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TDMS Study 96010-03 Pathology Tables

NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03
Route: DOSED WATER                                                                                                Time: 13:28:43

                                                          FINAL#1/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  7775-09-9

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X|             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |                                              X           X        X     X|             
      Congestion                           |          2                          2                                   2|             
      Degeneration, Cystic, Focal          |                                                                          |             
      Hemorrhage                           |                                                                2         |             
      Hepatodiaphragmatic Nodule           |                3                                                        3|             
      Hyperplasia, Focal, Histiocytic      |          1        1  1  2  1                    3     1  1     3  3     1|             
      Hyperplasia, Focal, Regenerative     |                                                                         4|             
      Infiltration Cellular, Mixed Cell    | 2     2  2  2  2  2  2     2  1  2  2  2  2  2  2  2  2  2     2  2      |             
      Mixed Cell Focus                     |    X           X                 X                          X        X   |             
      Bile Duct, Hyperplasia               |             1           2     2  1  1  1  2  1  1        2  1     1  2  2|             
      Capsule, Cyst                        |                                                                3         |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |             2                                                            |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |       1  1     2  1           2  1              1                    1  3|             
      Hepatocyte, Centrilobular, Necrosis  |       2                                                                  |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +                       +     +  +           +                 +  +   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Fat, Necrosis, Focal                 |    2                             2  2           2                 3      |             
      Fat, Necrosis                        |                            3                                             |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 1        1           1                                      1           4|             
      Duct, Cyst, Focal                    | 1                                                                        |             
      Duct, Cyst, Focal, Multiple          |    1                 2        1              1                    2      |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |          2                                                               |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                               2                                          |             
      Epithelium, Hyperplasia              |                               2                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Focal                       |                                                                          |             
      Erosion                              |       2                                                                  |             
      Pigmentation, Focal                  |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1                                                                  |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 1                       1                                                |             
      Angiectasis                          |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                2  1     1                                                |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                        1                                 |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                          3  2                 3           3      |             
      Pigmentation, Focal                  |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | 3                                                                        |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                      1                                                   |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |             1           2                       1  1        2            |             
      Pars Distalis, Hemorrhage, Focal     |             3  3     3                    3                       3      |             
      Pars Distalis, Hyperplasia, Focal    | 3  2                    2                                                |             
      Rathke's Cleft, Cyst                 |                                                                          |             
      Rathke's Cleft, Hemorrhage           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |       2                                                                  |             
      C-Cell, Hyperplasia                  | 3  3  2  3  3     2  1  2  2  3  2  1     2  3  2  2  2     1  2  2  2  3|             
      Follicle, Mineralization, Focal      | 1              1     1  1        1  1        1  1           1  1  1  1  1|             
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |             
           Focal                           |                                                                          |             
      Follicular Cell, Hypertrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        4                                 |             
      Degeneration, Cystic                 |    3                                         3           3     3         |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic                |                3  1                             3                        |             
      Duct, Inflammation, Chronic          |                                        4                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3     2                    1                       2                     |             
      Periovarian Tissue, Cyst             |                      3                       3                           |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                            3                                             |             
      Endometrium, Hyperplasia, Cystic     |                   2                       1              2           1  3|             
                                           |__________________________________________________________________________|             
   Vagina                                  |       +                       +                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         3                                                |             
      Myeloid Cell, Hyperplasia            |                                        3                    2  2         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +              +        +  +     +  +  +  +        +  +  +  +     +  +|             
      Hyperplasia, Plasma Cell             |                                                          3               |             
      Deep Cervical, Hemorrhage            |                                                                          |             
      Deep Cervical, Hyperplasia, Lymphoid |                                        3                                 |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                     3                          3         |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               |                                                          3     3         |             
      Pancreatic, Hyperplasia, Histiocytic | 3  3              1        2  1        2  3  1        1  3  1  1     2  2|             
      Pancreatic, Pigmentation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                         3                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2                    4     2  3  4           2     2     3         |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                             4            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |       3                                                                  |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          2  2  2  3  3  2     4  4  4  2  4  3  2     4  2  2     4  2  2|             
      Ectasia                              |       3                    2                                             |             
      Fibrosis, Focal                      |                                                                          |             
      Fibrosis                             |                                                                2         |             
      Hyperplasia, Focal                   |                                           3                              |             
      Hyperplasia                          |                                              2                           |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |          4        3           3           2                          3   |             
      Thalamus, Mineralization, Focal      |                                                                          |             
      Thalamus, Necrosis, Focal            |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                    2                     |             
      Hyperplasia, Histiocytic             |       2                    2                                             |             
      Infiltration Cellular, Mixed Cell    |       2                                                                  |             
      Inflammation, Chronic, Focal         |             1                                                            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 1                                                              2         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        3                                 |             
      Cataract                             |    3                    2                                                |             
      Retinal Detachment                   |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Cornea, Necrosis, Focal              |                                                                          |             
      Retina, Degeneration                 |    4                                                                     |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Focal           |                      2                                                   |             
      Hyperplasia, Focal, Histiocytic      |                      3                                         2         |             
      Epithelium, Hyperplasia, Focal       |                                                                1         |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Inflammation, Chronic                |                                                                      2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Nephropathy                          | 1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                   3  3                                               2   |             
      Renal Tubule, Pigmentation           |       1                                                                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3|            |
                                           | 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X  X     X  X  X  X  X     X  X  X        X     X  X  X     X  X  X|     42     |
      Cholangiofibrosis                    |                                                    4                     |      1  4.0|
      Clear Cell Focus                     |                                                       X  X               |      6     |
      Congestion                           | 2                    2           2                                       |      6  2.0|
      Degeneration, Cystic, Focal          |                                  2                                       |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                   3                             2     3  2     3         |      7  2.7|
      Hyperplasia, Focal, Histiocytic      | 3        3     1  1              1  1  1        2                       1|     20  1.6|
      Hyperplasia, Focal, Regenerative     |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |    1  2  2     2  2  2  2  2     2  2  2        2  2  2  1  2     2  2  2|     39  1.9|
      Mixed Cell Focus                     |                X  X  X                 X           X              X  X   |     12     |
      Bile Duct, Hyperplasia               |    2  2  2              1     2     1  1  2  1     3  1  1     2  1     1|     29  1.5|
      Capsule, Cyst                        |                                                                          |      1  3.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               | 2              1  1        1                 3  1  2                 1   |     17  1.5|
      Hepatocyte, Centrilobular, Necrosis  |    2                                                                     |      2  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3|            |
                                           | 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |    3        4                 2           4                    2         |      5  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +  +           +  +  +        +  +     +     +  +  +            |  18        |
      Fat, Necrosis, Focal                 |          3  3           2  2           2              2     3            |     12  2.3|
      Fat, Necrosis                        |                               3                 2        2               |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Focal               | 2           2  1  1              1  1  1  1     2                    1   |     15  1.4|
      Duct, Cyst, Focal                    |                                                                          |      1  1.0|
      Duct, Cyst, Focal, Multiple          | 2  1           1                          2                          1   |     10  1.4|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |       2                                                                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                           2                              |      2  2.0|
      Epithelium, Hyperplasia              |                                           2                              |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion, Focal                       |                                           2                              |      1  2.0|
      Erosion                              |             2                                                            |      2  2.0|
      Pigmentation, Focal                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                        2              2  1               |      4  1.5|
      Thrombosis                           |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3|            |
                                           | 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Angiectasis                          |                         2     3                                          |      2  2.5|
      Cytoplasmic Alteration, Focal        |                               2                                          |      1  2.0|
      Hemorrhage                           |                                                                3         |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                   1  2  2                    1                           |      7  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                         1                    1                           |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |       2                 3              2     3  2                        |     10  2.5|
      Pigmentation, Focal                  |                                                 2                        |      1  2.0|
      Pars Distalis, Angiectasis           |                                                                         3|      1  3.0|
      Pars Distalis, Cyst                  |                                                                   2      |      2  2.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                1                                1                        |      3  1.0|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                2  3                                2  2  2        3      |     11  1.9|
      Pars Distalis, Hemorrhage, Focal     |    3                                2     3                    3         |      9  2.9|
      Pars Distalis, Hyperplasia, Focal    |       3           2                 2                                   2|      7  2.3|
      Rathke's Cleft, Cyst                 |                                                                   2      |      1  2.0|
      Rathke's Cleft, Hemorrhage           |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 3  2  2     2  1  2  3  3  2     2  2  2  3  2  2  2  3  1  2        2  3|     43  2.2|
      Follicle, Mineralization, Focal      | 1     1  1  1  1  1  1  1              1  1  1                       1   |     25  1.0|
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |            |
           Focal                           |                                              2                           |      1  2.0|
      Follicular Cell, Hypertrophy         |                                                 1                 2  1   |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3|            |
                                           | 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Cyst                                 |                                                                          |      1  4.0|
      Degeneration, Cystic                 |                                                                         3|      5  3.0|
      Hyperplasia, Cystic                  |    3                                                                     |      1  3.0|
      Inflammation, Chronic                | 3           4  3                                                         |      6  2.8|
      Duct, Inflammation, Chronic          |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                              3                           |      5  2.2|
      Periovarian Tissue, Cyst             |             3                                                     3      |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    2  1           1  2              2     1           2  1  3     2     2|     16  1.8|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +     +                                   +                 +            |   6        |
      Cyst                                 | 3     3                                                                  |      2  3.0|
      Inflammation, Chronic                | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              4                           |      2  3.5|
      Myeloid Cell, Hyperplasia            | 2              2        3                                3               |      7  2.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +  +     +  +  +  +|  36        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Deep Cervical, Hemorrhage            |       2                                                                  |      1  2.0|
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3|            |
                                           | 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Mediastinal, Congestion              |                               3                                          |      1  3.0|
      Mediastinal, Ectasia                 |          3                          3                                    |      2  3.0|
      Mediastinal, Hemorrhage              | 3        3                                3  3                           |      6  3.0|
      Mediastinal, Hyperplasia, Histiocytic|    3                                                                     |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                3                                                         |      1  3.0|
      Pancreatic, Ectasia                  |       2                                                                  |      1  2.0|
      Pancreatic, Hemorrhage               |                                     3        3     3                     |      5  3.0|
      Pancreatic, Hyperplasia, Histiocytic | 2  3  1  3           2  2     1  1  3     1  2  2  2  2  2           1  1|     31  1.8|
      Pancreatic, Pigmentation             |                                                                   2      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  +|   4        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Histiocytic             |          3                                                               |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                         3|      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |          2           2  3  2     2                    2  2        2      |     16  2.4|
      Hemorrhage                           |                               2                                          |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                                                    4                     |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                               3                                2         |      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 2  4  3  4  4  2  4  4  4  3        4  4  3  3        3     4     4     4|     37  3.1|
      Ectasia                              |                               2                                4         |      4  2.8|
      Fibrosis, Focal                      |                      2                                                   |      1  2.0|
      Fibrosis                             |                                                    3                     |      2  2.5|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3|            |
                                           | 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Hyperplasia                          | 2                 2                 3              3  3                 2|      7  2.4|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibrosis, Focal |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression, Focal                   |    2        2                                               3  2         |      9  2.7|
      Thalamus, Mineralization, Focal      |       3                                                                  |      1  3.0|
      Thalamus, Necrosis, Focal            |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |             +                                                            |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                                           2                              |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                 2        1               |      4  1.8|
      Infiltration Cellular, Mixed Cell    |             3                                                            |      2  2.5|
      Inflammation, Chronic, Focal         |       1                                                                  |      2  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |          1                                         2                     |      4  1.5|
      Alveolar Epithelium, Hyperplasia     |                               1                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3|            |
                                           | 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Cataract                             |                                                                          |      2  2.5|
      Retinal Detachment                   |                                           3                              |      1  3.0|
      Cornea, Inflammation, Chronic        |                                                                   4      |      1  4.0|
      Cornea, Necrosis, Focal              |                                                                   4      |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic, Focal           |                                                                          |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      2  2.5|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                      3   |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Nephropathy                          | 1     1  1  1  1  1  1  2  1     1  1  1  1  1  1     2     1     1  2  1|     43  1.1|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          | 2                       3                                                |      5  2.6|
      Renal Tubule, Pigmentation           |                                                          1               |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X  X  X  X  X  X   |             
      Clear Cell Focus                     | X        X                             X     X  X  X  X  X               |             
      Congestion                           |                                                    2                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                    3                     |             
      Hyperplasia, Focal, Histiocytic      | 2  1     1  2              1        1  3  3  1              1        1   |             
      Infarct, Multiple                    |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                      3                                                   |             
      Infiltration Cellular, Mixed Cell    | 2  2  2     2  1        2  2  2     2  2  2  2  2  1  2  2  2     2  2   |             
      Mixed Cell Focus                     | X                             X                          X               |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |    1  1  1     1     2     1     1  1  1        1           1  1     2   |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Necrosis, Focal          |                                                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                            3     2                                       |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |    2                                            1        2               |             
      Hepatocyte, Periportal,              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
          Vacuolization Cytoplasmic        |                                                                          |             
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                                                         3|             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |                   4                                                      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                   +                    +     +                          +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Fat, Necrosis, Focal                 |                   3                    3     3                           |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |             2           3     3                 2                        |             
      Duct, Cyst, Focal                    |                                                             1            |             
      Duct, Cyst, Focal, Multiple          |    2     2  2        1        2     2  2        1                    2   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                            2                                             |             
      Ulcer                                |                   2  3     2                                            3|             
      Epithelium, Hyperplasia              |                            2                                            3|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Ulcer                                |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dentine, Malformation                |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
   Blood Vessel                            |                                                                          |             
      Thrombosis                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                2     3                                                   |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                                                          3               |             
      Cytoplasmic Alteration, Focal        |                                        3        1                        |             
      Degeneration, Cystic, Focal          |                                                          3               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Necrosis, Focal                      |                   3                                                      |             
      Vacuolization Cytoplasmic, Focal     | 1              1              1                 2        3        2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                         1                                                |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Angiectasis           |                                                       2                  |             
      Pars Distalis, Cyst                  |                3                                                         |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                          |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |             1                    1     2     2                           |             
      Pars Distalis, Hemorrhage, Focal     |                   2           3                 3                       4|             
      Pars Distalis, Hyperplasia, Focal    |                               2        2              3                  |             
      Pars Nervosa, Hyperplasia, Atypical, |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
           Focal                           |                                                                          |             
      Rathke's Cleft, Cyst                 |          2                                                               |             
      Rathke's Cleft, Hemorrhage           |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3  2  2  3  2  1  1     2  2  3  2     2     2  2  3  3  2  2  2  2  3  1|             
      Follicle, Mineralization, Focal      | 1     1     1  1  1        1  1  1  1        1  1              1     1  1|             
      Follicular Cell, Hypertrophy         | 1                             1                             1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |          +                                                              +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    3                                                                     |             
      Hyperplasia, Cystic, Focal           |                                                                          |             
      Hyperplasia, Cystic                  |          3                                                        3      |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3                                                                     |             
      Interstitial Cell, Hyperplasia       |             2                                                            |             
      Periovarian Tissue, Cyst             |             3           3                          3              3      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      3   |             
      Inflammation, Suppurative            |                      3                                                   |             
      Endometrium, Hyperplasia, Cystic     |                1                                                         |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                      +           +                                       |             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia                          |                1                                                         |             
      Myeloid Cell, Hyperplasia            |       2              3                                                   |             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +           +  +  +        +  +  +  +  +     +           +  +     +  +  +|             
      Mediastinal, Ectasia                 |                                        3                                 |             
      Mediastinal, Hemorrhage              |                                              3              3            |             
      Mediastinal, Hyperplasia, Histiocytic| 3                                                                        |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                      3   |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic | 2           2              3  1     3  2                 3  2     2      |             
      Pancreatic, Pigmentation             |                                              1                       1   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  +  M  M  M|             
      Ectasia                              |          3                                                               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |             3                                                            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |       2  2        3  4     2  2           2     2     2     2     2      |             
      Hemorrhage                           |                      2                                                   |             
      Hyperplasia, Focal, Histiocytic      |                                                 2                    2   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 4  3  2  2  3  2  4     2  3  4  4  4  4     2  2  4  4  4  3  4  4  2  3|             
      Ectasia                              |                      2                                                   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |       1           3                 3                             3  2   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |    3                       3        2                       3        2   |             
      Hemorrhage, Focal                    |                   3              2                                       |             
      Necrosis, Focal                      |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |    +                       +                          +                  |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |    +                       +                          +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia, Histiocytic             |                      1                    2                              |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                      3                                                   |             
      Infiltration Cellular, Mixed Cell    |                                                          2               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                         2              1                                 |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   3                                                      |             
      Nasolacrimal Duct, Inflammation      |                                                                         2|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                              3        1                  |             
      Hemorrhage                           |                   3                                                      |             
      Cornea, Inflammation, Chronic        |                                                       3                  |             
      Retina, Degeneration                 |                                              3                           |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                          4               |             
      Infarct                              |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                      3                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 1  1  1  1  1  1  1     2  1  1        1     1  1  1  1  3     1  1  1  1|             
      Pelvis, Inflammation, Chronic        |                                                          3               |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                          2               |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |    2  2                             2           2  2        2     2  2   |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                                  2                                       |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X  X  X     X|     44     |
      Clear Cell Focus                     | X        X           X     X        X                       X  X  X      |     16     |
      Congestion                           |                4                                                         |      2  3.0|
      Eosinophilic Focus                   |                                                                      X   |      1     |
      Hepatodiaphragmatic Nodule           |                                  3                    3           3      |      4  3.0|
      Hyperplasia, Focal, Histiocytic      |    3     1  3           3        2                 1  1  2               |     19  1.7|
      Infarct, Multiple                    |                   3                                                      |      1  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    | 1  2  2  2  2        2  2  2     2  2     2  2  2  2  2  3  1     2     2|     38  1.9|
      Mixed Cell Focus                     |                                  X     X                    X            |      6     |
      Thrombosis                           |                   3                                                      |      1  3.0|
      Bile Duct, Cyst                      |                                                                      2   |      1  2.0|
      Bile Duct, Hyperplasia               |                3  2     3           2        2        1  3  1  1  1  3   |     24  1.5|
      Hepatocyte, Karyomegaly              |                                                          3               |      1  3.0|
      Hepatocyte, Necrosis, Focal          |                      2        1                                          |      2  1.5|
      Hepatocyte, Vacuolization            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      2  2.5|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |                      2     1     2     2     1        2  2               |     10  1.7|
      Hepatocyte, Periportal,              |                                                                          |            |
          Vacuolization Cytoplasmic        | 1                                         3                              |      2  2.0|
      Hepatocyte, Centrilobular, Necrosis  |                   4                                                      |      1  4.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                   3                                                  3   |      3  3.0|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |                               3                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +              +                 +                 +  +  +               |  10        |
      Inflammation, Chronic, Focal         |                                                          2               |      1  2.0|
      Fat, Necrosis, Focal                 |                                                    3  1                  |      5  2.6|
      Fat, Necrosis                        | 2                                2                                       |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |                                  2                    1     2        2   |      8  2.1|
      Duct, Cyst, Focal                    |                               1                                          |      2  1.0|
      Duct, Cyst, Focal, Multiple          |       1     2                                               2  2     2   |     14  1.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                3                                                         |      1  3.0|
      Erosion                              |                               2                                          |      1  2.0|
      Inflammation, Chronic                |                               3                                          |      2  2.5|
      Ulcer                                |                2              2  3                                       |      7  2.4|
      Epithelium, Hyperplasia              |                               3                          1               |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                               2                                          |      1  2.0|
      Necrosis, Focal                      |                               2                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                           +                          +   |   2        |
      Dentine, Malformation                |                                                                      3   |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                           3                              |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                   +                                                      |   1        |
      Thrombosis                           |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      2  2.5|
      Infiltration Cellular, Mixed Cell    |                                              1                           |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                1           1                                      2      |      3  1.3|
      Angiectasis                          |                                                                          |      1  3.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      2  2.0|
      Degeneration, Cystic, Focal          |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                  2                                       |      1  2.0|
      Hemorrhage                           |                                        3                                 |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                   2                                                      |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |       2     2        1                 3                    1  1     1   |     13  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                          1           1  2|      4  1.3|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |             3           2              3        3  2                 4   |      6  2.8|
      Pars Distalis, Angiectasis           |                                           3                              |      2  2.5|
      Pars Distalis, Cyst                  | 2                                                                        |      2  2.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                1                                                         |      1  1.0|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |    1  1        2     2  2        2  2  2  2                    3         |     14  1.8|
      Pars Distalis, Hemorrhage, Focal     |                            3                                2            |      6  2.8|
      Pars Distalis, Hyperplasia, Focal    |             2                             3                              |      5  2.4|
      Pars Nervosa, Hyperplasia, Atypical, |                                                                          |            |
           Focal                           |                                                                3         |      1  3.0|
      Rathke's Cleft, Cyst                 |                               3                                          |      2  2.5|
      Rathke's Cleft, Hemorrhage           |                         3                                                |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      C-Cell, Hyperplasia                  | 2  3  2  2  2        2  1  1  2  2  1  2  2  2  1  3  3  2  3  1  3  1  3|     45  2.1|
      Follicle, Mineralization, Focal      |             1           1  1  1     1  1     1  1  1  1  1     1         |     26  1.0|
      Follicular Cell, Hypertrophy         |                               1        1                                 |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                3                                                         |      2  3.0|
      Hyperplasia, Cystic, Focal           |                                           2                              |      1  2.0|
      Hyperplasia, Cystic                  |       2                                                           2      |      4  2.5|
      Inflammation, Chronic                |                                     1                       2            |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Cyst                                 |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Periovarian Tissue, Cyst             |                                                                          |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    2  1              2                          1        1              2|      7  1.4|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |    +                                                                     |   3        |
      Cyst                                 |    3                                                                     |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Myeloid Cell, Hyperplasia            |                                                                         3|      3  2.7|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hyperplasia                      |       3     3                                                            |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +  +  +  +  +  +  +  +  +     +  +     +     +        +  +  +|  34        |
      Mediastinal, Ectasia                 |                      3     3                       3                     |      4  3.0|
      Mediastinal, Hemorrhage              |                               3  3                 3                    3|      6  3.0|
      Mediastinal, Hyperplasia, Histiocytic|       3                    3                                      3      |      4  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                              2                           |      2  2.5|
      Mediastinal, Hyperplasia, Plasma Cell|       3                                                                  |      1  3.0|
      Pancreatic, Angiectasis              | 3                                                                        |      1  3.0|
      Pancreatic, Hemorrhage               | 2           4                                      3                     |      3  3.0|
      Pancreatic, Hyperplasia, Histiocytic | 2     3  2  3  2  2        3     1  2        2     2     2           2   |     22  2.2|
      Pancreatic, Pigmentation             | 3                    1  1                 2                       2      |      7  1.6|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M|   6        |
      Ectasia                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Histiocytic             |                            3     3                          3            |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                   3      |      1  3.0|
      Fibrosis, Focal                      |                                                                   3      |      1  3.0|
      Hematopoietic Cell Proliferation     | 2     3  2        4     2  2     3  2                 2                 3|     21  2.4|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |             4                                                  3         |      4  2.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Angiectasis                          |                                           2                              |      1  2.0|
      Cyst                                 |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |          4  3        2  4  3        2  2     2     4  2  2  3  4  4  3  4|     39  3.1|
      Ectasia                              |                                                                          |      1  2.0|
      Fibrosis                             |                   3                                                      |      1  3.0|
      Hyperplasia                          |       2        2                                2     2  2           2   |     11  2.2|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                    +|   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                                                       3  3        3  4   |      9  2.9|
      Hemorrhage, Focal                    |                   2                                                  2   |      4  2.3|
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |                                                       2                  |      1  2.0|
      Hyperplasia, Histiocytic             | 1                             1  2        1                              |      6  1.3|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                                     2                                   2|      3  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                1                                                         |      2  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cataract                             |                                                                3         |      3  2.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                3         |      2  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy, Diffuse                     |                                                                          |      1  4.0|
      Infarct                              |                3                                                         |      1  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                               3                       1                  |      2  2.0|
      Nephropathy                          |    1  1  1  1  2     1  1  1  4  2  1  1     1  1  1  2     1  1  1  1  1|     41  1.2|
      Pelvis, Inflammation, Chronic        |                                                                          |      1  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |    1        3                                      2                 2   |     12  2.0|
      Renal Tubule, Pigmentation           |                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|             
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                               2     2                                    |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X     X  X     X  X  X  X  X     X     X  X  X      |             
      Cholangiofibrosis                    |                         4                                                |             
      Clear Cell Focus                     |    X        X     X  X                 X  X     X           X     X      |             
      Congestion                           |                                                    3                     |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Eosinophilic Focus                   |                                     X                                    |             
      Hepatodiaphragmatic Nodule           |    2                    3        2                                2     3|             
      Hyperplasia, Focal, Histiocytic      |                1  2                 2  1     1     1           1         |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Polymorphonuclear                |    2                                                                     |             
      Infiltration Cellular, Mixed Cell    | 2     2  1     2  2  2     2  1        2  2  2  2     2     2  2  2  3   |             
      Mixed Cell Focus                     |                   X        X                          X                  |             
      Bile Duct, Hyperplasia               | 1     1           1     3        2  2  1     1  2  1  2  3  1  2  1      |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               | 2                 2           2                       2     1            |             
      Hepatocyte, Vacuolization Cytoplasmic|                3                                                         |             
      Hepatocyte, Periportal,              |                                                                          |             
          Centrilobular, Vacuolization     |                                                                          |             
          Cytoplasmic                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|             
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hepatocyte, Centrilobular, Necrosis  |                                                                      3   |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                         4        3                       4           3  3|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                   +     +  +  +  +                       +           +   |             
      Fat, Necrosis, Focal                 |                   2        3  3  3                                       |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +                                                               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                1        3  1     2        2                 1            |             
      Duct, Cyst, Focal                    |       1           1                                                      |             
      Duct, Cyst, Focal, Multiple          | 1              2     2                 1  3           1        1         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                3                                                         |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Perforation                          |                                                                      3   |             
      Epithelium, Hyperplasia              |                2                 3                                   3   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Malformation                         |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|             
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                               1  1                       1               |             
      Angiectasis                          |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fibrosis, Focal                      |    2                                                                     |             
      Vacuolization Cytoplasmic, Focal     | 1                                                           3            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                  1                                       |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                         2                                                |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                         3                                                |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              4                           |             
      Pars Distalis, Angiectasis           |                                                                         4|             
      Pars Distalis, Cyst                  |             3                                                            |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                   1           1                                          |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |          3  2           2     2  3                       1  3     2      |             
      Pars Distalis, Hemorrhage, Focal     |    3                                      3     3              3         |             
      Pars Distalis, Hyperplasia, Focal    |    3                       2              4                       2      |             
      Pars Distalis, Infiltration Cellular,|                                                                          |             
           Focal                           |                                                                          |             
      Rathke's Cleft, Hemorrhage           |                         2        3                                       |             
      Rathke's Cleft, Hyperplasia, Cystic  |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 3  2  2     2  2  3  2  1  3  3  3  3  2  3  3  3     3  2  2  3  3      |             
      Follicle, Mineralization, Focal      | 1  1  1     1  1  1  1  2  1  1  1  1  1  1  2  2     1  1  1  1  2      |             
      Follicular Cell, Hypertrophy         | 1  1  1                    1  1  1  2  2  1     1     1        1         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|             
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                          +               |             
      Mediastinum, Cyst                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                      2              3                       3        3   |             
      Hyperplasia, Cystic                  |                   3                       2                              |             
      Inflammation, Chronic                |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Interstitial Cell, Hyperplasia       |             3                                                            |             
      Periovarian Tissue, Cyst             |       4                                                                  |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |          +                       +                                       |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |       2     2                 1           1           2  2        1     2|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia                          |                                     2                                    |             
      Myeloid Cell, Hyperplasia            |                                                             2            |             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hyperplasia                      |                               3                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +     +  +     +  +  +  +     +  +     +     +  +  +  +           +  +|             
      Mediastinal, Angiectasis             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|             
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                     3                    3           3   |             
      Mediastinal, Hyperplasia, Histiocytic|                                                       3                  |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                 3                        |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |    3     2  3     3  3     2              2     2  3                     |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                      1   |             
      Pancreatic, Pigmentation             |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  +  M  M  M  +  +  M  M  M  M  +  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                2                                               1     4   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Pigmentation, Focal                  |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2                                         2                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 4  2  2     4  2     2  2  4  3     2  4     4  4     4        4  2      |             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          | 2              2                             3     2  3                  |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|             
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   | 2     2        3                    3              3  3                  |             
      Hemorrhage, Focal                    |                                  1                                      2|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3                                         3                     |             
      Hemorrhage, Focal                    |    3                                                                     |             
      Hyperplasia, Histiocytic             |          2                                                               |             
      Infiltration Cellular, Mixed Cell    |                                                                   2  2   |             
      Inflammation, Chronic, Focal         |       2                                                           2      |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    3                                                              2      |             
      Mediastinum, Edema                   |                                                                      3   |             
      Peribronchiolar, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|             
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Inflammation, Chronic, Focal         |                                                 1                        |             
      Metaplasia, Focal, Squamous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                        +                                 |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Cyst                                 |                                                                         2|             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Infarct                              |                                                          3               |             
      Nephropathy                          | 1  1  1  1  1  1  1  1     1  1  2  1  1  1     1  2  1  2     1  1      |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          | 2                          2                          2     2  2         |             
      Renal Tubule, Pigmentation           |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0|            |
                                           | 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      2  2.0|
      Basophilic Focus                     | X     X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X     X|     41     |
      Cholangiofibrosis                    |                                                                          |      1  4.0|
      Clear Cell Focus                     |          X  X     X  X        X        X  X        X           X         |     18     |
      Congestion                           | 2                                                                        |      2  2.5|
      Degeneration, Cystic, Focal          |                      2                                                   |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                               X                 3                 3      |      8  2.6|
      Hyperplasia, Focal, Histiocytic      |          1     2           1  1     2  3     2  3              1         |     16  1.6|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |       2  2  2  2  2  2  1  1  1  2  2  2  2  1  2  2           2        2|     35  1.9|
      Mixed Cell Focus                     | X                 X                                X              X      |      7     |
      Bile Duct, Hyperplasia               | 2     2     2  2  3  2  2  1  1  1  2  1  1  1        2     1  2  3  3   |     34  1.7|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                         2                                                |      1  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |             1        2     2     2  2                                    |     10  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0|            |
                                           | 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Vacuolization Cytoplasmic|                                              1                           |      2  2.0|
      Hepatocyte, Periportal,              |                                                                          |            |
          Centrilobular, Vacuolization     |                                                                          |            |
          Cytoplasmic                      |                                                                   2      |      1  2.0|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  3.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |    3                                                        3        4   |      8  3.4|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +  +        +     +           +                          +            |  13        |
      Fat, Necrosis, Focal                 |    3           2     3           3                          3            |      9  2.8|
      Fat, Necrosis                        |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |                   2                                1  1                  |      9  1.6|
      Duct, Cyst, Focal                    |                                                                   1     1|      4  1.0|
      Duct, Cyst, Focal, Multiple          |             1  2                                1  2                     |     11  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                         2                                                |      1  2.0|
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Perforation                          |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |    2                    2                                               3|      6  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |    1                                                                 2   |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                            +                 +                           |   2        |
      Malformation                         |                                              X                           |      1     |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0|            |
                                           | 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
           Chronic                         |                            3                 3                           |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mixed Cell    |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                1                                   1                     |      5  1.0|
      Angiectasis                          |       2                                                                  |      1  2.0|
      Cytoplasmic Alteration, Focal        |                      2                    2              2               |      3  2.0|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |          2  2        2        1  2                                       |      7  1.9|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                 3                        |      2  3.5|
      Pars Distalis, Angiectasis           |                                                          3               |      2  3.5|
      Pars Distalis, Cyst                  |                                                                          |      1  3.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      2  1.0|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                                           3                    2  3      |     11  2.4|
      Pars Distalis, Hemorrhage, Focal     |             2  3                 1     2  2        3                     |     10  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0|            |
                                           | 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |                   3                    2        3  3     3        3      |     10  2.8|
      Pars Distalis, Infiltration Cellular,|                                                                          |            |
           Focal                           |       2                                                                  |      1  2.0|
      Rathke's Cleft, Hemorrhage           |                                                                          |      2  2.5|
      Rathke's Cleft, Hyperplasia, Cystic  |                                        3                                 |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|  43        |
      Ultimobranchial Cyst                 |                                              1                           |      1  1.0|
      C-Cell, Hyperplasia                  | 3     3  3  3  2  1  3  3  2  2  3  3  2  2  3  3  3  2  3     2  2     2|     43  2.5|
      Follicle, Mineralization, Focal      | 3     1     1  1  1  1  1  1  2  1  1  2  1     3  1  1  1     2  1      |     40  1.3|
      Follicular Cell, Hypertrophy         | 2     1  1           2  1     1  2     1  1     2  1  1  1     1  1      |     27  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                               +              +              +            |   4        |
      Mediastinum, Cyst                    |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |    3                                                              3      |      6  2.8|
      Hyperplasia, Cystic                  |                                           2                              |      3  2.3|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                   3                                                      |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
      Periovarian Tissue, Cyst             |                                           3                              |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2  1        1                 3        3           2     2              3|     16  1.9|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0|            |
                                           | 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |       +                                                     +  +         |   3        |
      Cyst                                 |                                                                3         |      1  3.0|
      Inflammation, Suppurative            |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      3                                                   |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |                      4                 2                                 |      2  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                              3                           |      2  2.5|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hyperplasia                      |                                     3                                    |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +        +     +  +     +  +     +        +     +  +  +  +   |  30        |
      Mediastinal, Angiectasis             |                                              3                           |      1  3.0|
      Mediastinal, Ectasia                 |          3  3                                                            |      2  3.0|
      Mediastinal, Hemorrhage              |                            3        3                                    |      5  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                      3                                                   |      2  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                              3                           |      2  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Mixed Cell                      |                                        3                                 |      1  3.0|
      Mediastinal, Pigmentation            |                            3                                             |      1  3.0|
      Pancreatic, Hyperplasia, Histiocytic |       2              3        3              1        2              3   |     15  2.5|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  1.0|
      Pancreatic, Pigmentation             |                                              3                 1         |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   4        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal, Histiocytic      |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0|            |
                                           | 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hematopoietic Cell Proliferation     |       4  2           2              2                                   2|      8  2.4|
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |                               3                 4                        |      2  3.5|
      Pigmentation, Focal                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 4  3        2  4  3  4  2     4  4  3  3  3     2  2  3  2  2        3   |     34  3.0|
      Ectasia                              |       2                    4                                            2|      3  2.7|
      Fibrosis                             |             2                                                            |      1  2.0|
      Hyperplasia                          |    3     2  2                          3                 2               |     10  2.4|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                   3     3  4        3                                    |     10  2.9|
      Hemorrhage, Focal                    |                                                                      2   |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0|            |
                                           | 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      2  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |       2                    1                 2                          1|      5  1.6|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  2.0|
      Inflammation, Chronic, Focal         |          1  1                                                            |      4  1.5|
      Metaplasia, Focal, Osseous           |                   2                                                      |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                 1                        |      3  2.0|
      Mediastinum, Edema                   |                                                                          |      1  3.0|
      Peribronchiolar, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Cataract                             |                                                 3                        |      1  3.0|
      Retina, Degeneration                 |                                                 3                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |                                                 1                        |      1  1.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Metaplasia, Focal, Squamous          |                                                    3                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0|            |
                                           | 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  47        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Nephropathy                          | 1        1  1  1  1  1  1  1     1  1  1  1        1  1        1  1     1|     37  1.1|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |       3           3        2        2        2  2                        |     11  2.2|
      Renal Tubule, Pigmentation           |       1                    2                 2                           |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  I  +  +  A  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Cyst                     |                                                    1                     |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X  X  X  X  X  X  X  X        X     X  X  X  X  X  X  X  X  X  X|             
      Cholangiofibrosis                    |    4                                                                     |             
      Clear Cell Focus                     |                   X     X     X                    X        X  X        X|             
      Congestion                           |                                                                          |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Eosinophilic Focus                   |                                                          X               |             
      Fibrosis, Focal                      |                                                                          |             
      Hepatodiaphragmatic Nodule           |       3              2                                                   |             
      Hyperplasia, Focal, Histiocytic      | 2  3        2  2              1                       2        1  3  2  1|             
      Hyperplasia, Focal, Regenerative     |    4                                                                     |             
      Hyperplasia, Regenerative            |                                                                          |             
      Infiltration Cellular, Mixed Cell    | 2        2  2  1  2  2  2  2  2        2  2     2  2  2     2  2  2  2  2|             
      Mixed Cell Focus                     |                               X                 X        X               |             
      Bile Duct, Hyperplasia               |    3  2           2     2  2     3  3        3     2     3  2           2|             
      Hepatocyte, Necrosis, Focal          |                                                                          |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                     3                                    |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |       2  1              1  1                                1            |             
      Hepatocyte, Centrilobular, Necrosis  |                                           2                              |             
      Hepatocyte, Centrilobular,           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
          Vacuolization Cytoplasmic        |                                  3        2                              |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +           +     +        +  +     +        +  +              +   |             
      Fat, Necrosis, Focal                 |       3           3     2           3              2  2              3   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lipomatosis                          |                                                 1                        |             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               |       1  1  2  1        2              2  2  1  1  1  2                  |             
      Duct, Cyst, Focal                    |          2                                                               |             
      Duct, Cyst, Focal, Multiple          |             1              2  1  2           2     1  2           1     2|             
      Duct, Hyperplasia, Focal             |                                                             1            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  2                                       |             
      Ulcer                                |                                           2                              |             
      Epithelium, Hyperplasia              |                                           2                              |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                          1               |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic, Focal                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                            2                                             |             
      Infiltration Cellular, Mixed Cell    |                                                 1  1        2  2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         1                                                |             
      Angiectasis                          |                                        3                          3      |             
      Cytoplasmic Alteration, Focal        |                                  2                                       |             
      Degeneration, Cystic, Focal          |                                  2                                       |             
      Hemorrhage                           |                                  2                                       |             
      Vacuolization Cytoplasmic, Focal     |                         2           2        1  1                        |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   3      |             
      Hyperplasia, Focal                   |          1                                                               |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                   3  2  3  3         |             
      Pars Distalis, Cyst                  |                                              2                           |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                           1                    3         |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                  2                                       |             
      Pars Distalis, Hemorrhage, Focal     |    3                                                                     |             
      Pars Distalis, Hyperplasia, Focal    |                   2                                                  2   |             
      Rathke's Cleft, Hemorrhage           |          3                             3                 2               |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|             
      Congestion                           |    1                                                                     |             
      C-Cell, Hyperplasia                  | 1  2  1  2  2  3  3  2  3  2  3  3  2  2     2  3  2        2  3  3  2  3|             
      Follicle, Mineralization, Focal      |    3  2  2  3  3  2  3  2  3  3  1  1  3     3  3  2  3     2  2  2  2  1|             
      Follicular Cell, Hypertrophy         |    2  2  3  2  2  1  2  1  2  2     2  2     2  1  1  2     2  1  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
   Tissue NOS                              |                                  +  +     +              +               |             
      Mediastinum, Thrombosis              |                                     3                                    |             
      Oral, Foreign Body, Focal            |                                                                          |             
      Oral, Necrosis, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                 3                        |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                      1  3                                                |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        2                          2      |             
      Corpus Luteum, Hyperplasia           |       3                                                                  |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer, Chronic Active                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    2     2                                         1  2           2  1   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
      Hyperplasia, Focal, Histiocytic      |                               4        4                                 |             
      Myeloid Cell, Hyperplasia            |                                           3                              |             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +           +  +  +  +     +  +  +  +  +  +  +  +  +  +     +      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pigmentation                         |                                                                          |             
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |             
          Cell                             |                                                                          |             
      Mediastinal, Ectasia                 |                                                    3                     |             
      Mediastinal, Hemorrhage              |                         3                                                |             
      Mediastinal, Hyperplasia, Histiocytic|                                                    3                     |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                             3            |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               | 2                                      3              2                  |             
      Pancreatic, Hyperplasia, Histiocytic | 1  3  3           3                    3  2  3  3     2     2     3      |             
      Pancreatic, Pigmentation             | 2                    1     1                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                        3           3                     |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |          2     2              3        3  3                    2        1|             
      Hemorrhage                           |                      2                                                   |             
      Hyperplasia, Focal, Histiocytic      |    3                                                  4                  |             
      Infarct                              |                                                                          |             
      Red Pulp, Fibrosis, Diffuse          |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     3                                    |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    4  3  4  4  4     3     3  4  3  2     2     4  3  4  3  3  3  2  2  2|             
      Ectasia                              | 3                                                                        |             
      Fibrosis                             |             3  3                                                         |             
      Hyperplasia, Focal                   | 4                                                                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Hyperplasia                          |                3                                                     2   |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   | 4                    3                          3                        |             
      Hemorrhage, Focal                    |                                  1                       2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          3               |             
      Hemorrhage, Focal                    |                                           3              3               |             
      Hyperplasia, Focal, Histiocytic      |                                  3                                       |             
      Hyperplasia, Histiocytic             | 1                                                                        |             
      Infiltration Cellular, Mixed Cell    |                                           3                              |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                      1                                                   |             
      Interstitium, Edema                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Focal, Squamous                 |                                                             2            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |    3                                                                     |             
      Bilateral, Atrophy                   |                                                                          |             
      Retina, Degeneration                 |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic, Focal         |                   1                                                      |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                +                                                         |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic, Focal,        |                                                                          |             
          Granulomatous                    |                                                                          |             
      Nephropathy                          |    2  1  1  2  1  1  1  1  1  1  3     1  1  1  1  1  1           1     2|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                               2                                2         |             
      Renal Tubule, Pigmentation           | 1                                3                                       |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Cyst                     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X  X  X  X     X  X  X  X  X  X  X  X     X  X  X  X  X     X  X  X|     42     |
      Cholangiofibrosis                    |                   4                                            4         |      3  4.0|
      Clear Cell Focus                     |                         X                                   X     X      |     10     |
      Congestion                           |                      2                                                   |      1  2.0|
      Degeneration, Cystic, Focal          |    2  2                                               2                  |      3  2.0|
      Eosinophilic Focus                   |                                                                X         |      2     |
      Fibrosis, Focal                      |                                        1                                 |      1  1.0|
      Hepatodiaphragmatic Nodule           |          X                                                               |      3  2.5|
      Hyperplasia, Focal, Histiocytic      | 1  3  1     3     3  2  1  1     2     1  1        2                    2|     23  1.8|
      Hyperplasia, Focal, Regenerative     |                                                                          |      1  4.0|
      Hyperplasia, Regenerative            |                4  4                                                      |      2  4.0|
      Infiltration Cellular, Mixed Cell    | 2  3  2  2  2  2  3  1  2  2  2  2     2  2  2  2  2        2  2  2  1  2|     41  2.0|
      Mixed Cell Focus                     | X  X     X              X                 X                              |      8     |
      Bile Duct, Hyperplasia               |    3  2     1  3           2     1  3     1     1  1        1  3  1     1|     26  2.0|
      Hepatocyte, Necrosis, Focal          |                2                                                         |      1  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                              3                           |      2  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |       2        2                                2        1  1            |     10  1.4|
      Hepatocyte, Centrilobular, Necrosis  |                                              3                           |      2  2.5|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                2         |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +                 +           +        +           +  +  +            |  16        |
      Fat, Necrosis, Focal                 |    2                 3           2                    3  3  3            |     13  2.6|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                              +                           |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Lipomatosis                          |                                                                          |      1  1.0|
      Acinus, Atrophy, Diffuse             |                                                          4               |      1  4.0|
      Acinus, Atrophy, Focal               |                            1        2                 1              2  1|     16  1.4|
      Duct, Cyst, Focal                    |                                                                          |      1  2.0|
      Duct, Cyst, Focal, Multiple          |          2     2        1        1        2        2  1  2              1|     18  1.6|
      Duct, Hyperplasia, Focal             |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                          2               |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                              +                           |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic, Focal                  |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                2         |      2  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                      1   |      2  1.0|
      Angiectasis                          |                                                                          |      2  3.0|
      Cytoplasmic Alteration, Focal        |                                  1                                       |      2  1.5|
      Degeneration, Cystic, Focal          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                         3|      2  2.5|
      Vacuolization Cytoplasmic, Focal     | 2              2        2                          2                     |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphoid                         |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2        3        2                    3        2  3     3     3      |     13  2.6|
      Pars Distalis, Cyst                  |                               1                                          |      2  1.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                    1                     |      3  1.7|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |             2           2                                                |      3  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Pars Distalis, Hemorrhage, Focal     |          3                                                               |      2  3.0|
      Pars Distalis, Hyperplasia, Focal    |                      2                                      1            |      4  1.8|
      Rathke's Cleft, Hemorrhage           |       3           3                 3                                    |      6  2.8|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +|  46        |
      Congestion                           |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  | 3  3  2  2  3  1  2  3  2  3  2  3  2  3  1     1  2  2     3  2  2  3   |     44  2.3|
      Follicle, Mineralization, Focal      | 1  3  3  3  1  1  1  1  1  1     1  1  2  3     1  2  2     2  2  3  3  3|     44  2.1|
      Follicular Cell, Hypertrophy         | 2  2  2  1  1  3  1  2     2     1  2  2  1     2  1  2     2  2  2  3  3|     42  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                     +                    +               |   6        |
      Mediastinum, Thrombosis              |                                                                          |      1  3.0|
      Oral, Foreign Body, Focal            |                                     3                                    |      1  3.0|
      Oral, Necrosis, Focal                |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Hyperplasia, Cystic                  |                                        3                                 |      1  3.0|
      Hyperplasia                          |                                                          3               |      1  3.0|
      Inflammation, Chronic                |                                        3                                 |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       2                          1                                       |      4  1.8|
      Corpus Luteum, Hyperplasia           |                                                                          |      1  3.0|
      Periovarian Tissue, Cyst             |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |             3                                                            |      1  3.0|
      Inflammation, Focal, Suppurative     |                   3                                                      |      1  3.0|
      Inflammation, Suppurative            |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Ulcer, Chronic Active                |             4                                                            |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |             3     3     1                          1                 2   |     11  1.8|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                             +            |   1        |
      Cyst                                 |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      2  4.0|
      Myeloid Cell, Hyperplasia            |                3  3              2                    2           3      |      6  2.7|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hyperplasia                      | 3                                            3           3               |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +  +     +  +  +  +  +  +  +  +     +     +  +  +  +  +  +|  39        |
      Pigmentation                         |             3                                                            |      1  3.0|
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |            |
          Cell                             |                                              3                           |      1  3.0|
      Mediastinal, Ectasia                 |                         3                                      3  3      |      4  3.0|
      Mediastinal, Hemorrhage              |                                           3                       2      |      3  2.7|
      Mediastinal, Hyperplasia, Histiocytic|                                  3                                      3|      3  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                   3                                                  3   |      3  3.0|
      Pancreatic, Ectasia                  | 3                                                                        |      1  3.0|
      Pancreatic, Hemorrhage               | 3                 3                                                      |      5  2.6|
      Pancreatic, Hyperplasia, Histiocytic | 3  1     3  3  3  1     3  2     3        2        2        2  2     3   |     25  2.4|
      Pancreatic, Pigmentation             |                               2     2  2                                 |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M|   5        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                   3                                                      |      1  3.0|
      Hyperplasia, Histiocytic             | 4              3                                                         |      4  3.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                     3                                    |      1  3.0|
      Fibrosis, Focal                      |                                     3                                    |      1  3.0|
      Hematopoietic Cell Proliferation     |             3  2  3           2           2  3  2     2           3     3|     17  2.4|
      Hemorrhage                           |                                                          3               |      2  2.5|
      Hyperplasia, Focal, Histiocytic      | 4                 3                                               4      |      5  3.6|
      Infarct                              |                                                          3               |      1  3.0|
      Red Pulp, Fibrosis, Diffuse          |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 3  2  4  2           4     4        3  4  3  3     2  4  2  3  3  3  2  4|     38  3.1|
      Ectasia                              |             2                                                            |      2  2.5|
      Fibrosis                             |                                                       3              2   |      4  2.8|
      Hyperplasia, Focal                   |                                                                          |      1  4.0|
      Hyperplasia                          |          2           2     3                    2     3           2  2   |      9  2.3|
      Inflammation, Chronic                |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   | 3        3     3                                      3  2     3         |      9  3.0|
      Hemorrhage, Focal                    |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |                                                                          |      2  3.0|
      Hyperplasia, Focal, Histiocytic      |                                                          3               |      2  3.0|
      Hyperplasia, Histiocytic             |             1                                                            |      2  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                      1                    1                              |      2  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                   2      |      2  1.5|
      Interstitium, Edema                  |                                                          3               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation      |                                              3                           |      1  3.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Focal, Squamous                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |                      3                                                   |      2  3.0|
      Bilateral, Atrophy                   |                                              4                           |      1  4.0|
      Retina, Degeneration                 |                      2                                                   |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |             1                                                            |      1  1.0|
      Inflammation, Chronic, Focal         |                   1                                                      |      2  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                       +                  |   2        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +|  47        |
      Atrophy, Focal                       |             3                                         3                  |      2  3.0|
      Cyst                                 |                                                                      2   |      1  2.0|
      Inflammation, Chronic, Focal,        |                                                                          |            |
          Granulomatous                    |                      3                                                   |      1  3.0|
      Nephropathy                          | 2  1  1  1  2  1  2     1  1  1  1  1  1  1     1     3        1     1  1|     38  1.3|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          | 2  2                                2                                    |      5  2.0|
      Renal Tubule, Pigmentation           |             2                       3                                    |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|             
                                           | 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                              2                           |             
      Basophilic Focus                     | X     X     X  X     X     X  X     X  X        X  X  X     X  X  X     X|             
      Cholangiofibrosis                    |                4        2                                                |             
      Clear Cell Focus                     |       X     X        X  X  X  X           X     X  X  X     X  X  X     X|             
      Degeneration, Cystic, Focal          |    2  2                 1  2              1  1                 1        1|             
      Eosinophilic Focus                   |    X                                                                     |             
      Hemorrhage, Focal                    |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      2  3  3                                             |             
      Hyperplasia, Focal, Histiocytic      |                2                                                     1  1|             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    | 2     2     2  2     2  2  2  2  2  2  2  2     2  2  2     2     2  1  2|             
      Mixed Cell Focus                     |                            X  X     X  X  X        X  X     X        X   |             
      Bile Duct, Hyperplasia               | 3  3  3  3  3  3  2  3  3  3  2     3  3  3  3  3  3  3     3  3  3  3  3|             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |          2                       2                                       |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               | 2     2              2  2  1  2        1  2     2  2  1     1     1     2|             
      Hepatocyte, Centrilobular, Necrosis  |                                                          4               |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                   3                                                      |             
      Hepatocyte, Midzonal, Necrosis       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|             
                                           | 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |                                     2                                2   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +  +        +  +     +        +  +              +  +  +            |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis, Focal                 |       3  2           3     3        3  2              3     3            |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy, Focal               | 1        1        3           2     3     1        2  1        2  1  1   |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Duct, Cyst, Focal, Multiple          |    2     1              1           2     2  2        1     1        2   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Cyst                     |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1                 1                                2      |             
      Infiltration Cellular, Mixed Cell    |       2                                                                  |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation, Chronic, Focal |                                                                         2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|             
                                           | 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Endocardium, Valve, Inflammation,    |                                                                          |             
           Chronic, Focal                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                  1                 2                     |             
      Vacuolization Cytoplasmic, Focal     |          2     1     1              2           2     1                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hyperplasia, Focal                   |                   1        2                                             |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                        1  1                 2            |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                                                         1|             
      Pars Distalis, Hemorrhage, Focal     |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                         2|             
      Rathke's Cleft, Hemorrhage           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  3  1  2     3  1  2  3  2  2  2     2  2  1  2  1  2     1  2  2  2  3|             
      Follicle, Cyst                       |                                              2                           |             
      Follicle, Degeneration, Cystic, Focal|                                                                          |             
      Follicle, Mineralization, Focal      | 1  2  1  1  1  1  1  1  1  2  1     1  1  1  1  1  1  1     1  1  1  1  1|             
      Follicular Cell, Hypertrophy, Focal  |                                                                          |             
      Follicular Cell, Hypertrophy         |                               2     1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|             
                                           | 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                         +                          +           +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +|             
      Inflammation, Chronic                |    2              1     2        1     2           1  2        2     3   |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                3  2  1     1        2  1     1                       3  2|             
      Mineralization, Focal                |       2                                                                  |             
      Epithelium, Hyperplasia, Focal       |    1        1        1                          1                 1      |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Germinal Epithelium, Degeneration    |                                  2                                       |             
      Interstitial Cell, Hyperplasia, Focal|                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          | 3  3     1  2              1           2  1  3     1  1     3  4  2     1|             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hyperplasia                      |       3                    2                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +     +  +     +     +  +        +     +  +  +     +  +     +  +  +   |             
      Ectasia                              |             4                                                            |             
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |             
          Cell                             |                                           3                              |             
      Mediastinal, Ectasia                 |                                                                   3      |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                   3      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|             
                                           | 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Ectasia                  |                         3           2                                    |             
      Pancreatic, Hemorrhage               |             3                                                            |             
      Pancreatic, Hyperplasia, Histiocytic |                            3                          3              3   |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                 3                        |             
      Pancreatic, Pigmentation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia, Histiocytic             |                                        3                                3|             
      Hyperplasia, Lymphoid                |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           3                              |             
      Hematopoietic Cell Proliferation     | 2                                                                        |             
      Hemorrhage                           |                   3                                                      |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Necrosis                             |                                                                          |             
      Capsule, Accessory Spleen, Focal     |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Dilatation                           |                3                                                     3   |             
      Inflammation, Chronic, Focal         |                                                                         2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis, Focal                |                                        3                                 |             
      Epidermis, Hyperplasia, Focal        |                                        3                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|             
                                           | 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                4                                                     3   |             
      Hemorrhage, Focal                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                      +   |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body, Focal                  |                                                                          |             
      Hemorrhage, Focal                    |                      1                       2                          1|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                      2        2     2        3                          1|             
      Alveolus, Hyperplasia, Focal,        |                                                                          |             
          Histiocytic                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Chronic                |                                           2                              |             
      Inflammation, Suppurative            |                                                                         2|             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|             
                                           | 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Infarct, Multiple                    |                                                                          |             
      Nephropathy                          | 1  1  1  1  2  1     2  2  2  2  1  1  1  2  1  2  2  2     1  1  1  2  2|             
      Renal Tubule, Pigmentation           |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9|            |
                                           | 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Ulcer                                |                                                                      4   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                       1                  |      2  1.5|
      Basophilic Focus                     |    X  X  X  X        X     X     X              X     X           X  X   |     27     |
      Cholangiofibrosis                    |                                                                          |      2  3.0|
      Clear Cell Focus                     |    X     X  X           X                       X     X           X      |     21     |
      Degeneration, Cystic, Focal          |                         1  1     2        2                 1            |     13  1.4|
      Eosinophilic Focus                   |          X                                                               |      2     |
      Hemorrhage, Focal                    |                                        3                                 |      1  3.0|
      Hepatodiaphragmatic Nodule           |       3                 2                             3                  |      6  2.7|
      Hyperplasia, Focal, Histiocytic      |                2           3     2                                       |      6  1.8|
      Infarct                              |                3                                                         |      1  3.0|
      Infiltration Cellular, Mixed Cell    |    2  2     2  2     2  2  2     2  2        2  2     2  2  2  2  2  2   |     36  2.0|
      Mixed Cell Focus                     |                      X     X     X                    X                  |     13     |
      Bile Duct, Hyperplasia               | 3  3  3  3  3  3  2  3  3  3  3  3  2  2  3  1  3  3  2  3  3  3  3  3  3|     48  2.8|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                             3            |      3  2.3|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |    2  3  2  2        2  1  2     1           2        2  2        3      |     26  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9|            |
                                           | 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  4.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        | 3              2  3                                                      |      4  2.8|
      Hepatocyte, Midzonal, Necrosis       |                                                    3                     |      1  3.0|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |                                        2  3                    3        3|      6  2.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                +  +        +     +  +  +           +  +        +         |  19        |
      Hemorrhage                           |                                        4                                 |      1  4.0|
      Fat, Necrosis, Focal                 |                            3     3                    3        2         |     12  2.8|
      Fat, Necrosis                        |                3                    3                                    |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                3                                                         |      1  3.0|
      Acinus, Atrophy, Focal               | 2  1  1        2  2     1     3           2  3        3        3     1   |     23  1.8|
      Acinus, Hyperplasia, Focal           |                      3                                                   |      1  3.0|
      Duct, Cyst, Focal, Multiple          |    1                    1        2           2        2        4         |     15  1.7|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                    3                     |      1  3.0|
      Ulcer                                |                                                             2            |      1  2.0|
      Epithelium, Cyst                     |                                                 2                        |      1  2.0|
      Epithelium, Hyperplasia              |                   2                                         2            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                   1                       1                 2            |      3  1.3|
      Ulcer                                |                                                    3                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |       +                                                                  |   1        |
      Epithelium, Hyperplasia              |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9|            |
                                           | 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                              +                           |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2        1                                            2               |      6  1.5|
      Infiltration Cellular, Mixed Cell    |                                        1                                 |      2  1.5|
      Thrombosis                           |                                           3                              |      1  3.0|
      Artery, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
      Endocardium, Valve, Inflammation,    |                                                                          |            |
           Chronic, Focal                  |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |          1                                                               |      1  1.0|
      Cytoplasmic Alteration, Focal        |          1                                                               |      3  1.3|
      Vacuolization Cytoplasmic, Focal     |       2              1     1                             2     2        1|     12  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                            2                             1              2|      5  1.6|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                            3                    1                        |      2  2.0|
      Pars Distalis, Cyst                  |                               1                    2                     |      2  1.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      3  1.3|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                                           1                              |      2  1.0|
      Pars Distalis, Hemorrhage, Focal     |                   3  3                                                   |      2  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9|            |
                                           | 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |                   1                             3                       3|      4  2.3|
      Rathke's Cleft, Hemorrhage           |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +|  47        |
      C-Cell, Hyperplasia                  | 2  1  1  1  1  2  1  2  2  1  2  2  1     1  2  3  2  2  2     3  2  3  2|     45  1.8|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicle, Degeneration, Cystic, Focal|                            1                    2                        |      2  1.5|
      Follicle, Mineralization, Focal      | 1  1  1  1  1  1  1  1  1  1  1  1  1        1  1  1  1  3     1  1  1  1|     45  1.1|
      Follicular Cell, Hypertrophy, Focal  |                                                          1               |      1  1.0|
      Follicular Cell, Hypertrophy         |                                  1                                1      |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                           +        +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |    2  1     1  2  2           2  1           2     1     2  3        1  2|     22  1.7|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    3        1  1     3     2                    2  1  2  2     3  3  1   |     21  1.9|
      Mineralization, Focal                |                                              2                          2|      3  2.0|
      Epithelium, Hyperplasia, Focal       |    2                    1        2              2     1  1               |     11  1.3|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                  3                 3        3     3      |      4  3.0|
      Germinal Epithelium, Degeneration    |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia, Focal|                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9|            |
                                           | 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis                             |                               2                    4                     |      2  3.0|
      Hyperplasia                          |          1     3     2  1  1     2  3     3  1  1     1        2  2  3   |     28  1.9|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hyperplasia                      |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +   |  34        |
      Ectasia                              |                                                                          |      1  4.0|
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
      Mediastinal, Ectasia                 |       2                                         2           3        3   |      5  2.6|
      Mediastinal, Hemorrhage              |                         3                             3     3            |      3  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                      3                                                   |      1  3.0|
      Pancreatic, Angiectasis              |                3                    3                                    |      2  3.0|
      Pancreatic, Ectasia                  |                                                                      3   |      3  2.7|
      Pancreatic, Hemorrhage               |                2        3                    3           3               |      5  2.8|
      Pancreatic, Hyperplasia, Histiocytic |    3                       3                    3              3  3      |      8  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Pancreatic, Pigmentation             |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  +  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M|   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                                                      3   |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |                                                 2                        |      1  2.0|
      Hyperplasia, Histiocytic             |                3                                                         |      3  3.0|
      Hyperplasia, Lymphoid                |                3                                                         |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                     3                                    |      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9|            |
                                           | 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Focal, Histiocytic      |                            3                                             |      1  3.0|
      Necrosis                             |                                           4                              |      1  4.0|
      Capsule, Accessory Spleen, Focal     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Dilatation                           |    2                                                  1  3     4  3      |      7  2.7|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |    4                                               3              3      |      3  3.3|
      Hyperkeratosis, Focal                |                                                                          |      1  3.0|
      Epidermis, Hyperplasia, Focal        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |    2                                                     4     3  3      |      6  3.2|
      Hemorrhage, Focal                    |                   3                                                     2|      2  2.5|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                          +               |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                          +               |   2        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9|            |
                                           | 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                     2  2                                 |      2  2.0|
      Foreign Body, Focal                  |                         2                                                |      1  2.0|
      Hemorrhage, Focal                    |                                                                          |      3  1.3|
      Hyperplasia, Histiocytic             |                1                    1                                    |      2  1.0|
      Infiltration Cellular, Mixed Cell    |                                        2                                 |      1  2.0|
      Inflammation, Chronic, Focal         |    3                    2     2                                1        3|      5  2.2|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    3                 1                                   1               |      8  1.9|
      Alveolus, Hyperplasia, Focal,        |                                                                          |            |
          Histiocytic                      |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |             1                                                            |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Hyperplasia, Focal       |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Infarct, Multiple                    |                                                    4                     |      1  4.0|
      Nephropathy                          | 2  2  1  1  1  3  2  1  1  1  2  1  2           1  1  2  3  1  3  3  1  2|     45  1.6|
      Renal Tubule, Pigmentation           | 3              2                    2                                    |      4  2.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9|            |
                                           | 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|             
                                           | 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
      Edema                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |             2                                                            |             
      Basophilic Focus                     |    X  X     X  X        X  X  X     X  X        X  X  X  X     X     X   |             
      Cholangiofibrosis                    |                         1                                                |             
      Clear Cell Focus                     |       X                       X                 X  X     X     X        X|             
      Congestion                           | 3                                                                        |             
      Degeneration, Cystic, Focal          |       1     2     2                                                      |             
      Eosinophilic Focus                   | X                                                                 X      |             
      Fibrosis, Focal                      |                         3                                                |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                                2         |             
      Infiltration Cellular, Mixed Cell    |    2  2     2  2        2     2        2        2  2  2  2  2  2     2   |             
      Mixed Cell Focus                     |       X     X  X              X                                X         |             
      Bile Duct, Hyperplasia               | 3  3  3  3  2  3  3  3  3  3  3  3  4  3  3  3  3  3  3  3  3  3  3  3  3|             
      Centrilobular, Congestion            |                                                                          |             
      Hepatocyte, Necrosis, Focal          |                                           2                              |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                           2                              |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |       2                 1  2                    2  1  2        2     2   |             
      Hepatocyte, Periportal, Necrosis     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|             
                                           | 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hepatocyte, Periportal,              |                                                                          |             
          Vacuolization Cytoplasmic        | 2                                                                        |             
      Hepatocyte, Centrilobular, Necrosis  |                                                             2            |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |                      4           4  3        3              2            |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic, Focal               |                               3                                          |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Portal, Fibrosis                     |                                                                          |             
      Portal, Hemorrhage                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +  +  +           +  +  +     +           +        +  +      |             
      Angiectasis                          |                                                                          |             
      Fat, Necrosis, Focal                 |                3              3           3           3        2         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 4     3  3        2        1  3     3     3        3           1     1   |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Duct, Cyst, Focal, Multiple          | 2                             2     2           2                        |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                      2                                                   |             
      Inflammation, Focal                  |                                                                          |             
      Ulcer                                |                                  2                                       |             
      Epithelium, Hyperplasia              |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
      Erosion                              |                                                                          |             
      Pigmentation, Focal                  |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|             
                                           | 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Peridontal Tissue, Hyperplasia,      |                                                                          |             
          Squamous                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                              2  2                        |             
      Infiltration Cellular, Mixed Cell    |                                                             2            |             
      Thrombosis                           |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          1  1                                                     1  1   |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                       1              2   |             
      Capsule, Fibrosis, Focal             |                                                          2               |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    1        2                 2     1                                    |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                   2                                                      |             
      Hyperplasia                          | 2                                   2                                    |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                          2                       2                     |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |    2              1                                                      |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                                          3           3   |             
      Pars Distalis, Hemorrhage, Focal     |                                                                   3      |             
      Pars Distalis, Hyperplasia, Focal    | 4                                                                    3   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|             
                                           | 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Rathke's Cleft, Hyperplasia, Cystic  |                                                                         2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  A  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  1  2     3  2  3  3  2  3  2  2  1  2        2  2     2     3  1     1|             
      Follicle, Mineralization, Focal      | 1  1  1     1     1  1  1  1  1  2  1  1        1  2     2     2  1  1  1|             
      Follicular Cell, Hypertrophy         |       1     1        1           2                 1           1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |             +                                                            |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |          +                       +  +     +                 +            |             
      Mediastinum, Hemorrhage              |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Penis                                   |                                     +           +                        |             
      Thrombosis                           |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic                |       2                    1        1                 2                 3|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2     1           1  1  2     2     3                 2  2  2           3|             
      Mineralization, Focal                |          3                                                     2         |             
      Epithelium, Hyperplasia, Focal       |                                                 1              1     1   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3     3                    3                    3                  |             
      Bilateral, Atrophy                   |                                     3                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|             
                                           | 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |    3  1     2  1  4        3  2        2     2  1  2     2  3  1  1  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +     +     +  +  +     +                       +  +  +|             
      Mediastinal, Ectasia                 | 3     3                                   3                              |             
      Mediastinal, Hemorrhage              | 3                                                                    2   |             
      Mediastinal, Hyperplasia, Histiocytic| 3              3        3                                                |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Polymorphonuclear               | 3                                                                        |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Pancreatic, Ectasia                  |                               3                                          |             
      Pancreatic, Hemorrhage               | 3                                                                        |             
      Pancreatic, Hyperplasia, Histiocytic |    3           3                                                         |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Pigmentation             |    2                                                                     |             
      Renal, Hyperplasia, Focal,           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  +  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             3                                                            |             
      Hemorrhage                           |             2                                                            |             
      Hyperplasia, Histiocytic             |    3                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3                                                                        |             
      Angiectasis, Focal                   |                   3                 3                                    |             
      Fibrosis, Focal                      |                   3                 3                                    |             
      Hematopoietic Cell Proliferation     |    3                                                  2     3            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|             
                                           | 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hemorrhage                           |                                           2                              |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Lymphoid Follicle, Atrophy           | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      3                             3  3                  |             
      Hyperplasia                          |                                                                2         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                   3                                                      |             
      Fibrosis, Focal                      |                               3                                          |             
      Inflammation, Chronic, Focal         |                   3           3                                          |             
      Ulcer                                |                                              3                           |             
      Artery, Subcutaneous Tissue,         |                                                                          |             
          Thrombosis                       |                                                                          |             
      Lip, Inflammation, Chronic, Focal    |                                                       3                  |             
      Subcutaneous Tissue, Cyst            |                4                                                         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic, Focal                  |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                      3        3                       2           3      |             
      Hemorrhage, Focal                    |                                              4                           |             
      Cerebrum, Ventricle, Hydrocephalus   |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|             
                                           | 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        3                                 |             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia, Histiocytic             |    1                                                                     |             
      Infiltration Cellular, Mixed Cell    |                                                                      2   |             
      Inflammation, Chronic, Focal         |                                                 1     1                  |             
      Inflammation, Focal, Suppurative     | 3                                                                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |          1        2                                                      |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Squamous                        |                                     3                                    |             
      Interstitium, Edema                  |             3                                                            |             
      Mediastinum, Edema                   |             3                                                            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          2                                                               |             
      Inflammation, Suppurative            |          3                                                               |             
      Nasolacrimal Duct, Inflammation      |                   3              2                                   1   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Edema           |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                               3                                         2|             
      Exudate                              |                                                                         3|             
      Retina, Degeneration                 |                               4                                         3|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                       2                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|             
                                           | 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    125 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          | +                                                                        |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                         2|             
      Hydronephrosis                       |                         4                                                |             
      Infarct, Multiple                    |                                                                          |             
      Metaplasia, Focal, Lipocyte          |                                                                         3|             
      Nephropathy                          | 2  1  2     1  1  1  2  2  1  2     1  1        2  2     2  1  1  1     2|             
      Cortex, Medulla, Atrophy             |                         4                                                |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                         2                                                |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
      Renal Tubule, Pigmentation           |    1                                                        2            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                         3                                                |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Diffuse                         |                         2                                                |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3|            |
                                           | 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
      Edema                                |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
      Ulcer                                |                                                                      3   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Basophilic Focus                     | X  X     X     X  X  X        X  X        X        X     X  X  X  X     X|     30     |
      Cholangiofibrosis                    |                                                                          |      1  1.0|
      Clear Cell Focus                     | X        X     X              X                    X  X  X  X  X  X     X|     18     |
      Congestion                           |                            3                                             |      2  3.0|
      Degeneration, Cystic, Focal          |          1     1                    2              2  2     2            |      9  1.7|
      Eosinophilic Focus                   |                                     X                                    |      3     |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           | 3                                                  3                     |      2  3.0|
      Hyperplasia, Focal, Histiocytic      |                                                    1                     |      2  1.5|
      Infiltration Cellular, Mixed Cell    | 2  2        2  2  2  2        2  2                 2  2  2  2  2  1     1|     29  1.9|
      Mixed Cell Focus                     |    X                 X        X           X                       X     X|     11     |
      Bile Duct, Hyperplasia               | 3  3  3  3  3  2  3  1     3  3  2  3  3  3  2  3  3  3  3  3  3  3  3  3|     49  2.9|
      Centrilobular, Congestion            |       3                                                                  |      1  3.0|
      Hepatocyte, Necrosis, Focal          |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3|            |
                                           | 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Cytoplasmic, Diffuse             |                                              4        2                  |      3  2.7|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |    1           2  2              1                          2  2        1|     15  1.7|
      Hepatocyte, Periportal, Necrosis     |                         3                                                |      1  3.0|
      Hepatocyte, Periportal,              |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                          |      1  2.0|
      Hepatocyte, Centrilobular, Necrosis  |       2                                2                                 |      3  2.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |       3                                3        2                    3   |      9  3.0|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic, Focal               |                                                                          |      1  3.0|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |                         3                                                |      1  3.0|
      Portal, Fibrosis                     |                         3                                                |      1  3.0|
      Portal, Hemorrhage                   |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +           +  +     +           +     +  +  +                 +  +   |  20        |
      Angiectasis                          |                                                                      3   |      1  3.0|
      Fat, Necrosis, Focal                 |                   3     3           2     3  2                           |     10  2.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               | 1  1  3                 1     3     2     1     2  1  2     1           3|     23  2.1|
      Acinus, Hyperplasia, Focal           |                   2                                                      |      1  2.0|
      Duct, Cyst, Focal, Multiple          | 1  1     2                    1        2  2     2  1                    1|     13  1.6|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                              3                           |      1  3.0|
      Inflammation, Chronic                |                                     2                 2              3   |      4  2.3|
      Inflammation, Focal                  |                         2                                                |      1  2.0|
      Ulcer                                |                         2                    3        2              3   |      5  2.4|
      Epithelium, Hyperplasia              |       2                 3           2  3     2        2              3   |      8  2.4|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3|            |
                                           | 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Erosion                              |       2                    2                                             |      2  2.0|
      Pigmentation, Focal                  |                            2                                             |      1  2.0|
      Epithelium, Hyperplasia, Focal       |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                        +                                 |   1        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                            +                                             |   1        |
      Peridontal Tissue, Hyperplasia,      |                                                                          |            |
          Squamous                         |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                            2                                             |      3  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                     1                 1        1         |      7  1.0|
      Cytoplasmic Alteration, Focal        |       2                    1     2                                       |      3  1.7|
      Vacuolization Cytoplasmic, Diffuse   |                         3                                                |      1  3.0|
      Vacuolization Cytoplasmic, Focal     | 2  2              1                 1        1  1                        |      8  1.4|
      Capsule, Fibrosis, Focal             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |       2           1  2                 1  1        1     1           2   |     12  1.4|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3|            |
                                           | 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   3      |      4  2.5|
      Hemorrhage                           |                            4                                             |      1  4.0|
      Pars Distalis, Cyst                  |                                                                3         |      1  3.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |       1                 1           1                 2                 2|      7  1.4|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                                                                          |      2  3.0|
      Pars Distalis, Hemorrhage, Focal     |    2                                                                     |      2  2.5|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      2  3.5|
      Rathke's Cleft, Hyperplasia, Cystic  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
      C-Cell, Hyperplasia                  | 2  2  2  1  2  1  2  2  2     2  1  3  1  1  2     2  2  2  2  3  2  2  2|     42  2.0|
      Follicle, Mineralization, Focal      | 2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     2  1  1  1  1  1  1  1|     43  1.1|
      Follicular Cell, Hypertrophy         |                            3              1        1     1  1  1  1      |     13  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                       +                  |   6        |
      Mediastinum, Hemorrhage              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
      Thrombosis                           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3|            |
                                           | 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                      2   |      1  2.0|
      Degeneration, Cystic                 |                                                          3           3   |      2  3.0|
      Hyperplasia, Cystic                  |                                     3                                    |      1  3.0|
      Inflammation, Chronic                | 2        2     1        3                 2              2        1      |     12  1.8|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                | 1  3     1  2     3           2        1     3  2  3        2  3         |     23  2.0|
      Mineralization, Focal                |                                                                          |      2  2.5|
      Epithelium, Hyperplasia, Focal       |                               2                                          |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             3                    3        2        3  3     3            |     10  2.9|
      Bilateral, Atrophy                   |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia, Focal|                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |    2                                                                     |      1  2.0|
      Hyperplasia                          | 2  1     2  3  2  2  3  3  3  2  3  4     3           3  2  1     2     3|     35  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +           +  +  +  +        +  +  +           +           +      |  24        |
      Mediastinal, Ectasia                 |    3              3                                   3           3      |      7  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      2  2.5|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      3  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  3.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                         3                                                |      1  3.0|
      Pancreatic, Ectasia                  |                                     3     3                              |      3  3.0|
      Pancreatic, Hemorrhage               |       3                 3                                                |      3  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3|            |
                                           | 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pancreatic, Hyperplasia, Histiocytic |                            3        3     3                              |      5  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                            3                                             |      1  3.0|
      Pancreatic, Pigmentation             |                                                                          |      1  2.0|
      Renal, Hyperplasia, Focal,           |                                                                          |            |
          Histiocytic                      |                      3                                                   |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   2        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  3.0|
      Hemorrhage                           |       3                                                                  |      2  2.5|
      Hyperplasia, Histiocytic             |             3              3                                             |      3  3.0|
      Hyperplasia, Lymphoid                |                            3                                             |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Angiectasis, Focal                   |                                                                          |      2  3.0|
      Fibrosis, Focal                      |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |             2        2     2                                             |      6  2.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                                           2                              |      1  2.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|  48        |
      Cyst                                 |       2                                                                  |      1  2.0|
      Hemorrhage                           |                            2                                             |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  M  +  M  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +|  43        |
      Dilatation                           |          2        3                          3              2            |      7  2.7|
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3|            |
                                           | 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                      3                                                   |      2  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      1  3.0|
      Artery, Subcutaneous Tissue,         |                                                                          |            |
          Thrombosis                       |                      3                                                   |      1  3.0|
      Lip, Inflammation, Chronic, Focal    |                                                                          |      1  3.0|
      Subcutaneous Tissue, Cyst            |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic, Focal                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |    3                                         3                           |      6  2.8|
      Hemorrhage, Focal                    |                                                 3                        |      2  3.5|
      Cerebrum, Ventricle, Hydrocephalus   |                                  2                                       |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |                                                                   2      |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3|            |
                                           | 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Hyperplasia, Histiocytic             |                                                                          |      1  1.0|
      Infiltration Cellular, Mixed Cell    | 2  2                                                                     |      3  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      2  1.0|
      Inflammation, Focal, Suppurative     |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                           1           1           3      |      5  1.6|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
      Interstitium, Edema                  |                                                                          |      1  3.0|
      Mediastinum, Edema                   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Peritracheal Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Cataract                             |                                                                          |      2  2.5|
      Exudate                              |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3|            |
                                           | 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    125 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst, Multiple                       |                                                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  4.0|
      Infarct, Multiple                    |                                                                      3   |      1  3.0|
      Metaplasia, Focal, Lipocyte          |                                                                          |      1  3.0|
      Nephropathy                          | 2  2  1  1  1  1  2  1  2  2  3  1  3  2  1  3  1  2  2  2  2  2  2  2  2|     44  1.7|
      Cortex, Medulla, Atrophy             |                                                                          |      1  4.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                      2   |      1  2.0|
      Renal Tubule, Hyperplasia, Focal     |                                           2                              |      1  2.0|
      Renal Tubule, Pigmentation           |       2                 2                                                |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Calculus Micro Observation Only      |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|             
                                           | 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  A  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A|             
      Epithelium, Necrosis                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Angiectasis, Focal                   |                                              2                           |             
      Basophilic Focus                     |    X        X           X  X  X     X  X     X     X     X  X     X  X   |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |    X        X           X  X  X     X  X        X  X     X  X     X  X   |             
      Degeneration, Cystic, Focal          |                      2  2  2        1        2                 4         |             
      Hepatodiaphragmatic Nodule           |                                     3                                    |             
      Hyperplasia, Focal, Histiocytic      |    1                                   1        1                        |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Infiltration Cellular, Mixed Cell    |    2  2  2  2  2        2  2  2  2  1  2        2  2  1  2  2        2   |             
      Mixed Cell Focus                     |                                              X                       X   |             
      Bile Duct, Hyperplasia               | 3  3  3  3  3     3  3  2  3  3  2  2  3  3  3  3  3  1  3  2  4  2  1   |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |             2           2  2                                      2      |             
      Hepatocyte, Periportal,              |                                                                          |             
          Vacuolization Cytoplasmic        |    2                                                                     |             
      Hepatocyte, Centrilobular, Necrosis  | 3                 2                       3                              |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        | 3     3  3        3  3                    4                              |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +     +              +     +  +        +                 +     +  +  +|             
      Hemorrhage                           |                                  3                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|             
                                           | 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Inflammation, Chronic                |                                  3                                       |             
      Fat, Necrosis, Focal                 |    1     3              2     3                             2     3  3  3|             
      Fat, Necrosis                        |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 2  2  3  3     2     1  3     2     1  1  3  1  1     3        2     3  2|             
      Duct, Cyst, Focal                    |                            3                                             |             
      Duct, Cyst, Focal, Multiple          |    2  2  3  2                 1     2           2     1           2      |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Focal                  |          3                                                               |             
      Ulcer                                |                   2  1                                                   |             
      Epithelium, Hyperplasia, Focal       |          3                                                               |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Erosion                              | 2                 1  2                                                   |             
      Pigmentation, Focal                  |                   1                                                      |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Malformation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                +                 +                                       |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                              2                           |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|             
                                           | 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    1     2  1                                                            |             
      Atrophy                              |                                                                3         |             
      Cytoplasmic Alteration, Focal        |             2                                                            |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Hyperplasia, Diffuse                 |                                                                3         |             
      Necrosis, Focal                      |                                  2                                       |             
      Vacuolization Cytoplasmic, Focal     |                                                       2  3     3         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2                 1        2                                   1         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |             1                                                            |             
      Pars Distalis, Hemorrhage, Focal     |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Pars Nervosa,         |                                                                          |             
          Hemorrhage, Focal                |                                                                          |             
      Pars Intermedia, Hemorrhage, Focal   |                                                                          |             
      Rathke's Cleft, Hemorrhage           |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia                  | 2  3  3  2  2           2  2  3        2  2  1  2  3     3  1  3  2  1   |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Mineralization, Focal      | 3  1  3  2  1  1        3  1  2     3  2  1  2  2  1     1  1  1  3  2   |             
      Follicular Cell, Hypertrophy         |    1  1  2  2  2        1  2  1        1  1  2           1  2  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|             
                                           | 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              | +                                                        +               |             
      Abdominal, Fibrosis                  |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               2                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Inflammation, Chronic                |    2              2           2     2     1  1  2                 2      |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       3  2           4  3     2  4  1  3  1     2     3  4     2         |             
      Mineralization, Focal                |                                                             2            |             
      Epithelium, Hyperplasia, Focal       |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2  3           3                    3     3        3               |             
      Interstitial Cell, Hyperplasia, Focal|                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3        3  3     4  3  2  2  2  3  2     3     2  3  2  3     3  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +     +     +  +  +  +  +  +     +  +  +  +  +              +     +  +|             
      Deep Cervical, Hemorrhage            |                3                                                         |             
      Mediastinal, Angiectasis             |                                                                         3|             
      Mediastinal, Ectasia                 |    4                          3                 2                        |             
      Mediastinal, Hemorrhage              |          3                                                               |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                         3|             
      Mediastinal, Hyperplasia, Lymphoid   |                         3                                                |             
      Mediastinal, Hyperplasia, Plasma Cell|                                     3  3                                 |             
      Pancreatic, Ectasia                  |                            3                                   3         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|             
                                           | 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pancreatic, Hemorrhage               |                   2                                                      |             
      Pancreatic, Hyperplasia, Histiocytic |    3                    3           3                                3   |             
      Pancreatic, Pigmentation             |                   3                                                      |             
      Renal, Hemorrhage                    |                3                                                         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                 3                        |             
      Hemorrhage                           |    3  3                                                  3               |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Angiectasis, Focal                   |                                              3                           |             
      Fibrosis, Focal                      |       3                                      3                           |             
      Hematopoietic Cell Proliferation     |    2     2     3                                      3                  |             
      Hyperplasia, Focal, Histiocytic      |                                                                      1   |             
      Metaplasia, Focal, Lipocyte          |                                                                          |             
      Pigmentation, Focal                  |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3                  |             
      Hemorrhage                           |             2  2                 3                                       |             
      Hyperplasia, Lymphoid                |             3  2                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2     3                                2                    2            |             
      Hyperplasia                          |                      3           2                                       |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                    2                     |             
      Hyperkeratosis, Focal                | 3                                                                        |             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        |                                                    3                     |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic, Focal, Suppurative     |                                                    3                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|             
                                           | 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |       3  3                       3              3                       3|             
      Hemorrhage, Focal                    |                      1                    2                              |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |          +                                +     +                        |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |          +                                +     +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  3                    3                 3|             
      Hemorrhage, Focal                    |                         2                                                |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                         2|             
      Inflammation, Chronic, Focal         |             2                 1                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    2                     |             
      Alveolus, Edema, Focal               |                                                       2                  |             
      Mediastinum, Edema                   |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Foreign Body                         |                                              2                           |             
      Inflammation, Suppurative            |                         2           3        2           1               |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Focal                           |                                     2                                    |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Focal                           |                                     3                                    |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|             
                                           | 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1000MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Cataract                             |                                                       3                  |             
      Cornea, Inflammation, Chronic        |                                                          3               |             
      Retina, Degeneration                 |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                           +                              |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Nephropathy                          | 1  1  3  1  2  1  1  2  2  2  1  1  3  2  2  1  3  1  3  2  2  2  2  1  2|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                  2                                       |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          | 2                 3                       1                              |             
      Renal Tubule, Pigmentation           |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hemorrhage                           |       2                          2                                       |             
      Inflammation, Chronic                |                                  4                                       |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  42        |
      Epithelium, Necrosis                 |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Basophilic Focus                     | X  X  X  X     X  X  X     X  X  X  X  X  X  X  X  X        X  X     X  X|     33     |
      Cholangiofibrosis                    |                               4                                          |      1  4.0|
      Clear Cell Focus                     | X  X           X     X     X     X  X  X  X  X  X  X        X  X     X  X|     29     |
      Degeneration, Cystic, Focal          | 2           2        2  2                                      1        2|     12  2.0|
      Hepatodiaphragmatic Nodule           |                               3                             3            |      3  3.0|
      Hyperplasia, Focal, Histiocytic      |       1        2        2  1  3                                          |      8  1.5|
      Hyperplasia, Focal, Lymphoid         |                               3                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    | 2  1     2     1     2  3  2  2     2  2  1  2  2  2        2        2   |     33  1.9|
      Mixed Cell Focus                     |          X                                                               |      3     |
      Bile Duct, Hyperplasia               | 3  3  3  3  3     3  3  3  3  3  3  3  3  3  3  3  3  3     3  3  3  3  3|     46  2.8|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |    2     2     2           2  1     2  3  2  1                       2   |     14  1.9|
      Hepatocyte, Periportal,              |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                          |      1  2.0|
      Hepatocyte, Centrilobular, Necrosis  |             2                                         3           2      |      6  2.5|
      Hepatocyte, Centrilobular,           |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
          Vacuolization Cytoplasmic        |       2     3     3              2                    3           3      |     12  2.9|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +              +  +     +                 +              +        +  +   |  19        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 | 3              3  2                       3                          2   |     13  2.5|
      Fat, Necrosis                        |                                                          3               |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |       1  1  1  2     2     3        2        1     1           2         |     27  1.9|
      Duct, Cyst, Focal                    |                                                                          |      1  3.0|
      Duct, Cyst, Focal, Multiple          |       1  2        2                 2  1     2  2  2                 2   |     18  1.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                         3                                                |      1  3.0|
      Inflammation, Chronic, Focal         |                         3                                                |      1  3.0|
      Inflammation, Focal                  |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      2  1.5|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Erosion                              |             2                                                            |      4  1.8|
      Pigmentation, Focal                  |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                          +               |   1        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                             +            |   1        |
      Malformation                         |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
   Blood Vessel                            |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1     2                                1              2     2         |      7  1.7|
      Thrombosis                           |             3     3                                                      |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                        1                                 |      4  1.3|
      Atrophy                              |                                                                          |      1  3.0|
      Cytoplasmic Alteration, Focal        |                      1                                                   |      2  1.5|
      Degeneration, Cystic, Focal          |                                  4                             2         |      2  3.0|
      Hyperplasia, Diffuse                 |                                                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                        1              1        1        2|      7  1.9|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |          2  1     2     1                                   2            |      9  1.6|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                     2                                    |      1  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                            1                                1            |      3  1.0|
      Pars Distalis, Hemorrhage, Focal     |                                                             2            |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                   1                 4        2                           |      3  2.3|
      Pars Distalis, Pars Nervosa,         |                                                                          |            |
          Hemorrhage, Focal                |                                  3                                       |      1  3.0|
      Pars Intermedia, Hemorrhage, Focal   |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Rathke's Cleft, Hemorrhage           |                                                       2                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  43        |
      C-Cell, Hyperplasia, Focal           |                         2                                                |      1  2.0|
      C-Cell, Hyperplasia                  | 3  1  2  2  2  2  2  1  2  1  1  2  3  3  1  2  2  1  2     3  2     3  2|     41  2.0|
      Follicle, Cyst                       |                                                                         2|      1  2.0|
      Follicle, Mineralization, Focal      | 3  3  3  1  1  1  3  1     2  1  3  3  3  1  3  3  3  3     2  1     1  1|     42  2.0|
      Follicular Cell, Hypertrophy         | 1  2  2        1  1     1  2  2  2  2  1  1     2  2        1  2     2   |     33  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Abdominal, Fibrosis                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                  3                                       |      1  3.0|
      Inflammation, Chronic                |    1           2  2  2  2  1           2  1        3  2                  |     18  1.8|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    1     2  2     2  1  2     2     2  1     1     2  2     2     2  2  3|     29  2.2|
      Mineralization, Focal                |       2                    2                                             |      3  2.0|
      Epithelium, Hyperplasia, Focal       |       2                                                                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          3                 3                                3            |      9  2.9|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Interstitial Cell, Hyperplasia, Focal|                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  2  3  3  2  3  3  3  2  1  1  2  1  2  1  2  2     2  2  3     3  2|     41  2.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +           +     +     +        +  +     +     +     +                  |  26        |
      Deep Cervical, Hemorrhage            |                                                                          |      1  3.0|
      Mediastinal, Angiectasis             |                                                                          |      1  3.0|
      Mediastinal, Ectasia                 |                         3                       3                        |      5  3.0|
      Mediastinal, Hemorrhage              |                                     3                                    |      2  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                     3                                    |      2  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      2  3.0|
      Pancreatic, Ectasia                  |             3                                                            |      3  3.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Histiocytic | 3           3                       3     3     3                        |      9  3.0|
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
      Renal, Hemorrhage                    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.5|
      Hyperplasia, Focal, Histiocytic      |    3                                                                     |      2  2.0|
      Metaplasia, Focal, Lipocyte          |                                                             2            |      1  2.0|
      Pigmentation, Focal                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      3  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Dilatation                           |             2     2                                                     2|      7  2.1|
      Hyperplasia                          |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                             3  2         |      3  2.3|
      Hyperkeratosis, Focal                |                                                                          |      1  3.0|
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |            |
          Inclusion                        |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic, Focal, Suppurative     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                                  3                                      3|      7  3.0|
      Hemorrhage, Focal                    |                                                       1           1      |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                         +                                                |   4        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Spinal Cord                             |                         +                    +                           |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      3  3.0|
      Hemorrhage, Focal                    |       2                                                                  |      2  2.0|
      Hemorrhage                           |                                                          2               |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                                                                      1   |      1  1.0|
      Hyperplasia, Histiocytic             |                                                          1               |      1  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                         1                                                |      3  1.3|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                      2                                         2         |      3  2.0|
      Alveolus, Edema, Focal               |                                                                          |      1  2.0|
      Mediastinum, Edema                   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                    2                     |      2  2.0|
      Inflammation, Suppurative            |                         2                          2                     |      6  2.0|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +|  46        |
      Cataract                             |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1000MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hyperplasia, Focal, Histiocytic      |                                        2                                 |      1  2.0|
      Inflammation, Chronic, Focal         |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Cyst                                 |       2                                                                  |      1  2.0|
      Infarct                              |                                                       3                  |      1  3.0|
      Nephropathy                          | 2  2  2  2  2  2  2  1  2  1  1  2  2  1  1  2  1  1  3     2  2     2  2|     48  1.8|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                         3                                                |      4  2.3|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|  47        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|             
                                           | 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3                                3                              |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                           3                              |             
      Hemorrhage                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +|             
      Edema                                |                                           3                              |             
      Ulcer                                |                         4                                                |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Epithelium, Hyperplasia              |                                           3                              |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                         2|             
      Basophilic Focus                     |                X           X  X  X  X     X  X     X     X     X        X|             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |                X           X     X  X              X     X              X|             
      Degeneration, Cystic, Focal          |                2  2        2        2                                   2|             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hepatodiaphragmatic Nodule           | 3              X                                                         |             
      Hyperplasia, Focal, Histiocytic      |                2                                      2                  |             
      Hyperplasia, Focal, Lymphoid         |                                                       2                  |             
      Infiltration Cellular, Mixed Cell    | 2     2        2        2  2  2  3  2        2     2  2        2        2|             
      Mixed Cell Focus                     |       X                          X                             X         |             
      Bile Duct, Hyperplasia               | 3  3  3  4  2  3  3  3  2  3  3  3  3  3  2  2  3  3  2  3  3  3  3  4  3|             
      Hepatocyte, Necrosis, Focal          |          3                                                               |             
      Hepatocyte, Vacuolization            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|             
                                           | 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
          Cytoplasmic, Diffuse             |                3                          4                              |             
      Hepatocyte, Vacuolization            |                                                                          |             
          Cytoplasmic, Focal               |          3                                   1     1     1     1         |             
      Hepatocyte, Centrilobular, Atrophy   |                                        3                                 |             
      Hepatocyte, Centrilobular, Necrosis  |                      2                          3                    3   |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Vacuolization Cytoplasmic        |    3                 2  3              3        3                 3  3   |             
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |             
          Cytoplasmic                      |                                                             3            |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +     +  +     +  +     +     +        +     +     +        +  +  +   |             
      Inflammation, Chronic, Focal         |                                           3                              |             
      Fat, Necrosis, Focal                 |    3     1  4        2     3     2                             1     2   |             
      Fat, Necrosis                        |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               | 1                          3  1              1  2  1           2     3  1|             
      Duct, Cyst, Focal                    |                                           3                              |             
      Duct, Cyst, Focal, Multiple          |                2        2  2           2                    2            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           3                              |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3                                                  3            |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |          2                                                  3            |             
      Epithelium, Hyperplasia              |          2                                2                 2            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |    1                                                        2        1   |             
      Perforation                          |                                           3                              |             
      Ulcer                                |    2                    2                 4                              |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|             
                                           | 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2        2           2           2              2                  |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic, Focal         |                         3                                                |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                           1                              |             
      Cytoplasmic Alteration, Focal        |                                                       2                  |             
      Infiltration Cellular, Mixed Cell    |                               2                                          |             
      Vacuolization Cytoplasmic, Focal     |    2                          2           1                              |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          2           3  2  2                    1     2           2      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2     3                                                   |             
      Hemorrhage, Focal                    |                                                       2                  |             
      Pars Distalis, Cyst                  |                                                                2         |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |       1        2                                            1  1         |             
      Pars Distalis, Hemorrhage, Focal     |       3                                               2                  |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Rathke's Cleft, Cyst                 |                                                                          |             
      Rathke's Cleft, Hemorrhage           |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +|             
      C-Cell, Hyperplasia                  | 1  1  2     3  2     2  3  2  2  3  2  1  1  2     2  2  1  2  2  2     2|             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Mineralization, Focal      | 3  1  3     1  1     1     3  1  3  2  2  1  3     3     3  1  3  3     2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|             
                                           | 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Follicular Cell, Hypertrophy         | 3     2  1  1  1           2  2  2  2     3  2     3  2  1  1  2  1     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |          +                             +        +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                           3                              |             
      Inflammation, Chronic                |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      3   |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Cystic                  |                                     3                                    |             
      Inflammation, Chronic                |                                        2     1  1        2     1         |             
      Necrosis                             |                         3                                                |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2     2           2        1     3  2        2  3     2  1  1  2  2     1|             
      Mineralization, Focal                |          3                 2                                             |             
      Epithelium, Hyperplasia, Focal       |       2     1                       1                    1               |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                       3     3        3  4                              |             
      Germinal Epithelium, Atrophy         |                                                       3                  |             
      Interstitial Cell, Hyperplasia, Focal| 2                 2                                               1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3                        |             
      Hyperplasia                          | 2  4  3     3  2     4  3  2  3  3  3        2  3  2  3  3  4  2  4     2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +  +           +  +  +  +           +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|             
                                           | 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hemorrhage                           |                                           3                              |             
      Mediastinal, Ectasia                 |                                           3                              |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                            3                                             |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                         3|             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                         3                                                |             
      Pancreatic, Ectasia                  | 3                       3                    3                           |             
      Pancreatic, Hemorrhage               |       3                                                                  |             
      Pancreatic, Hyperplasia, Histiocytic |                         3  3                                   3         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  +  M  +  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    4                                                                     |             
      Ectasia                              |    4                                         4                           |             
      Hyperplasia, Histiocytic             |                         3                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                      2                                      2            |             
      Atrophy                              |                                           2                              |             
      Congestion                           |                            3                                             |             
      Fibrosis, Focal                      |       4              2                                      2            |             
      Hematopoietic Cell Proliferation     | 2                       3     3                       3                  |             
      Hyperplasia, Focal, Histiocytic      |                3                                                         |             
      Infarct, Multiple                    |                                                                      3   |             
      Pigmentation                         |                                           3                              |             
      Capsule, Fibrosis, Focal             |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Dilatation                           |                                                                   3      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|             
                                           | 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic, Focal         |                            1                                             |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |    2                                                                     |             
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |             
           Focal, Histiocytic              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   | 3                                         3                       3      |             
      Hemorrhage, Focal                    |             3                                               2        3   |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                   +                                                      |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |             2                                                            |             
      Hyperplasia, Histiocytic             |                                                 1                        |             
      Infiltration Cellular, Mixed Cell    |                      3                                                  2|             
      Inflammation, Chronic, Focal         |                      3                                         1         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                      3                                                   |             
      Interstitium, Edema                  |          3                                                               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                         2|             
      Inflammation, Suppurative            |                                                                         2|             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|             
                                           | 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2000MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3                                   3|             
      Cataract                             |                                                                          |             
      Cornea, Retrobulbar, Inflammation,   |                                                                          |             
           Chronic Active                  |                         3                                                |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                 2                        |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic Active, Diffuse|                         4                                                |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                     +                                    |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |          +        +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  2  3  1  2     2  2  1  1  2  2  2  4  3  1  2  1  1  1  2  3     2|             
      Pelvis, Infiltration Cellular, Mixed |                                                                          |             
          Cell                             |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                         3                             2                  |             
      Renal Tubule, Pigmentation           |          4           3                          2     2                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3                                      3                        |             
      Serosa, Inflammation, Focal          |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3|            |
                                           | 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                      3   |      1  3.0|
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                      3   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Edema                                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                2           2                                             |      3  2.0|
      Basophilic Focus                     | X  X     X  X     X  X        X     X  X  X     X  X  X  X  X  X     X  X|     29     |
      Cholangiofibrosis                    |                                        2                                 |      1  2.0|
      Clear Cell Focus                     |    X        X     X  X              X     X           X  X               |     15     |
      Degeneration, Cystic, Focal          |          2  1  2           2                       2  2        1     2  2|     14  1.9|
      Eosinophilic Focus                   |          X                                            X                  |      2     |
      Fibrosis, Focal                      |                                        2                                 |      1  2.0|
      Hepatodiaphragmatic Nodule           |                3           3                       3                     |      5  3.0|
      Hyperplasia, Focal, Histiocytic      |                   1                 1     1                              |      5  1.4|
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    | 2  2     2  2     2  2     2        2     2  2  1  2  2  2           2   |     28  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3|            |
                                           | 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mixed Cell Focus                     |                X     X                 X           X        X            |      8     |
      Bile Duct, Hyperplasia               | 2  3  3  3  3  3  3  3  2  3  1  3  3  3  3  3  3  3  3  3  3  3  3  3  3|     50  2.9|
      Hepatocyte, Necrosis, Focal          |                                  2                                       |      2  2.5|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             | 3                          3                                             |      4  3.3|
      Hepatocyte, Vacuolization            |                                                                          |            |
          Cytoplasmic, Focal               |    2     1  2  2  2  1              2  2     1  1  3  2        2         |     18  1.7|
      Hepatocyte, Centrilobular, Atrophy   |                                                                          |      1  3.0|
      Hepatocyte, Centrilobular, Necrosis  |                                                                      2   |      4  2.5|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Vacuolization Cytoplasmic        |       3                                                  2  2     2      |     11  2.6|
      Hepatocyte, Midzonal, Vacuolization  |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +        +     +  +     +  +           +     +        +     +      |  23        |
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                3     3        1              4     3        3            |     14  2.5|
      Fat, Necrosis                        |                         2                                                |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Diffuse             |                                                          4               |      1  4.0|
      Acinus, Atrophy, Focal               |                                     1  2  2        2        1        2   |     15  1.7|
      Duct, Cyst, Focal                    |                                                                          |      1  3.0|
      Duct, Cyst, Focal, Multiple          |          2  1     2        3           1     2        1  2  2        1   |     15  1.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |                                                                3         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                | 3                                                                    3   |      4  3.0|
      Inflammation, Chronic                | 3                                                                        |      1  3.0|
      Ulcer                                |                            3                                         3   |      4  2.8|
      Epithelium, Hyperplasia              | 3                       2  3                                         2   |      7  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3|            |
                                           | 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                         2                                                |      4  1.5|
      Perforation                          |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                1  2                             1  2                    2|     10  1.8|
      Infiltration Cellular, Mixed Cell    |             2        2                                                   |      2  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Thrombosis                           |       3                                                                 3|      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                      1                                                  1|      3  1.0|
      Cytoplasmic Alteration, Focal        | 2              2                                               1         |      4  1.8|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     | 1  1                                                                    2|      6  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |       2                                      1                 1  2  1  2|     13  1.8|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             3                                                            |      3  2.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3|            |
                                           | 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                     1     2        1        2            |      8  1.4|
      Pars Distalis, Hemorrhage, Focal     |                               3                                          |      3  2.7|
      Pars Distalis, Hyperplasia, Focal    |                                     2                                    |      1  2.0|
      Rathke's Cleft, Cyst                 |                                  4                                       |      1  4.0|
      Rathke's Cleft, Hemorrhage           |                               3                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      C-Cell, Hyperplasia                  | 3  2  2  2  3  1  2  2  2  1  2  2  1  1  3     1  1  2  1  2  2  2  1   |     44  1.8|
      Follicle, Cyst                       |                                        3  3                              |      2  3.0|
      Follicle, Mineralization, Focal      | 2     3  3  3  3  3  3  1  1  1     3  3  3  3  1  3  3  3  3  3  2  2  2|     42  2.3|
      Follicular Cell, Hypertrophy         | 3  2     2  2  2  3  3     2  1  1  1  3  2  3  3  2  2  3  2  2  2     1|     40  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                                +      |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                          2               |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Degeneration, Cystic                 |                3                                   3                     |      2  3.0|
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
      Inflammation, Chronic                | 1  1     1  1     1  2        1  1  2  1  2  1     1        1  2         |     20  1.3|
      Necrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 3  1     2        1  1  2     1  1  2  2  2        1  3  1  2     2      |     30  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3|            |
                                           | 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Mineralization, Focal                |             2     2                                                      |      4  2.3|
      Epithelium, Hyperplasia, Focal       |    1     1  1  1     1                 2                                1|     11  1.2|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                         3|      6  3.2|
      Germinal Epithelium, Atrophy         |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia, Focal|                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          | 2  2     2  1  3  2  3     4  4     2  3  3  3  2  2  2  2  2  3     2   |     40  2.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +        +  +  +  +  +  +  +        +  +     +     +  +     +  +  +|  34        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Mediastinal, Ectasia                 |                   4        3                                             |      3  3.3|
      Mediastinal, Hemorrhage              |                                                                      3   |      1  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                      4                       3                           |      3  3.3|
      Mediastinal, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Pancreatic, Ectasia                  |                               3                             2        3   |      6  2.8|
      Pancreatic, Hemorrhage               |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Histiocytic |                                           3        3     3               |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M|   4        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Ectasia                              |                                           3                              |      3  3.7|
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3|            |
                                           | 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Lymphoid                |                            3                                             |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |       3                                                                  |      3  2.3|
      Atrophy                              |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis, Focal                      |       3                                                                  |      4  2.8|
      Hematopoietic Cell Proliferation     | 2                    2     3  2                                2     3  2|     11  2.5|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  3.0|
      Infarct, Multiple                    |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Capsule, Fibrosis, Focal             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  44        |
      Cyst                                 |                                              3                           |      1  3.0|
      Dilatation                           |                                                       2                  |      2  2.5|
      Hyperplasia                          |       3  3                                                               |      2  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1  2.0|
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |            |
           Focal, Histiocytic              |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3|            |
                                           | 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   | 4                    2                                3                  |      6  3.0|
      Hemorrhage, Focal                    |                         3  3                                      2      |      6  2.7|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |       +                    +                                             |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |       +                    +              +  +                           |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                   2                                                      |      2  2.0|
      Hyperplasia, Histiocytic             |                                                 1                        |      2  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  2.5|
      Inflammation, Chronic, Focal         |       1                                                                  |      3  1.7|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                   2                                4                 2   |      4  2.8|
      Interstitium, Edema                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      2  3.0|
      Cataract                             |       2  3                                                               |      2  2.5|
      Cornea, Retrobulbar, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 121                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 05/27/03    
Route: DOSED WATER                                                                                                Time: 13:28:43    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3|            |
                                           | 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2000MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Retina, Degeneration                 |       3  3                                                               |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                                           1                              |      1  1.0|
      Inflammation, Chronic, Focal         |    2                                                                     |      1  2.0|
      Inflammation, Chronic Active, Diffuse|                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                            +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nephropathy                          | 2  2  2  1  1  2  2  1  2  2  2     1  2  2  1  1  2  2  1  2  2  1  2  1|     47  1.7|
      Pelvis, Infiltration Cellular, Mixed |                                                                          |            |
          Cell                             |                         2                                                |      1  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      2  2.5|
      Renal Tubule, Pigmentation           |                                                                          |      4  2.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      2  3.0|
      Serosa, Inflammation, Focal          |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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