1)          (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
   Pancreas                                           (50)         (49)         (49)         (49)                                   
      Acinus, Adenoma                                  2 (4%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
   Tooth                                                           (2)          (2)          (1)                                    
      Odontoma                                                      1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                                    1 (2%)                    1 (2%)                                
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                          2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Adenoma                                          2 (4%)       1 (2%)                                                          
      Carcinoma                                        1 (2%)       1 (2%)                    1 (2%)                                
   Pituitary Gland                                    (49)         (49)         (50)         (50)                                   
      Pars Distalis, Adenoma                          23 (47%)     18 (37%)     17 (34%)     24 (48%)                               
      Pars Distalis, Adenoma, Multiple                                                        1 (2%)                                
      Pars Distalis, Carcinoma                         1 (2%)       3 (6%)                                                          
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)                    1 (2%)                                
   Thyroid Gland                                      (47)         (47)         (43)         (46)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)       2 (4%)                                                          
      C-Cell, Adenoma                                 11 (23%)      8 (17%)     11 (26%)      9 (20%)                               
      C-Cell, Carcinoma                                1 (2%)       3 (6%)       1 (2%)       3 (7%)                                
      Follicular Cell, Adenoma                                                                2 (4%)                                
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)          (4)          (6)                                    
      Mediastinum, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                                     1 (50%)                                                         
      Mediastinum, Carcinoma, Metastatic, Zymbal's                                                                                  
          Gland                                                                  1 (25%)                                            
      Mediastinum, Histiocytic Sarcoma                                           1 (25%)                                            
      Mediastinum, Sarcoma                                                                    1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (49)                                   
      Adenoma                                         11 (22%)      5 (10%)     12 (24%)      4 (8%)                                
      Carcinoma                                        3 (6%)       1 (2%)                                                          
      Sarcoma                                                                                 1 (2%)                                
   Ovary                                              (50)         (50)         (49)         (50)                                   
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Sarcoma                                                                                 1 (2%)                                
   Oviduct                                                                      (2)                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Uterus                                             (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Mesentery                                                        1 (2%)                                
      Sarcoma Stromal                                  1 (2%)                                                                       
      Endometrium, Polyp Stromal                       8 (16%)      8 (16%)      7 (14%)      7 (14%)                               
      Endometrium, Polyp Stromal, Multiple             1 (2%)                    2 (4%)                                             
      Endometrium, Sarcoma                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
   Lymph Node                                         (36)         (34)         (30)         (39)                                   
      Mediastinal, Histiocytic Sarcoma                                           1 (3%)                                             
      Mediastinal, Sarcoma                                                                    1 (3%)                                
   Lymph Node, Mandibular                             (4)          (6)          (4)          (5)                                    
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Sarcoma                                                                                 1 (2%)                                
   Thymus                                             (49)         (48)         (48)         (48)                                   
      Sarcoma                                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                          3 (6%)                                 2 (4%)                                
      Carcinoma                                        2 (4%)       1 (2%)                    2 (4%)                                
      Carcinoma, Multiple                              1 (2%)                                                                       
      Fibroadenoma                                    23 (46%)     26 (52%)     23 (46%)     27 (54%)                               
      Fibroadenoma, Multiple                          10 (20%)      3 (6%)       8 (16%)      6 (12%)                               
      Histiocytic Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                    1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Keratoacanthoma                                                                         1 (2%)                                
      Trichoepithelioma                                2 (4%)                                                                       
      Pinna, Neural Crest Tumor                        1 (2%)                                                                       
      Subcutaneous Tissue, Carcinoma, Metastatic,                                                                                   
           Mammary Gland                                            1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     4 (8%)       1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma                      1 (2%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma,                                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
           Metastatic, Skeletal Muscle                              1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                                 (2)          (1)          (1)                                    
      Histiocytic Sarcoma                                           1 (50%)                                                         
      Rhabdomyosarcoma                                              1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland                        2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                    1 (2%)                                                          
      Sarcoma                                                                                 1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (49)         (47)         (50)                                   
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                              1 (2%)                                
   Zymbal's Gland                                     (1)                       (1)          (1)                                    
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (47)         (47)                                   
      Sarcoma                                                                                 1 (2%)                                
   Urinary Bladder                                    (50)         (48)         (50)         (50)                                   
      Transitional Epithelium, Papilloma                                                      1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)                                             
      Leukemia Mononuclear                            11 (22%)      9 (18%)     13 (26%)      9 (18%)                               
      Lymphoma Malignant                                                         1 (2%)                                             
      Mesothelioma Malignant                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          48          46          48                                       
     Total Primary Neoplasms                          133         102         101         118                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          42          44          47                                       
     Total Benign Neoplasms                           107          77          82          87                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          22          19          22                                       
     Total Malignant Neoplasms                         25          25          19          31                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           5           2           2                                       
     Total Metastatic Neoplasm                          1           8           2           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           13           11           14                                     
    Natural Death                                      3           10            8            8                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           27           31           28                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (47)         (44)         (49)                                   
   Intestine Large, Cecum                             (47)         (46)         (43)         (47)                                   
   Intestine Small, Duodenum                          (49)         (46)         (46)         (47)                                   
   Intestine Small, Jejunum                           (47)         (46)         (42)         (44)                                   
   Intestine Small, Ileum                             (47)         (46)         (42)         (47)                                   
   Liver                                              (50)         (50)         (48)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Adenoma                                        3 (6%)                                                          
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Mesentery                                          (19)         (20)         (19)         (23)                                   
      Carcinoma, Metastatic, Pancreas                               1 (5%)                                                          
      Hemangiosarcoma, Metastatic, Liver                            1 (5%)                                                          
      Histiocytic Sarcoma                              1 (5%)       1 (5%)                                                          
      Osteosarcoma                                     1 (5%)                                                                       
   Pancreas                                           (49)         (49)         (49)         (50)                                   
      Hemangiosarcoma, Metastatic, Liver                            1 (2%)                                                          
      Acinus, Adenoma                                               2 (4%)       1 (2%)                                             
      Acinus, Adenoma, Multiple                                     1 (2%)                                                          
      Acinus, Carcinoma                                             1 (2%)                                                          
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Fibrosarcoma                                                               1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                             1 (2%)                                                                       
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (49)         (48)         (48)         (50)                                   
   Tongue                                             (1)          (1)          (1)          (1)                                    
      Sarcoma                                                                    1 (100%)                                           
      Squamous Cell Carcinoma                                       1 (100%)                                                        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                       (2)                                                 
      Aorta, Osteosarcoma                              1 (100%)                                                                     
   Heart                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
      Schwannoma Benign                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (49)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Adrenal Medulla                                    (49)         (49)         (50)         (50)                                   
      Ganglioneuroma                                                1 (2%)                                                          
      Pheochromocytoma Malignant                       3 (6%)                    1 (2%)       1 (2%)                                
      Pheochromocytoma Benign                          6 (12%)      3 (6%)       3 (6%)       5 (10%)                               
      Bilateral, Ganglioneuroma                                                               1 (2%)                                
      Bilateral, Pheochromocytoma Benign                            1 (2%)                    3 (6%)                                
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Adenoma                                          3 (6%)       4 (8%)       3 (6%)       5 (10%)                               
      Carcinoma                                        2 (4%)       1 (2%)                    2 (4%)                                
   Pituitary Gland                                    (48)         (50)         (49)         (50)                                   
      Pars Distalis, Adenoma                          16 (33%)     15 (30%)     20 (41%)     15 (30%)                               
      Pars Intermedia, Adenoma                                      1 (2%)                    1 (2%)                                
   Thyroid Gland                                      (47)         (44)         (43)         (47)                                   
      Bilateral, C-Cell, Adenoma, Multiple                                       1 (2%)                                             
      C-Cell, Adenoma                                  9 (19%)      9 (20%)      5 (12%)      9 (19%)                               
      C-Cell, Carcinoma                                2 (4%)       2 (5%)                    1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                                 2 (4%)                                
      Follicular Cell, Carcinoma                                                              4 (9%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)          (1)                                                 
   Tissue NOS                                         (5)          (6)          (2)          (7)                                    
      Abdominal, Paraganglioma                         1 (20%)                                                                      
      Mediastinum, Carcinoma, Metastatic, Zymbal's                                                                                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENERAL BODY SYSTEM - cont                                                                                                          
          Gland                                                     1 (17%)                                                         
      Mediastinum, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Lung                                          1 (17%)                                                         
      Pelvic, Leiomyoma                                1 (20%)                                                                      
      Thoracic, Fibroma                                                                       1 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (48)         (49)         (50)         (50)                                   
      Adenoma                                          1 (2%)       6 (12%)      5 (10%)      5 (10%)                               
      Carcinoma                                        3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
   Prostate                                           (50)         (49)         (50)         (50)                                   
   Seminal Vesicle                                    (50)         (49)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma                                                   1 (2%)                                
      Bilateral, Interstitial Cell, Adenoma,                                                                                        
          Multiple                                    40 (80%)     43 (86%)     42 (84%)     39 (78%)                               
      Interstitial Cell, Adenoma                       2 (4%)       1 (2%)                    2 (4%)                                
      Interstitial Cell, Adenoma, Multiple             3 (6%)       5 (10%)      2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (48)         (50)         (49)                                   
   Lymph Node                                         (34)         (24)         (26)         (34)                                   
      Histiocytic Sarcoma                              1 (3%)                                                                       
      Deep Cervical, Histiocytic Sarcoma               1 (3%)                                                                       
      Mediastinal, Carcinoma, Metastatic, Zymbal's                                                                                  
          Gland                                                     1 (4%)                                                          
   Lymph Node, Mandibular                             (3)          (2)          (3)          (4)                                    
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (50)                                   
   Spleen                                             (48)         (49)         (49)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Capsule, Carcinoma, Metastatic, Pancreas                      1 (2%)                                                          
   Thymus                                             (48)         (48)         (49)         (47)                                   
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Thymoma Benign                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (43)         (47)         (44)                                   
      Carcinoma                                                     1 (2%)       1 (2%)                                             
      Fibroadenoma                                     2 (4%)       1 (2%)       4 (9%)       4 (9%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Carcinoma                                          1 (2%)                    2 (4%)                                
      Basal Cell Carcinoma, Multiple                                1 (2%)                                                          
      Keratoacanthoma                                  4 (8%)       2 (4%)       1 (2%)       1 (2%)                                
      Trichoepithelioma                                1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     9 (18%)      9 (18%)      4 (8%)       7 (14%)                               
      Subcutaneous Tissue, Fibroma, Multiple                        1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       2 (4%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma                      1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Neural Crest Tumor          1 (2%)                                                                       
      Subcutaneous Tissue, Osteosarcoma                                                       1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
      Periosteum, Cranium, Fibrosarcoma,                                                                                            
          Metastatic, Skin                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
      Glioma Malignant                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       2 (4%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Uncertain                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Primary Site                                 1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Squamous Cell Carcinoma                                       1 (2%)                                                          
   Nose                                               (49)         (49)         (49)         (50)                                   
   Trachea                                            (50)         (49)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (48)         (46)         (50)                                   
      Retrobulbar, Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                          
   Harderian Gland                                    (49)         (49)         (49)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
   Zymbal's Gland                                                  (1)          (1)          (3)                                    
      Carcinoma                                                     1 (100%)     1 (100%)     1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (47)         (46)         (49)         (49)                                   
      Lipoma                                                        1 (2%)                    1 (2%)                                
      Mesenchymal Tumor Benign                                                   1 (2%)                                             
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (48)         (49)         (47)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Leukemia Mononuclear                            13 (26%)     21 (42%)     16 (32%)     23 (46%)                               
      Lymphoma Malignant                               1 (2%)                                                                       
      Mesothelioma Malignant                                        1 (2%)       2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03  
Route: DOSED WATER                                                                                                Time: 13:24:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       125 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          50          50                                       
     Total Primary Neoplasms                          135         152         124         150                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          49          47          47                                       
     Total Benign Neoplasms                           100         112          97         108                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          32          24          32                                       
     Total Malignant Neoplasms                         34          40          27          42                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           5                       1                                       
     Total Metastatic Neoplasm                          3          10                       3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 96163-96163/96163


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.