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TDMS Study 96010-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 05/27/03       
EXPERIMENT: 96010 TEST: 03                                                                                     TIME: 13:29:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 7775-09-9       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 05/27/03       
EXPERIMENT: 96010 TEST: 03                                                                                     TIME: 13:29:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 7775-09-9       
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Salivary Glands                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 05/27/03       
EXPERIMENT: 96010 TEST: 03                                                                                     TIME: 13:29:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 7775-09-9       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF     WATER DISINFECTION BYPRODUCTS (SODIUM                                                                        
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Clitoral/Preputial Gland               Adenoma                                                                                      
Pancreas                               Carcinoma or Adenoma                                                                         
Testes                                 Adenoma                                                                                      
Thyroid Gland: Follicular Cell         Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Osteosarcoma                                                                                 
                                       Osteosarcoma or Osteoma                                                                      
                                       Benign Tumors                                                                                
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Clitoral/Preputial Gland               Adenoma                                                                                      
                                       Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
Mammary Gland                          Carcinoma or Adenoma                                                                         
Pancreas                               Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Skin                                                                                                                                
Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, malignant or NOS), or Trichoepithelioma                       
Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom                                                                                                                 
                                       Trichoepithelioma                                                                            
Thyroid Gland: Follicular Cell         Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
===============================================================                                                                     
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -      WATER DISINFECTION BYPRODUCTS (SODIUM
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/49 (12%)   4/49 (8%)    3/50 (6%)    8/50 (16%)  |2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     6/43.39      4/43.76      3/43.85      8/43.70     |2/44.75      1/43.69      1/43.24      1/47.00      | 
|POLY-3 PERCENT (g) |     13.8%        9.1%         6.8%         18.3%       |4.5%         2.3%         2.3%         2.1%         | 
|TERMINAL (d)       |     6/36 (17%)   3/27 (11%)   2/31 (7%)    5/28 (18%)  |2/37 (5%)    1/36 (3%)    1/33 (3%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      555          698          699         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.169      P=0.531N     P=0.316N     P=0.229     |P=0.405N     P=0.510N     P=0.540N     P=0.464N     | 
|POLY 3             |     P=0.229      P=0.364N     P=0.236N     P=0.391     |P=0.423N     P=0.508N     P=0.512N     P=0.483N     | 
|POLY 1.5           |     P=0.234      P=0.361N     P=0.234N     P=0.399     |P=0.428N     P=0.506N     P=0.506N     P=0.489N     | 
|POLY 6             |     P=0.223      P=0.378N     P=0.243N     P=0.373     |P=0.418N     P=0.511N     P=0.522N     P=0.477N     | 
|LOGISTIC REGRESSION|     P=0.218      P=0.378N     P=0.274N     P=0.310     |P=0.405N     P=0.510N     P=0.540N     P=0.464N     | 
|COCH-ARM / FISHERS |     P=0.241      P=0.370N     P=0.233N     P=0.403     |P=0.437N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.177      (e)          (e)          (e)         |P=0.393N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    0/49 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/43.39      0/43.20      1/43.97      1/43.44     |0/44.75      1/44.28      0/43.24      1/47.00      | 
|POLY-3 PERCENT (g) |     6.9%         0.0%         2.3%         2.3%        |0.0%         2.3%         0.0%         2.1%         | 
|TERMINAL (d)       |     3/36 (8%)    0/27 (0%)    0/31 (0%)    1/28 (4%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          667          729 (T)     |---          541          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443N     P=0.176N     P=0.347N     P=0.398N    |P=0.495      P=0.496      (e)          P=0.520      | 
|POLY 3             |     P=0.404N     P=0.119N     P=0.300N     P=0.305N    |P=0.488      P=0.498      (e)          P=0.510      | 
|POLY 1.5           |     P=0.405N     P=0.118N     P=0.299N     P=0.300N    |P=0.484      P=0.498      (e)          P=0.506      | 
|POLY 6             |     P=0.400N     P=0.125N     P=0.305N     P=0.315N    |P=0.492      P=0.498      (e)          P=0.513      | 
|LOGISTIC REGRESSION|     P=0.414N     (e)          P=0.305N     P=0.398N    |P=0.422      P=0.570      (e)          P=0.520      | 
|COCH-ARM / FISHERS |     P=0.401N     P=0.121N     P=0.301N     P=0.301N    |P=0.478      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.101N     (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/49 (18%)   4/49 (8%)    4/50 (8%)    9/50 (18%)  |2/50 (4%)    2/50 (4%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     9/43.39      4/43.76      4/44.09      9/43.70     |2/44.75      2/44.28      1/43.24      3/47.00      | 
|POLY-3 PERCENT (g) |     20.7%        9.1%         9.1%         20.6%       |4.5%         4.5%         2.3%         6.4%         | 
|TERMINAL (d)       |     9/36 (25%)   3/27 (11%)   2/31 (7%)    6/28 (21%)  |2/37 (5%)    1/36 (3%)    1/33 (3%)    3/41 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      555          667          699         |729 (T)      541          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.250      P=0.237N     P=0.175N     P=0.389     |P=0.454      P=0.684      P=0.540N     P=0.547      | 
|POLY 3             |     P=0.331      P=0.110N     P=0.107N     P=0.598N    |P=0.430      P=0.690      P=0.512N     P=0.522      | 
|POLY 1.5           |     P=0.336      P=0.109N     P=0.108N     P=0.588N    |P=0.423      P=0.691      P=0.506N     P=0.514      | 
|POLY 6             |     P=0.327      P=0.117N     P=0.110N     P=0.591     |P=0.435      P=0.690      P=0.522N     P=0.530      | 
|LOGISTIC REGRESSION|     P=0.317      P=0.126N     P=0.126N     P=0.498     |P=0.426      P=0.691N     P=0.540N     P=0.547      | 
|COCH-ARM / FISHERS |     P=0.347      P=0.116N     P=0.109N     P=0.584N    |P=0.411      P=0.691N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.240N     (e)          (e)          (e)         |P=0.430      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    6/49 (12%)   5/50 (10%)   5/50 (10%)  |11/49 (22%)  5/50 (10%)   12/50 (24%)  4/49 (8%)    | 
|POLY-3 RATE (b)    |     1/42.39      6/43.79      5/44.22      5/44.37     |11/44.20     5/43.69      12/44.69     4/46.00      | 
|POLY-3 PERCENT (g) |     2.4%         13.7%        11.3%        11.3%       |24.9%        11.4%        26.9%        8.7%         | 
|TERMINAL (d)       |     1/35 (3%)    5/27 (19%)   3/31 (10%)   3/28 (11%)  |10/36 (28%)  5/36 (14%)   8/33 (24%)   4/40 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      542          626          465         |595          729 (T)      511          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.227      P=0.031 *    P=0.086      P=0.075     |P=0.132N     P=0.083N     P=0.418      P=0.028N*    | 
|POLY 3             |     P=0.287      P=0.060      P=0.111      P=0.111     |P=0.131N     P=0.085N     P=0.512      P=0.035N*    | 
|POLY 1.5           |     P=0.289      P=0.062      P=0.111      P=0.113     |P=0.147N     P=0.083N     P=0.518      P=0.038N*    | 
|POLY 6             |     P=0.277      P=0.056      P=0.108      P=0.107     |P=0.119N     P=0.089N     P=0.499      P=0.033N*    | 
|LOGISTIC REGRESSION|     P=0.287      P=0.062      P=0.110      P=0.112     |P=0.150N     P=0.086N     P=0.499      P=0.034N*    | 
|COCH-ARM / FISHERS |     P=0.287      P=0.059      P=0.112      P=0.112     |P=0.179N     P=0.079N     P=0.522      P=0.045N*    | 
|ORDER RESTRICTED   |     P=0.096      (e)          (e)          (e)         |P=0.028N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/48 (6%)    1/49 (2%)    2/50 (4%)    2/50 (4%)   |3/49 (6%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/43.05      1/43.20      2/43.76      2/43.91     |3/43.75      1/43.69      0/43.24      0/46.00      | 
|POLY-3 PERCENT (g) |     7.0%         2.3%         4.6%         4.6%        |6.9%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/35 (6%)    1/27 (4%)    1/31 (3%)    1/28 (4%)   |3/36 (8%)    1/36 (3%)    0/33 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     511          729 (T)      721          590         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.573      P=0.369N     P=0.539N     P=0.554N    |P=0.054N     P=0.305N     P=0.136N     P=0.103N     | 
|POLY 3             |     P=0.555N     P=0.304N     P=0.492N     P=0.491N    |P=0.054N     P=0.305N     P=0.120N     P=0.110N     | 
|POLY 1.5           |     P=0.554N     P=0.299N     P=0.488N     P=0.485N    |P=0.055N     P=0.303N     P=0.118N     P=0.113N     | 
|POLY 6             |     P=0.555N     P=0.317N     P=0.504N     P=0.503N    |P=0.054N     P=0.307N     P=0.125N     P=0.107N     | 
|LOGISTIC REGRESSION|     P=0.549N     P=0.308N     P=0.481N     P=0.488N    |P=0.054N     P=0.305N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.551N     P=0.301N     P=0.480N     P=0.480N    |P=0.058N     P=0.301N     P=0.117N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.386N     (e)          (e)          (e)         |P=0.018N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/48 (8%)    7/49 (14%)   7/50 (14%)   6/50 (12%)  |14/49 (29%)  6/50 (12%)   12/50 (24%)  4/49 (8%)    | 
|POLY-3 RATE (b)    |     4/43.05      7/43.79      7/44.25      6/44.84     |14/44.20     6/43.69      12/44.69     4/46.00      | 
|POLY-3 PERCENT (g) |     9.3%         16.0%        15.8%        13.4%       |31.7%        13.7%        26.9%        8.7%         | 
|TERMINAL (d)       |     3/35 (9%)    6/27 (22%)   4/31 (13%)   3/28 (11%)  |13/36 (36%)  6/36 (17%)   8/33 (24%)   4/40 (10%)   | 
|FIRST INCIDENCE    |     511          542          626          465         |595          729 (T)      511          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.372      P=0.162      P=0.218      P=0.296     |P=0.039N*    P=0.036N*    P=0.502N     P=0.004N**   | 
|POLY 3             |     P=0.461      P=0.270      P=0.276      P=0.395     |P=0.036N*    P=0.037N*    P=0.395N     P=0.005N**   | 
|POLY 1.5           |     P=0.463      P=0.276      P=0.280      P=0.398     |P=0.042N*    P=0.036N*    P=0.389N     P=0.006N**   | 
|POLY 6             |     P=0.454      P=0.251      P=0.266      P=0.384     |P=0.031N*    P=0.039N*    P=0.408N     P=0.005N**   | 
|LOGISTIC REGRESSION|     P=0.463      P=0.273      P=0.283      P=0.389     |P=0.044N*    P=0.039N*    P=0.417N     P=0.006N**   | 
|COCH-ARM / FISHERS |     P=0.462      P=0.274      P=0.286      P=0.397     |P=0.059N     P=0.035N*    P=0.387N     P=0.009N**   | 
|ORDER RESTRICTED   |     P=0.344      (e)          (e)          (e)         |P=0.003N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/49 (8%)    3/49 (6%)    5/50 (10%)  |2/50 (4%)    1/49 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/43.72      4/43.59      3/43.52      5/43.62     |2/44.75      1/43.02      0/42.24      0/47.00      | 
|POLY-3 PERCENT (g) |     6.9%         9.2%         6.9%         11.5%       |4.5%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/36 (8%)    2/27 (7%)    2/31 (7%)    4/28 (14%)  |2/37 (5%)    1/36 (3%)    0/32 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      663          714          681         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.274      P=0.381      P=0.597      P=0.238     |P=0.102N     P=0.510N     P=0.271N     P=0.216N     | 
|POLY 3             |     P=0.335      P=0.498      P=0.661      P=0.355     |P=0.104N     P=0.514N     P=0.250N     P=0.226N     | 
|POLY 1.5           |     P=0.338      P=0.499      P=0.658      P=0.358     |P=0.105N     P=0.512N     P=0.246N     P=0.230N     | 
|POLY 6             |     P=0.327      P=0.488      P=0.657      P=0.343     |P=0.104N     P=0.515N     P=0.257N     P=0.223N     | 
|LOGISTIC REGRESSION|     P=0.321      P=0.482      P=0.626      P=0.310     |P=0.102N     P=0.510N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.339      P=0.489      P=0.651      P=0.357     |P=0.106N     P=0.508N     P=0.253N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.355      (e)          (e)          (e)         |P=0.067N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    0/49 (0%)    2/50 (4%)   |1/50 (2%)    1/49 (2%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.72      1/43.20      0/43.46      2/43.55     |1/44.75      1/43.02      0/42.24      1/47.00      | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         0.0%         4.6%        |2.2%         2.3%         0.0%         2.1%         | 
|TERMINAL (d)       |     2/36 (6%)    1/27 (4%)    0/31 (0%)    1/28 (4%)   |1/37 (3%)    1/36 (3%)    0/32 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          701         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.523      P=0.600N     P=0.272N     P=0.614     |P=0.553N     P=0.756      P=0.529N     P=0.739N     | 
|POLY 3             |     P=0.564      P=0.504N     P=0.238N     P=0.693     |P=0.577N     P=0.752      P=0.511N     P=0.750N     | 
|POLY 1.5           |     P=0.564      P=0.503N     P=0.239N     P=0.693N    |P=0.577N     P=0.753      P=0.508N     P=0.754N     | 
|POLY 6             |     P=0.564      P=0.513N     P=0.241N     P=0.685     |P=0.578N     P=0.751      P=0.517N     P=0.746N     | 
|LOGISTIC REGRESSION|     P=0.546      P=0.600N     (e)          P=0.671     |P=0.553N     P=0.756      (e)          P=0.739N     | 
|COCH-ARM / FISHERS |     P=0.565      P=0.508N     P=0.253N     P=0.691N    |P=0.579N     P=0.747      P=0.505N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.413      (e)          (e)          (e)         |P=0.522N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   5/49 (10%)   3/49 (6%)    7/50 (14%)  |3/50 (6%)    2/49 (4%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/43.72      5/43.59      3/43.52      7/43.73     |3/44.75      2/43.02      0/42.24      1/47.00      | 
|POLY-3 PERCENT (g) |     11.4%        11.5%        6.9%         16.0%       |6.7%         4.7%         0.0%         2.1%         | 
|TERMINAL (d)       |     5/36 (14%)   3/27 (11%)   2/31 (7%)    5/28 (18%)  |3/37 (8%)    2/36 (6%)    0/32 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      663          714          681         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.259      P=0.472      P=0.436N     P=0.234     |P=0.144N     P=0.513N     P=0.147N     P=0.269N     | 
|POLY 3             |     P=0.331      P=0.629      P=0.358N     P=0.379     |P=0.153N     P=0.518N     P=0.129N     P=0.288N     | 
|POLY 1.5           |     P=0.333      P=0.629      P=0.361N     P=0.382     |P=0.154N     P=0.516N     P=0.126N     P=0.294N     | 
|POLY 6             |     P=0.325      P=0.618      P=0.363N     P=0.365     |P=0.152N     P=0.519N     P=0.135N     P=0.282N     | 
|LOGISTIC REGRESSION|     P=0.311      P=0.597      P=0.407N     P=0.324     |P=0.144N     P=0.513N     (e)          P=0.269N     | 
|COCH-ARM / FISHERS |     P=0.335      P=0.617      P=0.369N     P=0.380     |P=0.157N     P=0.510N     P=0.125N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.296      (e)          (e)          (e)         |P=0.101N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/48 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.72      3/43.80      0/42.88      0/43.44     |0/44.75      0/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         6.9%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    3/27 (11%)   0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.161N     P=0.075      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.141N     P=0.119      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.140N     P=0.120      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.146N     P=0.113      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.075      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.146N     P=0.121      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.164N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.72      1/43.80      2/43.73      0/43.44     |1/44.75      1/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         4.6%         0.0%        |2.2%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/36 (3%)    1/27 (4%)    2/31 (7%)    0/28 (0%)   |1/37 (3%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.414N     P=0.697      P=0.448      P=0.550N    |P=0.195N     P=0.756      P=0.523N     P=0.480N     | 
|POLY 3             |     P=0.379N     P=0.760N     P=0.500      P=0.501N    |P=0.204N     P=0.755      P=0.507N     P=0.490N     | 
|POLY 1.5           |     P=0.378N     P=0.758N     P=0.501      P=0.500N    |P=0.204N     P=0.757      P=0.504N     P=0.494N     | 
|POLY 6             |     P=0.383N     P=0.754      P=0.495      P=0.506N    |P=0.205N     P=0.754      P=0.512N     P=0.487N     | 
|LOGISTIC REGRESSION|     P=0.414N     P=0.697      P=0.448      (e)         |P=0.195N     P=0.756      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.376N     P=0.753N     P=0.500      P=0.500N    |P=0.203N     P=0.753N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.273N     (e)          (e)          (e)         |P=0.237N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/43.72      2/43.80      0/43.73      1/43.44     |1/44.75      0/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     6.9%         4.6%         0.0%         2.3%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/36 (8%)    2/27 (7%)    0/31 (0%)    1/28 (4%)   |1/37 (3%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.186N     P=0.631N     P=0.148N     P=0.398N    |P=0.352N     P=0.505N     P=0.523N     P=0.480N     | 
|POLY 3             |     P=0.159N     P=0.499N     P=0.118N     P=0.307N    |P=0.365N     P=0.505N     P=0.507N     P=0.490N     | 
|POLY 1.5           |     P=0.159N     P=0.496N     P=0.118N     P=0.305N    |P=0.364N     P=0.503N     P=0.504N     P=0.494N     | 
|POLY 6             |     P=0.158N     P=0.513N     P=0.121N     P=0.316N    |P=0.366N     P=0.506N     P=0.512N     P=0.487N     | 
|LOGISTIC REGRESSION|     P=0.186N     P=0.631N     (e)          P=0.398N    |P=0.352N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.158N     P=0.500N     P=0.121N     P=0.309N    |P=0.363N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.108N     (e)          (e)          (e)         |P=0.111N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    2/50 (4%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/43.72      3/43.80      2/43.73      1/43.44     |2/44.75      1/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     9.2%         6.9%         4.6%         2.3%        |4.5%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/36 (11%)   3/27 (11%)   2/31 (7%)    1/28 (4%)   |2/37 (5%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.147N     P=0.656      P=0.407N     P=0.261N    |P=0.101N     P=0.510N     P=0.264N     P=0.216N     | 
|POLY 3             |     P=0.119N     P=0.499N     P=0.337N     P=0.180N    |P=0.104N     P=0.508N     P=0.245N     P=0.226N     | 
|POLY 1.5           |     P=0.119N     P=0.495N     P=0.336N     P=0.178N    |P=0.105N     P=0.506N     P=0.241N     P=0.230N     | 
|POLY 6             |     P=0.119N     P=0.516N     P=0.343N     P=0.187N    |P=0.104N     P=0.511N     P=0.251N     P=0.223N     | 
|LOGISTIC REGRESSION|     P=0.147N     P=0.656      P=0.407N     P=0.261N    |P=0.101N     P=0.510N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.500N     P=0.339N     P=0.181N    |P=0.106N     P=0.500N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.131N     (e)          (e)          (e)         |P=0.067N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.72      0/43.80      0/43.73      0/43.44     |3/44.75      0/43.69      0/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.7%         0.0%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |3/37 (8%)    0/36 (0%)    0/33 (0%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.594N     P=0.126N     P=0.142N     P=0.453N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.609      P=0.123N     P=0.125N     P=0.478N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.603      P=0.122N     P=0.122N     P=0.486N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.614      P=0.124N     P=0.130N     P=0.470N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.594N     (e)          (e)          P=0.453N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.591      P=0.121N     P=0.121N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.094N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.72      1/43.81      1/43.73      0/43.44     |3/46.46      1/44.28      0/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.3%         0.0%        |6.5%         2.3%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    1/31 (3%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          726          729 (T)      ---         |462          541          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.553N     P=0.450      P=0.470      (e)         |P=0.460N     P=0.320N     P=0.129N     P=0.470N     | 
|POLY 3             |     P=0.523N     P=0.500      P=0.500      (e)         |P=0.483N     P=0.323N     P=0.132N     P=0.495N     | 
|POLY 1.5           |     P=0.522N     P=0.502      P=0.500      (e)         |P=0.484N     P=0.317N     P=0.126N     P=0.496N     | 
|POLY 6             |     P=0.530N     P=0.494      P=0.497      (e)         |P=0.484N     P=0.329N     P=0.141N     P=0.494N     | 
|LOGISTIC REGRESSION|     P=0.545N     P=0.472      P=0.470      (e)         |P=0.587      P=0.183N     P=0.091N     P=0.685N     | 
|COCH-ARM / FISHERS |     P=0.522N     P=0.500      P=0.500      (e)         |P=0.487N     P=0.309N     P=0.121N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.400      (e)          (e)          (e)         |P=0.191N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |6/50 (12%)   1/50 (2%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/43.72      1/43.81      1/43.73      0/43.44     |6/46.46      1/44.28      0/43.24      4/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.3%         0.0%        |12.9%        2.3%         0.0%         8.5%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    1/31 (3%)    0/28 (0%)   |3/37 (8%)    0/36 (0%)    0/33 (0%)    4/41 (10%)   | 
|FIRST INCIDENCE    |     ---          726          729 (T)      ---         |462          541          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.553N     P=0.450      P=0.470      (e)         |P=0.461N     P=0.069N     P=0.024N*    P=0.321N     | 
|POLY 3             |     P=0.523N     P=0.500      P=0.500      (e)         |P=0.494N     P=0.064N     P=0.019N*    P=0.362N     | 
|POLY 1.5           |     P=0.522N     P=0.502      P=0.500      (e)         |P=0.497N     P=0.061N     P=0.018N*    P=0.365N     | 
|POLY 6             |     P=0.530N     P=0.494      P=0.497      (e)         |P=0.494N     P=0.067N     P=0.022N*    P=0.362N     | 
|LOGISTIC REGRESSION|     P=0.545N     P=0.472      P=0.470      (e)         |P=0.576N     P=0.037N*    P=0.013N*    P=0.452N     | 
|COCH-ARM / FISHERS |     P=0.522N     P=0.500      P=0.500      (e)         |P=0.505N     P=0.056N     P=0.013N*    P=0.370N     | 
|ORDER RESTRICTED   |     P=0.400      (e)          (e)          (e)         |P=0.038N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    4/50 (8%)    4/50 (8%)   |33/50 (66%)  29/50 (58%)  31/50 (62%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     2/43.72      1/43.80      4/44.26      4/43.48     |33/47.28     29/45.65     31/45.14     33/47.81     | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         9.0%         9.2%        |69.8%        63.5%        68.7%        69.0%        | 
|TERMINAL (d)       |     2/36 (6%)    1/27 (4%)    3/31 (10%)   3/28 (11%)  |26/37 (70%)  25/36 (69%)  24/33 (73%)  29/41 (71%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      566          718         |423          365          547          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.090      P=0.600N     P=0.287      P=0.234     |P=0.429N     P=0.335N     P=0.476      P=0.335N     | 
|POLY 3             |     P=0.118      P=0.499N     P=0.343      P=0.334     |P=0.437      P=0.333N     P=0.544N     P=0.557N     | 
|POLY 1.5           |     P=0.119      P=0.497N     P=0.341      P=0.338     |P=0.414      P=0.304N     P=0.487N     P=0.566N     | 
|POLY 6             |     P=0.116      P=0.510N     P=0.338      P=0.323     |P=0.462      P=0.376N     P=0.567      P=0.551N     | 
|LOGISTIC REGRESSION|     P=0.115      P=0.600N     P=0.337      P=0.261     |P=0.531      P=0.300N     P=0.483N     P=0.469N     | 
|COCH-ARM / FISHERS |     P=0.121      P=0.500N     P=0.339      P=0.339     |P=0.379      P=0.268N     P=0.418N     P=0.583N     | 
|ORDER RESTRICTED   |     P=0.210      (e)          (e)          (e)         |P=0.599N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    4/50 (8%)    4/50 (8%)   |35/50 (70%)  29/50 (58%)  31/50 (62%)  34/50 (68%)  | 
|POLY-3 RATE (b)    |     2/43.72      1/43.80      4/44.26      4/43.48     |35/47.28     29/45.65     31/45.14     34/47.81     | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         9.0%         9.2%        |74.0%        63.5%        68.7%        71.1%        | 
|TERMINAL (d)       |     2/36 (6%)    1/27 (4%)    3/31 (10%)   3/28 (11%)  |28/37 (76%)  25/36 (69%)  24/33 (73%)  30/41 (73%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      566          718         |423          365          547          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.090      P=0.600N     P=0.287      P=0.234     |P=0.399N     P=0.206N     P=0.533N     P=0.254N     | 
|POLY 3             |     P=0.118      P=0.499N     P=0.343      P=0.334     |P=0.466      P=0.184N     P=0.362N     P=0.464N     | 
|POLY 1.5           |     P=0.119      P=0.497N     P=0.341      P=0.338     |P=0.441      P=0.167N     P=0.315N     P=0.477N     | 
|POLY 6             |     P=0.116      P=0.510N     P=0.338      P=0.323     |P=0.494      P=0.214N     P=0.438N     P=0.455N     | 
|LOGISTIC REGRESSION|     P=0.115      P=0.600N     P=0.337      P=0.261     |P=0.510N     P=0.170N     P=0.316N     P=0.366N     | 
|COCH-ARM / FISHERS |     P=0.121      P=0.500N     P=0.339      P=0.339     |P=0.402      P=0.149N     P=0.263N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.210      (e)          (e)          (e)         |P=0.391N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    5/50 (10%)   4/50 (8%)   |37/50 (74%)  30/50 (60%)  31/50 (62%)  35/50 (70%)  | 
|POLY-3 RATE (b)    |     2/43.72      2/43.81      5/44.26      4/43.48     |37/48.68     30/46.24     31/45.14     35/47.81     | 
|POLY-3 PERCENT (g) |     4.6%         4.6%         11.3%        9.2%        |76.0%        64.9%        68.7%        73.2%        | 
|TERMINAL (d)       |     2/36 (6%)    1/27 (4%)    4/31 (13%)   3/28 (11%)  |28/37 (76%)  25/36 (69%)  24/33 (73%)  31/41 (76%)  | 
|FIRST INCIDENCE    |     729 (T)      726          566          718         |423          365          547          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.134      P=0.590      P=0.172      P=0.234     |P=0.334N     P=0.169N     P=0.386N     P=0.198N     | 
|POLY 3             |     P=0.173      P=0.693N     P=0.221      P=0.334     |P=0.466      P=0.161N     P=0.280N     P=0.466N     | 
|POLY 1.5           |     P=0.176      P=0.690N     P=0.220      P=0.338     |P=0.470      P=0.134N     P=0.214N     P=0.445N     | 
|POLY 6             |     P=0.168      P=0.684      P=0.216      P=0.323     |P=0.460      P=0.198N     P=0.378N     P=0.491N     | 
|LOGISTIC REGRESSION|     P=0.168      P=0.621      P=0.216      P=0.261     |P=0.474N     P=0.109N     P=0.162N     P=0.350N     | 
|COCH-ARM / FISHERS |     P=0.177      P=0.691N     P=0.218      P=0.339     |P=0.474      P=0.101N     P=0.142N     P=0.412N     | 
|ORDER RESTRICTED   |     P=0.248      (e)          (e)          (e)         |P=0.338N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    3/49 (6%)    1/49 (2%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.39      3/43.20      1/43.46      0/43.44     |2/44.75      0/43.02      0/42.24      0/46.34      | 
|POLY-3 PERCENT (g) |     0.0%         6.9%         2.3%         0.0%        |4.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    3/27 (11%)   1/31 (3%)    0/28 (0%)   |2/37 (5%)    0/36 (0%)    0/32 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.243N     P=0.075      P=0.470      (e)         |P=0.168N     P=0.244N     P=0.271N     P=0.216N     | 
|POLY 3             |     P=0.214N     P=0.118      P=0.500      (e)         |P=0.172N     P=0.246N     P=0.250N     P=0.229N     | 
|POLY 1.5           |     P=0.211N     P=0.120      P=0.501      (e)         |P=0.172N     P=0.245N     P=0.246N     P=0.234N     | 
|POLY 6             |     P=0.224N     P=0.112      P=0.497      (e)         |P=0.172N     P=0.246N     P=0.257N     P=0.225N     | 
|LOGISTIC REGRESSION|     (e)          P=0.075      P=0.470      (e)         |P=0.168N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.212N     P=0.121      P=0.500      (e)         |P=0.175N     P=0.253N     P=0.253N     P=0.253N     | 
|ORDER RESTRICTED   |     P=0.218N     (e)          (e)          (e)         |P=0.027N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    4/49 (8%)    1/49 (2%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.39      4/43.20      1/43.46      0/43.44     |2/44.75      0/43.02      0/42.24      0/46.34      | 
|POLY-3 PERCENT (g) |     0.0%         9.3%         2.3%         0.0%        |4.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    4/27 (15%)   1/31 (3%)    0/28 (0%)   |2/37 (5%)    0/36 (0%)    0/32 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.164N     P=0.032 *    P=0.470      (e)         |P=0.168N     P=0.244N     P=0.271N     P=0.216N     | 
|POLY 3             |     P=0.138N     P=0.059      P=0.500      (e)         |P=0.172N     P=0.246N     P=0.250N     P=0.229N     | 
|POLY 1.5           |     P=0.135N     P=0.061      P=0.501      (e)         |P=0.172N     P=0.245N     P=0.246N     P=0.234N     | 
|POLY 6             |     P=0.146N     P=0.055      P=0.497      (e)         |P=0.172N     P=0.246N     P=0.257N     P=0.225N     | 
|LOGISTIC REGRESSION|     (e)          P=0.032 *    P=0.470      (e)         |P=0.168N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.138N     P=0.059      P=0.500      (e)         |P=0.175N     P=0.253N     P=0.253N     P=0.253N     | 
|ORDER RESTRICTED   |     P=0.148N     (e)          (e)          (e)         |P=0.027N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/48 (33%)  15/50 (30%)  20/49 (41%)  15/50 (30%) |23/49 (47%)  18/49 (37%)  17/50 (34%)  25/50 (50%)  | 
|POLY-3 RATE (b)    |     16/43.05     15/44.42     20/45.67     15/44.68    |23/46.10     18/43.93     17/46.64     25/48.71     | 
|POLY-3 PERCENT (g) |     37.2%        33.8%        43.8%        33.6%       |49.9%        41.0%        36.5%        51.3%        | 
|TERMINAL (d)       |     13/36 (36%)  11/27 (41%)  12/31 (39%)  8/28 (29%)  |16/36 (44%)  15/36 (42%)  9/33 (27%)   20/41 (49%)  | 
|FIRST INCIDENCE    |     630          652          561          651         |511          626          511          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.375      P=0.351      P=0.166      P=0.423     |P=0.430      P=0.233N     P=0.260N     P=0.516N     | 
|POLY 3             |     P=0.516N     P=0.457N     P=0.337      P=0.449N    |P=0.367      P=0.261N     P=0.134N     P=0.526      | 
|POLY 1.5           |     P=0.522N     P=0.441N     P=0.318      P=0.442N    |P=0.334      P=0.240N     P=0.132N     P=0.503      | 
|POLY 6             |     P=0.510N     P=0.506N     P=0.344      P=0.470N    |P=0.395      P=0.284N     P=0.141N     P=0.543      | 
|LOGISTIC REGRESSION|     P=0.528      P=0.528N     P=0.293      P=0.484N    |P=0.296      P=0.215N     P=0.127N     P=0.461      | 
|COCH-ARM / FISHERS |     P=0.527N     P=0.445N     P=0.290      P=0.445N    |P=0.277      P=0.206N     P=0.134N     P=0.459      | 
|ORDER RESTRICTED   |     P=0.507N     (e)          (e)          (e)         |P=0.297      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |1/49 (2%)    3/49 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.47      0/43.80      0/43.46      0/43.44     |1/44.06      3/43.88      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         6.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/36 (0%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |644          636          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.074N     P=0.299      P=0.520N     P=0.482N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.074N     P=0.304      P=0.504N     P=0.487N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.074N     P=0.303      P=0.500N     P=0.490N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.074N     P=0.305      P=0.510N     P=0.485N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.082N     P=0.315      P=0.488N     P=0.550N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.076N     P=0.309      P=0.495N     P=0.495N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.104N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/48 (33%)  15/50 (30%)  20/49 (41%)  15/50 (30%) |24/49 (49%)  21/49 (43%)  17/50 (34%)  25/50 (50%)  | 
|POLY-3 RATE (b)    |     16/43.05     15/44.42     20/45.67     15/44.68    |24/46.41     21/44.57     17/46.64     25/48.71     | 
|POLY-3 PERCENT (g) |     37.2%        33.8%        43.8%        33.6%       |51.7%        47.1%        36.5%        51.3%        | 
|TERMINAL (d)       |     13/36 (36%)  11/27 (41%)  12/31 (39%)  8/28 (29%)  |16/36 (44%)  16/36 (44%)  9/33 (27%)   20/41 (49%)  | 
|FIRST INCIDENCE    |     630          652          561          651         |511          626          511          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.375      P=0.351      P=0.166      P=0.423     |P=0.452N     P=0.373N     P=0.212N     P=0.443N     | 
|POLY 3             |     P=0.516N     P=0.457N     P=0.337      P=0.449N    |P=0.527N     P=0.409N     P=0.099N     P=0.566N     | 
|POLY 1.5           |     P=0.522N     P=0.441N     P=0.318      P=0.442N    |P=0.521      P=0.386N     P=0.095N     P=0.578      | 
|POLY 6             |     P=0.510N     P=0.506N     P=0.344      P=0.470N    |P=0.515N     P=0.430N     P=0.109N     P=0.560N     | 
|LOGISTIC REGRESSION|     P=0.528      P=0.528N     P=0.293      P=0.484N    |P=0.477      P=0.355N     P=0.089N     P=0.533      | 
|COCH-ARM / FISHERS |     P=0.527N     P=0.445N     P=0.290      P=0.445N    |P=0.463      P=0.343N     P=0.095N     P=0.540      | 
|ORDER RESTRICTED   |     P=0.507N     (e)          (e)          (e)         |P=0.355N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.72      2/43.80      0/43.73      2/43.44     |1/44.75      0/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         4.6%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    2/27 (7%)    0/31 (0%)    2/28 (7%)   |1/37 (3%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.307      P=0.177      (e)          P=0.185     |P=0.352N     P=0.505N     P=0.523N     P=0.480N     | 
|POLY 3             |     P=0.345      P=0.237      (e)          P=0.236     |P=0.365N     P=0.505N     P=0.507N     P=0.490N     | 
|POLY 1.5           |     P=0.347      P=0.239      (e)          P=0.237     |P=0.364N     P=0.503N     P=0.504N     P=0.494N     | 
|POLY 6             |     P=0.338      P=0.230      (e)          P=0.230     |P=0.366N     P=0.506N     P=0.512N     P=0.487N     | 
|LOGISTIC REGRESSION|     (e)          P=0.177      (e)          P=0.185     |P=0.352N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.347      P=0.247      (e)          P=0.247     |P=0.363N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.115      (e)          (e)          (e)         |P=0.111N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.72      2/43.80      0/43.73      2/43.44     |3/44.75      0/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         4.6%         0.0%         4.6%        |6.7%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/36 (3%)    2/27 (7%)    0/31 (0%)    2/28 (7%)   |3/37 (8%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.489      P=0.400      P=0.530N     P=0.412     |P=0.086N     P=0.126N     P=0.142N     P=0.104N     | 
|POLY 3             |     P=0.533      P=0.501      P=0.500N     P=0.498     |P=0.084N     P=0.123N     P=0.125N     P=0.110N     | 
|POLY 1.5           |     P=0.535      P=0.503      P=0.500N     P=0.500     |P=0.085N     P=0.122N     P=0.122N     P=0.113N     | 
|POLY 6             |     P=0.528      P=0.490      P=0.503N     P=0.489     |P=0.083N     P=0.124N     P=0.130N     P=0.107N     | 
|LOGISTIC REGRESSION|     P=0.489      P=0.400      (e)          P=0.412     |P=0.086N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.535      P=0.500      P=0.500N     P=0.500     |P=0.091N     P=0.121N     P=0.121N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.410      (e)          (e)          (e)         |P=0.006N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    1/50 (2%)    3/50 (6%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/44.15      4/43.99      1/43.73      3/43.48     |3/44.75      0/43.69      0/43.24      1/47.34      | 
|POLY-3 PERCENT (g) |     11.3%        9.1%         2.3%         6.9%        |6.7%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     3/36 (8%)    2/27 (7%)    1/31 (3%)    2/28 (7%)   |3/37 (8%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     636          695          729 (T)      718         |729 (T)      ---          ---          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.270N     P=0.624N     P=0.137N     P=0.470N    |P=0.322N     P=0.126N     P=0.142N     P=0.269N     | 
|POLY 3             |     P=0.224N     P=0.502N     P=0.103N     P=0.364N    |P=0.337N     P=0.123N     P=0.125N     P=0.285N     | 
|POLY 1.5           |     P=0.223N     P=0.496N     P=0.102N     P=0.358N    |P=0.340N     P=0.122N     P=0.122N     P=0.293N     | 
|POLY 6             |     P=0.227N     P=0.524N     P=0.108N     P=0.381N    |P=0.335N     P=0.124N     P=0.130N     P=0.278N     | 
|LOGISTIC REGRESSION|     P=0.227N     P=0.507N     P=0.103N     P=0.367N    |P=0.338N     (e)          (e)          P=0.300N     | 
|COCH-ARM / FISHERS |     P=0.220N     P=0.500N     P=0.102N     P=0.357N    |P=0.347N     P=0.121N     P=0.121N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.177N     (e)          (e)          (e)         |P=0.033N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   10/50 (20%)  5/50 (10%)   8/50 (16%)  |4/50 (8%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     9/43.97      10/45.25     5/44.26      8/44.06     |4/45.12      1/43.75      1/43.24      1/47.00      | 
|POLY-3 PERCENT (g) |     20.5%        22.1%        11.3%        18.2%       |8.9%         2.3%         2.3%         2.1%         | 
|TERMINAL (d)       |     7/36 (19%)   6/27 (22%)   3/31 (10%)   5/28 (18%)  |3/37 (8%)    0/36 (0%)    1/33 (3%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     695          555          607          651         |623          714          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.377N     P=0.313      P=0.274N     P=0.539     |P=0.173N     P=0.190N     P=0.213N     P=0.152N     | 
|POLY 3             |     P=0.300N     P=0.528      P=0.187N     P=0.498N    |P=0.175N     P=0.188N     P=0.191N     P=0.167N     | 
|POLY 1.5           |     P=0.297N     P=0.524      P=0.189N     P=0.495N    |P=0.180N     P=0.185N     P=0.186N     P=0.171N     | 
|POLY 6             |     P=0.306N     P=0.513      P=0.192N     P=0.514N    |P=0.172N     P=0.191N     P=0.202N     P=0.163N     | 
|LOGISTIC REGRESSION|     P=0.298N     P=0.504      P=0.196N     P=0.524N    |P=0.176N     P=0.184N     P=0.188N     P=0.173N     | 
|COCH-ARM / FISHERS |     P=0.294N     P=0.500      P=0.194N     P=0.500N    |P=0.188N     P=0.181N     P=0.181N     P=0.181N     | 
|ORDER RESTRICTED   |     P=0.335N     (e)          (e)          (e)         |P=0.066N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  12/50 (24%)  6/50 (12%)   8/50 (16%)  |4/50 (8%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     10/44.83     12/45.53     6/45.23      8/44.06     |4/45.12      2/43.76      1/43.24      2/47.23      | 
|POLY-3 PERCENT (g) |     22.3%        26.4%        13.3%        18.2%       |8.9%         4.6%         2.3%         4.2%         | 
|TERMINAL (d)       |     7/36 (19%)   7/27 (26%)   3/31 (10%)   5/28 (18%)  |3/37 (8%)    0/36 (0%)    1/33 (3%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     381          555          209          651         |623          714          729 (T)      670          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.242N     P=0.238      P=0.289N     P=0.562N    |P=0.267N     P=0.351N     P=0.213N     P=0.294N     | 
|POLY 3             |     P=0.180N     P=0.420      P=0.198N     P=0.412N    |P=0.277N     P=0.351N     P=0.191N     P=0.316N     | 
|POLY 1.5           |     P=0.176N     P=0.419      P=0.199N     P=0.404N    |P=0.283N     P=0.347N     P=0.186N     P=0.324N     | 
|POLY 6             |     P=0.188N     P=0.404      P=0.205N     P=0.431N    |P=0.273N     P=0.356N     P=0.202N     P=0.310N     | 
|LOGISTIC REGRESSION|     P=0.170N     P=0.401      P=0.205N     P=0.397N    |P=0.277N     P=0.346N     P=0.188N     P=0.339N     | 
|COCH-ARM / FISHERS |     P=0.172N     P=0.405      P=0.207N     P=0.398N    |P=0.293N     P=0.339N     P=0.181N     P=0.339N     | 
|ORDER RESTRICTED   |     P=0.243N     (e)          (e)          (e)         |P=0.168N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.58      2/44.08      0/43.73      0/43.44     |0/44.75      1/43.70      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     2.2%         4.5%         0.0%         0.0%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    1/27 (4%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     381          652          ---          ---         |---          727          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.131N     P=0.470      P=0.504N     P=0.500N    |P=0.415N     P=0.495      (e)          (e)          | 
|POLY 3             |     P=0.126N     P=0.496      P=0.504N     P=0.505N    |P=0.431N     P=0.495      (e)          (e)          | 
|POLY 1.5           |     P=0.125N     P=0.500      P=0.502N     P=0.502N    |P=0.428N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.129N     P=0.486      P=0.508N     P=0.511N    |P=0.434N     P=0.494      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.111N     P=0.334      P=0.358N     (e)         |P=0.414N     P=0.492      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.124N     P=0.500      P=0.500N     P=0.500N    |P=0.423N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.170N     (e)          (e)          (e)         |P=0.367N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.58      2/44.08      1/44.71      0/43.44     |0/44.75      1/43.70      0/43.24      1/47.23      | 
|POLY-3 PERCENT (g) |     2.2%         4.5%         2.2%         0.0%        |0.0%         2.3%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    1/27 (4%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     381          652          209          ---         |---          727          ---          670          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.203N     P=0.470      P=0.758      P=0.500N    |P=0.498      P=0.495      (e)          P=0.519      | 
|POLY 3             |     P=0.198N     P=0.496      P=0.760N     P=0.505N    |P=0.489      P=0.495      (e)          P=0.511      | 
|POLY 1.5           |     P=0.196N     P=0.500      P=0.759N     P=0.502N    |P=0.485      P=0.497      (e)          P=0.507      | 
|POLY 6             |     P=0.203N     P=0.486      P=0.758      P=0.511N    |P=0.494      P=0.494      (e)          P=0.515      | 
|LOGISTIC REGRESSION|     P=0.161N     P=0.334      (e)          (e)         |P=0.480      P=0.492      (e)          P=0.471      | 
|COCH-ARM / FISHERS |     P=0.193N     P=0.500      P=0.753N     P=0.500N    |P=0.478      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.228N     (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/44.15      2/43.99      1/43.73      1/43.48     |0/44.75      0/43.69      0/43.24      1/47.34      | 
|POLY-3 PERCENT (g) |     9.1%         4.6%         2.3%         2.3%        |0.0%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     2/36 (6%)    0/27 (0%)    1/31 (3%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     636          695          729 (T)      718         |---          ---          ---          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.156N     P=0.418N     P=0.220N     P=0.238N    |P=0.205      (e)          (e)          P=0.527      | 
|POLY 3             |     P=0.132N     P=0.338N     P=0.181N     P=0.183N    |P=0.195      (e)          (e)          P=0.511      | 
|POLY 1.5           |     P=0.132N     P=0.334N     P=0.180N     P=0.180N    |P=0.191      (e)          (e)          P=0.507      | 
|POLY 6             |     P=0.133N     P=0.354N     P=0.188N     P=0.192N    |P=0.199      (e)          (e)          P=0.516      | 
|LOGISTIC REGRESSION|     P=0.132N     P=0.335N     P=0.179N     P=0.180N    |P=0.145      (e)          (e)          P=0.438      | 
|COCH-ARM / FISHERS |     P=0.130N     P=0.339N     P=0.181N     P=0.181N    |P=0.185      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.098N     (e)          (e)          (e)         |P=0.131      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Trichoepithelioma                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.72      0/43.80      0/43.73      0/43.44     |2/44.75      0/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |2/37 (5%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381N     P=0.557N     P=0.530N     P=0.550N    |P=0.167N     P=0.244N     P=0.264N     P=0.216N     | 
|POLY 3             |     P=0.363N     P=0.500N     P=0.500N     P=0.501N    |P=0.169N     P=0.242N     P=0.245N     P=0.226N     | 
|POLY 1.5           |     P=0.365N     P=0.498N     P=0.500N     P=0.500N    |P=0.170N     P=0.241N     P=0.241N     P=0.230N     | 
|POLY 6             |     P=0.357N     P=0.506N     P=0.503N     P=0.506N    |P=0.169N     P=0.244N     P=0.251N     P=0.223N     | 
|LOGISTIC REGRESSION|     P=0.381N     (e)          (e)          (e)         |P=0.167N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.363N     P=0.500N     P=0.500N     P=0.500N    |P=0.173N     P=0.247N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.121N     (e)          (e)          (e)         |P=0.026N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  49/50 (98%)  44/50 (88%)  45/50 (90%) |                                                    | 
|POLY-3 RATE (b)    |     45/47.98     49/49.46     44/47.14     45/48.49    |                                                    | 
|POLY-3 PERCENT (g) |     93.8%        99.1%        93.3%        92.8%       |                                                    | 
|TERMINAL (d)       |     34/36 (94%)  27/27 (100%) 30/31 (97%)  27/28 (96%) |                                                    | 
|FIRST INCIDENCE    |     469          542          561          443         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.383      P=0.018 *    P=0.282      P=0.101     |                                                    | 
|POLY 3             |     P=0.198N     P=0.164      P=0.644N     P=0.593N    |                                                    | 
|POLY 1.5           |     P=0.196N     P=0.137      P=0.592N     P=0.590N    |                                                    | 
|POLY 6             |     P=0.239N     P=0.186      P=0.671      P=0.639N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.208N     P=0.215      P=0.391N     P=0.576N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.229N     P=0.102      P=0.500N     P=0.630N    |                                                    | 
|ORDER RESTRICTED   |     P=0.285N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/47 (19%)   9/44 (20%)   6/43 (14%)   9/47 (19%)  |12/47 (26%)  9/47 (19%)   11/43 (26%)  9/46 (20%)   | 
|POLY-3 RATE (b)    |     9/42.76      9/40.47      6/40.05      9/41.77     |12/42.92     9/42.52      11/38.90     9/43.71      | 
|POLY-3 PERCENT (g) |     21.1%        22.2%        15.0%        21.6%       |28.0%        21.2%        28.3%        20.6%        | 
|TERMINAL (d)       |     7/36 (19%)   7/27 (26%)   4/31 (13%)   8/28 (29%)  |10/36 (28%)  6/36 (17%)   11/32 (34%)  9/40 (23%)   | 
|FIRST INCIDENCE    |     636          619          660          718         |661          644          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.506      P=0.388      P=0.383N     P=0.395     |P=0.293N     P=0.326N     P=0.563      P=0.223N     | 
|POLY 3             |     P=0.485N     P=0.553      P=0.334N     P=0.583     |P=0.368N     P=0.317N     P=0.585      P=0.292N     | 
|POLY 1.5           |     P=0.477N     P=0.554      P=0.343N     P=0.595     |P=0.384N     P=0.317N     P=0.591      P=0.306N     | 
|POLY 6             |     P=0.503N     P=0.539      P=0.329N     P=0.553     |P=0.359N     P=0.312N     P=0.568      P=0.281N     | 
|LOGISTIC REGRESSION|     P=0.486N     P=0.547      P=0.336N     P=0.548     |P=0.340N     P=0.324N     P=0.557      P=0.265N     | 
|COCH-ARM / FISHERS |     P=0.466N     P=0.542      P=0.354N     P=0.603N    |P=0.418N     P=0.311N     P=0.593      P=0.330N     | 
|ORDER RESTRICTED   |     P=0.550N     (e)          (e)          (e)         |P=0.331N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/47 (4%)    2/44 (5%)    0/43 (0%)    1/47 (2%)   |1/47 (2%)    3/47 (6%)    1/43 (2%)    3/46 (7%)    | 
|POLY-3 RATE (b)    |     2/42.29      2/39.82      0/39.66      1/41.73     |1/42.66      3/42.30      1/39.38      3/43.71      | 
|POLY-3 PERCENT (g) |     4.7%         5.0%         0.0%         2.4%        |2.3%         7.1%         2.5%         6.9%         | 
|TERMINAL (d)       |     2/36 (6%)    2/27 (7%)    0/31 (0%)    1/28 (4%)   |1/36 (3%)    2/36 (6%)    0/32 (0%)    3/40 (8%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |729 (T)      626          587          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292N     P=0.588      P=0.272N     P=0.588N    |P=0.431      P=0.309      P=0.747      P=0.343      | 
|POLY 3             |     P=0.254N     P=0.673      P=0.251N     P=0.505N    |P=0.394      P=0.302      P=0.743      P=0.314      | 
|POLY 1.5           |     P=0.254N     P=0.674      P=0.254N     P=0.501N    |P=0.387      P=0.302      P=0.742      P=0.308      | 
|POLY 6             |     P=0.253N     P=0.666      P=0.250N     P=0.513N    |P=0.400      P=0.303      P=0.742      P=0.320      | 
|LOGISTIC REGRESSION|     P=0.292N     P=0.588      (e)          P=0.588N    |P=0.369      P=0.302      P=0.740      P=0.343      | 
|COCH-ARM / FISHERS |     P=0.254N     P=0.666      P=0.270N     P=0.500N    |P=0.374      P=0.308      P=0.730      P=0.300      | 
|ORDER RESTRICTED   |     P=0.259N     (e)          (e)          (e)         |P=0.254      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/47 (23%)  11/44 (25%)  6/43 (14%)   10/47 (21%) |13/47 (28%)  11/47 (23%)  12/43 (28%)  12/46 (26%)  | 
|POLY-3 RATE (b)    |     11/42.76     11/40.47     6/40.05      10/41.77    |13/42.92     11/42.89     12/39.38     12/43.71     | 
|POLY-3 PERCENT (g) |     25.7%        27.2%        15.0%        23.9%       |30.3%        25.7%        30.5%        27.5%        | 
|TERMINAL (d)       |     9/36 (25%)   9/27 (33%)   4/31 (13%)   9/28 (32%)  |11/36 (31%)  7/36 (19%)   11/32 (34%)  12/40 (30%)  | 
|FIRST INCIDENCE    |     636          619          660          718         |661          626          587          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.453N     P=0.342      P=0.221N     P=0.461     |P=0.423N     P=0.420N     P=0.555      P=0.381N     | 
|POLY 3             |     P=0.339N     P=0.539      P=0.174N     P=0.524N    |P=0.526N     P=0.406N     P=0.588      P=0.479N     | 
|POLY 1.5           |     P=0.332N     P=0.540      P=0.182N     P=0.509N    |P=0.541N     P=0.411N     P=0.588      P=0.495N     | 
|POLY 6             |     P=0.354N     P=0.523      P=0.169N     P=0.559N    |P=0.521N     P=0.394N     P=0.579      P=0.465N     | 
|LOGISTIC REGRESSION|     P=0.344N     P=0.527      P=0.175N     P=0.577N    |P=0.500N     P=0.424N     P=0.570      P=0.442N     | 
|COCH-ARM / FISHERS |     P=0.323N     P=0.526      P=0.191N     P=0.500N    |P=0.506      P=0.407N     P=0.582      P=0.525N     | 
|ORDER RESTRICTED   |     P=0.355N     (e)          (e)          (e)         |P=0.598N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    0/44 (0%)    0/43 (0%)    2/47 (4%)   |0/47 (0%)    0/47 (0%)    0/43 (0%)    2/46 (4%)    | 
|POLY-3 RATE (b)    |     1/42.38      0/39.82      0/39.66      2/41.73     |0/42.66      0/41.93      0/38.90      2/44.12      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         4.8%        |0.0%         0.0%         0.0%         4.5%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    2/28 (7%)   |0/36 (0%)    0/36 (0%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     705          ---          ---          729 (T)     |---          ---          ---          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.176      P=0.529N     P=0.523N     P=0.422     |P=0.052      (e)          (e)          P=0.255      | 
|POLY 3             |     P=0.206      P=0.512N     P=0.513N     P=0.495     |P=0.044 *    (e)          (e)          P=0.245      | 
|POLY 1.5           |     P=0.206      P=0.512N     P=0.515N     P=0.498     |P=0.043 *    (e)          (e)          P=0.240      | 
|POLY 6             |     P=0.205      P=0.517N     P=0.512N     P=0.485     |P=0.045 *    (e)          (e)          P=0.250      | 
|LOGISTIC REGRESSION|     P=0.196      P=0.512N     P=0.517N     P=0.478     |P=0.033 *    (e)          (e)          P=0.200      | 
|COCH-ARM / FISHERS |     P=0.207      P=0.516N     P=0.522N     P=0.500     |P=0.042 *    (e)          (e)          P=0.242      | 
|ORDER RESTRICTED   |     P=0.130      (e)          (e)          (e)         |P=0.032 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/44 (0%)    0/43 (0%)    4/47 (9%)   |1/47 (2%)    0/47 (0%)    1/43 (2%)    2/46 (4%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/39.82      0/39.66      4/41.73     |1/42.66      0/41.93      1/39.01      2/43.71      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         9.6%        |2.3%         0.0%         2.6%         4.6%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    4/28 (14%)  |1/36 (3%)    0/36 (0%)    0/32 (0%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |729 (T)      ---          703          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   (e)          (e)          P=0.035 *   |P=0.219      P=0.500N     P=0.732      P=0.537      | 
|POLY 3             |     P=0.003 **   (e)          (e)          P=0.058     |P=0.203      P=0.503N     P=0.741      P=0.508      | 
|POLY 1.5           |     P=0.003 **   (e)          (e)          P=0.059     |P=0.198      P=0.503N     P=0.741      P=0.503      | 
|POLY 6             |     P=0.003 **   (e)          (e)          P=0.055     |P=0.207      P=0.504N     P=0.739      P=0.514      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.035 *   |P=0.204      (e)          P=0.742      P=0.537      | 
|COCH-ARM / FISHERS |     P=0.003 **   (e)          (e)          P=0.058     |P=0.187      P=0.500N     P=0.730      P=0.492      | 
|ORDER RESTRICTED   |     P=0.002 **   (e)          (e)          (e)         |P=0.236      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    0/44 (0%)    0/43 (0%)    6/47 (13%)  |1/47 (2%)    0/47 (0%)    1/43 (2%)    4/46 (9%)    | 
|POLY-3 RATE (b)    |     1/42.38      0/39.82      0/39.66      6/41.73     |1/42.66      0/41.93      1/39.01      4/44.12      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         14.4%       |2.3%         0.0%         2.6%         9.1%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    6/28 (21%)  |1/36 (3%)    0/36 (0%)    0/32 (0%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     705          ---          ---          729 (T)     |729 (T)      ---          703          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.529N     P=0.523N     P=0.028 *   |P=0.034 *    P=0.500N     P=0.732      P=0.212      | 
|POLY 3             |     P=0.002 **   P=0.512N     P=0.513N     P=0.052     |P=0.026 *    P=0.503N     P=0.741      P=0.189      | 
|POLY 1.5           |     P=0.002 **   P=0.512N     P=0.515N     P=0.055     |P=0.024 *    P=0.503N     P=0.741      P=0.182      | 
|POLY 6             |     P=0.002 **   P=0.517N     P=0.512N     P=0.048 *   |P=0.027 *    P=0.504N     P=0.739      P=0.196      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.512N     P=0.517N     P=0.037 *   |P=0.024 *    (e)          P=0.742      P=0.172      | 
|COCH-ARM / FISHERS |     P=0.002 **   P=0.516N     P=0.522N     P=0.055     |P=0.023 *    P=0.500N     P=0.730      P=0.174      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.029 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |9/50 (18%)   8/50 (16%)   9/50 (18%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |                                                        |9/45.06      8/44.03      9/45.03      7/47.57      | 
|POLY-3 PERCENT (g) |                                                        |20.0%        18.2%        20.0%        14.7%        | 
|TERMINAL (d)       |                                                        |8/37 (22%)   7/36 (19%)   4/33 (12%)   5/41 (12%)   | 
|FIRST INCIDENCE    |                                                        |644          636          514          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.303N     P=0.524N     P=0.518      P=0.312N     | 
|POLY 3             |                                                        |P=0.318N     P=0.521N     P=0.603      P=0.347N     | 
|POLY 1.5           |                                                        |P=0.341N     P=0.514N     P=0.602N     P=0.365N     | 
|POLY 6             |                                                        |P=0.297N     P=0.527N     P=0.596      P=0.331N     | 
|LOGISTIC REGRESSION|                                                        |P=0.358N     P=0.527N     P=0.599      P=0.357N     | 
|COCH-ARM / FISHERS |                                                        |P=0.380N     P=0.500N     P=0.602N     P=0.393N     | 
|ORDER RESTRICTED   |                                                        |P=0.403N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |10/50 (20%)  8/50 (16%)   9/50 (18%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |                                                        |10/45.06     8/44.03      9/45.03      7/47.57      | 
|POLY-3 PERCENT (g) |                                                        |22.2%        18.2%        20.0%        14.7%        | 
|TERMINAL (d)       |                                                        |9/37 (24%)   7/36 (19%)   4/33 (12%)   5/41 (12%)   | 
|FIRST INCIDENCE    |                                                        |644          636          514          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.245N     P=0.422N     P=0.585N     P=0.226N     | 
|POLY 3             |                                                        |P=0.255N     P=0.417N     P=0.501N     P=0.255N     | 
|POLY 1.5           |                                                        |P=0.277N     P=0.411N     P=0.499N     P=0.271N     | 
|POLY 6             |                                                        |P=0.236N     P=0.423N     P=0.508N     P=0.239N     | 
|LOGISTIC REGRESSION|                                                        |P=0.291N     P=0.423N     P=0.507N     P=0.262N     | 
|COCH-ARM / FISHERS |                                                        |P=0.314N     P=0.398N     P=0.500N     P=0.298N     | 
|ORDER RESTRICTED   |                                                        |P=0.280N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.39      1/43.80      0/43.73      0/43.44     |0/44.75      2/44.02      1/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         0.0%         0.0%        |0.0%         4.5%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    1/27 (4%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    1/33 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     503          729 (T)      ---          ---         |---          639          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.215N     P=0.736      P=0.496N     P=0.500N    |P=0.316N     P=0.234      P=0.477      (e)          | 
|POLY 3             |     P=0.205N     P=0.758      P=0.503N     P=0.504N    |P=0.324N     P=0.233      P=0.493      (e)          | 
|POLY 1.5           |     P=0.205N     P=0.760N     P=0.502N     P=0.502N    |P=0.328N     P=0.234      P=0.496      (e)          | 
|POLY 6             |     P=0.206N     P=0.750      P=0.507N     P=0.510N    |P=0.321N     P=0.233      P=0.488      (e)          | 
|LOGISTIC REGRESSION|     P=0.195N     P=0.710      P=0.450N     P=0.597N    |P=0.330N     P=0.239      P=0.477      (e)          | 
|COCH-ARM / FISHERS |     P=0.203N     P=0.753N     P=0.500N     P=0.500N    |P=0.333N     P=0.247      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.253N     (e)          (e)          (e)         |P=0.309N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  21/50 (42%)  16/50 (32%)  23/50 (46%) |11/50 (22%)  9/50 (18%)   13/50 (26%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     13/45.60     21/46.69     16/45.67     23/47.49    |11/45.75     9/44.07      13/44.89     9/47.79      | 
|POLY-3 PERCENT (g) |     28.5%        45.0%        35.0%        48.4%       |24.0%        20.4%        29.0%        18.8%        | 
|TERMINAL (d)       |     8/36 (22%)   8/27 (30%)   8/31 (26%)   10/28 (36%) |7/37 (19%)   8/36 (22%)   7/33 (21%)   6/41 (15%)   | 
|FIRST INCIDENCE    |     545          574          561          465         |594          623          615          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.084      P=0.037 *    P=0.255      P=0.020 *   |P=0.387N     P=0.430N     P=0.318      P=0.325N     | 
|POLY 3             |     P=0.111      P=0.074      P=0.328      P=0.036 *   |P=0.408N     P=0.437N     P=0.385      P=0.359N     | 
|POLY 1.5           |     P=0.106      P=0.075      P=0.329      P=0.034 *   |P=0.436N     P=0.424N     P=0.395      P=0.375N     | 
|POLY 6             |     P=0.111      P=0.067      P=0.315      P=0.035 *   |P=0.381N     P=0.452N     P=0.370      P=0.345N     | 
|LOGISTIC REGRESSION|     P=0.098      P=0.069      P=0.330      P=0.029 *   |P=0.452N     P=0.421N     P=0.396      P=0.399N     | 
|COCH-ARM / FISHERS |     P=0.097      P=0.069      P=0.330      P=0.030 *   |P=0.484N     P=0.402N     P=0.408      P=0.402N     | 
|ORDER RESTRICTED   |     P=0.031 *    (e)          (e)          (e)         |P=0.404N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.72      1/44.06      2/44.36      2/43.44     |0/44.75      0/43.69      1/43.76      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         4.5%         4.6%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    2/28 (7%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          660          607          729 (T)     |---          ---          573          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.157      P=0.500      P=0.237      P=0.185     |P=0.647      (e)          P=0.504      (e)          | 
|POLY 3             |     P=0.164      P=0.502      P=0.240      P=0.236     |P=0.667      (e)          P=0.496      (e)          | 
|POLY 1.5           |     P=0.166      P=0.503      P=0.239      P=0.237     |P=0.656      (e)          P=0.498      (e)          | 
|POLY 6             |     P=0.158      P=0.496      P=0.239      P=0.230     |P=0.677      (e)          P=0.491      (e)          | 
|LOGISTIC REGRESSION|     P=0.166      P=0.484      P=0.239      P=0.185     |P=0.571      (e)          P=0.513      (e)          | 
|COCH-ARM / FISHERS |     P=0.166      P=0.500      P=0.247      P=0.247     |P=0.637      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.153      (e)          (e)          (e)         |P=0.377      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.72      1/44.06      2/44.36      2/43.44     |0/44.75      0/43.69      1/43.76      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         4.5%         4.6%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    2/28 (7%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          660          607          729 (T)     |---          ---          573          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.157      P=0.500      P=0.237      P=0.185     |P=0.647      (e)          P=0.504      (e)          | 
|POLY 3             |     P=0.164      P=0.502      P=0.240      P=0.236     |P=0.667      (e)          P=0.496      (e)          | 
|POLY 1.5           |     P=0.166      P=0.503      P=0.239      P=0.237     |P=0.656      (e)          P=0.498      (e)          | 
|POLY 6             |     P=0.158      P=0.496      P=0.239      P=0.230     |P=0.677      (e)          P=0.491      (e)          | 
|LOGISTIC REGRESSION|     P=0.166      P=0.484      P=0.239      P=0.185     |P=0.571      (e)          P=0.513      (e)          | 
|COCH-ARM / FISHERS |     P=0.166      P=0.500      P=0.247      P=0.247     |P=0.637      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.153      (e)          (e)          (e)         |P=0.377      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.64      0/43.80      0/43.73      1/43.44     |0/44.75      1/44.23      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     6.7%         0.0%         0.0%         2.3%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    1/28 (4%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     469          ---          ---          729 (T)     |---          563          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.377N     P=0.141N     P=0.138N     P=0.365N    |P=0.415N     P=0.496      (e)          (e)          | 
|POLY 3             |     P=0.344N     P=0.122N     P=0.122N     P=0.315N    |P=0.429N     P=0.498      (e)          (e)          | 
|POLY 1.5           |     P=0.347N     P=0.119N     P=0.121N     P=0.309N    |P=0.427N     P=0.498      (e)          (e)          | 
|POLY 6             |     P=0.336N     P=0.129N     P=0.127N     P=0.327N    |P=0.432N     P=0.498      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.344N     P=0.150N     P=0.115N     P=0.315N    |P=0.509N     P=0.556      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.347N     P=0.121N     P=0.121N     P=0.309N    |P=0.423N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.041N*    (e)          (e)          (e)         |P=0.370N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.64      0/43.80      0/43.73      1/43.44     |0/44.75      1/44.23      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     6.7%         0.0%         0.0%         2.3%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    1/28 (4%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     469          ---          ---          729 (T)     |---          563          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.377N     P=0.141N     P=0.138N     P=0.365N    |P=0.415N     P=0.496      (e)          (e)          | 
|POLY 3             |     P=0.344N     P=0.122N     P=0.122N     P=0.315N    |P=0.429N     P=0.498      (e)          (e)          | 
|POLY 1.5           |     P=0.347N     P=0.119N     P=0.121N     P=0.309N    |P=0.427N     P=0.498      (e)          (e)          | 
|POLY 6             |     P=0.336N     P=0.129N     P=0.127N     P=0.327N    |P=0.432N     P=0.498      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.344N     P=0.150N     P=0.115N     P=0.315N    |P=0.509N     P=0.556      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.347N     P=0.121N     P=0.121N     P=0.309N    |P=0.423N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.041N*    (e)          (e)          (e)         |P=0.370N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/50 (96%)  49/50 (98%)  47/50 (94%)  47/50 (94%) |46/50 (92%)  42/50 (84%)  44/50 (88%)  47/50 (94%)  | 
|POLY-3 RATE (b)    |     48/48.34     49/49.46     47/48.09     47/48.82    |46/48.80     42/47.38     44/48.83     47/49.41     | 
|POLY-3 PERCENT (g) |     99.3%        99.1%        97.7%        96.3%       |94.3%        88.7%        90.1%        95.1%        | 
|TERMINAL (d)       |     36/36 (100%) 27/27 (100%) 31/31 (100%) 27/28 (96%) |35/37 (95%)  33/36 (92%)  29/33 (88%)  39/41 (95%)  | 
|FIRST INCIDENCE    |     469          542          561          443         |423          365          511          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.337      P=0.048 *    P=0.270      P=0.129     |P=0.408N     P=0.360N     P=0.408      P=0.303N     | 
|POLY 3             |     P=0.128N     P=0.955N     P=0.608N     P=0.346N    |P=0.319      P=0.248N     P=0.342N     P=0.609      | 
|POLY 1.5           |     P=0.162N     P=0.826      P=0.580N     P=0.384N    |P=0.261      P=0.208N     P=0.356N     P=0.567      | 
|POLY 6             |     P=0.126N     P=1.000N     P=0.707N     P=0.386N    |P=0.402      P=0.323N     P=0.326N     P=0.650      | 
|LOGISTIC REGRESSION|     P=0.210N     P=0.355N     P=0.240N     P=0.346N    |P=0.313      P=0.216N     P=0.396N     P=0.641      | 
|COCH-ARM / FISHERS |     P=0.249N     P=0.500      P=0.500N     P=0.500N    |P=0.202      P=0.178N     P=0.370N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.135N     (e)          (e)          (e)         |P=0.334      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  32/50 (64%)  24/50 (48%)  32/50 (64%) |21/50 (42%)  22/50 (44%)  19/50 (38%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     27/48.71     32/47.98     24/48.25     32/48.14    |21/47.47     22/46.55     19/47.04     22/48.35     | 
|POLY-3 PERCENT (g) |     55.4%        66.7%        49.7%        66.5%       |44.2%        47.3%        40.4%        45.5%        | 
|TERMINAL (d)       |     16/36 (44%)  14/27 (52%)  11/31 (36%)  16/28 (57%) |14/37 (38%)  14/36 (39%)  8/33 (24%)   17/41 (42%)  | 
|FIRST INCIDENCE    |     381          562          209          465         |462          541          547          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.276      P=0.092      P=0.513N     P=0.098     |P=0.391N     P=0.461      P=0.551N     P=0.499N     | 
|POLY 3             |     P=0.365      P=0.175      P=0.360N     P=0.181     |P=0.497N     P=0.465      P=0.432N     P=0.533      | 
|POLY 1.5           |     P=0.375      P=0.191      P=0.350N     P=0.194     |P=0.513N     P=0.472      P=0.428N     P=0.520      | 
|POLY 6             |     P=0.347      P=0.152      P=0.382N     P=0.160     |P=0.486N     P=0.471      P=0.435N     P=0.547      | 
|LOGISTIC REGRESSION|     P=0.390      P=0.196      P=0.346N     P=0.206     |P=0.502      P=0.503      P=0.392N     P=0.480      | 
|COCH-ARM / FISHERS |     P=0.384      P=0.208      P=0.345N     P=0.208     |P=0.527      P=0.500      P=0.419N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.204      (e)          (e)          (e)         |P=0.610N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 26      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -      WATER DISINFECTION BYPRODUCTS (SODIUM 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     49/50 (98%)  50/50 (100%) 50/50 (100%) 50/50 (100%)|49/50 (98%)  48/50 (96%)  46/50 (92%)  48/50 (96%)  | 
|POLY-3 RATE (b)    |     49/49.20     50/50.00     50/50.00     50/50.00    |49/50.00     48/49.21     46/49.17     48/49.41     | 
|POLY-3 PERCENT (g) |     99.6%        100.0%       100.0%       100.0%      |98.0%        97.5%        93.6%        97.1%        | 
|TERMINAL (d)       |     36/36 (100%) 27/27 (100%) 31/31 (100%) 28/28 (100%)|36/37 (97%)  35/36 (97%)  30/33 (91%)  40/41 (98%)  | 
|FIRST INCIDENCE    |     381          542          209          443         |423          365          511          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.206      P=0.054      P=0.176      P=0.073     |P=0.149N     P=0.551      P=0.467      P=0.168N     | 
|POLY 3             |     P=0.987      P=1.000      P=1.000      P=1.000     |P=0.429N     P=0.706N     P=0.271N     P=0.652N     | 
|POLY 1.5           |     P=0.671      P=0.894      P=0.894      P=0.894     |P=0.401N     P=0.639N     P=0.237N     P=0.589N     | 
|POLY 6             |     P=1.000      P=1.000      P=1.000      P=1.000     |P=0.470N     P=0.746N     P=0.294N     P=0.716N     | 
|LOGISTIC REGRESSION|     P=0.306      P=0.995      P=0.398      P=0.764     |P=0.274N     P=0.536N     P=0.188N     P=0.444N     | 
|COCH-ARM / FISHERS |     P=0.363      P=0.500      P=0.500      P=0.500     |P=0.380N     P=0.500N     P=0.181N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.119      (e)          (e)          (e)         |P=0.359N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    

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